Mar. 2021
下田光造記念賞

Sep. 2020
優秀ポスター賞
サポートベクターマシンを用いた顕微鏡下凝集試験（MAT）の自動化

Unification of symbiotic bacteria during larva-to-adult transition in Culicoides circumscriptus (Diptera: Ceratopogonidae)
Ryo Ozuru; Junya Yamagishi; Ayumi Takeuchi; Yusuke Date; Takatoshi Fujii; Chihiro Sugimoto; Chie Nakajima; Yasuhiko Suzuki; Kaoru Aoki; Jun Fujii; Takashi Matsuba
FEMS Microbiology Letters, 03 Jul. 2025, 372, Refereed
Lead

Objectification of evaluation criteria in microscopic agglutination test using deep learning.
Risa Nakano; Yuji Oyamada; Ryo Ozuru; Michinobu Yoshimura; Kenji Hiromatsu
Journal of microbiological methods, Jul. 2024, 222:106955 - 106955, Refereed
Corresponding

A machine learning model of microscopic agglutination test for diagnosis of leptospirosis
Yuji Oyamada; Ryo Ozuru; Toshiyuki Masuzawa; Satoshi Miyahara; Yasuhiko Nikaido; Fumiko Obata; Mitsumasa Saito; Sharon Yvette Angelina M. Villanueva; Jun Fujii
PLOS ONE, 16 Nov. 2021, 16(11):e0259907 - e0259907, Refereed
Lead

Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice.
Ryo Ozuru; Shohei Wakao; Takahiro Tsuji; Naoya Ohara; Takashi Matsuba; Muhammad Y Amuran; Junko Isobe; Morio Iino; Naoki Nishida; Sari Matsumoto; Kimiharu Iwadate; Noriko Konishi; Kaori Yasuda; Kosuke Tashiro; Misato Hida; Arisato Yadoiwa; Shinsuke Kato; Eijiro Yamashita; Sohkichi Matsumoto; Yoichi Kurozawa; Mari Dezawa; Jun Fujii
Molecular therapy : the journal of the American Society of Gene Therapy, 08 Jan. 2020, 28(1):100 - 118, Refereed
Lead

Synthesis of a Cleaved Form of Osteopontin by THP-1 Cells and Its Alteration by Phorbol 12-Myristate 13-Acetate and BCG Infection
Gaowa Bai; Hirotoshi Motoda; Ryo Ozuru; Haorile Chagan-Yasutan; Toshio Hattori; Takashi Matsuba
International Journal of Molecular Sciences, 31 Jan. 2018, 19(2):418 - 418, Refereed
Lead

Adipose tissue is the first colonization site of Leptospira interrogans in subcutaneously infected hamsters
Ryo Ozuru; Mitsumasa Saito; Takaaki Kanemaru; Satoshi Miyahara; Sharon Y. A. M. Villanueva; Gerald L. Murray; Ben Adler; Jun Fujii; Shin-ichi Yoshida
PLOS ONE, Feb. 2017, 12(2):e0172973, Refereed
Lead

Mycobacterium abscessus resides within lipid droplets and acquires a dormancy-like phenotype in adipocytes.
Yusuke Kurihara; Akinori Shimizu; Ryo Ozuru; Michinobu Yoshimura; Bin Chou; Ryota Itoh; Kazunari Ishii; Yuko Hirota; Satoshi Takagi; Masaki Fujita; Masahiro Inoue; Kenji Hiromatsu
Biochemical and biophysical research communications, 14 Mar. 2025, 758:151645 - 151645

Insufficient anti-spike RBD IgA responses after triple vaccination with intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2
Michinobu Yoshimura; Atsuhiko Sakamoto; Ryo Ozuru; Yusuke Kurihara; Ryota Itoh; Kazunari Ishii; Akinori Shimizu; Bin Chou; Yusuke Sechi; Aya Fujikane; Shigeki Nabeshima; Kenji Hiromatsu
Heliyon, Jan. 2024, Refereed

The appearance of anti-spike RBD IgG4 responses after repetitive immunization with mRNA-based COVID-19 vaccines.
Michinobu Yoshimura; Atsuhiko Sakamoto; Ryo Ozuru; Yusuke Kurihara; Ryota Itoh; Kazunari Ishii; Akinori Shimizu; Bin Chou; Shigeki Nabeshima; Kenji Hiromatsu
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 27 Nov. 2023, Refereed

Chlamydia pneumoniae Lung Infection in Mice Induces Fatty Acid-Binding Protein 4-Dependent White Adipose Tissue Pathology.
Yusuke Kurihara; Nirwana Fitriani Walenna; Kazunari Ishii; Toshinori Soejima; Bin Chou; Michinobu Yoshimura; Ryo Ozuru; Akinori Shimizu; Ryota Itoh; Masato Furuhashi; Gökhan S Hotamisligil; Kenji Hiromatsu
Journal of immunology (Baltimore, Md. : 1950), 15 Apr. 2023, 210(8):1086 - 1097, Refereed

Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan
Atsuhiko Sakamoto; Michinobu Yoshimura; Ryota Itoh; Ryo Ozuru; Kazunari Ishii; Yusuke Sechi; Shigeki Nabeshima; Kenji Hiromatsu
Vaccines, May 2022, 10(6), Refereed

Light dependent synthesis of a nucleotide second messenger controls the motility of a spirochete bacterium.
Jun Xu; Nobuo Koizumi; Yusuke V Morimoto; Ryo Ozuru; Toshiyuki Masuzawa; Shuichi Nakamura
Scientific reports, 26 Apr. 2022, 12(1):6825 - 6825, Refereed

Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule
Fumiko Obata; Ryo Ozuru; Takahiro Tsuji; Takashi Matsuba; Jun Fujii
Toxins, 19 Jan. 2022, 14(2):69 - 69, Refereed

Investigation of Bacteria from Spoiled Bottled Salad Dressing Leading to Gas Explosion
Fumiko Obata; Hiromi Murota; Satoshi Shibata; Ryo Ozuru; Jun Fujii
Yonago Acta Medica, 2022, 65(3):207 - 214

Inhibition of inflammatory-molecule synthesis in THP-1 cells stimulated with phorbol 12-myristate 13-acetate by brefelamide derivatives
Gaowa Bai; Takashi Matsuba; Haruhisa Kikuchi; Haorile Chagan-Yasutan; Hirotoshi Motoda; Ryo Ozuru; Osamu Yamada; Yoshiteru Oshima; Toshio Hattori
International Immunopharmacology, Oct. 2019, 75:105831 - 105831, Refereed

The usefulness of semi-solid medium in the isolation of highly virulent Leptospira strains from wild rats in an urban area of Fukuoka, Japan
Mitsumasa Saito; Sharon Y. A. M. Villanueva; Toshiyuki Masuzawa; Yusuke Haraguchi; Shuhei Ita; Satoshi Miyahara; Ryo Ozuru; Takayoshi Yamaguchi; Michinobu Yoshimura; Mami Ikejiri; Natsumi Aramaki; Muhammad Yunus Amran; Lisa Tenriesa Muslich; Ken-ichiro Iida; Yasutake Yanagihara; Nina G. Gloriani; Shin-ichi Yoshida
MICROBIOLOGY AND IMMUNOLOGY, Jun. 2015, 59(6):322 - 330, Refereed

Comparative Analysis of Leptospira Strains Isolated from Environmental Soil and Water in the Philippines and Japan
Mitsumasa Saito; Sharon Y. A. M. Villanueva; Antara Chakraborty; Satoshi Miyahara; Takaya Segawa; Tatsuma Asoh; Ryo Ozuru; Nina G. Gloriani; Yasutake Yanagihara; Shin-ichi Yoshida
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Jan. 2013, 79(2):601 - 609, Refereed

光活性型アデニル酸シクラーゼによるレプトスピラ・コバヤシイの運動活性化
許駿; 小泉信夫; 森本雄祐; 尾鶴亮; 増澤俊幸; 中村修一
レプトスピラ・シンポジウム抄録(CD-ROM), 2022, 58th

SARS-CoV-2 m-RNAワクチン(BNT162b)の2回接種・3回接種による抗体の獲得状況とブレイクスルー感染に関する研究
坂本篤彦; 坂本篤彦; 坂本篤彦; 吉村芳修; 伊藤竜太; 石井一成; 尾鶴亮; 栗原悠介; 瀬知裕介; 藤兼亜耶; 廣松賢治; 鍋島茂樹
日本ウイルス学会学術集会プログラム・予稿集(Web), 2022, 69th

細菌検査を自動化する レプトスピラ症の顕微鏡下凝集試験(Microscopic Agglutination Test;MAT)を例に
尾鶴 亮; 小山田 雄仁; 増澤 俊之; 宮原 敏; 二階堂 靖彦; 齋藤 光正; Villanueva Sharon Y.A.M.; 藤井 潤
日本細菌学雑誌, Feb. 2021, 76(1):89 - 89

免疫不全マウスを用いた新たな劇症型溶血性レンサ球菌感染症マウスモデルの開発(Establishment of a new Streptococcal toxic shock syndrome model using immunocompromised mice)
辻 高寛; 小幡 史子; 尾鶴 亮; 宮原 敏; 齋藤 光正; 藤井 潤
日本細菌学雑誌, Feb. 2021, 76(1):108 - 108

四半世紀に及んだ腸管出血性大腸菌感染症の戦いと未来 感染症ミューズ細胞治療の挑戦(Quarter century battle against EHEC infectious disease; Muse cell therapy challenge on infectious diseases)
藤井 潤; 出澤 真理; 尾鶴 亮; 若尾 昌平; 辻 高寛; 松葉 隆司; 黒沢 洋一; 大原 直也; 松本 壮吉; 安田 香央里; 飯野 守男
日本細菌学雑誌, Feb. 2021, 76(1):126 - 126

細菌検査を自動化する レプトスピラ症の顕微鏡下凝集試験(Microscopic Agglutination Test;MAT)を例に
尾鶴 亮; 小山田 雄仁; 増澤 俊之; 宮原 敏; 二階堂 靖彦; 齋藤 光正; Villanueva Sharon Y.A.M.; 藤井 潤
日本細菌学雑誌, Feb. 2021, 76(1):89 - 89

免疫不全マウスを用いた新たな劇症型溶血性レンサ球菌感染症マウスモデルの開発(Establishment of a new Streptococcal toxic shock syndrome model using immunocompromised mice)
辻 高寛; 小幡 史子; 尾鶴 亮; 宮原 敏; 齋藤 光正; 藤井 潤
日本細菌学雑誌, Feb. 2021, 76(1):108 - 108

2016年、キュウリを原因とした腸管出血性大腸菌O157の集団感染
尾鶴 亮; 立石 善隆; 小西 典子; 松本 壮吉; 松葉 隆司; 藤井 潤
日本細菌学雑誌, Feb. 2018, 73(1):68 - 68

2016年、キュウリを原因とした腸管出血性大腸菌O157の集団感染
尾鶴 亮; 立石 善隆; 小西 典子; 松本 壮吉; 松葉 隆司; 藤井 潤
日本細菌学雑誌, Feb. 2018, 73(1):68 - 68

腸管出血性大腸菌感染マウスモデルおける再生医療(Muse細胞)を用いた急性脳症の治療効果(Effects of Muse cells on acute encephalopathy caused by Shiga toxin-producing E. coil infection in mice)
尾鶴 亮; 若尾 昌平; 松葉 隆司; 磯部 順子; 木全 恵子; 綿引 正則; 出澤 真理; 藤井 潤
日本細菌学雑誌, Feb. 2017, 72(1):158 - 158

半固形コルトフ培地を用いた福岡都心部の野生ラットからの病原性レプトスピラ分離と分離株の解析(The usefulness of semi-solid medium in the isolation of Leptospira strains from wild rats in Fukuoka)
齋藤 光正; Villanueva Sharon Yvette Angelina; 増澤 俊幸; 宮原 敏; 尾鶴 亮; 山口 孝治; 吉村 芳修; 池尻 真美; 荒牧 夏美; 飯田 健一郎; 柳原 保武; 吉田 眞一
日本細菌学雑誌, Feb. 2015, 70(1):210 - 210

フィリピンで流行している五つのレプトスピラの血清型に対するワクチンの開発と評価(Development and evaluation of vaccines against 5 leptospiral serovars prevailing in the Philippines)
Villanueva Sharon Yvette Angelina; 柳原 保武; 齋藤 光正; 瀬川 孝耶; 尾鶴 亮; 池尻 真美; Gloriani Nina; 吉田 眞一
日本細菌学雑誌, Feb. 2015, 70(1):236 - 236

Advancing Leptospirosis Research Through Responsible Animal Experimentation: Leveraging In Vivo Imaging and Omics Data Reanalysis
Ryo Ozuru
34th PALAS Annual Scientific Conference, 08 Aug. 2025

さまざまな環境を移行する 病原性スピロヘータの形態と代謝
尾鶴亮; 今園泰隆; 園田卓己; 吉村芳修; 小幡史子; 佐藤主税; 佐藤真理; Jason A. Papin; Glynis L. Kolling; 廣松賢治
日本顕微鏡学会 第81回学術講演会, 11 Jun. 2025

Leptospirosis: Why Is Diagnosis So Difficult and How Can We Improve It?
Ryo Ozuru
The 1st International Online Conference on Clinical Reports, 20 Mar. 2025

Automating tests for leptospirosis with deep learning -Seeing "by computer" is believing-
Ryo Ozuru
Philippine Society for Microbiology Cluster 1 Symposium: “Computational Microbiology and Biotechnology in an Evolving Microbial World”, 23 Jan. 2024

Seeing is believing: Making Agglutination Tests from Qualitative to Quantitative with Deep Learning
尾鶴 亮; 中野 里咲; 小山田 雄仁; 宮原 敏; 吉村 芳修; 廣松 賢治
第96回日本細菌学会総会, 18 Mar. 2023

凝集反応検査を自動化する-レプトスピラ症における顕微鏡下凝集試験の深層学習判定モデルを基に-
尾鶴亮; 中野里咲; 小山田雄仁
第95回日本細菌学会総会, 29 Mar. 2022

若手から見た異分野融合とその難しさ〜現場の声〜 2. 細菌学的に見た再生医療との異分野融合
尾鶴 亮; 藤井 潤
第94回日本細菌学会総会, 24 Mar. 2021

レプトスピラの病原性と菌体回転運動の関わり
尾鶴亮
第171回バイオメカニクス研究会, 16 Nov. 2018

Pangenome-scale metabolic modeling reveals pathogenicity-specific pathways in zoonotic spirochetes
Takumi Sonoda; Ryo Ozuru; Michinobu Yoshimura; Jason A. Papin; Fumiko Obata; Glynis L. Kolling; Kenji Hiromatsu
The 25th International Conference on Emerging Infectious Diseases in the Pacific Rim, 15 Mar. 2025

Objectification of Evaluation Criteria In Leptospirosis Testing Using Deep Learning
Risa Nakano; Yuji Oyamada; Ryo Ozuru
The 13th Conference of the International Leptospirosis Society, 04 Sep. 2024

Pathogenic leptospires induce lipolysis in host adipocytes via adrenergic receptors to obtain their carbon sources.
Ryo Ozuru; Kazunari Ishii; Shotaro Fujiki; Kenji Hiromatsu
The 21st Awaji International Forum on Infection and Immunity, 05 Sep. 2023

PATHOGENIC LEPTOSPIRES INDUCE LIPOLYSIS IN HOST ADIPOCYTES TO OBTAIN THEIR CARBON SOURCES.
Ryo Ozuru; Michinobu Yoshimura; Yusuke Kurihara; Kazunari Ishii; Kenji Hiromatsu
12th International Leptospirosis Society Conference 2022, 14 Nov. 2022

Effects of Multilineage-differentiating stress-enduring (Muse) cells on brain damage induced by Shiga toxin 2 (Stx2) in vivo and in vitro
Ryo Ozuru; Wakao Shohei; Mari Dezawa; Jun Fujii
21st International Conference On Emerging Infectious Diseases In The Pacific Rim, 2019

Therapeutic effects of Multilineage-differentiating stress-enduring (Muse) cells as stem cells on encephalopathy caused by Shiga toxin-producing Escherichia oral infection
Ryo Ozuru; Wakao Shohei; Muhammad Yunus Amuran; Kazumasa Kuroda; Matsuba Takashi; Taniguchi Naomi; Mari Dezawa; Jun Fujii
10th International Symposium on Shiga Toxin Producing E. coli Infections, 2018

Adipose tissue is the first colonization site of Leptospira interrogans in subcutaneously infected hamsters.
Ryo Ozuru; Mitsumasa Saito; Takaaki Kanemaru; Satoshi Miyahara; Sharon Y.A.M. Villanueva; Gerald L. Murray; Ben Adler; Jun Fujii; Shin-ichi Yoshida
10th International Leptospirosis Society Conference 2017, 01 Dec. 2017

New insights into the leptospiral dissemination in host bodies brought by in vivo imaging system
Ryo Ozuru; Mitsumasa Saito; Takaaki Kanemaru; Satoshi Miyahara; Sharon Y.A.M. Villanueva; Gerald L. Murray; Ben Adler; Jun Fujii; Shin-ichi Yoshida
The 15th Awaji International Forum on Infection and Immunity, 08 Sep. 2015

Microbiology
Apr. 2021 - Present
Fukuoka University

基礎感染症学実習
Apr. 2015 - Mar. 2021
鳥取大学

Basic Infectious Diseases
Apr. 2016 - 2021
Tottori University

Jan. 2020 - Present
The Japanese Society for Bioinformatics

Feb. 2013 - Present
JAPANESE SOCIETY FOR BACTERIOLOGY

日本レプトスピラ研究会

成人T細胞性白血病の病態解明のための腸内細菌の解析
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
Apr. 2025 - Mar. 2029

重症化抑制への応用を目指したレプトスピラ由来宿主脂肪分解因子の同定と機能解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2024 - 31 Mar. 2027

レプトスピラの脂肪組織定着機構を利用したレプトスピラ症新規バイオマーカーの創出
日本学術振興会, 科学研究費助成事業 若手研究, 若手研究
鳥取大学
01 Apr. 2021 - 31 Mar. 2024

レプトスピラが宿主の脂肪組織血管内に定着する分子機構の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists
Tottori University
Apr. 2018 - Mar. 2021

レプトスピラ症の感染成立から重症化に至るまでのメカニズムの解明と予防方法の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Apr. 2013 - Mar. 2016