Regulation of Energy and Cholesterol Metabolisms During Fetal Leydig Cell Differentiation by DHH, PDGF, and Ad4BP/SF-1.
Miki Inoue; Fumiya Takahashi; Shogo Yanai; Keisuke Ishiwata; Tomoko Tanaka; Toshihiko Yanase; Yuichi Shima; Kazuhiko Nakabayashi; Kenichiro Hata; Ken-Ichirou Morohashi; Takashi Baba
Endocrinology, 2025年08月29日

SLC7A11/xCT-mediated Cystine Uptake Regulates Intracellular Glutathione and Promotes Antioxidant Defense in Lymphatic Endothelial Cells.
Shiho Hashiguchi; Tomoko Tanaka; Ryosuke Mano; Seiji Kondo; Shohta Kodama
Anticancer research, 2025年01月, 45(1):65 - 71
責任著者

NRF1-associated Dormancy and Glutamine-dependency in H295R Adrenocortical Cancer Cells
Yuta Horita; Tomoko Tanaka; Munechika Enjoji; Kenji Ohe
American Journal of Pharmacy and Health Research, 2024年12月, 12(12)

Co-culture of vascular endothelial cells enhances corticosterone production in steroid hormone-producing cells generated from adipose-derived mesenchymal stromal cells.
Toshikazu Niimi; Tomoko Tanaka; Chikao Aoyagi; Yasuhiro Onda; Shinichiro Nagamitsu; Shohta Kodama
Scientific reports, 2024年08月13日, 14(1):18804 - 18804
責任著者

Rescue of murine hind limb ischemia via angiogenesis and lymphangiogenesis promoted by cellular communication network factor 2.
Masayuki Shimizu; Gumpei Yoshimatsu; Yuichi Morita; Tomoko Tanaka; Naoaki Sakata; Hideaki Tagashira; Hideichi Wada; Shohta Kodama
Scientific reports, 2023年11月16日, 13(1):20029 - 20029

Differentiation of human adipose tissue-derived mesenchymal stromal cells into steroidogenic cells by adenovirus-mediated overexpression of NR5A1 and implantation into adrenal insufficient mice.
Chikao Aoyagi; Tomoko Tanaka; Nobuhiro Haga; Toshihiko Yanase; Shohta Kodama
Cytotherapy, 2023年08月, 25(8):866 - 876
責任著者

Induction of potassium channel regulator KCNE4 in a submandibular lymph node metastasis model.
Ryosuke Mano; Tomoko Tanaka; Shiho Hashiguchi; Hiroyuki Takahashi; Naoaki Sakata; Seiji Kondo; Shohta Kodama
Scientific reports, 2022年08月01日, 12(1):13208 - 13208
筆頭著者

Inhibition of NR5A1 Phosphorylation Alleviates a Transcriptional Suppression Defect Caused by a Novel NR0B1 Mutation.
Ichiro Abe; Tomoko Tanaka; Kenji Ohe; Hideyuki Fujii; Mai Nagata; Kentaro Ochi; Yuki Senda; Kaori Takeshita; Midori Koga; Tadachika Kudo; Munechika Enjoji; Toshihiko Yanase; Kunihisa Kobayashi
Journal of the Endocrine Society, 2022年06月01日, 6(6):bvac068
筆頭著者

CCN2-induced lymphangiogenesis is mediated by the integrin αvβ5-ERK pathway and regulated by DUSP6.
Shiho Hashiguchi; Tomoko Tanaka; Ryosuke Mano; Seiji Kondo; Shohta Kodama
Scientific reports, 2022年01月18日, 12(1):926 - 926
筆頭著者

Metformin affects alternative splicing of the estrogen receptor alpha gene in breast cancer cells
Yoshihiko Harada; Tomoko Tanaka; Yuriko Hamaguchi; Yuta Horita; Masayoshi Mori; Yusuke Murata; Munechika Enjoji; Kenji Ohe
American Journal of Pharmacy and Health Research, 2022年, 10(11)

Lymphangiogenesis and angiogenesis rescue murine ischemic hindlimb via transient receptor potential vanilloid 4.
Hideaki Yamada; Naoaki Sakata; Tomoko Tanaka; Hideaki Tagashira; Gumpei Yoshimatsu; Ryo Kawakami; Hideichi Wada; Takahiro Iwamoto; Shohta Kodama
Journal of pharmacological sciences, 2021年08月, 146(4):244 - 248

Xenotransplantation of neonatal porcine bone marrow-derived mesenchymal stem cells improves murine hind limb ischemia through lymphangiogenesis and angiogenesis.
Hideaki Yamada; Naoaki Sakata; Masuhiro Nishimura; Tomoko Tanaka; Masayuki Shimizu; Gumpei Yoshimatsu; Ryo Kawakami; Hideichi Wada; Osamu Sawamoto; Shinichi Matsumoto; Shohta Kodama
Xenotransplantation, 2021年07月, 28(4):e12693

High-mobility group box 2 protein is essential for the early phase of adipogenesis.
Hidetaka Morinaga; Yoshimi Muta; Tomoko Tanaka; Makito Tanabe; Yuriko Hamaguchi; Toshihiko Yanase
Biochemical and biophysical research communications, 2021年06月11日, 557:97 - 103

Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1β and islet cellular death.
Taisuke Matsuoka; Gumpei Yoshimatsu; Naoaki Sakata; Ryo Kawakami; Tomoko Tanaka; Teppei Yamada; Yoichiro Yoshida; Suguru Hasegawa; Shohta Kodama
Scientific reports, 2020年10月21日, 10(1):17920 - 17920

Activation of overexpressed glucagon-like peptide-1 receptor attenuates prostate cancer growth by inhibiting cell cycle progression.
Toru Shigeoka; Takashi Nomiyama; Takako Kawanami; Yuriko Hamaguchi; Tsuyoshi Horikawa; Tomoko Tanaka; Shinichiro Irie; Ryoko Motonaga; Nobuya Hamanoue; Makito Tanabe; Kazuki Nabeshima; Masatoshi Tanaka; Toshihiko Yanase; Daiji Kawanami
Journal of diabetes investigation, 2020年09月, 11(5):1137 - 1149

Extension of Survival in Bilaterally Adrenalectomized Mice by Implantation of SF-1/Ad4BP-Induced Steroidogenic Cells.
Tomoko Tanaka; Chikao Aoyagi; Kuniaki Mukai; Koshiro Nishimoto; Shohta Kodama; Toshihiko Yanase
Endocrinology, 2020年03月01日, 161(3)

Combined treatment with DPP-4 inhibitor linagliptin and SGLT2 inhibitor empagliflozin attenuates neointima formation after vascular injury in diabetic mice.
Hiroyuki Takahashi; Takashi Nomiyama; Yuichi Terawaki; Takeshi Horikawa; Takako Kawanami; Yuriko Hamaguchi; Tomoko Tanaka; Ryoko Motonaga; Takashi Fukuda; Makito Tanabe; Toshihiko Yanase
Biochemistry and biophysics reports, 2019年07月, 18:100640 - 100640

Circular IRE-type RNAs of the NR5A1 gene are formed in adrenocortical cells.
Kenji Ohe; Tomoko Tanaka; Yuta Horita; Yoshihiro Harada; Takafumi Yamasaki; Ichiro Abe; Makito Tanabe; Takashi Nomiyama; Kunihisa Kobayashi; Munechika Enjoji; Toshihiko Yanase
Biochemical and biophysical research communications, 2019年04月23日, 512(1):1 - 6
筆頭著者

Selective androgen receptor modulator, S42 has anabolic and anti-catabolic effects on cultured myotubes.
Yoshimi Muta; Tomoko Tanaka; Yuriko Hamaguchi; Nobuya Hamanoue; Ryoko Motonaga; Makito Tanabe; Takashi Nomiyama; Hajime Nawata; Toshihiko Yanase
Biochemistry and biophysics reports, 2019年03月, 17:177 - 181

GLP-1 Receptor Agonist Exendin-4 Attenuates NR4A Orphan Nuclear Receptor NOR1 Expression in Vascular Smooth Muscle Cells.
Hiroyuki Takahashi; Takashi Nomiyama; Yuichi Terawaki; Takako Kawanami; Yuriko Hamaguchi; Tomoko Tanaka; Makito Tanabe; Dennis Bruemmer; Toshihiko Yanase
Journal of atherosclerosis and thrombosis, 2019年02月01日, 26(2):183 - 197

HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells.
Kenji Ohe; Shinsuke Miyajima; Ichiro Abe; Tomoko Tanaka; Yuriko Hamaguchi; Yoshihiro Harada; Yuta Horita; Yuki Beppu; Fumiaki Ito; Takafumi Yamasaki; Hiroki Terai; Masayoshi Mori; Yusuke Murata; Makito Tanabe; Kenji Ashida; Kunihisa Kobayashi; Munechika Enjoji; Toshihiko Yanase; Nobuhiro Harada; Toshiaki Utsumi; Akila Mayeda
The Journal of steroid biochemistry and molecular biology, 2018年09月, 182:21 - 26

Expansion of transplanted islets in mice by co-transplantation with adipose tissue-derived mesenchymal stem cells.
Tomoko Tanaka; Daibo Kojima; Toshiyuki Mera; Masahito Matsumoto; Yohichi Yasunami; Toshihiko Yanase
Heliyon, 2018年05月, 4(5):e00632

Selective Androgen Receptor Modulator S42 Suppresses Prostate Cancer Cell Proliferation.
Takako Kawanami; Tomoko Tanaka; Yuriko Hamaguchi; Takashi Nomiyama; Hajime Nawata; Tosihiko Yanase
Endocrinology, 2018年04月01日, 159(4):1774 - 1792

HMGA1a Induces Alternative Splicing of the Estrogen Receptor-αlpha Gene by Trapping U1 snRNP to an Upstream Pseudo-5' Splice Site.
Kenji Ohe; Shinsuke Miyajima; Tomoko Tanaka; Yuriko Hamaguchi; Yoshihiro Harada; Yuta Horita; Yuki Beppu; Fumiaki Ito; Takafumi Yamasaki; Hiroki Terai; Masayoshi Mori; Yusuke Murata; Makito Tanabe; Ichiro Abe; Kenji Ashida; Kunihisa Kobayashi; Munechika Enjoji; Takashi Nomiyama; Toshihiko Yanase; Nobuhiro Harada; Toshiaki Utsumi; Akila Mayeda
Frontiers in molecular biosciences, 2018年, 5:52 - 52

Exendin-4, a Glucagonlike Peptide-1 Receptor Agonist, Attenuates Breast Cancer Growth by Inhibiting NF-κB Activation.
Chikayo Iwaya; Takashi Nomiyama; Shiho Komatsu; Takako Kawanami; Yoko Tsutsumi; Yuriko Hamaguchi; Tsuyoshi Horikawa; Yasuteru Yoshinaga; Shinichi Yamashita; Tomoko Tanaka; Yuichi Terawaki; Makito Tanabe; Kazuki Nabeshima; Akinori Iwasaki; Toshihiko Yanase
Endocrinology, 2017年12月01日, 158(12):4218 - 4232

Impact of metabolic disorders on prostate cancer growth: Androgen and insulin resistance perspectives.
Tashihiko Yanase; Takako Kawanami; Tomoko Tanaka; Makito Tanabe; Takashi Nomiyama
Reproductive medicine and biology, 2017年07月, 16(3):252 - 257

A higher score on the Aging Males' Symptoms scale is associated with insulin resistance in middle-aged men.
Nobuya Hamanoue; Makito Tanabe; Tomoko Tanaka; Yuko Akehi; Junji Murakami; Takashi Nomiyama; Toshihiko Yanase
Endocrine journal, 2017年05月30日, 64(5):521 - 530

Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.
Takashi Fukuda; Tomoko Tanaka; Yuriko Hamaguchi; Takako Kawanami; Takashi Nomiyama; Toshihiko Yanase
PloS one, 2016年, 11(10):e0164131
筆頭著者

Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth.
Yoko Tsutsumi; Takashi Nomiyama; Takako Kawanami; Yuriko Hamaguchi; Yuichi Terawaki; Tomoko Tanaka; Kunitaka Murase; Ryoko Motonaga; Makito Tanabe; Toshihiko Yanase
PloS one, 2015年, 10(10):e0139709

Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury.
Yuichi Terawaki; Takashi Nomiyama; Takako Kawanami; Yuriko Hamaguchi; Hiroyuki Takahashi; Tomoko Tanaka; Kunitaka Murase; Ryoko Nagaishi; Makito Tanabe; Toshihiko Yanase
Cardiovascular diabetology, 2014年11月19日, 13:154 - 154

Exendin-4, a GLP-1 Receptor Agonist, Attenuates Prostate Cancer Growth
Takashi Nomiyama; Takako Kawanami; Shinichiro Irie; Yuriko Hamaguchi; Yuichi Terawaki; Kunitaka Murase; Yoko Tsutsumi; Ryoko Nagaishi; Makito Tanabe; Hidetaka Morinaga; Tomoko Tanaka; Makio Mizoguchi; Kazuki Nabeshima; Masatoshi Tanaka; Toshihiko Yanase
DIABETES, 2014年11月, 63(11):3891 - 3905, 査読有り

Dihydrotestosterone inhibits lectin-like oxidized-LDL receptor-1 expression in aortic endothelial cells via a NF-κB/AP-1-mediated mechanism.
Yang Qiu; Tomoko Tanaka; Hajime Nawata; Toshihiko Yanase
Endocrinology, 2012年07月, 153(7):3405 - 15

Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development.
Yang Qiu; Toshihiko Yanase; Haidi Hu; Tomoko Tanaka; Yoshihiro Nishi; Min Liu; Katsuo Sueishi; Tatsuya Sawamura; Hajime Nawata
Endocrinology, 2010年07月, 151(7):3307 - 16

A novel synthetic androgen receptor ligand, S42, works as a selective androgen receptor modulator and possesses metabolic effects with little impact on the prostate.
Liu Min; Toshihiko Yanase; Tomoko Tanaka; WuQiang Fan; Masatoshi Nomura; Hisaya Kawate; Taijiro Okabe; Ryoichi Takayanagi; Hajime Nawata
Endocrinology, 2009年12月, 150(12):5606 - 16

Adipose tissue-derived and bone marrow-derived mesenchymal cells develop into different lineage of steroidogenic cells by forced expression of steroidogenic factor 1.
Shigeki Gondo; Taijiro Okabe; Tomoko Tanaka; Hidetaka Morinaga; Masatoshi Nomura; Ryoichi Takayanagi; Hajime Nawata; Toshihiko Yanase
Endocrinology, 2008年09月, 149(9):4717 - 25

Methylation of a conserved intronic CpG island of mouse SF-1 is associated with cell-specific expression of SF-1 in a culture system but not with tissue-specific expression.
Hisao Shirohzu; Taijiro Okabe; Shigeki Gondo; Tomoko Tanaka; Kenji Ohe; Hidetaka Morinaga; Hisaya Kawate; Masatoshi Nomura; Ryoichi Takayanagi; Hajime Nawata; Toshihiko Yanase
Biochemical and biophysical research communications, 2008年05月09日, 369(3):862 - 7

Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells.
Tomoko Tanaka; Shigeki Gondo; Taijiro Okabe; Kenji Ohe; Hisao Shirohzu; Hidetaka Morinaga; Masatoshi Nomura; Kenzaburo Tani; Ryoichi Takayanagi; Hajime Nawata; Toshihiko Yanase
Journal of molecular endocrinology, 2007年11月, 39(5):343 - 50

Modification of glucocorticoid sensitivity by MAP kinase signaling pathways in glucocorticoid-induced T-cell apoptosis.
Tomoko Tanaka; Taijiro Okabe; Shigeki Gondo; Mitsue Fukuda; Masahiro Yamamoto; Tsukuru Umemura; Kenzaburo Tani; Masatoshi Nomura; Kiminobu Goto; Toshihiko Yanase; Hajime Nawata
Experimental hematology, 2006年11月, 34(11):1542 - 52

Differentiation and regeneration of adrenal tissues: An initial step toward regeneration therapy for steroid insufficiency.
Toshihiko Yanase; Shigeki Gondo; Taijiro Okabe; Tomoko Tanaka; Hisao Shirohzu; Wuqiang Fan; Koichi Oba; Hidetaka Morinaga; Masatoshi Nomura; Kenji Ohe; Hajime Nawata
Endocrine journal, 2006年08月, 53(4):449 - 59

SF-1/Ad4BP transforms primary long-term cultured bone marrow cells into ACTH-responsive steroidogenic cells.
Shigeki Gondo; Toshihiko Yanase; Taijiro Okabe; Tomoko Tanaka; Hidetaka Morinaga; Masatoshi Nomura; Kiminobu Goto; Hajime Nawata
Genes to cells : devoted to molecular & cellular mechanisms, 2004年12月, 9(12):1239 - 47

Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells.
Chizu Mukasa; Masatoshi Nomura; Tomoko Tanaka; Kimitaka Tanaka; Yoshihiro Nishi; Taijiro Okabe; Kiminobu Goto; Toshihiko Yanase; Hajime Nawata
Endocrinology, 2003年04月, 144(4):1603 - 11

副腎皮質癌治療の標的分子としての核内受容体NR5A1(SF-1/Ad4BP)—Targeting the nuclear receptor, NR5A1 (Ad4BP/SF-1), for treating adrenocortical carcinoma
大江 賢治; 堀田 裕太; 田中 智子
糖尿病・内分泌代謝科 = Diabetology, endocrinology & metabolology / 糖尿病・内分泌代謝科編集委員会 編, 2021年07月, 53(1):85 - 89

ヒト副腎皮質に発現しているIREタイプの新規環状RNAの発見
田中 智子; 大江 賢治
Medical Science Digest, 2021年, 47:117 - 118

男性更年期障害:診療の現状と基盤的臨床・基礎研究の進展
柳瀬 敏彦; 村瀬 邦崇; 田中 智子; 野見山 崇
Medical Science Digest (MSD), 2011年, 37:102 - 105

「サルコペニアの診かた」アンドロゲンとサルコペニア
野見山 崇; 村瀬 邦崇; 田中 智子; 柳瀬 敏彦
Modern Medicine, 2011年, 31(11):1370 - 1373

性ホルモン受容体とアデイポサイエンスアデイ
柳瀬 敏彦; 田中 智子
ポサイエンス 7, 2010年, :113 - 117

ステロイド産生細胞研究の現状
田中 智子
日本生殖内分泌学会雑誌 14巻, 2009年, 14:51 - 53

グルココルチコイドによるT細胞アポトーシス誘導とグルココルチコイド受容体によるNF-кB抑制との関連性について
岡部 泰二郎; 田中 智子; 権藤 重喜; 野村 政壽; 後藤 公宣; 柳瀬 敏彦; 名和田 新
ホルモンと臨牀, 2003年03月10日, 51:234 - 235

Screening for Therapeutic Targets to Suppress GH Production and Proliferation in AIP Mutant GH-Producing Cells
Tomoko Tanaka; Takashi Fukuda; Hideyuki Fujii; Daiji Kawanami; Shohta Kodama; Toshihiko Yanase
ENDO2025, 2025年07月12日

A Splicing Modulator Inhibits Proliferation and Steroid Production of H295R Adrenocortical Cancer Cells
Tomoko Tanaka; Kenji Ohe; Toshihiko Yanase; Shohta Kodama
ENDO2024, 2024年06月02日

Implantation of Steroidogenic Cells Derived from Human Adipose-derived Stem Cells Extends Survival in a Mouse Model of Adrenal Insufficiency
Tomoko Tanaka; Chikao Aoyagi; Toshihiko Yanase; Shohta Kodama
ENDO2022, 2022年06月11日

CX-4945 as a Potential Drug for Adrenocortical Carcinoma That Induces Multiple Exon-Skipping and Circular RNA of NR5A1
Tomoko Tanaka; Kenji Ohe; Takashi Nomiyama; Toshihiko Yanase
ENDO2019, 2019年03月23日

Steroid Complement by the Transplantation of SF-1/Ad4BP-induced Steroidogenic Cells in Mice with Adrenal Insufficiency
Tomoko Tanaka; Shohta Kodama; Toshihiko Yanase
ENDO2016, 2016年04月01日

Expansion of Transplanted Islets by Co-transplantaion of Adipose Tissue-derived Mesenchymal Stem cells in Mice
Tomoko Tanaka; Takeshi Itoh; Masahito Matsumoto; Daibo Kojima; Toshiyuki Mera; Hitomi Nishinakamura; Shohta Kodama; Junko Ono; Toshihiko Yanase; Yohichi Yasunami
American Diabetes Association 74th Scientific Sessions, 2014年06月16日

Steroidogenic cells regenerated from mesenchymal stem cells
Tomoko Tanaka
14th International Congress of Endocrinology, Official Satellite Symposia, 2010年03月30日

遺伝子改変医療用ブタ膵島と間葉系幹細胞共移植による異種移植免疫寛容を目指して
日本学術振興会, 科学研究費助成事業, 基盤研究(B)
福岡大学
2024年04月01日 - 2027年03月31日

グルコセンサーを介した血糖高感受性移植膵島の創出 -組織工学的手法を用いて-
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
2020年04月01日 - 2023年03月31日

ステロイド産生細胞における環状構造RNAの意義の解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
2020年04月01日 - 2023年03月31日

CK2阻害剤による副腎皮質癌やステロイド産生副腎腫瘍の新たな治療法の開発
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
2018年04月01日 - 2021年03月31日

細胞移植によるステロイドホルモン補充についての検討
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
2016年04月01日 - 2019年03月31日

生活習慣病発症、治療基盤としてのアンドロゲン、SARMに関する包括的研究
日本学術振興会, 科学研究費助成事業, 基盤研究(B)
福岡大学
2015年04月01日 - 2018年03月31日

生活習慣病創薬としての新規選択的アンドロゲン受容体修飾剤Ｓ４２に関する研究
日本学術振興会, 科学研究費助成事業, 基盤研究(B)
福岡大学
2011年04月01日 - 2014年03月31日

生活習慣病発症基盤としてのアンドロゲンの意義に関する基礎的、臨床的研究
日本学術振興会, 科学研究費助成事業, 基盤研究(B)
福岡大学
2008年 - 2010年

間葉系幹細胞からのステロイド産生細胞への分化誘導法の確立および分化機序の解明
日本学術振興会, 科学研究費助成事業, 若手研究(B)
九州大学
2008年 - 2009年

副腎または性腺ステロイド産生細胞への分化に関与する因子のスクリーニング
日本学術振興会, 科学研究費助成事業, 若手研究(B)
九州大学
2006年 - 2007年