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Last Updated :2024/09/16

KOBAYASHI KUNIHISA


Professor

ProfileDyslipidemia and diabetes mellitus are major factors in the development of atherosclerosis and cardiovascular disease. I have been studying to elucidate the molecular and physiological basis of atherosclerosis as follows: 1) Effect of glycation on LDL oxidation, 2) Prostacyclin production stimulated by oxidized glycated LDL, 3) Amelioration of hypercholesterolemia in LDL receptor-deficient mice using adenoviral gene transfer of VLDL receptor, 4) The underlying mechanism of resistin-induced dyslipidemia 5) New anti-atherosclerotic action of adiponectin, 6) Effects of adipose triglyceride lipase, a causative gene of triglyceride deposit cardiomyovasuculopathy (TGCV a.k.a. neutral lipid storage disease), on intracellular glucose and lipid metabolism and on processes of atherosclerogenesis.

Researcher information

■ Degree
  • 博士(医学), 九州大学
■ Research Keyword
  • Gene therapy
  • Adiposcience
  • Disease management
  • Intracellular lipid metabolism
  • Diabetes
■ Field Of Study
  • Life sciences, Hygiene and public health (non-laboratory), Hygiene and public health
  • Life sciences, Hygiene and public health (laboratory), Hygiene and public health
  • Life sciences, Pathobiochemistry, Pathological Medical Chemistry
  • Life sciences, Molecular biology, Molecular Biology
  • Life sciences, Metabolism and endocrinology, Endocrinology
  • Life sciences, Metabolism and endocrinology, Metabolism Studies

Career

■ Career
  • Dec. 2020 - Present
    Fukuoka University Chikushi Hospital, Advisor to the President
  • Oct. 2010 - Present
    Fukuoka University Chikushi Hospital, Department of Endocrinology and Diabetes Mellitus, Professor
  • Dec. 2013 - Dec. 2020
    Fukuoka University Chikushi Hospital, Assistant director
  • 01 Apr. 2016 - 31 Mar. 2020
    School of Medicine, Kyushu University, Senior Lecturer (part-time)
  • 01 Jul. 2009 - 30 Sep. 2010
    Kyushu University Hospital, Department of Endocrine and Metabolic Diseases/ Diabetes Mellitus, Assistant professor
  • 01 Apr. 2007 - 30 Jun. 2009
    Graduate School of Medical Sciences, Kyushu University, Department of Medicine and Bioregulatory Science, Assistant professor
  • 01 Apr. 2001 - 31 May 2002
    Graduate School of Medical Sciences, Kyushu University, Department of Medicine and Bioregulatory Science, Instructor
  • 01 Apr. 1999 - 31 Mar. 2001
    National Kyushu Medical Center, Department of Endocrinology and Metabolism, Medical staff
  • 01 Jul. 1998 - 31 Mar. 1999
    Tenjin Clinic, Internal Medicine, Medical stuff
  • 13 Sep. 1994 - 30 Jun. 1998
    Baylor College of Medicine, Department of Cell Biology, Postdoctoral fellow
  • 01 Apr. 1994 - 10 Sep. 1994
    Itoda Town Hospital, Internal Medicine, Chief physician
  • 01 Apr. 1992 - 30 Mar. 1994
    Kyushu University Hospital, The Third Department of Internal Medicine, Clinical associate
  • 01 Jun. 1990 - 31 Mar. 1992
    Kyushu University, The Third Department of Internal Medicine, Research associate
  • 01 Jun. 1989 - 31 May 1990
    Kyushu Rosai Hospital, Internal Medicine, Doctor-in-training
  • 01 Jun. 1988 - 30 May 1989
    Kyushu University Hospital, Internal Medicine, Doctor-in-training

Research activity information

■ Award
  • 30 Jan. 2010
    福岡県医学会, 第2回福岡県医学会賞 奨励賞
    全身性中性脂肪蓄積症における脂肪滴関連リパーゼAdipose triglyceride lipase遺伝子異常の発見とその機能解析
■ Paper
  • A novel homozygous missense mutation in PNPLA2 in a patient manifesting primary triglyceride deposit cardiomyovasculopathy
    Yasuhiro Hara; Yoshihiko Ikeda; Hayato Kimura; Shinsaku Shimamoto; Mao Ishikawa; Kunihisa Kobayashi; Hironori Nagasaka; Hisashi Shimoyama; Ken-ichi Hirano
    Molecular Genetics and Metabolism Reports, Feb. 2023, Refereed
  • A simplified prediction model for end-stage kidney disease in patients with diabetes.
    Toyoshi Inoguchi; Tasuku Okui; Chinatsu Nojiri; Erina Eto; Nao Hasuzawa; Yukihiro Inoguchi; Kentaro Ochi; Yuichi Takashi; Fujiyo Hiyama; Daisuke Nishida; Fumio Umeda; Teruaki Yamauchi; Daiji Kawanami; Kunihisa Kobayashi; Masatoshi Nomura; Naoki Nakashima
    Scientific reports, 21 Jul. 2022, Refereed
  • Adrenal Hemorrhage in a Cortisol-Secreting Adenoma Caused by Antiphospholipid Syndrome Revealed by Clinical and Pathological Investigations: A Case Report
    Ochi K; Abe I; Yamazaki Y; Nagata M; Senda Y; Takeshita K; Koga M; Yamao Y; Shigeoka T; Kudo T; Fukuhara Y; Miyajima S; Taira H; Haraoka S; Ishii T; Takashi Y; Lam AK; Sasano H; Kobayashi K
    Front. Endocrinol., Feb. 2022, Refereed
  • Association of serum total bilirubin levels with progressive renal decline and end-stage kidney disease: 10-year observational cohort study in Japanese patients with diabetes.
    Erina Eto; Yasutaka Maeda; Noriyuki Sonoda; Naoki Nakashima; Kunihisa Kobayashi; Ryoichi Takayanagi; Yoshihiro Ogawa; Toyoshi Inoguchi
    PloS one, 2022, Refereed
  • 高LDLコレステロール血症
    越智健太郎; 小林邦久
    臨床と研究, 01 Jan. 2022
  • 【インタベ医に知って欲しい新たな冠動脈病変惹起性脂質代謝異常-中性脂肪蓄積心筋血管症(TGCV)-】TGCV診断基準2020
    小林 邦久
    Coronary Intervention, Sep. 2021
  • 生活習慣病の予防と治療 糖尿病
    小林邦久
    臨床と研究, Apr. 2021
  • Reduction in parathyroid adenomas by cinacalcet therapy in patients with primary hyperparathyroidism.
    Midori Minezaki; Yuichi Takashi; Kentaro Ochi; Ryo Mitsuoka; Yuka Yamao; Tadachika Kudo; Daiji Kawanami; Kunihisa Kobayashi; Ichiro Abe
    Journal of bone and mineral metabolism, 06 Jan. 2021, Refereed
  • Outside-in signaling by femoral cuff injury induces a distinct vascular lesion in adipose triglyceride lipase knockout mice.
    Hirotsugu Noguchi; Sohsuke Yamada; Ken-Ichi Hirano; Satoshi Yamaguchi; Akira Suzuki; Xin Guo; Nobuhiro Zaima; Ming Li; Kunihisa Kobayashi; Yoshihiko Ikeda; Toshiyuki Nakayama; Yasuyuki Sasaguri
    Histology and histopathology, Jan. 2021, Refereed
  • Characteristics and clinical outcomes in pituitary incidentalomas and non-incidental pituitary tumors treated with endoscopic transsphenoidal surgery.
    Yusuke Morinaga; Ichiro Abe; Kouhei Nii; Hayatsura Hanada; Yusuke Takemura; Yuichi Takashi; Kimiya Sakamoto; Ritsurou Inoue; Takafumi Mitsutake; Kunihisa Kobayashi; Toshio Higashi
    Medicine, 30 Oct. 2020, Refereed
  • Comprehensive Efficacy of the Dipeptidyl Peptidase 4 Inhibitor Alogliptin in Practical Clinical Settings: A Prospective Multi-Center Interventional Observational Study.
    Yosuke Takamiya; Kunihisa Kobayashi; Tadachika Kudo; Tetsu Okuda; Keisuke Okamura; Kazuyuki Shirai; Hidenori Urata
    Journal of clinical medicine research, Jul. 2020, Refereed
  • 甲状腺穿刺吸引細胞診後に生じた甲状腺腫大:救急外来における超音波検査が迅速な鑑別診断に有用であった前頸部腫脹の1例
    池田 悠悟; 阿部 一朗; 小林 邦久
    超音波医学, 01 Jan. 2020, Refereed
  • シックデイ対応マニュアルの作成およびそれを用いた服薬指導の重要性
    中島章雄; 松尾宏一; 宮崎元康; 内山将伸; 鵜木亜矢子; 後藤美和; 高木聡子; 三﨑桃子; 福江悠香; 中島千絵; 小林邦久; 今給黎修
    薬理と治療, 01 Jan. 2020, Refereed
  • Multicenter prospective observational study of teneligliptin, a selective dipeptidyl peptidase-4 inhibitor, in patients with poorly controlled type 2 diabetes: Focus on glycemic control, hypotensive effect, and safety Chikushi Anti-Diabetes Mellitus Trial-Teneligliptin (CHAT-T).
    Yosuke Takamiya; Keisuke Okamura; Kazuyuki Shirai; Tetsu Okuda; Kunihisa Kobayashi; Hidenori Urata
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2020
  • The Diagnostic Criteria 2020 for Triglyceride Deposit Cardiomyovasculopathy
    Kunihisa Kobayashi; Yasuhiko Sakata; Hideyuki Miyauchi; Yoshihiko Ikeda; Yasuyuki Nagasawa; Kenichi Nakajima; Kazunori Shimada; Junji Kozawa; Hiroyuki Hao; Tetsuya Amano; Hiroshi Yoshida; Tohru Inaba; Chikako Hashimoto; Ken-ichi Hirano; for the Japan TGCV; Study Group
    Annals of Nuclear Cardiology, 2020
  • A historical case of primary triglyceride deposit cardiomyovasculopathy.
    Michio Tanaka; Yoshihiko Ikeda; Ming Li; Nobuhiro Zaima; Yutaka Kawahara; Koji Watanabe; Tohru Inaba; Kunihisa Kobayashi; Hirotsugu Noguchi; Sohsuke Yamada; Hiroyuki Hao; Ken-Ichi Hirano
    Pathology international, Jan. 2020, Refereed
  • Effect of denosumab, a human monoclonal antibody of receptor activator of nuclear factor kappa-B ligand (RANKL), upon glycemic and metabolic parameters: Effect of denosumab on glycemic parameters.
    Ichiro Abe; Kentaro Ochi; Yuichi Takashi; Yuka Yamao; Hanako Ohishi; Hideyuki Fujii; Midori Minezaki; Kaoru Sugimoto; Tadachika Kudo; Makiko Abe; Yasushi Ohnishi; Shigeaki Mukoubara; Kunihisa Kobayashi
    Medicine, Nov. 2019, Refereed
  • Clinical investigation of pituitary incidentalomas: A two-center study.
    Kota Ishii; Ichiro Abe; Wataru Kameda; Kaoru Sugimoto; Yusuke Morinaga; Miiko Ito; Yuichi Takashi; Makiko Abe; Yurika Hada; Kaoru Takase; Hideyuki Fujii; Hanako Ohishi; Kentaro Ochi; Yuka Yamao; Midori Minezaki; Tadachika Kudo; Toshio Higashi; Yukihiko Sonoda; Kenichi Ishizawa; Kunihisa Kobayashi
    Intractable & rare diseases research, Nov. 2019, Refereed
  • 全身疾患と排便障害―内分泌疾患・糖尿病
    小林邦久
    臨床と研究, 31 Aug. 2019
  • DPP-4阻害薬 ~The First 10 Years~
    野見山崇; 小林邦久; 柳瀬敏彦; 浦田秀則
    日本体質医学会雑誌, 30 Jun. 2019, Refereed
  • Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder.
    Ming Li; Ken-Ichi Hirano; Yoshihiko Ikeda; Masahiro Higashi; Chikako Hashimoto; Bo Zhang; Junji Kozawa; Koichiro Sugimura; Hideyuki Miyauchi; Akira Suzuki; Yasuhiro Hara; Atsuko Takagi; Yasuyuki Ikeda; Kazuhiro Kobayashi; Yoshiaki Futsukaichi; Nobuhiro Zaima; Satoshi Yamaguchi; Rojeet Shrestha; Hiroshi Nakamura; Katsuhiro Kawaguchi; Eiryu Sai; Shu-Ping Hui; Yusuke Nakano; Akinori Sawamura; Tohru Inaba; Yasuhiko Sakata; Yoko Yasui; Yasuyuki Nagasawa; Shintaro Kinugawa; Kazunori Shimada; Sohsuke Yamada; Hiroyuki Hao; Daisaku Nakatani; Tomomi Ide; Tetsuya Amano; Hiroaki Naito; Hironori Nagasaka; Kunihisa Kobayashi
    Orphanet journal of rare diseases, 11 Jun. 2019, Refereed
  • Circular IRE-type RNAs of the NR5A1 gene are formed in adrenocortical cells.
    Kenji Ohe; Tomoko Tanaka; Yuta Horita; Yoshihiro Harada; Takafumi Yamasaki; Ichiro Abe; Makito Tanabe; Takashi Nomiyama; Kunihisa Kobayashi; Munechika Enjoji; Toshihiko Yanase
    Biochemical and biophysical research communications, 23 Apr. 2019, Refereed
  • Multicenter prospective observational study of teneligliptin, a selective dipeptidyl peptidase-4 inhibitor, in patients with poorly controlled type 2 diabetes
    Takamiya Y; Okamura K; Shirai K; Okuda T; Kobayashi K; Urata H
    Clin Exp Hypertens., 23 Apr. 2019, Refereed
  • Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma.
    Ichiro Abe; Hideyuki Fujii; Hanako Ohishi; Kaoru Sugimoto; Midori Minezaki; Midori Nakagawa; Saori Takahara; Tadachika Kudo; Makiko Abe; Kenji Ohe; Toshihiko Yanase; Kunihisa Kobayashi
    Endocrine journal, 28 Feb. 2019, Refereed
  • Potential Impact on Lipoprotein Subfractions in Type 2 Diabetes.
    Yuka Kamijo; Hideto Ishii; Tomohiko Yamamoto; Kunihisa Kobayashi; Hiroyuki Asano; Shunji Miake; Eiichiro Kanda; Hidenori Urata; Masayuki Yoshida
    Clinical medicine insights. Endocrinology and diabetes, 2019, Refereed
  • Investigation of efficacy and safety of low-dose sodium glucose transporter 2 inhibitors and differences between two agents, canagliflozin and ipragliflozin, in patients with type 2 diabetes mellitus.
    Kaoru Sugimoto; Ichiro Abe; Midori Minezaki; Yuichi Takashi; Kentaro Ochi; Hideyuki Fujii; Hanako Ohishi; Yuka Yamao; Tadachika Kudo; Kenji Ohe; Makiko Abe; Yasushi Ohnishi; Tomohiro Shinagawa; Shigeaki Mukoubara; Kunihisa Kobayashi
    Drug discoveries & therapeutics, 2019, Refereed
  • 高LDLコレステロール血症
    小林邦久
    臨床と研究, 01 Jan. 2019
  • Two cases of mitochondrial diabetes in which pancreatic beta-cell function and neuropathy were improved by glucagon-like peptide-1 receptor agonist therapy.
    Minezaki M; Abe I; Koga M; Sugimoto K; Takeshita K; Takahara S; Nakagawa M; Fujii H; Ohishi H; Kudo T; Ohe K; Yanase T; Kobayashi K
    Journal of Endocrinology and Metabolism, 01 Jan. 2019, Refereed
  • Clinical Investigation of Adrenal Incidentalomas in Japanese Patients of the Fukuoka Region with Updated Diagnostic Criteria for Sub-clinical Cushing's Syndrome.
    Ichiro Abe; Kaoru Sugimoto; Tetsumasa Miyajima; Tomoko Ide; Midori Minezaki; Kaori Takeshita; Saori Takahara; Midori Nakagawa; Yuki Fujimura; Tadachika Kudo; Shigero Miyajima; Hiroshi Taira; Kenji Ohe; Tatsu Ishii; Toshihiko Yanase; Kunihisa Kobayashi
    Internal medicine (Tokyo, Japan), 01 Sep. 2018, Refereed
  • HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells.
    Kenji Ohe; Shinsuke Miyajima; Ichiro Abe; Tomoko Tanaka; Yuriko Hamaguchi; Yoshihiro Harada; Yuta Horita; Yuki Beppu; Fumiaki Ito; Takafumi Yamasaki; Hiroki Terai; Masayoshi Mori; Yusuke Murata; Makito Tanabe; Kenji Ashida; Kunihisa Kobayashi; Munechika Enjoji; Toshihiko Yanase; Nobuhiro Harada; Toshiaki Utsumi; Akila Mayeda
    The Journal of steroid biochemistry and molecular biology, Sep. 2018, Refereed
  • Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy.
    Akira Suzuki; Satoshi Yamaguchi; Ming Li; Yasuhiro Hara; Hideyuki Miyauchi; Yoshihiko Ikeda; Bo Zhang; Masahiro Higashi; Yasuyuki Ikeda; Atsuko Takagi; Hironori Nagasaka; Kunihisa Kobayashi; Yasuhiro Magata; Toshiaki Aoyama; Ken-Ichi Hirano
    Journal of oleo science, 01 Aug. 2018, Refereed
  • Definitive diagnosis of mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome caused by a recurrent de novo mutation in the POLD1 gene.
    Haruka Sasaki; Kumiko Yanagi; Satoshi Ugi; Kunihisa Kobayashi; Kumiko Ohkubo; Yuji Tajiri; Hiroshi Maegawa; Atsunori Kashiwagi; Tadashi Kaname
    Endocrine journal, 26 Feb. 2018, Refereed
  • Diagnostic Criteria and Severity Score for Triglyceride Deposit Cardiomyovasculopathy
    Hideyuki Miyauchi; Chikako Hashimoto; Yoshihiko Ikeda; Ming Li; Yusuke Nakano; Junji Kozawa; Eiryu Sai; Yasuyuki Nagasawa; Koichiro Sugimura; Shintaro Kinugawa; Katsuhiro Kawaguchi; Kazunori Shimada; Tomomi Ide; Tetsuya Amano; Masahiro Higashi; Tohru Inaba; Hiroshi Nakamura; Kunihisa Kobayashi; Ken-ichi Hirano
    Annals of Nuclear Cardiology, 2018
  • Persistent Primary Aldosteronism Despite Iatrogenic Adrenal Hemorrhage After Adrenal Vein Sampling.
    Keisuke Okamura; Tetsu Okuda; Kazuyuki Shirai; Ichiro Abe; Kunihisa Kobayashi; Tatsu Ishii; Seiji Haraoka; Hidenori Urata
    Journal of clinical medicine research, Jan. 2018
  • Newly developed selective immunoinactivation assay revealed reduction in adipose triglyceride lipase activity in peripheral leucocytes from patients with idiopathic triglyceride deposit cardiomyovasculopathy.
    Atsuko Takagi; Yasuyuki Ikeda; Kunihisa Kobayashi; Kazuhiro Kobayashi; Yoshihiko Ikeda; Junji Kozawa; Hideyuki Miyauchi; Ming Li; Chikako Hashimoto; Yasuhiro Hara; Satoshi Yamaguchi; Akira Suzuki; Tatsushi Toda; Hironori Nagasaka; Ken-Ichi Hirano
    Biochemical and biophysical research communications, 01 Jan. 2018
  • Investigation of metabolic and circulatory parameters that predict effects of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, on blood glucose and body weight in a retrospective, multicenter study
    Kudo T; Abe I; Minezaki M; Sugimoto K; Fujii H; Ohishi H; Nakagawa M; Yano S; Matsubayashi S; Fukudome M; Ninomiya H; Ishii H; Kodera T; Ito H; Maeda Y; Kobayashi K
    J Diabetes Metab, 2018, Refereed
  • HMGA1a Induces Alternative Splicing of the Estrogen Receptor-αlpha Gene by Trapping U1 snRNP to an Upstream Pseudo-5' Splice Site.
    Kenji Ohe; Shinsuke Miyajima; Tomoko Tanaka; Yuriko Hamaguchi; Yoshihiro Harada; Yuta Horita; Yuki Beppu; Fumiaki Ito; Takafumi Yamasaki; Hiroki Terai; Masayoshi Mori; Yusuke Murata; Makito Tanabe; Ichiro Abe; Kenji Ashida; Kunihisa Kobayashi; Munechika Enjoji; Takashi Nomiyama; Toshihiko Yanase; Nobuhiro Harada; Toshiaki Utsumi; Akila Mayeda
    Frontiers in molecular biosciences, 2018, Refereed
  • The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study
    Hiroshi Nitta; Sayaka Katagiri; Toshiyuki Nagasawa; Yuichi Izumi; Isao Ishikawa; Hajime Izumiyama; Isao Uchimura; Masao Kanazawa; Hiroshige Chiba; Akira Matsuo; Kazunori Utsunomiya; Haruyasu Tanabe; Izumi Takei; Soichiro Asanami; Hiroshi Kajio; Toaki Ono; Yoichi Hayashi; Kiichi Ueki; Masatomi Tsuji; Yoichi Kurachi; Toshikazu Yamanouchi; Yoshimi Ichinokawa; Toshiki Inokuchi; Akiko Fukui; Shigeru Miyazaki; Takashi Miyauchi; Reiko Kawahara; Hideki Ogiuchi; Narihito Yoshioka; Jun Negishi; Masatomo Mori; Kenji Mogi; Yasushi Saito; Hideki Tanzawa; Tetsuo Nishikawa; Norihiko Takada; Kishio Nanjo; Nobuo Morita; Naoto Nakamura; Narisato Kanamura; Hirofumi Makino; Fusanori Nishimura; Kunihisa Kobayashi; Yoshinori Higuchi; Toshiie Sakata; Shigetaka Yanagisawa; Chuwa Tei; Yuichi Ando; Nobuhiro Hanada; Shuji Inoue
    JOURNAL OF DIABETES INVESTIGATION, Sep. 2017, Refereed
  • Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy
    Higashi Masahiro; Ikeda Yoshihiko; Miyauchi Hideyuki; Zaima Nobuhiro; Suzuki Akira; Li Ming; Kobayashi Kunihisa; Naito Hiroaki; Hirano Ken-ichi
    Annals of Nuclear Cardiology, 2017
  • Novel subtype of congenital partial lipodystrophy with mandibular hypoplasia, sensorineural deafness and short stature of unknown genetic origin
    Haruka Sasaki; Kumiko Ohkubo; Kunihisa Kobayashi; Yuji Tajiri; Satoshi Ugi; Atsunori Kashwagi
    J Diabetes Investig, 2017, Refereed
  • 16年間に慢性甲状腺炎・自己免疫性肝炎・緩徐進行1型糖尿病・全身性エリテマトーデスを発症した1例
    Yanagita Ikumi; Kamiya Akiko; Sugimoto Kaoru; Noda Tomohiro; Nagasako Hisahiro; Noma Eijiro; Haraoka Seiji; Maruoka Hiroshi; Sugimura Takashi; Kodera Takehiko; Abe Ichiro; Kudo Tadachika; Kobayashi Kunihisa
    Journal of the Japan Diabetes Society, 2016, Refereed
  • Efficacy and safety of low-dose ipragliflozin, a selective sodium glucose transporter 2 inhibitor, in patients with type 2 diabetes mellitus
    Abe, I; Ohnishi Y; Koga M; Sugimoto K; Kudo T; Kobayashi K; Mukobara S
    Int J of Allied Med Sci and Clin Res., 2016, Refereed
  • Hyperinsulinemia and sulfonylurea use are independently associated with left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus with suboptimal blood glucose control.
    Inoue T; Maeda Y; Sonoda N; Sasaki S; Kabemura T; Kobayashi K; Inoguchi T
    BMJ Open Diabetes Res Care, 2016, Refereed
  • Distinct cardiac phenotype between two homozygotes born in a village with accumulation of a genetic deficiency of adipose triglyceride lipase
    Masahiro Higashi; Ken-ichi Hirano; Kazuhiro Kobayashi; Yoshihiko Ikeda; Ami Issiki; Tetsuo Otsuka; Akira Suzuki; Satoshi Yamaguchi; Nobuhiro Zaima; Seiki Hamada; Hironori Hanada; Chieko Suzuki; Hiroshi Nakamura; Hironori Nagasaka; Toshiyuki Miyata; Yoshihiro Miyamoto; Kunihisa Kobayashi; Hiroaki Naito; Tatsushi Toda
    INTERNATIONAL JOURNAL OF CARDIOLOGY, Aug. 2015, Refereed
  • Efficacy of dipeptidyl peptidase-4 inhibitor linagliptin in patients with type 2 diabetes undergoing hemodialysis
    Yuichi Terawaki; Takashi Nomiyama; Hiroyuki Takahashi; Yoko Tsutsumi; Kunitaka Murase; Ryoko Nagaishi; Makito Tanabe; Tadachika Kudo; Kunihisa Kobayashi; Tetsuhiko Yasuno; Hitoshi Nakashima; Toshihiko Yanase
    DIABETOLOGY & METABOLIC SYNDROME, May 2015, Refereed
  • Predictive Approaches for Low-Cost Preventive Medicine Program in Developing Countries
    Yukino Baba; Tatsuo Hiramatsu; Michio Kimura; Shuji Shimizu; Kunihisa Kobayashi; Koji Tsuda; Masashi Sugiyama; Mathieu Blondel; Naonori Ueda; Masaru Kitsuregawa; Naoki Nakashima; Hisashi Kashima; Yasunobu Nohara; Eiko Kai; Partha Ghosh; Rafiqul Islam; Ashir Ahmed; Masahiro Kuroda; Sozo Inoue
    Proceedings of the 21th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining - KDD '15, 2015
  • Complete remission of anaplastic thyroid carcinoma after concomitant treatment with docetaxel and radiotherapy.
    Abe I; Karasaki S; Matsuda Y; Sakamoto S; Nakashima T; Yamamoto H; Kawate H; Ohnaka K; Nakashima H; Kobayashi K; Oda Y; Nomura M; Takayanagi R
    Case Rep Endocrinol., 2015, Refereed
  • Health Checkup and Telemedical Intervention Program for Preventive Medicine in Developing Countries: Verification Study
    Yasunobu Nohara; Eiko Kai; Partha Pratim Ghosh; Rafiqul Islam; Ashir Ahmed; Masahiro Kuroda; Sozo Inoue; Tatsuo Hiramatsu; Michio Kimura; Shuji Shimizu; Kunihisa Kobayashi; Yukino Baba; Hisashi Kashima; Koji Tsuda; Masashi Sugiyama; Mathieu Blondel; Naonori Ueda; Masaru Kitsuregawa; Naoki Nakashima
    JOURNAL OF MEDICAL INTERNET RESEARCH, Jan. 2015, Refereed
  • Coronary triglyceride deposition in contemporary advanced diabetics
    Yoshihiko Ikeda; Nobuhiro Zaima; Ken-ichi Hirano; Masayuki Mano; Kunihisa Kobayashi; Sohsuke Yamada; Satoshi Yamaguchi; Akira Suzuki; Hideaki Kanzaki; Toshimitsu Hamasaki; Jun-ichi Kotani; Seiya Kato; Hironori Nagasaka; Mitsutoshi Setou; Hatsue Ishibashi-Ueda
    PATHOLOGY INTERNATIONAL, Jul. 2014, Refereed
  • Genetic mutations in adipose triglyceride lipase and myocardial up-regulation of peroxisome proliferated activated receptor-gamma in patients with triglyceride deposit cardiomyovasculopathy
    Ken-ichi Hirano; Tatsuya Tanaka; Yoshihiko Ikeda; Satoshi Yamaguchi; Nobuhiro Zaima; Kazuhiro Kobayashi; Akira Suzuki; Yasuhiko Sakata; Yasushi Sakata; Kunihisa Kobayashi; Tatsushi Toda; Norihide Fukushima; Hatsue Ishibashi-Ueda; Daniela Tavian; Hironori Nagasaka; Shu-Ping Hui; Hitoshi Chiba; Yoshiki Sawa; Masatsugu Hori
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2014, Refereed
  • Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice
    Tomoaki Inoue; Kunihisa Kobayashi; Toyoshi Inoguchi; Noriyuki Sonoda; Yasutaka Maeda; Eiichi Hirata; Yoshinori Fujimura; Daisuke Miura; Ken-ichi Hirano; Ryoichi Takayanagi
    Biochemical and Biophysical Research Communications, 16 Aug. 2013, Refereed
  • CTLA-4Ig immunotherapy of obesity-induced insulin resistance by manipulation of macrophage polarization in adipose tissues
    Masakazu Fujii; Toyoshi Inoguchi; Battsetseg Batchuluun; Naonobu Sugiyama; Kunihisa Kobayashi; Noriyuki Sonoda; Ryoichi Takayanagi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2013, Refereed
  • Evaluation of "Portable Health Clinic" with BAN standard for 10K subjects in Bangladesh
    Naoki Nakashima; Tatsuo Hiramatsu; Partha Pratim Ghosh; Rafiqul Islam; Kunihisa Kobayashi; Toyoshi Inoguchi
    2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), Jul. 2013, Refereed
  • An Affordable, Usable and Sustainable Preventive Healthcare System for Unreached People in Bangladesh.
    Naoki Nakashima; Yasunobu Nohara; Ashir Ahmed; Masahiro Kuroda; Sozo Inoue; Partha Pratim Ghosh; Rafiqul Islam Maruf; Tatsuo Hiramatsu; Kunihisa Kobayashi; Toyoshi Inoguchi; Masaru Kitsuregawa
    MEDINFO 2013 - Proceedings of the 14th World Congress on Medical and Health Informatics(MedInfo), 2013
  • Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress
    Jing Zheng; Toyoshi Inoguchi; Shuji Sasaki; Yasutaka Maeda; Mark F. McCarty; Masakazu Fujii; Noriko Ikeda; Kunihisa Kobayashi; Noriyuki Sonoda; Ryoichi Takayanagi
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Jan. 2013, Refereed
  • Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4-associated oxidative stress in diabetic hamsters
    Yasutaka Maeda; Toyoshi Inoguchi; Ryoko Takei; Hari Hendarto; Makoto Ide; Tomoaki Inoue; Kunihisa Kobayashi; Hidenori Urata; Akira Nishiyama; Ryoichi Takayanagi
    JOURNAL OF DIABETES INVESTIGATION, Aug. 2012
  • 2型糖尿病関連中性脂肪蓄積心筋血管症
    平野 賢一; 池田 善彦; 財満 信宏; 眞能 正幸; 小林 邦久; 神崎 秀明; 加藤 誠也; 笹栗 靖之; 友池 仁暢; 瀬藤 光利; 植田 初江
    日本病理学会会誌, Mar. 2012
  • 我が国で見いだされた新規疾患単位、中性脂肪蓄積心筋血管症 希少難病からcommon diseaseへの展開
    平野 賢一; 財満 信宏; 池田 善彦; 眞能 正幸; 小林 邦久; 神崎 秀明; 北風 政史; 小室 一成; 瀬藤 光利; 友池 仁暢
    日本内科学会雑誌, Feb. 2012
  • A case report of type 2 diabetes mellitus with biatrial thrombi and pulmonary embolism caused by atrial fibrillation: Successful treatment with anticoagulant therapy
    Tomoaki Inoue; Kunihisa Kobayashi; Takefumi Katsuragi; Isao Ichino; Seiichi Tanaka; Masafumi Haji; Toyoshi Inoguchi; Ryoichi Takayanagi
    Diabetology International, Dec. 2011, Refereed
  • Reduced Expression of Adipose Triglyceride Lipase Enhances Tumor Necrosis Factor alpha-induced Intercellular Adhesion Molecule-1 Expression in Human Aortic Endothelial Cells via Protein Kinase C-dependent Activation of Nuclear Factor-kappa B
    Tomoaki Inoue; Kunihisa Kobayashi; Toyoshi Inoguchi; Noriyuki Sonoda; Masakazu Fujii; Yasutaka Maeda; Yoshinori Fujimura; Daisuke Miura; Ken-ichi Hirano; Ryoichi Takayanagi
    JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2011, Refereed
  • Biliverdin protects against the deterioration of glucose tolerance in db/db mice
    N. Ikeda; T. Inoguchi; N. Sonoda; M. Fujii; R. Takei; E. Hirata; H. Yokomizo; J. Zheng; Y. Maeda; K. Kobayashi; R. Takayanagi
    DIABETOLOGIA, Aug. 2011, Refereed
  • Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters
    Yasutaka Maeda; Toyoshi Inoguchi; Ryoko Takei; Fumi Sawada; Shuji Sasaki; Masakazu Fujii; Kunihisa Kobayashi; Hidenori Urata; Akira Nishiyama; Ryoichi Takayanagi
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, Dec. 2010
  • Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase
    Masakazu Fujii; Toyoshi Inoguchi; Shuji Sasaki; Yasutaka Maeda; Jing Zheng; Kunihisa Kobayashi; Ryoichi Takayanagi
    KIDNEY INTERNATIONAL, Nov. 2010, Refereed
  • 粟粒結核に血球貪食症候群・播種性血管内凝固症候群・成人呼吸窮迫症候群・急性腎不全を合併した糖尿病患者の一例
    井上智彰; 葛城武文; 國本政瑞沖; 市野 功; 田中誠一; 濱田哲夫; 小林邦久; 土師正文; 井口登與志; ?涼一
    糖尿病, Apr. 2010, Refereed
  • A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins
    Keiko Sakai; Oliver Tiebel; M. Cecilia Ljungberg; Merry Sullivan; Hye-Jeong Lee; Tomoya Terashima; Ronying Li; Kunihisa Kobayashi; Hui-Chen Lu; Lawrence Chan; Kazuhiro Oka
    BRAIN RESEARCH, Jun. 2009
  • Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic beta-cell line, MIN6
    Fumi Sawada; Toyoshi Inoguchi; Hirotaka Tsubouchi; Shuji Sasaki; Masakazu Fujii; Yasutaka Maeda; Hidetaka Morinaga; Masatoshi Nomura; Kunihisa Kobayashi; Ryoichi Takayanagi
    METABOLISM-CLINICAL AND EXPERIMENTAL, Aug. 2008
  • The lack of the C-terminal domain of adipose triglyceride lipase causes neutral lipid storage disease through impaired interactions with lipid droplets
    Kunihisa Kobayashi; Toyoshi Inoguchi; Yasutaka Maeda; Naoki Nakashima; Asako Kuwano; Erina Eto; Noriko Ueno; Shuji Sasaki; Fumi Sawada; Masakazu Fujii; Yuka Matoba; Shinji Sumiyoshi; Hisaya Kawate; Ryoichi Takayanagi
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Jul. 2008, Refereed
  • Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes
    Toyoshi Inoguchi; Shuji Sasaki; Kunihisa Kobayashi; Ryoichi Takayanagi; Tomomi Yamada
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Sep. 2007
  • Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice
    M. Fujii; T. Inoguchi; Y. Maeda; S. Sasaki; F. Sawada; R. Saito; K. Kobayashi; H. Sumimoto; R. Takayanagi
    KIDNEY INTERNATIONAL, Aug. 2007
  • Gastric emptying in diabetic patients by the C-13-octanoic acid breath test: role of insulin in gastric motility
    Masahiro Matsumoto; Rie Yoshimura; Hirotada Akiho; Naomi Higuchi; Kunihisa Kobayashi; Noriaki Matsui; Kentaro Taki; Hiroyuki Murao; Haruei Ogino; Kenji Kanayama; Yorinobu Sumida; Takahiro Mizutani; Kuniomi Honda; Shigetaka Yoshinaga; Soichi Itaba; Hiromi Muta; Naohiko Harada; Kazuhiko Nakamura; Ryoichi Takayanagi
    JOURNAL OF GASTROENTEROLOGY, Jun. 2007
  • Molecular mechanisms of the antiatherogenic action of adiponectin
    Kunihisa Kobayashi; Toyoshi Inoguchi
    Vascular Disease Prevention, Feb. 2007
  • A Japanese Model of Disease Management
    Naoki Nakashima; Kunihisa Kobayashi; Toyoshi Inoguchi; Daisuke Nishida; Naomi Tanaka; Hiromi Nakazono; Akihiko Hoshino; Hidehisa Soejima; Ryoichi Takayanagi; Hajime Nawata
    MEDINFO 2007: PROCEEDINGS OF THE 12TH WORLD CONGRESS ON HEALTH (MEDICAL) INFORMATICS, PTS 1 AND 2, 2007
  • Therapeutic angiogenesis by ex vivo expanded erythroid progenitor cells
    Shuji Sasaki; Toyoshi Inoguchi; Koichiro Muta; Yasunobu Abe; Min Zhang; Kenichi Hiasa; Kensuke Egashira; Noriyuki Sonoda; Kunihisa Kobayashi; Ryoichi Takayanagi; Hajime Nawata
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Jan. 2007
  • 糖尿病疾病管理のための地域医療連携クリティカルパスの開発
    小林邦久; 中島直樹; 井口登與志; 西田大介; 田中直美; 星乃明彦; 濱田倫朗; 小妻幸男; 中熊英貴; 松下龍之介; 副島秀久; 髙栁涼一; 名和田新
    糖尿病, 2006, Refereed
  • Adipose differentiation related protein induces lipid accumulation and lipid droplet formation in hepatic stellate cells
    M Fukushima; M Enjoji; M Kohjima; R Sugimoto; S Ohta; K Kotoh; M Kuniyoshi; K Kobayashi; M Imamura; T Inoguchi; M Nakamuta; H Nawata
    IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, Nov. 2005
  • Adiponectin inhibits the binding of low-density lipoprotein to biglycan, a vascular proteoglycan
    K Kobayashi; T Inoguchi; N Sonoda; N Sekiguchi; H Nawata
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2005
  • Erythropoietin attenuated high glucose-induced apoptosis in cultured human aortic endothelial cells
    Naotaka Sekiguchi; Toyoshi Inoguchi; Kunihisa Kobayashi; Noriyuki Sonoda; Hajime Nawata
    Biochemical and Biophysical Research Communications, 19 Aug. 2005, Refereed
  • Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement
    H Tsubouchi; T Inoguchi; T Sonta; N Sato; N Sekiguchi; K Kobayashi; H Sumimoto; H Utsumi; H Nawata
    FREE RADICAL BIOLOGY AND MEDICINE, Aug. 2005
  • Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist
    M Nakayama; T Inoguchi; T Sonta; Y Maeda; S Sasaki; F Sawada; H Tsubouchi; N Sonoda; K Kobayashi; H Sumimoto; H Nawata
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2005
  • Adipokines: Therapeutic targets for metabolic syndrome
    K Kobayashi; T Inoguchi
    CURRENT DRUG TARGETS, Jun. 2005
  • In vivo imaging of oxidative stress in the kidney of diabetic mice and its normalization by angiotensin II type 1 receptor blocker
    T Sonta; T Inoguchi; S Matsumoto; K Yasukawa; M Inuo; H Tsubouchi; N Sonoda; K Kobayashi; H Utsumi; H Nawata
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2005
  • Adenovirus-mediated high expression of resistin causes dyslipidemia in mice
    N Sato; K Kobayashi; T Inoguchi; N Sonoda; M Imamura; N Sekiguchi; N Nakashima; H Nawata
    ENDOCRINOLOGY, Jan. 2005
  • Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic β-cell line, MIN6?a role of NAD(P)H oxidase in β-cells.
    Hirotaka Tsubouchi; Toyoshi Inoguchi; Mieko Inuo; Maiko Kakimoto; Toshiyo Sonta; Noriyuki Sonoda; Shuji Sasaki; Kunihisa Kobayashi; Hideki Sumimoto; Hajime Nawata
    Biochemical and Biophysical Research Communications, 31 Dec. 2004
  • Evalution of oxidative stress in diabetic animals by in vivo electron spin resonance measurement - Role of protein kinase C
    Toshiyo Sonta; Toyoshi Inoguchi; Hirotaka Tsubouchi; Naotaka Sekiguchi; Kunihisa Kobayashi; Shingo Matsumoto; Hideo Utsumi; Hajime Nawata
    Diabetes Research and Clinical Practice, Dec. 2004
  • Evalution of oxidative stress in diabetic animals by in vivo electron spin resonance measurement--role of protein kinase C.
    Toshiyo Sonta; Toyoshi Inoguchi; Hirotaka Tsubouchi; Naotaka Sekiguchi; Kunihisa Kobayashi; Shingo Matsumoto; Hideo Utsumi; Hajime Nawata
    Diabetes research and clinical practice, Dec. 2004
  • Effect of erythropoietin on endothelial cell apoptosis induced by high glucose
    Naotaka Sekiguchi; Toyoshi Inoguchi; Kunihisa Kobayashi; Hajime Nawata
    Diabetes Research and Clinical Practice, Dec. 2004, Refereed
  • Evidence for contribution of vascular Nad(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity
    T Sonta; T Inoguchi; H Tsubouchi; N Sekiguchi; K Kobayashi; S Matsumoto; H Utsumi; H Nawata
    FREE RADICAL BIOLOGY AND MEDICINE, Jul. 2004
  • Resistin: A matter of mice and men
    Kunihisa Kobayashi; Toyoshi Inoguchi; Hajime Nawata
    Recent Res. Devel. Physiol., 2004
  • Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment
    T Etoh; T Inoguchi; M Kakimoto; N Sonoda; K Kobayashi; J Kuroda; H Sumimoto; H Nawata
    DIABETOLOGIA, Oct. 2003
  • Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase.
    Toyoshi Inoguchi; Toshiyo Sonta; Hirotaka Tsubouchi; Takashi Etoh; Maiko Kakimoto; Noriyuki Sonoda; Naoichi Sato; Naotaka Sekiguchi; Kunihisa Kobayashi; Hideki Sumimoto; Hideo Utsumi; Hajime Nawata
    Journal of the American Society of Nephrology : JASN, Aug. 2003
  • A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidase
    Toyoshi Inoguchi; H. Tsubouchi; T. Etoh; M. Kakimoto; T. Sonta; H. Utsumi; H. Sumimoto; H. Y. Yu; N. Sonoda; M. Inuo; N. Sato; N. Sekiguchi; K. Kobayashi; H. Nawata
    Current Medicinal Chemistry, 2003
  • ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts
    M Imamura; T Inoguchi; S Ikuyama; S Taniguchi; K Kobayashi; N Nakashima; H Nawata
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Oct. 2002
  • A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing
    PP Lau; H Villanueva; K Kobayashi; M Nakamuta; BHJ Chang; L Chan
    JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2001
  • Gene therapy for diabetic dyslipidemia
    Therapeutic Research, 2000
  • The db/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of Western diet feeding
    K Kobayashi; TM Forte; S Taniguchi; BY Ishida; K Oka; L Chan
    METABOLISM-CLINICAL AND EXPERIMENTAL, Jan. 2000, Refereed
  • Adenovirus-mediated human Topoisomerase II alpha gene transfer increases the sensitivity of etoposide-resistant human breast cancer cells
    ZC Zhou; LA Zwelling; Y Kawakami; TH An; K Kobayashi; C Herzog; ES Kleinerman
    CANCER RESEARCH, Sep. 1999
  • Adenovirus-mediated overexpression of microsomal triglyceride transfer protein (MTP): Mechanistic studies on the role of MTP in apolipoprotein B-100 biogenesis
    W Liao; K Kobayashi; L Chan
    BIOCHEMISTRY, Jun. 1999
  • Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor
    MC Jong; KW Van Dijk; VEH Dahlmans; H Van der Boom; K Kobayashi; K Oka; G Siest; L Chan; MH Hofker; LM Havekes
    BIOCHEMICAL JOURNAL, Mar. 1999
  • Resistance of chylomicron and VLDL remnants to postheparin lipolysis in ApoE-deficient mice: the role of apoE in lipoprotein lipase-mediated lipolysis in vivo and in vitro
    E Zsigmond; Y Fuke; L Li; K Kobayashi; L Chan
    JOURNAL OF LIPID RESEARCH, Sep. 1998
  • Phenotype interaction of apobec-1 and CETP, LDLR, and ApoE gene expression in mice - Role of ApoB mRNA editing in lipoprotein phenotype expression
    M Nakamuta; S Taniguchi; BY Ishida; K Kobayashi; L Chan
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, May 1998
  • Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor
    KW van Dijk; BJM van Vlijmen; A van der Zee; B van't Hof; H van der Boom; K Kobayashi; L Chan; LM Havekes; MH Hofker
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Jan. 1998
  • Production of rabbit polyclonal antibody against apobec-1 by genetic immunization
    SCJ Yeung; J Anderson; K Kobayashi; K Oka; L Chan
    JOURNAL OF LIPID RESEARCH, Dec. 1997
  • Adenovirus-mediated gene transfer of human lipoprotein lipase ameliorates the hyperlipidemias associated with apolipoprotein E and LDL receptor deficiencies in mice
    E Zsigmond; K Kobayashi; KW Tzung; L Li; Y Fuke; L Chan
    HUMAN GENE THERAPY, Nov. 1997
  • Molecular basis and promise of genetic therapy for diabetic dyslipidaemia: Studies in an animal model of diabetes
    L Chan; K Kobayashi
    DIABETOLOGIA, Jul. 1997
  • Molecular basis and promise of genetic therapy for diabetic dyslipidaemia: Studies in an animal model of diabetes
    L Chan; K Kobayashi
    DIABETOLOGIA, Jul. 1997
  • Effect of beraprost sodium on the increased transendothelial permeation of albumin induced by high concentration of glucose
    K. Kobayashi; F. Umeda; T. Hashimoto; K. Mimura; T. Yamashita; H. Nawata
    Fukuoka Acta Medica, 1997
  • Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice
    K Oka; K Kobayashi; M Sullivan; J Martinez; BB Teng; K IshimuraOka; L Chan
    JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 1997
  • Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic: Background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of apobec-1
    M Nakamuta; BHJ Chang; E Zsigmond; K Kobayashi; H Lei; BY Ishida; K Oka; E Li; L Chan
    JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1996
  • Dehydroepiandrosterone markedly inhibits the accumulation of cholesteryl ester in mouse macrophage J774-1 cells
    S Taniguchi; T Yanase; K Kobayashi; R Takayanagi; H Nawata
    ATHEROSCLEROSIS, Sep. 1996
  • Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor
    K Kobayashi; K Oka; T Forte; B Ishida; BB Teng; K IshimuraOka; M Nakamuta; L Chan
    JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1996
  • Insulin resistance and atherosclerosis in non-insulin-dependent diabetes mellitus
    Therapeutic Research, 1996
  • EFFECTS OF GLUCOSE AND AN ALDOSE REDUCTASE INHIBITOR ON ALBUMIN PERMEATION THROUGH A LAYER OF CULTURED BOVINE VASCULAR ENDOTHELIAL-CELLS
    K MIMURA; F UMEDA; T YAMASHITA; K KOBAYASHI; T HOSHIMOTO; H NAWATA
    HORMONE AND METABOLIC RESEARCH, Oct. 1995
  • METABOLISM OF OXIDIZED GLYCATED LOW-DENSITY-LIPOPROTEIN IN CULTURED BOVINE AORTIC ENDOTHELIAL-CELLS
    K KOBAYASHI; J WATANABE; F UMEDA; M MASAKADO; Y ONO; S TANIGUCHI; T YANASE; T HASHIMOTO; Y SAKO; H NAWATA
    HORMONE AND METABOLIC RESEARCH, Aug. 1995
  • GLYCATION ACCELERATES THE OXIDATION OF LOW-DENSITY-LIPOPROTEIN BY COPPER IONS
    K KOBAYASHI; J WATANABE; F UMEDA; H NAWATA
    ENDOCRINE JOURNAL, Aug. 1995
  • INCREASED TRANSENDOTHELIAL PERMEATION OF ALBUMIN BY HIGH GLUCOSE-CONCENTRATION
    T YAMASHITA; K MIMURA; F UMEDA; K KOBAYASHI; T HASHIMOTO; H NAWATA
    METABOLISM-CLINICAL AND EXPERIMENTAL, Jun. 1995
  • ALTERNATIVE MESSENGER-RNA SPLICING AND DIFFERENTIAL PROMOTER UTILIZATION DETERMINE TISSUE-SPECIFIC EXPRESSION OF THE APOLIPOPROTEIN-B MESSENGER-RNA-EDITING PROTEIN (APOBEC1) GENE IN MICE - STRUCTURE AND EVOLUTION OF APOBEC1 AND RELATED NUCLEOSIDE NUCLEOTIDE DEAMINASES
    M NAKAMUTA; K OKA; J KRUSHKAL; K KOBAYASHI; M YAMAMOTO; WH LI; L CHAN
    JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1995
  • ENHANCEMENT OF PROSTACYCLIN PRODUCTION IN CULTURED BOVINE AORTIC ENDOTHELIAL-CELLS BY OXIDIZED GLYCATED LOW-DENSITY-LIPOPROTEIN
    K KOBAYASHI; J WATANABE; F UMEDA; S TANIGUCHI; M MASAKADO; T YAMAUCHI; H NAWATA
    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, Apr. 1995
  • CATECHOL ESTROGENS ARE MORE POTENT ANTIOXIDANTS THAN ESTROGENS FOR THE CU2+-CATALYZED OXIDATION OF LOW OR HIGH-DENSITY-LIPOPROTEIN - ANTIOXIDATIVE EFFECTS OF STEROIDS ON LIPOPROTEINS
    S TANIGUCHI; T YANASE; K KOBAYASHI; R TAKAYANAGI; M HAJI; F UMEDA; H NAWATA
    ENDOCRINE JOURNAL, Dec. 1994
  • APOLIPOPROTEIN-E POLYMORPHISM AFFECTS THE RESPONSE TO PRAVASTATIN ON PLASMA APOLIPOPROTEINS IN DIABETIC-PATIENTS
    J WATANABE; K KOBAYASHI; F UMEDA; T YAMAUCHI; K MIMURA; N NAKASHIMA; M MASAKADO; S HIRAMATSU; H NAWATA
    DIABETES RESEARCH AND CLINICAL PRACTICE, Apr. 1993
  • A case report of diabetic nephropathy treated with recombinant human erythropoietin.
    Rinsho to Kenkyu, 1991
■ MISC
  • 【『DM Ensemble』10年の振り返りと新創刊に向けて】
    小林 邦久; 稲垣 美智子; 堀川 幸男; 亀山 亜希夫; 本田 寛人; 高野 直久; 脇 裕典
    DM Ensemble, Nov. 2022
  • 7腎症重症化予防のために 糖尿病医の立場から
    小林 邦久
    筑紫, Sep. 2022
  • 糖尿病患者の心臓拡張機能に影響を与える因子の検討
    井上 智彰; 井口 登與志; 小林 邦久; 園田 紀之; 前野 彩香; 佐々木 修二; 高柳 涼一
    糖尿病, Aug. 2015
  • 糖尿病患者の心臓拡張機能に影響を与える因子の検討
    前野 彩香; 井上 智彰; 井口 登與志; 小林 邦久; 園田 紀之; 佐々木 修二; 高柳 涼一
    糖尿病, Apr. 2015
  • 両心房内巨大血栓および肺塞栓症をきたした心房細動合併2型糖尿病の一例
    井上 智彰; 市野 功; 田中 誠一; 小林 邦久; 土師 正文; 井口 登與志; 高柳 涼一
    糖尿病, Jul. 2011
  • 藻類スピルリナより精製したフィコシアニンとフィコシアノビリンの糖尿病性腎症改善効果の検討
    鄭 静; 井口 登與志; 藤井 雅一; 前田 泰孝; 池田 紀子; 武井 涼子; 平田 英一; 横溝 久; 佐藤 美紀子; 小林 邦久; 高柳 涼一
    Diabetes Frontier, Oct. 2010
  • 粟粒結核に血球貪食症候群・DIC・ARDS・急性腎不全を合併した糖尿病患者の1例
    井上 智彰; 葛城 武文; 國本 政瑞沖; 市野 功; 田中 誠一; 渡辺 秀幸; 濱田 哲夫; 小林 邦久; 土師 正文; 井口 登與志; 高柳 涼一
    糖尿病, Apr. 2010
  • 全身性中性脂肪蓄積症におけるATGL遺伝子変異と細胞内局在
    小林 邦久; 井上 智彰; 前田 泰孝; 佐藤 美紀子; 井手 誠; 武井 涼子; 藤井 雅一; 中島 直樹; 井口 登與志; 高柳 涼一
    糖尿病, Apr. 2010
  • 脂肪滴関連蛋白Adipose Differentiation-related Protein(ADRP)トランスジェニックマウスの解析(第3報)
    園田 紀之; 小林 邦久; 今村 美菜子; 鄭 静; 前田 泰孝; 澤田 布美; 佐々木 修二; 中山 三枝子; 西藤 亮子; 森永 秀孝; 野村 政壽; 谷口 晋; 生山 祥一郎; 名和田 新; 井口 登與志
    糖尿病, Apr. 2006
  • Subclinical Sjogren 症候群を合併した1型糖尿病の2例
    SASAKI S.; INOGUCHI T.; OHTSUKA R.; SONTA T.; TSUBOUCHI H.; SATO N.; ETOH T.; SONODA N.; SEKIGUCHI N.; KOBAYASHI K.; NAWATA H.
    Journal of the Japan Diabetes Society, 28 Feb. 2005
  • Overexpression of ADRP in transgenic mice leads to lipid accumulation and metabolic disorders
    N Sonoda; T Inoguchi; M Imamura; H Morinaga; K Kobayashi; T Etoh; N Sato; N Sekiguchi; M Nomura; S Taniguchi; S Ikuyama; H Nawata
    DIABETES, Jun. 2004
  • 特異なインスリン過剰分泌反応を呈し,ボグリボースで改善を認め,アセタゾラミド併用で症状が消失した特発性低カリウム性周期性四肢麻痺の1例
    坪内 博孝; 井口 登與志; 孫田 淑代; 許斐 朝子; 今村 美菜子; 江藤 隆; 垣本 真如子; 佐藤 直市; 小林 邦久; 中島 直樹; 野村 政壽; 名和田 新
    Journal of the Japan Diabetes Society, 30 Jan. 2003
■ Books and other publications
  • 日本再生のための医療連携
    中島 直樹; 井口 登與志; 髙栁涼一, Joint work, 147-152
    ライフメディコム, Nov. 2012
  • 糖尿病細小血管症
    Joint work, 45-48
    日本臨床, Nov. 2010
  • コメディカル・研修医・一般臨床医のための糖尿病治療ハンドブック-基本的な考え方とその実践・心理的アプローチ-
    Joint work
    医学出版, Apr. 2009
  • 見直されたビグアナイド 塩酸メトホルミン 改訂版
    Joint work
    フジメディカル出版, 2009
  • 地域医療連携パスの作成術・活用術 診療ネットワークづくりをめざして
    Single work
    医学書院, 2007
  • 見直されたビグアナイド 塩酸メトホルミン
    Joint work
    フジメディカル出版, 2005
  • Very low density lipoprotein receptor gene therapy in a mouse model of familial hypercholesterolemia.<BR>(1996)
    Joint work, 249-253
    Drugs Affecting Lipid Metabolism, 1996
  • Very low density lipoprotein receptor gene therapy in a mouse model of familial hypercholesterolemia.
    (1996)
    Joint work, 249-253
    Drugs Affecting Lipid Metabolism, 1996
■ Lectures, oral presentations, etc.
  • 糖尿病における脂質代謝異常
    小林邦久
    第59回日本糖尿病学会九州地方会, 19 Nov. 2021
  • 医療者・保険者の協働をサポートする遠隔疾病管理
    第12回日本プライマリ・ケア連合学会学術大会, 21 May 2021, 日本プライマリ・ケア連合学会
  • 保険者が推進する遠隔医療
    小林邦久; 西田大介; 日山富士代; 中島直樹; 井口登與志
    日本糖尿病学会第58回九州地方会, 12 Oct. 2020, 日本糖尿病学会九州支部
  • 下垂体偶発腫の臨床的特徴における検討 二施設共同研究
    石井 康大; 阿部 一朗; 亀田 亘; 森永 裕介; 伊藤 美以子; 羽田 幸里香; 高瀬 薫; 杉本 薫; 藤井 秀幸; 大石 華子; 越智 健太郎; 山尾 有加; 峯崎 みどり; 高士 祐一; 工藤 忠睦; 阿部 真紀子; 東 登志夫; 園田 順彦; 石澤 賢一; 小林 邦久
    日本内分泌学会雑誌, Aug. 2020, (一社)日本内分泌学会
  • 中性脂肪について知っておきたいこと-糖尿病患者のよりよい脂質管理のために-
    小林邦久
    第11回 日本プライマリ・ケア連合学会学術大会, 23 Jul. 2020
  • 「みえる・つながる」を意識した療養指導
    小林邦久; 西田大介; 日山富士代; 中島直樹; 井口登與志
    第57回日本糖尿病学会九州地方会, 26 Oct. 2019
  • 高中性脂肪血症の成因
    小林 邦久
    中性脂肪学会第2回学術集会, 17 Nov. 2018, 中性脂肪学会
  • 糖尿病と中性脂肪代謝異常
    小林邦久
    第52回 糖尿病学の進歩, 03 Mar. 2018, 日本糖尿病学会
  • 高インスリン血症とスルフォニルウレア剤の使用は独立して左心室拡張機能障害と関連する
    井上 智彰; 前田 泰孝; 園田 紀之; 小林 邦久; 佐々木 修二; 小川 佳宏; 井口 登與志
    糖尿病, Apr. 2017, (一社)日本糖尿病学会
  • 糖尿病状態における脂質代謝異常に対する新しいアプローチ
    小林邦久
    第53回 日本糖尿病学会九州地方会, 27 Nov. 2015, 日本糖尿病学会
  • パンデミックとしての肥満と糖尿病
    小林邦久
    西日本肥満研究会, 12 Jul. 2015
  • 細胞内脂質代謝と臓器機能
    小林邦久
    Forum on Growth Hormone Research 2014, 10 May 2014
  • 糖尿病治療の最近のトピックス
    小林邦久
    第304回日本内科学会九州地方会 第49回九州支部主催生涯教育講演会, 19 Jan. 2014
  • The Diabetes Pandemic ~an Introduction~
    Kunihisa Kobayashi
    35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society in conjunction with 52nd Annual Conference of Japanese Society for Medical and Biological Engineering, 03 Jul. 2013
  • 糖尿病-最近の知見と求められる医療連携のかたち
    小林邦久
    第27回日本糖尿病合併症学会, 02 Nov. 2012
  • 新時代の糖尿病治療におけるディジーズマネジメントの重要性 〜最新・最善の医療を患者さんに届けるために〜
    第62回日本病院学会, 21 Jun. 2012
  • 糖尿病は検査の病気 〜合併症の発症・進展を予防するために〜
    Kunihisa Kobayashi
    第23回日本臨床化学会 九州支部総会・第57回日本臨床検査医学会 九州地方会 合同総会, 11 Feb. 2012
  • RNA interference-directed Knockdown of Adipose Triglyceride Lipase Enhanced TNFalpha-induced ICAM-1 Expression in Human Aortic Endothelial Cells via PKC-dependent activation of NFk B
    Kunihisa Kobayashi; Tomoaki Inoue
    The First International Symposium on TGCV and NLSD, 26 Nov. 2011
  • シンポジウム2「2型糖尿病治療におけるインクレチン関連薬の位置付け」 DPP-4阻害薬
    小林 邦久
    第49回日本糖尿病学会九州地方会, Oct. 2011
  • 糖尿病性腎症患者アルブミン尿に対するピタバスタチンおよびプラバスタチンの治療効果の比較検討 無作為化非盲検群間比較試験
    木村 佐和; 井口 登與志; 松本 雅裕; 渡辺 淳; 田仲 秀明; 山内 照章; 小林 邦久; 正門 光法; 関口 直孝; 横山 寛明; 藤井 雅一; 佐々木 修二; 前田 泰孝; 武井 涼子; 井手 誠; 前田 麻木; 横溝 久; 井上 智彰; 工藤 佳奈; 高柳 涼一
    糖尿病, Apr. 2011, (一社)日本糖尿病学会
  • 地域医療連携クリティカルパスをもちいた糖尿病ディジーズマネジメント
    小林 邦久
    第21回日本在宅医療学会学術集会, Jun. 2010
  • Endocrinological Features of Triglyceride Deposit Cardiomyovasculopathy
    Kunihisa Kobayashi; Tomoaki Inoue; Toyoshi Inoguchi; Ryoichi Takayanagi
    XX World Congress of International Society for Heart Research, May 2010
  • 膵β細胞機能評価としてのプロインスリン/CPR比の検討(第2報)
    鴨井 佐和; 井口 登與志; 月本 賢美; 的場 ゆか; 藤井 雅一; 前田 泰孝; 平田 英一; 横溝 久; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2010, (一社)日本糖尿病学会
  • ビリベルジンによる糖尿病発症抑制の分子機序に関する検討
    池田 紀子; 井口 登與志; 藤井 雅一; 前田 泰孝; 武井 涼子; 平田 英一; 横溝 久; 鄭 静; 佐藤 美紀子; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2010, (一社)日本糖尿病学会
  • 胎生期・母乳期の高脂肪食摂取による耐糖能変化に関する検討
    横溝 久; 井口 登與志; 藤井 雅一; 前田 泰孝; 平田 英一; 佐藤 美紀子; 武井 涼子; 池田 紀子; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2010, (一社)日本糖尿病学会
  • ビリルビン・ビリベルジンの糸球体・メサンギウム細胞へのNOX4発現抑制効果の検討
    藤井 雅一; 井口 登與志; 前田 泰孝; 平田 英一; 池田 紀子; 武井 涼子; 横溝 久; 佐藤 美紀子; 鄭 静; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2010, (一社)日本糖尿病学会
  • 藻類スピルリナより精製したフィコビリンの糖尿病性腎症改善効果の検討
    鄭 静; 井口 登與志; 藤井 雅一; 前田 泰孝; 池田 紀子; 武井 涼子; 平田 英一; 横溝 久; Hari Hendarto; 井手 誠; 井上 智彰; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2010, (一社)日本糖尿病学会
  • 当科における全身性中性脂肪蓄積症のATGL変異が核局在を惹起する機序の検討
    小林 邦久; 井口 登與志; 井上 智彰; 前田 泰孝; 佐藤 美紀子; 井手 誠; 横溝 久; 平田 英一; 鄭 静; Hendarto Hari; 池田 紀子; 武井 涼子; 藤井 雅一; 中島 直樹; 高柳 涼一
    糖尿病, Apr. 2010, (一社)日本糖尿病学会
  • 胎生期・母乳期の高脂肪食摂取による耐糖能変化に関する検討
    横溝 久; 井口 登與志; 藤井 雅一; 前田 泰孝; 平田 英一; 鄭 静; 武井 涼子; 池田 紀子; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2010, (一社)日本糖尿病学会
  • 膵β細胞機能評価としてのプロインスリン/CPR比の検討
    鴨井 佐和; 的場 ゆか; 藤井 雅一; 前田 泰孝; 平田 英一; 横溝 久; 月本 賢美; 小林 邦久; 井口 登與志; 高柳 涼一
    糖尿病, Apr. 2010, (一社)日本糖尿病学会
  • 藻類スピルリナより精製したフィコシアニンの糖尿病性腎症改善効果の検討(第二報)
    鄭 静; 井口 登與志; 藤井 雅一; 前田 泰孝; 池田 紀子; 武井 涼子; 平田 英一; 横溝 久; 佐藤 美紀子; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2010, (一社)日本糖尿病学会
  • ビリベルジンによる糖尿病発症抑制の分子機序に関する研究
    池田 紀子; 井口 登與志; 藤井 雅一; 前田 泰孝; 鄭 静; 武井 涼子; 平田 英一; 横溝 久; 佐藤 美紀子; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2010, (一社)日本糖尿病学会
  • 事例に学ぶ医療連携-急性期から在宅まで- 糖尿病ディジーズマネジメントのための地域医療連携クリティカルパス
    小林 邦久
    第59回日本病院学会, Jul. 2009
  • db/dbマウスにおけるビリベルジン投与による糖尿病発症抑制に関する研究
    池田 紀子; 井口 登與志; 藤井 雅一; 前田 泰孝; 武井 涼子; 平田 栄一; 横溝 久; 井手 千晴; 佐藤 美紀子; 鄭 静; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2009, (一社)日本糖尿病学会
  • 藻類スピルリナより精製したフィコシアニンの糖尿病腎症改善効果の検討
    鄭 静; 井口 登與志; 江頭 絵里奈; 藤井 雅一; 前田 康孝; 池田 紀子; 武井 涼子; 佐藤 美紀子; 的場 ゆか; 平田 英一; 横溝 久; 井手 千晴; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2009, (一社)日本糖尿病学会
  • ビリルビンおよびビリベルジンはEts-1発現を抑制し、NAD(P)Hオキシダーゼ発現を制御することで、糖尿病性腎症改善効果を示す
    藤井 雅一; 井口 登與志; 前田 泰孝; 平田 英一; 舩越 紀子; 武井 涼子; 鴨井 佐和; 横溝 久; 佐藤 美紀子; 鄭 静; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2009, (一社)日本糖尿病学会
  • 二相性インスリンアナログ製剤を用いた段階的インスリン療法に関する検討
    横溝 久; 井口 登與志; 藤井 雅一; 小林 邦久; 岡田 洋右; 川崎 英二; 水田 雅也; 中崎 満浩; 小宮 一郎; 岩瀬 正典; 名和田 新; 高柳 涼一
    糖尿病, Apr. 2009, (一社)日本糖尿病学会
  • 膵β細胞機能評価としてのプロインスリン/CPR比の検討
    鴨井 佐和; 井口 登與志; 的場 ゆか; 藤井 雅一; 前田 泰孝; 平田 英一; 鄭 静; 武井 涼子; 池田 紀子; 横溝 久; 井手 千晴; 小林 邦久; 高柳 涼一
    糖尿病, Apr. 2009, (一社)日本糖尿病学会
  • 全身性中性脂肪蓄積症におけるAdipose triglyceride lipase(ATGL)の構造および細胞内局在の変化と機能との関係
    小林 邦久; 井口 登與志; 前田 泰孝; 佐藤 美紀子; 横溝 久; 平田 英一; 井手 千晴; 鄭 静; Hendarto Hari; 鴨井 佐和; 池田 紀子; 武井 涼子; 藤井 雅一; 的場 ゆか; 中島 直樹; 高柳 涼一
    糖尿病, Apr. 2009, (一社)日本糖尿病学会
  • シンポジウム2 エネルギー代謝,食シグナルと動脈硬化 The Lack of the C-terminal Domain of Adipose Triglyceride Lipase Causes Neutral Lipid Storage Disease Through Impaired Interactions with Lipid Droplets
    KUNIHISA KOBAYASHI; TOYOSHI INOGUCHI; YASUTAKA MAEDA; MASAKAZU FUJII; RYOICHI TAKAYANAGI
    第40回日本動脈硬化学会総会・学術集会, Jul. 2008
  • Chymase inhibitor prevented diabetic nephropathy via attenuation of oxidative stress and NAD(P)H oxidase expression in diabetic hamsters
    Yasutaka Maeda; Toyoshi Inoguchi; Shuji Sasaki; Masakazu Fujii; Kunihisa Kobayashi; Hidenori Urata; Akira Nishiyama; Ryoichi Takayanagi
    DIABETES, Jun. 2008, AMER DIABETES ASSOC
  • Hyperbilirubinemia and biliverdin administration ameliorates diabetic nephropathy via inhibition of oxidative stress in rodent models of diabetes
    Toyoshi Inoguchi; Toyoshi Inoguchi; Syuji Sasaki; Yasutaka Maeda; Kunihisa Kobayashi; Ryoichi Taka-Yanagi
    DIABETES, Jun. 2008, AMER DIABETES ASSOC
  • The lack of the C-terminal domain of adipose triglyceride lipase causes neutral lipid storage disease though impaired interactions with lipid droplets
    Kunihisa Kobayashi; Toyoshi Inoguchi; Yasutaka Maeda; Masakazu Fuji; Ryoichi Takayanagi
    DIABETES, Jun. 2008, AMER DIABETES ASSOC
  • The Lack of the C-terminal Domain of Adipose Triglyceride Lipase Causes Neutral Lipid Storage Disease Through Impaired Interactions with Lipid Droplets.
    KUNIHISA KOBAYASHI; TOYOSHI INOGUCHI; YASUTAKA MAEDA; MASAKAZU FUJII; RYOICHI TAKAYANAGI
    68th Scientific Sessions of American Diabetes Association, Jun. 2008
  • A case report of congenital generalized lipodystrophy type2 with severe insulin resistance.
    Kunihisa Kobayashi; Noriyuki Sonoda; Toyoshi Inoguchi; Ryoichi Takayanagi
    The 8th Insulin Action Symposium, Sep. 2006
  • Adiponectin inhibits the binding of low-density lipoprotein to biglycan, a vascular proteoglycan.
    Kunihisa Kobayashi; Toyoshi Inoguchi; Noriyuki Sonoda; Naotaka Sekiguchi; Hajime Nawata
    64th Scientific Sessions of American Diabetes Association, Jun. 2004
  • フォーサイトレクチャー9 リポ蛋白リパーゼによるカイロミクロン・VLDL加水分解におけるアポ蛋白Eの役割-アデノウイルスを用いた検討-
    小林邦久; 梅田文夫; 名和田新; Lawrence Chan
    平成11年度日本動脈硬化学会冬季大会, Nov. 1999
  • Molecular Pathogenesis of Diabetic Dyslipidemia in C57BL/ KsJ-db/db Mice.
    K. Kobayashi; T. Forte; L. Chan
    The Second EASD/JDF Oxford Conference "Cardiovascular Disease and Diabetes", Nov. 1996
  • Metabolism of oxidized glycated low density lipoprotein by cultured bovine endothelial cells.
    Kunihisa Kobayashi; Mitsunori Masakado; Jun Watanabe; Susumu Taniguchi; Yasuhiro Ono; Kenichi Iwashige; Toshihiko Yanase; Toshihiko Hashimoto; Yasuhiro Sako; Fumio Umeda; Hajime Nawata
    Symposium on vascular complications of diabetes mellitus, 06 Oct. 1993
■ Affiliated academic society
  • 日本糖尿病協会
  • 日本糖尿病療養指導士認定機構
  • Society for Triglyceride Biology and Medicine
  • 日本病態栄養学会
  • アジア糖尿病学会
  • The Japan Endocrine Society
  • 日本クリニカルパス学会
  • 米国糖尿病学会
  • 日本老年医学会
  • The Japanese Society of Ophthalmic Diabetology
  • 糖尿病合併症学会
  • 日本動脈硬化学会
  • 日本糖尿病学会
  • 日本内科学会
■ Research Themes
  • 中性脂肪蓄積心筋血管症の医療水準と患者QOLの向上に資する研究
    厚生労働省, 厚生労働科学研究費, 開発研究
    Apr. 2022 - Mar. 2024
  • 中性脂肪蓄積心筋血管症の診療に直結するエビデンス創出研究
    国立研究開発法人日本医療研究開発機構, 日本医療研究開発機構研究費
    2020 - 2022
  • 中性脂肪蓄積心筋血管症の診療体制の構築
    厚生労働省, 難治性疾患政策研究事業
    2020 - 2021
  • 中性脂肪蓄積心筋血管症に対する中鎖脂肪酸を含有する医薬品の開発
    AMED, research grants-in-aid for rare and intractable diseases
    01 Apr. 2015 - 31 Mar. 2018
  • 中性脂肪蓄積心筋血管症に対する中鎖脂肪酸を含有する医薬品の開発
    AMED, research grants-in-aid for rare and intractable diseases
    01 Apr. 2014 - 31 Mar. 2018
  • 2025年問題(超高齢社会)に活用する個別性に対応した地域連携クリティカルパスの開発
    The Small and Medium Enterprise Agency, Strategic Foundational Technology Improvement Support Operation
    2015 - 2018
  • 先端融合医療レドックスナビ研究拠点
    文部科学省, イノベーションシステム整備事業
    2011 - 2016
  • 中性脂肪蓄積心筋血管症に対する中鎖脂肪酸を含有する医薬品の開発
    厚生労働省, 厚生労働科学研究費補助金, research grants-in-aid for rare and intractable diseases
    01 Apr. 2012 - 31 Mar. 2015
  • データヘルス計画と連携した糖尿病リモート医療
    厚生労働省, 厚生労働科学研究費補助金
    2014 - 2014
  • 中性脂肪蓄積心筋血管症の病因・病態解明と診断法開発
    厚生労働省, 厚生労働科学研究費補助金・難治性疾患克服研究事業
    01 Apr. 2012 - 31 Mar. 2013
  • 中性脂肪蓄積心筋血管症の発見-その疾患概念の確立、診断法、治療法の開発
    厚生労働省, 厚生労働科学研究費補助金・難治性疾患克服研究事業
    01 Apr. 2010 - 31 Mar. 2012
  • 慢性疾患のガイドライン診療普及法の開発・実証研究
    厚生労働省, 厚生労働科学研究費補助金
    2008 - 2009
■ Social Contribution Activities
  • 福岡県糖尿病対策推進会議
    others
    2018
■ Media Coverage
  • 筑紫保健所運営協議会救急医療部会
    01 Apr. 2018