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Last Updated :2024/04/12

honda akira

School of Medicine
Lecturer/Senior Assistant Professor

Profile1992-1994 大腸菌蛋白質膜透過因子SecAの機能に関する研究 1994-1998 ヒストン脱アセチル化酵素阻害剤トリコスタチンAを用いた分裂酵母ヒストン脱アセチル化酵素の取得と機能解析 1998-2004 cGMP indicator (Cygnet)の開発とcGMPシグナル伝達系に関する研究 2004-    血管平滑筋細胞に対するcGMPシグナル伝達系が果たす役割の解析

Researcher information

■ Degree
  • 博士(農学), 東京大学
  • Ph.D. (Agriculture), The University of Tokyo
■ Research Keyword
  • vasodilation
  • vascular smooth muscle cell
  • cGMP-dependent protein kinase
  • cGMP
  • intracellular signal transduction
■ Field Of Study
  • Life sciences, Physiology, General Physiology
  • Life sciences, Clinical pharmacy, General Physiology
  • Life sciences, Applied biochemistry, Applied Biochemistry
  • Life sciences, Molecular biology, Molecular Biology

Career

■ Career
  • 01 Oct. 2011
    Assistant Professor
  • 01 Apr. 2007 - 30 Sep. 2011
    Assistant Professor
  • 01 Apr. 2006 - 31 Mar. 2007
    Research Associate
  • 01 Apr. 2005 - 31 Mar. 2006
    Postdoctoral Associate
  • 01 Sep. 2004 - 31 Mar. 2005
    Postdoctoral Associate
  • 01 Jun. 2002 - 31 Aug. 2004
    Research Associate
  • 01 Jul. 1999 - 31 May 2002
    Postdoctoral Associate
  • 16 Mar. 1998 - 30 Jun. 1998
    Psotdoctoral Fellow
  • 01 Apr. 1997 - 15 Mar. 1998
    Postdoctoral Fellow
■ Educational Background
  • Apr. 1994 - Mar. 1997
    The University of Tokyo, 農学生命科学研究科, 応用生命工学専攻

Research activity information

■ Paper
  • Critical Role of TRPC1-Mediated Ca2+ Entry in Decidualization of Human Endometrial Stromal Cells
    Yasuhiro Kawarabayashi; Lin Hai; Akira Honda; Shinji Horiuchi; Hiroshi Tsujioka; Jun Ichikawa; Ryuji Inoue
    MOLECULAR ENDOCRINOLOGY, May 2012, Refereed
  • Counteracting effect of TRPC1-associated Ca2+ influx on TNF-α-induced COX-2-dependent prostaglandin E2 production in human colonic myofibroblasts.
    HAI Lin; KAWARABAYASHI Yasuhiro; IMAI Yuko; HONDA Akira; Inoue Ryuji
    Am J Physiol Gastrointest Liver Physiol., Aug. 2011, Refereed
  • 17β-Estradiol-induced enhancement of estrogen receptor biosynthsis via MAPK pathway in mouse skeletal muscle myoblasts
    HATAE Junna
    J.Physiol Sci, Jan. 2009, Refereed
  • Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6
    Shinichi Takahashi; Hai Lin; Naomi Geshi; Yasuo Mori; Yasuhiro Kawarabayashi; Noboru Takami; Masayuki X. Mori; Akira Honda; Ryuji Inoue
    JOURNAL OF PHYSIOLOGY-LONDON, Sep. 2008, Refereed
  • 心血管TRPチャネルをめぐる病態生理の新展開:心血管リモデリングとTRPチャネル
    井上 隆司; 本田 啓; 海 琳
    蛋白質 核酸 酵素, Jun. 2008
  • Pathophysiological implications of transient receptor potential channels in vascular function
    Ryuji Inoue; Lin Hai; Akira Honda
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, Mar. 2008, Refereed
  • Membrane stretch-induced activation of a TRPM4-like nonselective cation channel in cerebral artery myocytes
    Hiromitsu Morita; Akira Honda; Ryuji Inoue; Yushi Ito; Kihachiro Abe; Mark T. Nelson; Joseph E. Brayden
    JOURNAL OF PHARMACOLOGICAL SCIENCES, Apr. 2007, Refereed
  • Cell membrane-derived lysophosphatidylcholine activates cardiac ryanodine receptor channels
    Yuki Nakamura; Midori Yasukochi; Sei Kobayashi; Kiyoko Uehara; Akira Honda; Ryuji Inoue; Issei Imanaga; Akira Uehara
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Jan. 2007, Refereed
  • Cell membrane-derived lysophosphatidylcholine activates cardiac ryanodine receptor channels
    Yuki Nakamura; Midori Yasukochi; Sei Kobayashi; Kiyoko Uehara; Akira Honda; Ryuji Inoue; Issei Imanaga; Akira Uehara
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Jan. 2007, Refereed
  • Transient receptor potential (TRP) channels in cardiovascular function and disease
    Ryuji Inoue; Lars Jorn Jensen; Juan Shi; Hiromitsu Morita; Motohiro Nishida; Akira honda; Yushi Ito
    Circ. Res., Jul. 2006, Refereed
  • Membrane-permeable cygnets: Rapid cellular internalization of fluorescent cGMP-indicators
    Akira Honda; Markus A. Moosmeier; Wofgang R.G. Dostmann
    Front. Biosci., May 2005, Refereed
  • Emergence of a R-type Ca2+ channel (Ca-V 2.3) contributes to cerebral artery constriction after subarachnoid hemorrhage
    M Ishiguro; TL Wellman; A Honda; Russell, SR; BI Tranmer; GC Wellman
    CIRCULATION RESEARCH, Mar. 2005, Refereed
  • Cygnets: Spatial and temporal analysis of intracellular cGMP
    CL Sawyer; A Honda; WRG Dostmann
    PROCEEDING OF THE FORTY-SIXTH ANNUAL MEETING OF THE WESTERN PHARMACOLOGY SOCIETY, 2003
  • Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator.
    Akira Honda; Stephen R. Adams; Carolyn L. Sawyer; Varda Lev-Ram; Roger Y. Tsien; Wolfgang; R.G.Dostmann
    Proc. Natl. Acad. Sci. USA, Feb. 2001, Refereed
  • phd1(+), a histone deacetylase gene of Schizosaccharomyces pombe, is required for the meiotic cell cycle and resistance to trichostatin A
    YB Kim; A Honda; M Yoshida; S Horinouchi
    FEBS LETTERS, Oct. 1998, Refereed
  • A novel HSP70 gene of Schizosaccharomyces pombe that confers K-252a resistance
    T Usui; M Yoshida; K Kasahara; A Honda; T Beppu; S Horinouchi
    GENE, Apr. 1997, Refereed
  • ヒストン脱アセチル化酵素阻害剤とラディシコールによる腫瘍細胞の形態正常化
    M. Yoshida; A. Honda; S. Horinouchi
    Japanese Journal of Cancer and Chemotherapy, 1997
  • A K-252A-RESISTANCE GENE, SKS1(+), ENCODES A PROTEIN SIMILAR TO THE CAENORHABDITIS-ELEGANS F37 A4.5 GENE-PRODUCT AND CONFERS MULTIDRUG-RESISTANCE IN SCHIZOSACCHAROMYCES-POMBE
    T USUI; M YOSHIDA; A HONDA; T BEPPU; S HORINOUCHI
    GENE, Aug. 1995, Refereed
■ Books and other publications
  • Book Title: Cell Biology Third Edition. Section Title: Cygnets: Intracellular cGMP sensing in primary cells using fluorescence energy transfer.
    Carolyn L. Sawyer; Akira Honda; Wolfgang; R.G.Dostmann, Joint editor, Vol. 2, 299-306
    Elsevier Science (USA), 2006
  • Book title: Methods in Molecular Biology. Section Title: Cygnets: in vitro characterization of novel cGMP indicators and in vivo imaging of intracellular cGMP.
    Akira Honda; Carolyn L. Sawyer; Sharon M. Cawley; Wolfgang; R.G. Dostmann, Joint editor, Vol. 307, 27-43
    Humana Press, 2005
■ Lectures, oral presentations, etc.
  • cGMP依存性キナーゼとTRPC6チャネルとの相互作用に関する構造機能相関の解析
    本田 啓; 井上 隆司
    第91回日本生理学会大会, 17 Mar. 2014
  • cGMP依存性キナーゼのN末領域に存在する酸性アミノ酸はTRPC6との相互作用に必須である
    本田 啓; 井上 隆司
    第90回日本生理学会大会, 29 Mar. 2013
  • PKGIbetaとTRPC6との相互作用に寄与する両蛋白質内のアミノ酸の同定
    本田 啓; 井上 隆司
    2013年度日本農芸化学会大会, 26 Mar. 2013
  • TRPC6チャネルを制御するI型cGMP依存性キナーゼのTRPC6相互作用部位の解明
    本田 啓; 井上 隆司
    第22回日本循環薬理学会, 30 Nov. 2012
  • マウス骨格筋のestrogen receptorとGPR30に及ぼすestrogenの作用
    HATAE Junna; TAKAMI Noboru; HONDA Akira; INOUE Ryuji
    第89回日本生理学会大会, 29 Mar. 2012
  • I型cGMP依存性キナーゼのロイシンジッパー領域を介したTRPC6との相互作用の解明
    HONDA Akira; INOUE Ryuji
    第89回日本生理学会大会, 29 Mar. 2012
  • I型cGMP依存性キナーゼによるTRPC6チャネルの制御機構に関する構造機能解析
    HONDA Akira; INOUE Ryuji
    2012年度日本農芸化学会大会, 22 Mar. 2012
  • Actions of estrogen on nuclear and cell membrane estrogen receptors in mouse myoblastic and myotubic skeletal muscle cells
    HATAE Junna; TAKAMI Noboru; HONDA Akira; INOUE Ryuji
    The 10th Korea-Japan Joint Symposium of Brain, Sciences, and Cardiac and Smooth Muscle Sciences, 17 Feb. 2012
  • Myotubeに及ぼすエストロゲンの作用
    HATAE Junna; TAKAMI Noboru; HONDA Akira; INOUE Ryuji
    筋生理の集い, 17 Dec. 2011
  • I型cGMP依存性キナーゼはサブタイプ特異的な方法でTRPC6のN末領域と相互作用する
    Akira Honda; Zhong Jian; Lin Hai; Ryuji Inoue
    The joint meeting of the 88th annual meeting of the Physiological Society of Japan & the 116th annual meeting of the Japanese Association of Anatomists, 28 Mar. 2011
  • I型cGMP依存性キナーゼのC末領域は基質結合に対するcGMP依存性に寄与している
    本田 啓; 井上 隆司
    2011年度日本農芸化学会大会, 27 Mar. 2011
  • Analysis of the interaction between TRPC6 and PKG type I by site directed mutagenesis
    Akira Honda; Ryuji Inoue
    The 9th Japan-Korea Symposium, 25 Nov. 2010
  • TRPC6チャネルN末領域に存在するI型PKGとの相互作用部位の探索
    本田 啓; 菅 忠; 井上 隆司
    第61回西日本生理学会, 16 Oct. 2010
  • TRPC6チャネル蛋白質とその負の制御因子であるI型PKGとの相互作用に関する研究
    本田 啓; 菅 忠; 海 琳; 井上 隆司
    第9回九州脳と高血圧研究会, 24 Jul. 2010
  • TRPC6のN末136アミノ酸領域はI型PKGとの相互作用に寄与している
    本田 啓; 菅 忠; 倉原(海) 琳; 高橋 眞一; 井上 隆司
    The 87th annual meeting of the Physiological Society of Japan, 19 May 2010
  • TRPチャネル蛋白質のN末領域におけるI型cGMP依存性キナーゼとの相互作用部位の同定
    本田 啓; 菅 忠; 海 琳; 高橋 眞一; 井上 隆司
    2010年度日本農芸化学会大会, 29 Mar. 2010
  • NO/cGMP/PKGによる血管受容体作動性TRPC6チャネルの活性化調節分子機構
    海 琳; 菅 忠; 高橋 眞一; 本田 啓; 森 誠之; 井上 隆司
    第19回日本循環薬理学会, 27 Nov. 2009
  • ヒト子宮内膜の脱落膜化過程におけるTRPC1を介したCa2+流入の促進効果
    瓦林 靖広; 海 琳; 本田 啓; 森 誠之; 井上 隆司
    第60回西日本生理学会, 06 Nov. 2009
  • Counteracting effect of TRPC1-associated store-operated Ca2+ influx on TNF-alpha induced PGE2 production in human colonic myofibroblast
    Lin Hai; Yasuhiro Kawarabayashi; Akira Honda; Ryuji Inoue
    36th International Congress of Physiological Sciences, 29 Jul. 2009
  • PKG type I negatively regulates TRPC6 by phosphorylation through interaction with TRPC6 N terminal domain
    Akira Honda; Zhong Jian; Lin Hai; Shinichi Takahashi; Ryuji Inoue
    36th International Congress of Physiological Sciences, 28 Jul. 2009
  • 骨格筋におけるエストラジオールの作用とエストロゲンレセプター
    HATAE Junna; TAKAMI Noboru; Hai lin; HONDA Akira; INOUE Ryuji
    筋生理の集い, 13 Dec. 2008
  • 心血管受容体作動性Ca2+チャネルTRPC6とその負の制御因子PKGとの相互作用の検討
    本田 啓; 菅 忠; 海 琳; 高橋 眞一; 井上 隆司
    第18回日本循環薬理学会, 21 Nov. 2008
  • Genomic and non-genomic action of estrogen in the mouse skeletal muscle cells
    HATAE Junna; TAKAMI Noboru; Hai lin; HONDA Akira; INOUE Ryuji
    The 85th Annual meeting of the Physiological Society of Japan, 25 Mar. 2008
  • 血管受容体作動性CaチャネルTRPC6の受容体・機械刺激による層状活性化機構
    井上 隆司; 瓦林 靖広; 高橋 眞一; 海 琳; 森 誠之; 本田 啓
    第85回日本生理学会大会, 25 Mar. 2008
  • ヒト消化管筋線維芽細胞CCD-18CoのTNFα刺激によるTRPC1の発現増加およびストア依存性Ca2+流入の促進
    海 琳; 瓦林 靖広; 本田 啓; 井上 隆司
    第85回日本生理学会大会, 25 Mar. 2008
  • エストロゲンの骨格筋におけるゲノミック作用とノンゲノミック作用
    HATAE Junna; TAKAMI Noboru; Hai lin; HONDA Akira; INOUE Ryuji
    筋生理の集い, 15 Dec. 2007
  • Development and characterization of membrane-permeable fluorescent cGMP-indicators
    Akira Honda; Wolfgang; R.G. Dostmann; Ryuji Inoue
    Fifth United States-Japan Workshop on Cellular and Molecular Aspects of Vascular Smooth Muscle Function, 07 Jan. 2007
  • Regulation and function of vascular TRP cation channel
    Inoue R; Takahashi S; Kawarabayashi Y; Nakamura Y; Honda A; Lin H; Uehara A
    Federation of Asian and Oceanian Physiological Societies (FAOPS) 2006, Symposium, 14 Oct. 2006
  • Membrane permeable Cygnets: rapid cellular internalization of fluorescent cGMP-indicators
    Akira Honda; Markus A. Moosmeier; Wolfgang R.G. Dostmann
    14th Protein Kinase Symposium, 23 Sep. 2004
  • Novel in vivo fluorescent cGMP indicators using FRET
    Akira Honda; C.L. Ellenberger; C.Y. Cho; S.R. Adams; R.Y. Tsien; W.R.G. Dostmann
    Biophysical Meeting, 12 Feb. 2000
■ Affiliated academic society
  • Physiological Society of Japan
  • The Japanese Pharmacological Society
  • Biophysical Society
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • Japanese Association of Cardiovascular Pharmacology