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Last Updated :2024/12/22



Department of Phatmaceutics
Professor

Profile1991年 九州大学医学部卒業 1991年 九州大学医学部第3内科入局 1998年 フランスIGBMC研究所(Paolo Sassone-Corsi博士研究室) 2003年 米国マイアミ前田明博士研究室 2005年 九州大学病院・内分泌代謝糖尿病科 助教 2007年 藤田保健衛生大学・総合医科学研究所・准教授 2012年 名古屋大学大学院医学系研究科・神経遺伝情報学・特任助教 2013年 京都大学大学院形態形成機構学教室       健康長寿社会の総合医療開発ユニット 特定講師 2016年 福岡大学薬学部臨床薬物治療学・准教授

Researcher information

■ Degree
  • 医学博士, 九州大学
■ Research Keyword
  • 遺伝子
  • 選択的スプライシング
  • エストロゲン受容体
  • 乳癌
  • U1 snRNP
  • 内分泌

Career

■ Career
  • Apr. 2016
    福岡大学薬学部, 臨床薬物治療学, 准教授
  • Mar. 2013
    京都大学・形態形成機構学, 健康長寿社会の総合医療開発ユニット, 特定講師
  • Mar. 2012 - Feb. 2013
    名古屋大学大学院・医学系研究科, 神経遺伝情報学, GCOE特任助教
  • Jul. 2007 - Feb. 2012
    藤田保健衛生大学, 准教授
  • Jun. 2005 - Jun. 2007
    九州大学病院・内分泌糖尿病内科, 助教
■ Educational Background
  • 01 Apr. 1993 - 31 Mar. 1997
    Kyushu University, 大学院医学研究科, 内科系専攻
  • 01 Apr. 1985 - 31 Mar. 1991
    Kyushu University, Faculty of Medicine

Research activity information

■ Paper
  • Continuous psychosocial stress stimulates BMP signaling in dorsal hippocampus concomitant with anxiety-like behavior associated with differential modulation of cell proliferation and neurogenesis
    Mori M; Murata Y; Tsuchihashi M; Hanakita N; Terasaki F; Harada H; Kawanabe S; Terada K; Matsumoto T; Ohe K; Mine K; Enjoji M
    Behav Brain Res., 24 May 2020, 112711, Refereed
  • Dysregulated Lipid Metabolism and Lipid Accumulation in Colorectal Neoplasms
    Enjoji M; Ishihara H; Hirano A; Murata Y; Yada R; Nakamuta M; Imamura K; Hisabe T; Ohe K; Yao K
    Journal of Comprehensive Cancer Research, Aug. 2019, 3:1 - 8, Refereed
  • Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of 18F- fluorodeoxyglucose in sporadic paraganglioma: A case report
    Terada E; Ashida K; Ohe K; Sakamoto S; Hasuzawa N; Nomura M
    Clin Case Rep, Jul. 2019, 7:1399 - 1403, Refereed
  • A self-monitoring urinary salt excretion level measurement device for educating young women about salt reduction: A parallel randomized trial involving two groups.
    Kenichiro Yasutake; Yoko Umeki; Noriko Horita; Rieko Morita; Yusuke Murata; Kenji Ohe; Takuya Tsuchihashi; Munechika Enjoji
    Journal of clinical hypertension (Greenwich, Conn.), Jun. 2019, 21(6):730 - 738, Refereed
  • Maternal folic acid depletion during early pregnancy increases sensitivity to squamous tumor formation in the offspring in mice
    Kawakubo-Yasukochi T; Morioka M; Ohe K; Yasukochi A; Ozaki Y; Hazekawa M; Nishinakagawa T; Ono K; Nakamura S; Nakashima M
    J Dev Orig Hlth Dis, May 2019, 21:730 - 738
  • Two cases of mitochondrial diabetes in which pancreatic beta-cell function and neuropathy were improved by glucagon-like peptide-1 receptor agonist therapy
    Minezaki M; Abe I; Koga M; Sugimoto K; Takeshita K; Takahara S; Nakagawa M; Fujii H; Ohishi H; Kudo T; Ohe K; Yanase T; Kobayashi K
    J Endocrinol Metab, Apr. 2019, 9:33 - 36, Refereed
  • Circular IRE-type RNAs of the NR5A1 gene are formed in adrenocortical cells
    Ohe K; Tanaka T; Horita Y; Harada Y; Yamasaki T; Abe I; Tanabe M; Nomiyama T; Kobayashi K; Enjoji M; Yanase T
    Biochem Biophys Res Commun., Mar. 2019, 512:1 - 6
  • Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma
    Abe I; Fujii H; Ohishi H; Sugimoto K; Minezaki M; Nakagawa M; Takahara S; Kudo T; Abe M; Ohe K; Yanase T; Kobayashi K
    Endocr J., 28 Feb. 2019, 66(2):187 - 192, Refereed
  • Chronic administration of quetiapine stimulates dorsal hippocampal proliferation and immature neurons of male rats, but does not reverse psychosocial stress-induced hyponeophagic behavior
    Murata Y; Matsuda H; Mikami Y; Hirose S; Mori M; Ohe K; Mine K; Enjoji M
    Psychiatry Res, Feb. 2019, 272:411 - 418
  • A case of nivolumab-induced acute-onset type 1 diabetes mellitus in melanoma
    Sakaguchi C; Ashida K; Yano S; Ohe K; Nagata H; Wada N; Hasuzawa N; Matsuda Y; Sakamoto S; Sakamoto R; Uchi H; Furue M; Ogawa Y; Nomura M
    Curr Oncol., Feb. 2019, 26:e115 - e118, Refereed
  • Acute exacerbation of chronic adrenal insufficiency caused by ipilimumab: a case report of melanoma
    Sakaguchi C; Yano S; Ashida K; Wada N; Ohe K; Nagata H; Terada E; Matsuda Y; Sakamoto S; Sakamoto R; Ohnaka K; Uchi H; Furue M; Nomura M; Ogawa Y
    Am J Case Rep, Jan. 2019, 20:106 - 110, Refereed
  • A case of autonomous cortisol secretion in a patient with subclinical Cushing’s syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone
    Sakaguchi C; Ashida K; Kohashi K; Ohe K; Fujii Y; Yano S; Matsuda Y; Sakamoto S; Sakamoto R; Oda Y; Nomura M; Ogawa Y
    BMC Endocr Disord, Jan. 2019, 19:13, Refereed
  • A novel micro-RNA feedback loop of high-mobility group protein A1a in regulating estrogen receptor alpha-alternative splicing
    Ohe K; Harada Y; Horita Y; Harada H; Terai H; Mori M; Murata Y; Ashida K; Enjoji M
    Biomed J Sci&Tech Res, Nov. 2018, 11:BJSTR. MS.ID.002058
  • Non-coding RNAs and steroidogenesis
    Ohe K; Harada Y; Harada H; Terai H; Mori M; Murata Y; Enjoji M
    Biomed J Sci&Tech Res, Oct. 2018, 11:BJSTR. MS.ID.001910
  • Clinical Investigation of Adrenal Incidentalomas in Japanese Patients of the Fukuoka Region with Updated Diagnostic Criteria for Sub-clinical Cushing's Syndrome
    Abe I; Sugimoto K; Miyajima T; Ide T; Minezaki M; Takeshita K; Takahara S; Nakagawa M; Fujimura Y; Kudo T; Miyajima S; Taira H; Ohe K; Ishii T; Yanase T; Kobayashi K
    Intern Med., Sep. 2018, 57(17):2467 - 2472, Refereed
  • HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells
    Ohe K; Miyajima S; Tanaka T; Hamaguchi Y; Harada Y; Horita Y; Beppu Y; Ito F; Yamasaki T; Terai H; Mori M; Murata Y; Tanabe M; Ashida K; Enjoji M; Yanase T; Harada N; Utsumi T; Mayeda A
    J Steroid Biochem Mol Biol, Aug. 2018, 182:21 - 26
  • Nutritional dietary approach for NAFLD: carbohydrate restriction or fat restriction
    Yasutake K; Ohe K; Imai K; Murata Y; Enjoji M
    Gastroenterol Pancreatol Liver Disord, Aug. 2018, 6:1 - 7
  • Enhanced antitumor effects and delivery profiles of menahydroquinone-4 prodrugs with ionic or nonionic promoiety to hepatocellular carcinoma cells
    Setoguchi S; Watase D; Matsunaga K; Yamakawa H; Goto S; Terada K; Ohe K; Enjoji M; Karube Y; Takata J
    Molecules, Jul. 2018, 23:E1738, Refereed
  • Asynchronous Rhythm of Ad4BP/SF-1 and Per2 Expression in Adrenal Tumors of Cushing’s Syndrome
    Ohe K; Tanaka T; Terai H; Mori M; Murata Y; Enjoji M; Yanase T
    Biomed J Sci&Tech Res, Jul. 2018, 7:BJSTR. MS.ID.001459
  • 持続的な睡眠剥奪によるラット海馬の細胞増殖および未成熟新生ニューロンの減少は、背側腹側の両側で見られる
    Yusuke Murata; Ayana Oka; Ayaka Iseki; Masayoshi Mori; Kenji Ohe; Kazunori Mine; Munechika Enjoji
    Neuroscience Research, 01 Jun. 2018, 131:45 - 51, Refereed
  • HMGA1a induces alternative splicing of the Estrogen Receptor-alpha gene by trapping U1 snRNP to an upstream pseudo-5’ splice site
    Ohe K; Miyajima S; Tanaka T; Hamaguchi Y; Harada Y; Horita Y; Beppu Y; Ito F; Yamasaki T; Terai H; Mori M; Murata Y; Abe I; Tanabe M; Ashida K; Kobayashi K; Enjoji M; Nomiyama T; Yanase T; Harada N; Utsumi T; Mayeda M
    Front Mol Biosci, Jun. 2018, 5:52, Refereed
  • Nivolumab-induced thyroid dysfunction lacking antithyroid antibody is frequently evoked in Japanese patients with malignant melanoma.
    Yano S; Ashida K; Nagata H; Ohe K; Wada N; Takeichi Y; Hanada Y; Ibayashi Y; Wang L; Sakamoto S; Sakamoto R; Uchi H; Shiratsuchi M; Furue M; Nomura M; Ogawa Y
    BMC Endocrine Disorders, Jun. 2018, 18(1):36 - 41
  • Relevance of the Mini Nutritional Assessment in cirrhotic liver disease patients.
    Yasutake K; Koga S; Hokko Y; Ikemoto M; Yaguchi Y; Sakai H; Murata Y; Ohe K; Kohjima M; Nakamuta M; Enjoji M
    Asia Pac J Clin Nutr, Feb. 2018, Refereed
  • Self-monitoring of urinary salt excretion as a method of salt- reduction education: a parallel, randomized trial involving two groups
    Yasutake K; Miyoshi E; Misumi Y; Kajiyama T; Fukuda T; Ishii T; Moriguchi R; Murata Y; Ohe K; Enjoji M; Tsuchihashi T
    Public Health Nutr, Feb. 2018, 21:2164 - 2173, Refereed
  • Change of oral to topical corticosteroid therapy exacerbated glucose tolerance in a patient with plaque psoriasis
    Yui Hongo; Kenji Ashida; Kenji Ohe; Munechika Enjoji; Miyuki Yamaguchi; Tsuyoshi Kurata; Akiko Emoto; Hiroko Yamanouchi; Satoko Takagi; Hitoe Mori; Nozomi Kawata; Yoshio Hisata; Yuta Sakanishi; Kenichi Izumi; Takashi Sugioka; Keizo Anzai
    American Journal of Case Reports, 13 Nov. 2017, 18:1198 - 1203, Refereed
  • Interannual study of spot urine–evaluated sodium excretion in young Japanese women.
    Kenichiro Yasutake; Ririko Moriguchi; Tomomi Kajiyama; Hitomi Miyazaki; Shimako Abe; Takashi Masuda; Katsumi Imai; Masako Iwamoto; Hiroko Tsuda; Masayo Obe; Hisaya Kawate; Hiromi Ueno; Misaki Ono; Ryoko Goromaru; Kenji Ohe; Munechika Enjoji; Takuya Tsuchihashi; Shuji Nakano
    JOURNAL OF CLINICAL HYPERTENSION, Jul. 2017, 19(7):653 - 660, Refereed
  • Sodium and potassium urinary excretion levels of preschool children: individual, daily and seasonal differences.
    Yasutake K; Nagafuchi M; Izu R; Kajiyama T; Murata Y; Ohe K; Enjoji M; Tsuchihashi T
    The Journal of Clinical Hypertension, Jun. 2017, Refereed
  • RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the IKBKAP gene of familial dysautonomia.
    Ohe K; Yoshida M; Nakano-Kobayashi A; Hosokawa M; Sako Y; Sakuma M; Okuno Y; Usui T; Ninomiya K; Nojima T; Kataoka N; Hagiwara M
    RNA, Jun. 2017
  • Assessment of dietary salt and sodium intake: from device to questionnaire
    Ohe K; Yasutake K; Murata Y; Tsuchihashi T; Enjoji M
    Qual Prim Care, Jun. 2017, 25:101 - 108, Refereed
  • Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy
    Yukiya Sako; Kensuke Ninomiya; Yukiko Okuno; Masayasu Toyomoto; Atsushi Nishida; Yuka Koike; Kenji Ohe; Isao Kii; Suguru Yoshida; Naohiro Hashimoto; Takamitsu Hosoya; Masafumi Matsuo; Masatoshi Hagiwara
    SCIENTIFIC REPORTS, May 2017, 7
  • 高脂肪食誘発性肥満マウスにおける海馬神経新生の減少は、Communication Box法を用いたマイルドな心理的ストレスにより増悪する
    Yusuke Murata; Yukiyasu Narisawa; Rima Shimono; Hiraku Ohmori; Masayoshi Mori; Kenji Ohe; Kazunori Mine; Munechika Enjoji
    JOURNAL OF AFFECTIVE DISORDERS, Feb. 2017, 209:209 - 216, Refereed
  • Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms
    Mohammad Nazim; Akio Masuda; Mohammad Alinoor Rahman; Farhana Nasrin; Jun-Ichi Takeda; Kenji Ohe; Bisei Ohkawara; Mikako Ito; Kinji Ohno
    NUCLEIC ACIDS RESEARCH, Feb. 2017, 45(3):1455 - 1468
  • How and why do lipid droplets accumulate in gastric epithelial neoplasms?
    Enjoji M; Kohjima M; Ohe K; Yao K
    Ann Pharmacol Pharm, Jan. 2017, 2:1016, Refereed
  • How is lipid accumulation formed in gastric epithelial neoplasms?
    Enjoji M; Ohe K; Yao K
    Annals of Pharmacology & Pharmaceutics, 2017
  • Assessment of dietary salt and sodium intake: from questionnaire to device.
    Ohe K; Yasutake K; Murata Y; Tsuchihashi T; Enjoji M
    Quality in Primary Care, 2017
  • Comparison of a salt check sheet with 24-h urinary salt excretion measurement in local residents
    Kenichiro Yasutake; Emiko Miyoshi; Tomomi Kajiyama; Yoko Umeki; Yukiko Misumi; Noriko Horita; Yusuke Murata; Kenji Ohe; Munechika Enjoji; Takuya Tsuchihashi
    HYPERTENSION RESEARCH, Dec. 2016, 39(12):879 - 885
  • All-oral treatment with daclatasvir and asunaprevir for HCV genotype 1 and impact of add-on therapy with lipid modulators
    Kohjima M; Motomura K; Koyanagi T; Tada S; Yamashita N; Sato T; Nagase S; Sugimoto R; Yokota M; Uchimura K; Sakai H; Higashi N; Morizono S; Kuniyoshi M; Tokumatsu M; Honda M; Yoshimoto T; Higuchi N; Fukuizumi K; Kotoh K; Ohe K; Enjoji M; Kato M; Nakamuta M
    Adv Res Gastroenterol Hepatol, Oct. 2016, 2:555579, Refereed
  • Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia
    Mayumi Yoshida; Naoyuki Kataoka; Kenjyo Miyauchi; Kenji Ohe; Kei Iida; Suguru Yoshida; Takayuki Nojima; Yukiko Okuno; Hiroshi Onogi; Tomomi Usui; Akihide Takeuchi; Takamitsu Hosoya; Tsutomu Suzuki; Masatoshi Hagiwara
    Proceedings of the National Academy of Sciences of the United States of America, 2015, accepted, Refereed
  • Identification of a gene associated with autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study
    Manabu Funayama; Kenji Ohe; Taku Amo; Norihiko Furuya; Junji Yamaguchi; Shinji Saiki; Yuanzhe Li; Kotaro Ogaki; Maya Ando; Hiroyo Yoshino; Hiroyuki Tomiyama; Kenya Nishioka; Kazuko Hasegawa; Hidemoto Saiki; Wataru Satake; Kaoru Mogushi; Ryogen Sasaki; Yasumasa Kokubo; Shigeki Kuzuhara; Tatsushi Toda; Yoshikuni Mizuno; Yasuo Uchiyama; Kinji Ohno; Nobutaka Hattori
    The Lancet Neurology, 2015, accepted, Refereed
  • Modulation of alternative splicing with chemical compounds in new therapeutics for human diseases
    Kenji Ohe; Hagiwara Masatoshi
    ACS Chemical Biology, 2015, accepted, Refereed
  • HnRNP C, YB-1 and hnRNP L coordinately enhance skipping of human MUSK exon 10 to generate a Wnt-insensitive MuSK isoform.
    Nasrin F; Rahman MA; Masuda A; Ohe K; Takeda J; Ohno K
    Sci. Rep., 2014, 4:6841, Refereed
  • Nested introns in an intron: Evidence of multi-step splicing in a large intron of the human dystrophin pre-mRNA
    Hitoshi Suzuki; Toshiki Kameyama; Kenji Ohe; Toshifumi Tsukahara; Akila Mayeda
    FEBS Letters, 18 Mar. 2013, 587(6):555 - 561, Refereed
  • HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA.
    Rahman MA; Masuda A; Ohe K; Ito M; Hutchinson DO; Mayeda A; Engel AG; Ohno K
    Sci. Rep., 2013, 3:2931, Refereed
  • Intronic and exonic nucleotide variations that affect RNA splicing in humans
    Kenji Ohe; Akio Masuda; Kinji Ohno
    iConcept Press (Sequence and Genome Analysis I), 2013, Refereed
  • Evidence of multi-step splicing in a large intron of the human dystrophin pre-mRNA.
    Suzuki H; Kameyama T; Ohe K; Tsukahara T; Mayeda A
    FEBS Letters, 2013, 587(6):555 - 561, Refereed
  • HMGA1a is involved in specific splice site regulation of human immunodeficiency virus type 1
    Chikayuki Tsuruno; Kenji Ohe; Madoka Kuramitsu; Takuya Kohma; Youichi Takahama; Yukio Hamaguchi; Isao Hamaguchi; Kazu Okuma
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2011, 406(4):512 - 517, Refereed
  • HMGA1a Trapping of U1 snRNP at an Authentic 5 ' Splice Site Induces Aberrant Exon Skipping in Sporadic Alzheimer's Disease
    Kenji Ohe; Akila Mayeda
    MOLECULAR AND CELLULAR BIOLOGY, May 2010, 30(9):2220 - 2228, Refereed
  • DAX-1 and SOX6 Molecular Interplay Results in an Antagonistic Effect in Pre-mRNA Splicing
    Kenji Ohe; Katherine T. Tamai; Martti Parvinen; Paolo Sassone-Corsi
    DEVELOPMENTAL DYNAMICS, Jun. 2009, 238(6):1595 - 1604, Refereed
  • Methylation of a conserved intronic CpG island of mouse SF-1 is associated with cell-specific expression of SF-1 in a culture system but not with tissue-specific expression
    Hisao Shirohzu; Taijiro Okabe; Shigeki Gondo; Tomoko Tanaka; Kenji Ohe; Hidetaka Morinaga; Hisaya Kawate; Masatoshi Nomura; Ryoichi Takayanagi; Hajime Nawata; Toshihiko Yanase
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2008, 369(3):862 - 867, Refereed
  • PPNADに乳腺線維腺腫を合併し、Carney complexが疑われた一例
    野田哲平; 阿部一朗; 坂本竜一; 渡邊哲博; 権藤重喜; 大江賢治; 野村政壽; 岡部泰二郎; 柳瀬敏彦; 高柳涼一
    ホルモンと臨床(春季増刊)56:127-132, Mar. 2008, 56:127 - 132, Refereed
  • Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells
    Tanaka T; Gondo S; Okabe T; Ohe K; Shirohzu H; Morinaga H; Nomura M; Tani K; Takayanagi R; Nawata H; Yanase T
    J Mol Endocrinol, Nov. 2007, 9:343 - 350, Refereed
  • HMGA1a: sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of presenilin-2 pre-mRNA
    Takayuki Manabe; Kenji Ohe; Taiichi Katayama; Shinsuke Matsuzaki; Takeshi Yanagita; Hiroaki Okuda; Yoshio Bando; Kazunori Imaizumi; Raymond Reeves; Masaya Tohyama; Akila Mayeda
    GENES TO CELLS, Oct. 2007, 12(10):1179 - 1191, Refereed
  • 単心室症に褐色細胞腫を合併した2例
    阿部一朗; 野村政壽; 坂本竜一; 渡邉哲博; 権藤重喜; 大江賢治; 岡部泰二郎; 柳瀬敏彦; 高柳涼一
    日本内科学会雑誌 96:994-996, May 2007, 96:994 - 996, Refereed
  • 末端肥大症, 副腎皮質腫瘍及び直腸カルチノイドを合併し, 低レニン性高血圧症を呈したMEN I亜型の1例
    古閑靖章; 大江賢治; 權藤重喜; 渡辺哲博; 坂本竜一; 野村政壽; 岡部泰二郎; 川副信行; 笹野公伸; 柳瀬敏彦
    日本内科学会雑誌 95:2298-2301, Nov. 2006, 95:2298 - 2301, Refereed
  • Differentiation and regeneration of adrenal tissues: An initial step toward regeneration therapy for steroid insufficiency
    Toshihiko Yanase; Shigeki Gondo; Taijiro Okabe; Tomko Tanaka; Hisao Shirohzu; Wuqiang Fan; Koichi Oba; Hidetaka Morinaga; Masatoshi Nomura; Kenji Ohe; Hajime Nawata
    ENDOCRINE JOURNAL, Aug. 2006, 53(4):449 - 459, Refereed
  • [Primary cortisol resistance].
    Ohe K; Yanase T
    Nippon rinsho. Japanese journal of clinical medicine, May 2006, Suppl 1:574 - 577
  • Sexy splicing: regulatory interplays governing sex determination from Drosophila to mammals
    E Lalli; K Ohe; E Latorre; ME Bianchi; P Sassone-Corsi
    JOURNAL OF CELL SCIENCE, Feb. 2003, 116(3):441 - 445, Refereed
  • A direct role of SRY and SOX proteins in pre-mRNA splicing.
    Ohe K; Lalli E; Sassone-Corsi P
    Proc. Natl. Acad. Sci. U.S.A., 2002, 99(3):1146 - 1151, Refereed
  • Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA.
    Lalli E; Ohe K; Hindelang C; Sassone-Corsi P
    Mol. Cell. Biol., 2000, 20(13):4910 - 4921, Refereed
  • Nicotinamide potentiates TSHR and MHC class II promoter activity in FRTL-5 cells
    K Ohe; S Ikuyama; R Takayanagi; LD Kohn; H Nawata
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, Mar. 1999, 149(1-2):141 - 151
  • 甲状腺乳頭癌,腎細胞癌,子宮筋腫を合併した末端肥大症に下垂体のGH/PRL/ACTH産生腫瘍を認めた1例
    大江賢治; 後藤公宣; 生山祥一郎; 柳瀬敏彦; 高柳涼一; 名和田新
    ホルモンと臨床(内分泌興味ある症例)冬季増刊, Nov. 1998, 46:35 - 40, Refereed
  • Low level of glucocorticoid receptor messenger ribonucleic acid in pituitary adenomas manifesting Cushing's disease with resistance to a high dose dexamethasone suppression test
    YM Mu; R Takayanagi; K Imasaki; K Ohe; S Ikuyama; T Yanase; H Nawata
    CLINICAL ENDOCRINOLOGY, Sep. 1998, 49(3):301 - 306
  • Expression of an orphan nuclear receptor DAX-1 in human pituitary adenomas
    Ikuyama S; Mu YM; Ohe K; Nakagaki H; Fukushima T; Takayanagi R; Nawata H
    Cinical Endocrinology (Oxf), May 1998, 49:301 - 306, Refereed
  • 臨床医学の展望「内分泌学」
    名和田新; 高柳涼一; 柳瀬敏彦; 生山祥一郎; 後藤公宣; 大江賢治; 下田聖子; 足立雅広; 大庭功一; 蘆田健二; 市野功; 船越顕博; 井口東郎
    日本醫亊新報, Jan. 1998, 3859:10 - 20, Refereed
  • Cloning and characterization of the 4.2 kb region of the rat thyrotropin receptor promoter
    S Ikuyama; K Ohe; R Takayanagi; LD Kohn; H Nawata
    ENDOCRINE JOURNAL, Apr. 1997, 44(2):247 - 256, Refereed
  • 臨床医学の展望「内分泌学」
    名和田新; 高柳涼一; 柳瀬敏彦; 生山祥一郎; 後藤公宣; 大江賢治; 下田聖子; 足立雅広; 大庭功一; 蘆田健二; 市野功; 船越顕博; 井口東郎
    日本醫亊新報, Jan. 1997, 3800:8 - 19, Refereed
  • Follicle stimulating hormone-beta subunit gene is expressed in parallel with a transcription factor Ad4BP/SF-1 in human pituitary adenomas
    S Ikuyama; K Ohe; Y Sakai; H Nakagaki; T Fukushima; Y Kato; K Morohashi; R Takayanagi; H Nawata
    CLINICAL ENDOCRINOLOGY, Aug. 1996, 45(2):187 - 193, Refereed
  • Interferon-gamma suppresses thyrotropin receptor promoter activity by reducing thyroid transcription factor-1 (TTF-1) binding to its recognition site.
    Ohe K; Ikuyama S; Takayanagi R; Kohn LD; Nawata H
    Mol. Endocrinol., Jul. 1996, 10(7):826 - 836, Refereed
  • New mutations of DAX-1 genes in two Japanese patients with X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism
    T Yanase; R Takayanagi; K Oba; Y Nishi; KJ Ohe; HJ Nawata
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Feb. 1996, 81(2):530 - 535, Refereed
  • TYPE-1 ANGIOTENSIN-II RECEPTORS OF ADRENAL-TUMORS
    H NAWATA; R TAKAYANAGI; K OHNAKA; Y SAKAI; K IMASAKI; T YANASE; S IKUYAMA; S TANAKA; K OHE
    STEROIDS, Jan. 1995, 60(1):28 - 34, Refereed
  • 赤血球増多症を合併した悪性褐色細胞腫の1例
    大江賢治; 嘉川裕康; 生山祥一郎; 柳瀬敏彦; 高柳涼一; 名和田新
    ホルモンと臨床(内分泌興味ある症例)増刊号, Aug. 1994, 42:210 - 214, Refereed
  • 胸水貯留で発症したCD7陽性急性骨髄性白血病の1例
    大江賢治; 岡村孝; 有馬文統; 嘉村巧; 高松泰; 村川昌弘; 岡村精一; 原田実根; 仁保喜之
    臨床血液, Jun. 1994, 35:552 - 556, Refereed
  • 化学療法と放射線療法を試みた副腎原発angioendothelial lymphomaの1剖検例
    久野千津子; 浅野嘉延; 大江賢治; 松原不二夫; 岡本修; 白石元治; 大久保英雄
    臨床血液, May 1994, 35:506 - 510
  • 低ゴナドトロピン性性腺機能低下症を合併したAddison病の1例
    大江賢治; 古藤和浩; 大中圭三; 柳瀬敏彦; 辻裕二; 勝野誠; 高柳涼一; 土師正文; 名和田新
    日本内科学会雑誌, Jun. 1993, 82:125 - 127, Refereed
■ Books and other publications
  • 原発性コルチゾール抵抗症.内分泌症候群(第3版)Ⅱ-その他の内分泌疾患を含めて-
    Single work
    日本臨牀, Nov. 2018
  • 家族性自律神経失調症の治療薬候補
    大江賢治; 萩原正敏
    医学のあゆみ 257:318-319, Apr. 2016
  • 選択的スプライシング・ネットワークを化合物で操作する
    大江賢治; 萩原正敏
    Mar. 2015
  • 生体の科学 特集「細胞を化学で観察する・操作する」66(2)
    金原一郎医学医療振興財団, 2015
  • 「生体の科学」第66巻5号 特集 細胞シグナル操作法 II. 機能からみたシグナル操作法 1.遺伝子・ゲノム
    大江賢治; 飯田慶; 萩原正敏
    金原一郎医学医療振興財団, 2015
  • 選択的スプライシングを標的とした低分子化合物の医薬品開発 BIO Clinica 29(3)
    大江賢治; 萩原正敏, Joint work
    北隆館/ニュー・サイエンス社, 2014
  • 男性化徴候.病気と薬パーフェクトBOOK 2012(横田千津子他編)
    南山堂, Mar. 2012
  • 男性化徴候.病気と薬パーフェクトBOOK 2011(横田千津子他編)
    Single work
    南山堂, Mar. 2011
  • 男性化徴候.病気と薬パーフェクトBOOK 2010(横田千津子他編)
    南山堂, Mar. 2010
  • がん遺伝子産物HMGA1aがひき起こす孤発性アルツハイマー病の異常スプライシング (mRNAプログラム--多様性と非対称性の獲得戦略) -- (疾患とRNA)
    前田 明; 眞部 孝幸; 大江 賢治
    共立出版, Dec. 2009
  • 男性化徴候.病気と薬パーフェクトBOOK 2009(横田千津子他編)
    680-682
    南山堂, Mar. 2009
  • 癌と選択的スプライシング
    大江賢治
    Oct. 2008
  • 男性化徴候.病気と薬パーフェクトBOOK 2008(横田千津子他編)
    Single work, 600-602
    南山堂, Mar. 2008
  • 副腎腫瘍 診断ピットフォール―症例から学ぶ―
    大江賢治
    Jun. 2007
  • 内分泌症候群(第2版)Ⅰ
    大江賢治; 柳瀬敏彦, Joint work, 原発性コルチゾール抵抗症
    日本臨床社, 2006
  • 講義録 内分泌・代謝学(寺本民生・片山茂裕/編)
    大江賢治; 柳瀬敏彦
    メジカルビュー社, Oct. 2005
  • DAX-1と遺伝病--DAX-1変異蛋白の折り畳み異常による核内移行の障害 (あゆみ 核内オーファン受容体--最新トピックス)
    大江 賢治; 柳瀬 敏彦; 名和田 新
    医歯薬出版, Jun. 2005
  • RNAがわかる 多彩な生命現象を司るRNAの機能からRNAi、創薬への応用まで わかる実験医学シリーズ
    前田明; 大江賢治, 基本編 第2章 RNAのプロセッシング
    羊土社, 2003
  • ステロイドホルモン過敏症と抵抗性。アレルギー・免疫 Vol.6, No.1, P.29-35
    大江賢治; 名和田新, Joint work
    医薬ジャーナル社, 1998
■ Lectures, oral presentations, etc.
  • Identification of RNA-binding proteins responsible for aberrant tissue-specific splicing of the IKBKAP gene in Familial dysautonomia
    Kenji Ohe; Mayumi Yoshida; Akiko Nakano-Kobayashi; Kensuke Ninomiya; Maki Sakuma; Tomomi Usui; Takayuki Nojima; Naoyuki Kataoka; Masatoshi Hagiwara
    EUKARYOTIC mRNA PROCESSING meeting 2015, Cold Spring Harbor Laboratory, 2015
  • HMGA1a induces aberrant splicing of estrogen receptor α in MCF-7 breast cancer cells
    Ohe K; Utsumi T; Mayeda A
    The14th International Congress of Endocrinology, 26 Apr. 2010
  • The mechanism of aberrant exon-skipping mediated by atypical U1 snRNP-HMGA1a complex.
    Ohe K; Manabe T; Mayeda A
    RNA 2008 (Thirteenth Annual Meeting of the RNA society, 2008
  • HMGA1a is a potential exon skipping factor.
    Ohe K; Manabe T; Katayama T; Tohyama M; Reeves R; Mayeda A
    EUKARYOTIC mRNA PROCESSING meeting 2003 (Cold Spring Harbor Laboratory meeting), 2003
  • Interferon-γ suppresses thyrotropin receptor promoter activity by reducing thyroid transcription factor-1 (TTF-1) binding to its recognition site.
    Ohe K; Ikuyama S; Takayanagi R; Kohn LD; Nawata H
    11th International Thyroid Congress, 1995
■ Affiliated academic society
  • 日本分子生物学会
  • 日本内科学会
  • 日本糖尿病学会
  • 日本ステロイド学会
  • 日本甲状腺学会
  • 日本内分泌学会
  • 日本RNA学会
■ Research Themes
  • CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製
    基礎研究S
    2015 - 2019
  • スプライシング操作化合物を対象としたファーマコゲノミクス解析に基づく遺伝性難病治療薬の開発研究
    国立研究開発法人日本医療研究開発機構 ゲノム医療実用化推進研究事業
    2016 - 2017
  • 遺伝性乳癌のスプライシング改変による新たな治療法をめざす
    文部科学省, 科学研究費補助金(基盤研究(C)), 基盤研究(C)
    2015 - 2017
  • 短鎖RNAによるホルモン治療抵抗性乳癌の新たな治療法の開発
    文部科学省, 科学研究費補助金(基盤研究(C))
    2012 - 2014
  • HMGA1の新規機能によるエストロゲン受容体の発現制御ー新たな乳癌治療をめざすー
    文部科学省, 科学研究費補助金(基盤研究(C)), 基盤研究(C)
    2009 - 2011
  • 可溶性因子による副腎再生の試み
    文部科学省, 科学研究費補助金(基盤研究(C)), 基盤研究(C)
    2006 - 2008
  • 性分化に及ぼす性ステロイド合成・作用系異常に関する基礎的、臨床的研究
    文部科学省, 科学研究費補助金(特定領域研究), 特定領域研究
    2004 - 2008
  • アンドロゲン非依存性前立腺癌の治療標的アクチビン・ヘッジホッグシグナルの機能解析
    文部科学省, 科学研究費補助金(基盤研究(C)), 基盤研究(C)
    2006 - 2007
  • アンドロゲンとその標的因子による中枢性肥満と動脈硬化の制御の分子メカニズム
    文部科学省, 科学研究費補助金(基盤研究(S)), 基盤研究(S)
    2005 - 2007