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Last Updated :2024/04/12

廣松　賢治

医学科
教授

プロフィール1989-1995　γδ型T細胞の細胞内寄生菌に対する防御免疫 1996-2006　CDI分子による結核菌由来糖脂質抗原提示 2002-2006 病原微生物の免疫系からのエスケープ機構 　2002-2006 蠕虫由来糖脂質抗原の解析

研究者情報

■ 学位
  • 医学博士, 九州大学
■ 研究キーワード
  • ワクチン
  • 糖脂質
  • CD1
  • エスケープ機構
  • 細胞内寄生性細菌
  • 生体防御

経歴

■ 学歴
  • 1993年
    九州大学, 医学系研究科, 内科学
  • 1986年
    九州大学, 医学部, 医学科

研究活動情報

■ 論文
  • MiR-4535 and MiR-1915-5p in Amniotic Fluid as Predictive Biomarkers for Chorioamnionitis
    漆山 大知; 深川 怜史; 平川 豊文; 吉川 賢一; 井槌 大介; 宮田 康平; 倉員 正光; 四元 房典; 廣松 賢治; 太田 栄治; 廣瀬 伸一; 安永 晋一郎; 宮本 新吾
    Future Science OA, 2021年, 査読有り
  • Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells
    Emi Sato; Shinichi Imafuku; Kazunari Ishii; Ryota Itoh; Bin Chou; Toshinori Soejima; Juichiro Nakayama; Kenji Hiromatsu
    JOURNAL OF DERMATOLOGICAL SCIENCE, 2013年06月, 査読有り
  • Antiangiogenic Tumor Therapy by DNA Vaccine Inducing Aquaporin-1-Specific CTL Based on Ubiquitin-Proteasome System in Mice
    Bin Chou; Kenji Hiromatsu; Shinji Okano; Kazunari Ishii; Xuefeng Duan; Tohru Sakai; Shigeo Murata; Keiji Tanaka; Kunisuke Himeno
    JOURNAL OF IMMUNOLOGY, 2012年08月, 査読有り
  • Topical vitamin D₃ analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions.
    Sato-Deguchi E; Imafuku S; Chou B; Ishii K; Hiromatsu K; Nakayama J
    Br J Dermatol., 2012年07月, 査読有り
  • ユビキチン化DNAワクチンによるＣＤ８Ｔ細胞の誘導
    石井一成; 廣松賢治
    臨床免疫…アレルギー科, 2012年
  • Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs
    Yuki Hattori; Isamu Matsunaga; Takaya Komori; Tetsuo Urakawa; Takashi Nakamura; Nagatoshi Fujiwara; Kenji Hiromatsu; Hideyoshi Harashima; Masahiko Sugita
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011年06月, 査読有り
  • A Microbial Glycolipid Functions as a New Class of Target Antigen for Delayed-type Hypersensitivity
    Takaya Komori; Takashi Nakamura; Isamu Matsunaga; Daisuke Morita; Yuki Hattori; Hirotaka Kuwata; Nagatoshi Fujiwara; Kenji Hiromatsu; Hideyoshi Harashima; Masahiko Sugita
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011年05月, 査読有り
  • Up-Regulation of Intestinal Toll-Like Receptors and Cytokines Expressions Change After TPN Administration and a Lack of Enteral Feeding
    Takuto Ikeda; Kenji Hiromatsu; Masayuki Hotokezaka; Kazuo Chijiiwa
    JOURNAL OF SURGICAL RESEARCH, 2010年05月, 査読有り
  • Genetic immunization based on the ubiquitin-fusion degradation pathway against Trypanosoma cruzi
    Bin Chou; Kenji Hiromatsu; Hajime Hisaeda; Xuefeng Duan; Takashi Imai; Shigeo Murata; Keiji Tanaka; Kunisuke Himeno
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010年02月, 査読有り
  • クラミジア感染マウスモデルにおけるCD1分子を介した粘膜免疫システム
    廣松賢治
    化学療法の領域, 2009年07月
  • Ivermectin の皮下投与が奏効した重症播種性糞線虫症の１剖検例
    Takashima N; Yazawa S; Ishihara A; Sugimoto S; Shiomi K; Hiromatsu K; Nakazato M
    rinsho shinkeigaku, 2008年01月, 査読有り
  • Toxocariasis presenting with multiple effusions in the pericardial space, thoracic cavity, and Morrison's pouch
    Yasunori Matsuki; Tatsuya Fujii; Fukumi Nakamura-Uchiyama; Kenji Hiromatsu; Yukifumi Nawa; Takuya Hayashi; Shingo Ohtomi
    INTERNAL MEDICINE, 2007年, 査読有り
  • ＭＲＩで大腿の皮下硬結内に索状影を認めたマンソン孤虫症の１例
    2007年, 査読有り
  • BCG vaccine elicits both T-cell mediated and humoral immune responses directed against mycobacterial lipid components
    Yoshiyuki Watanabe; Eiji Watari; Isamu Matsunaga; Kenji Hiromatsu; Christopher C. Dascher; Tetsuo Kawashima; Yoshihiko Norose; Kazuo Shimizu; Hidemi Takahashi; Ikuya Yano; Masahiko Sugita
    VACCINE, 2006年07月, 査読有り
  • A case of Ascaris suum visceral larva migrans diagnosed by using A. suum larval excretory-secretory (ES) antigen
    F Nakamura-Uchiyama; Y Tokunaga; A Suzuki; N Akao; K Hiromatsu; S Hitomi; Y Nawa
    SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2006年03月
  • Strongyloides infection with chronic eosinophilic pneumonia
    Nakamura K; Ameku K; Shiomi T; Matsuura Y; Hiromatsu K
    Nippon Naika Gakkai Zasshi, 2006年, 査読有り
  • A case of toxocariasis with eosinophilic pleural effusion
    Seki M; Hiromatsu K; Kosai K; Fukuda Y; Kakugawa T; Nakamura F; Izumikawa K; Yanagihara K; Higashiyama Y; Miyazaki Y; Hirakata Y; Mukae H; Tashiro T; Kohno S
    Kansenshogaku Zasshi, 2006年, 査読有り
  • A case of the myelitis due to Toxocara canis infection complicated with cervical spondylosis
    Mitsuhashi Y; Naitou K; Yamauchi S; Naruse H; Matsuoka Y; Nakamura-Uchiyama F; Hiromatsu K
    No Shinkei Geka, 2006年, 査読有り
  • Chronic intestinal nematode infection induces Stat6-independent interleukin-5 production and causes eosinophilic inflammatory responses in mice
    Y Sakamoto; K Hiromatsu; K Ishiwata; K Inagaki-Ohara; T Ikeda; F Nakamura-Uchiyama; Y Nawa
    IMMUNOLOGY, 2004年08月, 査読有り
  • Mucosal T cells bearing TCRγδ play a protective role in intestinal inflammation
    Kyoko Inagaki-Ohara; Takatoshi Chinen; Goro Matsuzaki; Atsuo Sasaki; Yukiko Sakamoto; Kenji Hiromatsu; Fukumi Nakamura-Uchiyama; Yukifumi Nawa; Akihiko Yoshimura
    Journal of Immunology, 2004年07月15日, 査読有り
  • Paragonimiasis cases recently found among immigrants in Japan
    A Obara; F Nakamura-Uchiyama; K Hiromatsu; Y Nawa
    INTERNAL MEDICINE, 2004年05月, 査読有り
  • Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation.
    Inagaki-Ohara K; Chinen T; Matsuzaki G; Sasaki A; Sakamoto Y; Hiromatsu K; Nakamura-Uchiyama F; Nawa Y; Yoshimura A
    J Immunol, 2004年, 査読有り
  • The current status of parasitic diseases in Japan.
    Nakamura-Uchiyama, F; K. Hiromatsu; K. Ishiwata; Y. Sakamoto; Y. Nawa
    Intern Med, 2003年
  • Upregulation of group 1 CD 1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis: An immunohistochemical study
    B Cipriani; LF Chen; K Hiromatsu; H Knowles; CS Raine; L Battistini; SA Porcelli; CF Brosnan
    BRAIN PATHOLOGY, 2003年01月
  • Evaluation of the antigenic similarities of adult-worm extracts from three Gnathostoma species, using sera from Maxican and Japanese patients with Gnathostoma infections.
    Ishiwata, K; S. P. Camacho; K. Ogata; F. Nakamura-Uchiyama; K. Hiromatsu; Y. Nawa
    Ann Trop Med parasitol, 2003年
  • Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis.
    Dascher, C. C; K. Hiromatsu; X. Xiong; C. Morehouse; G. Watts; G. Liu; D. N. McMurray; K. P. LeClair; S. A. Porcelli; M. B. Brenner
    Int Immunol, 2003年
  • Effects of anti-CD 154 treatment on B cells in murine systemic lupus erythemotosus.
    Wang, X; W. Huang; L. E. Schiffer; M. Mihara; A. Akkerman; K. Hiromatsu; A. Davidson
    Arthritis Rheum, 2003年, 査読有り
  • Characterization of guinea-pig group 1 CD1 proteins
    K Hiromatsu; CC Dascher; M Sugita; C Gingrich-Baker; SM Behar; KP LeClair; MB Brenner; SA Porcelli
    IMMUNOLOGY, 2002年06月, 査読有り
  • Conservation of CD1 intracellular trafficking patterns between mammalian species.
    Dascher, C. C; K. Hiromatsu; X. Xiong; M. Sugita; J. E. Buhlmann; I. L. Dodge; S. Y. Lee; C. Roura-Mir; G. F. Watts; C. J. Roy; S. M. Behar; D. L. Clemens; S. A. Porcelli; M. B. Brenner
    J Immunol, 2002年, 査読有り
  • Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens.
    Hiromatsu, K; C. C. Dascher; K. P. LeClair; M. Sugita; S. T. Furlong; M. B. Brenner; S. A. Porcelli
    J Immunol, 2002年
  • Selective diapedesis of Th1 cells induced by endothelial cell RANTES.
    Kawai, T; M. Saki; K. Hiromatsu; J. W. Eastcott; G. F. Watts; M. Sugai; D. J. Smith; S. A. Porcelli; M. A. Taubman
    J Immunol, 1999年, 査読有り
  • Conservation of a CD1 multigene family in the guinea pig.
    Dascher, C. C; K. Hiromatsu; J. W. Naylor; P. P. Brauer; K. A. Brown; J. R. Storey; S. M. Behar; E. S. Kawasaki; S. A. Porcelli; M. B. Brenner; K. P. LeClair
    J Immunol, 1999年, 査読有り
  • The role of gamma delta T cells in induction of bacterial antigen-specific protective CD8(+) cytotoxic T cells in immune response against the intracellular bacteria Listeria monocytogenes
    A Nomura; G Matsuzaki; H Takada; K Hiromatsu; S Nabeshima; T Nakamura; K Kishihara; K Nomoto
    IMMUNOLOGY, 1998年10月, 査読有り
  • A sustained increase of cytosolic Ca(2+) in gamma delta T cells triggered by co-stimulation via TCR/CD3 and LFA-1
    N Kobayashi; K Hiromatsu; G Matsuzaki; M Harada; Y Matsumoto; K Nomoto; Y Yoshikai
    CELL CALCIUM, 1997年12月
  • Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome
    S Toki; K Hiromatsu; Y Aoki; M Makino; Y Yoshikai
    CYTOKINE, 1997年10月, 査読有り
  • Clonal expansion of superantigen-reactive-T cells is resistant to FK506 in mice with AIDS.
    Yoshikai, Y; H. Kidokoro; K. Kimura; Y. Aoki; M. Makino; K. Hiromatsu
    J Virol, 1997年
  • Accelerated progression of a murine retrovirus-induced immunodeficiency syndrome in Fas mutant C57BL/6 lpr/lpr mice.
    Hiromatsu, K; J. Usami; Y. Aoki; M. Makino; Y. Yoshikai
    Microbiol Immunol, 1997年, 査読有り
  • CD4 expression is important but not essential for infection with exogenous mouse mammary tumor virus
    Y Ando; W Wajjwalku; K Kishihara; T Arai; N Niimi; K Hiromatsu; T Morishima; Y Yoshikai
    IMMUNOBIOLOGY, 1996年08月
  • ThO-like CD4+ T cells protect mice with murine retrovirus-induced immunodeficiency syndrome (MAIDS) against co-infection with Listeria monocytogenes.
    Hiromatsu, K; H. Nishimura; K. Kimura; Y. Aoki; J. Usami; N. Kobayashi; M. Makino; Y. Yoshikai
    Immunology, 1996年
  • Evidence for the early recruitment of T-cell receptor gamma delta+ T cells during rat listeriosis.
    Kimura, Y; S. Tomida; Y. Matsumoto; K. Hiromatsu; Y. Yoshikai
    Immunobiology, 1996年
  • IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection.
    Nishimura, H; K. Hiromatsu; N. Kobayashi; K. H. Grabstein; R. Paxton; K. Sugamura; J. A. Bluestone; Y. Yoshikai
    J Immunol, 1996年
  • Apoptosis by CD95(Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome.
    Usami, J; K. Hiromatsu; Y. Aoki; N. Kobayashi; M. Makino; H. Yagita; Y. Matsumoto; K. Maeda; Y. Yoshikai
    J Virol, 1996年, 査読有り
  • PROTECTIVE EFFECT OF GRANULOCYTE-COLONY-STIMULATING FACTOR AGAINST T-CELL-MEDITATED LETHAL SHOCK TRIGGERED BY SUPERANTIGENS
    Y AOKI; K HIROMATSU; N KOBAYASHI; T HOTTA; H SAITO; H IGARASHI; Y NIHO; Y YOSHIKAI
    BLOOD, 1995年08月
  • THE INDUCTION OF SKIN XENOGRAFT TOLERANCE IN RAT-TO-MOUSE COMBINATION COULD BE AFFECTED BY DFR MEDIATING CELLS AND ANTIBODIES AGAINST RAT BONE-MARROW CELLS AS WELL AS NK CELLS IN THE CYCLO-PHOSPHAMIDE-INDUCED TOLERANCE SYSTEM
    Y NISHIMURA; M ETO; T MAEDA; K HIROMATSU; K NOMOTO; YY KONG; K NOMOTO
    IMMUNOBIOLOGY, 1995年08月, 査読有り
  • INFECTION OF MYCOBACTERIUM-BOVIS BACILLUS-CALMETTE-GUERIN IN ANTIBODY-MEDIATED GAMMA-DELTA T-CELL-DEPLETED MICE
    S NABESHIMA; K HIROMATSU; G MATSUZAKI; A MUKASA; H TAKADA; S YOSHIDA; K NOMOTO
    IMMUNOLOGY, 1995年02月, 査読有り
  • Bacterial infection of the testis leading to autoaggressive immunity triggers apparently opposed responses of alpha beta and gamma delta T cells.
    Mukasa, A; K. Hiromatsu; G. Matsuzaki; R. O'Brien; W. Born; K. Nomoto
    J Immunol, 1995年, 査読有り
  • Concomitant infection with exogenous mouse mammary tumor virus encoding I-E-dependent superantigen in I-E-negative mouse strain.
    Ando, Y; W. Wajjwalku; N. Niimi; K. Hiromatsu; T. Morishima; Y. Yoshikai
    J Immunol, 1995年
  • Lethal shock is inducible by lipopolysaccharide but not by superantigen in mice with retrovirus-induced immunodeficiency syndrome.
    Aoki, Y; K. Hiromatsu; T. Arai; J. Usami; M. Makino; H. Ishida; Y. Yoshikai
    J Immunol , 1995年
  • Mice deficient in gamma delta T cells are resistant to lethal infection with Salmonella choleraesuis.
    Emoto, M; H. Nishimura; T. Sakai; K. Hiromatsu; H. Gomi; S. Itohara; Y. Yoshikai
    Infect Immun, 1995年
  • Effects on in vivo administration of anti-IL-10 monoclonal antibody on the host defence mechanism against murine Salmonella infection.
    Arai, T; K. Hiromatsu; H. Nishimura; Y. Kimura; N. Kobayashi; H. Ishida; Y. Nimura; Y. Yoshikai
    Immunology, 1995年
  • Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses.
    Hasegawa, T; M. Okuda; M. Makino; K. Hiromatsu; K. Nomoto; Y. Yoshikai
    Int J Immunopharmacol, 1995年
  • IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury.
    Arai, T; K. Hiromatsu; N. Kobayashi; M. Takano; H. Ishida; Y. Nimura; Y. Yoshikai
    J Immunol, 1995年
  • Endogenous interleukin 10 prevents apoptosis in macrophages during Salmonella infection.
    Arai, T; K. Hiromatsu; H. Nishimura; Y. Kimura; N. Kobayashi; H. Ishida; Y. Nimura; Y. Yoshikai
    Biochem Biophys Res Commun, 1995年
  • Lethal shock is inducible by lipopolysaccharide but not by superantigen in mice with retrovirus-induced immunodeficiency syndrome.
    Aoki, Y; K. Hiromatsu; T. Arai; J. Usami; M. Makino; H. Ishida; Y. Yoshikai
    J Immunol, 1995年
  • Development of TCR-gamma delta CD4-CD8+alpha but not TCR-alpha beta CD4-CD8+ alpha alpha i-IEL is resistant to cyclosporin A.
    Lin, T; G. Matsuzaki; Umesue; K. Omoto; H. Yoshida; M. Harada; C. Singaram; K. Hiromatsu; K. Nomoto
    J Immunol, 1995年, 査読有り
  • Early appearance of T cell receptor alpha beta + CD4- CD8- T cells with a skewed variable region repertoire after infection with Listeria monocytogenes.
    Matsuzaki, G; X. Y. Li; T. Kadena; F. Song; K. Hiromatsu; H. Yoshida; K. Nomoto
    Eur J Immunol, 1995年, 査読有り
  • Regulatory role of gamma delta T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response.
    Suzuki, T; K. Hiromatsu; Y. Ando; T. Okamoto; Y. Tomoda; Y. Yoshikai
    J Immunol, 1995年, 査読有り
  • The role of gamma delta T cells in priming macrophages to produce tumor necrosis factor-alpha.
    Nishimura, H; M. Emoto; K. Hiromatsu; S. Yamamoto; K. Matsuura; H. Gomi; T. Ikeda; S. Itohara; Y. Yoshikai
    Eur J Immunol, 1995年, 査読有り
  • INHIBITION OF SKIN XENOGRAFT - REJECTION BY DEPLETING T-CELL RECEPTOR ALPHA-BETA-BEARING CELLS WITHOUT T-CELL RECEPTOR GAMMA-DELTA-BEARING CELLS OR NATURAL-KILLER-CELLS BY MONOCLONAL-ANTIBODY
    Y NISHIMURA; M ETO; T MAEDA; K HIROMATSU; N KOBAYASHI; K NOMOTO; YY KONG; K NOMOTO
    IMMUNOLOGY, 1994年10月
  • INHIBITION OF ALLOGRAFT-REJECTION BY ANTI-T-CELL RECEPTOR-ALPHA-BETA MONOCLONAL-ANTIBODIES PRESERVING RESISTANCE TO BACTERIAL-INFECTION
    M ETO; Y YOSHIKAI; Y NISHIMURA; K HIROMATSU; T MAEDA; K NOMOTO; YY KONG; RT KUBO; J KUMAZAWA; K NOMOTO
    IMMUNOLOGY, 1994年02月
  • Analysis of the role of natural killer cells in Listeria monocytogenes infection: relation between natural killer cells and T-cell receptor gamma delta T cells in the host defence mechanism at the early stage of infection.
    Takeda, H; G. Matsuzaki; K. Hiromatsu; K. Nomoto
    Immunology, 1994年
  • Co-stimulation with LFA-1 triggers apoptosis in gamma delta T cells on T cell receptor engagement.
    Matsumoto, Y; K. Hiromatsu; T. Sakai; Y. Kobayashi; Y. Kimura; J. Usami; T. Shinzato; K. Maeda; Y. Yoshikai
    Eur J Immunol, 1994年
  • [The involvement of gamma delta T cells in neurological disorders].
    Hiromatsu, K; Y. Kobayashi; Y. Yoshikai
    Nippon Rinsho, 1994年
  • Hypernatremic myopathy.
    Hiromatsu, K; T. Kobayashi; N. Fujii; Y. Itoyama; I. Goto; J. Murakami
    J Neurol Sci, 1994年
  • Increased Fas antigen expression in murine retrovirus-induced immunodeficiency syndrome, MAIDS.
    Hiromatsu, K; Y. Aoki; M. Makino; Y. Matsumoto; T. Mizuochi; Y. Gotoh; K. Nomoto; J. Ogasawara; S. Nagata; Y. Yoshikai
    Eur J Immunol, 1994年
  • CHARACTERIZATION OF T-CELL RECEPTOR-GAMMA-DELTA T-CELLS APPEARING AT THE EARLY PHASE OF MURINE LISTERIA-MONOCYTOGENES INFECTION
    G MATSUZAKI; K HIROMATSU; Y YOSHIKAI; K MURAMORI; K NOMOTO
    IMMUNOLOGY, 1993年01月
  • Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis.
    Dascher, C. C; K. Hiromatsu; X. Xiong; C. Morehouse; G. Watts; G. Liu; D. N. McMurray; K. P. LeClair; S. A. Porcelli; M. B. Brenner
    Int Immunol, 1993年, 査読有り
  • Peritoneal gamma delta T cells induced by Escherichia coli infection in mice. Correlation between Thy-1 phenotype and host minor lymphocyte-stimulating phenotype.
    Takeda, H; K. Hiromatsu; G. matsuzaki; K. Muramori; K. Nomoto
    J Immunol, 1993年, 査読有り
  • A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice.
    Hiromatsu, K; Y. Yoshikai; G. Matsuzaki; S. Ohga; K. Muramori; K. Matsumoto; J. A Bluestone; K. Nomoto
    J Exp Med, 1992年, 査読有り
  • Sequential appearance of gamma/delta-and alpha/beta-bearing T cells in the peritoneal cavity during an i. p. infection with Listeria monocytogenes.
    Ohga, S; Y. Yoshikai; Y. Takeda; K. Hiromatsu; K. Nomoto
    Eur J Immunol, 1990年, 査読有り
■ 講演・口頭発表等
  • 2020年6-8月の福岡大学の病院職員におけるSARS-CoV-2抗体保有状況の報告
    坂本 篤彦; 伊藤 竜太; 吉村 芳修; 崎原 永志; 加藤 禎史; 日吉 哲也; 増井 信太; 石井 一成; 廣松 賢治; 鍋島 茂樹
    第21回日本病院総合診療医学会総会, 2020年09月26日
  • Different polarized neutrophils induction after lung infection with Chlamydia pneumoniae or Chlamydia trachomatis mouse pneumonitis
    Chou Bin; Ishii Kazaunari; Sato Emi; Hiromatsu Kenji
    日本免疫学会総会, 2012年12月05日
  • The role of murine cathelididin-related antimicrobial peptide in Mycobacterium marinum infection
    Sato Emi; Ishii Kazaunari; Chou Bin; Hiromatsu Kenji
    日本免疫学会総会, 2012年12月05日
  • Mitochondrial ROS/NLRP3 inflammasome mediated caspase-1 activation promotes intracellular growth of Chlamydia pneumoniae in adipocytes
    Murakami Issaku; Rryota Itoh; Chou Bin; Ishii Kazaunari; Sato Emi; Hiromatsu Kenji
    日本免疫学会総会, 2012年12月05日
  • C. pneumonia utilize host innate immune Nlrp3 inflammasome activation for intracellular growth
    Kenji Hiromatsu; Issaku Murakami; Emi Satoh; Ryota Itoh
    第８５回日本細菌学会総会 WS12感染防御応答の多次元シグナルネットワーク, 2012年03月29日
  • クラミジア経腟感染に対する免疫応答と子宮付属器炎発症の解析
    副島利紀; 石井一成; 廣松賢治
    第８５回日本細菌学会総会, 2012年03月27日
  • NLRP3 inflammasome activation is required for intracellular growth of Chlamydia pneumoniae in murine bone marrow macrophages.
    Ryota ITOH; Kenji HIROMATSU
    International Congress of Bacteriology and Applied Microbiology (IUMS 2011), 2011年09月07日
  • C. pneumoniae can infect in Adipocytes and its proliferation is regulated by Nlrp3 inflammasome mediated Caspase-1 activation.
    Issaku MURAKAMI; Ryota ITOH; Chou BIN; Kenji HIROMATSU
    International Congress of Bacteriology and Applied Microbiology (IUMS 2011), 2011年09月07日
  • Chlamydia pneumoniae induces macrophages alternative activation as a survival mechanism.
    Emi DEGUCHI; Ryota ITOH; Kenji HIROMATSU
    International Congress of Bacteriology and Applied Microbiology (IUMS 2011), 2011年09月07日
  • Induction of CD8+ T cell protective immunity against Chlamydia trachomatis mouse pneumonitis strain by ubiquitin-fusion DNA vaccine.
    Kazunari Ishii; Bin Chou; Ryota Itoh; Toshinori Soejima; Kenji Hiromatsu
    International Congress of Bacteriology and Applied Microbiology (IUMS 2011), 2011年09月07日
  • Influenza A virus suppression of autophagosome maturation and its reversal by maoto, a traditional herbal medicine.
    Shigeki Nabeshima; Kei Yamauchi; Shinta Masui; Kazunari Ishi; Toshinori Soejima; Kenji Hiromatsu
    International Congress of Bacteriology and Applied Microbiology (IUMS 2011), 2011年09月07日
  • Inflammasome dependent caspase-1 activation induced in murine bone marrow derived macrophages by C.pneumoniae but no C. trachomatis or C.muridarum
    R. Itoh; C. Bin; K. Hiromatsu
    14th International congress of Immunology, 2010年08月25日
  • Successful inhibition and treatment of melanoma by genetic immunization with plasmids encoding ubiquitin conjugated aquaporin-1
    B.Chou; K.Hiromatsu; S.Okano; K.Himeno
    14th International congress of Immunology, 2010年08月25日
  • Chlamydia pneumonia 感染に対するマクロファージの特異的な免疫応答
    伊藤竜太; 仇斌; 廣松賢治
    第83回日本細菌学会総会, 2010年03月28日
  • Neutrophils induce Th1 type immunity in lung infection with Chlamydia muridarum
    仇斌; 石井一成; 伊藤竜太; 副島利紀; 廣松賢治
    第83回日本細菌学会総会, 2010年03月28日
  • Differential regulation of inflammatory cyotokine secretion by M1 and M2-polarized murine macrophages upon Chlamydia pneumonia infection
    Itoh Ryota; Chou Bin; Kenji Hiromatsu
    第39回日本免疫学会総会, 2009年12月04日
  • Induction of CD8 T cells protective immunity against Chlamydia trachomatis mouse pneumonitis strain by ubiquitin-fusion DNA vaccine
    Ishii Kazunari; Chou Bin; Itho Ryota; Soejima Toshinori; Himeno Kunisuke; Hiromatsu Kenji
    第39回日本免疫学会総会, 2009年12月04日
  • Protective role of iNKT cells on the resolution of C.trachomatis genital tract infection
    Ohnishi Yoshiki; Itho Ryota; Soejima Toshinori; Ishii Kazunari; Kenji Hiromatsu
    第39回日本免疫学会総会, 2009年12月04日
  • Development of a new DNA immunization therapy targeting tumor angiogenesis
    仇斌; 廣松賢治; 岡野慎士; 石井一成; 伊藤竜太; 姫野国祐
    第39回日本免疫学会総会, 2009年12月03日
  • Protective role of iNKT cells on the resolution of C.trachomatis genital tract infection
    Kenji Hiromatsu; Yoshiki Ohnishi; Ryota Itoh; Kazunari Ishii
    The 5th International symposium on CD1/NKT cells., 2009年03月28日
  • Role of NKT cells during Chlamydia trachomatis mouse pneumonitis lung infectio in mice
    濱田利徳; 石井一成; 伊藤竜太; 大西克樹; 仇斌; 副島利紀; 廣松賢治
    第82回日本細菌学会総会, 2009年03月13日
  • Innate and adaptive immune responses during genital tract infection with C.trachomatis
    大西克樹; 伊藤竜太; 石井一成; 副島利紀; 仇斌; 廣松賢治
    第82回日本細菌学会総会, 2009年03月13日
  • Role of NKT cells in the genital tract of mice infected by Chlamydia trachomatis
    Ohnishi Yoshiki; Ishii Kazunari; chou Bin; Hamada Toshinori; Soejima Toshinori; Hiromatsu Kenji
    第38回日本免疫学会総会, 2008年12月02日
  • Role of NKT dells during Chlamydia trachomatis mouse pneumonia lung infection in mice
    Hamada Toshinori; Ishii Kazunari; Ohnishi Yoshiki; Chou Bin; Itoh Ryota; Soejima Toshinaori; Hiromatsu Kenji
    第38回日本免疫学会総会, 2008年12月02日
■ 所属学協会
  • 日本免疫学会
  • 日本細菌学会
  • 日本寄生虫学会
■ 産業財産権
  • 出願2009-95547, ユビキチン融合遺伝子およびそれを用いたDNAワクチン