Oct. 2006
American Society of Hypertension, New Investigator Travel Award -Japanese Fellows (Supported by Pfizer)
Interferon-Gamma-mediated pathway-new target for prevention of vascular remodeling after vascular injury-
Misthusa Koga

Menahydroquinone-4 may play a key role in regulating CCL5 expression induced by epidermal growth factor receptor inhibitors
Shotaro Goto; Shuichi Setoguchi; Daisuke Watase; Hirofumi Yamakawa; Ayano Yamada; Mitsuhisa Koga; Koichi Matsuo; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Scientific Reports, 13 Dec. 2023

Association of T cell infiltration and morphological change of thymus gland with the aggravation of pulmonary emphysema in testosterone deficiency.
Kentaro Aono; Junichi Matsumoto; Taichi Matsumoto; Mitsuhisa Koga; Keisuke Migita; Koji Tominaga; Shinsuke Nakagawa; Atsushi Yamauchi
Biochemistry and biophysics reports, Jul. 2023

Cationic Ester Prodrugs of Curcumin with N,N-dimethyl Amino Acid Promoieties Improved Poor Water Solubility and Intestinal Absorption
Mariko Hirano-Kusuda; Shuichi Setoguchi; Mitsuhisa Koga; Shotaro Goto; Ayano Yamada; Daisuke Watase; Nami Nagata-Akaho; Yoshiharu Karube; Kazuhisa Matsunaga; Jiro Takata
Pharmaceutical Research, 20 Apr. 2023

Delivery of the reduced form of vitamin K2(20) to NIH/3T3 cells partially protects against rotenone induced cell death
Erina Toki; Shotaro Goto; Shuichi Setoguchi; Kazuki Terada; Daisuke Watase; Hirofumi Yamakawa; Ayano Yamada; Mitsuhisa Koga; Kaori Kubota; Katsunori Iwasaki; Yoshiharu Karube; Kazuhisa Matsunaga; Jiro Takata
Scientific Reports, 18 Nov. 2022

Moxifloxacin induces aortic aneurysm and dissection by increasing osteopontin in mice.
Koshun Inada; Mitsuhisa Koga; Ayano Yamada; Shinya Dohgu; Atsushi Yamauchi
Biochemical and biophysical research communications, 12 Nov. 2022

Cationic N,N-Dimethylglycine Ester Prodrug of 2R-α-Tocotrienol Promotes Intestinal Absorption via Efficient Self-Micellization with Intrinsic Bile Acid Anion
Daisuke Watase; Shuichi Setoguchi; Nami Nagata-Akaho; Shotaro Goto; Hirofumi Yamakawa; Ayano Yamada; Mitsuhisa Koga; Yoshiharu Karube; Kazuhisa Matsunaga; Jiro Takata
Molecules, 23 Apr. 2022

Testosterone deficiency promotes the development of pulmonary emphysema in orchiectomized mice exposed to elastase.
Kentaro Aono; Junichi Matsumoto; Shinsuke Nakagawa; Taichi Matsumoto; Mitsuhisa Koga; Keisuke Migita; Koji Tominaga; Yuna Sakai; Atsushi Yamauchi
Biochemical and biophysical research communications, 18 Jun. 2021

Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K2(20), on All-Trans Retinoic Acid-Resistant HL60 Cell Line.
Hirofumi Yamakawa; Shuichi Setoguchi; Shotaro Goto; Daisuke Watase; Kazuki Terada; Nami Nagata-Akaho; Erina Toki; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Pharmaceutics, 20 May 2021

Evaluation of photostability and phototoxicity of esterified derivatives of ubiquinol-10 and their application as prodrugs of reduced coenzyme Q10 for topical administration.
Shuichi Setoguchi; Nami Nagata-Akaho; Shotaro Goto; Hirofumi Yamakawa; Daisuke Watase; Kazuki Terada; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
BioFactors (Oxford, England), 06 Oct. 2020

動脈硬化症とCOPDにおける禁煙補助薬バレニクリンの効果
Medical Science Digest, Oct. 2020
Lead

Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study.
Kazuki Terada; Ayumi Murata; Erina Toki; Shotaro Goto; Hirofumi Yamakawa; Shuichi Setoguchi; Daisuke Watase; Mitsuhisa Koga; Jiro Takata; Kazuhisa Matsunaga; Yoshiharu Karube
Molecules (Basel, Switzerland), 14 Sep. 2020

Ester derivatives of phyllohydroquinone effectively deliver the active form of vitamin K1 topically, owing to their non-photosensitivity.
Shotaro Goto; Shuichi Setoguchi; Nami Nagata-Akaho; Kazuki Terada; Daisuke Watase; Hirofumi Yamakawa; Erina Toki; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 18 Aug. 2020

Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages.
Mitsuhisa Koga; Yuki Kanaoka; Koshun Inada; Sai Omine; Yasufumi Kataoka; Atsushi Yamauchi
Journal of pharmacological sciences, Jun. 2020

Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions.
Shuichi Setoguchi; Ryoji Hidaka; Nami Nagata-Akaho; Daisuke Watase; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Molecules (Basel, Switzerland), 27 Jan. 2020

Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression.
Mitsuhisa Koga; Yuki Kanaoka; Mana Okamoto; Yuki Nakao; Koshun Inada; Saki Takayama; Yasufumi Kataoka; Atsushi Yamauchi
Journal of pharmacological sciences, Jan. 2020

Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.
Akio Nakashima; Atsushi Yamauchi; Junichi Matsumoto; Shinya Dohgu; Fuyuko Takata; Mitsuhisa Koga; Jiro Fukae; Yoshio Tsuboi; Yasufumi Kataoka
Behavioural pharmacology, Feb. 2019

Varenicline is a smoking cessation drug that blocks alveolar expansion in mice intratracheally administrated porcine pancreatic elastase.
Mitsuhisa Koga; Yuki Kanaoka; Tetsushi Tashiro; Nagisa Hashidume; Yasufumi Kataoka; Atsushi Yamauchi
Journal of pharmacological sciences, Jun. 2018

Varenicline promotes endothelial cell migration by lowering vascular endothelial-cadherin levels via the activated α7 nicotinic acetylcholine receptor-mitogen activated protein kinase axis.
Mitsuhisa Koga; Yuki Kanaoka; Keita Sugiyama; Kaoru Ohishi; Yuka Ejima; Mami Hisanaga; Yasufumi Kataoka; Atsushi Yamauchi
Toxicology, 01 Sep. 2017

Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood-brain barrier dysfunction in vitro.
Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Ikuya Kimura; Mariko Koga; Keiko Nakamoto; Atsushi Yamauchi; Yasufumi Kataoka
NEUROSCIENCE, May 2017, Refereed

Varenicline enhances oxidized LDL uptake by increasing expression of LOX-1 and CD36 scavenger receptors through α(7) nAChR in macrophages.
Yuki Kanaoka; Mitsuhisa Koga; Keita Sugiyama; Kaoru Ohishi; Yasufumi Kataoka; Atsushi Yamauchi
Toxicology, 01 Apr. 2017

COPDと免疫系α７ nAChR
アレルギーの臨床, Apr. 2017

Tissue Remodeling in Vascular Wall in Kawasaki Disease-Related Vasculitis Model Mice
Yukako Yoshikane; Mitsuhisa Koga; Tamaki Cho; Kyoko Imanaka-Yoshida; Yumi Yamamoto; Junichi Hashimoto; Hiroki Aoki; Koichi Yoshimura; Shinichi Hirose
2016

Elevated permeability of the blood-brain barrier in mice intratracheally administered porcine pancreatic elastase.
Fuyuko Takata; Koji Tominaga; Mitsuhisa Koga; Shinya Dohgu; Koujiro Futagami; Atsushi Yamauchi; Yasufumi Kataoka
Journal of pharmacological sciences, Sep. 2015

JNK is critical for the development of Candida albicans-induced vascular lesions in a mouse model of Kawasaki disease
Yukako Yoshikane; Mitsuhisa Koga; Kyoko Imanaka-Yoshida; Tamaki Cho; Yumi Yamamoto; Toshimichi Yoshida; Junichi Hashimoto; Shinichi Hirose; Koichi Yoshimura
Cardiovascular Pathology, 01 Jan. 2015

Varenicline aggravates plaque formation through α7 nicotinic acetylcholine receptors in ApoE KO mice.
Mitsuhisa Koga; Yuki Kanaoka; Yuma Ohkido; Naoka Kubo; Kaoru Ohishi; Keita Sugiyama; Atsushi Yamauchi; Yasufumi Kataoka
Biochemical and biophysical research communications, 12 Dec. 2014

BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances uptake of oxidized low density lipoprotein into peritoneal macrophages.
Mitsuhisa Koga; Atsushi Yamauchi; Yuki Kanaoka; Ryusuke Jige; Anna Tsukamoto; Nao Teshima; Tsuyoshi Nishioku; Yasufumi Kataoka
Journal of inflammation (London, England), 09 Oct. 2013, Refereed

The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice.
Mitsuhisa Koga; Niels Engberding; Anna E Dikalova; Kyung Hwa Chang; Bonnie Seidel-Rogol; James S Long; Bernard Lassègue; Hanjoong Jo; Kathy K Griendling
American journal of physiology. Heart and circulatory physiology, 01 Sep. 2013, Refereed

Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats.
Suguru Yasuoka; Hisashi Kai; Hidemi Kajimoto; Hiroshi Kudo; Narimasa Takayama; Takahiro Anegawa; Mitsuhisa Koga; Takanobu Miyamoto; Hiroharu Mifune; Masayoshi Kage; Yoshitaka Hirooka; Tsutomu Imaizumi
Circulation journal : official journal of the Japanese Circulation Society, 2013, Refereed

Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis.
Tsuyoshi Nishioku; Shinya Dohgu; Mitsuhisa Koga; Takashi Machida; Takuya Watanabe; Teppei Miura; Kousuke Tsumagari; Mariko Terasawa; Atsushi Yamauchi; Yasufumi Kataoka
Journal of inflammation (London, England), 20 Nov. 2012, Refereed

A role for hypothalamic AMP-activated protein kinase in the mediation of hyperphagia and weight gain induced by chronic treatment with olanzapine in female rats.
Ei Sejima; Atsushi Yamauchi; Tsuyoshi Nishioku; Mitsuhisa Koga; Kengo Nakagama; Shinya Dohgu; Kojiro Futagami; Yasufumi Kataoka
Cellular and molecular neurobiology, Oct. 2011, Refereed

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro.
Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Hiroyuki Takahashi; Takashi Machida; Tomoya Wakigawa; Eriko Harada; Haruki Miyaji; Mitsuhisa Koga; Tsuyoshi Nishioku; Atsushi Yamauchi; Yasufumi Kataoka
Journal of neuroinflammation, 26 Aug. 2011, Refereed

Enhanced cardiac inflammation and fibrosis in ovariectomized hypertensive rats: a possible mechanism of diastolic dysfunction in postmenopausal women.
Takahiro Mori; Hisashi Kai; Hidemi Kajimoto; Mitsuhisa Koga; Hiroshi Kudo; Narimasa Takayama; Suguru Yasuoka; Takahiro Anegawa; Mamiko Kai; Tsutomu Imaizumi
Hypertension research : official journal of the Japanese Society of Hypertension, Apr. 2011, Refereed

Reduction and activation of circulating dendritic cells in patients with decompensated heart failure.
Yusuke Sugi; Hideo Yasukawa; Hisashi Kai; Daisuke Fukui; Nobuyoshi Futamata; Kazuhisa Mawatari; Toyoharu Oba; Nobutaka Nagata; Sachiko Kyougoku; Mitsuhisa Koga; Tsutomu Imaizumi
International journal of cardiology, 03 Mar. 2011, Refereed

Simvastatin prevents large blood pressure variability induced aggravation of cardiac hypertrophy in hypertensive rats by inhibiting RhoA/Ras-ERK pathways.
Narimasa Takayama; Hisashi Kai; Hiroshi Kudo; Suguru Yasuoka; Takahiro Mori; Takahiro Anegawa; Mitsuhisa Koga; Hidemi Kajimoto; Yoshitaka Hirooka; Tsutomu Imaizumi
Hypertension research : official journal of the Japanese Society of Hypertension, Mar. 2011, Refereed

Exaggerated blood pressure variability superimposed on hypertension aggravates cardiac remodeling in rats via angiotensin II system-mediated chronic inflammation.
Hiroshi Kudo; Hisashi Kai; Hidemi Kajimoto; Mitsuhisa Koga; Narimasa Takayama; Takahiro Mori; Ayami Ikeda; Suguru Yasuoka; Takahiro Anegawa; Hiroharu Mifune; Seiya Kato; Yoshitaka Hirooka; Tsutomu Imaizumi
Hypertension (Dallas, Tex. : 1979), Oct. 2009, Refereed

Insulin-like growth factor-1 receptor expression masks the antiinflammatory and glucose uptake capacity of insulin in vascular smooth muscle cells.
Niels Engberding; Alejandra San Martín; Abel Martin-Garrido; Mitsuhisa Koga; Lily Pounkova; Erin Lyons; Bernard Lassègue; Kathy K Griendling
Arteriosclerosis, thrombosis, and vascular biology, Mar. 2009, Refereed

Mutant MCP-1 therapy inhibits tumor angiogenesis and growth of malignant melanoma in mice.
Mitsuhisa Koga; Hisashi Kai; Kimiyasu Egami; Toyoaki Murohara; Ayami Ikeda; Suguru Yasuoka; Kensuke Egashira; Toyojiro Matsuishi; Mamiko Kai; Yasufumi Kataoka; Michihiko Kuwano; Tsutomu Imaizumi
Biochemical and biophysical research communications, 11 Jan. 2008, Refereed

Inhibition of progression and stabilization of plaques by postnatal interferon-gamma function blocking in ApoE-knockout mice.
Mitsuhisa Koga; Hisashi Kai; Hideo Yasukawa; Tomoka Yamamoto; Yumiko Kawai; Seiya Kato; Ken Kusaba; Mamiko Kai; Kensuke Egashira; Yasufumi Kataoka; Tsutomu Imaizumi
Circulation research, 17 Aug. 2007, Refereed

Inhibition of intrinsic interferon-gamma function prevents neointima formation after balloon injury.
Ken Kusaba; Hisashi Kai; Mitsuhisa Koga; Narimasa Takayama; Ayami Ikeda; Hideo Yasukawa; Yukihiko Seki; Kensuke Egashira; Tsutomu Imaizumi
Hypertension (Dallas, Tex. : 1979), Apr. 2007, Refereed

Postnatal blocking of interferon-gamma function prevented atherosclerotic plaque formation in apolipoprotein E-knockout mice.
Mitsuhisa Koga; Hisashi Kai; Hideo Yasukawa; Seiya Kato; Tomoka Yamamoto; Yumiko Kawai; Ken Kusaba; Yukihiko Seki; Mamiko Kai; Kensuke Egashira; Yasufumi Kataoka; Tsutomu Imaizumi
Hypertension research : official journal of the Japanese Society of Hypertension, Mar. 2007, Refereed

高血圧患者における非薬物治療の重要性
古賀 允久; 甲斐 久史; 川井 友美子; 甲斐 麻美子; 片岡 泰文; 今泉 勉
日本病院薬剤師会雑誌, Aug. 2006

Pressure-independent effects of angiotensin II on hypertensive myocardial fibrosis.
Keisuke Tokuda; Hisashi Kai; Fumitaka Kuwahara; Hideo Yasukawa; Nobuhiro Tahara; Hiroshi Kudo; Kiyoko Takemiya; Mitsuhisa Koga; Tomoka Yamamoto; Tsutomu Imaizumi
Hypertension (Dallas, Tex. : 1979), Feb. 2004, Refereed

Rho-kinase inhibition reduces neointima formation after vascular injury by enhancing Bax expression and apoptosis.
Rei Shibata; Hisashi Kai; Yukihiko Seki; Ken Kusaba; Kiyoko Takemiya; Mitsuhisa Koga; Ali Jalalidin; Keisuke Tokuda; Nobuhiro Tahara; Hiroshi Niiyama; Tsuyoshi Nagata; Fumitaka Kuwahara; Tsutomu Imaizumi
Journal of cardiovascular pharmacology, Dec. 2003

Oncostatin M, an interleukin-6 family cytokine, upregulates matrix metalloproteinase-9 through the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cultured smooth muscle cells.
Tsuyoshi Nagata; Hisashi Kai; Rei Shibata; Mitsuhisa Koga; Akihiko Yoshimura; Tsutomu Imaizumi
Arteriosclerosis, thrombosis, and vascular biology, 01 Apr. 2003, Refereed

Roles of intercellular adhesion molecule-1 in hypertensive cardiac remodeling.
Fumitaka Kuwahara; Hisashi Kai; Keisuke Tokuda; Hiroshi Niiyama; Nobuhiro Tahara; Ken Kusaba; Kiyoko Takemiya; Ali Jalalidin; Mitsuhisa Koga; Tsuyoshi Nagata; Rei Shibata; Tsutomu Imaizumi
Hypertension (Dallas, Tex. : 1979), Mar. 2003

Ubiquinol-10のイオン性エステル型プロドラッグ化によるUbiquinone-10光毒性の克服およびヒト表皮角化細胞を用いた送達性の評価
牛島 望; 瀬戸口 修一; 後藤 将太朗; 山川 博文; 渡瀬 大輔; 古賀 允久; 高田 二郎
日本薬剤学会年会講演要旨集, May 2020

Ubiquinol-10のイオン性エステル誘導体化による光安定性向上と水性製剤化検討
境 理那; 瀬戸口 修一; 後藤 将太朗; 山川 博文; 渡瀬 大輔; 古賀 允久; 高田 二郎
日本薬剤学会年会講演要旨集, May 2020

皮膚適用を企図するフィロヒドロキノン(活性型ビタミンK1)エステル誘導体の光安定性と皮膚送達性の評価
後藤 将太朗; 瀬戸口 修一; 渡瀬 大輔; 寺田 一樹; 山川 博文; 土岐 衣梨奈; 古賀 允久; 松永 和久; 加留部 善晴; 高田 二郎
日本薬剤学会年会講演要旨集, May 2020

Ubiquinol-10エステル誘導体化によるUbiquinol-10及びUbiquinone-10の光不安定性と光毒性の克服及び表皮角化細胞への送達性
山川 博文; 後藤 将太朗; 瀬戸口 修一; 渡瀬 大輔; 寺田 一樹; 土岐 衣梨奈; 古賀 允久; 松永 和久; 加留部 善晴; 高田 二郎
ビタミン, Apr. 2020

COPDモデルマウスにおけるリポキシンA4に対するエストロゲンの影響
冨永 宏治; 青野 健太郎; 松本 純一; 古賀 允久; 山内 淳史; 江川 孝; 片岡 泰文
日本薬学会年会要旨集, Mar. 2020

ロテノン誘発性ミトコンドリア機能障害に対するジプラシドンの効果
村田 亜侑美; 土岐 衣梨奈; 寺田 一樹; 後藤 将太朗; 松永 和久; 山川 博文; 渡瀬 大輔; 瀬戸口 修一; 古賀 允久; 高田 二郎; 加留部 善晴
日本薬学会年会要旨集, Mar. 2020

「喘息とCOPDのオーバーラップ症候群(ACOS)-病態と治療-」に寄せる COPDと免疫系α7 nAChR
古賀 允久; 山内 敦史; 片岡 泰文
アレルギーの臨床, Apr. 2017

バレニクリンはマクロファージにおける酸化LDLによる泡沫化を促進する
金岡 祐輝; 古賀 允久; 山内 淳史; 片岡 泰文
日本薬学会年会要旨集, Mar. 2016

バレニクリンによるα7nAChRを介する動脈硬化巣形成の増悪作用
金岡 祐輝; 古賀 允久; 大石 かおる; 杉山 慶太; 江島 優佳; 久永 真未; 山内 淳史; 片岡 泰文
日本薬学会年会要旨集, Mar. 2015

川崎病冠動脈瘤形成予防薬開発 JNK阻害薬 汎血管炎モデルマウスを用いた検討
吉兼 由佳子; 橋本 淳一; 古賀 允久; 長 環; 吉村 耕一; 今中 恭子; 廣瀬 伸一
日本小児科学会雑誌, Feb. 2014

C.-jun N-terminal Kinase is a Novel Therapeutic Target for Controlling the Development of Kawasaki Disease-related Arterial Aneurysm
Yukako Yoshikane; Mitsuhisa Koga; Tamaki Cho; Kyoko Imanaka-Yoshida; Junichi Hashimoto; Hiroki Aoki; Koichi Yoshimura; Shinichi Hirose
CIRCULATION, Nov. 2013

JNK阻害薬による動脈瘤形成の抑制 川崎病類似汎血管炎モデルマウスを用いた検討
吉兼 由佳子; 吉村 耕一; 今中 恭子; 長 環; 古賀 允久; 山本 由美子; 青木 浩樹; 橋本 淳一; 上田 誠; 廣瀬 伸一
日本小児循環器学会雑誌, Jun. 2013

糖尿病併発による動脈硬化巣の形成過程におけるBMP4の役割
古賀 允久; 金岡 祐輝; 地下 隆介; 西奥 剛; 山内 淳史; 片岡 泰文
日本薬理学雑誌, Mar. 2013

川崎病類似汎血管炎モデルマウス病理組織の経時的変化 テネイシンCとの関連
吉兼 由佳子; 橋本 淳一; 上田 誠; 長 環; 古賀 允久; 吉村 耕一; 山本 由美子; 今中 恭子; 廣瀬 伸一
日本小児科学会雑誌, Feb. 2013

アポリポタンパクE欠損マウスの動脈硬化に対するインターフェロンγの機能阻害効果
古賀 允久
福岡大学薬学集報, Jan. 2008

動脈硬化プラークの進展・不安定化におけるインターフェロンγの役割
甲斐 久史; 古賀 允久; 今泉 勉
日本動脈硬化学会総会プログラム・抄録集, Jun. 2007

Exaggerated blood pressure variability aggravates hypertensive cardiac remodeling through the angiotensin II-mediated inflammation
Hiroshi Kudo; Hisashi Kai; Narimasa Takayama; Takahiro Mori; Yusuke Sugi; Daisuke Fukui; Kiyoko Takemiya; Ayami Ikeda; Masayosi Futamata; Hideo Yasukawa; Mitsuhisa Koga; Yumiko Kawai; Yoshitaka Hirooka; Tsutomu Imaizumi
JOURNAL OF HYPERTENSION, Dec. 2006

Exaggerated blood pressure variability aggravates hypertensive cardiac remodeling through the angiotensin II-mediated inflammation
Hiroshi Kudo; Hisashi Kai; Narimasa Takayama; Takahiro Mori; Yusuke Sugi; Daisuke Fukui; Kiyoko Takemiya; Ayami Ikeda; Masayoshi Futamata; Hideo Yasukawa; Nobuhiro Tahara; Mitsuhisa Koga; Yumiko Kawai; Yoshitaka Hirooka; Tsutomu Imaizumi
HYPERTENSION, Oct. 2006

可溶型インターフェロンγ療法はApoEノックアウトマウスの動脈硬化巣を退縮させ,安定化させる
古賀 允久; 甲斐 久史; 山本 知佳; 片岡 泰文; 今泉 勉
日本薬理学雑誌, Mar. 2005

高血圧性肥大心における炎症機転と心血管リモデリング 心筋線維化抑制による拡張能障害治療の可能性
甲斐 久史; 古賀 允久; 今泉 勉
日本動脈硬化学会総会プログラム・抄録集, Jul. 2004

新規ビタミンEエステル型プロドラッグによるNASHに関連した心血管リスク抑制効果
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2021 - 31 Mar. 2024

飲酒量低減薬ナルメフェンによる動脈硬化症の発症機序
日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
福岡大学
01 Apr. 2020 - 31 Mar. 2023

頭部外傷後の遅延性てんかん発症をBMP4/PDGFRβ活性化ペリサイトが牽引する
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2018 - 31 Mar. 2021

高尿酸血症病態における禁煙補助薬バレニクリンによる動脈硬化進展の加速・増悪機序
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2018 - 31 Mar. 2021

慢性閉塞性肺疾患における禁煙補助薬バレニクリンの肺保護作用と発現機序
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2017 - 31 Mar. 2020

SAA/LXA4バランスにより制御される慢性閉塞性肺疾患のエストロゲンによる変容
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2017 - 31 Mar. 2020

川崎病急性期新治療薬「シアル化Fc製剤」の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2016 - 31 Mar. 2019

慢性閉塞性肺疾患における禁煙補助薬バレニクリンによる心血管イベント発症機序
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B)
Fukuoka University
01 Apr. 2015 - 31 Mar. 2017

シクロフィリンA-CD147シグナルを基盤とした脳血管性認知症の白質病変形成機構
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
01 Apr. 2013 - 31 Mar. 2016

禁煙補助薬バレニクリンによるα７ニコチン受容体を介した心血管イベント発症機序
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B)
Fukuoka University
01 Apr. 2013 - 31 Mar. 2015

ＪＮＫ抑制による川崎病冠動脈瘤に対する退縮治癒療法の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
Fukuoka University
2011 - 2013

性差からみた高血圧心における臓器障害の機序の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
Kurume University
2007 - 2008