Regulation of Energy and Cholesterol Metabolisms During Fetal Leydig Cell Differentiation by DHH, PDGF, and Ad4BP/SF-1.
Miki Inoue; Fumiya Takahashi; Shogo Yanai; Keisuke Ishiwata; Tomoko Tanaka; Toshihiko Yanase; Yuichi Shima; Kazuhiko Nakabayashi; Kenichiro Hata; Ken-Ichirou Morohashi; Takashi Baba
Endocrinology, 29 Aug. 2025

SLC7A11/xCT-mediated Cystine Uptake Regulates Intracellular Glutathione and Promotes Antioxidant Defense in Lymphatic Endothelial Cells.
Shiho Hashiguchi; Tomoko Tanaka; Ryosuke Mano; Seiji Kondo; Shohta Kodama
Anticancer research, Jan. 2025, 45(1):65 - 71
Corresponding

NRF1-associated Dormancy and Glutamine-dependency in H295R Adrenocortical Cancer Cells
Yuta Horita; Tomoko Tanaka; Munechika Enjoji; Kenji Ohe
American Journal of Pharmacy and Health Research, Dec. 2024, 12(12)

Co-culture of vascular endothelial cells enhances corticosterone production in steroid hormone-producing cells generated from adipose-derived mesenchymal stromal cells.
Toshikazu Niimi; Tomoko Tanaka; Chikao Aoyagi; Yasuhiro Onda; Shinichiro Nagamitsu; Shohta Kodama
Scientific reports, 13 Aug. 2024, 14(1):18804 - 18804
Corresponding

Rescue of murine hind limb ischemia via angiogenesis and lymphangiogenesis promoted by cellular communication network factor 2.
Masayuki Shimizu; Gumpei Yoshimatsu; Yuichi Morita; Tomoko Tanaka; Naoaki Sakata; Hideaki Tagashira; Hideichi Wada; Shohta Kodama
Scientific reports, 16 Nov. 2023, 13(1):20029 - 20029

Differentiation of human adipose tissue-derived mesenchymal stromal cells into steroidogenic cells by adenovirus-mediated overexpression of NR5A1 and implantation into adrenal insufficient mice.
Chikao Aoyagi; Tomoko Tanaka; Nobuhiro Haga; Toshihiko Yanase; Shohta Kodama
Cytotherapy, Aug. 2023, 25(8):866 - 876
Corresponding

Induction of potassium channel regulator KCNE4 in a submandibular lymph node metastasis model.
Ryosuke Mano; Tomoko Tanaka; Shiho Hashiguchi; Hiroyuki Takahashi; Naoaki Sakata; Seiji Kondo; Shohta Kodama
Scientific reports, 01 Aug. 2022, 12(1):13208 - 13208
Lead

Inhibition of NR5A1 Phosphorylation Alleviates a Transcriptional Suppression Defect Caused by a Novel NR0B1 Mutation.
Ichiro Abe; Tomoko Tanaka; Kenji Ohe; Hideyuki Fujii; Mai Nagata; Kentaro Ochi; Yuki Senda; Kaori Takeshita; Midori Koga; Tadachika Kudo; Munechika Enjoji; Toshihiko Yanase; Kunihisa Kobayashi
Journal of the Endocrine Society, 01 Jun. 2022, 6(6):bvac068
Lead

CCN2-induced lymphangiogenesis is mediated by the integrin αvβ5-ERK pathway and regulated by DUSP6.
Shiho Hashiguchi; Tomoko Tanaka; Ryosuke Mano; Seiji Kondo; Shohta Kodama
Scientific reports, 18 Jan. 2022, 12(1):926 - 926
Lead

Metformin affects alternative splicing of the estrogen receptor alpha gene in breast cancer cells
Yoshihiko Harada; Tomoko Tanaka; Yuriko Hamaguchi; Yuta Horita; Masayoshi Mori; Yusuke Murata; Munechika Enjoji; Kenji Ohe
American Journal of Pharmacy and Health Research, 2022, 10(11)

Lymphangiogenesis and angiogenesis rescue murine ischemic hindlimb via transient receptor potential vanilloid 4.
Hideaki Yamada; Naoaki Sakata; Tomoko Tanaka; Hideaki Tagashira; Gumpei Yoshimatsu; Ryo Kawakami; Hideichi Wada; Takahiro Iwamoto; Shohta Kodama
Journal of pharmacological sciences, Aug. 2021, 146(4):244 - 248

Xenotransplantation of neonatal porcine bone marrow-derived mesenchymal stem cells improves murine hind limb ischemia through lymphangiogenesis and angiogenesis.
Hideaki Yamada; Naoaki Sakata; Masuhiro Nishimura; Tomoko Tanaka; Masayuki Shimizu; Gumpei Yoshimatsu; Ryo Kawakami; Hideichi Wada; Osamu Sawamoto; Shinichi Matsumoto; Shohta Kodama
Xenotransplantation, Jul. 2021, 28(4):e12693

High-mobility group box 2 protein is essential for the early phase of adipogenesis.
Hidetaka Morinaga; Yoshimi Muta; Tomoko Tanaka; Makito Tanabe; Yuriko Hamaguchi; Toshihiko Yanase
Biochemical and biophysical research communications, 11 Jun. 2021, 557:97 - 103

Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1β and islet cellular death.
Taisuke Matsuoka; Gumpei Yoshimatsu; Naoaki Sakata; Ryo Kawakami; Tomoko Tanaka; Teppei Yamada; Yoichiro Yoshida; Suguru Hasegawa; Shohta Kodama
Scientific reports, 21 Oct. 2020, 10(1):17920 - 17920

Activation of overexpressed glucagon-like peptide-1 receptor attenuates prostate cancer growth by inhibiting cell cycle progression.
Toru Shigeoka; Takashi Nomiyama; Takako Kawanami; Yuriko Hamaguchi; Tsuyoshi Horikawa; Tomoko Tanaka; Shinichiro Irie; Ryoko Motonaga; Nobuya Hamanoue; Makito Tanabe; Kazuki Nabeshima; Masatoshi Tanaka; Toshihiko Yanase; Daiji Kawanami
Journal of diabetes investigation, Sep. 2020, 11(5):1137 - 1149

Extension of Survival in Bilaterally Adrenalectomized Mice by Implantation of SF-1/Ad4BP-Induced Steroidogenic Cells.
Tomoko Tanaka; Chikao Aoyagi; Kuniaki Mukai; Koshiro Nishimoto; Shohta Kodama; Toshihiko Yanase
Endocrinology, 01 Mar. 2020, 161(3)

Combined treatment with DPP-4 inhibitor linagliptin and SGLT2 inhibitor empagliflozin attenuates neointima formation after vascular injury in diabetic mice.
Hiroyuki Takahashi; Takashi Nomiyama; Yuichi Terawaki; Takeshi Horikawa; Takako Kawanami; Yuriko Hamaguchi; Tomoko Tanaka; Ryoko Motonaga; Takashi Fukuda; Makito Tanabe; Toshihiko Yanase
Biochemistry and biophysics reports, Jul. 2019, 18:100640 - 100640

Circular IRE-type RNAs of the NR5A1 gene are formed in adrenocortical cells.
Kenji Ohe; Tomoko Tanaka; Yuta Horita; Yoshihiro Harada; Takafumi Yamasaki; Ichiro Abe; Makito Tanabe; Takashi Nomiyama; Kunihisa Kobayashi; Munechika Enjoji; Toshihiko Yanase
Biochemical and biophysical research communications, 23 Apr. 2019, 512(1):1 - 6
Lead

Selective androgen receptor modulator, S42 has anabolic and anti-catabolic effects on cultured myotubes.
Yoshimi Muta; Tomoko Tanaka; Yuriko Hamaguchi; Nobuya Hamanoue; Ryoko Motonaga; Makito Tanabe; Takashi Nomiyama; Hajime Nawata; Toshihiko Yanase
Biochemistry and biophysics reports, Mar. 2019, 17:177 - 181

GLP-1 Receptor Agonist Exendin-4 Attenuates NR4A Orphan Nuclear Receptor NOR1 Expression in Vascular Smooth Muscle Cells.
Hiroyuki Takahashi; Takashi Nomiyama; Yuichi Terawaki; Takako Kawanami; Yuriko Hamaguchi; Tomoko Tanaka; Makito Tanabe; Dennis Bruemmer; Toshihiko Yanase
Journal of atherosclerosis and thrombosis, 01 Feb. 2019, 26(2):183 - 197

HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells.
Kenji Ohe; Shinsuke Miyajima; Ichiro Abe; Tomoko Tanaka; Yuriko Hamaguchi; Yoshihiro Harada; Yuta Horita; Yuki Beppu; Fumiaki Ito; Takafumi Yamasaki; Hiroki Terai; Masayoshi Mori; Yusuke Murata; Makito Tanabe; Kenji Ashida; Kunihisa Kobayashi; Munechika Enjoji; Toshihiko Yanase; Nobuhiro Harada; Toshiaki Utsumi; Akila Mayeda
The Journal of steroid biochemistry and molecular biology, Sep. 2018, 182:21 - 26

Expansion of transplanted islets in mice by co-transplantation with adipose tissue-derived mesenchymal stem cells.
Tomoko Tanaka; Daibo Kojima; Toshiyuki Mera; Masahito Matsumoto; Yohichi Yasunami; Toshihiko Yanase
Heliyon, May 2018, 4(5):e00632

Selective Androgen Receptor Modulator S42 Suppresses Prostate Cancer Cell Proliferation.
Takako Kawanami; Tomoko Tanaka; Yuriko Hamaguchi; Takashi Nomiyama; Hajime Nawata; Tosihiko Yanase
Endocrinology, 01 Apr. 2018, 159(4):1774 - 1792

HMGA1a Induces Alternative Splicing of the Estrogen Receptor-αlpha Gene by Trapping U1 snRNP to an Upstream Pseudo-5' Splice Site.
Kenji Ohe; Shinsuke Miyajima; Tomoko Tanaka; Yuriko Hamaguchi; Yoshihiro Harada; Yuta Horita; Yuki Beppu; Fumiaki Ito; Takafumi Yamasaki; Hiroki Terai; Masayoshi Mori; Yusuke Murata; Makito Tanabe; Ichiro Abe; Kenji Ashida; Kunihisa Kobayashi; Munechika Enjoji; Takashi Nomiyama; Toshihiko Yanase; Nobuhiro Harada; Toshiaki Utsumi; Akila Mayeda
Frontiers in molecular biosciences, 2018, 5:52 - 52

Exendin-4, a Glucagonlike Peptide-1 Receptor Agonist, Attenuates Breast Cancer Growth by Inhibiting NF-κB Activation.
Chikayo Iwaya; Takashi Nomiyama; Shiho Komatsu; Takako Kawanami; Yoko Tsutsumi; Yuriko Hamaguchi; Tsuyoshi Horikawa; Yasuteru Yoshinaga; Shinichi Yamashita; Tomoko Tanaka; Yuichi Terawaki; Makito Tanabe; Kazuki Nabeshima; Akinori Iwasaki; Toshihiko Yanase
Endocrinology, 01 Dec. 2017, 158(12):4218 - 4232

Impact of metabolic disorders on prostate cancer growth: Androgen and insulin resistance perspectives.
Tashihiko Yanase; Takako Kawanami; Tomoko Tanaka; Makito Tanabe; Takashi Nomiyama
Reproductive medicine and biology, Jul. 2017, 16(3):252 - 257

A higher score on the Aging Males' Symptoms scale is associated with insulin resistance in middle-aged men.
Nobuya Hamanoue; Makito Tanabe; Tomoko Tanaka; Yuko Akehi; Junji Murakami; Takashi Nomiyama; Toshihiko Yanase
Endocrine journal, 30 May 2017, 64(5):521 - 530

Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.
Takashi Fukuda; Tomoko Tanaka; Yuriko Hamaguchi; Takako Kawanami; Takashi Nomiyama; Toshihiko Yanase
PloS one, 2016, 11(10):e0164131
Lead

Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth.
Yoko Tsutsumi; Takashi Nomiyama; Takako Kawanami; Yuriko Hamaguchi; Yuichi Terawaki; Tomoko Tanaka; Kunitaka Murase; Ryoko Motonaga; Makito Tanabe; Toshihiko Yanase
PloS one, 2015, 10(10):e0139709

Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury.
Yuichi Terawaki; Takashi Nomiyama; Takako Kawanami; Yuriko Hamaguchi; Hiroyuki Takahashi; Tomoko Tanaka; Kunitaka Murase; Ryoko Nagaishi; Makito Tanabe; Toshihiko Yanase
Cardiovascular diabetology, 19 Nov. 2014, 13:154 - 154

Exendin-4, a GLP-1 Receptor Agonist, Attenuates Prostate Cancer Growth
Takashi Nomiyama; Takako Kawanami; Shinichiro Irie; Yuriko Hamaguchi; Yuichi Terawaki; Kunitaka Murase; Yoko Tsutsumi; Ryoko Nagaishi; Makito Tanabe; Hidetaka Morinaga; Tomoko Tanaka; Makio Mizoguchi; Kazuki Nabeshima; Masatoshi Tanaka; Toshihiko Yanase
DIABETES, Nov. 2014, 63(11):3891 - 3905, Refereed

Dihydrotestosterone inhibits lectin-like oxidized-LDL receptor-1 expression in aortic endothelial cells via a NF-κB/AP-1-mediated mechanism.
Yang Qiu; Tomoko Tanaka; Hajime Nawata; Toshihiko Yanase
Endocrinology, Jul. 2012, 153(7):3405 - 15

Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development.
Yang Qiu; Toshihiko Yanase; Haidi Hu; Tomoko Tanaka; Yoshihiro Nishi; Min Liu; Katsuo Sueishi; Tatsuya Sawamura; Hajime Nawata
Endocrinology, Jul. 2010, 151(7):3307 - 16

A novel synthetic androgen receptor ligand, S42, works as a selective androgen receptor modulator and possesses metabolic effects with little impact on the prostate.
Liu Min; Toshihiko Yanase; Tomoko Tanaka; WuQiang Fan; Masatoshi Nomura; Hisaya Kawate; Taijiro Okabe; Ryoichi Takayanagi; Hajime Nawata
Endocrinology, Dec. 2009, 150(12):5606 - 16

Adipose tissue-derived and bone marrow-derived mesenchymal cells develop into different lineage of steroidogenic cells by forced expression of steroidogenic factor 1.
Shigeki Gondo; Taijiro Okabe; Tomoko Tanaka; Hidetaka Morinaga; Masatoshi Nomura; Ryoichi Takayanagi; Hajime Nawata; Toshihiko Yanase
Endocrinology, Sep. 2008, 149(9):4717 - 25

Methylation of a conserved intronic CpG island of mouse SF-1 is associated with cell-specific expression of SF-1 in a culture system but not with tissue-specific expression.
Hisao Shirohzu; Taijiro Okabe; Shigeki Gondo; Tomoko Tanaka; Kenji Ohe; Hidetaka Morinaga; Hisaya Kawate; Masatoshi Nomura; Ryoichi Takayanagi; Hajime Nawata; Toshihiko Yanase
Biochemical and biophysical research communications, 09 May 2008, 369(3):862 - 7

Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells.
Tomoko Tanaka; Shigeki Gondo; Taijiro Okabe; Kenji Ohe; Hisao Shirohzu; Hidetaka Morinaga; Masatoshi Nomura; Kenzaburo Tani; Ryoichi Takayanagi; Hajime Nawata; Toshihiko Yanase
Journal of molecular endocrinology, Nov. 2007, 39(5):343 - 50

Modification of glucocorticoid sensitivity by MAP kinase signaling pathways in glucocorticoid-induced T-cell apoptosis.
Tomoko Tanaka; Taijiro Okabe; Shigeki Gondo; Mitsue Fukuda; Masahiro Yamamoto; Tsukuru Umemura; Kenzaburo Tani; Masatoshi Nomura; Kiminobu Goto; Toshihiko Yanase; Hajime Nawata
Experimental hematology, Nov. 2006, 34(11):1542 - 52

Differentiation and regeneration of adrenal tissues: An initial step toward regeneration therapy for steroid insufficiency.
Toshihiko Yanase; Shigeki Gondo; Taijiro Okabe; Tomoko Tanaka; Hisao Shirohzu; Wuqiang Fan; Koichi Oba; Hidetaka Morinaga; Masatoshi Nomura; Kenji Ohe; Hajime Nawata
Endocrine journal, Aug. 2006, 53(4):449 - 59

SF-1/Ad4BP transforms primary long-term cultured bone marrow cells into ACTH-responsive steroidogenic cells.
Shigeki Gondo; Toshihiko Yanase; Taijiro Okabe; Tomoko Tanaka; Hidetaka Morinaga; Masatoshi Nomura; Kiminobu Goto; Hajime Nawata
Genes to cells : devoted to molecular & cellular mechanisms, Dec. 2004, 9(12):1239 - 47

Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells.
Chizu Mukasa; Masatoshi Nomura; Tomoko Tanaka; Kimitaka Tanaka; Yoshihiro Nishi; Taijiro Okabe; Kiminobu Goto; Toshihiko Yanase; Hajime Nawata
Endocrinology, Apr. 2003, 144(4):1603 - 11

副腎皮質癌治療の標的分子としての核内受容体NR5A1(SF-1/Ad4BP)—Targeting the nuclear receptor, NR5A1 (Ad4BP/SF-1), for treating adrenocortical carcinoma
大江 賢治; 堀田 裕太; 田中 智子
糖尿病・内分泌代謝科 = Diabetology, endocrinology & metabolology / 糖尿病・内分泌代謝科編集委員会 編, Jul. 2021, 53(1):85 - 89

ヒト副腎皮質に発現しているIREタイプの新規環状RNAの発見
田中 智子; 大江 賢治
Medical Science Digest, 2021, 47:117 - 118

男性更年期障害:診療の現状と基盤的臨床・基礎研究の進展
柳瀬 敏彦; 村瀬 邦崇; 田中 智子; 野見山 崇
Medical Science Digest (MSD), 2011, 37:102 - 105

「サルコペニアの診かた」アンドロゲンとサルコペニア
野見山 崇; 村瀬 邦崇; 田中 智子; 柳瀬 敏彦
Modern Medicine, 2011, 31(11):1370 - 1373

性ホルモン受容体とアデイポサイエンスアデイ
柳瀬 敏彦; 田中 智子
ポサイエンス 7, 2010, :113 - 117

ステロイド産生細胞研究の現状
田中 智子
日本生殖内分泌学会雑誌 14巻, 2009, 14:51 - 53

グルココルチコイドによるT細胞アポトーシス誘導とグルココルチコイド受容体によるNF-кB抑制との関連性について
岡部 泰二郎; 田中 智子; 権藤 重喜; 野村 政壽; 後藤 公宣; 柳瀬 敏彦; 名和田 新
ホルモンと臨牀, 10 Mar. 2003, 51:234 - 235

Screening for Therapeutic Targets to Suppress GH Production and Proliferation in AIP Mutant GH-Producing Cells
Tomoko Tanaka; Takashi Fukuda; Hideyuki Fujii; Daiji Kawanami; Shohta Kodama; Toshihiko Yanase
ENDO2025, 12 Jul. 2025

A Splicing Modulator Inhibits Proliferation and Steroid Production of H295R Adrenocortical Cancer Cells
Tomoko Tanaka; Kenji Ohe; Toshihiko Yanase; Shohta Kodama
ENDO2024, 02 Jun. 2024

Implantation of Steroidogenic Cells Derived from Human Adipose-derived Stem Cells Extends Survival in a Mouse Model of Adrenal Insufficiency
Tomoko Tanaka; Chikao Aoyagi; Toshihiko Yanase; Shohta Kodama
ENDO2022, 11 Jun. 2022

CX-4945 as a Potential Drug for Adrenocortical Carcinoma That Induces Multiple Exon-Skipping and Circular RNA of NR5A1
Tomoko Tanaka; Kenji Ohe; Takashi Nomiyama; Toshihiko Yanase
ENDO2019, 23 Mar. 2019

Steroid Complement by the Transplantation of SF-1/Ad4BP-induced Steroidogenic Cells in Mice with Adrenal Insufficiency
Tomoko Tanaka; Shohta Kodama; Toshihiko Yanase
ENDO2016, 01 Apr. 2016

Expansion of Transplanted Islets by Co-transplantaion of Adipose Tissue-derived Mesenchymal Stem cells in Mice
Tomoko Tanaka; Takeshi Itoh; Masahito Matsumoto; Daibo Kojima; Toshiyuki Mera; Hitomi Nishinakamura; Shohta Kodama; Junko Ono; Toshihiko Yanase; Yohichi Yasunami
American Diabetes Association 74th Scientific Sessions, 16 Jun. 2014

Steroidogenic cells regenerated from mesenchymal stem cells
Tomoko Tanaka
14th International Congress of Endocrinology, Official Satellite Symposia, 30 Mar. 2010

遺伝子改変医療用ブタ膵島と間葉系幹細胞共移植による異種移植免疫寛容を目指して
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Fukuoka University
01 Apr. 2024 - 31 Mar. 2027

グルコセンサーを介した血糖高感受性移植膵島の創出 -組織工学的手法を用いて-
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2020 - 31 Mar. 2023

ステロイド産生細胞における環状構造RNAの意義の解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2020 - 31 Mar. 2023

CK2阻害剤による副腎皮質癌やステロイド産生副腎腫瘍の新たな治療法の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2018 - 31 Mar. 2021

細胞移植によるステロイドホルモン補充についての検討
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2016 - 31 Mar. 2019

生活習慣病発症、治療基盤としてのアンドロゲン、SARMに関する包括的研究
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Fukuoka University
01 Apr. 2015 - 31 Mar. 2018

生活習慣病創薬としての新規選択的アンドロゲン受容体修飾剤Ｓ４２に関する研究
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Fukuoka University
01 Apr. 2011 - 31 Mar. 2014

生活習慣病発症基盤としてのアンドロゲンの意義に関する基礎的、臨床的研究
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Kyushu University
2008 - 2010

間葉系幹細胞からのステロイド産生細胞への分化誘導法の確立および分化機序の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B)
Kyushu University
2008 - 2009

副腎または性腺ステロイド産生細胞への分化に関与する因子のスクリーニング
日本学術振興会, 科学研究費助成事業, 若手研究(B)
九州大学
2006 - 2007