30 Jan. 2010
福岡県医学会, 第2回福岡県医学会賞 奨励賞
全身性中性脂肪蓄積症における脂肪滴関連リパーゼAdipose triglyceride lipase遺伝子異常の発見とその機能解析

A novel homozygous missense mutation in PNPLA2 in a patient manifesting primary triglyceride deposit cardiomyovasculopathy
Yasuhiro Hara; Yoshihiko Ikeda; Hayato Kimura; Shinsaku Shimamoto; Mao Ishikawa; Kunihisa Kobayashi; Hironori Nagasaka; Hisashi Shimoyama; Ken-ichi Hirano
Molecular Genetics and Metabolism Reports, Feb. 2023, Refereed

A simplified prediction model for end-stage kidney disease in patients with diabetes.
Toyoshi Inoguchi; Tasuku Okui; Chinatsu Nojiri; Erina Eto; Nao Hasuzawa; Yukihiro Inoguchi; Kentaro Ochi; Yuichi Takashi; Fujiyo Hiyama; Daisuke Nishida; Fumio Umeda; Teruaki Yamauchi; Daiji Kawanami; Kunihisa Kobayashi; Masatoshi Nomura; Naoki Nakashima
Scientific reports, 21 Jul. 2022, Refereed

Adrenal Hemorrhage in a Cortisol-Secreting Adenoma Caused by Antiphospholipid Syndrome Revealed by Clinical and Pathological Investigations: A Case Report
Ochi K; Abe I; Yamazaki Y; Nagata M; Senda Y; Takeshita K; Koga M; Yamao Y; Shigeoka T; Kudo T; Fukuhara Y; Miyajima S; Taira H; Haraoka S; Ishii T; Takashi Y; Lam AK; Sasano H; Kobayashi K
Front. Endocrinol., Feb. 2022, Refereed

Association of serum total bilirubin levels with progressive renal decline and end-stage kidney disease: 10-year observational cohort study in Japanese patients with diabetes.
Erina Eto; Yasutaka Maeda; Noriyuki Sonoda; Naoki Nakashima; Kunihisa Kobayashi; Ryoichi Takayanagi; Yoshihiro Ogawa; Toyoshi Inoguchi
PloS one, 2022, Refereed

高LDLコレステロール血症
越智健太郎; 小林邦久
臨床と研究, 01 Jan. 2022

【インタベ医に知って欲しい新たな冠動脈病変惹起性脂質代謝異常-中性脂肪蓄積心筋血管症(TGCV)-】TGCV診断基準2020
小林 邦久
Coronary Intervention, Sep. 2021

生活習慣病の予防と治療 糖尿病
小林邦久
臨床と研究, Apr. 2021

Reduction in parathyroid adenomas by cinacalcet therapy in patients with primary hyperparathyroidism.
Midori Minezaki; Yuichi Takashi; Kentaro Ochi; Ryo Mitsuoka; Yuka Yamao; Tadachika Kudo; Daiji Kawanami; Kunihisa Kobayashi; Ichiro Abe
Journal of bone and mineral metabolism, 06 Jan. 2021, Refereed

Outside-in signaling by femoral cuff injury induces a distinct vascular lesion in adipose triglyceride lipase knockout mice.
Hirotsugu Noguchi; Sohsuke Yamada; Ken-Ichi Hirano; Satoshi Yamaguchi; Akira Suzuki; Xin Guo; Nobuhiro Zaima; Ming Li; Kunihisa Kobayashi; Yoshihiko Ikeda; Toshiyuki Nakayama; Yasuyuki Sasaguri
Histology and histopathology, Jan. 2021, Refereed

Characteristics and clinical outcomes in pituitary incidentalomas and non-incidental pituitary tumors treated with endoscopic transsphenoidal surgery.
Yusuke Morinaga; Ichiro Abe; Kouhei Nii; Hayatsura Hanada; Yusuke Takemura; Yuichi Takashi; Kimiya Sakamoto; Ritsurou Inoue; Takafumi Mitsutake; Kunihisa Kobayashi; Toshio Higashi
Medicine, 30 Oct. 2020, Refereed

Comprehensive Efficacy of the Dipeptidyl Peptidase 4 Inhibitor Alogliptin in Practical Clinical Settings: A Prospective Multi-Center Interventional Observational Study.
Yosuke Takamiya; Kunihisa Kobayashi; Tadachika Kudo; Tetsu Okuda; Keisuke Okamura; Kazuyuki Shirai; Hidenori Urata
Journal of clinical medicine research, Jul. 2020, Refereed

甲状腺穿刺吸引細胞診後に生じた甲状腺腫大：救急外来における超音波検査が迅速な鑑別診断に有用であった前頸部腫脹の1例
池田 悠悟; 阿部 一朗; 小林 邦久
超音波医学, 01 Jan. 2020, Refereed

シックデイ対応マニュアルの作成およびそれを用いた服薬指導の重要性
中島章雄; 松尾宏一; 宮崎元康; 内山将伸; 鵜木亜矢子; 後藤美和; 高木聡子; 三﨑桃子; 福江悠香; 中島千絵; 小林邦久; 今給黎修
薬理と治療, 01 Jan. 2020, Refereed

Multicenter prospective observational study of teneligliptin, a selective dipeptidyl peptidase-4 inhibitor, in patients with poorly controlled type 2 diabetes: Focus on glycemic control, hypotensive effect, and safety Chikushi Anti-Diabetes Mellitus Trial-Teneligliptin (CHAT-T).
Yosuke Takamiya; Keisuke Okamura; Kazuyuki Shirai; Tetsu Okuda; Kunihisa Kobayashi; Hidenori Urata
Clinical and experimental hypertension (New York, N.Y. : 1993), 2020

The Diagnostic Criteria 2020 for Triglyceride Deposit Cardiomyovasculopathy
Kunihisa Kobayashi; Yasuhiko Sakata; Hideyuki Miyauchi; Yoshihiko Ikeda; Yasuyuki Nagasawa; Kenichi Nakajima; Kazunori Shimada; Junji Kozawa; Hiroyuki Hao; Tetsuya Amano; Hiroshi Yoshida; Tohru Inaba; Chikako Hashimoto; Ken-ichi Hirano; for the Japan TGCV; Study Group
Annals of Nuclear Cardiology, 2020

A historical case of primary triglyceride deposit cardiomyovasculopathy.
Michio Tanaka; Yoshihiko Ikeda; Ming Li; Nobuhiro Zaima; Yutaka Kawahara; Koji Watanabe; Tohru Inaba; Kunihisa Kobayashi; Hirotsugu Noguchi; Sohsuke Yamada; Hiroyuki Hao; Ken-Ichi Hirano
Pathology international, Jan. 2020, Refereed

Effect of denosumab, a human monoclonal antibody of receptor activator of nuclear factor kappa-B ligand (RANKL), upon glycemic and metabolic parameters: Effect of denosumab on glycemic parameters.
Ichiro Abe; Kentaro Ochi; Yuichi Takashi; Yuka Yamao; Hanako Ohishi; Hideyuki Fujii; Midori Minezaki; Kaoru Sugimoto; Tadachika Kudo; Makiko Abe; Yasushi Ohnishi; Shigeaki Mukoubara; Kunihisa Kobayashi
Medicine, Nov. 2019, Refereed

Clinical investigation of pituitary incidentalomas: A two-center study.
Kota Ishii; Ichiro Abe; Wataru Kameda; Kaoru Sugimoto; Yusuke Morinaga; Miiko Ito; Yuichi Takashi; Makiko Abe; Yurika Hada; Kaoru Takase; Hideyuki Fujii; Hanako Ohishi; Kentaro Ochi; Yuka Yamao; Midori Minezaki; Tadachika Kudo; Toshio Higashi; Yukihiko Sonoda; Kenichi Ishizawa; Kunihisa Kobayashi
Intractable & rare diseases research, Nov. 2019, Refereed

全身疾患と排便障害―内分泌疾患・糖尿病
小林邦久
臨床と研究, 31 Aug. 2019

DPP-4阻害薬 ～The First 10 Years～
野見山崇; 小林邦久; 柳瀬敏彦; 浦田秀則
日本体質医学会雑誌, 30 Jun. 2019, Refereed

Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder.
Ming Li; Ken-Ichi Hirano; Yoshihiko Ikeda; Masahiro Higashi; Chikako Hashimoto; Bo Zhang; Junji Kozawa; Koichiro Sugimura; Hideyuki Miyauchi; Akira Suzuki; Yasuhiro Hara; Atsuko Takagi; Yasuyuki Ikeda; Kazuhiro Kobayashi; Yoshiaki Futsukaichi; Nobuhiro Zaima; Satoshi Yamaguchi; Rojeet Shrestha; Hiroshi Nakamura; Katsuhiro Kawaguchi; Eiryu Sai; Shu-Ping Hui; Yusuke Nakano; Akinori Sawamura; Tohru Inaba; Yasuhiko Sakata; Yoko Yasui; Yasuyuki Nagasawa; Shintaro Kinugawa; Kazunori Shimada; Sohsuke Yamada; Hiroyuki Hao; Daisaku Nakatani; Tomomi Ide; Tetsuya Amano; Hiroaki Naito; Hironori Nagasaka; Kunihisa Kobayashi
Orphanet journal of rare diseases, 11 Jun. 2019, Refereed

Circular IRE-type RNAs of the NR5A1 gene are formed in adrenocortical cells.
Kenji Ohe; Tomoko Tanaka; Yuta Horita; Yoshihiro Harada; Takafumi Yamasaki; Ichiro Abe; Makito Tanabe; Takashi Nomiyama; Kunihisa Kobayashi; Munechika Enjoji; Toshihiko Yanase
Biochemical and biophysical research communications, 23 Apr. 2019, Refereed

Multicenter prospective observational study of teneligliptin, a selective dipeptidyl peptidase-4 inhibitor, in patients with poorly controlled type 2 diabetes
Takamiya Y; Okamura K; Shirai K; Okuda T; Kobayashi K; Urata H
Clin Exp Hypertens., 23 Apr. 2019, Refereed

Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma.
Ichiro Abe; Hideyuki Fujii; Hanako Ohishi; Kaoru Sugimoto; Midori Minezaki; Midori Nakagawa; Saori Takahara; Tadachika Kudo; Makiko Abe; Kenji Ohe; Toshihiko Yanase; Kunihisa Kobayashi
Endocrine journal, 28 Feb. 2019, Refereed

Potential Impact on Lipoprotein Subfractions in Type 2 Diabetes.
Yuka Kamijo; Hideto Ishii; Tomohiko Yamamoto; Kunihisa Kobayashi; Hiroyuki Asano; Shunji Miake; Eiichiro Kanda; Hidenori Urata; Masayuki Yoshida
Clinical medicine insights. Endocrinology and diabetes, 2019, Refereed

Investigation of efficacy and safety of low-dose sodium glucose transporter 2 inhibitors and differences between two agents, canagliflozin and ipragliflozin, in patients with type 2 diabetes mellitus.
Kaoru Sugimoto; Ichiro Abe; Midori Minezaki; Yuichi Takashi; Kentaro Ochi; Hideyuki Fujii; Hanako Ohishi; Yuka Yamao; Tadachika Kudo; Kenji Ohe; Makiko Abe; Yasushi Ohnishi; Tomohiro Shinagawa; Shigeaki Mukoubara; Kunihisa Kobayashi
Drug discoveries & therapeutics, 2019, Refereed

高LDLコレステロール血症
小林邦久
臨床と研究, 01 Jan. 2019

Two cases of mitochondrial diabetes in which pancreatic beta-cell function and neuropathy were improved by glucagon-like peptide-1 receptor agonist therapy.
Minezaki M; Abe I; Koga M; Sugimoto K; Takeshita K; Takahara S; Nakagawa M; Fujii H; Ohishi H; Kudo T; Ohe K; Yanase T; Kobayashi K
Journal of Endocrinology and Metabolism, 01 Jan. 2019, Refereed

Clinical Investigation of Adrenal Incidentalomas in Japanese Patients of the Fukuoka Region with Updated Diagnostic Criteria for Sub-clinical Cushing's Syndrome.
Ichiro Abe; Kaoru Sugimoto; Tetsumasa Miyajima; Tomoko Ide; Midori Minezaki; Kaori Takeshita; Saori Takahara; Midori Nakagawa; Yuki Fujimura; Tadachika Kudo; Shigero Miyajima; Hiroshi Taira; Kenji Ohe; Tatsu Ishii; Toshihiko Yanase; Kunihisa Kobayashi
Internal medicine (Tokyo, Japan), 01 Sep. 2018, Refereed

HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells.
Kenji Ohe; Shinsuke Miyajima; Ichiro Abe; Tomoko Tanaka; Yuriko Hamaguchi; Yoshihiro Harada; Yuta Horita; Yuki Beppu; Fumiaki Ito; Takafumi Yamasaki; Hiroki Terai; Masayoshi Mori; Yusuke Murata; Makito Tanabe; Kenji Ashida; Kunihisa Kobayashi; Munechika Enjoji; Toshihiko Yanase; Nobuhiro Harada; Toshiaki Utsumi; Akila Mayeda
The Journal of steroid biochemistry and molecular biology, Sep. 2018, Refereed

Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy.
Akira Suzuki; Satoshi Yamaguchi; Ming Li; Yasuhiro Hara; Hideyuki Miyauchi; Yoshihiko Ikeda; Bo Zhang; Masahiro Higashi; Yasuyuki Ikeda; Atsuko Takagi; Hironori Nagasaka; Kunihisa Kobayashi; Yasuhiro Magata; Toshiaki Aoyama; Ken-Ichi Hirano
Journal of oleo science, 01 Aug. 2018, Refereed

Definitive diagnosis of mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome caused by a recurrent de novo mutation in the POLD1 gene.
Haruka Sasaki; Kumiko Yanagi; Satoshi Ugi; Kunihisa Kobayashi; Kumiko Ohkubo; Yuji Tajiri; Hiroshi Maegawa; Atsunori Kashiwagi; Tadashi Kaname
Endocrine journal, 26 Feb. 2018, Refereed

Diagnostic Criteria and Severity Score for Triglyceride Deposit Cardiomyovasculopathy
Hideyuki Miyauchi; Chikako Hashimoto; Yoshihiko Ikeda; Ming Li; Yusuke Nakano; Junji Kozawa; Eiryu Sai; Yasuyuki Nagasawa; Koichiro Sugimura; Shintaro Kinugawa; Katsuhiro Kawaguchi; Kazunori Shimada; Tomomi Ide; Tetsuya Amano; Masahiro Higashi; Tohru Inaba; Hiroshi Nakamura; Kunihisa Kobayashi; Ken-ichi Hirano
Annals of Nuclear Cardiology, 2018

Persistent Primary Aldosteronism Despite Iatrogenic Adrenal Hemorrhage After Adrenal Vein Sampling.
Keisuke Okamura; Tetsu Okuda; Kazuyuki Shirai; Ichiro Abe; Kunihisa Kobayashi; Tatsu Ishii; Seiji Haraoka; Hidenori Urata
Journal of clinical medicine research, Jan. 2018

Newly developed selective immunoinactivation assay revealed reduction in adipose triglyceride lipase activity in peripheral leucocytes from patients with idiopathic triglyceride deposit cardiomyovasculopathy.
Atsuko Takagi; Yasuyuki Ikeda; Kunihisa Kobayashi; Kazuhiro Kobayashi; Yoshihiko Ikeda; Junji Kozawa; Hideyuki Miyauchi; Ming Li; Chikako Hashimoto; Yasuhiro Hara; Satoshi Yamaguchi; Akira Suzuki; Tatsushi Toda; Hironori Nagasaka; Ken-Ichi Hirano
Biochemical and biophysical research communications, 01 Jan. 2018

Investigation of metabolic and circulatory parameters that predict effects of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, on blood glucose and body weight in a retrospective, multicenter study
Kudo T; Abe I; Minezaki M; Sugimoto K; Fujii H; Ohishi H; Nakagawa M; Yano S; Matsubayashi S; Fukudome M; Ninomiya H; Ishii H; Kodera T; Ito H; Maeda Y; Kobayashi K
J Diabetes Metab, 2018, Refereed

HMGA1a Induces Alternative Splicing of the Estrogen Receptor-αlpha Gene by Trapping U1 snRNP to an Upstream Pseudo-5' Splice Site.
Kenji Ohe; Shinsuke Miyajima; Tomoko Tanaka; Yuriko Hamaguchi; Yoshihiro Harada; Yuta Horita; Yuki Beppu; Fumiaki Ito; Takafumi Yamasaki; Hiroki Terai; Masayoshi Mori; Yusuke Murata; Makito Tanabe; Ichiro Abe; Kenji Ashida; Kunihisa Kobayashi; Munechika Enjoji; Takashi Nomiyama; Toshihiko Yanase; Nobuhiro Harada; Toshiaki Utsumi; Akila Mayeda
Frontiers in molecular biosciences, 2018, Refereed

The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study
Hiroshi Nitta; Sayaka Katagiri; Toshiyuki Nagasawa; Yuichi Izumi; Isao Ishikawa; Hajime Izumiyama; Isao Uchimura; Masao Kanazawa; Hiroshige Chiba; Akira Matsuo; Kazunori Utsunomiya; Haruyasu Tanabe; Izumi Takei; Soichiro Asanami; Hiroshi Kajio; Toaki Ono; Yoichi Hayashi; Kiichi Ueki; Masatomi Tsuji; Yoichi Kurachi; Toshikazu Yamanouchi; Yoshimi Ichinokawa; Toshiki Inokuchi; Akiko Fukui; Shigeru Miyazaki; Takashi Miyauchi; Reiko Kawahara; Hideki Ogiuchi; Narihito Yoshioka; Jun Negishi; Masatomo Mori; Kenji Mogi; Yasushi Saito; Hideki Tanzawa; Tetsuo Nishikawa; Norihiko Takada; Kishio Nanjo; Nobuo Morita; Naoto Nakamura; Narisato Kanamura; Hirofumi Makino; Fusanori Nishimura; Kunihisa Kobayashi; Yoshinori Higuchi; Toshiie Sakata; Shigetaka Yanagisawa; Chuwa Tei; Yuichi Ando; Nobuhiro Hanada; Shuji Inoue
JOURNAL OF DIABETES INVESTIGATION, Sep. 2017, Refereed

Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy
Higashi Masahiro; Ikeda Yoshihiko; Miyauchi Hideyuki; Zaima Nobuhiro; Suzuki Akira; Li Ming; Kobayashi Kunihisa; Naito Hiroaki; Hirano Ken-ichi
Annals of Nuclear Cardiology, 2017

Novel subtype of congenital partial lipodystrophy with mandibular hypoplasia, sensorineural deafness and short stature of unknown genetic origin
Haruka Sasaki; Kumiko Ohkubo; Kunihisa Kobayashi; Yuji Tajiri; Satoshi Ugi; Atsunori Kashwagi
J Diabetes Investig, 2017, Refereed

16年間に慢性甲状腺炎・自己免疫性肝炎・緩徐進行1型糖尿病・全身性エリテマトーデスを発症した1例
Yanagita Ikumi; Kamiya Akiko; Sugimoto Kaoru; Noda Tomohiro; Nagasako Hisahiro; Noma Eijiro; Haraoka Seiji; Maruoka Hiroshi; Sugimura Takashi; Kodera Takehiko; Abe Ichiro; Kudo Tadachika; Kobayashi Kunihisa
Journal of the Japan Diabetes Society, 2016, Refereed

Efficacy and safety of low-dose ipragliflozin, a selective sodium glucose transporter 2 inhibitor, in patients with type 2 diabetes mellitus
Abe, I; Ohnishi Y; Koga M; Sugimoto K; Kudo T; Kobayashi K; Mukobara S
Int J of Allied Med Sci and Clin Res., 2016, Refereed

Hyperinsulinemia and sulfonylurea use are independently associated with left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus with suboptimal blood glucose control.
Inoue T; Maeda Y; Sonoda N; Sasaki S; Kabemura T; Kobayashi K; Inoguchi T
BMJ Open Diabetes Res Care, 2016, Refereed

Distinct cardiac phenotype between two homozygotes born in a village with accumulation of a genetic deficiency of adipose triglyceride lipase
Masahiro Higashi; Ken-ichi Hirano; Kazuhiro Kobayashi; Yoshihiko Ikeda; Ami Issiki; Tetsuo Otsuka; Akira Suzuki; Satoshi Yamaguchi; Nobuhiro Zaima; Seiki Hamada; Hironori Hanada; Chieko Suzuki; Hiroshi Nakamura; Hironori Nagasaka; Toshiyuki Miyata; Yoshihiro Miyamoto; Kunihisa Kobayashi; Hiroaki Naito; Tatsushi Toda
INTERNATIONAL JOURNAL OF CARDIOLOGY, Aug. 2015, Refereed

Efficacy of dipeptidyl peptidase-4 inhibitor linagliptin in patients with type 2 diabetes undergoing hemodialysis
Yuichi Terawaki; Takashi Nomiyama; Hiroyuki Takahashi; Yoko Tsutsumi; Kunitaka Murase; Ryoko Nagaishi; Makito Tanabe; Tadachika Kudo; Kunihisa Kobayashi; Tetsuhiko Yasuno; Hitoshi Nakashima; Toshihiko Yanase
DIABETOLOGY & METABOLIC SYNDROME, May 2015, Refereed

Predictive Approaches for Low-Cost Preventive Medicine Program in Developing Countries
Yukino Baba; Tatsuo Hiramatsu; Michio Kimura; Shuji Shimizu; Kunihisa Kobayashi; Koji Tsuda; Masashi Sugiyama; Mathieu Blondel; Naonori Ueda; Masaru Kitsuregawa; Naoki Nakashima; Hisashi Kashima; Yasunobu Nohara; Eiko Kai; Partha Ghosh; Rafiqul Islam; Ashir Ahmed; Masahiro Kuroda; Sozo Inoue
Proceedings of the 21th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining - KDD '15, 2015

Complete remission of anaplastic thyroid carcinoma after concomitant treatment with docetaxel and radiotherapy.
Abe I; Karasaki S; Matsuda Y; Sakamoto S; Nakashima T; Yamamoto H; Kawate H; Ohnaka K; Nakashima H; Kobayashi K; Oda Y; Nomura M; Takayanagi R
Case Rep Endocrinol., 2015, Refereed

Health Checkup and Telemedical Intervention Program for Preventive Medicine in Developing Countries: Verification Study
Yasunobu Nohara; Eiko Kai; Partha Pratim Ghosh; Rafiqul Islam; Ashir Ahmed; Masahiro Kuroda; Sozo Inoue; Tatsuo Hiramatsu; Michio Kimura; Shuji Shimizu; Kunihisa Kobayashi; Yukino Baba; Hisashi Kashima; Koji Tsuda; Masashi Sugiyama; Mathieu Blondel; Naonori Ueda; Masaru Kitsuregawa; Naoki Nakashima
JOURNAL OF MEDICAL INTERNET RESEARCH, Jan. 2015, Refereed

Coronary triglyceride deposition in contemporary advanced diabetics
Yoshihiko Ikeda; Nobuhiro Zaima; Ken-ichi Hirano; Masayuki Mano; Kunihisa Kobayashi; Sohsuke Yamada; Satoshi Yamaguchi; Akira Suzuki; Hideaki Kanzaki; Toshimitsu Hamasaki; Jun-ichi Kotani; Seiya Kato; Hironori Nagasaka; Mitsutoshi Setou; Hatsue Ishibashi-Ueda
PATHOLOGY INTERNATIONAL, Jul. 2014, Refereed

Genetic mutations in adipose triglyceride lipase and myocardial up-regulation of peroxisome proliferated activated receptor-gamma in patients with triglyceride deposit cardiomyovasculopathy
Ken-ichi Hirano; Tatsuya Tanaka; Yoshihiko Ikeda; Satoshi Yamaguchi; Nobuhiro Zaima; Kazuhiro Kobayashi; Akira Suzuki; Yasuhiko Sakata; Yasushi Sakata; Kunihisa Kobayashi; Tatsushi Toda; Norihide Fukushima; Hatsue Ishibashi-Ueda; Daniela Tavian; Hironori Nagasaka; Shu-Ping Hui; Hitoshi Chiba; Yoshiki Sawa; Masatsugu Hori
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2014, Refereed

Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice
Tomoaki Inoue; Kunihisa Kobayashi; Toyoshi Inoguchi; Noriyuki Sonoda; Yasutaka Maeda; Eiichi Hirata; Yoshinori Fujimura; Daisuke Miura; Ken-ichi Hirano; Ryoichi Takayanagi
Biochemical and Biophysical Research Communications, 16 Aug. 2013, Refereed

CTLA-4Ig immunotherapy of obesity-induced insulin resistance by manipulation of macrophage polarization in adipose tissues
Masakazu Fujii; Toyoshi Inoguchi; Battsetseg Batchuluun; Naonobu Sugiyama; Kunihisa Kobayashi; Noriyuki Sonoda; Ryoichi Takayanagi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2013, Refereed

Evaluation of "Portable Health Clinic" with BAN standard for 10K subjects in Bangladesh
Naoki Nakashima; Tatsuo Hiramatsu; Partha Pratim Ghosh; Rafiqul Islam; Kunihisa Kobayashi; Toyoshi Inoguchi
2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), Jul. 2013, Refereed

An Affordable, Usable and Sustainable Preventive Healthcare System for Unreached People in Bangladesh.
Naoki Nakashima; Yasunobu Nohara; Ashir Ahmed; Masahiro Kuroda; Sozo Inoue; Partha Pratim Ghosh; Rafiqul Islam Maruf; Tatsuo Hiramatsu; Kunihisa Kobayashi; Toyoshi Inoguchi; Masaru Kitsuregawa
MEDINFO 2013 - Proceedings of the 14th World Congress on Medical and Health Informatics(MedInfo), 2013

Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress
Jing Zheng; Toyoshi Inoguchi; Shuji Sasaki; Yasutaka Maeda; Mark F. McCarty; Masakazu Fujii; Noriko Ikeda; Kunihisa Kobayashi; Noriyuki Sonoda; Ryoichi Takayanagi
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Jan. 2013, Refereed

Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4-associated oxidative stress in diabetic hamsters
Yasutaka Maeda; Toyoshi Inoguchi; Ryoko Takei; Hari Hendarto; Makoto Ide; Tomoaki Inoue; Kunihisa Kobayashi; Hidenori Urata; Akira Nishiyama; Ryoichi Takayanagi
JOURNAL OF DIABETES INVESTIGATION, Aug. 2012

2型糖尿病関連中性脂肪蓄積心筋血管症
平野 賢一; 池田 善彦; 財満 信宏; 眞能 正幸; 小林 邦久; 神崎 秀明; 加藤 誠也; 笹栗 靖之; 友池 仁暢; 瀬藤 光利; 植田 初江
日本病理学会会誌, Mar. 2012

我が国で見いだされた新規疾患単位、中性脂肪蓄積心筋血管症 希少難病からcommon diseaseへの展開
平野 賢一; 財満 信宏; 池田 善彦; 眞能 正幸; 小林 邦久; 神崎 秀明; 北風 政史; 小室 一成; 瀬藤 光利; 友池 仁暢
日本内科学会雑誌, Feb. 2012

A case report of type 2 diabetes mellitus with biatrial thrombi and pulmonary embolism caused by atrial fibrillation: Successful treatment with anticoagulant therapy
Tomoaki Inoue; Kunihisa Kobayashi; Takefumi Katsuragi; Isao Ichino; Seiichi Tanaka; Masafumi Haji; Toyoshi Inoguchi; Ryoichi Takayanagi
Diabetology International, Dec. 2011, Refereed

Reduced Expression of Adipose Triglyceride Lipase Enhances Tumor Necrosis Factor alpha-induced Intercellular Adhesion Molecule-1 Expression in Human Aortic Endothelial Cells via Protein Kinase C-dependent Activation of Nuclear Factor-kappa B
Tomoaki Inoue; Kunihisa Kobayashi; Toyoshi Inoguchi; Noriyuki Sonoda; Masakazu Fujii; Yasutaka Maeda; Yoshinori Fujimura; Daisuke Miura; Ken-ichi Hirano; Ryoichi Takayanagi
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2011, Refereed

Biliverdin protects against the deterioration of glucose tolerance in db/db mice
N. Ikeda; T. Inoguchi; N. Sonoda; M. Fujii; R. Takei; E. Hirata; H. Yokomizo; J. Zheng; Y. Maeda; K. Kobayashi; R. Takayanagi
DIABETOLOGIA, Aug. 2011, Refereed

Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters
Yasutaka Maeda; Toyoshi Inoguchi; Ryoko Takei; Fumi Sawada; Shuji Sasaki; Masakazu Fujii; Kunihisa Kobayashi; Hidenori Urata; Akira Nishiyama; Ryoichi Takayanagi
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, Dec. 2010

Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase
Masakazu Fujii; Toyoshi Inoguchi; Shuji Sasaki; Yasutaka Maeda; Jing Zheng; Kunihisa Kobayashi; Ryoichi Takayanagi
KIDNEY INTERNATIONAL, Nov. 2010, Refereed

粟粒結核に血球貪食症候群・播種性血管内凝固症候群・成人呼吸窮迫症候群・急性腎不全を合併した糖尿病患者の一例
井上智彰; 葛城武文; 國本政瑞沖; 市野 功; 田中誠一; 濱田哲夫; 小林邦久; 土師正文; 井口登與志; ?涼一
糖尿病, Apr. 2010, Refereed

A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins
Keiko Sakai; Oliver Tiebel; M. Cecilia Ljungberg; Merry Sullivan; Hye-Jeong Lee; Tomoya Terashima; Ronying Li; Kunihisa Kobayashi; Hui-Chen Lu; Lawrence Chan; Kazuhiro Oka
BRAIN RESEARCH, Jun. 2009

Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic beta-cell line, MIN6
Fumi Sawada; Toyoshi Inoguchi; Hirotaka Tsubouchi; Shuji Sasaki; Masakazu Fujii; Yasutaka Maeda; Hidetaka Morinaga; Masatoshi Nomura; Kunihisa Kobayashi; Ryoichi Takayanagi
METABOLISM-CLINICAL AND EXPERIMENTAL, Aug. 2008

The lack of the C-terminal domain of adipose triglyceride lipase causes neutral lipid storage disease through impaired interactions with lipid droplets
Kunihisa Kobayashi; Toyoshi Inoguchi; Yasutaka Maeda; Naoki Nakashima; Asako Kuwano; Erina Eto; Noriko Ueno; Shuji Sasaki; Fumi Sawada; Masakazu Fujii; Yuka Matoba; Shinji Sumiyoshi; Hisaya Kawate; Ryoichi Takayanagi
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Jul. 2008, Refereed

Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes
Toyoshi Inoguchi; Shuji Sasaki; Kunihisa Kobayashi; Ryoichi Takayanagi; Tomomi Yamada
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Sep. 2007

Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice
M. Fujii; T. Inoguchi; Y. Maeda; S. Sasaki; F. Sawada; R. Saito; K. Kobayashi; H. Sumimoto; R. Takayanagi
KIDNEY INTERNATIONAL, Aug. 2007

Gastric emptying in diabetic patients by the C-13-octanoic acid breath test: role of insulin in gastric motility
Masahiro Matsumoto; Rie Yoshimura; Hirotada Akiho; Naomi Higuchi; Kunihisa Kobayashi; Noriaki Matsui; Kentaro Taki; Hiroyuki Murao; Haruei Ogino; Kenji Kanayama; Yorinobu Sumida; Takahiro Mizutani; Kuniomi Honda; Shigetaka Yoshinaga; Soichi Itaba; Hiromi Muta; Naohiko Harada; Kazuhiko Nakamura; Ryoichi Takayanagi
JOURNAL OF GASTROENTEROLOGY, Jun. 2007

Molecular mechanisms of the antiatherogenic action of adiponectin
Kunihisa Kobayashi; Toyoshi Inoguchi
Vascular Disease Prevention, Feb. 2007

A Japanese Model of Disease Management
Naoki Nakashima; Kunihisa Kobayashi; Toyoshi Inoguchi; Daisuke Nishida; Naomi Tanaka; Hiromi Nakazono; Akihiko Hoshino; Hidehisa Soejima; Ryoichi Takayanagi; Hajime Nawata
MEDINFO 2007: PROCEEDINGS OF THE 12TH WORLD CONGRESS ON HEALTH (MEDICAL) INFORMATICS, PTS 1 AND 2, 2007

Therapeutic angiogenesis by ex vivo expanded erythroid progenitor cells
Shuji Sasaki; Toyoshi Inoguchi; Koichiro Muta; Yasunobu Abe; Min Zhang; Kenichi Hiasa; Kensuke Egashira; Noriyuki Sonoda; Kunihisa Kobayashi; Ryoichi Takayanagi; Hajime Nawata
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Jan. 2007

糖尿病疾病管理のための地域医療連携クリティカルパスの開発
小林邦久; 中島直樹; 井口登與志; 西田大介; 田中直美; 星乃明彦; 濱田倫朗; 小妻幸男; 中熊英貴; 松下龍之介; 副島秀久; 髙栁涼一; 名和田新
糖尿病, 2006, Refereed

Adipose differentiation related protein induces lipid accumulation and lipid droplet formation in hepatic stellate cells
M Fukushima; M Enjoji; M Kohjima; R Sugimoto; S Ohta; K Kotoh; M Kuniyoshi; K Kobayashi; M Imamura; T Inoguchi; M Nakamuta; H Nawata
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, Nov. 2005

Adiponectin inhibits the binding of low-density lipoprotein to biglycan, a vascular proteoglycan
K Kobayashi; T Inoguchi; N Sonoda; N Sekiguchi; H Nawata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2005

Erythropoietin attenuated high glucose-induced apoptosis in cultured human aortic endothelial cells
Naotaka Sekiguchi; Toyoshi Inoguchi; Kunihisa Kobayashi; Noriyuki Sonoda; Hajime Nawata
Biochemical and Biophysical Research Communications, 19 Aug. 2005, Refereed

Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement
H Tsubouchi; T Inoguchi; T Sonta; N Sato; N Sekiguchi; K Kobayashi; H Sumimoto; H Utsumi; H Nawata
FREE RADICAL BIOLOGY AND MEDICINE, Aug. 2005

Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist
M Nakayama; T Inoguchi; T Sonta; Y Maeda; S Sasaki; F Sawada; H Tsubouchi; N Sonoda; K Kobayashi; H Sumimoto; H Nawata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2005

Adipokines: Therapeutic targets for metabolic syndrome
K Kobayashi; T Inoguchi
CURRENT DRUG TARGETS, Jun. 2005

In vivo imaging of oxidative stress in the kidney of diabetic mice and its normalization by angiotensin II type 1 receptor blocker
T Sonta; T Inoguchi; S Matsumoto; K Yasukawa; M Inuo; H Tsubouchi; N Sonoda; K Kobayashi; H Utsumi; H Nawata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2005

Adenovirus-mediated high expression of resistin causes dyslipidemia in mice
N Sato; K Kobayashi; T Inoguchi; N Sonoda; M Imamura; N Sekiguchi; N Nakashima; H Nawata
ENDOCRINOLOGY, Jan. 2005

Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic β-cell line, MIN6?a role of NAD(P)H oxidase in β-cells.
Hirotaka Tsubouchi; Toyoshi Inoguchi; Mieko Inuo; Maiko Kakimoto; Toshiyo Sonta; Noriyuki Sonoda; Shuji Sasaki; Kunihisa Kobayashi; Hideki Sumimoto; Hajime Nawata
Biochemical and Biophysical Research Communications, 31 Dec. 2004

Evalution of oxidative stress in diabetic animals by in vivo electron spin resonance measurement - Role of protein kinase C
Toshiyo Sonta; Toyoshi Inoguchi; Hirotaka Tsubouchi; Naotaka Sekiguchi; Kunihisa Kobayashi; Shingo Matsumoto; Hideo Utsumi; Hajime Nawata
Diabetes Research and Clinical Practice, Dec. 2004

Evalution of oxidative stress in diabetic animals by in vivo electron spin resonance measurement--role of protein kinase C.
Toshiyo Sonta; Toyoshi Inoguchi; Hirotaka Tsubouchi; Naotaka Sekiguchi; Kunihisa Kobayashi; Shingo Matsumoto; Hideo Utsumi; Hajime Nawata
Diabetes research and clinical practice, Dec. 2004

Effect of erythropoietin on endothelial cell apoptosis induced by high glucose
Naotaka Sekiguchi; Toyoshi Inoguchi; Kunihisa Kobayashi; Hajime Nawata
Diabetes Research and Clinical Practice, Dec. 2004, Refereed

Evidence for contribution of vascular Nad(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity
T Sonta; T Inoguchi; H Tsubouchi; N Sekiguchi; K Kobayashi; S Matsumoto; H Utsumi; H Nawata
FREE RADICAL BIOLOGY AND MEDICINE, Jul. 2004

Resistin: A matter of mice and men
Kunihisa Kobayashi; Toyoshi Inoguchi; Hajime Nawata
Recent Res. Devel. Physiol., 2004

Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment
T Etoh; T Inoguchi; M Kakimoto; N Sonoda; K Kobayashi; J Kuroda; H Sumimoto; H Nawata
DIABETOLOGIA, Oct. 2003

Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase.
Toyoshi Inoguchi; Toshiyo Sonta; Hirotaka Tsubouchi; Takashi Etoh; Maiko Kakimoto; Noriyuki Sonoda; Naoichi Sato; Naotaka Sekiguchi; Kunihisa Kobayashi; Hideki Sumimoto; Hideo Utsumi; Hajime Nawata
Journal of the American Society of Nephrology : JASN, Aug. 2003

A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidase
Toyoshi Inoguchi; H. Tsubouchi; T. Etoh; M. Kakimoto; T. Sonta; H. Utsumi; H. Sumimoto; H. Y. Yu; N. Sonoda; M. Inuo; N. Sato; N. Sekiguchi; K. Kobayashi; H. Nawata
Current Medicinal Chemistry, 2003

ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts
M Imamura; T Inoguchi; S Ikuyama; S Taniguchi; K Kobayashi; N Nakashima; H Nawata
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Oct. 2002

A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing
PP Lau; H Villanueva; K Kobayashi; M Nakamuta; BHJ Chang; L Chan
JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2001

Gene therapy for diabetic dyslipidemia
Therapeutic Research, 2000

The db/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of Western diet feeding
K Kobayashi; TM Forte; S Taniguchi; BY Ishida; K Oka; L Chan
METABOLISM-CLINICAL AND EXPERIMENTAL, Jan. 2000, Refereed

Adenovirus-mediated human Topoisomerase II alpha gene transfer increases the sensitivity of etoposide-resistant human breast cancer cells
ZC Zhou; LA Zwelling; Y Kawakami; TH An; K Kobayashi; C Herzog; ES Kleinerman
CANCER RESEARCH, Sep. 1999

Adenovirus-mediated overexpression of microsomal triglyceride transfer protein (MTP): Mechanistic studies on the role of MTP in apolipoprotein B-100 biogenesis
W Liao; K Kobayashi; L Chan
BIOCHEMISTRY, Jun. 1999

Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor
MC Jong; KW Van Dijk; VEH Dahlmans; H Van der Boom; K Kobayashi; K Oka; G Siest; L Chan; MH Hofker; LM Havekes
BIOCHEMICAL JOURNAL, Mar. 1999

Resistance of chylomicron and VLDL remnants to postheparin lipolysis in ApoE-deficient mice: the role of apoE in lipoprotein lipase-mediated lipolysis in vivo and in vitro
E Zsigmond; Y Fuke; L Li; K Kobayashi; L Chan
JOURNAL OF LIPID RESEARCH, Sep. 1998

Phenotype interaction of apobec-1 and CETP, LDLR, and ApoE gene expression in mice - Role of ApoB mRNA editing in lipoprotein phenotype expression
M Nakamuta; S Taniguchi; BY Ishida; K Kobayashi; L Chan
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, May 1998

Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor
KW van Dijk; BJM van Vlijmen; A van der Zee; B van't Hof; H van der Boom; K Kobayashi; L Chan; LM Havekes; MH Hofker
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Jan. 1998

Production of rabbit polyclonal antibody against apobec-1 by genetic immunization
SCJ Yeung; J Anderson; K Kobayashi; K Oka; L Chan
JOURNAL OF LIPID RESEARCH, Dec. 1997

Adenovirus-mediated gene transfer of human lipoprotein lipase ameliorates the hyperlipidemias associated with apolipoprotein E and LDL receptor deficiencies in mice
E Zsigmond; K Kobayashi; KW Tzung; L Li; Y Fuke; L Chan
HUMAN GENE THERAPY, Nov. 1997

Molecular basis and promise of genetic therapy for diabetic dyslipidaemia: Studies in an animal model of diabetes
L Chan; K Kobayashi
DIABETOLOGIA, Jul. 1997

Molecular basis and promise of genetic therapy for diabetic dyslipidaemia: Studies in an animal model of diabetes
L Chan; K Kobayashi
DIABETOLOGIA, Jul. 1997

Effect of beraprost sodium on the increased transendothelial permeation of albumin induced by high concentration of glucose
K. Kobayashi; F. Umeda; T. Hashimoto; K. Mimura; T. Yamashita; H. Nawata
Fukuoka Acta Medica, 1997

Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice
K Oka; K Kobayashi; M Sullivan; J Martinez; BB Teng; K IshimuraOka; L Chan
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 1997

Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic: Background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of apobec-1
M Nakamuta; BHJ Chang; E Zsigmond; K Kobayashi; H Lei; BY Ishida; K Oka; E Li; L Chan
JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1996

Dehydroepiandrosterone markedly inhibits the accumulation of cholesteryl ester in mouse macrophage J774-1 cells
S Taniguchi; T Yanase; K Kobayashi; R Takayanagi; H Nawata
ATHEROSCLEROSIS, Sep. 1996

Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor
K Kobayashi; K Oka; T Forte; B Ishida; BB Teng; K IshimuraOka; M Nakamuta; L Chan
JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1996

Insulin resistance and atherosclerosis in non-insulin-dependent diabetes mellitus
Therapeutic Research, 1996

EFFECTS OF GLUCOSE AND AN ALDOSE REDUCTASE INHIBITOR ON ALBUMIN PERMEATION THROUGH A LAYER OF CULTURED BOVINE VASCULAR ENDOTHELIAL-CELLS
K MIMURA; F UMEDA; T YAMASHITA; K KOBAYASHI; T HOSHIMOTO; H NAWATA
HORMONE AND METABOLIC RESEARCH, Oct. 1995

METABOLISM OF OXIDIZED GLYCATED LOW-DENSITY-LIPOPROTEIN IN CULTURED BOVINE AORTIC ENDOTHELIAL-CELLS
K KOBAYASHI; J WATANABE; F UMEDA; M MASAKADO; Y ONO; S TANIGUCHI; T YANASE; T HASHIMOTO; Y SAKO; H NAWATA
HORMONE AND METABOLIC RESEARCH, Aug. 1995

GLYCATION ACCELERATES THE OXIDATION OF LOW-DENSITY-LIPOPROTEIN BY COPPER IONS
K KOBAYASHI; J WATANABE; F UMEDA; H NAWATA
ENDOCRINE JOURNAL, Aug. 1995

INCREASED TRANSENDOTHELIAL PERMEATION OF ALBUMIN BY HIGH GLUCOSE-CONCENTRATION
T YAMASHITA; K MIMURA; F UMEDA; K KOBAYASHI; T HASHIMOTO; H NAWATA
METABOLISM-CLINICAL AND EXPERIMENTAL, Jun. 1995

ALTERNATIVE MESSENGER-RNA SPLICING AND DIFFERENTIAL PROMOTER UTILIZATION DETERMINE TISSUE-SPECIFIC EXPRESSION OF THE APOLIPOPROTEIN-B MESSENGER-RNA-EDITING PROTEIN (APOBEC1) GENE IN MICE - STRUCTURE AND EVOLUTION OF APOBEC1 AND RELATED NUCLEOSIDE NUCLEOTIDE DEAMINASES
M NAKAMUTA; K OKA; J KRUSHKAL; K KOBAYASHI; M YAMAMOTO; WH LI; L CHAN
JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1995

ENHANCEMENT OF PROSTACYCLIN PRODUCTION IN CULTURED BOVINE AORTIC ENDOTHELIAL-CELLS BY OXIDIZED GLYCATED LOW-DENSITY-LIPOPROTEIN
K KOBAYASHI; J WATANABE; F UMEDA; S TANIGUCHI; M MASAKADO; T YAMAUCHI; H NAWATA
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, Apr. 1995

CATECHOL ESTROGENS ARE MORE POTENT ANTIOXIDANTS THAN ESTROGENS FOR THE CU2+-CATALYZED OXIDATION OF LOW OR HIGH-DENSITY-LIPOPROTEIN - ANTIOXIDATIVE EFFECTS OF STEROIDS ON LIPOPROTEINS
S TANIGUCHI; T YANASE; K KOBAYASHI; R TAKAYANAGI; M HAJI; F UMEDA; H NAWATA
ENDOCRINE JOURNAL, Dec. 1994

APOLIPOPROTEIN-E POLYMORPHISM AFFECTS THE RESPONSE TO PRAVASTATIN ON PLASMA APOLIPOPROTEINS IN DIABETIC-PATIENTS
J WATANABE; K KOBAYASHI; F UMEDA; T YAMAUCHI; K MIMURA; N NAKASHIMA; M MASAKADO; S HIRAMATSU; H NAWATA
DIABETES RESEARCH AND CLINICAL PRACTICE, Apr. 1993

A case report of diabetic nephropathy treated with recombinant human erythropoietin.
Rinsho to Kenkyu, 1991

【『DM Ensemble』10年の振り返りと新創刊に向けて】
小林 邦久; 稲垣 美智子; 堀川 幸男; 亀山 亜希夫; 本田 寛人; 高野 直久; 脇 裕典
DM Ensemble, Nov. 2022

7腎症重症化予防のために 糖尿病医の立場から
小林 邦久
筑紫, Sep. 2022

糖尿病患者の心臓拡張機能に影響を与える因子の検討
井上 智彰; 井口 登與志; 小林 邦久; 園田 紀之; 前野 彩香; 佐々木 修二; 高柳 涼一
糖尿病, Aug. 2015

糖尿病患者の心臓拡張機能に影響を与える因子の検討
前野 彩香; 井上 智彰; 井口 登與志; 小林 邦久; 園田 紀之; 佐々木 修二; 高柳 涼一
糖尿病, Apr. 2015

両心房内巨大血栓および肺塞栓症をきたした心房細動合併2型糖尿病の一例
井上 智彰; 市野 功; 田中 誠一; 小林 邦久; 土師 正文; 井口 登與志; 高柳 涼一
糖尿病, Jul. 2011

藻類スピルリナより精製したフィコシアニンとフィコシアノビリンの糖尿病性腎症改善効果の検討
鄭 静; 井口 登與志; 藤井 雅一; 前田 泰孝; 池田 紀子; 武井 涼子; 平田 英一; 横溝 久; 佐藤 美紀子; 小林 邦久; 高柳 涼一
Diabetes Frontier, Oct. 2010

粟粒結核に血球貪食症候群・DIC・ARDS・急性腎不全を合併した糖尿病患者の1例
井上 智彰; 葛城 武文; 國本 政瑞沖; 市野 功; 田中 誠一; 渡辺 秀幸; 濱田 哲夫; 小林 邦久; 土師 正文; 井口 登與志; 高柳 涼一
糖尿病, Apr. 2010

全身性中性脂肪蓄積症におけるATGL遺伝子変異と細胞内局在
小林 邦久; 井上 智彰; 前田 泰孝; 佐藤 美紀子; 井手 誠; 武井 涼子; 藤井 雅一; 中島 直樹; 井口 登與志; 高柳 涼一
糖尿病, Apr. 2010

脂肪滴関連蛋白Adipose Differentiation-related Protein(ADRP)トランスジェニックマウスの解析(第3報)
園田 紀之; 小林 邦久; 今村 美菜子; 鄭 静; 前田 泰孝; 澤田 布美; 佐々木 修二; 中山 三枝子; 西藤 亮子; 森永 秀孝; 野村 政壽; 谷口 晋; 生山 祥一郎; 名和田 新; 井口 登與志
糖尿病, Apr. 2006

Subclinical Sjogren 症候群を合併した1型糖尿病の2例
SASAKI S.; INOGUCHI T.; OHTSUKA R.; SONTA T.; TSUBOUCHI H.; SATO N.; ETOH T.; SONODA N.; SEKIGUCHI N.; KOBAYASHI K.; NAWATA H.
Journal of the Japan Diabetes Society, 28 Feb. 2005

Overexpression of ADRP in transgenic mice leads to lipid accumulation and metabolic disorders
N Sonoda; T Inoguchi; M Imamura; H Morinaga; K Kobayashi; T Etoh; N Sato; N Sekiguchi; M Nomura; S Taniguchi; S Ikuyama; H Nawata
DIABETES, Jun. 2004

特異なインスリン過剰分泌反応を呈し,ボグリボースで改善を認め,アセタゾラミド併用で症状が消失した特発性低カリウム性周期性四肢麻痺の1例
坪内 博孝; 井口 登與志; 孫田 淑代; 許斐 朝子; 今村 美菜子; 江藤 隆; 垣本 真如子; 佐藤 直市; 小林 邦久; 中島 直樹; 野村 政壽; 名和田 新
Journal of the Japan Diabetes Society, 30 Jan. 2003

日本再生のための医療連携
中島 直樹; 井口 登與志; 髙栁涼一, Joint work, 147-152
ライフメディコム, Nov. 2012

糖尿病細小血管症
Joint work, 45-48
日本臨床, Nov. 2010

コメディカル・研修医・一般臨床医のための糖尿病治療ハンドブック－基本的な考え方とその実践・心理的アプローチ－
Joint work
医学出版, Apr. 2009

見直されたビグアナイド 塩酸メトホルミン 改訂版
Joint work
フジメディカル出版, 2009

地域医療連携パスの作成術・活用術 診療ネットワークづくりをめざして
Single work
医学書院, 2007

見直されたビグアナイド 塩酸メトホルミン
Joint work
フジメディカル出版, 2005

Very low density lipoprotein receptor gene therapy in a mouse model of familial hypercholesterolemia.<BR>(1996)
Joint work, 249-253
Drugs Affecting Lipid Metabolism, 1996

Very low density lipoprotein receptor gene therapy in a mouse model of familial hypercholesterolemia.
(1996)
Joint work, 249-253
Drugs Affecting Lipid Metabolism, 1996

糖尿病における脂質代謝異常
小林邦久
第59回日本糖尿病学会九州地方会, 19 Nov. 2021

医療者・保険者の協働をサポートする遠隔疾病管理
第12回日本プライマリ・ケア連合学会学術大会, 21 May 2021, 日本プライマリ・ケア連合学会

保険者が推進する遠隔医療
小林邦久; 西田大介; 日山富士代; 中島直樹; 井口登與志
日本糖尿病学会第58回九州地方会, 12 Oct. 2020, 日本糖尿病学会九州支部

下垂体偶発腫の臨床的特徴における検討 二施設共同研究
石井 康大; 阿部 一朗; 亀田 亘; 森永 裕介; 伊藤 美以子; 羽田 幸里香; 高瀬 薫; 杉本 薫; 藤井 秀幸; 大石 華子; 越智 健太郎; 山尾 有加; 峯崎 みどり; 高士 祐一; 工藤 忠睦; 阿部 真紀子; 東 登志夫; 園田 順彦; 石澤 賢一; 小林 邦久
日本内分泌学会雑誌, Aug. 2020, (一社)日本内分泌学会

中性脂肪について知っておきたいこと－糖尿病患者のよりよい脂質管理のために－
小林邦久
第11回 日本プライマリ・ケア連合学会学術大会, 23 Jul. 2020

「みえる・つながる」を意識した療養指導
小林邦久; 西田大介; 日山富士代; 中島直樹; 井口登與志
第57回日本糖尿病学会九州地方会, 26 Oct. 2019

高中性脂肪血症の成因
小林 邦久
中性脂肪学会第2回学術集会, 17 Nov. 2018, 中性脂肪学会

糖尿病と中性脂肪代謝異常
小林邦久
第52回 糖尿病学の進歩, 03 Mar. 2018, 日本糖尿病学会

高インスリン血症とスルフォニルウレア剤の使用は独立して左心室拡張機能障害と関連する
井上 智彰; 前田 泰孝; 園田 紀之; 小林 邦久; 佐々木 修二; 小川 佳宏; 井口 登與志
糖尿病, Apr. 2017, (一社)日本糖尿病学会

糖尿病状態における脂質代謝異常に対する新しいアプローチ
小林邦久
第53回 日本糖尿病学会九州地方会, 27 Nov. 2015, 日本糖尿病学会

パンデミックとしての肥満と糖尿病
小林邦久
西日本肥満研究会, 12 Jul. 2015

細胞内脂質代謝と臓器機能
小林邦久
Forum on Growth Hormone Research 2014, 10 May 2014

糖尿病治療の最近のトピックス
小林邦久
第304回日本内科学会九州地方会 第49回九州支部主催生涯教育講演会, 19 Jan. 2014

The Diabetes Pandemic ~an Introduction~
Kunihisa Kobayashi
35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society in conjunction with 52nd Annual Conference of Japanese Society for Medical and Biological Engineering, 03 Jul. 2013

糖尿病－最近の知見と求められる医療連携のかたち
小林邦久
第27回日本糖尿病合併症学会, 02 Nov. 2012

新時代の糖尿病治療におけるディジーズマネジメントの重要性 〜最新・最善の医療を患者さんに届けるために〜
第62回日本病院学会, 21 Jun. 2012

糖尿病は検査の病気 〜合併症の発症・進展を予防するために〜
Kunihisa Kobayashi
第23回日本臨床化学会 九州支部総会・第57回日本臨床検査医学会 九州地方会 合同総会, 11 Feb. 2012

RNA interference-directed Knockdown of Adipose Triglyceride Lipase Enhanced TNFalpha-induced ICAM-1 Expression in Human Aortic Endothelial Cells via PKC-dependent activation of NFk B
Kunihisa Kobayashi; Tomoaki Inoue
The First International Symposium on TGCV and NLSD, 26 Nov. 2011

シンポジウム2「2型糖尿病治療におけるインクレチン関連薬の位置付け」 DPP-4阻害薬
小林 邦久
第49回日本糖尿病学会九州地方会, Oct. 2011

糖尿病性腎症患者アルブミン尿に対するピタバスタチンおよびプラバスタチンの治療効果の比較検討 無作為化非盲検群間比較試験
木村 佐和; 井口 登與志; 松本 雅裕; 渡辺 淳; 田仲 秀明; 山内 照章; 小林 邦久; 正門 光法; 関口 直孝; 横山 寛明; 藤井 雅一; 佐々木 修二; 前田 泰孝; 武井 涼子; 井手 誠; 前田 麻木; 横溝 久; 井上 智彰; 工藤 佳奈; 高柳 涼一
糖尿病, Apr. 2011, (一社)日本糖尿病学会

地域医療連携クリティカルパスをもちいた糖尿病ディジーズマネジメント
小林 邦久
第21回日本在宅医療学会学術集会, Jun. 2010

Endocrinological Features of Triglyceride Deposit Cardiomyovasculopathy
Kunihisa Kobayashi; Tomoaki Inoue; Toyoshi Inoguchi; Ryoichi Takayanagi
XX World Congress of International Society for Heart Research, May 2010

膵β細胞機能評価としてのプロインスリン/CPR比の検討(第2報)
鴨井 佐和; 井口 登與志; 月本 賢美; 的場 ゆか; 藤井 雅一; 前田 泰孝; 平田 英一; 横溝 久; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2010, (一社)日本糖尿病学会

ビリベルジンによる糖尿病発症抑制の分子機序に関する検討
池田 紀子; 井口 登與志; 藤井 雅一; 前田 泰孝; 武井 涼子; 平田 英一; 横溝 久; 鄭 静; 佐藤 美紀子; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2010, (一社)日本糖尿病学会

胎生期・母乳期の高脂肪食摂取による耐糖能変化に関する検討
横溝 久; 井口 登與志; 藤井 雅一; 前田 泰孝; 平田 英一; 佐藤 美紀子; 武井 涼子; 池田 紀子; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2010, (一社)日本糖尿病学会

ビリルビン・ビリベルジンの糸球体・メサンギウム細胞へのNOX4発現抑制効果の検討
藤井 雅一; 井口 登與志; 前田 泰孝; 平田 英一; 池田 紀子; 武井 涼子; 横溝 久; 佐藤 美紀子; 鄭 静; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2010, (一社)日本糖尿病学会

藻類スピルリナより精製したフィコビリンの糖尿病性腎症改善効果の検討
鄭 静; 井口 登與志; 藤井 雅一; 前田 泰孝; 池田 紀子; 武井 涼子; 平田 英一; 横溝 久; Hari Hendarto; 井手 誠; 井上 智彰; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2010, (一社)日本糖尿病学会

当科における全身性中性脂肪蓄積症のATGL変異が核局在を惹起する機序の検討
小林 邦久; 井口 登與志; 井上 智彰; 前田 泰孝; 佐藤 美紀子; 井手 誠; 横溝 久; 平田 英一; 鄭 静; Hendarto Hari; 池田 紀子; 武井 涼子; 藤井 雅一; 中島 直樹; 高柳 涼一
糖尿病, Apr. 2010, (一社)日本糖尿病学会

胎生期・母乳期の高脂肪食摂取による耐糖能変化に関する検討
横溝 久; 井口 登與志; 藤井 雅一; 前田 泰孝; 平田 英一; 鄭 静; 武井 涼子; 池田 紀子; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2010, (一社)日本糖尿病学会

膵β細胞機能評価としてのプロインスリン/CPR比の検討
鴨井 佐和; 的場 ゆか; 藤井 雅一; 前田 泰孝; 平田 英一; 横溝 久; 月本 賢美; 小林 邦久; 井口 登與志; 高柳 涼一
糖尿病, Apr. 2010, (一社)日本糖尿病学会

藻類スピルリナより精製したフィコシアニンの糖尿病性腎症改善効果の検討(第二報)
鄭 静; 井口 登與志; 藤井 雅一; 前田 泰孝; 池田 紀子; 武井 涼子; 平田 英一; 横溝 久; 佐藤 美紀子; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2010, (一社)日本糖尿病学会

ビリベルジンによる糖尿病発症抑制の分子機序に関する研究
池田 紀子; 井口 登與志; 藤井 雅一; 前田 泰孝; 鄭 静; 武井 涼子; 平田 英一; 横溝 久; 佐藤 美紀子; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2010, (一社)日本糖尿病学会

事例に学ぶ医療連携－急性期から在宅まで－ 糖尿病ディジーズマネジメントのための地域医療連携クリティカルパス
小林 邦久
第59回日本病院学会, Jul. 2009

db/dbマウスにおけるビリベルジン投与による糖尿病発症抑制に関する研究
池田 紀子; 井口 登與志; 藤井 雅一; 前田 泰孝; 武井 涼子; 平田 栄一; 横溝 久; 井手 千晴; 佐藤 美紀子; 鄭 静; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2009, (一社)日本糖尿病学会

藻類スピルリナより精製したフィコシアニンの糖尿病腎症改善効果の検討
鄭 静; 井口 登與志; 江頭 絵里奈; 藤井 雅一; 前田 康孝; 池田 紀子; 武井 涼子; 佐藤 美紀子; 的場 ゆか; 平田 英一; 横溝 久; 井手 千晴; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2009, (一社)日本糖尿病学会

ビリルビンおよびビリベルジンはEts-1発現を抑制し、NAD(P)Hオキシダーゼ発現を制御することで、糖尿病性腎症改善効果を示す
藤井 雅一; 井口 登與志; 前田 泰孝; 平田 英一; 舩越 紀子; 武井 涼子; 鴨井 佐和; 横溝 久; 佐藤 美紀子; 鄭 静; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2009, (一社)日本糖尿病学会

二相性インスリンアナログ製剤を用いた段階的インスリン療法に関する検討
横溝 久; 井口 登與志; 藤井 雅一; 小林 邦久; 岡田 洋右; 川崎 英二; 水田 雅也; 中崎 満浩; 小宮 一郎; 岩瀬 正典; 名和田 新; 高柳 涼一
糖尿病, Apr. 2009, (一社)日本糖尿病学会

膵β細胞機能評価としてのプロインスリン/CPR比の検討
鴨井 佐和; 井口 登與志; 的場 ゆか; 藤井 雅一; 前田 泰孝; 平田 英一; 鄭 静; 武井 涼子; 池田 紀子; 横溝 久; 井手 千晴; 小林 邦久; 高柳 涼一
糖尿病, Apr. 2009, (一社)日本糖尿病学会

全身性中性脂肪蓄積症におけるAdipose triglyceride lipase(ATGL)の構造および細胞内局在の変化と機能との関係
小林 邦久; 井口 登與志; 前田 泰孝; 佐藤 美紀子; 横溝 久; 平田 英一; 井手 千晴; 鄭 静; Hendarto Hari; 鴨井 佐和; 池田 紀子; 武井 涼子; 藤井 雅一; 的場 ゆか; 中島 直樹; 高柳 涼一
糖尿病, Apr. 2009, (一社)日本糖尿病学会

シンポジウム２ エネルギー代謝，食シグナルと動脈硬化 The Lack of the C-terminal Domain of Adipose Triglyceride Lipase Causes Neutral Lipid Storage Disease Through Impaired Interactions with Lipid Droplets
KUNIHISA KOBAYASHI; TOYOSHI INOGUCHI; YASUTAKA MAEDA; MASAKAZU FUJII; RYOICHI TAKAYANAGI
第40回日本動脈硬化学会総会・学術集会, Jul. 2008

Chymase inhibitor prevented diabetic nephropathy via attenuation of oxidative stress and NAD(P)H oxidase expression in diabetic hamsters
Yasutaka Maeda; Toyoshi Inoguchi; Shuji Sasaki; Masakazu Fujii; Kunihisa Kobayashi; Hidenori Urata; Akira Nishiyama; Ryoichi Takayanagi
DIABETES, Jun. 2008, AMER DIABETES ASSOC

Hyperbilirubinemia and biliverdin administration ameliorates diabetic nephropathy via inhibition of oxidative stress in rodent models of diabetes
Toyoshi Inoguchi; Toyoshi Inoguchi; Syuji Sasaki; Yasutaka Maeda; Kunihisa Kobayashi; Ryoichi Taka-Yanagi
DIABETES, Jun. 2008, AMER DIABETES ASSOC

The lack of the C-terminal domain of adipose triglyceride lipase causes neutral lipid storage disease though impaired interactions with lipid droplets
Kunihisa Kobayashi; Toyoshi Inoguchi; Yasutaka Maeda; Masakazu Fuji; Ryoichi Takayanagi
DIABETES, Jun. 2008, AMER DIABETES ASSOC

The Lack of the C-terminal Domain of Adipose Triglyceride Lipase Causes Neutral Lipid Storage Disease Through Impaired Interactions with Lipid Droplets.
KUNIHISA KOBAYASHI; TOYOSHI INOGUCHI; YASUTAKA MAEDA; MASAKAZU FUJII; RYOICHI TAKAYANAGI
68th Scientific Sessions of American Diabetes Association, Jun. 2008

A case report of congenital generalized lipodystrophy type2 with severe insulin resistance.
Kunihisa Kobayashi; Noriyuki Sonoda; Toyoshi Inoguchi; Ryoichi Takayanagi
The 8th Insulin Action Symposium, Sep. 2006

Adiponectin inhibits the binding of low-density lipoprotein to biglycan, a vascular proteoglycan.
Kunihisa Kobayashi; Toyoshi Inoguchi; Noriyuki Sonoda; Naotaka Sekiguchi; Hajime Nawata
64th Scientific Sessions of American Diabetes Association, Jun. 2004

フォーサイトレクチャー9 リポ蛋白リパーゼによるカイロミクロン・VLDL加水分解におけるアポ蛋白Eの役割－アデノウイルスを用いた検討－
小林邦久; 梅田文夫; 名和田新; Lawrence Chan
平成11年度日本動脈硬化学会冬季大会, Nov. 1999

Molecular Pathogenesis of Diabetic Dyslipidemia in C57BL/ KsJ-db/db Mice.
K. Kobayashi; T. Forte; L. Chan
The Second EASD/JDF Oxford Conference "Cardiovascular Disease and Diabetes", Nov. 1996

Metabolism of oxidized glycated low density lipoprotein by cultured bovine endothelial cells.
Kunihisa Kobayashi; Mitsunori Masakado; Jun Watanabe; Susumu Taniguchi; Yasuhiro Ono; Kenichi Iwashige; Toshihiko Yanase; Toshihiko Hashimoto; Yasuhiro Sako; Fumio Umeda; Hajime Nawata
Symposium on vascular complications of diabetes mellitus, 06 Oct. 1993

日本糖尿病協会

日本糖尿病療養指導士認定機構

Society for Triglyceride Biology and Medicine

日本病態栄養学会

アジア糖尿病学会

The Japan Endocrine Society

日本クリニカルパス学会

米国糖尿病学会

日本老年医学会

The Japanese Society of Ophthalmic Diabetology

糖尿病合併症学会

日本動脈硬化学会

日本糖尿病学会

日本内科学会

中性脂肪蓄積心筋血管症の医療水準と患者QOLの向上に資する研究
厚生労働省, 厚生労働科学研究費, 開発研究
Apr. 2022 - Mar. 2024

中性脂肪蓄積心筋血管症の診療に直結するエビデンス創出研究
国立研究開発法人日本医療研究開発機構, 日本医療研究開発機構研究費
2020 - 2022

中性脂肪蓄積心筋血管症の診療体制の構築
厚生労働省, 難治性疾患政策研究事業
2020 - 2021

中性脂肪蓄積心筋血管症に対する中鎖脂肪酸を含有する医薬品の開発
AMED, research grants-in-aid for rare and intractable diseases
01 Apr. 2015 - 31 Mar. 2018

中性脂肪蓄積心筋血管症に対する中鎖脂肪酸を含有する医薬品の開発
AMED, research grants-in-aid for rare and intractable diseases
01 Apr. 2014 - 31 Mar. 2018

2025年問題（超高齢社会）に活用する個別性に対応した地域連携クリティカルパスの開発
The Small and Medium Enterprise Agency, Strategic Foundational Technology Improvement Support Operation
2015 - 2018

先端融合医療レドックスナビ研究拠点
文部科学省, イノベーションシステム整備事業
2011 - 2016

中性脂肪蓄積心筋血管症に対する中鎖脂肪酸を含有する医薬品の開発
厚生労働省, 厚生労働科学研究費補助金, research grants-in-aid for rare and intractable diseases
01 Apr. 2012 - 31 Mar. 2015

データヘルス計画と連携した糖尿病リモート医療
厚生労働省, 厚生労働科学研究費補助金
2014 - 2014

中性脂肪蓄積心筋血管症の病因・病態解明と診断法開発
厚生労働省, 厚生労働科学研究費補助金・難治性疾患克服研究事業
01 Apr. 2012 - 31 Mar. 2013

中性脂肪蓄積心筋血管症の発見-その疾患概念の確立、診断法、治療法の開発
厚生労働省, 厚生労働科学研究費補助金・難治性疾患克服研究事業
01 Apr. 2010 - 31 Mar. 2012

慢性疾患のガイドライン診療普及法の開発・実証研究
厚生労働省, 厚生労働科学研究費補助金
2008 - 2009

福岡県糖尿病対策推進会議
others
2018

筑紫保健所運営協議会救急医療部会
01 Apr. 2018