Inhibitory Effect of Pyra-Metho-Carnil on the Differentiation and Maturation of Macrophages in Normal and Cancer Microenvironments.
Takanori Kitaguchi; Taichi Matsumoto; Kazumasa Yoshida; Yuriko Hamaguchi; Gen Maruta; Hisanori Maeoka; Shuhei Ishikura; Michitaka Nakano; Yusuke Ishida; Fumihito Hirai; Mikiko Aoki; Shohta Kodama; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2024, 44(8):3557 - 3565, Refereed

Inhibitory Effect of Pyra–Metho–Carnil on Cancer Spheroid Growth Through Decrease in Glycolysis-associated Molecules
KAZUMASA YOSHIDA; KENSUKE NISHI; SHUHEI ISHIKURA; TAICHI MATSUMOTO; KAZUHIKO NAKABAYASHI; RYO YAZAKI; TAKASHI OHSHIMA; MASAHIKO SUENAGA; SENJI SHIRASAWA; TOSHIYUKI TSUNODA
Anticancer Research, 26 Jul. 2023, 43(8):3717 - 3726, Refereed
Lead

Death domain-associated protein DAXX regulates non-coding RNA transcription at the centromere through the transcription regulator ZFAT.
Shuhei Ishikura; Kazumasa Yoshida; Toshiyuki Tsunoda; Senji Shirasawa
The Journal of biological chemistry, 23 Sep. 2022, 298(11):102528 - 102528, Refereed

Microscopic Detection of DNA Synthesis in Early Mitosis at Repetitive lacO Sequences in Human Cells.
Kazumasa Yoshida; Riko Ishimoto; Masatoshi Fujita
Bio-protocol, 05 Sep. 2022, 12(17)
Lead

Cancer Spheroid Proliferation Is Suppressed by a Novel Low-toxicity Compound, Pyra-Metho-Carnil, in a Context-independent Manner.
Kazumasa Yoshida; Kensuke Nishi; Shuhei Ishikura; Kazuhiko Nakabayashi; Ryo Yazaki; Takashi Ohshima; Masahiko Suenaga; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2022, 42(8):3993 - 4001, Refereed
Lead

TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress.
Mitsunori Higa; Yukihiro Matsuda; Jumpei Fujii; Nozomi Sugimoto; Kazumasa Yoshida; Masatoshi Fujita
Nucleic acids research, 02 Dec. 2021, 49(21):12234 - 12251, Refereed
Corresponding

CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA
Shuhei Ishikura; Kazumasa Yoshida; Sayuri Hashimoto; Kazuhiko Nakabayashi; Toshiyuki Tsunoda; Senji Shirasawa
Journal of Biological Chemistry, Oct. 2021, 297(4):101213 - 101213, Refereed

SLX4–XPF mediates DNA damage responses to replication stress induced by DNA–protein interactions
Riko Ishimoto; Yota Tsuzuki; Tomoki Matsumura; Seiichiro Kurashige; Kouki Enokitani; Koki Narimatsu; Mitsunori Higa; Nozomi Sugimoto; Kazumasa Yoshida; Masatoshi Fujita
Journal of Cell Biology, 04 Jan. 2021, 220(1):e202003148, Refereed
Corresponding

Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10.
Yokoyama T; Yukuhiro M; Iwasaki Y; Tanaka C; Sankoda K; Fujiwara R; Shibuta A; Higashi T; Motoyama K; Arima H; Yoshida K; Sugimoto N; Morimoto H; Kosako H; Ohshima T; Fujita M
Scientific reports, Nov. 2019, 9(1):16825 - 16825, Refereed

GRWD1 directly interacts with p53 and negatively regulates p53 transcriptional activity.
Fujiyama H; Tsuji T; Hironaka K; Yoshida K; Sugimoto N; Fujita M
Journal of biochemistry, Sep. 2019, 167:15 - 24, Refereed

Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib.
Morii I; Iwabuchi Y; Mori S; Suekuni M; Natsume T; Yoshida K; Sugimoto N; Kanemaki MT; Fujita M
Cancer science, Mar. 2019, 110(3):1044 - 1053, Refereed

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system
Watanabe Shinya; Fujiyama Hiroki; Takafuji Takuya; Kayama Kota; Matsumoto Masaki; Nakayama Keiichi I; Yoshida Kazumasa; Sugimoto Nozomi; Fujita Masatoshi
JOURNAL OF CELL SCIENCE, Aug. 2018, 131(15), Refereed

Genome-wide analysis of the spatiotemporal regulation of firing and dormant replication origins in human cells
Sugimoto Nozomi; Maehara Kazumitsu; Yoshida Kazumasa; Ohkawa Yasuyuki; Fujita Masatoshi
NUCLEIC ACIDS RESEARCH, 27 Jul. 2018, 46(13):6683 - 6696, Refereed

TRF2 recruits ORC through TRFH domain dimerization
Mitsunori Higa; Tatsunori Kushiyama; Seiichiro Kurashige; Daisuke Kohmon; Kouki Enokitani; Satoko Iwahori; Nozomi Sugimoto; Kazumasa Yoshida; Masatoshi Fujita
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Jan. 2017, 1864(1):191 - 201, Refereed
Corresponding

GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis
Kota Kayama; Shinya Watanabe; Takuya Takafuji; Takahiro Tsuji; Kensuke Hironaka; Masaki Matsumoto; Keiichi I. Nakayama; Masato Enari; Takashi Kohno; Kouya Shiraishi; Tohru Kiyono; Kazumasa Yoshida; Nozomi Sugimoto; Masatoshi Fujita
EMBO REPORTS, Jan. 2017, 18(1):123 - 137, Refereed

Nucleosome assembly and disassembly activity of GRWD1, a novel Cdt1-binding protein that promotes pre-replication complex formation
Masahiro Aizawa; Nozomi Sugimoto; Shinya Watanabe; Kazumasa Yoshida; Masatoshi Fujita
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Nov. 2016, 1863(11):2739 - 2748, Refereed

A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo
Makoto Ohira; Yuka Iwasaki; Chika Tanaka; Michitaka Kuroki; Naoki Matsuo; Tatsuhiko Kitamura; Masaki Yukuhiro; Hiroyuki Morimoto; Nisha Pang; Bei Liu; Tohru Kiyono; Masahide Amemiya; Kozo Tanaka; Kazumasa Yoshida; Nozomi Sugimoto; Takashi Ohshima; Masatoshi Fujita
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Sep. 2015, 1850(9):1676 - 1684, Refereed

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture
Nozomi Sugimoto; Kazumitsu Maehara; Kazumasa Yoshida; Shuhei Yasukouchi; Satoko Osano; Shinya Watanabe; Masahiro Aizawa; Takashi Yugawa; Tohru Kiyono; Hitoshi Kurumizaka; Yasuyuki Ohkawa; Masatoshi Fujita
NUCLEIC ACIDS RESEARCH, Jul. 2015, 43(12):5898 - 5911, Refereed

The Histone Deacetylases Sir2 and Rpd3 Act on Ribosomal DNA to Control the Replication Program in Budding Yeast
Kazumasa Yoshida; Julien Bacal; Damien Desmarais; Ismael Padioleau; Olga Tsaponina; Andrei Chabes; Veronique Pantesco; Emeric Dubois; Hugues Parrinello; Magdalena Skrzypczak; Krzysztof Ginalski; Armelle Lengronne; Philippe Pasero
MOLECULAR CELL, May 2014, 54(4):691 - 697, Refereed
Lead

Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing
Julien N. Bianco; Jerome Poli; Julie Saksouk; Julien Bacal; Maria Joao Silva; Kazumasa Yoshida; Yea-Lih Lin; Helene Tourriere; Armelle Lengronne; Philippe Pasero
METHODS, Jun. 2012, 57(2):149 - 157, Refereed

CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells
Kazumasa Yoshida; Nozomi Sugimoto; Satoko Iwahori; Takashi Yugawa; Mako Narisawa-Saito; Tohru Kiyono; Masatoshi Fujita
JOURNAL OF CELL SCIENCE, Jan. 2010, 123(2):225 - 235, Refereed
Lead

Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells
Nozomi Sugimoto; Kazumasa Yoshida; Yasutoshi Tatsumi; Takashi Yugawa; Mako Narisawa-Saito; Shou Waga; Tohru Kiyono; Masatoshi Fujita
JOURNAL OF CELL SCIENCE, Apr. 2009, 122(8):1184 - 1191, Refereed

Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres
Yasutoshi Tatsumi; Kai Ezura; Kazumasa Yoshida; Takashi Yugawa; Mako Narisawa-Saito; Tohru Kiyono; Satoshi Ohta; Chikashi Obuse; Masatoshi Fujita
GENES TO CELLS, Oct. 2008, 13(10):1045 - 1059, Refereed

Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs
K Yoshida; H Takisawa; Y Kubota
GENES TO CELLS, Jan. 2005, 10(1):63 - 74, Refereed
Lead

DNA damage responses that enhance resilience to replication stress
Kazumasa Yoshida; Masatoshi Fujita
Cellular and Molecular Life Sciences, 31 Aug. 2021, Refereed
Lead

DNA Replication Origins and Fork Progression at Mammalian Telomeres
Mitsunori Higa; Masatoshi Fujita; Kazumasa Yoshida
GENES, Apr. 2017, 8(4), Refereed
Last

The replication timing program in the hands of two HDACs.
Yoshida K; Lengronne A; Pasero P
Microbial cell (Graz, Austria), Jul. 2014, 1(8):273 - 275, Refereed
Lead

出芽酵母においてヒストン脱アセチル化酵素はリボソームDNA領域におけるクロマチンの制御を介して複製のタイミングを制御している
吉田 和真
ライフサイエンス 新着論文レビュー, May 2014, 8926
Lead

Time to Be Versatile: Regulation of the Replication Timing Program in Budding Yeast
Kazumasa Yoshida; Ana Poveda; Philippe Pasero
JOURNAL OF MOLECULAR BIOLOGY, Nov. 2013, 425(23):4696 - 4705, Refereed
Lead

Genetic and epigenetic determinants of DNA replication origins, position and activation
Mechali Marcel; Yoshida Kazumasa; Coulombe Philippe; Pasero Philippe
CURRENT OPINION IN GENETICS & DEVELOPMENT, Apr. 2013, 23(2):124 - 131, Refereed

第2章 S期―ここまでわかったDNA複製とその制御 4.DNA複製のライセンス化制御
吉田和真; 滝沢温彦; 久保田弓子
実験医学, 20 May 2005, 23(9):1340 - 1346

ポリメラーゼとヘリカーゼの解離を伴わない複製ストレスに対するDNAダメージ応答
藤田雅俊; 杉本のぞみ; 吉田和真
第44回日本分子生物学会年会, 01 Dec. 2021

TRF2‐ORC結合およびテロメア内複製開始点の重要性の解析
比嘉允宣; 松田侑大; 杉本のぞみ; 吉田和真; 藤田雅俊
日本薬学会九州支部大会, 05 Nov. 2018

ヒト染色体上の“複製が困難な領域“における複製フォーク異常停止によって誘導されるDNA損傷応答と染色体異常のlacO‐LacIシステムを利用した解析
石本理子; 都築洋太; 杉本のぞみ; 吉田和真; 藤田雅俊
第４１回日本分子生物学会年会, Nov. 2018

リピート配列におけるDNA‐タンパク質複合体がヒト染色体上で誘導する複製ストレス応答の解析
吉田和真; 石本理子; 都築洋太; 松村友輝; 比嘉允宣; 松田侑大; 杉本のぞみ; 藤田雅俊
日本分子生物学会年会プログラム・要旨集(Web), Nov. 2018

lacO‐LacIがヒト染色体において誘導するDNA損傷応答経路の解析
吉田和真; 都築洋太; 串山辰徳; 石本理子; 杉本のぞみ; 藤田雅俊
第４０回日本分子生物学会年会(Web), Dec. 2017

ヒト染色体上のlac0‐LacI複合体が誘導するDNA損傷応答へのHP1タンパク質の寄与の解明
串山辰徳; 都築洋太; 石本理子; 杉本のぞみ; 吉田和真; 藤田雅俊
日本薬学会九州支部大会講演要旨集, 10 Nov. 2017

lacO-LacI結合がヒト染色体において誘導する複製ストレス応答の解析
吉田 和真; 都築洋太; 串山辰徳; 石本理子; 杉本 のぞみ; 藤田 雅俊
第２４回DNA複製・組換え・修復ワークショップ, Nov. 2017

TRF2は二量体TRFHドメインを介してORCをリクルートする
吉田和真; 比嘉允宣; 杉本のぞみ; 藤田雅俊
第39回日本分子生物学会年会プログラム・要旨集(Web), Dec. 2016

TRF2はTRFHドメインの二量体化を介してORCをリクルートする
吉田 和真; 比嘉 允宣; 倉重 誠一郎; 向門 大介; 榎谷 光熙; 杉本 のぞみ; 藤田 雅俊
第２３回DNA複製・組換え・修復ワークショップ, Oct. 2015

クロマチン制御とDNA複製開始制御の連携
吉田和真; 杉本のぞみ; 藤田雅俊
日本薬学会第135年会要旨集(CD-ROM), Mar. 2015

Sir2およびRpd3はリボソームDNA複製活性調節を介して出芽酵母のゲノム複製タイミングを制御している
吉田和真; 藤田雅俊; PASERO Philippe
第３６回日本分子生物学会年会プログラム・要旨集(Web), Dec. 2013

The HDACs Rpd3 and Sir2 control replication timing in budding yeast by regulating the activity of rDNA origins
Kazumasa YOSHIDA; Damien DESMARAIS; Armelle LENGRONNE, Philippe PASERO
The CSHL meeting on EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE, Sep. 2013

Regulation of DNA replication timing by histone deacetylases in S. cerevisiae
YOSHIDA Kazumasa
The 8th 3R Symposium, 25 Nov. 2012

Regulation of DNA replication timing by histone deacetylases in S.cerevisiae
YOSHIDA Kazumasa
The 5th EMBO YIP sectoral meeting “Genomic Instability”, 15 Nov. 2012

Genome-wide study of histone deacetylases as key regulators of DNA replication timing in budding yeast.
YOSHIDA Kazumasa
Chromatin Meets South -2nd Meeting on Chromatin from Southern France-, Jun. 2012

出芽酵母染色体におけるヒストン脱アセチル化酵素(HDAC)によるDNA複製開始の時間的制御機構
YOSHIDA Kazumasa
第34回 日本分子生物学会年会, Dec. 2011

Regulation of replication timing by histone deacetylases
YOSHIDA Kazumasa
2011 EMBO YIPs workshop “DNA repair and DNA replication”, 03 Nov. 2011

Genome-wide study of histone deacetylases as key regulators of the temporal program of origin activation in budding yeast
YOSHIDA Kazumasa
The 7th 3R Symposium, Oct. 2010

CDC6 Interaction with ATR Regulates Activation of a Replication Checkpoint in Higher Eukaryotic Cells
YOSHIDA Kazumasa
第32回 日本分子生物学会年会, Dec. 2009

CDC6 Interaction with ATR Regulates Activation of a Replication Checkpoint in Higher Eukaryotic Cells
YOSHIDA Kazumasa
Keystone Symposia “Telomere Biology and DNA Repair”, Oct. 2009

CDC6はATRキナーゼと結合し複製チェックポイント活性化を制御している
YOSHIDA Kazumasa
第68回 日本癌学会学術総会, Oct. 2009

Cdc6はCdkリン酸化依存的にATRと相互作用することにより複製チェックポイント活性化を制御している
吉田和真; 清野透; 藤田雅俊
第31回 日本分子生物学会年会, Dec. 2008

CDK phosphorylation-dependent CDC6 interaction with ATR regulates activation of replication checkpoint in higher eukaryotic cells
YOSHIDA Kazumasa
The 6th 3R Symposium, Oct. 2008

CDKリン酸化依存的なCDC6とATM/ATRの相互作用はG2/Mチェックポイント活性化に関与する
YOSHIDA Kazumasa
第67回日本癌学会学術総会, Oct. 2008

CDK Phosphorylation-dependent Interaction of Human Cdc6 with ATR is involved in G2/M Checkpoint Response
YOSHIDA Kazumasa
DNA Replication & Genome Integrity, Jul. 2008

ヒトCdc6とATM/ATRチェックポイントキナーゼのCDKリン酸化依存性相互作用
吉田和真; 清野透; 藤田雅俊
第30回日本分子生物学会年会, Dec. 2007

CDK PHOSPHORYLATION-DEPENDENT INTERACTION OF HUMAN CDC6 WITH ATM/ATR CHECKPOINT KINASES
YOSHIDA Kazumasa
Cold Spring Harbor Meeting “Eukaryotic DNA Replication & Genome Maintenance”, Sep. 2007

アフリカツメガエルCdt1によるDNA複製チェックポイントの活性化
吉田和真; 久保田弓子; 滝沢温彦
第28回日本分子生物学会年会, 07 Dec. 2005

Xenopus Cdt1 activates replication checkpoint in the absence of re-replication of DNA
YOSHIDA Kazumasa
Cold Spring Harbor Meeting “Eukaryotic DNA Replication”, 07 Sep. 2005

アフリカツメガエルgemininによるDNA複製のライセンス化制御
吉田和真; 久保田弓子; 滝沢温彦
第27回日本分子生物学会年会プログラム・講演要旨集, 08 Dec. 2004

A ROLR OF XENOPUS GEMININ IN THE LICENSING OF DNA REPLICATION
YOSHIDA Kazumasa
Cold Spring Harbor Meeting “The Cell Cycle”, May 2004

アフリカツメガエルgemininによるDNA複製のライセンス化制御
吉田和真; 久保田弓子; 滝沢温彦
第26回日本分子生物学会年会プログラム・講演要旨集, 10 Dec. 2003

複製のライセンス化阻害因子gemininの核移行シグナル
吉田和真; 久保田弓子; 滝澤温彦
第56回 日本細胞生物学会大会講演要旨集, May 2003

複製開始ライセンス化阻害因子gemininの核移行機構の解析
YOSHIDA Kazumasa
第25回 日本分子生物学会年会, 11 Dec. 2002

複製開始ライセンス化阻害因子gemininの核移行制御の解析
吉田和真; 久保田弓子; 滝澤温彦
第55回 日本細胞生物学会大会講演要旨集, May 2002

THE PHARMACEUTICAL SOCIETY OF JAPAN

THE JAPANESE CANCER ASSOCIATION

日本分子生物学会

新規抗腫瘍薬で探る変異KRAS陽性癌細胞の小胞体ストレス応答と細胞死誘導制御
日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
福岡大学
01 Apr. 2022 - 31 Mar. 2025

TRF2依存性ORCリクルートによるテロメア維持機構の特異的変異体創出による解明
文部科学省, 科学研究費補助金 若手研究(B)
Apr. 2017 - Mar. 2019

ATR-CDC6系を介した内因性複製ストレス応答によるゲノム安定性維持機構の解明
文部科学省, 科学研究費補助金 若手研究(B)
Apr. 2015 - Mar. 2017

DNA複製のライセンス化制御
その他の研究制度