The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes.
Ishikura S; Nagai M; Tsunoda T; Nishi K; Tanaka Y; Koyanagi M; Shirasawa S
J. Cell Biochem., 2021, 122(6):626 - 638, Refereed

Zfat is indispensable for the development of erythroid cells in the fetal liver.
Doi K; Tsunoda T; Koyanagi M; Tanaka Y; Yamano S; Fujikane A; Nishi K; Ishikura S; Shirasawa S
Anticancer Res., 2019, 39(8):4495 - 4502, Refereed

Zfat expression in ZsGreen reporter gene knock-in mice: Implications for a novel function of Zfat in definitive erythropoiesis.
Tsunoda T; Doi K; Ishikura S; Luo H; Nishi K; Matsuzaki H; Koyanagi M; Tanaka Y; Okamura T; Shirasawa S
Int. J. Mol. Med., 2018, 42(5):2595 - 2603, Refereed

Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells
Shuhei Ishikura; Toshiyuki Tsunoda; Kazuhiko Nakabayashi; Keiko Doi; Midori Koyanagi; Keiko Hayashi; Tomoko Kawai; Yoko Tanaka; Yuri Iwaihara; Hao Luo; Kensuke Nishi; Tadashi Okamura; Senji Shirasawa
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, Nov. 2016, 1859(11):1398 - 1410, Refereed

The Nuclear Zinc Finger Protein Zfat Maintains Fox01 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway
Shuhei Ishikura; Yuri Iwaihara; Yoko Tanaka; Hao Luo; Kensuke Nishi; Keiko Doi; Midori Koyanagi; Tadashi Okamura; Toshiyuki Tsunoda; Senji Shirasawa
JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2016, 291(29):15282 - 15291, Refereed

Zfat-deficient CD4+ CD8+ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.
Ishikura S; Ogawa M; Doi K; Matsuzaki H; Iwaihara Y; Tanaka Y; Tsunoda T; Hideshima H; Okamura T; Shirasawa S
J. Cell Biochem., 2015, 116(1):149 - 157, Refereed

Zfat-Deficiency Results in a Loss of CD3ζ Phosphorylation with Dysregulation of ERK and Egr Activities Leading to Impaired Positive Selection
Masahiro Ogawa; Tadashi Okamura; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yoko Tanaka; Takeharu Ota; Kunihiro Hayakawa; Harumi Suzuki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
PLoS ONE, 03 Oct. 2013, 8(10):e76254, Refereed

ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response
Keiko Doi; Takahiro Fujimoto; Tadashi Okamura; Masahiro Ogawa; Yoko Tanaka; Yasumasa Mototani; Motohito Goto; Takeharu Ota; Hiroshi Matsuzaki; Masahide Kuroki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2012, 425(1):107 - 112, Refereed

Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model
Toshiyuki Tsunoda; Takeharu Ota; Takahiro Fujimoto; Keiko Doi; Yoko Tanaka; Yasuhiro Yoshida; Masahiro Ogawa; Hiroshi Matsuzaki; Masato Hamabashiri; Darren R. Tyson; Masahide Kuroki; Shingo Miyamoto; Senji Shirasawa
MOLECULAR CANCER, Jul. 2012, 11(1):46, Refereed

KRAS Up-regulates the Expression of miR-181a, miR-200c and miR-210 in a Three-dimensional-specific Manner in DLD-1 Colorectal Cancer Cells
Takeharu Ota; Keiko Doi; Takahiro Fujimoto; Yoko Tanaka; Masahiro Ogawa; Hiroshi Matsuzaki; Masahide Kuroki; Shingo Miyamoto; Senji Shirasawa; Toshiyuki Tsunoda
ANTICANCER RESEARCH, Jun. 2012, 32(6):2271 - 2275, Refereed

ALPK2 is Crucial for Luminal Apoptosis and DNA Repair-related Gene Expression in a Three-dimensional Colonic-crypt Model
Yasuhiro Yoshida; Toshiyuki Tsunoda; Keiko Doi; Takahiro Fujimoto; Yoko Tanaka; Takeharu Ota; Masahiro Ogawa; Hiroshi Matsuzaki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
ANTICANCER RESEARCH, Jun. 2012, 32(6):2301 - 2308, Refereed

Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells
Toshiyuki Tsunoda; Yasuo Takashima; Yasuhiro Yoshida; Keiko Doi; Yoko Tanaka; Takahiro Fujimoto; Takashi Machida; Takeharu Ota; Midori Koyanagi; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
ANTICANCER RESEARCH, Jul. 2011, 31(7):2453 - 2459, Refereed

KRAS-mediated Up-regulation of RRM2 Expression Is Essential for the Proliferation of Colorectal Cancer Cell Lines
Yasuhiro Yoshida; Toshiyuki Tsunoda; Keiko Doi; Yoko Tanaka; Takahiro Fujimoto; Takashi Machida; Takeharu Ota; Midori Koyanagi; Yasuo Takashima; Takehiko Sasazuki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
ANTICANCER RESEARCH, Jul. 2011, 31(7):2535 - 2539, Refereed

KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells
Takahiro Fujimoto; Takashi Machida; Yoko Tanaka; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Tadashi Okamura; Masahide Kuroki; Senji Shirasawa
Biochemical and Biophysical Research Communications, 08 Apr. 2011, 407(2):438 - 443, Refereed

ZFAT IS A CRITICAL MOLECULE FOR CELL SURVIVAL IN MOUSE EMBRYONIC FIBROBLASTS
Keiko Doi; Takahiro Fujimoto; Midori Koyanagi; Toshiyuki Tsunoda; Yoko Tanaka; Yasuhiro Yoshida; Yasuo Takashima; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
CELLULAR & MOLECULAR BIOLOGY LETTERS, Mar. 2011, 16(1):89 - 100, Refereed

Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands
Toshiyuki Tsunoda; Yasuo Takashima; Yoko Tanaka; Takahiro Fujimoto; Keiko Doi; Yumiko Hirose; Midori Koyanagi; Yasuhiro Yoshida; Tadashi Okamura; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2010, 107(32):14199 - 14204, Refereed

Three-dimensionally Specific Inhibition of DNA Repair-Related Genes by Activated KRAS in Colon Crypt Model
Toshiyuki Tsunoda; Yasuo Takashima; Takahiro Fujimoto; Midori Koyanagi; Yasuhiro Yoshida; Keiko Doi; Yoko Tanaka; Tanaka; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
NEOPLASIA, May 2010, 12(5):397 - U5, Refereed

Fiber arrangement of the intestinal smooth muscle layers in ammocoetes of Lampetra japonica
Y Tanaka; M Miyoshi; ET Chen
ZOOLOGY, 2002, 105(1):25 - 30, Refereed

A Scanning and Transmission Electron Microscopic Study of Contractile Trabecules in the Rat Spleen
Kazuo Kimura; Takami Fusano; Yoko Tanaka
Okajimas Folia Anatomica Japonica, Dec. 2001, 78(5):187 - 200, Refereed

Fenestrated Epithelium of the Pelvic Recess Wall on the Lateral Parenchymal Tissue in the Dog Kidney
Shotaro Nozaki; Takami Fusano; Yoko Tanaka; Masayuki Miyoshi
Okajimas Folia Anatomica Japonica, Dec. 2001, 78(5):201 - 210, Refereed

Japanese Association of Anatomists

脾洞内皮細胞血球通過機構の解明-内皮細胞ダイナミックスの解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
2004 - 2005