ARP-1 regulates the transcriptional activity of the aromatase gene in the mouse brain
Honda S; Harada N
Front. Endocrinol (Lausanne), 2020, Refereed

Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities
Eiji Nishio; Takanori Hayashi; Masashi Nakatani; Noriko Aida; Risa Suda; Takuma Fujii; Toru Wakatsuki; Shin-ichiro Honda; Nobuhiro Harada; Yohei Shimono
Biochem. Biophys. Rep., 2019, Refereed

Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters
Kurokawa, J; Sasano, T; Kodama, M; Li, M; Ebana, Y; Harada, N; Honda, S; Nakaya, H; Furukawa, T
J. Toxicol. Sci., 2015, Refereed

LIM-Homeodomain Transcription Factor, Lhx2, is involved in Transcriptional Control of Brain-Specific Promoter/Exon 1f of the Mouse Aromatase Gene
S. Honda; T. Kozako; H. Shimeno; S. Soeda; N. Harada
JOURNAL OF NEUROENDOCRINOLOGY, Nov. 2012, Refereed

Estradiol Promotes Purkinje Dendritic Growth, Spinogenesis, and Synaptogenesis During Neonatal Life by Inducing the Expression of BDNF
Shogo Haraguchi; Katsunori Sasahara; Hanako Shikimi; Shin-ichiro Honda; Nobuhiro Harada; Kazuyoshi Tsutsui
CEREBELLUM, Jun. 2012, Refereed

Vasohibin induces prolyl hydroxylase-mediated degradation of hypoxia-inducible factor-1 alpha in human umbilical vein endothelial cells
Tomohiro Kozako; Noriko Matsumoto; Yukako Kuramoto; Akira Sakata; Rie Motonagare; Akiyoshi Aikawa; Masumi Imoto; Akihisa Toda; Shin-ichiro Honda; Hiroshi Shimeno; Shinji Soeda
FEBS LETTERS, Apr. 2012, Refereed

High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells
Kozako, T; Aikawa, A; Shoji, T; Fujimoto, T; Yoshimitsu, M; Shirasawa, S; Tanaka, H; Honda, S; Shimeno, H; Arima, N; Soeda, S
Int J Cancer, 2012, Refereed

Liposomes and nanotechnology in drug development: focus on oncotargets
Tomohiro Kozako; Naomichi Arima; Makoto Yoshimitsu; Shin-Ichro Honda; Shinji Soeda
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, Refereed

Estradiol promotes purkinje dendritic growth, spinogenesis, and synaptogenesis during neonatal life by inducing the expression of BDNF
Haraguchi, S; Sasahara, K; Shikimi, H; Honda, S; Harada, N; Tsutsui, K
Cerebellum, 2011, Refereed

Behavioral analysis of genetically modified mice indicates essential roles of neurosteroidal estrogen
Honda, S; Wakatsuki, T; Harada, N
Frontiers in endocrinology, 2011, Refereed

Fasting promotes the expression of SIRT1, an NAD(+)-dependent protein deacetylase, via activation of PPAR alpha in mice
Satoru Hayashida; Akie Arimoto; Yukako Kuramoto; Tomohiro Kozako; Shin-ichiro Honda; Hiroshi Shimeno; Shinji Soeda
MOLECULAR AND CELLULAR BIOCHEMISTRY, Jun. 2010, Refereed

Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates beta-Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment
Carrie McAllister; Jiangang Long; Adrienne Bowers; Aaron Walker; Philip Cao; Shin-Ichiro Honda; Nobuhiro Harada; Matthias Staufenbiel; Yong Shen; Rena Li
JOURNAL OF NEUROSCIENCE, May 2010, Refereed

The Androgen Receptor Governs the Execution, but Not Programming, of Male Sexual and Territorial Behaviors
Scott A. Juntti; Jessica Tollkuhn; Melody V. Wu; Eleanor J. Fraser; Taylor Soderborg; Stella Tan; Shin-ichiro Honda; Nobuhiro Harada; Nirao M. Shah
NEURON, Apr. 2010, Refereed

Estrogen Masculinizes Neural Pathways and Sex-Specific Behaviors
Melody V. Wu; Devanand S. Manoli; Eleanor J. Fraser; Jennifer K. Coats; Jessica Tollkuhn; Shin-Ichiro Honda; Nobuhiro Harada; Nirao M. Shah
CELL, Oct. 2009, Refereed

Regulation of progestin receptors in medial amygdala: Estradiol, phytoestrogens and sex
A. E. Kudwa; N. Harada; S. -I. Honda; E. F. Rissman
PHYSIOLOGY & BEHAVIOR, May 2009, Refereed

Functional analysis of neurosteroidal oestrogen using gene-disrupted and transgenic mice
Harada N; Wakatsuki T; Aste N; Yoshimura N; Honda S
J. Neuroendocrinol., 2009, Refereed

Acute effects of oestrogen on the guinea pig and human I-Kr channels and drug-induced prolongation of cardiac repolarization
Junko Kurokawa; Masaji Tamagawa; Nobuhiro Harada; Shin-ichiro Honda; Chang-Xi Bai; Haruaki Nakaya; Tetsushi Furukawa
JOURNAL OF PHYSIOLOGY-LONDON, Jun. 2008, Refereed

Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease?
M. C. Morale; F. L'Episcopo; C. Tirolo; G. Giaquinta; S. Caniglia; N. Testa; P. Aycieri; P. -A. Serra; G. Lupo; M. Alberghina; N. Harada; S. Honda; G. C. Panzica; Bianca Marchetti
BRAIN RESEARCH REVIEWS, Mar. 2008, Refereed

Effects of organisational oestradiol on adult immunoreactive oestrogen receptors (alpha and beta) in the male mouse brain
A. E. Kudwa; N. Harada; S.-I. Honda; E. F. Rissman
JOURNAL OF NEUROENDOCRINOLOGY, Oct. 2007, Refereed

Mode of action and functional significance of estrogen-inducing dendritic growth, spinogenesis, and synaptogenesis in the developing purkinje cell
Katsunori Sasahara; Hanako Shikimi; Shogo Haraguchi; Hirotaka Sakamoto; Shin-ichiro Honda; Nobuhiro Harada; Kazuyoshi Tsutsui
JOURNAL OF NEUROSCIENCE, Jul. 2007, Refereed

Impairment of spatial learning by estradiol treatment in female mice is attenuated by estradiol exposure during development
Imwalle D. B; Bateman H. L; Wills A; Honda S; Harada N; Rissman E. F
Horm. Behav., 2006, Refereed

Brain estrogen deficiency accelerates A beta plaque formation in an Alzheimer's disease animal model
Yue, X; M Lu; T Lancaster; P Cao; SI Honda; M Staufenbiel; N Harada; ZY Zhong; Y Shen; RN Li
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2005, Refereed

Analysis of spatiotemporal regulation of aromatase in the brain using transgenic mice
N Harada; SI Honda
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, May 2005, Refereed

Lack of estrogen increases pain in the trigeminal formalin model: a behavioural and immunocytochemical study of transgenic ArKO mice
S Multon; A Pardutz; J Mosen; MT Hua; C Defays; SI Honda; N Harada; C Bohotin; R Franzen; J Schoenen
PAIN, Mar. 2005, Refereed

Estrogen receptor-independent catechol estrogen binding activity: Protein binding studies in wild-type, estrogen receptor-alpha KO, and aromatase KO mice tissues
BJ Philips; PJ Ansell; LG Newton; N Harada; SI Honda; VK Ganjam; GE Rottinghaus; WV Welshons; DB Lubahn
BIOCHEMISTRY, Jun. 2004, Refereed

Relationships between aromatase activity in the brain and gonads and behavioural deficits in homozygous and heterozygous aromatase knockout mice
Bakker J; Baillien M; Honda S; Harada N; Balthazart J
J. Neuroendocrinol., 2004, Refereed

Restoration of male sexual behavior by adult exogenous estrogens in male aromatase knockout mice
Bakker J; Honda S; Harada N; Balthazart J; Philips B. J; Ansell P. J; Newton L. G; Harada N; Honda S; Ganjam V.K; Rottinghaus G.E; Welshons W.V; Lubahn D.B
Horm. Behav., 2004, Refereed

Unique regulation of expression of human aromatase in the placenta
N Harada; N Yoshimura; S Honda
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Sep. 2003, Refereed

Alteration in sex-specific behaviors in male mice lacking the aromatase gene
T Matsumoto; S Honda; N Harada
NEUROENDOCRINOLOGY, Jun. 2003, Refereed

Forebrain Fos responses to reproductively related chemosensory cues in aromatase knockout mice
N Aste; S Honda; N Harada
BRAIN RESEARCH BULLETIN, May 2003, Refereed

The aromatase knockout (ArKO) mouse provides new evidence that estrogens are required for the development of the female brain
Ann. N. Y. Acad. Sci., 2003, Refereed

遺伝子破壊および改変マウスを用いたアロマターゼ発現調節機構、生理作用の解析
性差医学, 2003

発生工学的手法を用いた脳アロマターゼ遺伝子発現の解析
ホルモンと臨床, 2003

Changes in the arginine-vasopressin immunoreactive systems in male mice lacking a functional aromatase gene
L Plumari; C Viglietti-Panzica; F Allieri; S Honda; N Harada; P Absil; J Balthazart; GC Panzica
JOURNAL OF NEUROENDOCRINOLOGY, Dec. 2002, Refereed

The aromatase knock-out mouse provides new evidence that estradiol is required during development in the female for the expression of sociosexual behaviors in adulthood
J Bakker; SI Honda; N Harada; J Balthazart
JOURNAL OF NEUROSCIENCE, Oct. 2002, Refereed

Sexual partner preference requires a functional aromatase (Cyp19) gene in male mice
J Bakker; S Honda; N Harada; J Balthazart
HORMONES AND BEHAVIOR, Sep. 2002, Refereed

Estrogen-dependent regulation of the expression of hepatic Cyp2b and 3a isoforms: Assessment using aromatase-deficient mice
H Yamada; N Gohyama; S Honda; T Hara; N Harada; K Oguri
TOXICOLOGY AND APPLIED PHARMACOLOGY, Apr. 2002, Refereed

Analysis of transcriptional regulation of human breast aromatase by in vitro and in vivo studies
N Harada; T Matsumoto; N Yoshimura; H Sakamoto; S Honda
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Dec. 2001, Refereed

Characterization and purification of a protein binding to the cis-acting element for brain-specific exon 1 of the mouse aromatase gene
SI Honda; T Matsumoto; N Harada
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Dec. 2001, Refereed

Brain aromatase is neuroprotective
Azcoitia, I; A Sierra; S Veiga; S Honda; N Harada; LM Garcia-Segura
JOURNAL OF NEUROBIOLOGY, Jun. 2001, Refereed

雌型性行動中枢制御の性分化におけるアロマターゼの役割
本田 伸一郎; 松本 高広; 原田 信広
ホルモンと臨床, 2001

A GCM motif protein is involved in placenta-specific expression of human aromatase gene
K Yamada; H Ogawa; S Honda; N Harada; T Okazaki
JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 1999, Refereed

Aromatase inhibitors and enzyme stability
N Harada; SI Honda; O Hatano
ENDOCRINE-RELATED CANCER, Jun. 1999, Refereed

Identification of cis-acting elements in the proximal promoter region for brain-specific exon 1 of the mouse aromatase gene
S Honda; N Harada; S Abe-Dohmae; Y Takagi
MOLECULAR BRAIN RESEARCH, Mar. 1999, Refereed

Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene
S Honda; N Harada; S Ito; Y Takagi; S Maeda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1998, Refereed

Molecular analysis of aberrant expression of aromatase in breast cancer tissues
Breast Cancer Res. Treat., 1998, Refereed

Deamination of amphetamines by cytochromes P450: studies on substrate specificity and regioselectivity with microsomes and purified CYP2C subfamily isozymes
J. Toxicol. Sci., 1997, Refereed

The alternative exon 1 of the mouse aromatase cytochrome P-450 gene
Biochem. Biophys. Res. Commun., 1996, Refereed

CONTRIBUTION OF AD4BP, A STEROIDOGENIC CELL-SPECIFIC TRANSCRIPTION FACTOR, TO REGULATION OF THE HUMAN CYP11A AND BOVINE CYP11B GENES THROUGH THEIR DISTAL PROMOTERS
K TAKAYAMA; K MOROHASHI; S HONDA; N HARA; T OMURA
JOURNAL OF BIOCHEMISTRY, Jul. 1994, Refereed

FUNCTIONAL DIFFERENCE BETWEEN AD4BP AND ELP, AND THEIR DISTRIBUTIONS IN STEROIDOGENIC TISSUES
K MOROHASHI; H IIDA; M NOMURA; O HATANO; S HONDA; T TSUKIYAMA; O NIWA; T HARA; A TAKAKUSU; Y SHIBATA; T OMURA
MOLECULAR ENDOCRINOLOGY, May 1994, Refereed

AD4BP REGULATING STEROIDOGENIC P-450 GENE IS A MEMBER OF STEROID-HORMONE RECEPTOR SUPERFAMILY
S HONDA; K MOROHASHI; M NOMURA; H TAKEYA; M KITAJIMA; T OMURA
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 1993, Refereed

ctivation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP
Mol. Endocrinol., 1993, Refereed

A COMMON TRANS-ACTING FACTOR, AD4-BINDING PROTEIN, TO THE PROMOTERS OF STEROIDOGENIC P-450S
K MOROHASHI; S HONDA; Y INOMATA; H HANDA; T OMURA
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1992, Refereed

Cooperative transcription activation between Ad1, a CRE-like element, and the other elements in the CYP11B gene promoter
J. Biochem., 1992, Refereed

NOVEL CAMP REGULATORY ELEMENTS IN THE PROMOTER REGION OF BOVINE P-450(11-BETA) GENE
SI HONDA; KI MOROHASHI; T OMURA
JOURNAL OF BIOCHEMISTRY, Dec. 1990, Refereed

Structural analysis of multiple bovine P-450(11β) genes and their promoter activities
Kirita S; Hashimoto T; Kitajima M; Honda S; Morohashi K; Omura T
J. Biochem., 1990, Refereed

Rabbit liver constitutive form of cytochrome P-450 responsible for amphetamine deamination
Yamada H; Honda S; Oguri K; Yoshimura H
Arch. Biochem. Biophys., 1989, Refereed

BRAIN AROMATASE ESTROGENS AND BEHAVIOR Molecular Mechanisms Controlling Brain Aromatase Expression
Joint work, Chapter 8
OXFORD UNIVERSITY PRESS, 2012

「臨床検査学」講義での基礎科目との繋がりを意識させることを目指したジグソー法の取り組み
KOZAKO Tomohiro; TONE Nanako; FUJIOKA Toshihiro; YOSHIDA Hideyuki; HONDA Shinichiro; HASHIBA Ron
第5回日本薬学教育学会大会, 12 Sep. 2020

Deaf1タンパク質の機能ドメインの解析
本田伸一郎; 原田信広; 小迫知弘; 相川晃慶; 坂田晃; 添田秦司
第１３４回日本薬学会年会, 30 Mar. 2014

アロマターゼの脳特異的発現に関与する転写因子Deaf-1の機能ドメインの解析
本田伸一郎; 大下遥子; 民本愛; 小迫知弘; 蔵元佑嘉子; 元流梨恵; 原田信広; 添田秦司
第８５回日本生化学会大会, 16 Dec. 2012

サフラン成分クロシンによるレドックス制御
中山 利香; 本田 伸一郎; 小迫 知弘; 藏元 佑嘉子; 元流 梨恵; 正山 征洋; 田中 宏幸; 占野 廣司; 添田 秦司
第２７回日本薬学会九州支部会, 11 Dec. 2011

サフラン成分クロシンの神経細胞死抑制効果
中山利香; 本田伸一郎; 小迫知弘; 蔵元佑嘉子; 元流梨恵; 田中宏幸; 正山征洋; 添田秦司; 占野廣司
第19回ステロイドホルモン学会, 26 Nov. 2011

発生工学的手法を用いた脳内アロマターゼの機能解析
民本愛; 本田伸一郎; 小迫知弘; 蔵元佑嘉子; 元流梨恵; 原田信広; 添田秦司; 占野廣司
第３９回薬物活性シンポジウム, 21 Nov. 2011

アロマターゼの脳特異的プロモーター結合因子の解析
大下遥子; 本田伸一郎; 小迫知弘; 蔵元佑嘉子; 元流梨恵; 原田信広; 添田秦司; 占野廣司
第３９回薬物活性シンポジウム, 21 Nov. 2011

脳特異的なアロマターゼ発現に関与するDeaf-1タンパク質の機能解析
原口美紀; 古田展也; 安田千穂; 本田伸一郎; 小迫知弘; 蔵元佑嘉子; 元流梨恵; 原田信広; 占野廣司; 添田秦司
平成23年度日本生化学会九州支部例会, 22 May 2011

ガンの予防および治療における民間伝承植物の効果検討
今村 翔; 蔵元 佑嘉子; 小迫 知弘; 元流 梨恵; 本田 伸一郎; 占野 廣司; 添田 秦司
第２７回日本薬学会九州支部会, 12 Dec. 2010

NAD依存性脱アセチル化酵素SIRT1及び転写因子FOXO1による筋細胞の分化制御
野見山 融; 小迫 知弘; 藏元 佑嘉子; 元流 梨恵; 本田 伸一郎; 占野 廣司; 添田 秦司
第２７回日本薬学会九州支部会, 12 Dec. 2010

転写因子Deaf-1の転写制御メカニズムの解析
安田 千穂; 本田 伸一郎; 小迫 知弘; 蔵元 佑嘉子; 元流 梨恵; 原田 信広; 添田 秦司; 占野 廣司
第２７回日本薬学会九州支部会, 12 Dec. 2010

アロマターゼの脳特異的プロモーターに作用する転写因子Deaf-1の機能ドメインの解析
安田千穂; 本田伸一郎; 小迫知弘; 藏元佑嘉子; 原田信広; 添田秦司; 占野廣司
第18回日本ステロイドホルモン学会, 27 Nov. 2010

カロリー制限および運動がもたらす生体への影響と骨格筋における長寿関連因子SIRT1 の役割
林田 諭; 藏元佑嘉子; 野見山 融; 古市佳奈; 小迫知弘; 本田伸一郎; 添田秦司; 占野廣司
第26回日本薬学会九州支部大会, 2009

成人T細胞白血病発症における長寿遺伝子の発現と制御
相川 晃慶; 小迫 知弘; 林田 諭; 藏元 佑嘉子; 元流 梨恵; 本田 伸一郎; 鈴木 紳介; 魚住 公治; 吉満 誠; 有馬 直道; 占野 廣司; 添田 秦司
第26回日本薬学会九州支部大会, 2009

白血病細胞における長寿遺伝子SIRT1 阻害剤によるアポトーシスの誘導
荘司 晃寿; 小迫 知弘; 林田 諭; 藏元 佑嘉子; 元流 梨恵; 本田 伸一郎; 吉満 誠; 有馬 直道; 添田 秦司; 占野 廣司
第26回日本薬学会九州支部大会, 2009

成人T細胞白血病発症における長寿遺伝子SIRT1の発現
相川 晃慶; 小迫 知弘; 林田 諭; 藏元 佑嘉子; 元流 梨恵; 本田 伸一郎; 鈴木 伸介; 魚住 公治; 吉満 誠; 有馬 直道; 占野 廣司; 添田 秦司
第2回HTLV-1研究会, 2009

HTLV-1感染細胞株における長寿遺伝子SIRT1阻害剤によるアポトーシス誘導
荘司 晃寿; 小迫 知弘; 林田 諭; 藏元 佑嘉子; 元流 梨恵; 本田 伸一郎; 吉満 誠; 有馬 直道; 添田 秦司; 占野 廣司
第2回HTLV-1研究会, 2009

Analysis of functional domain of Deaf1 protein for the activation of the brain-specific aromatase gene expression
Shin-ichiro Honda; Chiho Yasuda; Nobuhiro Harada; Hiroshi Shimeno; Shinji Soeda
The 32nd Annual Meeting of the Molecular Biology Society of Japan, 2009

プロテオミクスを利用した脳特異的アロマターゼ遺伝子発現を制御するタンパク質の解析
基盤研究(C)
2014 - 2016

脳特異的なアロマターゼ遺伝子発現を制御する転写因子の機能解析
基盤研究(C)
2011 - 2013

脳特異的なアロマターゼ遺伝子発現による脳の性的二型決定機構の解析
基盤研究(C)
2007 - 2009

発生工学的に作成したヒト型エストロゲン代謝異常マウスの内分泌学的解析
基盤研究(C)
2004 - 2005

発生工学的手法を用いた脳内アロマターゼの機能に関する研究
若手研究(B)
2002 - 2004

エストロゲン依存性癌におけるエストロゲン生合成と代謝に関する研究
基盤研究(C)
2002 - 2004

エストロゲン依存性癌のがん化防御に関する研究
特定領域研究(C)
2000 - 2004

発生工学的手法を用いたアロマターゼの機能と発現調節に関する研究
奨励研究(A)
2000 - 2001

発生工学的手法による加齢関連疾患におけるアロマターゼ・エストロゲン系の解析
基盤研究(B)
1999 - 2001

遺伝子破壊マウスを用いたアロマターゼの生理機能に関する研究
奨励研究(A)
1998 - 1999

胎盤形成に必要な遺伝子の発現に関する研究
基盤研究(C)
1996 - 1997

中枢神経系の性分化におけるアロマタ-ゼの機能に関する研究
奨励研究(A)
1996 - 1996

中枢神経系の性分化におけるアロマタ-ゼの機能に関する分子遺伝学的研究
奨励研究(A)
1995 - 1995

脳の性分化におけるアロマタ-ゼの機能に関する分子遺伝学的研究
奨励研究(A)
1994 - 1994