Menahydroquinone-4 may play a key role in regulating CCL5 expression induced by epidermal growth factor receptor inhibitors
Shotaro Goto; Shuichi Setoguchi; Daisuke Watase; Hirofumi Yamakawa; Ayano Yamada; Mitsuhisa Koga; Koichi Matsuo; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Scientific Reports, 13 Dec. 2023
Cationic Ester Prodrugs of Curcumin with N,N-dimethyl Amino Acid Promoieties Improved Poor Water Solubility and Intestinal Absorption
Mariko Hirano-Kusuda; Shuichi Setoguchi; Mitsuhisa Koga; Shotaro Goto; Ayano Yamada; Daisuke Watase; Nami Nagata-Akaho; Yoshiharu Karube; Kazuhisa Matsunaga; Jiro Takata
Pharmaceutical Research, 20 Apr. 2023
Delivery of the reduced form of vitamin K2(20) to NIH/3T3 cells partially protects against rotenone induced cell death
Erina Toki; Shotaro Goto; Shuichi Setoguchi; Kazuki Terada; Daisuke Watase; Hirofumi Yamakawa; Ayano Yamada; Mitsuhisa Koga; Kaori Kubota; Katsunori Iwasaki; Yoshiharu Karube; Kazuhisa Matsunaga; Jiro Takata
Scientific Reports, 18 Nov. 2022
Cationic N,N-Dimethylglycine Ester Prodrug of 2R-α-Tocotrienol Promotes Intestinal Absorption via Efficient Self-Micellization with Intrinsic Bile Acid Anion
Watase D; Setoguchi S; Nagata-Akaho N; Goto S; Yamakawa H; Yamada A; Koga M; Karube Y; Matsunaga K; Takata J
Molecules, 23 Apr. 2022, Refereed
Overcoming the Photochemical Problem of Vitamin K in Topical Application
intechopen, 03 Aug. 2021
Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K 2(20), on All-Trans Retinoic Acid-Resistant HL60 Cell Line
Hirofumi Yamakawa; Shuichi Setoguchi; Shotaro Goto; Daisuke Watase; Kazuki Terada; Nami Nagata-Akaho; Erina Toki; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Pharmaceutics, May 2021, Refereed
Ester derivatives of phyllohydroquinone effectively deliver the active form of vitamin K1 topically, owing to their non-photosensitivity
Shotaro Goto; Shuichi Setoguchi; Nami Nagata-Akaho; Kazuki Terada; Daisuke Watase; Hirofumi Yamakawa; Erina Toki; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Eur J Pharm Sci, 01 Dec. 2020, Refereed
Evaluation of photostability and phototoxicity of esterified derivatives of ubiquinol‐10 and their application as prodrugs of reduced coenzyme Q10 for topical administration
Setoguchi S; Nagata-Akaho N; Goto S; Yamakawa H; Watase D; Terada K; Koga M; Matsunaga K; Karube Y; Takata J
BioFactors, 06 Oct. 2020, Refereed
Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study.
Kazuki Terada; Ayumi Murata; Erina Toki; Shotaro Goto; Hirofumi Yamakawa; Shuichi Setoguchi; Daisuke Watase; Mitsuhisa Koga; Jiro Takata; Kazuhisa Matsunaga; Yoshiharu Karube
Molecules, Sep. 2020, Refereed
Prodrugs for Skin Delivery of Menahydroquinone-4, an Active Form of Vitamin K2(20), Could Overcome the Photoinstability and Phototoxicity of Vitamin K2(20)
Shotaro Goto; Shuichi Setoguchi; Hirofumi Yamakawa; Daisuke Watase; Kazuki Terada; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Int J Mol Sci, May 2019, Refereed
Antitumor Effects and Delivery Profiles of Menahydroquinone-4 Prodrugs with Ionic or Nonionic Promoiety to Hepatocellular Carcinoma Cells
Molecules, Jul. 2018, Refereed
EGFR阻害剤による皮膚障害の抑制を目指した光に安定な活性型ビタミンK誘導体の開発
後藤将太朗
日本ビタミン学会第74回大会, 26 Jun. 2022
活性型ビタミンK2誘導体はミトコンドリア阻害剤による細胞死を抑制する
土岐衣梨奈; 後藤将太朗; 瀨戸口修一; 寺田一樹; 渡瀬大輔; 山田彩乃; 古賀允久; 山川博文; 松永和久; 髙田二郎
日本ビタミン学会第74回大会, 26 Jun. 2022
皮膚細胞への酸化ストレス刺激に対する還元型CoQ誘導体の保護効果
Jun. 2021
Ubiquinol-10 エステル誘導体化による Ubiquinol-10 及び Ubiquinone-10 の光不安定性と光毒性の克服及び表皮角化細胞への送達性
Jun. 2020
Ubiquinol-10のイオン性エステル誘導体化による光安定性向上と水性製剤化検討
May 2020
Ubiquinol-10のイオン性エステル型プロドラッグ化によるUbiquinone-10光毒性の克服およびヒト表皮角化細胞を用いた送達性の評価
May 2020
皮膚適用を企図するフィロヒドロキノン（活性型ビタミンK1）エステル誘導体の光安定性と皮膚送達性の評価
May 2020
ロテノン誘発性ミトコンドリア機能障害に対するジプラシドンの効果
Mar. 2020
副腎皮質ステロイド剤によるマウス行動と神経成長因子の変化
Mar. 2020
Fluvoxamine recovered the nerve growth factor-induced neurite outgrowth inhibited by dexamethasone
Sep. 2019
キノン型ビタミン K と活性型ビタミン K プロドラッグの光照射に対する性質
Jun. 2019
光に安定な活性型ビタミンKプロドラッグは皮膚適用を可能にする
May 2019
