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Last Updated :2024/03/03

Ryo Ozuru

School of Medicine
Lecturer/Senior Assistant Professor

Researcher information

■ Degree
  • 博士(医学), 九州大学, 2017
■ Research Keyword
  • Leptospira
  • Leptospirosis
  • Adipose tissue
  • Machine learning
  • Enterohaemorrhagic E.coli (EHEC)
■ Field Of Study
  • Life sciences, Systems genomics, バイオインフォマティクス
  • Life sciences, Bacteriology

Career

■ Career
  • Oct. 2022 - Present
    Fukuoka University, Department of Microbiology and Immunology, Faculty of Medicine, 講師
  • Oct. 2015 - Present
    University of Occupational and Environmental Health, Japan, School of Medicine, 訪問研究員
  • Apr. 2021 - Sep. 2022
    Fukuoka University, Faculty of Medicine, 助教
  • Apr. 2015 - Mar. 2021
    Tottori University, Faculty of Medicine, 助教
■ Educational Background
  • Apr. 2013 - Mar. 2017
    Kyushu University, 医学系学府, 医学専攻
  • Apr. 2011 - Mar. 2013
    Kyushu University, システム生命科学府
  • Apr. 2007 - Mar. 2011
    Kyushu University, School of Medicine, 生命科学科

Research activity information

■ Paper
  • Insufficient anti-spike RBD IgA responses after triple vaccination with intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2
    Michinobu Yoshimura; Atsuhiko Sakamoto; Ryo Ozuru; Yusuke Kurihara; Ryota Itoh; Kazunari Ishii; Akinori Shimizu; Bin Chou; Yusuke Sechi; Aya Fujikane; Shigeki Nabeshima; Kenji Hiromatsu
    Heliyon, Jan. 2024, Refereed
  • The appearance of anti-spike RBD IgG4 responses after repetitive immunization with mRNA-based COVID-19 vaccines.
    Michinobu Yoshimura; Atsuhiko Sakamoto; Ryo Ozuru; Yusuke Kurihara; Ryota Itoh; Kazunari Ishii; Akinori Shimizu; Bin Chou; Shigeki Nabeshima; Kenji Hiromatsu
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 27 Nov. 2023, Refereed
  • Chlamydia pneumoniae Lung Infection in Mice Induces Fatty Acid-Binding Protein 4-Dependent White Adipose Tissue Pathology.
    Yusuke Kurihara; Nirwana Fitriani Walenna; Kazunari Ishii; Toshinori Soejima; Bin Chou; Michinobu Yoshimura; Ryo Ozuru; Akinori Shimizu; Ryota Itoh; Masato Furuhashi; Gökhan S Hotamisligil; Kenji Hiromatsu
    Journal of immunology (Baltimore, Md. : 1950), 15 Apr. 2023, Refereed
  • Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan
    Atsuhiko Sakamoto; Michinobu Yoshimura; Ryota Itoh; Ryo Ozuru; Kazunari Ishii; Yusuke Sechi; Shigeki Nabeshima; Kenji Hiromatsu
    Vaccines, May 2022, Refereed
  • Light dependent synthesis of a nucleotide second messenger controls the motility of a spirochete bacterium.
    Jun Xu; Nobuo Koizumi; Yusuke V Morimoto; Ryo Ozuru; Toshiyuki Masuzawa; Shuichi Nakamura
    Scientific reports, 26 Apr. 2022, Refereed
  • Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule
    Fumiko Obata; Ryo Ozuru; Takahiro Tsuji; Takashi Matsuba; Jun Fujii
    Toxins, 19 Jan. 2022, Refereed, Not invited
  • Investigation of Bacteria from Spoiled Bottled Salad Dressing Leading to Gas Explosion
    Fumiko Obata; Hiromi Murota; Satoshi Shibata; Ryo Ozuru; Jun Fujii
    Yonago Acta Medica, 2022
  • A machine learning model of microscopic agglutination test for diagnosis of leptospirosis
    Yuji Oyamada; Ryo Ozuru; Toshiyuki Masuzawa; Satoshi Miyahara; Yasuhiko Nikaido; Fumiko Obata; Mitsumasa Saito; Sharon Yvette Angelina M. Villanueva; Jun Fujii
    PLOS ONE, 16 Nov. 2021, Refereed, Not invited, Lead
  • 細菌検査を自動化する レプトスピラ症の顕微鏡下凝集試験(Microscopic Agglutination Test;MAT)を例に
    尾鶴 亮; 小山田 雄仁; 増澤 俊之; 宮原 敏; 二階堂 靖彦; 齋藤 光正; Villanueva Sharon Y.A.M.; 藤井 潤
    日本細菌学雑誌, Feb. 2021
  • 免疫不全マウスを用いた新たな劇症型溶血性レンサ球菌感染症マウスモデルの開発(Establishment of a new Streptococcal toxic shock syndrome model using immunocompromised mice)
    辻 高寛; 小幡 史子; 尾鶴 亮; 宮原 敏; 齋藤 光正; 藤井 潤
    日本細菌学雑誌, Feb. 2021
  • Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice.
    Ryo Ozuru; Shohei Wakao; Takahiro Tsuji; Naoya Ohara; Takashi Matsuba; Muhammad Y Amuran; Junko Isobe; Morio Iino; Naoki Nishida; Sari Matsumoto; Kimiharu Iwadate; Noriko Konishi; Kaori Yasuda; Kosuke Tashiro; Misato Hida; Arisato Yadoiwa; Shinsuke Kato; Eijiro Yamashita; Sohkichi Matsumoto; Yoichi Kurozawa; Mari Dezawa; Jun Fujii
    Molecular therapy : the journal of the American Society of Gene Therapy, 08 Jan. 2020, Refereed, Not invited, Lead
  • Inhibition of inflammatory-molecule synthesis in THP-1 cells stimulated with phorbol 12-myristate 13-acetate by brefelamide derivatives
    Gaowa Bai; Takashi Matsuba; Haruhisa Kikuchi; Haorile Chagan-Yasutan; Hirotoshi Motoda; Ryo Ozuru; Osamu Yamada; Yoshiteru Oshima; Toshio Hattori
    International Immunopharmacology, Oct. 2019, Refereed, Not invited
  • Inhibition of Osteopontin Synthesis in THP-1 Cells Stimulated with Phorbol 12-Myristate 13-Acetate by Brefelamide Derivatives
    Gaowa Bai; Takashi Matsuba; Haruhisa Kikuchi; Hirotoshi Motoda; Ryo Ozuru; Haorile Chagan-Yasutan; Osamu Yamada; Yoshiteru Oshima; Toshio Hattori
    Reprints, 03 Jan. 2019, Refereed, Not invited
  • Synthesis of a Cleaved Form of Osteopontin by THP-1 Cells and Its Alteration by Phorbol 12-Myristate 13-Acetate and BCG Infection
    Gaowa Bai; Hirotoshi Motoda; Ryo Ozuru; Haorile Chagan-Yasutan; Toshio Hattori; Takashi Matsuba
    International Journal of Molecular Sciences, 31 Jan. 2018, Refereed, Not invited, Lead
  • Adipose tissue is the first colonization site of Leptospira interrogans in subcutaneously infected hamsters
    Ryo Ozuru; Mitsumasa Saito; Takaaki Kanemaru; Satoshi Miyahara; Sharon Y. A. M. Villanueva; Gerald L. Murray; Ben Adler; Jun Fujii; Shin-ichi Yoshida
    PLOS ONE, Feb. 2017, Refereed, Not invited, Lead
  • The usefulness of semi-solid medium in the isolation of highly virulent Leptospira strains from wild rats in an urban area of Fukuoka, Japan
    Mitsumasa Saito; Sharon Y. A. M. Villanueva; Toshiyuki Masuzawa; Yusuke Haraguchi; Shuhei Ita; Satoshi Miyahara; Ryo Ozuru; Takayoshi Yamaguchi; Michinobu Yoshimura; Mami Ikejiri; Natsumi Aramaki; Muhammad Yunus Amran; Lisa Tenriesa Muslich; Ken-ichiro Iida; Yasutake Yanagihara; Nina G. Gloriani; Shin-ichi Yoshida
    MICROBIOLOGY AND IMMUNOLOGY, Jun. 2015, Refereed, Not invited
  • 半固形コルトフ培地を用いた福岡都心部の野生ラットからの病原性レプトスピラ分離と分離株の解析(The usefulness of semi-solid medium in the isolation of Leptospira strains from wild rats in Fukuoka)
    齋藤 光正; Villanueva Sharon Yvette Angelina; 増澤 俊幸; 宮原 敏; 尾鶴 亮; 山口 孝治; 吉村 芳修; 池尻 真美; 荒牧 夏美; 飯田 健一郎; 柳原 保武; 吉田 眞一
    日本細菌学雑誌, Feb. 2015
  • フィリピンで流行している五つのレプトスピラの血清型に対するワクチンの開発と評価(Development and evaluation of vaccines against 5 leptospiral serovars prevailing in the Philippines)
    Villanueva Sharon Yvette Angelina; 柳原 保武; 齋藤 光正; 瀬川 孝耶; 尾鶴 亮; 池尻 真美; Gloriani Nina; 吉田 眞一
    日本細菌学雑誌, Feb. 2015
  • Comparative Analysis of Leptospira Strains Isolated from Environmental Soil and Water in the Philippines and Japan
    Mitsumasa Saito; Sharon Y. A. M. Villanueva; Antara Chakraborty; Satoshi Miyahara; Takaya Segawa; Tatsuma Asoh; Ryo Ozuru; Nina G. Gloriani; Yasutake Yanagihara; Shin-ichi Yoshida
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Jan. 2013, Refereed, Not invited
■ MISC
  • 2016年、キュウリを原因とした腸管出血性大腸菌O157の集団感染
    尾鶴 亮; 立石 善隆; 小西 典子; 松本 壮吉; 松葉 隆司; 藤井 潤
    日本細菌学雑誌, Feb. 2018, Not refereed, Not invited
  • 2016年、キュウリを原因とした腸管出血性大腸菌O157の集団感染
    尾鶴 亮; 立石 善隆; 小西 典子; 松本 壮吉; 松葉 隆司; 藤井 潤
    日本細菌学雑誌, Feb. 2018, Not refereed, Not invited
  • 腸管出血性大腸菌感染マウスモデルおける再生医療(Muse細胞)を用いた急性脳症の治療効果(Effects of Muse cells on acute encephalopathy caused by Shiga toxin-producing E. coil infection in mice)
    尾鶴 亮; 若尾 昌平; 松葉 隆司; 磯部 順子; 木全 恵子; 綿引 正則; 出澤 真理; 藤井 潤
    日本細菌学雑誌, Feb. 2017, Not refereed, Not invited
■ Lectures, oral presentations, etc.
  • レプトスピラの病原性と菌体回転運動の関わり
    尾鶴亮
    第171回バイオメカニクス研究会, 16 Nov. 2018, Invited
■ Courses
  • Microbiology
    99 Apr. 2021, Fukuoka University
  • 基礎感染症学実習
    20 Apr. 2015, 鳥取大学
  • Basic Infectious Diseases
    20 Apr. 2016, Tottori University
■ Affiliated academic society
  • Jan. 2020, Present
    The Japanese Society for Bioinformatics
  • Feb. 2013, Present
    JAPANESE SOCIETY FOR BACTERIOLOGY
  • 日本レプトスピラ研究会
■ Research Themes
  • レプトスピラの脂肪組織定着機構を利用したレプトスピラ症新規バイオマーカーの創出
    若手研究
    鳥取大学
    01 Apr. 2021 - 31 Mar. 2024
  • Elucidation of the molecular mechanism by which Leptospira colonizes on host adipose tissue blood vessels
    Grant-in-Aid for Early-Career Scientists
    Tottori University
    Apr. 2018 - Mar. 2021