Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes.
Hideaki Tagashira; Md Shenuarin Bhuiyan; Yasuharu Shinoda; Ichiro Kawahata; Tomohiro Numata; Kohji Fukunaga
Journal of pharmacological sciences, 2023年02月

Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin.
Kazuya Matsuo; Yasuharu Shinoda; Nona Abolhassani; Yusaku Nakabeppu; Kohji Fukunaga
Frontiers in psychiatry, 2022年

Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress.
An Cheng; Yi-Fei Wang; Yasuharu Shinoda; Ichiro Kawahata; Tetsunori Yamamoto; Wen-Bin Jia; Hanae Yamamoto; Tomohiro Mizobata; Yasushi Kawata; Kohji Fukunaga
Acta pharmacologica Sinica, 2021年05月02日

Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress
Yifei Wang; Yasuharu Shinoda; An Cheng; Ichiro Kawahata; Kohji Fukunaga
Biomedicines, 2021年01月22日, 査読有り

An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3
Naoya Fukui; Hanae Yamamoto; Moe Miyabe; Yuki Aoyama; Kunihiro Hongo; Tomohiro Mizobata; Ichiro Kawahata; Yasushi Yabuki; Yasuharu Shinoda; Kohji Fukunaga; Yasushi Kawata
Journal of Biological Chemistry, 2021年01月

T-type Ca²⁺ channel enhancer SAK3 administration improves the BPSD-like behaviors in App^{NL−G-F/NL−G-F} knock-in mice
Degawa, T.; Kawahata, I.; Izumi, H.; Shinoda, Y.; Fukunaga, K.
Journal of Pharmacological Sciences, 2021年, 査読有り

Ligand Bound Fatty Acid Binding Protein 7 (FABP7) Drives Melanoma Cell Proliferation Via Modulation of Wnt/β-Catenin Signaling
Umaru, B.A.; Kagawa, Y.; Shil, S.K.; Arakawa, N.; Pan, Y.; Miyazaki, H.; Kobayashi, S.; Yang, S.; Cheng, A.; Wang, Y.; Shinoda, Y.; Kiniwa, Y.; Okuyama, R.; Fukunaga, K.; Owada, Y.
Pharmaceutical Research, 2021年, 査読有り

Wildtype σ1 receptor and the receptor agonist improve ALS-associated mutation-induced insolubility and toxicity
Yasuharu Shinoda; Yudai Haga; Koichiro Akagawa; Kohji Fukunaga
Journal of Biological Chemistry, 2020年12月18日, 査読有り
筆頭著者

Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA(A)Receptor
Yasushi Yabuki; Jiaqi Liu; Ichiro Kawahata; Hisanao Izumi; Yasuharu Shinoda; Kohei Koga; Shinya Ueno; Norifumi Shioda; Kohji Fukunaga
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020年08月, 査読有り

Analysis of binding affinity and docking of novel fatty acid-binding protein (FABP) ligands
Yasuharu Shinoda; Yifei Wang; Tetsunori Yamamoto; Hiroyuki Miyachi; Kohji Fukunaga
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2020年08月, 査読有り
筆頭著者

SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App(NL-G-F/NL-G-F) Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling
Hisanao Izumi; Ichiro Kawahata; Yasuharu Shinoda; Fred J. Helmstetter; Kohji Fukunaga
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020年06月, 査読有り

Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice
Hidaka Haga; Ryo Yamada; Hisanao Izumi; Yasuharu Shinoda; Ichiro Kawahata; Hiroyuki Miyachi; Kohji Fukunaga
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2020年04月, 査読有り

Crucial Role of Dopamine D2 Receptor Signaling in Nicotine-Induced Conditioned Place Preference
Gofarana Wilar; Yasuharu Shinoda; Toshikuni Sasaoka; Kohji Fukunaga
MOLECULAR NEUROBIOLOGY, 2019年12月, 査読有り

Discovery of disease-modifying drug inhibiting alpha-synuclein aggregation in Lewy body dementia
Kohji Fukunaga; Kazuya Matsuo; An Cheng; Yasuharu Shinoda
IBRO Reports, 2019年09月

Combined citicoline and docosahexaenoic acid treatment improves cognitive dysfunction following transient brain ischemia
Efi Nakazaki; Yasushi Yabuki; Hisanao Izumi; Yasuharu Shinoda; Fumiko Watanabe; Yukihiro Hishida; Ayako Kamimura; Kohji Fukunaga
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2019年04月, 査読有り

Development of FABP3 ligands that inhibit arachidonic acid-induced alpha-synuclein oligomerization
An Cheng; Yasuharu Shinoda; Tetsunori Yamamoto; Hiroyuki Miyachi; Kohji Fukunaga
BRAIN RESEARCH, 2019年03月, 査読有り

KY-226 Protects Blood-brain Barrier Function Through the Akt/FoxO1 Signaling Pathway in Brain Ischemia
Meiling Sun; Yasuharu Shinoda; Kohji Fukunaga
NEUROSCIENCE, 2019年02月, 査読有り

Neuroprotective effects of protein tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice
Meiling Sun; Hisanao Izumi; Yasuharu Shinoda; Kohji Fukunaga
BRAIN RESEARCH, 2018年09月, 査読有り

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in &ITApp&IT Knock-in Mice
Hisanao Izumi; Yasuharu Shinoda; Takashi Saito; Takaomi C. Saido; Keita Sato; Yasushi Yabuki; Yotaro Matsumoto; Yoshitomi Kanemitsu; Yoshihisa Tomioka; Nona Abolhassani; Yusaku Nakabeppu; Kohji Fukunaga
NEUROSCIENCE, 2018年05月, 査読有り

Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect
Satoru Tamura; Maiko Okada; Shigeaki Kato; Yasuharu Shinoda; Norifumi Shioda; Kohji Fukunaga; Kumiko Ui-Tei; Minoru Ueda
SCIENTIFIC REPORTS, 2018年02月, 査読有り

Acute Treatment with T-Type Calcium Channel Enhancer SAK3 Reduces Cognitive Impairments Caused by Methimazole-Induced Hypothyroidism Via Activation of Cholinergic Signaling
Noreen Husain; Yasushi Yabuki; Yasuharu Shinoda; Kohji Fukunaga
PHARMACOLOGY, 2018年, 査読有り

Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain
Gofarana Wilar; Kusnandar Anggadiredja; Yasuharu Shinoda; Kohji Fukunaga
PHARMACOLOGY, 2018年, 査読有り

trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway
Yusuke Hirata; Miki Takahashi; Yuki Kudoh; Kuniyuki Kano; Hiroki Kawana; Kumiko Makide; Yasuharu Shinoda; Yasushi Yabuki; Kohji Fukunaga; Junken Aoki; Takuya Noguchi; Atsushi Matsuzawa
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017年05月, 査読有り

Combined Memantine and Donepezil Treatment Improves Behavioral and Psychological Symptoms of Dementia-Like Behaviors in Olfactory Bulbectomized Mice
Yasushi Yabuki; Kazuya Matsuo; Koga Hirano; Yasuharu Shinoda; Shigeki Moriguchi; Kohji Fukunaga
PHARMACOLOGY, 2017年, 査読有り

Corticosteroids Mediate Heart Failure-Induced Depression through Reduced sigma 1-Receptor Expression
Yasuharu Shinoda; Hideaki Tagashira; Md. Shenuarin Bhuiyan; Hideyuki Hasegawa; Hiroshi Kanai; Chen Zhang; Feng Han; Kohji Fukunaga
PLOS ONE, 2016年10月, 査読有り
筆頭著者

Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain
Rie Kusano; Kousuke Fujita; Yasuharu Shinoda; Yuko Nagaura; Hiroshi Kiyonari; Takaya Abe; Toshio Watanabe; Yasuhisa Matsui; Masahiro Fukaya; Hiroyuki Sakagami; Tatsuya Sato; Jun-ichi Funahashi; Motoko Ohnishi; Shinri Tamura; Takayasu Kobayashi
FEBS LETTERS, 2016年10月, 査読有り

Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction
Yasuharu Shinoda; Hideaki Tagashira; Md. Shenuarin Bhuiyan; Hideyuki Hasegawa; Hiroshi Kanai; Kohji Fukunaga
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2016年07月, 査読有り
筆頭著者

Alzheimer disease therapeutics candidate, SAK3 improves the cognitive functions through inhibition of amyloid beta accumulation in APP23 mice.
Hisanao Izumi; Yasushi Yabuki; Yasuharu Shinoda; Kohji Fukunaga
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2016年06月, 査読有り

Memory Improvement by Yokukansankachimpihange and Atractylenolide III in the Olfactory Bulbectomized Mice
Hisanao Izumi; Yuzuru Sasaki; Yasushi Yabuki; Yasuharu Shinoda; Nina Fujita; Satoshi Yomoda; Kohji Fukunaga
Advances in Alzheimer's Disease, 2016年, 査読有り

Dehydroepiandrosterone administration improves memory deficits following transient brain ischemia through sigma-1 receptor stimulation
Yasushi Yabuki; Yasuharu Shinoda; Hisanao Izumi; Tatuya Ikuno; Norifumi Shioda; Kohji Fukunaga
BRAIN RESEARCH, 2015年10月, 査読有り

Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis
Hideaki Tagashira; Yasuharu Shinoda; Norifumi Shioda; Kohji Fukunaga
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2014年12月, 査読有り

Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites
Yasuharu Shinoda; Kohsuke Fujita; Satoko Saito; Hiroyuki Matsui; Yusuke Kanto; Yuko Nagaura; Kohji Fukunaga; Shinri Tamura; Takayasu Kobayashi
FEBS LETTERS, 2012年09月, 査読有り
筆頭著者

Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels
Kohji Fukunaga; Hisanao Izumi; Yasushi Yabuki; Yasuharu Shinoda; Norifumi Shioda; Feng Han
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2019年02月, 査読有り

Sigma-1受容体の生理機能と筋萎縮性側索硬化症との関連
福永 浩司; 篠田 康晴
生化学, 2017年, 査読有り
ラスト(シニア)オーサー

The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis
Kohji Fukunaga; Yasuharu Shinoda; Hideaki Tagashira
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015年01月, 査読有り

北米神経科学学会

日本循環薬理学会

日本ケミカルバイオロジー学会

日本神経化学会

日本生化学会

日本薬理学会

日本薬学会

遠位尿細管特異的遺伝子改変マウスを駆使した急性腎障害機序の解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
2022年04月01日 - 2025年03月31日

シグマ１受容体変異を伴う筋萎縮性側索硬化症の病態解明と創薬
日本学術振興会, 科学研究費助成事業, 若手研究
東北大学
2020年04月01日 - 2023年03月31日

自閉症スペクトラム症のミトコンドリア障害と治療薬開発
日本学術振興会, 科学研究費助成事業, 基盤研究(B)
東北大学
2019年04月01日 - 2022年03月31日