Zfat is indispensable for the development of erythroid cells in the fetal liver.
Doi K; Tsunoda T; Koyanagi M; Tanaka Y; Yamano S; Fujikane A; Nishi K; Ishikura S; Shirasawa S
Anticancer Res., 2019年, 査読有り

Zfat expression in ZsGreen reporter gene knock-in mice: Implications for a novel function of Zfat in definitive erythropoiesis.
Tsunoda T; Doi K; Ishikura S; Luo H; Nishi K; Matsuzaki H; Koyanagi M; Tanaka Y; Okamura T; Shirasawa S
Int. J. Mol. Med., 2018年, 査読有り

Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS
Kensuke Nishi; Hao Luo; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Lauren Wills; George S. Baillie; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
ANTICANCER RESEARCH, 2017年07月, 査読有り

An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.
Kensuke Nishi; Hao Luo; Kazuhiko Nakabayashi; Keiko Doi; Shuhei Ishikura; Yuri Iwaihara; Yasuhiro Yoshida; Kumpei Tanisawa; Tomio Arai; Seijiro Mori; Motoji Sawabe; Masaaki Muramatsu; Masashi Tanaka; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, 2017年07月, 査読有り

ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line.
Nishi K. Iwaihara; Y. Tsunoda; T. Doi; K; Sakata; T. Shirasawa; S. Ishikura S
Cell Death Dis., 2017年, 査読有り

Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells
Shuhei Ishikura; Toshiyuki Tsunoda; Kazuhiko Nakabayashi; Keiko Doi; Midori Koyanagi; Keiko Hayashi; Tomoko Kawai; Yoko Tanaka; Yuri Iwaihara; Hao Luo; Kensuke Nishi; Tadashi Okamura; Senji Shirasawa
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2016年11月, 査読有り

Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells
Hao Luo; Masayo Umebayashi; Keiko Doi; Takashi Morisaki; Senji Shirasawa; Toshiyuki Tsunoda
ANTICANCER RESEARCH, 2016年07月, 査読有り

The nuclear zinc finger protein Zfat maintains FoxO1 protein levels in peripheral T cells by regulating activities of autophagy and Akt signaling pathway.
Ishikura S; Iwaihara Y; Tanaka Y; Luo H; Nishi K; Doi K; Koyanagi M; Okamura T; Tsunoda T; Shirasawa S
J Biol Chem, 2016年, 査読有り

Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells
Yuri Iwaihara; Shuhei Ishikura; Keiko Doi; Toshiyuki Tsunoda; Takahiro Fujimoto; Tadashi Okamura; Senji Shirasawa
ANTICANCER RESEARCH, 2015年08月, 査読有り

Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules
Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Hiromasa Hidesima; Hao Luo; Yumiko Hirose; Senji Shirasawa
ANTICANCER RESEARCH, 2015年08月, 査読有り

Zfat-Deficient CD4(+)CD8(+) Double-Positive Thymocytes Are Susceptible to Apoptosis With Deregulated Activation of p38 and JNK
Shuhei Ishikura; Masahiro Ogawa; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Yoko Tanaka; Toshiyuki Tsunoda; Hiromasa Hideshima; Tadashi Okamura; Senji Shirasawa
JOURNAL OF CELLULAR BIOCHEMISTRY, 2015年01月, 査読有り

The Roles of ZFAT in Thymocyte Differentiation and Homeostasis of Peripheral Naive T-Cells
Keiko Doi; Shuhei Ishikura; Senji Shirasawa
ANTICANCER RESEARCH, 2014年08月, 査読有り

Resveratrol Induces Luminal Apoptosis of Human Colorectal Cancer HCT116 Cells in Three-dimensional Culture
Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Senji Shirasawa
ANTICANCER RESEARCH, 2014年08月, 査読有り

Zfat-deficiency results in a loss of CD3 phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.
Ogawa M; Okamura T; Ishikura S; Doi K; Matsuzaki H; Tanaka Y; Ota T; Hayakawa K; Suzuki H; Tsunoda T; Sasazuki T; Shirasawa S
PLoS ONE, 2013年, 査読有り

ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response
Keiko Doi; Takahiro Fujimoto; Tadashi Okamura; Masahiro Ogawa; Yoko Tanaka; Yasumasa Mototani; Motohito Goto; Takeharu Ota; Hiroshi Matsuzaki; Masahide Kuroki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012年08月, 査読有り

Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model
Toshiyuki Tsunoda; Takeharu Ota; Takahiro Fujimoto; Keiko Doi; Yoko Tanaka; Yasuhiro Yoshida; Masahiro Ogawa; Hiroshi Matsuzaki; Masato Hamabashiri; Darren R. Tyson; Masahide Kuroki; Shingo Miyamoto; Senji Shirasawa
MOLECULAR CANCER, 2012年07月, 査読有り

ALPK2 is Crucial for Luminal Apoptosis and DNA Repair-related Gene Expression in a Three-dimensional Colonic-crypt Model
Yasuhiro Yoshida; Toshiyuki Tsunoda; Keiko Doi; Takahiro Fujimoto; Yoko Tanaka; Takeharu Ota; Masahiro Ogawa; Hiroshi Matsuzaki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
ANTICANCER RESEARCH, 2012年06月, 査読有り

KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells.
Ota T; Doi K; Fujimoto T; Tanaka Y; Ogawa M; Matsuzaki H; Kuroki M; Miyamoto S; Shirasawa S; Tsunoda T
Anticancer Res., 2012年, 査読有り

Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes
Hiroshi Matsuzaki; Takahiro Fujimoto; Takeharu Ota; Masahiro Ogawa; Toshiyuki Tsunoda; Keiko Doi; Masato Hamabashiri; Masatoshi Tanaka; Senji Shirasawa
FEBS OPEN BIO, 2012年, 査読有り

Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells
Toshiyuki Tsunoda; Yasuo Takashima; Yasuhiro Yoshida; Keiko Doi; Yoko Tanaka; Takahiro Fujimoto; Takashi Machida; Takeharu Ota; Midori Koyanagi; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
ANTICANCER RESEARCH, 2011年07月, 査読有り

KRAS-mediated Up-regulation of RRM2 Expression Is Essential for the Proliferation of Colorectal Cancer Cell Lines
Yasuhiro Yoshida; Toshiyuki Tsunoda; Keiko Doi; Yoko Tanaka; Takahiro Fujimoto; Takashi Machida; Takeharu Ota; Midori Koyanagi; Yasuo Takashima; Takehiko Sasazuki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
ANTICANCER RESEARCH, 2011年07月, 査読有り

KRAS-induced actin-interacting protein regulates inositol 1,4,5-trisphosphate-receptor-mediated calcium release
Takahiro Fujimoto; Takashi Machida; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Masahide Kuroki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011年05月, 査読有り

Determination of the critical region of KRAS-induced actin-interacting protein for the interaction with inositol 1,4,5-trisphosphate receptor
Takahiro Fujimoto; Takashi Machida; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Masahide Kuroki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011年05月, 査読有り

KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells
Takahiro Fujimoto; Takashi Machida; Yoko Tanaka; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Tadashi Okamura; Masahide Kuroki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011年04月, 査読有り

ZFAT IS A CRITICAL MOLECULE FOR CELL SURVIVAL IN MOUSE EMBRYONIC FIBROBLASTS
Keiko Doi; Takahiro Fujimoto; Midori Koyanagi; Toshiyuki Tsunoda; Yoko Tanaka; Yasuhiro Yoshida; Yasuo Takashima; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
CELLULAR & MOLECULAR BIOLOGY LETTERS, 2011年03月, 査読有り

ZFAT is essential for endothelial cell assembly and the branch point formation of capillary-like structures in an angiogenesis model
Yasuhiro Yoshida; Toshiyuki Tsunoda; Yasuo Takashima; Takahiro Fujimoto; Keiko Doi; Takehiko Sasazuki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
CELLULAR & MOLECULAR BIOLOGY LETTERS, 2010年12月, 査読有り

3D-specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model.
Tsunoda T; Takashima Y; Fujimoto T; Koyanagi M; Yoshida Y; Doi K; Tanaka Y; Kuroki M; Sasazuki T; Shirasawa S
Neoplasia, 2010年, 査読有り

Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands.
Tsunoda T; Takashima Y; Tanaka Y; Fujimoto T; Doi K; Hirose Y; Koyanagi M; Yoshida Y; Okamura T; Kuroki M; Sasazuki T; Shirasawa S
Proc. Natl. Acad. Sci. USA., 2010年, 査読有り

Elucidation of thermostabilizing mechanism in lysozyme-monomethoxypolyethylene glycol conjugate
Nodake, Y; Ikushima, A; Doi-Kawano, K; Sakakibara, R; Yamasaki, N
J.Integr.Stud.Diet.Habits., 2010年, 査読有り

Steady-State and Time-Resolved Fluorescence Spectroscopic Studies on Interaction of the N-terminal Region with the Hairpin Loop of the Phytocystain Scb
Keiko Doi-Kawano; Etsuko Nishimoto; Yoshiaki Kouzuma; Daisuke Takahashi; Shoji Yamashita; Makoto Kimura
JOURNAL OF FLUORESCENCE, 2009年07月

ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells
Takahiro Fujimoto; Keiko Doi; Midori Koyanagi; Toshiyuki Tsunoda; Yasuo Takashima; Yasuhiro Yoshida; Takehiko Sasazuki; Senji Shirasawa
FEBS LETTERS, 2009年02月, 査読有り

Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice.
Fujimoto T; Miyasaka K; Koyanagi M; Tsunoda T; Baba I; Doi K; Ohta M; Kato N; Sasazuki T; Shirasawa S
PLoS ONE., 2009年, 査読有り

ZFAT expression in B and T lymphocytes and identification of ZFAT-regulated genes
Midori Koyanagi; Kazuhiko Nakabayashi; Takahiro Fujimoto; Ning Gu; Iwai Baba; Yasuo Takashima; Keiko Doi; Haruhito Harada; Norihiro Kato; Takehiko Sasazuki; Senji Shirasawa
GENOMICS, 2008年05月, 査読有り

Functional Analysis of ZFAT through Specific siRNA against ZFAT in Ba/F3 cell Line
Koyanagi, M; Doi, K; Fujimoto, T; Tsunoda, T; Takashima, Y; Shirasawa S
Med.Bull.Fukuoka univ., 2008年, 査読有り

Controlled intracellular localization and enhanced antisense effect of oligonucleotides by chemical conjugation
T Kubo; Z Zhelev; B Rumiana; H Ohba; K Doi; M Fujii
ORGANIC & BIOMOLECULAR CHEMISTRY, 2005年, 査読有り

Suppression of bcr/abl chimeric gene by conjugate DNA enzymes in human cells
Takamori, K; Kubo, T; Zhelev, Z; Bakalova, R; Ohba, H; Doi, K; Fujii, M
Nucleic.Acids, Symposium Series, 2005年, 査読有り

Molecular cloning and functional expression of cDNA encoding the cysteine proteinase inhibitor Sca from sunflower seeds
Y Kouzuma; K Tsukigata; H Inanaga; K Doi-Kawano; N Yamasaki; M Kimura
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2001年04月, 査読有り

Molecular cloning and functional expression of cDNA encoding the cysteine proteinase inhibitor with three cystatin domains from sunflower seeds
Y Kouzuma; H Inanaga; K Doi-Kawano; N Yamasaki; M Kimura
JOURNAL OF BIOCHEMISTRY, 2000年08月, 査読有り

Molecular cloning, functional expression, and mutagenesis of cDNA encoding a cysteine proteinase inhibitor from sunflower seeds
K Doi-Kawano; Y Kouzuma; N Yamasaki; M Kimura
JOURNAL OF BIOCHEMISTRY, 1998年11月, 査読有り

Purification, Characterization, and Sequencin of Two Cystein Proteinase Inhibitors, Sca and Scb, from Sunflower (Helianthus annuus)Seeds
Kouzuma, Y; Kawano, K; Kimura, M; Yamasaki, N; Kadowaki, T; Yamamoto, K
J.Biochem., 1996年, 査読有り

マウス胎児肝臓の赤血球分化における転写制御分子Zfatの機能解析
日本人類遺伝学会 第64回大会, 2019年11月

T細胞における転写制御分子Zfatの機能発現機構の解明
第22回バイオ治療法研究会学術集会, 2018年12月

末梢T細胞のTCR刺激時における転写制御分子Zfatの機能メカニズムの解明
日本人類遺伝学会 第63回大会, 2018年10月

T細胞における転写制御分子ZFATの分子機構の解明
日本人類遺伝学会 第62回大会, 2017年11月

Identification of the genes regulated by ZFAT in T cells through ChIP-seq analysis.
第13回国際人類遺伝学会, 2016年03月

T細胞における免疫系転写制御分子Zfatの転写制御標的分子の同定
第19回バイオ治療法研究会学術集会, 2015年12月

ChIP-seq解析によるT細胞におけるZFATの転写制御標的分子の同定
日本人類遺伝学会 第60回大会, 2015年10月

ZFAT欠損CD4+CD8+ double positive胸腺細胞におけるアポトーシス感受性の亢進
日本人類遺伝学会 第59回大会, 2014年11月

転写制御分子ZFAT欠損による胸腺内T細胞分化異常に関するZFAT分子機序の解明
日本人類遺伝学会 第58回大会, 2013年11月

遺伝子改変マウスを利用した転写制御分子ZFATの機能解明
日本人類遺伝学会 第57回大会, 2012年10月

遺伝子欠損マウスを利用した新規転写制御因子ZFATの機能解明
土井佳子; 角田俊之; 高島康郎; 藤本崇宏; 田中陽子; 小柳緑; 吉田康浩; 笹月健彦; 白澤専二
日本人類遺伝学会第55回大会, 2010年10月

転写制御因子ZFATの機能および転写ネットワークに関する研究
土井佳子; 藤本崇宏; 小柳緑; 高島康郎; 角田俊之; 田中陽子; 吉田康浩; 中林一彦; 笹月健彦; 白澤専二
日本人類遺伝学会第54回大会, 2009年09月