Association of T cell infiltration and morphological change of thymus gland with the aggravation of pulmonary emphysema in testosterone deficiency.
Kentaro Aono; Junichi Matsumoto; Taichi Matsumoto; Mitsuhisa Koga; Keisuke Migita; Koji Tominaga; Shinsuke Nakagawa; Atsushi Yamauchi
Biochemistry and biophysics reports, Jul. 2023, 34:101489 - 101489

Bortezomib Increased Vascular Permeability by Decreasing Cell-Cell Junction Molecules in Human Pulmonary Microvascular Endothelial Cells.
Taichi Matsumoto; Junichi Matsumoto; Yuka Matsushita; Moeno Arimura; Kentaro Aono; Mikiko Aoki; Kazuki Terada; Masayoshi Mori; Yutaka Haramaki; Takuya Imatoh; Atsushi Yamauchi; Keisuke Migita
International journal of molecular sciences, 29 Jun. 2023, 24(13)

Moxifloxacin induces aortic aneurysm and dissection by increasing osteopontin in mice.
Koshun Inada; Mitsuhisa Koga; Ayano Yamada; Shinya Dohgu; Atsushi Yamauchi
Biochemical and biophysical research communications, 12 Nov. 2022, 629:1 - 5

Testosterone deficiency promotes the development of pulmonary emphysema in orchiectomized mice exposed to elastase.
Kentaro Aono; Junichi Matsumoto; Shinsuke Nakagawa; Taichi Matsumoto; Mitsuhisa Koga; Keisuke Migita; Koji Tominaga; Yuna Sakai; Atsushi Yamauchi
Biochemical and biophysical research communications, 18 Jun. 2021, 558:94 - 101, Refereed

Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice.
Kenta Sakai; Fuyuko Takata; Gaku Yamanaka; Miho Yasunaga; Kana Hashiguchi; Kazuki Tominaga; Kouichi Itoh; Yasufumi Kataoka; Atsushi Yamauchi; Shinya Dohgu
Journal of pharmacological sciences, Jan. 2021, 145(1):155 - 165, Refereed

Serum amyloid A-induced blood-brain barrier dysfunction associated with decreased claudin-5 expression in rat brain endothelial cells and its inhibition by high-density lipoprotein in vitro.
Junichi Matsumoto; Shinya Dohgu; Fuyuko Takata; Takuro Iwao; Ikuya Kimura; Misaki Tomohiro; Kentaro Aono; Yasufumi Kataoka; Atsushi Yamauchi
Neuroscience letters, 01 Nov. 2020, 738:135352 - 135352, Refereed

Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages.
Mitsuhisa Koga; Yuki Kanaoka; Koshun Inada; Sai Omine; Yasufumi Kataoka; Atsushi Yamauchi
J Pharmacol Sci., Jun. 2020, 143(2):106 - 111, Refereed

Oligodendrocytes upregulate blood-brain barrier function through mechanisms other than the PDGF-BB/PDGFRα pathway in the barrier-tightening effect of oligodendrocyte progenitor cells.
Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Takuro Iwao; Atsushi Yamauchi; Yasufumi Kataoka
Neurosci Lett., Jan. 2020, 715:134594 - 134594, Refereed

Varenicline aggravates atherosclerotic plaque formation in nicotine- pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression.
Mitsuhisa Koga; Yuki Kanaoka; Mana Okamoto; Yuki Nakao; Koshun Inada; Saki Takayama; Yasufumi Kataoka; Atsushi Yamauchi
J Pharmacol Sci., Jan. 2020, 142(1):9 - 15, Refereed

Oncostatin-M-Reactive Pericytes Aggravate Blood-Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro.
Takata F; Dohgu S; Sakaguchi S; Sakai K; Yamanaka G; Iwao T; Matsumoto J; Kimura I; Sezaki Y; Tanaka Y; Yamauchi A; Kataoka Y
Neuroscience, Nov. 2019, 422:12 - 20, Refereed

Monomeric α-synuclein induces blood-brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro.
Microvasc Res., Jul. 2019, 124:61 - 66, Refereed

Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells.
Neurosci Lett., Feb. 2019, 694:9 - 13, Refereed

Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro.
Takata F; Dohgu S; Matsumoto J; Machida T; Sakaguchi S; Kimura I; Yamauchi A; Kataoka Y
J Cell Biochem., Nov. 2018, 119(11):9055 - 9063

TNF-alpha-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IkappaB-NFkappaB and JAK-STAT3 pathways.
Matsumoto J; Dohgu S; Takata F; Machida T; Hatip FFB; Hatip-Al-Khatib I; Yamauchi A; Kataoka Y
Brain Res, 01 Aug. 2018, 1692:34 - 44

Effect of varenicline on behavioral deficits in a rat model of Parkinson's disease induced by unilateral 6-hydroxydopamine lesion of substantia nigra.
Behav. Pharmacol., Jun. 2018, 29:327 - 335, Refereed

Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson’s disease.
Nakashima A; Yamauchi A; Matsumoto J; Dohgu S; Takata F; Koga M; Fukae J; Tsuboi Y; Kataoka Y
Behav Pharmacol, 25 May 2018

Varenicline is a smoking cessation drug that blocks alveolar expansion in mice intratracheally administrated porcine pancreatic elastase.
Mitsuhisa Koga; Yuki Kanaoka; Tetsushi Tashiro; Nagisa Hashidume; Yasufumi Kataoka; Atsushi Yamauchi
J Pharmacol Sci., 20 Jan. 2018, 137(2):224 - 229, Refereed

Varenicline promotes endothelial cell migration by lowering vascular endothelial-cadherin levels via the activated α7 nicotinic acetylcholine receptor-mitogen activated protein kinase axis.
Mitsuhisa Koga; Yuki Kanaoka; Keita Sugiyama; Kaoru Ohishi; Yuka Ejima; Mami Hisanaga; Yasufumi Kataoka; Atsushi Yamauchi
TOXICOLOGY, Sep. 2017, 390:1 - 9, Refereed

Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model
Takashi Machida; Fuyuko Takata; Junichi Matsumoto; Tomoyuki Miyamura; Ryosuke Hirata; Ikuya Kimura; Yasufumi Kataoka; Shinya Dohgu; Atsushi Yamauchi
PLOS ONE, May 2017, 12(5):e0177447, Refereed

Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood-brain barrier dysfunction in vitro.
Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Ikuya Kimura; Mariko Koga; Keiko Nakamoto; Atsushi Yamauchi; Yasufumi Kataoka
NEUROSCIENCE, May 2017, 350:146 - 157, Refereed

Varenicline enhances oxidized LDL uptake by increasing expression of LOX-1 and CD36 scavenger receptors through α(7) nAChR in macrophages.
Yuki Kanaoka; Mitsuhisa Koga; Keita Sugiyama; Kaoru Ohishi; Yasufumi Kataoka; Atsushi Yamauchi
TOXICOLOGY, Apr. 2017, 380:62 - 71, Refereed

CD147 promotes the formation of functional osteoclasts through NFATc1 signalling
Tsuyoshi Nishioku; Mariko Terasawa; Misaki Baba; Atsushi Yamauchi; Yasufumi Kataoka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2016, 473(2):620 - 624, Refereed

Elevated permeability of the blood-brain barrier in mice intratracheally administered porcine pancreatic elastase
Fuyuko Takata; Koji Tominaga; Mitsuhisa Koga; Shinya Dohgu; Koujiro Futagami; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, Sep. 2015, 129(1):78 - 81, Refereed

Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood-brain barrier in vitro
Takashi Machida; Fuyuko Takata; Junichi Matsumoto; Hisayo Takenoshita; Ikuya Kimura; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Jul. 2015, 599:109 - 114, Refereed

Nifedipine Prevents Sodium Caprate-Induced Barrier Dysfunction in Human Epidermal Keratinocyte Cultures
Yoshihiro Uchino; Junichi Matsumoto; Takuya Watanabe; Masato Hamabashiri; Takashi Tsuchiya; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2015, 38(6):926 - 929, Refereed

Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons
Hiroyuki Takahashi; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2015, 457(4):532 - 537, Refereed

Tumor necrosis factor-α reduces beta-amyloid accumulation primarily by lowering cellular prion protein levels in a brain endothelial cell line
Yuki Yasutaka; Takuya Watanabe; Akio Nakashima; Junichi Matsumoto; Koujiro Futagami; Atsushi Yamauchi; Yasufumi Kataoka
FEBS LETTERS, Jan. 2015, 589(2):263 - 268, Refereed

Varenicline aggravates plaque formation through α7 nicotinic acetylcholine receptors in ApoE KO mice.
Mitsuhisa Koga; Yuki Kanaoka; Yuma Ohkido; Naoka Kubo; Kaoru Ohishi; Keita Sugiyama; Atsushi Yamauchi; Yasufumi Kataoka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2014, 455(3-4):194 - 197, Refereed

Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation.
Junichi Matsumoto; Fuyuko Takata; Takashi Machida; Hiroyuki Takahashi; Yuki Soejima; Miho Funakoshi; Koujiro Futagami; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Aug. 2014, 578:133 - 138, Refereed

Pentosan polysulfate treatment ameliorates motor function with increased serum soluble vascular cell adhesion molecule-1 in HTLV-1-associated neurologic disease
Tatsufumi Nakamura; Katsuya Satoh; Taku Fukuda; Ikuo Kinoshita; Yoshihiro Nishiura; Kunihiko Nagasato; Atsushi Yamauchi; Yasufumi Kataoka; Tadahiro Nakamura; Hitoshi Sasaki; Kenji Kumagai; Masami Niwa; Mitsuru Noguchi; Hideki Nakamura; Noriyuki Nishida; Atsushi Kawakami
JOURNAL OF NEUROVIROLOGY, Jun. 2014, 20(3):269 - 277, Refereed

BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances uptake of oxidized low density lipoprotein into peritoneal macrophages
Mitsuhisa Koga; Atsushi Yamauchi; Yuki Kanaoka; Ryusuke Jige; Anna Tsukamoto; Nao Teshima; Tsuyoshi Nishioku; Yasufumi Kataoka
JOURNAL OF INFLAMMATION-LONDON, Oct. 2013, 10(1):32, Refereed

Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells
Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Takashi Machida; Shuji Kaneshima; Mai Matsuo; Shinya Sakaguchi; Yuki Takeshige; Atsushi Yamauchi; Yasufumi Kataoka
Biochemical and Biophysical Research Communications, 19 Apr. 2013, 433(4):586 - 590, Refereed

Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4
Takuya Watanabe; Shinya Dohgu; Fuyuko Takata; Tsuyoshi Nishioku; Akio Nakashima; Koujiro Futagami; Atsushi Yamauchi; Yasufumi Kataoka
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 2013, 36(3):492 - 495, Refereed

In Vitro Blood-Brain Barrier Models Using Brain Capillary Endothelial Cells Isolated from Neonatal and Adult Rats Retain Age-Related Barrier Properties
Fuyuko Takata; Shinya Dohgu; Atsushi Yamauchi; Junichi Matsumoto; Takashi Machida; Kayoko Fujishita; Keisuke Shibata; Youichi Shinozaki; Kaoru Sato; Yasufumi Kataoka; Schuichi Koizumi
PLoS ONE, 31 Jan. 2013, 8(1):e55166, Refereed

In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.
Takata F; Dohgu S; Yamauchi A; Matsumoto J; Machida T; Fujishita K; Shibata K; Shinozaki Y; Sato K; Kataoka Y; Koizumi S
PLoS One., 2013, 8(1):e55166, Refereed

Atorvastatin stimulates neuroblastoma cells to induce neurite outgrowth by increasing cellular prion protein expression
Takuya Watanabe; Yuki Yasutaka; Tsuyoshi Nishioku; Akio Nakashima; Koujiro Futagami; Atsushi Yamauchi; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Dec. 2012, 531(2):114 - 119, Refereed

Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis
Tsuyoshi Nishioku; Shinya Dohgu; Mitsuhisa Koga; Takashi Machida; Takuya Watanabe; Teppei Miura; Kousuke Tsumagari; Mariko Terasawa; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF INFLAMMATION-LONDON, Nov. 2012, 9(1):44, Refereed

Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells
Junichi Matsumoto; Shinya Dohgu; Fuyuko Takata; Tsuyoshi Nishioku; Noriko Sumi; Takashi Machida; Hiroyuki Takahashi; Atsushi Yamauchi; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Aug. 2012, 524(1):45 - 48, Refereed

A Role for Hypothalamic AMP-Activated Protein Kinase in the Mediation of Hyperphagia and Weight Gain Induced by Chronic Treatment with Olanzapine in Female Rats
Ei Sejima; Atsushi Yamauchi; Tsuyoshi Nishioku; Mitsuhisa Koga; Kengo Nakagama; Shinya Dohgu; Kojiro Futagami; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, Oct. 2011, 31(7):985 - 989, Refereed

Vascular dysfunction and impaired insulin signaling in high-fat diet fed ovariectomized mice
Koji Tominaga; Atsushi Yamauchi; Takashi Egawa; Ryosuke Tanaka; Satoko Kawahara; Hideki Shuto; Yasufumi Kataoka
MICROVASCULAR RESEARCH, Sep. 2011, 82(2):171 - 176, Refereed

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro.
Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Hiroyuki Takahashi; Takashi Machida; Tomoya Wakigawa; Eriko Harada; Haruki Miyaji; Mitsuhisa Koga; Tsuyoshi Nishioku; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF NEUROINFLAMMATION, Aug. 2011, 8:106, Refereed

POTENTIAL ROLE FOR S100A4 IN THE DISRUPTION OF THE BLOOD-BRAIN BARRIER IN COLLAGEN-INDUCED ARTHRITIC MICE, AN ANIMAL MODEL OF RHEUMATOID ARTHRITIS
T. Nishioku; K. Furusho; A. Tomita; H. Ohishi; S. Dohgu; H. Shuto; A. Yamauchi; Y. Kataoka
NEUROSCIENCE, Aug. 2011, 189:286 - 292, Refereed

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro.
Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Hiroyuki Takahashi; Takashi Machida; Tomoya Wakigawa; Eriko Harada; Haruki Miyaji; Mitsuhisa Koga; Tsuyoshi Nishioku; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF NEUROINFLAMMATION, Aug. 2011, 8(8):106, Refereed

Involvement of the cellular prion protein in the migration of brain microvascular endothelial cells
Takuya Watanabe; Yuki Yasutaka; Tsuyoshi Nishioku; Sae Kusakabe; Koujiro Futagami; Atsushi Yamauchi; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Jun. 2011, 496(2):121 - 124, Refereed

Partial hepatectomy aggravates cyclosporin A-induced neurotoxicity by lowering the function of the blood-brain barrier in mice
Atsushi Yamauchi; Shinya Dohgu; Fuyuko Takata; Takuya Watanabe; Tsuyoshi Nishioku; Junich Matsumoto; Yuka Ohkubo; Hideki Shuto; Yasufumi Kataoka
LIFE SCIENCES, Mar. 2011, 88(11-12):529 - 534, Refereed

The statins fluvastatin and pravastatin exert anti-flushing effects by improving vasomotor dysfunction through nitric oxide-mediated mechanisms in ovariectomized animals
Hideki Shuto; Koji Tominaga; Atsushi Yamauchi; Munehiko Ikeda; Kenji Kusaba; Daisuke Mitsunaga; Yasutoshi Hirabara; Takashi Egawa; Yukio Takano; Yasufumi Kataoka
EUROPEAN JOURNAL OF PHARMACOLOGY, Jan. 2011, 651(1-3):234 - 239, Refereed

Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1
Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Masatoshi Oda; Eriko Harada; Takuya Watanabe; Tsuyoshi Nishioku; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
MICROVASCULAR RESEARCH, Jan. 2011, 81(1):103 - 107, Refereed

Disruption of the blood-brain barrier in collagen-induced arthritic mice
Tsuyoshi Nishioku; Atsushi Yamauchi; Fuyuko Takata; Takuya Watanabe; Koki Furusho; Hideki Shuto; Shinya Dohgu; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Oct. 2010, 482(3):208 - 211, Refereed

Cyclosporin A induces hyperpermeability of the blood-brain barrier by inhibiting autocrine adrenomedullin-mediated up-regulation of endothelial barrier function
Shinya Dohgu; Noriko Sumi; Tsuyoshi Nishioku; Fuyuko Takata; Takuya Watanabe; Mikihiko Naito; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
EUROPEAN JOURNAL OF PHARMACOLOGY, Oct. 2010, 644(1-3):5 - 9, Refereed

Medication use as a risk factor for inpatient falls in an acute care hospital: a case-crossover study
Hideki Shuto; Osamu Imakyure; Junichi Matsumoto; Takashi Egawa; Ying Jiang; Masaaki Hirakawa; Yasufumi Kataoka; Takashi Yanagawa
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, May 2010, 69(5):535 - 542, Refereed

Sodium pentosan polysulfate resulted in cartilage improvement in knee osteoarthritis - An open clinical trial-
Kenji Kumagai; Susumu Shirabe; Noriaki Miyata; Masakazu Murata; Atsushi Yamauchi; Yasuhumi Kataoka; Masami Niwa
BMC Clinical Pharmacology, 28 Mar. 2010, 10:7, Refereed

Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood-Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia
Noriko Sumi; Tsuyoshi Nishioku; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Hideki Shuto; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, Mar. 2010, 30(2):247 - 253, Refereed

Tumor Necrosis Factor-alpha Mediates the Blood-Brain Barrier Dysfunction Induced by Activated Microglia in Mouse Brain Microvascular Endothelial Cells
Tsuyoshi Nishioku; Junichi Matsumoto; Shinya Dohgu; Noriko Sumi; Kenji Miyao; Fuyuko Takata; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, Feb. 2010, 112(2):251 - 254, Refereed

Disruption of the blood-brain barrier in collagen-induced arthritic mice
Koki Furusho; Tsuyoshi Nishioku; Teppei Miura; Ayano Tomita; Shinya Dohgu; Fuyuko Takata; Takuya Watanabe; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112(3):108P - 108P, Refereed

Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model
Hitomi Sejima; Koji Tominaga; Takashi Egawa; Munehiko Ikeda; Kohta Shibuya; Natsuko Kameyama; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
EUROPEAN JOURNAL OF PHARMACOLOGY, Dec. 2009, 624(1-3):66 - 70, Refereed

Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood-Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice
Tsuyoshi Nishioku; Shinya Dohgu; Fuyuko Takata; Tomoaki Eto; Naoko Ishikawa; Kota B. Kodama; Shinsuke Nakagawa; Atsushi Yamauchi; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, May 2009, 29(3):309 - 316, Refereed

Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice
Naoko Ishikawa; Tsuyoshi Nishioku; Shinya Dohgu; Fuyuko Takata; Kota Kodama; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109:270P - 270P, Refereed

Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells
Tomoya Wakigawa; Fuyuko Takata; Shinya Dohgu; Eriko Harada; Kousuke Matumoto; Takasi Obara; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109(2):251P - 251P, Refereed

Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway
Fuyuko Takata; Shinya Dohgu; Tsuyoshi Nishioku; Hiroyuki Takahashi; Eriko Harada; Ikuko Makino; Manabu Nakashima; Atsushi Yamauchi; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Jan. 2009, 449(1):71 - 75, Refereed

Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells
Fuyuko Takata; Noriko Sumi; Tsuyoshi Nishioku; Eriko Harada; Tomoya Wakigawa; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
Neuroscience Letters, 22 Aug. 2008, 441(2):163 - 166

Selective serotonin reuptake inhibitors fluvoxamine and paroxetine restore forced exercise-induced temperature dysregulation in ovariectomized mice
Munehiko Ikeda; Takashi Egawa; Atsushi Yamauchi; Yoshio Sohda; Ayako Koga; Kohji Tominaga; Hideki Shuto; Yasufumi Kataoka
EUROPEAN JOURNAL OF PHARMACOLOGY, Jan. 2008, 579(1-3):439 - 444, Refereed

Adverse effect of cyclosporin a on barrier functions of cerebral microvascular endothelial cells after hypoxia-reoxygenation damage in vitro
Shinya Dohgu; Tsuyoshi Nishioku; Noriko Sumi; Fuyuko Takata; Shinsuke Nakagawa; Mikihiko Naito; Takashi Tsuruo; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, Nov. 2007, 27(7):889 - 899, Refereed

Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier
Fuyuko Takata; Shinya Dohgu; Atsushi Yamauchi; Noriko Sumi; Shinsuke Nakagawa; Mikihiko Naito; Takashi Tsuruo; Hideki Shuto; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, May 2007, 27(3):317 - 328, Refereed

An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function
Atsushi Yamauchi; Shinya Dohgu; Tsuyoshi Nishioku; Hideki Shuto; Mikihiko Naito; Takashi Tsuruo; Yasufumi Sawada; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, May 2007, 27(3):263 - 270, Refereed

Protective action of indapamide, a thiazide-like diuretic, on ischemia-induced injury and barrier dysfunction in mouse brain microvascular endothelial cells
Tsuyoshi Nishioku; Fuyuko Takata; Atsushi Yamauchi; Noriko Sumi; Ikumi Yamamoto; Akiko Fujino; Mikihiko Naito; Takashi Tsuruo; Hideki Shuto; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2007, 103(3):323 - 327, Refereed

HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier
Kentaro Hayashi; Hong Pu; Ibolya E. Andras; Sung Yong Eum; Atsushi Yamauchi; Bernhard Hennig; Michal Toborek
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Aug. 2006, 26(8):1052 - 1065, Refereed

Cell-cycle-dependent pharmacology of methotrexate in HL-60
A Yamauchi; T Ichimiya; K Inoue; Y Taguchi; N Matsunaga; S Koyanagi; T Fukagawa; H Aramaki; S Higuchi; S Ohdo
JOURNAL OF PHARMACOLOGICAL SCIENCES, Dec. 2005, 99(4):335 - 341, Refereed

Cyclosporin a aggravates electroshock-induced convulsions in mice with a transient middle cerebral artery occlusion
A Yamauchi; H Shuto; S Dohgu; Y Nakano; T Egawa; Y Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, Aug. 2005, 25(5):923 - 928, Refereed

Forced exercise-induced flushing of tail skin in ovariectomized mice, as a new experimental model of menopausal hot flushes
H Shuto; A Yamauchi; M Ikeda; Y Sohda; A Koga; K Tominaga; T Egawa; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2005, 98(3):323 - 326, Refereed

Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production
S Dohgu; F Takata; A Yamauchi; S Nakagawa; T Egawa; M Naito; T Tsuruo; Y Sawada; M Niwa; Y Kataoka
BRAIN RESEARCH, Mar. 2005, 1038(2):208 - 215, Refereed

難治性ネフローゼ症候群に対するLDLアフェレシスの効果 －陰性荷電LDLとシクロスポリン薬物動態の解析－
小河原悟; 安部泰弘; 村田敏晃; 笹冨佳江; 齋藤喬雄; 張波; 朔啓二郎; 山内淳史; 片岡泰文
ICUとCCU 別冊号, 2005, Vol.29:S115 - S117

Toxicity of quinacrine can be reduced by Co-administration of p-glycoprotein inhibitor in sporadic Creutzfeldt-Jakob disease
K Satoh; S Shirabe; K Eguchi; A Yamauchi; Y Kataoka; M Niwa; N Nishida; S Katamine
CELLULAR AND MOLECULAR NEUROBIOLOGY, Dec. 2004, 24(6):873 - 875, Refereed

Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes
S Dohgu; A Yamauchi; S Nakagawa; F Takata; M Kai; T Egawa; M Naito; T Tsuruo; Y Sawada; M Niwa; Y Kataoka
EUROPEAN JOURNAL OF PHARMACOLOGY, Nov. 2004, 505(1-3):51 - 59, Refereed

Tacrolimus-induced neurotoxicity and nephrotoxicity is ameliorated by administration in the dark phase in rats
A Yamauchi; R Oishi; Y Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, Oct. 2004, 24(5):695 - 704, Refereed

Soybean isoflavones eliminate nifedipine-induced flushing of tail skin in ovariectomized mice
M Kai; A Yamauchi; K Tominaga; A Koga; H Kai; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, Aug. 2004, 95(4):476 - 478, Refereed

Transforming growth factor-beta 1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells
S Dohgu; A Yamauchi; F Takata; M Naito; T Tsuruo; S Higuchi; Y Sawada; Y Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, Jun. 2004, 24(3):491 - 497, Refereed

Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier
S Dohgu; A Yamauchi; F Takata; Y Sawada; S Higuchi; M Naito; T Tsuruo; S Shirabe; M Niwa; S Katamine; Y Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, Apr. 2004, 24(2):205 - 217, Refereed

Results of quinacrine administration to patients with Creutzfeldt-Jakob disease
M Nakajima; T Yamada; T Kusuhara; H Furukawa; M Takahashi; A Yamauchi; Y Kataoka
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2004, 17(3):158 - 163, Refereed

Ovariectomy aggravates nifedipine-induced flushing of tail skin in mice
M Kai; K Tominaga; K Okimoto; A Yamauchi; H Kai; Y Kataoka
EUROPEAN JOURNAL OF PHARMACOLOGY, Nov. 2003, 481(1):79 - 82, Refereed

Cell kinetics-dependent antitumor effect of irinotecan hydrochloride induced by the synchronizing effect of hydroxyurea: cell kinetics and dosing time
T Akagi; K Ushinohama; Y Kage; T Ishizaki; T Makinosumi; A Yamauchi; Y Taguchi; K Inoue; E Yukawa; S Higuchi; S Ohdo
LIFE SCIENCES, Jan. 2003, 72(10):1183 - 1197, Refereed

Subchronic treatment with cyclosporin A decreases the binding properties of the GABA(A) receptor in ovariectomized rats
K Tominaga; M Kai; A Yamauchi; S Dohgu; K Toda; R Oishi; Y Kataoka
LIFE SCIENCES, Dec. 2002, 72(4-5):425 - 430, Refereed

Cyclosporine A-increased nitric oxide production in the rat dorsal hippocampus mediates convulsions
Y Fujisaki; A Yamauchi; S Dohgu; K Sunada; C Yamaguchi; R Oishi; Y Kataoka
LIFE SCIENCES, Dec. 2002, 72(4-5):549 - 556, Refereed

Neurotoxicity induced by tacrolimus after liver transplantation: Relation to genetic polymorphisms of the ABCB1 (MDR1) gene
A Yamauchi; Ieiri, I; Y Kataoka; M Tanabe; T Nishizaki; R Oishi; S Higuchi; K Otsubo; K Sugimachi
TRANSPLANTATION, Aug. 2002, 74(4):571 - 573, Refereed

Nasal glucagon delivery using microcrystalline cellulose in healthy volunteers
D Teshima; A Yamauchi; K Makino; Y Kataoka; Y Arita; H Nawata; R Oishi
INTERNATIONAL JOURNAL OF PHARMACEUTICS, Feb. 2002, 233(1-2):61 - 66, Refereed

Contrast media increase vascular endothelial permeability by inhibiting nitric-oxide production
W Furuta; A Yamauchi; S Dohgu; S Nakagawa; T Sendo; K Makino; R Oishi; Y Kataoka
INVESTIGATIVE RADIOLOGY, Jan. 2002, 37(1):13 - 19, Refereed

Ovariectomy aggravates convulsions and hippocampal gamma-aminobutyric acid inhibition induced by cyclosporin A in rats
K Tominaga; A Yamauchi; H Shuto; M Niizeki; K Makino; R Oishi; Y Kataoka
EUROPEAN JOURNAL OF PHARMACOLOGY, Nov. 2001, 430(2-3):243 - 249, Refereed

Pharmacological characterization of cyclosporine A-induced kaolin intake in rats
Y Fujisaki; A Yamauchi; H Shuto; M Niizeki; K Makino; Y Kataoka; R Oishi
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, Oct. 2001, 70(2-3):267 - 271, Refereed

A leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y was not identified in the Japanese population
K Makino; Y Kataoka; Y Hirakawa; A Ikeda; A Yamauchi; R Oishi
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, Jun. 2001, 26(3):201 - 203, Refereed

COPDモデルマウスにおけるリポキシンA4に対するエストロゲンの影響
冨永 宏治; 青野 健太郎; 松本 純一; 古賀 允久; 山内 淳史; 江川 孝; 片岡 泰文
日本薬学会年会要旨集, Mar. 2020, 140年会:26Q - pm097

バレニクリンはマクロファージにおける酸化LDLによる泡沫化を促進する
金岡 祐輝; 古賀 允久; 山内 淳史; 片岡 泰文
日本薬学会年会要旨集, Mar. 2016, 136年会(3):70 - 70

バレニクリンによるα7nAChRを介する動脈硬化巣形成の増悪作用
金岡 祐輝; 古賀 允久; 大石 かおる; 杉山 慶太; 江島 優佳; 久永 真未; 山内 淳史; 片岡 泰文
日本薬学会年会要旨集, Mar. 2015, 135年会(3):129 - 129

Nicotinic acetylcholine receptors modulate TNF-alpha-induced MMP-9 release from brain pericytes
Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124:209P - 209P

糖尿病併発による動脈硬化巣の形成過程におけるBMP4の役割
古賀 允久; 金岡 祐輝; 地下 隆介; 西奥 剛; 山内 淳史; 片岡 泰文
日本薬理学雑誌, Mar. 2013, 141(3):45P - 45P

Brain pericyte-derived soluble factors induce the blood-brain barrier dysfunction under pathological conditions
Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Hiroyuki Takahashi; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121:25P - 25P

Alpha7 nicotinic acetylcholine receptor mediates MMP-9 release from brain pericytes
Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Atsushi Noriyuki; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121:215P - 215P

Brain pericytes contribute to the blood-brain barrier disruption induced by thrombin
Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hisayo Takenoshita; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121:214P - 214P

S100A4 is a causative factor for disruption of the blood-brain barrier in collagen-induced arthritic mice
Tsuyoshi Nishioku; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118:152P - 152P

Brain pericytes-specific TNF-alpha-induced MMP-9 release is mediated by ROS and delayed activation of ERK1/2 and Akt
Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Haruki Miyaji; Yui Sonogi; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118:111P - 111P

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-alpha, releasing matrix metalloproteinase-9 and migrating in vitro
Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Takashi Machida; Hiroyuki Takahashi; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118:112P - 112P

Brain pericytes prevent migration of the inflammatory cells across the blood-brain barrier
Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Takashi Machida; Natsuko Ichiki; Natsuko Seki; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118:111P - 111P

Brain pericytes among BBB cells possess the most sensitive machinery of TNF-a - MMP-9 pathway due to high expression levels of TNF-R2 and long-lasting activation of ERK1/2 and Akt
Haruki Miyaji; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Yui Sonogi; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:186P - 186P

TNF-alpha-induced release of IL-6 from brain pericytes through JAK/STAT signaling pathway
Sayaka Tao; Junichi Matsumoto; Fuyuko Takata; Hiroyuki Takahashi; Manami Kawaguchi; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:176P - 176P

Brain pericytes release matrix metalloproteinase-9 in response to brain endothelial cells-derived ectonucleotidase CD39/ENTPDase1 under hypoxia/aglycemia condition
Tatsuya Furuno; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Tomo Nanri; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:140P - 140P

Brain pericytes prevents migration of the inflammatory cells across the blood-brain barrier
Natsuko Ichiki; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Natsuko Seki; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:242P - 242P

Brain pericytes facilitate insulin-induced phosphorylation of Akt in the hypothalamic neuronal cells
Hiroyuki Takahashi; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:189P - 189P

Effect of olanzapine on lipid metabolisms mediated by AMPK-SREBP signaling in the hepatocytes (HepG2 cells)
Sayako Eguchi; Hirotomo Uematsu; Ei Sejima; Yu Oshima; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:144P - 144P

Calcineurin/NFAT signaling regulates MMP-9 expression in brain pericytes
Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Tatsuya Fruno; Shuji Kaneshima; Takuya Watanabe; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:55P - 55P

Reactive oxygen species (ROS)-mediated regulation of MMP-9 expression in the brain pericytes
Kousuke Matsumoto; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Natsuko Ichiki; Sayaka Tao; Haruki Miyaji; Tsuyoshi Nishioku; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:189P - 189P

BBB hyperpermeability to sodium fluorescein in obese mice with impaired glucose tolerance induced by high-fat diet
Fuyuko Takata; Shinya Dohgu; Takashi Obara; Junichi Matsumoto; Tsuyoshi Nishioku; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:127P - 127P

A role of hypothalamic AMP-activated protein kinase in the mediation of olanzapine-induced hyperphagia and weight-gain in female rats
Kengo Nakagama; Ei Sejima; Atsushi Yamauchi; Keiichi Fujimoto; Mako Toyoda; Hideki Shutou; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:225P - 225P

Influence of olanzapine on glycogen metabolism in HepG2 cells
Keiichi Fujimoto; Ei Sejima; Atsushi Yamauchi; Kengo Nakagama; Mako Toyoda; Hideki Shutou; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:181P - 181P

Sodium pentosan polysulfate brought about cartilage improvement in knee osteoarthritis - An open clinical trial-.
Kumagai K; Shirabe S; Miyata N; Murata M; Yamauchi A; Kataoka Y; Niwa M
BMC Clinical Pharmacology, 2010, 10(7)

Population Pharmacokinetics and Dose Adjustment Strategy of Cyclosporine in Steroid-resistant Nephrotic Patients
Satoru Ogahara; Takao Saito; Masayo Ueno; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka; Tomohiro Sasaki; Ichiro Ieiri; Shun Higuchi
THERAPEUTIC DRUG MONITORING, Oct. 2009, 31(5):656 - 656

Functional impact of RIMs on gating of voltage-dependent Ca2+channels
Junichi Matsumoto; Noriko Sumi; Tsuyoshi Nishioku; Shinya Dohgu; Shinsuke Nakagawa; Atsushi Yamauchi; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109:159P - 159P

Effect of olanzapine on glucose transport system in 3T3-L1 adipocytes
Mako Toyoda; Atsushi Yamauchi; Kengo Nakagama; Keichi Fujimoto; Ei Sejima; Hideki Shuto; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109:149P - 149P

アドレノメデュリンによる脳血管周皮細胞ペリサイトの弛緩作用 脳微細循環調節機構の解明を目指して
原田 枝理子; 高田 芙友子; 湧川 朝也; 西奥 剛; 角 典子; 児玉 耕太; 山内 淳史; 中川 慎介; 首藤 英樹; 丹羽 正美; 片岡 泰文
日本薬理学雑誌, Mar. 2008, 131(3):48p - 48p

Involvement of the activated microglia in the induction of blood-brain barrier dysfunction
Noriko Sumi; Tsuyoshi Nishioku; Kotoe Asano; Junichi Matsumoto; Shinsuke Nakagawa; Atsushi Yamauchi; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:126P - 126P

Time-course of morphological alterations of pericytes in the blood-brain barrier disruption
Naoko Ishikawa; Tsuyoshi Nishioku; Noriko Sumi; Hiromi Nakanishi; Atsushi Yamauchi; Shinsuke Nakagawa; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:127P - 127P

Olanzapine-lowers gastrointestinal absorption of glucose in female rats
Yo Aoyama; Ei Sejima; Fusako Motoyama; Mako Toyoda; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:146P - 146P

Involvement of brain pericytes in tacrolimus (TCL)-induced dysfunction of the blood-brain barrier (BBB)
Fuyuko Takata; Eriko Harada; Shinsuke Nakagawa; Tomoya Wakigawa; Sachiyo Hashiguchi; Atsushi Yamauchi; Hideki Shuto; Maria A. Deli; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:51P - 51P

Involvement of microglia in the induction of blood-brain barrier dysfunction
Kenji Miyao; Tsuyoshi Nishioku; Fuyuko Takata; Noriko Sumi; Atsushi Yamauchi; Shinsuke Nakagawa; Maria A. Deli; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103:177P - 177P

Protective effect of adrenomedullin on lipopolysaccharide-induced blood-brain barrier dysfunction
Noriko Sumi; Tsuyoshi Nishioku; Fuyuko Takata; Atsushi Yamauchi; Shinsuke Nakagawa; Maria A. Deli; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103:178P - 178P

Relaxation of cultured rat brain pericytes after stimulation with adrenomedullin
Hiroyuki Takahashi; Fuyuko Takata; Tsuyoshi Nishioku; Atsushi Yamauchi; Noriko Sumi; Shinsuke Nakagawa; Maria A. Deli; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103:178P - 178P

Immunohistochemical analysis of pericytes in the blood-brain barrier disruption
Tomoaki Eto; Tsuyoshi Nishioku; Fuyuko Takata; Atsushi Yamauchi; Shinnsuke Nakagawa; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103:178P - 178P

The brain pericyte-derived transforming growth factor-beta (TGF-beta) upregulates the blood-brain barrier function
F Takata; S Dohgu; A Yamauchi; N Sumi; S Nakagawa; M Niwa; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, 97:213P - 213P

Cyclosporin A induces dysfunction of the blood-brain barrier by inhibiting adrenomedullin signal transduction in mouse brain endothelial cells
N Sumi; S Dohgu; A Yamauchi; F Takata; S Nakagawa; M Niwa; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, 97:213P - 213P

Clinical trial of quinacrine in patients with Creulzfeldt-Jakob disease and experimental evidences for its uptake and efflux at the blood-brain barrier (BBB)
M Ueno; A Yamauchi; S Dohgu; S Shirabe; S Katamine; M Niwa; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94:286P - 286P

Involvement of brain pericytes in cyclosporin A-induced dysfunction of the blood-brain barrier
F Takata; S Dohgu; A Yamauchi; M Niwa; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94:89P - 89P

Cyclosporin A transports across the pathologically reconstituted blood-brain barrier (BBB) after an exposure to hypoxic condition
S Dohgu; F Takata; A Yamauchi; M Niwa; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94:287P - 287P

Establishment of in vitro human blood-brain barrier (BBB) model with human peripheral microvessel Endothelial cells (HMVEC)
S Nakagawa; S Dohgu; A Yamauchi; M Niwa; Y Kataoka; R Oishi
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, 88:283P - 283P

図解 薬害・副作用学 改訂2版
Joint work
南山堂, Sep. 2017

薬の生体内運命 改訂7版
Joint work
ネオメディカル, Mar. 2017

スタンダード薬学シリーズⅡ6 Ⅰ.薬の作用と体の変化および薬理・病態・薬物治療（1）
東京化学同人, Oct. 2015

新編プログラム学習による病態と処方解析
Joint work
廣川書店, Mar. 2013

スタンダード薬学シリーズ6 薬と疾病 Ⅲ.薬物治療(2)および薬物治療に役立つ情報 第2版
東京化学同人, Dec. 2012

プログラム学習による処方解析学
Joint work
廣川書店, Sep. 2004

薬物動態・作用と遺伝子多型
Joint work
医薬ジャーナル社, Sep. 2001

慢性閉塞性肺疾患COPD併存うつ病の治療薬による原疾患増悪ジレンマのメカニズム
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2024 - 31 Mar. 2027

アンドロゲンシグナルから捉えるCOPD病態の解析と治療薬の探索
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2022 - 31 Mar. 2025

アンドロゲンを核とする内分泌系－肺－脳の臓器連関異常化によるCOPD病態増悪機構
学術振興会, 基盤研究(C)
01 Apr. 2021 - 31 Mar. 2023

飲酒量低減薬ナルメフェンによる動脈硬化症の発症機序
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2020 - 31 Mar. 2023

高尿酸血症病態における禁煙補助薬バレニクリンによる動脈硬化進展の加速・増悪機序
基盤研究C 一般
01 Apr. 2018 - 31 Mar. 2021

SAA/LXA4バランスにより制御される慢性閉塞性肺疾患のエストロゲンによる変容
基盤研究C 一般
01 Apr. 2017 - 31 Mar. 2020

脳ペリサイトを基軸としたαシヌクレインによる血液脳関門－脳神経の連動的障害発現
基盤研究C 一般
01 Apr. 2016 - 31 Mar. 2019

尿酸-P2X7受容体-GSK3β経路によるパーキンソン病の発症・進展制御機構
基盤研究C 一般
01 Apr. 2015 - 31 Mar. 2018

シクロフィリンA-CD147シグナルを基盤とした脳血管性認知症の白質病変形成機構
基盤研究C 一般
01 Apr. 2013 - 31 Mar. 2016

慢性閉塞性肺疾患の血液脳関門病変化とレニン・アンジオテンシン系阻害薬の保護作用
基盤研究C 一般
01 Apr. 2012 - 31 Mar. 2015

代謝センサー分子AMPKに着目した統合失調症治療薬誘発エネルギー代謝異常発現機序
若手研究B
01 Apr. 2009 - 31 Mar. 2011

肥満病態におけるアディポサイトカインによる血液脳関門機能の制御機構
若手研究B
01 Apr. 2007 - 31 Mar. 2009

関節リウマチの免疫抑制薬療法：中枢・腎有害作用の分子機構解析と安全性対策の構築
基盤研究B 一般
01 Apr. 2005 - 31 Mar. 2008

更年期微細循環調節障害の新しい評価法の確立
萌芽研究
01 Apr. 2004 - 31 Mar. 2006

免疫抑制薬の中枢毒性：発現機序解明とこれを基盤とした副作用関連遺伝子の探索
基盤研究B 一般
01 Apr. 2002 - 31 Mar. 2005