2023年09月
Traditional and Kampo medicine誌, Top Cited Award 2022 In Traditional and Kampo medicine
Effects of two kinds of Kampo-hozai, ninjinyoeito and kamikihito, on mental disorder-like behaviors in senescence-accelerated mouse- prone 8 mice
Marika Hirata, Chise Taniguchi, Takuya Watanabe, Toru Horikawa, Yufuko Akizuki, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki

2021年09月04日
和漢医薬学会, 和漢医薬学会 学術貢献賞
易怒性・攻撃性に対して抑制効果を示す漢方薬の作用機序探索, 国内学会・会議・シンポジウム等の賞
渡辺拓也

2018年08月
公益社団法人日本薬学会薬理系薬学部会, 生体機能と創薬シンポジウム優秀発表賞
発達障害で認められる社会性行動障害の治療を目的とした漢方薬の探索, 国内学会・会議・シンポジウム等の賞
渡辺拓也

2012年01月
上原記念生命科学財団, 海外留学助成ポストドクトラルフェローシップ
出版社・新聞社・財団等の賞

Location analysis of presynaptically active and silent synapses in single-cultured hippocampal neurons
Otoya Kitaoka; Kohei Oyabu; Kaori Kubota; Takuya Watanabe; Satoru Kondo; Teppei Matsui; Shutaro Katsurabayashi; Katsunori Iwasaki
2023年12月13日

The Effects of Ninjinyoeito on Impaired Spatial Memory and Prefrontal Cortical Synaptic Plasticity through α-Amino-3-hydroxy-5-4-isoxazole Propionic Acid Receptor Subunit in a Rat Model with Cerebral Ischemia and β-Amyloid Injection
Masaki Nagao; Akinobu Hatae; Kazuma Mine; Soichiro Tsutsumi; Hiroya Omori; Marika Hirata; Maaya Arimatsu; Chise Taniguchi; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Evidence-Based Complementary and Alternative Medicine, 2023年09月30日

Ninjinyoeito Prevents Onset of Depression-Like Behavior and Reduces Hippocampal iNOS Expression in Senescence-Accelerated Mouse Prone 8 Mice
Chise Taniguchi; Takuya Watanabe; Marika Hirata; Akinobu Hatae; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Evidence-Based Complementary and Alternative Medicine, 2023年08月09日

Astrocyte Ca2+ signaling is facilitated in Scn1a+/− mouse model of Dravet syndrome
Kouya Uchino; Yasuyoshi Tanaka; Wakana Ikezawa; Masanobu Deshimaru; Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Katsunori Iwasaki; Shinichi Hirose
Biochemical and Biophysical Research Communications, 2023年02月

Kamishoyosan Alleviates Anxiety-like Behavior in a Premenstrual Syndrome Rat Model
Hikari Iba-Tanaka; Takuya Watanabe; Kyoka Harada; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Evidence-Based Complementary and Alternative Medicine, 2022年10月14日

Establishment of autaptic culture with human induced pluripotent stem cell-derived astrocytes
Uchino K; Tanaka Y; Kawaguchi S; Kubota K; Watanabe T; Katsurabayashi S; Hirose S; Iwasaki K
iScience, 2022年08月, 査読有り

Ninjinyoeito reduces β‐amyloid_25–35‐induced axon damage via nerve growth factor
Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Katsunori Iwasaki
Traditional & Kampo Medicine, 2022年06月21日

Sansoninto attenuates aggressive behavior and increases levels of homovanillic acid, a dopamine metabolite, in social isolation-reared mice
Takuya Watanabe; Hikari Iba; Hiroshi Moriyama; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of Traditional and Complementary Medicine, 2022年05月, 査読有り

Ninjinyoeito exerts an antidepressant-like effect by enhancing the central noradrenergic system
Soichiro Tsutsumi; Takuya Watanabe; Akinobu Hatae; Marika Hirata; Hiroya Omori; Chise Taniguchi; Masaki Nagao; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Traditional & Kampo Medicine, 2022年04月03日, 査読有り

Kamishoyosan potentiates pentobarbital-induced sleep in socially isolated, ovariectomized mice
Nobuaki Egashira; Yu Goto; Hikari Iba; Rikako Kawanaka; Ryota Takahashi; Chise Taniguchi; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of Ethnopharmacology, 2021年12月05日, 査読有り

Behavioral profile in a Dctn1G71A knock-in mouse model of Perry disease
Manami Deshimaru; Takayasu Mishima; Takuya Watanabe; Kaori Kubota; Mana Hosoi; Mariko Kinoshita-Kawada; Junichi Yuasa-Kawada; Maiko Ikeda; Masayoshi Mori; Yusuke Murata; Takaya Abe; Munechika Enjoji; Hiroshi Kiyonari; Shohta Kodama; Shinsuke Fujioka; Katsunori Iwasaki; Yoshio Tsuboi
Neuroscience Letters, 2021年11月01日, 査読有り

Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats
Nobuaki Egashira; Yu Goto; Ryota Takahashi; Hikari Iba; Shota Yamamoto; Takuya Watanabe; Kaori Kubota; Takehiro Kawashiri; Chise Taniguchi; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of Pharmacological Sciences, 2021年09月, 査読有り

The novel mitochondria activator, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), promotes the development of hippocampal neuronal morphology
Shutaro Katsurabayashi; Kohei Oyabu; Kaori Kubota; Takuya Watanabe; Tomohisa Nagamatsu; Norio Akaike; Katsunori Iwasaki
Biochemical and Biophysical Research Communications, 2021年06月30日, 査読有り

Effects of two kinds of Kampo-hozai, ninjinyoeito and kamikihito, on mental disorder-like behaviors in senescence-accelerated mouse-prone 8 mice
Marika Hirata; Chise Taniguchi; Takuya Watanabe; Toru Horikawa; Yufuko Akizuki; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Traditional & Kampo Medicine, 2021年06月15日, 査読有り

Inhibitory synaptic transmission is impaired at higher extracellular Ca 2+ concentrations in Scn1a +/- mouse model of Dravet syndrome
Kouya Uchino; Hiroyuki Kawano; Yasuyoshi Tanaka; Yuna Adaniya; Ai Asahara; Masanobu Deshimaru; Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Katsunori Iwasaki; Shinichi Hirose
Scientific reports, 2021年05月20日, 査読有り

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
Manami Deshimaru; Mariko Kinoshita-Kawada; Kaori Kubota; Takuya Watanabe; Yasuyoshi Tanaka; Saito Hirano; Fumiyoshi Ishidate; Masaki Hiramoto; Mitsuru Ishikawa; Yoshinari Uehara; Hideyuki Okano; Shinichi Hirose; Shinsuke Fujioka; Katsunori Iwasaki; Junichi Yuasa-Kawada; Takayasu Mishima; Yoshio Tsubo
International Journal of Molecular Sciences, 2021年04月13日, 査読有り

マウスのガラス玉覆い隠し行動に対するメマンチン塩酸塩OD錠「ニプロ」の抑制効果
長尾昌紀; 射場日佳里; 弟子丸眞実; 内野鉱也; 平田茉莉花; 堤宗一朗; 渡辺拓也; 岩崎克典
医学と薬学, 2021年02月, 査読有り

Valproic acid-exposed astrocytes impair inhibitory synapse formation and function
Kotomi Takeda; Takuya Watanabe; Kohei Oyabu; Shuntaro Tsukamoto; Yuki Oba; Takafumi Nakano; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Scientific reports, 2021年01月08日, 査読有り

A Japanese herbal medicine attenuates anxiety-like behavior through GABA A receptor and brain-derived neurotrophic factor expression in a rat model of premenstrual syndrome
Hikari Iba; Takuya Watanabe; Saori Motomura; Kyoka Harada; Haruka Uesugi; Takenori Shibahara; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of pharmacological sciences, 2021年01月, 査読有り

Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus
Motokazu Uchigashima; Kohtarou Konno; Emily Demchak; Amy Cheung; Takuya Watanabe; David G Keener; Manabu Abe; Timmy Le; Kenji Sakimura; Toshikuni Sasaoka; Takeshi Uemura; Yuka Imamura Kawasawa; Masahiko Watanabe; Kensuke Futai
Elife, 2020年12月23日, 査読有り

Presynaptically silent synapses are modulated by the density of surrounding astrocytes
Kohei Oyabu; Kotomi Takeda; Hiroyuki Kawano; Kaori Kubota; Takuya Watanabe; N Charles Harata; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of pharmacological sciences, 2020年10月, 査読有り

Neuroligin3 splice isoforms shape inhibitory synaptic function in the mouse hippocampus.
Uchigashima, M; Leung, M; Watanabe, T; Cheung, A; Le, T; Pallat, S; Dinis, A; Watanabe, M; Kawasawa, Y. I; Futai, K
The Journal of biological chemistry, 2020年06月19日, 査読有り

Oligodendrocytes upregulate blood-brain barrier function through mechanisms other than the PDGF-BB/PDGFRα pathway in the barrier-tightening effect of oligodendrocyte progenitor cells.
Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Takuro Iwao; Atsushi Yamauchi; Yasufumi Kataoka
Neuroscience Letters, 2019年10月

Effect of yokukansan and yokukansankachimpihange on aggressive behavior, 5-HT receptors and arginine vasopressin expression in social isolation-reared mice
Iba H; Watanabe T; Matsuzawa K; Saimiya M; Tanaka M; Moriyama H; Kubota K; Katsurabayashi S; Iwasaki K
Biological and Pharmaceutical Bulletin, 2019年09月, 査読有り

Hippocampal neurons in direct contact with astrocytes exposed to amyloid β25-35 exhibit reduced excitatory synaptic transmission
Kohei Oyabu; Hiroki Kiyota; Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Katsunori Iwasaki
IBRO Reports, 2019年07月, 査読有り

Effect of Lactobacillus paracasei A221‐fermented ginseng on impaired spatial memory in a rat model with cerebral ischemia and β‐amyloid injection
Masaki Nagao; Satoshi Yamano; Naoki Imagawa; Kentaro Igami; Toshitsugu Miyazaki; Hisatomi Ito; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Traditional & Kampo Medicine, 2019年05月, 査読有り

Extract of Yokukansan improves anxiety-like behavior and increases serum brain-derived neurotrophic factor in rats with cerebral ischemia combined with amyloid-β42 peptide
Ai Nogami-Hara; Kaori Kubota; Kotaro Takasaki; Takuya Watanabe; Nobuaki Egahira; Hikari Iba; Risako Fujikawa; Shutaro Katsurabayashi; Funda Bolukbasi Hatip; Izzettin Hatip-Al-Khatib; Katsunori Iwasaki
Journal of Traditional Chinese Medicine, 2019年02月15日, 査読有り

不眠に処方される漢方薬の作用機序
岩崎克典; 長尾昌紀; 森山博史; 渡辺拓也
Progress in Medicine, 2018年10月

The Japanese Angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia
Ai Nogami-Hara; Masaki Nagao; Kotaro Takasaki; Nobuaki Egashira; Risako Fujikawa; Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Funda Bolukbasi Hatip; Izzettin Hatip-Al-Khatib; Katsunori Iwasaki
Journal of Ethnopharmacology, 2018年03月25日, 査読有り

Behavioral defects in a DCTN1G71A transgenic mouse model of Perry syndrome
Takayasu Mishima; Manami Deshimaru; Takuya Watanabe; Kaori Kubota; Mariko Kinoshita-Kawada; Junichi Yuasa-Kawada; Kotaro Takasaki; Yoshinari Uehara; Shozo Jinno; Katsunori Iwasaki; Yoshio Tsuboi
Neuroscience Letters, 2018年02月

The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D2 and 5-HT2A receptors: Implications for obsessive–compulsive disorder
Nobuaki Egashira; Naoki Kubota; Yu Goto; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Pharmacology Biochemistry and Behavior, 2018年02月01日, 査読有り

Astrocytes with previous chronic exposure to amyloid β-peptide fragment 1-40 suppress excitatory synaptic transmission.
Kawano H; Oyabu K; Yamamoto H; Eto K; Adaniya Y; Kubota K; Watanabe T; Hirano-Iwata A; Nabekura J; Katsurabayashi S; Iwasaki K
Journal of Neurochemistry, 2017年12月, 査読有り

The Traditional Japanese Herbal Medicine Hachimijiogan Elicits Neurite Outgrowth Effects in PC12 Cells and Improves Cognitive in AD Model Rats via Phosphorylation of CREB
Kaori Kubota; Haruka Fukue; Hitomi Sato; Kana Hashimoto; Aya Fujikane; Hiroshi Moriyama; Takuya Watanabe; Shutaro Katsurabayashi; Mosaburo Kainuma; Katsunori Iwasaki
FRONTIERS IN PHARMACOLOGY, 2017年11月

アリピプラゾール錠・OD錠・散・内服液「ニプロ」のマウスを用いた抗精神病効果の検討
長尾昌紀; 森山博史; 大藪康平; 安谷屋友菜; 胸元 芳; 渡辺拓也; 岩崎克典
新薬と臨床, 2017年06月, 査読有り

Effect of hachimijiogan on memory impairment induced by beta-amyloid combined with cerebral ischemia in rats.
Hiroshi Moriyama; Takayasu Mishima; Mosaburo Kainuma; Takuya Watanabe; Masaki Nagao; Kotaro Takasaki; Kaori Kubota; Shutaro Katsurabayashi; Yoshio Tsuboi; Katsunori Iwasaki
Traditional & Kampo Medicine, 2017年04月03日, 査読有り

Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer's disease rat model
Hiroshi Moriyama; Takuya Watanabe; Kotaro Takasaki; Masaki Nagao; Kaori Kubota; Shutaro Katsurabayashi; Nobuaki Egashira; Katsunori I
Traditional & Kampo Medicine, 2017年04月03日, 査読有り

Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats
Nobuaki Egashira; Hikari Iba; Haruna Kuwano; Rikako Kawanaka; Masaki Nagao; Hiroshi Moriyama; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2016年08月, 査読有り

神経栄養因子の補充療法に替わる抑肝散による認知症治療法の構築
Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Katsunori Iwasaki
BIO Clinica, 2016年04月

アルツハイマー型認知症モデルラットの空間認知障害に対するドネペジルと抑肝散の併用効果
角田菜緒; 長尾昌紀; 森山博史; 呼和哈斯; 古賀冴華; 窪田香織; 渡辺拓也; 桂林秀太郎; 岩崎克典
臨牀と研究, 2016年

Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture
Marta Esteves da Silva; Max Adrian; Philipp Schatzle; Joanna Lipka; Takuya Watanabe; Sukhee Cho; Kensuke Futai; Corette J. Wierenga; Lukas C. Kapitein; Casper C. Hoogenraad
CELL REPORTS, 2015年11月, 査読有り

Nifedipine Prevents Sodium Caprate-Induced Barrier Dysfunction in Human Epidermal Keratinocyte Cultures
Yoshihiro Uchino; Junichi Matsumoto; Takuya Watanabe; Masato Hamabashiri; Takashi Tsuchiya; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2015年06月, 査読有り

Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons
Wenjie Mao; Takuya Watanabe; Sukhee Cho; Jeffrey L. Frost; Tina Truong; Xiaohu Zhao; Kensuke Futai
EUROPEAN JOURNAL OF NEUROSCIENCE, 2015年04月, 査読有り

Tumor necrosis factor-α reduces beta-amyloid accumulation primarily by lowering cellular prion protein levels in a brain endothelial cell line
YASUTAKA Yuki; WATANABE Takuya; NAKASHIMA Akio; Matsumoto Junichi; Fytagami Kojiro; YAMAUCHI Atsushi; KATAOKA Yasufumi
FEBS LETTERS, 2015年01月, 査読有り

Injection of specific amyloid-beta oligomers (beta(1-40):beta(1-42)=10:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis
Mehmet Bulent Ozdemir; Cagdas Erdogan; Katsunori Iwasaki; Takuya Watanabe; Shin Ishikane; Michihiro Fujiwara
NEUROLOGICAL RESEARCH, 2013年10月, 査読有り

Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden
Takuya Watanabe; Kotaro Takasaki; Norito Yamagata; Michihiro Fujiwara; Katsunori Iwasaki
Neuroscience Letters, 2013年03月01日, 査読有り

Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4
渡辺 拓也; 道具 伸也; 高田 芙友子; 中島 章雄; 二神 幸次郎; 山内 淳史; 片岡 泰文
Biological & Pharmaceutical Bulletin, 2013年01月, 査読有り

Atorvastatin stimulates neuroblastoma cells to induce neurite outgrowth by increasing cellular prion protein expression
渡辺 拓也; 中島 章雄; 山内 淳史; 片岡 泰文
Neuroscience letters, 2012年12月07日, 査読有り

Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis
Tsuyoshi Nishioku; Shinya Dohgu; Mitsuhisa Koga; Takashi Machida; Takuya Watanabe; Teppei Miura; Kousuke Tsumagari; Mariko Terasawa; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF INFLAMMATION-LONDON, 2012年11月, 査読有り

Cholinergic Involvement and Synaptic Dynamin 1 Expression in Yokukansan-mediated Improvement of Spatial Memory in a Rat Model of Early Alzheimer's Disease.
Naoki Uchida; Kotaro Takasaki; Yuri Sakata; Ai Nogami; Hiroshi Oishi; Takuya Watanabe; Taro Shindo; Nobuaki Egashira; Kaori Kubota; Shutaro Katsurabayashi; Kenichi Mishima; Michihiro Fujiwara; Ryoji Nishimura; Katsunori Iwasaki
Phytotherapy research, 2012年08月

Involvement of the cellular prion protein in the migration of brain microvascular endothelial cells
Takuya Watanabe; Yuki Yasutaka; Tsuyoshi Nishioku; Sae Kusakabe; Koujiro Futagami; Atsushi Yamauchi; Yasufumi Kataoka
NEUROSCIENCE LETTERS, 2011年06月, 査読有り

Partial hepatectomy aggravates cyclosporin A-induced neurotoxicity by lowering the function of the blood-brain barrier in mice
Atsushi Yamauchi; Shinya Dohgu; Fuyuko Takata; Takuya Watanabe; Tsuyoshi Nishioku; Junich Matsumoto; Yuka Ohkubo; Hideki Shuto; Yasufumi Kataoka
LIFE SCIENCES, 2011年03月, 査読有り

Disruption of the blood-brain barrier in collagen-induced arthritic mice
Tsuyoshi Nishioku; Atsushi Yamauchi; Fuyuko Takata; Takuya Watanabe; Koki Furusho; Hideki Shuto; Shinya Dohgu; Yasufumi Kataoka
NEUROSCIENCE LETTERS, 2010年10月, 査読有り

Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1.
Dohgu S; Takata F; Matsumoto J; Oda M; Harada E; Watanabe T; Nishioku T; Shuto H; Yamauchi A; Kataoka Y
Microvasc Res., 2010年10月, 査読有り

Cyclosporin A induces hyperpermeability of the blood-brain barrier by inhibiting autocrine adrenomedullin-mediated up-regulation of endothelial barrier function
Shinya Dohgu; Noriko Sumi; Tsuyoshi Nishioku; Fuyuko Takata; Takuya Watanabe; Mikihiko Naito; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
EUROPEAN JOURNAL OF PHARMACOLOGY, 2010年10月, 査読有り

Development of an Ultra-Rapid Diagnostic Method Based on Heart-Type Fatty Acid Binding Protein Levels in the CSF of CJD Patients
Yuki Matsui; Katsuya Satoh; Kazuo Mutsukura; Takuya Watanabe; Noriyuki Nishida; Hideo Matsuda; Masaichi Sugino; Susumu Shirabe; Katsumi Eguchi; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2010年10月, 査読有り

Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
Watanabe T; Iwasaki K; Takasaki K; Yamagata N; Fujino M; Nogami A; Ii M; Katsurabayashi S; Mishima K; Fujiwara M
J Neurosci Res., 2010年06月, 査読有り

Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood-Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia
Noriko Sumi; Tsuyoshi Nishioku; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Hideki Shuto; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2010年03月, 査読有り

Disruption of the blood-brain barrier in collagen-induced arthritic mice
Koki Furusho; Tsuyoshi Nishioku; Teppei Miura; Ayano Tomita; Shinya Dohgu; Fuyuko Takata; Takuya Watanabe; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010年, 査読有り

Therapeutic Time Window of Cannabidiol Treatment on Delayed Ischemic Damage via High-Mobility Group Box1-Inhibiting Mechanism
Kazuhide Hayakawa; Keiichi Irie; Kazunori Sano; Takuya Watanabe; Sei Higuchi; Makiko Enoki; Takafumi Nakano; Kazuhiko Harada; Shin Ishikane; Tomoaki Ikeda; Masayuki Fujioka; Kensuke Orito; Katsunori Iwasaki; Kenichi Mishima; Michihiro Fujiwara
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2009年09月, 査読有り

Decreased acetylcholine release as correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease
Takuya Watanabe; Norito Yamagata; Kotaro Takasaki; Kazunori Sano; Kazuhide Hayakawa; Shutaro Katsurabayashi; Nobuaki Egashira; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
BRAIN RESEARCH, 2009年01月, 査読有り

Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats
Takuy Watanabe; Katsunori Iwasaki; Shin Ishikane; Tetsuya Naitou; Yoshitaka Yoshimitsu; Norito Yamagata; Mehmeto Biflent Ozdemir; Kotaro Takasaki; Nobuaki Egashira; Kenichi Mishinia; Michihiro Fujiwara
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008年01月, 査読有り

Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats
Katsunori Iwasaki; Nobuaki Egashira; Izzettin Hatip-Al-Khatib; Yuki Akiyoshi; Takashi Arai; Yuki Takayaki; Takuya Watanabe; Kenichi Mishima; Michihiro Fujiwara
BRAIN RESEARCH, 2006年06月, 査読有り

Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice
N Egashira; K Iwasaki; A Takashima; T Watanabe; H Kawabe; T Matsuda; K Mishima; S Chidori; R Nishimura; M Fujiwara
BRAIN RESEARCH, 2005年10月

Brain pericytes facilitate insulin-induced phosphorylation of Akt in the hypothalamic neuronal cells
Hiroyuki Takahashi; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011年

老化促進モデルマウスの行動変容に対する人参養栄湯の効果～フレイル予防を目指して～
渡辺拓也
第40回和漢医薬学会学術大会, 2023年08月27日

バルプロ酸暴露アストロサイトのシナプス形成・伝達に対する影響
渡辺 拓也; 武田 琴水; 大藪 康平; 内野 鉱也; 窪田 香織; 桂林 秀太郎; 岩崎 克典
日本薬学会第１４２年会, 2022年03月27日, 日本薬学会

易怒性・攻撃性に対して抑制効果を示す漢方薬の作用機序探索
第３８回和漢医薬学会学術大会 学術貢献賞受賞講演, 2021年09月04日, 和漢医薬学会

発達障害で認められる社会性行動障害の治療を目的とした漢方薬の探索
渡辺拓也; 射場日佳里; 松澤香奈絵; 川井 優; 才宮万季; 冨高真弘; 入佐紘司; 窪田香織; 桂林秀太郎; 岩崎克典
生体機能と創薬シンポジウム２０１８, 2018年08月24日, 公益社団法人日本薬学会薬理系薬学部会

アルツハイマー病モデル動物の空間記憶障害における八味地黄丸の効果
渡辺拓也; 岩崎克典
医療薬学フォーラム２０１７, 2017年07月02日, 公益社団法人日本薬学会医療薬科学部会

日本薬理学会

日本小児科学会

Society for Neuroscience

日本神経精神薬理学会

日本薬学会

和漢医薬学会

高齢者疲労感の病態解明を目的とした漢方「補剤」の作用機序研究
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
2023年04月 - 2026年03月

アルツハイマー病の早期嗅覚障害への介入が認知機能障害発症に与える影響の基礎研究
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
2023年04月 - 2026年03月

アンドロゲンシグナルから捉えるCOPD病態の解析と治療薬の探索
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
2022年04月 - 2025年03月

自閉症モデルマウス由来アストロサイトによる興奮性シナプス伝達増強の分子機序解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
2020年04月 - 2023年03月

がん関連疲労に対する漢方補剤の有効性に関する基礎研究
公益財団法人 臨床研究奨励基金, コメディカル臨床研究助成
2021年11月 - 2022年10月

胎児期バルプロ酸暴露誘発自閉症スペクトラム障害におけるアストロサイト分泌因子異常
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
2017年04月 - 2020年03月

尿酸-P2X7受容体-GSK3β経路によるパーキンソン病の発症・進展制御機構
日本学術振興会, 科学研究費助成事業, 基盤研究(Ｃ)
福岡大学
2015年10月 - 2018年03月