Association of T cell infiltration and morphological change of thymus gland with the aggravation of pulmonary emphysema in testosterone deficiency.
Kentaro Aono; Junichi Matsumoto; Taichi Matsumoto; Mitsuhisa Koga; Keisuke Migita; Koji Tominaga; Shinsuke Nakagawa; Atsushi Yamauchi
Biochemistry and biophysics reports, Jul. 2023

Bortezomib Increased Vascular Permeability by Decreasing Cell-Cell Junction Molecules in Human Pulmonary Microvascular Endothelial Cells.
Taichi Matsumoto; Junichi Matsumoto; Yuka Matsushita; Moeno Arimura; Kentaro Aono; Mikiko Aoki; Kazuki Terada; Masayoshi Mori; Yutaka Haramaki; Takuya Imatoh; Atsushi Yamauchi; Keisuke Migita
International journal of molecular sciences, 29 Jun. 2023

Senescence in brain pericytes attenuates blood-brain barrier function in vitro: A comparison of serially passaged and isolated pericytes from aged rat brains.
Takuro Iwao; Fuyuko Takata; Junichi Matsumoto; Yuki Goto; Hisataka Aridome; Miho Yasunaga; Miki Yokoya; Yasufumi Kataoka; Shinya Dohgu
Biochemical and biophysical research communications, 19 Feb. 2023

Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice.
Takuro Iwao; Fuyuko Takata; Junichi Matsumoto; Hisataka Aridome; Miho Yasunaga; Miki Yokoya; Yasufumi Kataoka; Shinya Dohgu
PloS one, 2023

Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
Taira Matsuo; Rie Komori; Minami Nakatani; Shiori Ochi; Aya Yokota-Nakatsuma; Junichi Matsumoto; Fuyuko Takata; Shinya Dohgu; Yasuhiro Ishihara; Kouichi Itoh
International journal of molecular sciences, 12 Jul. 2022

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction
Takata F; Nakagawa S; Matsumoto J; Dohgu S
Front Cell Neurosci., 13 Sep. 2021, Refereed

Testosterone deficiency promotes the development of pulmonary emphysema in orchiectomized mice exposed to elastase.
Aono K; Matsumoto J; Nakagawa S; Matsumoto T; Koga M; Migita K; Tominaga K; Sakai Y; Yamauchi A
Biochem Biophys Res Commun., 18 Jun. 2021, Refereed

Serum amyloid A-induced blood-brain barrier dysfunction associated with decreased claudin-5 expression in rat brain endothelial cells and its inhibition by high-density lipoprotein in vitro
Matsumoto J; Dohgu S; Takata F; Iwao T; Kimura I; Tomohiro M; Aono K; Kataoka Y; Yamauchi A
Neurosci Lett., 22 Sep. 2020, Refereed
Lead

Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis.
Sheng L; Stewart T; Yang D; Thorland E; Soltys D; Aro P; Khrisat T; Xie Z; Li N; Liu Z; Tian C; Bercow M; Matsumoto J; Zabetian CP; Peskind E; Quinn JF; Shi M; Zhang J
Acta Neuropathol Commun., 08 Jul. 2020, Refereed

Oncostatin-M-Reactive Pericytes Aggravate Blood-Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro.
Takata F; Dohgu S; Sakaguchi S; Sakai K; Yamanaka G; Iwao T; Matsumoto J; Kimura I; Sezaki Y; Tanaka Y; Yamauchi A; Kataoka Y
Neuroscience, Nov. 2019, Refereed

Oligodendrocytes upregulate blood-brain barrier function through mechanisms other than the PDGF-BB/PDGFRα pathway in the barrier-tightening effect of oligodendrocyte progenitor cells
Kimura I; Dohgu S; Takata F; Matsumoto J; Watanabe T; Iwao T; Yamauchi A; Kataoka Y
Neurosci Lett., 13 Oct. 2019, Refereed

Monomeric α-synuclein induces blood-brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro
Dohgu S; Takata F; Matsumoto J; Kimura I; Yamauchi A; Kataoka Y
Microvasc Res, 15 May 2019, Refereed

Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells
Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Yohei Kawahara; Megumi Nishihira; Shohei Sakada; Takuya Saisho; Atsushi Yamauchi; Yasufumi Kataoka
Neurosci Lett., 16 Feb. 2019, Refereed

Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro.
Takata F; Dohgu S; Matsumoto J; Machida T; Sakaguchi S; Kimura I; Yamauchi A; Kataoka Y
J Cell Biochem., Nov. 2018

TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways
Junichi Matsumoto; Shinya Dohgu; Fuyuko Takata; Takashi Machida; Funda F. Bölükbaşi Hatip; Izzettin Hatip-Al-Khatib; Atsushi Yamauchi; Yasufumi Kataoka
Brain Research, 01 Aug. 2018

Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson’s disease.
Nakashima A; Yamauchi A; Matsumoto J; Dohgu S; Takata F; Koga M; Fukae J; Tsuboi Y; Kataoka Y
Behav Pharmacol, 25 May 2018

Transmission of alpha-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease?
Junichi Matsumoto; Tessandra Stewart; Lifu Sheng; Na Li; Kristin Bullock; Ning Song; Min Shi; William A. Banks; Jing Zhang
ACTA NEUROPATHOLOGICA COMMUNICATIONS, Sep. 2017, Refereed

Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model
Takashi Machida; Fuyuko Takata; Junichi Matsumoto; Tomoyuki Miyamura; Ryosuke Hirata; Ikuya Kimura; Yasufumi Kataoka; Shinya Dohgu; Atsushi Yamauchi
PLOS ONE, May 2017

ROLE OF THROMBIN-PAR1-PKC theta/delta AXIS IN BRAIN PERICYTES IN THROMBIN-INDUCED MMP-9 PRODUCTION AND BLOOD-BRAIN BARRIER DYSFUNCTION IN VITRO
Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Ikuya Kimura; Mariko Koga; Keiko Nakamoto; Atsushi Yamauchi; Yasufumi Kataoka
NEUROSCIENCE, May 2017, Refereed

The transport mechanism of extracellular vesicles at the blood-brain barrier.
Matsumoto J; Stewart T; Banks WA; Zhang J
Curr Pharm Des, 2017, Refereed

Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood-brain barrier in vitro
Takashi Machida; Fuyuko Takata; Junichi Matsumoto; Hisayo Takenoshita; Ikuya Kimura; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Jul. 2015

Nifedipine Prevents Sodium Caprate-Induced Barrier Dysfunction in Human Epidermal Keratinocyte Cultures
Yoshihiro Uchino; Junichi Matsumoto; Takuya Watanabe; Masato Hamabashiri; Takashi Tsuchiya; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2015, Refereed

Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons
Hiroyuki Takahashi; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2015

Tumor necrosis factor-α reduces beta-amyloid accumulation primarily by lowering cellular prion protein levels in a brain endothelial cell line.
Yasutaka Y; Watanabe T; Nakashima A; Matsumoto J; Futagami K; Yamauchi A; Kataoka Y
FEBS Lett, Dec. 2014, Refereed

Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation
Junichi Matsumoto; Fuyuko Takata; Takashi Machida; Hiroyuki Takahashi; Yuki Soejima; Miho Funakoshi; Koujiro Futagami; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Aug. 2014, Refereed

Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells
Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Takashi Machida; Shuji Kaneshima; Mai Matsuo; Shinya Sakaguchi; Yuki Takeshige; Atsushi Yamauchi; Yasufumi Kataoka
Biochemical and Biophysical Research Communications, 19 Apr. 2013, Refereed

In Vitro Blood-Brain Barrier Models Using Brain Capillary Endothelial Cells Isolated from Neonatal and Adult Rats Retain Age-Related Barrier Properties
Fuyuko Takata; Shinya Dohgu; Atsushi Yamauchi; Junichi Matsumoto; Takashi Machida; Kayoko Fujishita; Keisuke Shibata; Youichi Shinozaki; Kaoru Sato; Yasufumi Kataoka; Schuichi Koizumi
PLoS ONE, 31 Jan. 2013, Refereed

Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells
Junichi Matsumoto; Shinya Dohgu; Fuyuko Takata; Tsuyoshi Nishioku; Noriko Sumi; Takashi Machida; Hiroyuki Takahashi; Atsushi Yamauchi; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Aug. 2012, Refereed

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro.
Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Hiroyuki Takahashi; Takashi Machida; Tomoya Wakigawa; Eriko Harada; Haruki Miyaji; Mitsuhisa Koga; Tsuyoshi Nishioku; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF NEUROINFLAMMATION, Aug. 2011, Refereed

Partial hepatectomy aggravates cyclosporin A-induced neurotoxicity by lowering the function of the blood-brain barrier in mice
Atsushi Yamauchi; Shinya Dohgu; Fuyuko Takata; Takuya Watanabe; Tsuyoshi Nishioku; Junich Matsumoto; Yuka Ohkubo; Hideki Shuto; Yasufumi Kataoka
LIFE SCIENCES, Mar. 2011, Refereed

Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1
Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Masatoshi Oda; Eriko Harada; Takuya Watanabe; Tsuyoshi Nishioku; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
MICROVASCULAR RESEARCH, Jan. 2011, Refereed

Medication use as a risk factor for inpatient falls in an acute care hospital: a case-crossover study
Hideki Shuto; Osamu Imakyure; Junichi Matsumoto; Takashi Egawa; Ying Jiang; Masaaki Hirakawa; Yasufumi Kataoka; Takashi Yanagawa
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, May 2010

Tumor necrosis factor-α mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells
Tsuyoshi Nishioku; Junichi Matsumoto; Shinya Dohgu; Noriko Sumi; Kenji Miyao; Fuyuko Takata; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
Journal of Pharmacological Sciences, 2010, Refereed

Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia.
Sumi N; Nishioku T; Takata F; Matsumoto J; Watanabe T; Shuto H; Yamauchi A; Dohgu S; Kataoka Y
Cellular and molecular neurobiology., Mar. 2009

COPDモデルマウスにおけるリポキシンA4に対するエストロゲンの影響
冨永 宏治; 青野 健太郎; 松本 純一; 古賀 允久; 山内 淳史; 江川 孝; 片岡 泰文
日本薬学会年会要旨集, Mar. 2020

Nicotinic acetylcholine receptors modulate TNF-alpha-induced MMP-9 release from brain pericytes
Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

Adenosine stimulates brain pericytes to release matrix metalloproteinase-9 through A3 adenosine receptor
Makoto Shougakiuchi; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Yui Yamamoto; Haruka Aikawa; Satomi Nagata; Shinya Dohgu; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013

Brain pericyte-derived soluble factors induce the blood-brain barrier dysfunction under pathological conditions
Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Hiroyuki Takahashi; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013

Alpha7 nicotinic acetylcholine receptor mediates MMP-9 release from brain pericytes
Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Atsushi Noriyuki; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013

Brain pericytes contribute to the blood-brain barrier disruption induced by thrombin
Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hisayo Takenoshita; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013

Brain pericytes-specific TNF-alpha-induced MMP-9 release is mediated by ROS and delayed activation of ERK1/2 and Akt
Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Haruki Miyaji; Yui Sonogi; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-alpha, releasing matrix metalloproteinase-9 and migrating in vitro
Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Takashi Machida; Hiroyuki Takahashi; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

Brain pericytes prevent migration of the inflammatory cells across the blood-brain barrier
Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Takashi Machida; Natsuko Ichiki; Natsuko Seki; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

Brain pericytes among BBB cells possess the most sensitive machinery of TNF-a - MMP-9 pathway due to high expression levels of TNF-R2 and long-lasting activation of ERK1/2 and Akt
Haruki Miyaji; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Yui Sonogi; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

TNF-alpha-induced release of IL-6 from brain pericytes through JAK/STAT signaling pathway
Sayaka Tao; Junichi Matsumoto; Fuyuko Takata; Hiroyuki Takahashi; Manami Kawaguchi; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

Brain pericytes release matrix metalloproteinase-9 in response to brain endothelial cells-derived ectonucleotidase CD39/ENTPDase1 under hypoxia/aglycemia condition
Tatsuya Furuno; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Tomo Nanri; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

Brain pericytes prevents migration of the inflammatory cells across the blood-brain barrier
Natsuko Ichiki; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Natsuko Seki; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

Brain pericytes facilitate insulin-induced phosphorylation of Akt in the hypothalamic neuronal cells
Hiroyuki Takahashi; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

BBB hyperpermeability to sodium fluorescein in obese mice with impaired glucose tolerance induced by high-fat diet
Fuyuko Takata; Shinya Dohgu; Takashi Obara; Junichi Matsumoto; Tsuyoshi Nishioku; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

Calcineurin/NFAT signaling regulates MMP-9 expression in brain pericytes
Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Tatsuya Fruno; Shuji Kaneshima; Takuya Watanabe; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

Reactive oxygen species (ROS)-mediated regulation of MMP-9 expression in the brain pericytes
Kousuke Matsumoto; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Natsuko Ichiki; Sayaka Tao; Haruki Miyaji; Tsuyoshi Nishioku; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

Functional impact of RIMs on gating of voltage-dependent Ca2+channels
Junichi Matsumoto; Noriko Sumi; Tsuyoshi Nishioku; Shinya Dohgu; Shinsuke Nakagawa; Atsushi Yamauchi; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009

Involvement of the activated microglia in the induction of blood-brain barrier dysfunction
Noriko Sumi; Tsuyoshi Nishioku; Kotoe Asano; Junichi Matsumoto; Shinsuke Nakagawa; Atsushi Yamauchi; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008

精巣摘出によるテストステロン欠乏はPPE誘発の肺気腫形成を加速させる
青野 健太郎; 坂井 優菜; 松本 純一; 松本 太一; 三好 利奈; 右田 啓介; 道具 伸也; 山内 淳史
日本薬学会第141年会, 26 Mar. 2021, 日本薬学会

テストステロン補充は精巣摘出マウスにおけるPPE誘発の肺気腫形成を抑制する
坂井 優菜; 青野 健太郎; 松本 純一; 松本 太一; 三好 利奈; 右田 啓介; 道具 伸也; 山内 淳史
日本薬学会第141年会, 26 Mar. 2021, 日本薬学会

ボルテゾミブはタイトジャンクションの破綻を介して血管透過性を亢進する
松本 太一; 坂田 歩美; 松本 純一; 森山 英恵; 小野 和彦; 山内 淳史; 右田 啓介; 原 周司
日本薬学会第141年会, 26 Mar. 2021, 日本薬学会

加熱式たばこPloom TECH抽出物による血液脳関門障害
道具 伸也; 木村 郁哉; 江口 夏海; 力武 真衣; 高田 芙友子; 松本 純一; 岩尾 卓朗; 片岡 泰文
日本薬学会第141年会, 26 Mar. 2021, 日本薬学会

シクロスポリンによる脳ペリサイトのαシヌクレインオリゴマー分解促進
道具 伸也; 横谷 みき; 高田 芙友子; 松本 純一; 岩尾 卓朗; 佐野 和憲; 片岡 泰文
第94回日本薬理学会年会, 08 Mar. 2021, 日本薬理学会

脳ペリサイトはアストロサイトのNa+依存性グルタミン酸取り込みを促進的に調節する
高田 芙友子; 坂井 研太; 岩尾 卓朗; 松本 純一; 片岡 泰文; 山内 淳史; 道具 伸也
第94回日本薬理学会年会, 08 Mar. 2021, 日本薬理学会

血液脳関門(BBB)を介したドコサヘキサエン酸の脳移行は加齢マウスにおいて減少する。
岩尾 卓朗; 髙田 芙友子; 松本 純一; 片岡 泰文; 道具 伸也
第94回日本薬理学会年会, 08 Mar. 2021, 日本薬理学会

精巣摘出マウスにおけるテストステロン欠乏はエラスターゼ気管支内投与後の死亡率 とアンチプロテアーゼの発現プロファイルに変化を与える
青野 健太郎; 松本 純一; 三好 利奈; 坂井 優菜; 中川 慎介; 道具 伸也; 山内 淳史
第73回日本薬理学会西南部会, 21 Nov. 2020, 日本薬理学会

加齢により血液脳関門(BBB)を介したドコサヘキサエン酸の脳移行は減少する。
岩尾 卓朗; 髙田 芙友子; 松本 純一; 片岡 泰文; 道具 伸也
第73回日本薬理学会西南部会, 21 Nov. 2020, 日本薬理学会

COPDモデルマウスにおけるリポキシンA4に対するエストロゲンの影響
冨永 宏治; 青野 健太郎; 松本 純一; 古賀 允久; 山内 淳史; 江川 孝; 片岡 泰文
日本薬学会第140年会, 25 Mar. 2020, 日本薬学会

脳ペリサイトによるα-シヌクレインオリゴマーの細胞内取り込み機構
横谷 みき; 道具 伸也; 高田 芙友子; 松本 純一; 岩尾 卓朗; 山内 淳史; 佐野 和憲; 片岡 泰文
日本薬学会第140年会, 25 Mar. 2020, 日本薬学会

Serum amyloid AはTLRsを介して脳ペリサイトの炎症応答を調節する
松本 純一; 道具 伸也; 高田 芙友子; 岩尾 卓朗; 友廣 美咲; 平田 由佳; 青野 健太郎; 山内 淳史; 片岡 泰文
日本薬学会第140年会, 25 Mar. 2020, 日本薬学会

Toll様受容体を介した脳ペリサイト特異的なαシヌクレインによる炎症性メディエーター産生
道具 伸也; 秋月 美波; 小林 篤史; 盛田 隼矢; 高田 芙友子; 松本 純一; 岩尾 卓朗; 山内 淳史; 佐野 和憲; 片岡 泰文
第93回日本薬理学会年会, 16 Mar. 2020, 日本薬理学会

Serum amyloid Aによる血液脳関門障害とHigh density lipoproteinによる抑制作用
松本純一; 道具伸也; 高田芙友子; 岩尾卓朗; 友廣美咲; 片岡泰文; 山内淳史
第72回日本薬理学会西南部会, 16 Nov. 2019, 日本薬理学会

An interaction between thrombin and pericytes mediates the blood-brain barrier dysfunction in obesity-associated diabetes.
Fuyuko Takata; Shinya Dohgu; Takashi Machida; Junichi Matsumoto; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
cerebral vascular biology,, 28 Nov. 2018

Lowered PDGF-BB/PDGFRb signaling between brain endothelial cells and pericyte contributes to the blood-brain barrier disruption induced by oxygen-glucose deprivation.
Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Wakana Yoshida; Aya Yoshimatsu; Haruka Tanaka; Atsushi Yamauchi; Yasufumi Kataoka
Cerebral Vascular Biology, 28 Nov. 2017

α-Synuclein-reactive pericytes contribute to the blood-brain barrier dysfunction through the release of inflammatory cytokines in vitro.
Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
Cerebral Vascular Biology, 28 Nov. 2017

脳血管内皮細胞－ペリサイト細胞間PDGF-BB/PDGFRbシグナル減弱が低酸素・低グルコース誘発性血液脳関門機能障害に関与する
木村郁哉; 道具伸也; 高田芙友子; 松本純一; 吉田若菜; 吉松あや; 田中春花; 山内淳史; 片岡泰文
第70回日本薬理学会西南部会, Nov. 2017, 日本薬理学会

脳微小血管内皮細胞の7 nAChR活性化は、TNF-α刺激による密着結合蛋白量及び障壁能の低下を抑制する
木村郁哉; 道具伸也; 高田芙友子; 松本純一; 川原庸平; 西平恵; 坂田昇平; 最初拓也; 片岡泰文; 山内淳史
第90回日本薬理学会年会, 17 Mar. 2017, 日本薬理学会

TNF-α-stimulated brain pericytes activate microglia to induce inflammation at the neurovascular unit
Fuyuko Takata-Tsuji; Shinya Dohgu; Junichi Matsumoto; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
19th International Symposium on signal transduction at the Blood-Brain Barriers, 14 Sep. 2016

AMPK活性化を介したメトホルミンの血液脳関門機能強化作用
高田芙友子; 道具伸也; 松本純一; 町田崇; 山内淳史; 片岡泰文
第3回日本くすりと糖尿病学会学術集会, 02 Nov. 2014

日本薬学会

日本薬理学会

アンドロゲンシグナルから捉えるCOPD病態の解析と治療薬の探索
日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
福岡大学
01 Apr. 2022 - 31 Mar. 2025

アンドロゲンを核とする内分泌系－肺－脳の臓器連関異常化によるCOPD病態増悪機構
日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
福岡大学
01 Apr. 2021 - 31 Mar. 2024

血管透過性亢進に起因するボルテゾミブ誘発性肺障害の発症機序解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2021 - 31 Mar. 2024

腸炎症に起因した脳ペリサイト異常化が駆動する脳内αシヌクレインの凝集・蓄積亢進
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2019 - 31 Mar. 2022

エクソソームが駆動する慢性閉塞性肺疾患の血液脳関門病変化と薬剤中枢性副作用
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists
Fukuoka University
01 Apr. 2019 - 31 Mar. 2022

肥満症による末梢慢性炎症の脳内伝播過程において「鍵」となる脳ペリサイトの病変化
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2014 - 31 Mar. 2018

生活習慣病に起因する腸内細菌叢の変調・異常と脳内β-amyloid動態障害の解明
ヤクルト・バイオサイエンス研究財団, 研究助成金
01 Apr. 2015 - 31 Mar. 2016

慢性閉塞性肺疾患の血液脳関門病変化とレニン・アンジオテンシン系阻害薬の保護作用
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), 基盤研究(C)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2015

脳ペリサイト産生シクロフィリンＡによる脳インスリン抵抗性形成と糖尿病進展
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B)
Fukuoka University
2011 - 2013

脳ペリサイト機能異常に起因した脳神経血管機構破綻による肥満症の進展
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B)
Fukuoka University
2009 - 2010