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Last Updated :2023/11/30
Takumi Koshiba
Faculty of Science
Professor
Researcher information
■ Degree
■ Research Keyword
■ Field Of Study
■ Research Keyword
■ Field Of Study
Career
■ Career
- Apr. 2019 - Present
Fukuoka University, Faculty of Science, Professor - Apr. 2007 - Mar. 2019
Kyushu University, 大学院理学研究院 生物科学部門, Associate Professor - Apr. 2005 - Mar. 2007
Kyushu University, 大学院理学研究院 生物科学部門, Assistant Professor - Apr. 2001 - Mar. 2005
California Institute of Technology, Division of Biology, Postdoctoral Fellow - Jan. 2000 - Mar. 2002
日本学術振興会特別研究員
- Apr. 2001 - Mar. 2005
California Institute of Technology, Biology, Postdoctoral Scholar - Apr. 1996 - Mar. 2001
北海道大学大学院, 理学研究科, 生物科学専攻 - Apr. 1992 - Mar. 1996
Hokkaido University, School of Fisheries Sciences, 水産化学科
- 2024 - Present
代議員, 日本生化学会 - 2022 - Present
Frontiers in Immunology - 2022 - Present
評議員, 日本ミトコンドリア学会 - 2022 - Present
評議員, 日本生化学会 - 2021 - Present
Editorial Board, Mitochondrial Communications - 2018 - Present
Advisory Board members, The Journal of Biochemistry - 2017 - Present
分野別専門委員, 日本生物物理学会 - 2013
役員等選挙実施委員, 日本生化学会
Research activity information
■ Award
■ Paper
■ Affiliated academic society
■ Media Coverage
■ Paper
- Mitochondrial reactive zones in antiviral innate immunity
Yasukawa, K.; Koshiba, T.
Biochimica et Biophysica Acta (BBA) - General Subjects, 2021, Refereed, Invited, Last - Mass spectrometry-based methods for analyzing the mitochondrial interactome in mammalian cells
Koshiba, T.; Kosako, H.
J. Biochem., 2020, Refereed, Invited, Lead - MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity
Hanada, Y.; Ishihara, N.; Wang, L.; Otera, H.; Ishihara, T.; Koshiba, T.; Mihara, K.; Ogawa, Y.; Nomura, M.
Nature Communications, 2020, Refereed, Not invited - Mitochondria – in the crossfire of SARS-CoV-2 and immunity
Burtscher, J.; Cappellano, G.; Omori, A.; Koshiba, T.; Millet, G.P.
iScience, 2020, Refereed, Not invited - Influenza Virus-Induced Oxidized DNA Activates Inflammasomes.
Moriyama, M.; Nagai, M.; Maruzuru, Y.; Koshiba, T.; Kawaguchi, Y.; Ichinohe, T.
iScience, 2020, Refereed, Not invited - The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity
Yasukawa, K; Kinoshita, D; Yaku, K; Nakagawa, T; Koshiba, T
J. Biol. Chem., 2020, Refereed, Not invited, Last - Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
Moriyama, M; Koshiba, T; Ichinohe, T
Nat. Commun., 2019, Refereed, Not invited - Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region.
Yoshinaka T; Kosako H; Yoshizumi T; Furukawa R; Hirano Y; Kuge O; Tamada T; Koshiba T
iScience, 2019, Refereed, Not invited, Last - Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity.
Moriyama M; Igarashi M; Koshiba T; Irie T; Takada A; Ichinohe T
J Virol., Sep. 2018, Refereed, Not invited - Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication
Yuhei Maruzuru; Takeshi Ichinohe; Ryota Sato; Kensuke Miyake; Tokuju Okano; Toshihiko Suzuki; Takumi Koshiba; Naoto Koyanagi; Shumpei Tsuda; Mizuki Watanabe; Jun Arii; Akihisa Kato; Yasushi Kawaguchi
Cell Host and Microbe, 14 Feb. 2018, Refereed, Not invited - RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity
Takuma Yoshizumi; Hiromi Imamura; Tomohiro Taku; Takahiro Kuroki; Atsushi Kawaguchi; Kaori Ishikawa; Kazuto Nakada; Takumi Koshiba
SCIENTIFIC REPORTS, Jul. 2017, Refereed, Not invited, Last - The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1 beta Secretion
Miyu Moriyama; I-Yin Chen; Atsushi Kawaguchi; Takumi Koshiba; Kyosuke Nagata; Haruko Takeyama; Hideki Hasegawa; Takeshi Ichinohe
JOURNAL OF VIROLOGY, Apr. 2016, Refereed, Not invited - Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease
Tammy T. Nguyen; Sang S. Oh; David Weaver; Agnieszka Lewandowska; Dane Maxfield; Max-Hinderk Schuler; Nathan K. Smith; Jane Macfarlane; Gerald Saunders; Cheryl A. Palmer; Valentina Debattisti; Takumi Koshiba; Stefan Pulst; Eva L. Feldman; Gyoergy Hajnoczky; Janet M. Shaw
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2014, Refereed, Not invited - Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity
Takuma Yoshizumi; Takeshi Ichinohe; Osamu Sasaki; Hidenori Otera; Shun-ichiro Kawabata; Katsuyoshi Mihara; Takumi Koshiba
NATURE COMMUNICATIONS, Aug. 2014, Refereed, Not invited, Last - Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection
Takeshi Ichinohe; Tatsuya Yamazaki; Takumi Koshiba; Yusuke Yanagi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2013, Refereed, Not invited - A structural perspective of the MAVS-regulatory mechanism on the mitochondrial outer membrane using bioluminescence resonance energy transfer
Osamu Sasaki; Takuma Yoshizumi; Misa Kuboyama; Takeshi Ishihara; Emiko Suzuki; Shun-ichiro Kawabata; Takumi Koshiba
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, May 2013, Refereed, Not invited, Last - Mitochondrial-mediated antiviral immunity
Takumi Koshiba
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Jan. 2013, Refereed, Invited, Lead - Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology
Kenta Onoue; Akihiro Jofuku; Reiko Ban-Ishihara; Takaya Ishihara; Maki Maeda; Takumi Koshiba; Takashi Itoh; Mitsunori Fukuda; Hidenori Otera; Toshihiko Oka; Hiroyoshi Takano; Noboru Mizushima; Katsuyoshi Mihara; Naotada Ishihara
Journal of Cell Science, 01 Jan. 2013, Refereed, Not invited - Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling
Takumi Koshiba; Kai Yasukawa; Yusuke Yanagi; Shun-ichiro Kawabata
SCIENCE SIGNALING, Feb. 2011, Refereed, Not invited, Lead - Structure-Function Analysis of the Yeast Mitochondrial Rho GTPase, Gem1p
Takumi Koshiba; Holly A. Holman; Kenji Kubara; Kai Yasukawa; Shun-ichiro Kawabata; Koji Okamoto; Jane Macfarlane; Janet M. Shaw
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2011, Refereed, Not invited, Lead - Regulation of antiviral immunity on the mitochondrial outer membrane
Takumi Koshiba
Seikagaku, 2010, Refereed, Not invited - Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling
Kai Yasukawa; Hiroyuki Oshiumi; Makoto Takeda; Naotada Ishihara; Yusuke Yanagi; Tsukasa Seya; Shun-ichiro Kawabata; Takumi Koshiba
SCIENCE SIGNALING, Aug. 2009, Refereed, Not invited, Last - A structural perspective on the interaction between lipopolysaccharide and Factor C, a receptor involved in recognition of Gram-negative bacteria
Takumi Koshiba; Tornoyuki Hashii; Shun-ichiro Kawabata
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2007, Refereed, Not invited, Lead - Crystallization of a 2 : 2 complex of granulocyte-colony stimulating factor (GCSF) with the ligand-binding region of the GCSF receptor
E Honjo; T Tamada; Y Maeda; T Koshiba; Y Matsukura; T Okamoto; M Ishibashi; M Tokunaga; R Kuroki
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Aug. 2005, Refereed, Not invited - Structural basis of mitochondrial tethering by mitofusin complexes
T Koshiba; SA Detmer; JT Kaiser; HC Chen; JM McCaffery; DC Chan
SCIENCE, Aug. 2004, Refereed, Not invited, Lead - Thermodynamic analysis of the activation mechanism of the GCSF receptor induced by ligand binding
S Mine; T Koshiba; E Honjo; T Okamoto; T Tamada; Y Maeda; Y Matsukura; A Horie; M Ishibashi; M Sato; M Azuma; M Tokunaga; K Nitta; R Kuroki
BIOCHEMISTRY, Mar. 2004, Refereed, Not invited - The prefusogenic intermediate of HIV-1 gp41 contains exposed C-peptide regions
T Koshiba; DC Chan
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2003, Refereed, Not invited, Lead
- 炎症制御におけるミトコンドリアの新規機能の解明
実験医学, 2023, Not refereed, Invited
Last - 自然免疫応答におけるミトコンドリアの役割
医学のあゆみ, 2022, Not refereed, Invited
Last - ミトコンドリア機能の調節に関わるプロヒビチン複合体の解析
ミトコンドリアダイナミクス ～機能研究から疾患・老化まで～, 2021, Not refereed, Invited
Last - ミトコンドリアと免疫機能
FOOD Style 21, 2021, Not refereed, Invited
Last - 抗ウイルス自然免疫におけるミトコンドリアの応答ゾーン
福岡医誌, 2020, Refereed, Not invited
Last - プロテオミクスによるミトコンドリアタンパク質複合体の解析
生物物理, 2020, Refereed, Not invited
Lead - ミトコンドリアと抗ウイルス自然免疫シグナル
実験医学, 2019, Not refereed, Invited
Corresponding - ミトコンドリアを介した自然免疫応答
医学のあゆみ, 2018, Not refereed, Invited
Corresponding - インフルエンザウイルス感染に伴うミトコンドリア形態への影響
感染・炎症・免疫, 2017, Not refereed, Invited
Corresponding - Evaluation of Mitochondrial Respiratory Activity Using a FRET-based Indicator for Intracellular ATP
KOSHIBA Takumi; IMAMURA Hiromi
Seibutsu Butsuri, 2017, Refereed, Not invited
Lead - ミトコンドリア・ダイナミクスと抗ウイルス自然免疫
細胞, 2016, Not refereed, Invited
Corresponding - Interaction between Viral Proteins and Mitochondria
吉住 拓馬; 安川 開; 小柴 琢己
福岡医誌, 2016, Refereed, Not invited
Lead - Interaction between an Influenza A viral protein PB1-F2 and mitochondria
吉住 拓馬; 小柴 琢己
生化学, 2015, Refereed, Not invited
Last - 抗ウイルス自然免疫におけるミトコンドリアの役割
細胞工学, 2015, Not refereed, Invited
Corresponding - ウイルス自然免疫におけるミトコンドリアの生理的意義の解析
薬学研究の進歩, 2014, Refereed, Not invited
Corresponding - 生体発光共鳴エネルギー転移を用いた生細胞内でのミトコンリアタンパク質間相互作用解析
生物物理, 2014, Refereed, Not invited
Last - ミトコンドリアと抗ウイルス免疫
生化学, 2013, Not refereed, Invited
Corresponding - ミトコンドリア膜電位と抗ウイルス自然免疫
実験医学, 2011, Not refereed, Invited
Corresponding - Mitochondrial Dynamics and Cellular Antiviral Immunity
KOSHIBA Takumi; KUBOYAMA Misa
Seibutsu Butsuri, 2011, Refereed, Not invited
Lead - ミトコンドリア外膜タンパク質Mitofusin 2によるウイルス免疫制御機構
実験医学, 2010, Not refereed, Invited
Corresponding - ミトコンドリア外膜上でのウイルス免疫制御機構
生化学, 2010, Refereed, Not invited
Corresponding
- Mitochondrial-mediated antiviral innate immunity in mammals
University of Ulsan - Fukuoka University International Joint Symposium, Aug. 2023, Invited - 病原体と宿主ミトコンドリアとの相互作用
第13回 トランスポーター研究会（九州部会）, Aug. 2023, Invited - Mitochondria and parasite interactions
第45回 日本分子生物学会年会, Dec. 2022, Invited - ノンコーディングRNAによるミトコンドリア動態・代謝の調節
第20回 ミトコンドリア学会年会, Dec. 2021, Invited - 質量分析法によるミトコンドリアタンパク質複合体の解析
第59回 日本生物物理学会年会, Nov. 2021, Invited - miRNAを介したミトコンドリアの機能制御
第93回 日本生化学会大会, Sep. 2020, Invited - ミトコンドリアを介した抗ウイルス自然免疫
第42回 日本分子生物学会年会, Dec. 2019, Invited - Structural basis of mitochondrial scaffolds by prohibitin complexes
The 16th Conference of Asian Society for Mitochondrial Research and Medicine, Oct. 2019, Invited - ミトコンドリアにおける自然免疫応答ゾーンの解析
第92回 日本生化学会大会, Sep. 2019, Invited - Structure-function analysis of the prohibitin complexes in mitochondria
第71回 日本細胞生物学会大会, Jun. 2019, Invited - Mitochondrial-mediated antiviral innate immunity in mammals
The 15th Conference of Asian Society for Mitochondrial Research and Medicine, Nov. 2018, Invited - Mitochondrial-mediated antiviral innate immunity in mammals
The 3rd Asian Invertebrate Immunity Symposium 2018, Sep. 2018, Invited - Mitochondrial respiration and MAVS-mediated antiviral innate immunity
International Symposium on "Molecular Basis of Virus-Host Interactions", Oct. 2016, Invited - Mitochondrial-mediated antiviral innate immunity and oxidative phosphorylation
The 13th Conference of Asian Society for Mitochondrial Research and Medicine, Oct. 2016, Invited - Influenza A viral protein PB1-F2 and mitochondria
The 5th Annual World Congress of Molecular & Cell Biology, Apr. 2015, Invited - Mitochondria and antiviral signaling
The 4th International Symposium on Dynamics of Mitochondria, Oct. 2013, Invited - MAVS signaling and its inhibition
International Endotoxin and Innate Immunity Society Meeting 2012, Oct. 2012, Invited - Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling
Mitochondria Dynamics: from Mechanism to Disease, Sep. 2011, Invited
■ Affiliated academic society
- THE JAPANESE SOCIETY OF MITOCHONDRIAL RESEARCH AND MEDICINE
- THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
- THE JAPANESE BIOCHEMICAL SOCIETY
- THE BIOPHYSICAL SOCIETY OF JAPAN
- ミトコンドリア・ダイナミクスを介したストレス応答機構の解明
基盤研究（B）（一般）
2023 - 2027 - イムノコンドリア：自然免疫における中枢機能の解明
挑戦的研究（萌芽）
福岡大学
2021 - 2024 - ミトコンドリア内における自然免疫応答ゾーンの探索的研究
新学術領域研究（公募研究）
2020 - 2022 - ミトコンドリアにおける自然免疫応答ゾーンの解析
新学術領域研究（公募研究）
2018 - 2020 - ミトコンドリア・ダイナミクスの分子機構の解明と高次生理機能の考察
基盤研究（B）（一般）
2017 - 2020 - ミトコンドリアの動的な構造特性の改変；抗ウイルス自然免疫への影響
挑戦的研究（萌芽）
2017 - 2019 - ウイルスタンパク質とミトコンドリアとの相互作用解析
新学術領域研究（公募研究）
2015 - 2017 - 哺乳動物におけるミトコンドリア・ダイナミクスの分子基盤解析
基盤研究（B）（一般）
2014 - 2017 - 細胞内でのミトコンドリアの動きには酵素活性が必要なのか？
挑戦的萌芽研究
2014 - 2016 - ミトコンドリア・宿主間コミュニケーションによる抗ウイルス免疫機構の解析
新学術領域研究（公募研究）
2013 - 2015 - ミトコンドリアタンパク質を介した抗ウイルス自然免疫の構造生物学的研究
若手研究(B)
2012 - 2014 - The role of mitochondrial proteins involved in the innate immunity
Grant-in-Aid for Young Scientists (B)
Kyushu University
2008 - 2009 - リポ多糖認識に伴う生体膜融合及び分泌機構の分子基盤解析
若手研究(B)
九州大学
2006 - 2007
■ Media Coverage
