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Last Updated :2024/03/03

Shuhei Ishikura

School of Medicine
Associate professor

Researcher information

■ Degree
  • 博士(薬学)
■ Research Keyword
  • 細胞周期
  • アポトーシス
  • ZFAT (Zinc-finger protein with AT-hook)
  • 転写制御因子
  • セントロメア
  • ノンコーディングRNA
■ Field Of Study
  • Life sciences, Cell biology
  • Life sciences, Molecular biology
  • Life sciences, Medical biochemistry

Career

■ Career
  • Apr. 2021 - Present
    福岡大学医学部 細胞生物学, 准教授
  • Apr. 2013 - Mar. 2021
    福岡大学医学部 細胞生物学, 講師
  • Jul. 2011 - Mar. 2013
    徳島大学 疾患酵素学研究センター シグナル伝達と糖尿病研究部門, 助教
  • Feb. 2009 - Jun. 2011
    NIH, NICHD, Cell Biology and Metabolism Program, Postdoctoral Fellow
  • Jun. 2005 - Jan. 2009
    The Hospital for Sick Children, Program in Cell Biology, Postdoctoral Fellow
  • Oct. 1998 - May 2005
    岐阜薬科大学 生化学教室, 助手
■ Educational Background
  • 岐阜薬科大学大学院
  • 日本大学薬学部

Research activity information

■ Paper
  • Inhibitory Effect of Pyra–Metho–Carnil on Cancer Spheroid Growth Through Decrease in Glycolysis-associated Molecules
    KAZUMASA YOSHIDA; KENSUKE NISHI; SHUHEI ISHIKURA; TAICHI MATSUMOTO; KAZUHIKO NAKABAYASHI; RYO YAZAKI; TAKASHI OHSHIMA; MASAHIKO SUENAGA; SENJI SHIRASAWA; TOSHIYUKI TSUNODA
    Anticancer Research, 26 Jul. 2023
  • Death domain-associated protein DAXX regulates non-coding RNA transcription at the centromere through the transcription regulator ZFAT.
    Shuhei Ishikura; Kazumasa Yoshida; Toshiyuki Tsunoda; Senji Shirasawa
    The Journal of biological chemistry, 23 Sep. 2022, Refereed, Lead
  • Cancer Spheroid Proliferation Is Suppressed by a Novel Low-toxicity Compound, Pyra-Metho-Carnil, in a Context-independent Manner.
    Kazumasa Yoshida; Kensuke Nishi; Shuhei Ishikura; Kazuhiko Nakabayashi; Ryo Yazaki; Takashi Ohshima; Masahiko Suenaga; Senji Shirasawa; Toshiyuki Tsunoda
    Anticancer research, Aug. 2022, Refereed
  • CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA.
    Shuhei Ishikura; Kazumasa Yoshida; Sayuri Hashimoto; Kazuhiko Nakabayashi; Toshiyuki Tsunoda; Senji Shirasawa
    The Journal of biological chemistry, Oct. 2021, Refereed, Not invited, Lead
  • Growth Suppression of Cancer Spheroids With Mutated KRAS by Low-toxicity Compounds from Natural Products.
    Sayuri Hashimoto; Masayoshi Nagai; Kensuke Nishi; Shuhei Ishikura; Kazuhiko Nakabayashi; Ryo Yazaki; Takashi Ohshima; Masahiko Suenaga; Senji Shirasawa; Toshiyuki Tsunoda
    Anticancer research, Aug. 2021, Refereed, Not invited
  • The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes.
    Shuhei Ishikura; Masayoshi Nagai; Toshiyuki Tsunoda; Kensuke Nishi; Yoko Tanaka; Midori Koyanagi; Senji Shirasawa
    Journal of cellular biochemistry, Jun. 2021, Refereed, Not invited, Lead
  • ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B-H4K8ac-BRD4 axis.
    Shuhei Ishikura; Kazuhiko Nakabayashi; Masayoshi Nagai; Toshiyuki Tsunoda; Senji Shirasawa
    Nucleic acids research, 04 Nov. 2020, Refereed, Not invited, Lead
  • Mutant KRAS Promotes NKG2D+ T Cell Infiltration and CD155 Dependent Immune Evasion.
    Kensuke Nishi; Shuhei Ishikura; Masayo Umebayashi; Takashi Morisaki; Takashi Inozume; Tetsushi Kinugasa; Mikiko Aoki; Satoshi Nimura; Anthony Swain; Yoichiro Yoshida; Suguru Hasegawa; Kazuki Nabeshima; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
    Anticancer research, Aug. 2020, Refereed, Not invited
  • Zfat Is Indispensable for the Development of Erythroid Cells in the Fetal Liver.
    Keiko Doi; Toshiyuki Tsunoda; Midori Koyanagi; Yoko Tanaka; Shiori Yamano; Aya Fujikane; Kensuke Nishi; Shuhei Ishikura; Senji Shirasawa
    Anticancer research, Aug. 2019, Refereed, Not invited
  • Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis.
    Toshiyuki Tsunoda; Keiko Doi; Shuhei Ishikura; Hao Luo; Kensuke Nishi; Hiroshi Matsuzaki; Midori Koyanagi; Yoko Tanaka; Tadashi Okamura; Senji Shirasawa
    International journal of molecular medicine, Nov. 2018, Refereed, Not invited, Lead
  • Growth Suppression of Human Colorectal Cancer Cells with Mutated KRAS by 3-Deaza-cytarabine in 3D Floating Culture.
    Hao Luo; Kensuke Nishi; Shuhei Ishikura; Anthony Swain; Naoyuki Morishige; Ryo Yazaki; Takashi Ohshima; Senji Shirasawa; Toshiyuki Tsunoda
    Anticancer research, Jul. 2018, Refereed, Not invited
  • ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line.
    Kensuke Nishi; Yuri Iwaihara; Toshiyuki Tsunoda; Keiko Doi; Toshifumi Sakata; Senji Shirasawa; Shuhei Ishikura
    Cell death & disease, 14 Dec. 2017, Refereed, Not invited, Last
  • Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS.
    Kensuke Nishi; Hao Luo; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Lauren Wills; George S Baillie; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
    Anticancer research, Jul. 2017, Refereed, Not invited
  • An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.
    Kensuke Nishi; Hao Luo; Kazuhiko Nakabayashi; Keiko Doi; Shuhei Ishikura; Yuri Iwaihara; Yasuhiro Yoshida; Kumpei Tanisawa; Tomio Arai; Seijiro Mori; Motoji Sawabe; Masaaki Muramatsu; Masashi Tanaka; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
    Anticancer research, Jul. 2017, Refereed, Not invited
  • Sequential cleavage of insulin receptor by calpain 2 and γ-secretase impairs insulin signalling.
    Tomoyuki Yuasa; Kikuko Amo-Shiinoki; Shuhei Ishikura; Mitsuyoshi Takahara; Takaaki Matsuoka; Hideaki Kaneto; Akio Kuroda; Munehide Matsuhisa; Seiichi Hashida
    Diabetologia, Dec. 2016, Refereed
  • Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells.
    Shuhei Ishikura; Toshiyuki Tsunoda; Kazuhiko Nakabayashi; Keiko Doi; Midori Koyanagi; Keiko Hayashi; Tomoko Kawai; Yoko Tanaka; Yuri Iwaihara; Hao Luo; Kensuke Nishi; Tadashi Okamura; Senji Shirasawa
    Biochimica et biophysica acta, Nov. 2016, Refereed, Not invited, Lead
  • The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway.
    Shuhei Ishikura; Yuri Iwaihara; Yoko Tanaka; Hao Luo; Kensuke Nishi; Keiko Doi; Midori Koyanagi; Tadashi Okamura; Toshiyuki Tsunoda; Senji Shirasawa
    The Journal of biological chemistry, 15 Jul. 2016, Refereed, Not invited, Lead
  • Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells.
    Yuri Iwaihara; Shuhei Ishikura; Keiko Doi; Toshiyuki Tsunoda; Takahiro Fujimoto; Tadashi Okamura; Senji Shirasawa
    Anticancer research, Aug. 2015, Refereed, Not invited
  • Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules.
    Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Hiromasa Hidesima; Hao Luo; Yumiko Hirose; Senji Shirasawa
    Anticancer research, Aug. 2015, Refereed, Not invited
  • Zfat-deficient CD4⁺ CD8⁺ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.
    Shuhei Ishikura; Masahiro Ogawa; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Yoko Tanaka; Toshiyuki Tsunoda; Hiromasa Hideshima; Tadashi Okamura; Senji Shirasawa
    Journal of cellular biochemistry, Jan. 2015, Refereed, Not invited, Lead
  • The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.
    Keiko Doi; Shuhei Ishikura; Senji Shirasawa
    Anticancer research, Aug. 2014, Refereed, Not invited
  • Resveratrol induces luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture.
    Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Senji Shirasawa
    Anticancer research, Aug. 2014, Refereed, Not invited
  • Ca²⁺ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells.
    Q Li; X Zhu; S Ishikura; D Zhang; J Gao; Y Sun; A Contreras-Ferrat; K P Foley; S Lavandero; Z Yao; P J Bilan; A Klip; W Niu
    American journal of physiology. Endocrinology and metabolism, 15 Jul. 2014, Refereed
  • Development of in vitro model of insulin receptor cleavage induced by high glucose in HepG2 cells.
    Tomoyuki Yuasa; Kikuko Amo; Shuhei Ishikura; Hisao Nagaya; Keiji Uchiyama; Seiichi Hashida; Yousuke Ebina
    Biochemical and biophysical research communications, 28 Feb. 2014, Refereed
  • Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.
    Masahiro Ogawa; Tadashi Okamura; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yoko Tanaka; Takeharu Ota; Kunihiro Hayakawa; Harumi Suzuki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
    PloS one, 03 Oct. 2013, Refereed, Not invited
  • Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein.
    Shuhei Ishikura; Allan M Weissman; Juan S Bonifacino
    The Journal of biological chemistry, 30 Jul. 2010, Refereed, Lead
  • Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells.
    Wenyan Niu; Philip J Bilan; Shuhei Ishikura; Jonathan D Schertzer; Ariel Contreras-Ferrat; Zhengxiang Fu; Jie Liu; Shlomit Boguslavsky; Kevin P Foley; Zhi Liu; Jinru Li; Guilan Chu; Thomas Panakkezhum; Gary D Lopaschuk; Sergio Lavandero; Zhi Yao; Amira Klip
    American journal of physiology. Endocrinology and metabolism, May 2010, Refereed
  • Documenting GLUT4 exocytosis and endocytosis in muscle cell monolayers.
    Shuhei Ishikura; Costin N Antonescu; Amira Klip
    Current protocols in cell biology, Mar. 2010, Refereed, Lead
  • The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2.
    Sean M Hartig; Shuhei Ishikura; Rachel S Hicklen; Yanming Feng; Elisabeth G Blanchard; Kevin A Voelker; Christina S Pichot; Robert W Grange; Robert M Raphael; Amira Klip; Seth J Corey
    Journal of cell science, 01 Jul. 2009, Refereed
  • Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase.
    H-T Zhao; S Endo; S Ishikura; R Chung; P J Hogg; A Hara; O El-Kabbani
    Cellular and molecular life sciences : CMLS, May 2009, Refereed
  • GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.
    Varinder K Randhawa; Shuhei Ishikura; Ilana Talior-Volodarsky; Alex W P Cheng; Nish Patel; John H Hartwig; Amira Klip
    The Journal of biological chemistry, 03 Oct. 2008, Refereed
  • Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.
    Shuhei Ishikura; Amira Klip
    American journal of physiology. Cell physiology, Oct. 2008, Refereed, Lead
  • Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity.
    Toshiyuki Matsunaga; Satoshi Endo; Satoshi Maeda; Shuhei Ishikura; Kazuo Tajima; Nobutada Tanaka; Kazuo T Nakamura; Yorishige Imamura; Akira Hara
    Archives of biochemistry and biophysics, 15 Sep. 2008, Refereed
  • Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid.
    Vincenzo Carbone; Rie Sumii; Shuhei Ishikura; Yukuhiko Asada; Akira Hara; Ossama El-Kabbani
    Acta crystallographica. Section D, Biological crystallography, May 2008, Refereed
  • Molecular basis for peroxisomal localization of tetrameric carbonyl reductase.
    Nobutada Tanaka; Ken-Ichi Aoki; Shuhei Ishikura; Makoto Nagano; Yorishige Imamura; Akira Hara; Kazuo T Nakamura
    Structure (London, England : 1993), Mar. 2008, Refereed
  • Small G proteins in insulin action: Rab and Rho families at the crossroads of signal transduction and GLUT4 vesicle traffic.
    S Ishikura; A Koshkina; A Klip
    Acta physiologica (Oxford, England), Jan. 2008, Refereed, Lead
  • Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.
    Satoshi Endo; Masaharu Sanai; Kenji Horie; Toshiyuki Matsunaga; Shuhei Ishikura; Kazuo Tajima; Ossama El-Kabbani; Akira Hara
    Archives of biochemistry and biophysics, 01 Nov. 2007, Refereed
  • Characterization of an oligomeric carbonyl reductase of dog liver: its identity with peroxisomal tetrameric carbonyl reductase.
    Satoshi Endo; Toshiyuki Matsunaga; Makoto Nagano; Hiroko Abe; Syuhei Ishikura; Yorishige Imamura; Akira Hara
    Biological & pharmaceutical bulletin, Sep. 2007, Refereed
  • Rat NAD+-dependent 3alpha-hydroxysteroid dehydrogenase (AKR1C17): a member of the aldo-keto reductase family highly expressed in kidney cytosol.
    Masaharu Sanai; Satoshi Endo; Toshiyuki Matsunaga; Shuhei Ishikura; Kazuo Tajima; Ossama El-Kabbani; Akira Hara
    Archives of biochemistry and biophysics, 01 Aug. 2007, Refereed
  • Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells.
    Shuhei Ishikura; Philip J Bilan; Amira Klip
    Biochemical and biophysical research communications, 23 Feb. 2007, Refereed, Lead
  • Stereoselective reduction of 4-benzoylpyridine in the heart of vertebrates.
    Hideaki Shimada; Koji Imaishi; Takaomi Hirashima; Takeshi Kitano; Shuhei Ishikura; Akira Hara; Yorishige Imamura
    Life sciences, 16 Jan. 2007, Refereed
  • Substrate specificity of a mouse aldo-keto reductase (AKR1C12).
    Satoshi Endo; Kengo Matsumoto; Toshiyuki Matsunaga; Shuhei Ishikura; Kazuo Tajima; Ossama El-Kabbani; Akira Hara
    Biological & pharmaceutical bulletin, Dec. 2006, Refereed
  • Crystallization and preliminary X-ray crystallographic studies of pig heart carbonyl reductase.
    Ken-ichi Aoki; Nobutada Tanaka; Shuhei Ishikura; Naoko Araki; Yorishige Imamura; Akira Hara; Kazuo T Nakamura
    Acta crystallographica. Section F, Structural biology and crystallization communications, 01 Oct. 2006, Refereed
  • Molecular cloning of a novel type of rat cytoplasmic 17beta-hydroxysteroid dehydrogenase distinct from the type 5 isozyme.
    Shuhei Ishikura; Kengo Matsumoto; Masaharu Sanai; Kenji Horie; Toshiyuki Matsunaga; Kazuo Tajima; Ossama El-Kabbani; Akira Hara
    Journal of biochemistry, Jun. 2006, Refereed, Lead
  • Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.
    Kengo Matsumoto; Satoshi Endo; Shuhei Ishikura; Toshiyuki Matsunaga; Kazuo Tajima; Ossama El-Kabbani; Akira Hara
    Biological & pharmaceutical bulletin, Mar. 2006, Refereed
  • Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.
    Ossama El-Kabbani; Vincenzo Carbone; Connie Darmanin; Syuhei Ishikura; Akira Hara
    Proteins, 15 Aug. 2005, Refereed
  • Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.
    Ossama El-Kabbani; Syuhei Ishikura; Armin Wagner; Clemens Schulze-Briese; Akira Hara
    Acta crystallographica. Section F, Structural biology and crystallization communications, 01 Jul. 2005, Refereed
  • Enzymatic properties of a member (AKR1C19) of the aldo-keto reductase family.
    Shuhei Ishikura; Kenji Horie; Masaharu Sanai; Kengo Matsumoto; Akira Hara
    Biological & pharmaceutical bulletin, Jun. 2005, Refereed, Lead
  • Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase.
    Syuhei Ishikura; Noriyuki Usami; Mayuko Araki; Akira Hara
    Journal of biochemistry, Mar. 2005, Refereed, Lead
  • Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking.
    Vincenzo Carbone; Syuhei Ishikura; Akira Hara; Ossama El-Kabbani
    Bioorganic & medicinal chemistry, 17 Jan. 2005, Refereed
  • Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.
    Syuhei Ishikura; Noriyuki Usami; Satoko Nakajima; Akiko Kameyama; Hiroaki Shiraishi; Vincenzo Carbone; Ossama El-Kabbani; Akira Hara
    Biological & pharmaceutical bulletin, Dec. 2004, Refereed, Lead
  • Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis.
    Ossama El-Kabbani; Shuhei Ishikura; Connie Darmanin; Vincenzo Carbone; Roland P-T Chung; Noriyuki Usami; Akira Hara
    Proteins, 15 May 2004, Refereed
  • Structural determinant for cold inactivation of rodent L-xylulose reductase.
    Shuhei Ishikura; Noriyuki Usami; Ossama El-Kabbani; Akira Hara
    Biochemical and biophysical research communications, 15 Aug. 2003, Refereed, Lead
  • Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
    Teruhiko Iino; Mayuko Tabata; Shin-Ichiro Takikawa; Hiroshi Sawada; Haruo Shintaku; Shuhei Ishikura; Akira Hara
    Archives of biochemistry and biophysics, 15 Aug. 2003, Refereed
  • Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme.
    Vincenzo Carbone; Connie Darmanin; Shuhei Ishikura; Akira Hara; Ossama El-Kabbani
    Bioorganic & medicinal chemistry letters, 17 Apr. 2003, Refereed
  • Cloning, expression and tissue distribution of a tetrameric form of pig carbonyl reductase.
    Noriyuki Usami; Shuhei Ishikura; Hiroko Abe; Makoto Nagano; Miki Uebuchi; Akihiko Kuniyasu; Masaki Otagiri; Hitoshi Nakayama; Yorishige Imamura; Akira Hara
    Chemico-biological interactions, 01 Feb. 2003, Refereed
  • Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone.
    Yu Higaki; Noriyuki Usami; Syunichi Shintani; Shuhei Ishikura; Ossama El-Kabbani; Akira Hara
    Chemico-biological interactions, 01 Feb. 2003, Refereed
  • Identification of amino acid residues involved in substrate recognition of L-xylulose reductase by site-directed mutagenesis.
    Shuhei Ishikura; Tomoya Isaji; Noriyuki Usami; Junichi Nakagawa; Ossama El-Kabbani; Akira Hara
    Chemico-biological interactions, 01 Feb. 2003, Refereed, Lead
  • Crystallization and preliminary crystallographic analysis of human L-xylulose reductase.
    Ossama El-Kabbani; Roland P T Chung; Syuhei Ishikura; Noriyuki Usami; Junichi Nakagawa; Akira Hara
    Acta crystallographica. Section D, Biological crystallography, Aug. 2002, Refereed
  • Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.
    Junichi Nakagawa; Syuhei Ishikura; Jun Asami; Tomoya Isaji; Noriyuki Usami; Akira Hara; Takanobu Sakurai; Katsuki Tsuritani; Koji Oda; Masayoshi Takahashi; Makoto Yoshimoto; Noboru Otsuka; Kunihiro Kitamura
    The Journal of biological chemistry, 17 May 2002, Refereed
  • Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines.
    Noriyuki Usami; Tomohiro Yamamoto; Syunichi Shintani; Shuhei Ishikura; Yu Higaki; Yoshihiro Katagiri; Akira Hara
    Biological & pharmaceutical bulletin, Apr. 2002, Refereed
  • Crystallization and preliminary X-ray diffraction analysis of monkey dimeric dihydrodiol dehydrogenase.
    Ossama El-Kabbani; Roland P T Chung; Paul A Ramsland; Yukuhiko Asada; Syuhei Ishikura; Noriyuki Usami; Akira Hara
    Acta crystallographica. Section D, Biological crystallography, Jan. 2002, Refereed
  • Molecular characterization of two monkey dihydrodiol dehydrogenases.
    Yu Higaki; Takeshi Kamiya; Noriyuki Usami; Syunichi Shintani; Hiroaki Shiraishi; Shuhei Ishikura; Ikuo Yamamoto; Akira Hara
    Drug metabolism and pharmacokinetics, 2002, Refereed
  • Characterization of a major form of human isatin reductase and the reduced metabolite.
    N Usami; K Kitahara; S Ishikura; M Nagano; S Sakai; A Hara
    European journal of biochemistry, Nov. 2001, Refereed
  • Identity of dimeric dihydrodiol dehydrogenase as NADP(+)-dependent D-xylose dehydrogenase in pig liver.
    S Aoki; S Ishikura; Y Asada; N Usami; A Hara
    Chemico-biological interactions, 30 Jan. 2001, Refereed
  • Molecular cloning, expression and tissue distribution of hamster diacetyl reductase. Identity with L-xylulose reductase.
    S Ishikura; T Isaji; N Usami; K Kitahara; J Nakagawa; A Hara
    Chemico-biological interactions, 30 Jan. 2001, Refereed, Lead
  • Enzymatic characteristics and subcellular distribution of a short-chain dehydrogenase/reductase family protein, P26h, in hamster testis and epididymis.
    S Ishikura; N Usami; K Kitahara; T Isaji; K Oda; J Nakagawa; A Hara
    Biochemistry, 09 Jan. 2001, Refereed, Lead
  • Kinetic alteration of a human dihydrodiol/3alpha-hydroxysteroid dehydrogenase isoenzyme, AKR1C4, by replacement of histidine-216 with tyrosine or phenylalanine.
    T Ohta; S Ishikura; S Shintani; N Usami; A Hara
    The Biochemical journal, 15 Dec. 2000, Refereed
  • Roles of His-79 and Tyr-180 of D-xylose/dihydrodiol dehydrogenase in catalytic function.
    Y Asada; S Aoki; S Ishikura; N Usami; A Hara
    Biochemical and biophysical research communications, 19 Nov. 2000, Refereed
  • Structure-specific effects of thyroxine analogs on human liver 3 alpha-hydroxysteroid dehydrogenase.
    T Yamamoto; A Nozaki; S Shintani; S Ishikura; Y Katagiri; A Hara
    Journal of biochemistry, Jul. 2000, Refereed
  • Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases.
    E Arimitsu; S Aoki; S Ishikura; K Nakanishi; K Matsuura; A Hara
    The Biochemical journal, 15 Sep. 1999, Refereed
  • Inhibition of human aldehyde reductase by drugs for testing the function of liver and kidney.
    M Shinoda; S Mori; S Shintani; S Ishikura; A Hara
    Biological & pharmaceutical bulletin, Jul. 1999, Refereed
  • Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimaeric enzymes.
    K Matsuura; A Hara; Y Deyashiki; H Iwasa; T Kume; S Ishikura; H Shiraishi; Y Katagiri
    The Biochemical journal, 01 Dec. 1998, Refereed
  • Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA.
    H Shiraishi; S Ishikura; K Matsuura; Y Deyashiki; M Ninomiya; S Sakai; A Hara
    The Biochemical journal, 01 Sep. 1998, Refereed
  • Properties and tissue distribution of mouse monomeric carbonyl reductase.
    S Ishikura; Y Yamamoto; K Matsuura; J Wei; M E Hodes; A Hara
    Biological & pharmaceutical bulletin, Aug. 1998, Refereed, Lead
  • Activation of human liver 3alpha-hydroxysteroid dehydrogenase by clofibrate derivatives.
    K Matsuura; A Hara; M Kato; Y Deyashiki; Y Miyabe; S Ishikura; T Sugiyama; Y Katagiri
    The Journal of pharmacology and experimental therapeutics, Jun. 1998, Refereed
■ Affiliated academic society
  • 日本生化学会
■ Research Themes
  • セントロメアDNA損傷修復におけるZFATの役割とB細胞リンパ腫との関連の解明
    基盤研究(C)
    福岡大学
    01 Apr. 2023 - 31 Mar. 2026
  • ZfatによるセントロメアノンコーディングRNA転写制御機構とガンとの関連の解明
    基盤研究(C)
    福岡大学
    01 Apr. 2020 - 31 Mar. 2023
  • Binding of soluble insulin receptor to insulin
    Grant-in-Aid for Young Scientists (B)
    01 Apr. 2012 - 31 Mar. 2014
  • Development of drugs targeting neurosteroid-metabolizing enzymes
    Grant-in-Aid for Scientific Research (B)
    Gifu Pharmaceutical University
    1999 - 2001