Inhibitory Effect of Pyra-Metho-Carnil on the Differentiation and Maturation of Macrophages in Normal and Cancer Microenvironments.
Takanori Kitaguchi; Taichi Matsumoto; Kazumasa Yoshida; Yuriko Hamaguchi; Gen Maruta; Hisanori Maeoka; Shuhei Ishikura; Michitaka Nakano; Yusuke Ishida; Fumihito Hirai; Mikiko Aoki; Shohta Kodama; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2024, 44(8):3557 - 3565

Inhibitory Effect of Pyra–Metho–Carnil on Cancer Spheroid Growth Through Decrease in Glycolysis-associated Molecules
KAZUMASA YOSHIDA; KENSUKE NISHI; SHUHEI ISHIKURA; TAICHI MATSUMOTO; KAZUHIKO NAKABAYASHI; RYO YAZAKI; TAKASHI OHSHIMA; MASAHIKO SUENAGA; SENJI SHIRASAWA; TOSHIYUKI TSUNODA
Anticancer Research, 26 Jul. 2023, 43(8):3717 - 3726

Death domain-associated protein DAXX regulates non-coding RNA transcription at the centromere through the transcription regulator ZFAT.
Shuhei Ishikura; Kazumasa Yoshida; Toshiyuki Tsunoda; Senji Shirasawa
The Journal of biological chemistry, 23 Sep. 2022, 298(11):102528 - 102528, Refereed
Lead

Cancer Spheroid Proliferation Is Suppressed by a Novel Low-toxicity Compound, Pyra-Metho-Carnil, in a Context-independent Manner.
Kazumasa Yoshida; Kensuke Nishi; Shuhei Ishikura; Kazuhiko Nakabayashi; Ryo Yazaki; Takashi Ohshima; Masahiko Suenaga; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2022, 42(8):3993 - 4001, Refereed

CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA.
Shuhei Ishikura; Kazumasa Yoshida; Sayuri Hashimoto; Kazuhiko Nakabayashi; Toshiyuki Tsunoda; Senji Shirasawa
The Journal of biological chemistry, Oct. 2021, 297(4):101213 - 101213, Refereed
Lead

Growth Suppression of Cancer Spheroids With Mutated KRAS by Low-toxicity Compounds from Natural Products.
Sayuri Hashimoto; Masayoshi Nagai; Kensuke Nishi; Shuhei Ishikura; Kazuhiko Nakabayashi; Ryo Yazaki; Takashi Ohshima; Masahiko Suenaga; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2021, 41(8):4061 - 4070, Refereed

The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes.
Shuhei Ishikura; Masayoshi Nagai; Toshiyuki Tsunoda; Kensuke Nishi; Yoko Tanaka; Midori Koyanagi; Senji Shirasawa
Journal of cellular biochemistry, Jun. 2021, 122(6):626 - 638, Refereed
Lead

ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B-H4K8ac-BRD4 axis.
Shuhei Ishikura; Kazuhiko Nakabayashi; Masayoshi Nagai; Toshiyuki Tsunoda; Senji Shirasawa
Nucleic acids research, 04 Nov. 2020, 48(19):10848 - 10866, Refereed
Lead

Mutant KRAS Promotes NKG2D+ T Cell Infiltration and CD155 Dependent Immune Evasion.
Kensuke Nishi; Shuhei Ishikura; Masayo Umebayashi; Takashi Morisaki; Takashi Inozume; Tetsushi Kinugasa; Mikiko Aoki; Satoshi Nimura; Anthony Swain; Yoichiro Yoshida; Suguru Hasegawa; Kazuki Nabeshima; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2020, 40(8):4663 - 4674, Refereed

Zfat Is Indispensable for the Development of Erythroid Cells in the Fetal Liver.
Keiko Doi; Toshiyuki Tsunoda; Midori Koyanagi; Yoko Tanaka; Shiori Yamano; Aya Fujikane; Kensuke Nishi; Shuhei Ishikura; Senji Shirasawa
Anticancer research, Aug. 2019, 39(8):4495 - 4502, Refereed

Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis.
Toshiyuki Tsunoda; Keiko Doi; Shuhei Ishikura; Hao Luo; Kensuke Nishi; Hiroshi Matsuzaki; Midori Koyanagi; Yoko Tanaka; Tadashi Okamura; Senji Shirasawa
International journal of molecular medicine, Nov. 2018, 42(5):2595 - 2603, Refereed
Lead

Growth Suppression of Human Colorectal Cancer Cells with Mutated KRAS by 3-Deaza-cytarabine in 3D Floating Culture.
Hao Luo; Kensuke Nishi; Shuhei Ishikura; Anthony Swain; Naoyuki Morishige; Ryo Yazaki; Takashi Ohshima; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Jul. 2018, 38(7):4247 - 4256, Refereed

ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line.
Kensuke Nishi; Yuri Iwaihara; Toshiyuki Tsunoda; Keiko Doi; Toshifumi Sakata; Senji Shirasawa; Shuhei Ishikura
Cell death & disease, 14 Dec. 2017, 8(12):3218 - 3218, Refereed
Last

Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS.
Kensuke Nishi; Hao Luo; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Lauren Wills; George S Baillie; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Jul. 2017, 37(7):3833 - 3839, Refereed

An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.
Kensuke Nishi; Hao Luo; Kazuhiko Nakabayashi; Keiko Doi; Shuhei Ishikura; Yuri Iwaihara; Yasuhiro Yoshida; Kumpei Tanisawa; Tomio Arai; Seijiro Mori; Motoji Sawabe; Masaaki Muramatsu; Masashi Tanaka; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Jul. 2017, 37(7):3855 - 3862, Refereed

Sequential cleavage of insulin receptor by calpain 2 and γ-secretase impairs insulin signalling.
Tomoyuki Yuasa; Kikuko Amo-Shiinoki; Shuhei Ishikura; Mitsuyoshi Takahara; Takaaki Matsuoka; Hideaki Kaneto; Akio Kuroda; Munehide Matsuhisa; Seiichi Hashida
Diabetologia, Dec. 2016, 59(12):2711 - 2721, Refereed

Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells.
Shuhei Ishikura; Toshiyuki Tsunoda; Kazuhiko Nakabayashi; Keiko Doi; Midori Koyanagi; Keiko Hayashi; Tomoko Kawai; Yoko Tanaka; Yuri Iwaihara; Hao Luo; Kensuke Nishi; Tadashi Okamura; Senji Shirasawa
Biochimica et biophysica acta, Nov. 2016, 1859(11):1398 - 1410, Refereed
Lead

The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway.
Shuhei Ishikura; Yuri Iwaihara; Yoko Tanaka; Hao Luo; Kensuke Nishi; Keiko Doi; Midori Koyanagi; Tadashi Okamura; Toshiyuki Tsunoda; Senji Shirasawa
The Journal of biological chemistry, 15 Jul. 2016, 291(29):15282 - 91, Refereed
Lead

Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells.
Yuri Iwaihara; Shuhei Ishikura; Keiko Doi; Toshiyuki Tsunoda; Takahiro Fujimoto; Tadashi Okamura; Senji Shirasawa
Anticancer research, Aug. 2015, 35(8):4419 - 23, Refereed

Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules.
Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Hiromasa Hidesima; Hao Luo; Yumiko Hirose; Senji Shirasawa
Anticancer research, Aug. 2015, 35(8):4453 - 9, Refereed

Zfat-deficient CD4⁺ CD8⁺ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.
Shuhei Ishikura; Masahiro Ogawa; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Yoko Tanaka; Toshiyuki Tsunoda; Hiromasa Hideshima; Tadashi Okamura; Senji Shirasawa
Journal of cellular biochemistry, Jan. 2015, 116(1):149 - 57, Refereed
Lead

The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.
Keiko Doi; Shuhei Ishikura; Senji Shirasawa
Anticancer research, Aug. 2014, 34(8):4489 - 95, Refereed

Resveratrol induces luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture.
Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Senji Shirasawa
Anticancer research, Aug. 2014, 34(8):4551 - 5, Refereed

Ca²⁺ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells.
Q Li; X Zhu; S Ishikura; D Zhang; J Gao; Y Sun; A Contreras-Ferrat; K P Foley; S Lavandero; Z Yao; P J Bilan; A Klip; W Niu
American journal of physiology. Endocrinology and metabolism, 15 Jul. 2014, 307(2):E209-24, Refereed

Development of in vitro model of insulin receptor cleavage induced by high glucose in HepG2 cells.
Tomoyuki Yuasa; Kikuko Amo; Shuhei Ishikura; Hisao Nagaya; Keiji Uchiyama; Seiichi Hashida; Yousuke Ebina
Biochemical and biophysical research communications, 28 Feb. 2014, 445(1):236 - 43, Refereed

Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.
Masahiro Ogawa; Tadashi Okamura; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yoko Tanaka; Takeharu Ota; Kunihiro Hayakawa; Harumi Suzuki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
PloS one, 03 Oct. 2013, 8(10):e76254, Refereed

Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein.
Shuhei Ishikura; Allan M Weissman; Juan S Bonifacino
The Journal of biological chemistry, 30 Jul. 2010, 285(31):23916 - 24, Refereed
Lead

Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells.
Wenyan Niu; Philip J Bilan; Shuhei Ishikura; Jonathan D Schertzer; Ariel Contreras-Ferrat; Zhengxiang Fu; Jie Liu; Shlomit Boguslavsky; Kevin P Foley; Zhi Liu; Jinru Li; Guilan Chu; Thomas Panakkezhum; Gary D Lopaschuk; Sergio Lavandero; Zhi Yao; Amira Klip
American journal of physiology. Endocrinology and metabolism, May 2010, 298(5):E1058-71, Refereed

Documenting GLUT4 exocytosis and endocytosis in muscle cell monolayers.
Shuhei Ishikura; Costin N Antonescu; Amira Klip
Current protocols in cell biology, Mar. 2010, Chapter 15:Unit 15.15, Refereed
Lead

The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2.
Sean M Hartig; Shuhei Ishikura; Rachel S Hicklen; Yanming Feng; Elisabeth G Blanchard; Kevin A Voelker; Christina S Pichot; Robert W Grange; Robert M Raphael; Amira Klip; Seth J Corey
Journal of cell science, 01 Jul. 2009, 122(Pt 13):2283 - 91, Refereed

Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase.
H-T Zhao; S Endo; S Ishikura; R Chung; P J Hogg; A Hara; O El-Kabbani
Cellular and molecular life sciences : CMLS, May 2009, 66(9):1570 - 9, Refereed

GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.
Varinder K Randhawa; Shuhei Ishikura; Ilana Talior-Volodarsky; Alex W P Cheng; Nish Patel; John H Hartwig; Amira Klip
The Journal of biological chemistry, 03 Oct. 2008, 283(40):27208 - 19, Refereed

Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.
Shuhei Ishikura; Amira Klip
American journal of physiology. Cell physiology, Oct. 2008, 295(4):C1016-25, Refereed
Lead

Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity.
Toshiyuki Matsunaga; Satoshi Endo; Satoshi Maeda; Shuhei Ishikura; Kazuo Tajima; Nobutada Tanaka; Kazuo T Nakamura; Yorishige Imamura; Akira Hara
Archives of biochemistry and biophysics, 15 Sep. 2008, 477(2):339 - 47, Refereed

Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid.
Vincenzo Carbone; Rie Sumii; Shuhei Ishikura; Yukuhiko Asada; Akira Hara; Ossama El-Kabbani
Acta crystallographica. Section D, Biological crystallography, May 2008, 64(Pt 5):532 - 42, Refereed

Molecular basis for peroxisomal localization of tetrameric carbonyl reductase.
Nobutada Tanaka; Ken-Ichi Aoki; Shuhei Ishikura; Makoto Nagano; Yorishige Imamura; Akira Hara; Kazuo T Nakamura
Structure (London, England : 1993), Mar. 2008, 16(3):388 - 97, Refereed

Small G proteins in insulin action: Rab and Rho families at the crossroads of signal transduction and GLUT4 vesicle traffic.
S Ishikura; A Koshkina; A Klip
Acta physiologica (Oxford, England), Jan. 2008, 192(1):61 - 74, Refereed
Lead

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.
Satoshi Endo; Masaharu Sanai; Kenji Horie; Toshiyuki Matsunaga; Shuhei Ishikura; Kazuo Tajima; Ossama El-Kabbani; Akira Hara
Archives of biochemistry and biophysics, 01 Nov. 2007, 467(1):76 - 86, Refereed

Characterization of an oligomeric carbonyl reductase of dog liver: its identity with peroxisomal tetrameric carbonyl reductase.
Satoshi Endo; Toshiyuki Matsunaga; Makoto Nagano; Hiroko Abe; Syuhei Ishikura; Yorishige Imamura; Akira Hara
Biological & pharmaceutical bulletin, Sep. 2007, 30(9):1787 - 91, Refereed

Rat NAD+-dependent 3alpha-hydroxysteroid dehydrogenase (AKR1C17): a member of the aldo-keto reductase family highly expressed in kidney cytosol.
Masaharu Sanai; Satoshi Endo; Toshiyuki Matsunaga; Shuhei Ishikura; Kazuo Tajima; Ossama El-Kabbani; Akira Hara
Archives of biochemistry and biophysics, 01 Aug. 2007, 464(1):122 - 9, Refereed

Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells.
Shuhei Ishikura; Philip J Bilan; Amira Klip
Biochemical and biophysical research communications, 23 Feb. 2007, 353(4):1074 - 9, Refereed
Lead

Stereoselective reduction of 4-benzoylpyridine in the heart of vertebrates.
Hideaki Shimada; Koji Imaishi; Takaomi Hirashima; Takeshi Kitano; Shuhei Ishikura; Akira Hara; Yorishige Imamura
Life sciences, 16 Jan. 2007, 80(6):554 - 8, Refereed

Substrate specificity of a mouse aldo-keto reductase (AKR1C12).
Satoshi Endo; Kengo Matsumoto; Toshiyuki Matsunaga; Shuhei Ishikura; Kazuo Tajima; Ossama El-Kabbani; Akira Hara
Biological & pharmaceutical bulletin, Dec. 2006, 29(12):2488 - 92, Refereed

Crystallization and preliminary X-ray crystallographic studies of pig heart carbonyl reductase.
Ken-ichi Aoki; Nobutada Tanaka; Shuhei Ishikura; Naoko Araki; Yorishige Imamura; Akira Hara; Kazuo T Nakamura
Acta crystallographica. Section F, Structural biology and crystallization communications, 01 Oct. 2006, 62(Pt 10):1037 - 40, Refereed

Molecular cloning of a novel type of rat cytoplasmic 17beta-hydroxysteroid dehydrogenase distinct from the type 5 isozyme.
Shuhei Ishikura; Kengo Matsumoto; Masaharu Sanai; Kenji Horie; Toshiyuki Matsunaga; Kazuo Tajima; Ossama El-Kabbani; Akira Hara
Journal of biochemistry, Jun. 2006, 139(6):1053 - 63, Refereed
Lead

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.
Kengo Matsumoto; Satoshi Endo; Shuhei Ishikura; Toshiyuki Matsunaga; Kazuo Tajima; Ossama El-Kabbani; Akira Hara
Biological & pharmaceutical bulletin, Mar. 2006, 29(3):539 - 42, Refereed

Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.
Ossama El-Kabbani; Vincenzo Carbone; Connie Darmanin; Syuhei Ishikura; Akira Hara
Proteins, 15 Aug. 2005, 60(3):424 - 32, Refereed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.
Ossama El-Kabbani; Syuhei Ishikura; Armin Wagner; Clemens Schulze-Briese; Akira Hara
Acta crystallographica. Section F, Structural biology and crystallization communications, 01 Jul. 2005, 61(Pt 7):688 - 90, Refereed

Enzymatic properties of a member (AKR1C19) of the aldo-keto reductase family.
Shuhei Ishikura; Kenji Horie; Masaharu Sanai; Kengo Matsumoto; Akira Hara
Biological & pharmaceutical bulletin, Jun. 2005, 28(6):1075 - 8, Refereed
Lead

Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase.
Syuhei Ishikura; Noriyuki Usami; Mayuko Araki; Akira Hara
Journal of biochemistry, Mar. 2005, 137(3):303 - 14, Refereed
Lead

Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking.
Vincenzo Carbone; Syuhei Ishikura; Akira Hara; Ossama El-Kabbani
Bioorganic & medicinal chemistry, 17 Jan. 2005, 13(2):301 - 12, Refereed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.
Syuhei Ishikura; Noriyuki Usami; Satoko Nakajima; Akiko Kameyama; Hiroaki Shiraishi; Vincenzo Carbone; Ossama El-Kabbani; Akira Hara
Biological & pharmaceutical bulletin, Dec. 2004, 27(12):1939 - 45, Refereed
Lead

Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis.
Ossama El-Kabbani; Shuhei Ishikura; Connie Darmanin; Vincenzo Carbone; Roland P-T Chung; Noriyuki Usami; Akira Hara
Proteins, 15 May 2004, 55(3):724 - 32, Refereed

Structural determinant for cold inactivation of rodent L-xylulose reductase.
Shuhei Ishikura; Noriyuki Usami; Ossama El-Kabbani; Akira Hara
Biochemical and biophysical research communications, 15 Aug. 2003, 308(1):68 - 72, Refereed
Lead

Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
Teruhiko Iino; Mayuko Tabata; Shin-Ichiro Takikawa; Hiroshi Sawada; Haruo Shintaku; Shuhei Ishikura; Akira Hara
Archives of biochemistry and biophysics, 15 Aug. 2003, 416(2):180 - 7, Refereed

Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme.
Vincenzo Carbone; Connie Darmanin; Shuhei Ishikura; Akira Hara; Ossama El-Kabbani
Bioorganic & medicinal chemistry letters, 17 Apr. 2003, 13(8):1469 - 74, Refereed

Cloning, expression and tissue distribution of a tetrameric form of pig carbonyl reductase.
Noriyuki Usami; Shuhei Ishikura; Hiroko Abe; Makoto Nagano; Miki Uebuchi; Akihiko Kuniyasu; Masaki Otagiri; Hitoshi Nakayama; Yorishige Imamura; Akira Hara
Chemico-biological interactions, 01 Feb. 2003, 143-144:353 - 61, Refereed

Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone.
Yu Higaki; Noriyuki Usami; Syunichi Shintani; Shuhei Ishikura; Ossama El-Kabbani; Akira Hara
Chemico-biological interactions, 01 Feb. 2003, 143-144:503 - 13, Refereed

Identification of amino acid residues involved in substrate recognition of L-xylulose reductase by site-directed mutagenesis.
Shuhei Ishikura; Tomoya Isaji; Noriyuki Usami; Junichi Nakagawa; Ossama El-Kabbani; Akira Hara
Chemico-biological interactions, 01 Feb. 2003, 143-144:543 - 50, Refereed
Lead

Crystallization and preliminary crystallographic analysis of human L-xylulose reductase.
Ossama El-Kabbani; Roland P T Chung; Syuhei Ishikura; Noriyuki Usami; Junichi Nakagawa; Akira Hara
Acta crystallographica. Section D, Biological crystallography, Aug. 2002, 58(Pt 8):1379 - 80, Refereed

Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.
Junichi Nakagawa; Syuhei Ishikura; Jun Asami; Tomoya Isaji; Noriyuki Usami; Akira Hara; Takanobu Sakurai; Katsuki Tsuritani; Koji Oda; Masayoshi Takahashi; Makoto Yoshimoto; Noboru Otsuka; Kunihiro Kitamura
The Journal of biological chemistry, 17 May 2002, 277(20):17883 - 91, Refereed

Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines.
Noriyuki Usami; Tomohiro Yamamoto; Syunichi Shintani; Shuhei Ishikura; Yu Higaki; Yoshihiro Katagiri; Akira Hara
Biological & pharmaceutical bulletin, Apr. 2002, 25(4):441 - 5, Refereed

Crystallization and preliminary X-ray diffraction analysis of monkey dimeric dihydrodiol dehydrogenase.
Ossama El-Kabbani; Roland P T Chung; Paul A Ramsland; Yukuhiko Asada; Syuhei Ishikura; Noriyuki Usami; Akira Hara
Acta crystallographica. Section D, Biological crystallography, Jan. 2002, 58(Pt 1):163 - 4, Refereed

Molecular characterization of two monkey dihydrodiol dehydrogenases.
Yu Higaki; Takeshi Kamiya; Noriyuki Usami; Syunichi Shintani; Hiroaki Shiraishi; Shuhei Ishikura; Ikuo Yamamoto; Akira Hara
Drug metabolism and pharmacokinetics, 2002, 17(4):348 - 56, Refereed

Characterization of a major form of human isatin reductase and the reduced metabolite.
N Usami; K Kitahara; S Ishikura; M Nagano; S Sakai; A Hara
European journal of biochemistry, Nov. 2001, 268(22):5755 - 63, Refereed

Identity of dimeric dihydrodiol dehydrogenase as NADP(+)-dependent D-xylose dehydrogenase in pig liver.
S Aoki; S Ishikura; Y Asada; N Usami; A Hara
Chemico-biological interactions, 30 Jan. 2001, 130-132(1-3):775 - 84, Refereed

Molecular cloning, expression and tissue distribution of hamster diacetyl reductase. Identity with L-xylulose reductase.
S Ishikura; T Isaji; N Usami; K Kitahara; J Nakagawa; A Hara
Chemico-biological interactions, 30 Jan. 2001, 130-132(1-3):879 - 89, Refereed
Lead

Enzymatic characteristics and subcellular distribution of a short-chain dehydrogenase/reductase family protein, P26h, in hamster testis and epididymis.
S Ishikura; N Usami; K Kitahara; T Isaji; K Oda; J Nakagawa; A Hara
Biochemistry, 09 Jan. 2001, 40(1):214 - 24, Refereed
Lead

Kinetic alteration of a human dihydrodiol/3alpha-hydroxysteroid dehydrogenase isoenzyme, AKR1C4, by replacement of histidine-216 with tyrosine or phenylalanine.
T Ohta; S Ishikura; S Shintani; N Usami; A Hara
The Biochemical journal, 15 Dec. 2000, 352 Pt 3:685 - 91, Refereed

Roles of His-79 and Tyr-180 of D-xylose/dihydrodiol dehydrogenase in catalytic function.
Y Asada; S Aoki; S Ishikura; N Usami; A Hara
Biochemical and biophysical research communications, 19 Nov. 2000, 278(2):333 - 7, Refereed

Structure-specific effects of thyroxine analogs on human liver 3 alpha-hydroxysteroid dehydrogenase.
T Yamamoto; A Nozaki; S Shintani; S Ishikura; Y Katagiri; A Hara
Journal of biochemistry, Jul. 2000, 128(1):121 - 8, Refereed

Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases.
E Arimitsu; S Aoki; S Ishikura; K Nakanishi; K Matsuura; A Hara
The Biochemical journal, 15 Sep. 1999, 342 Pt 3:721 - 8, Refereed

Inhibition of human aldehyde reductase by drugs for testing the function of liver and kidney.
M Shinoda; S Mori; S Shintani; S Ishikura; A Hara
Biological & pharmaceutical bulletin, Jul. 1999, 22(7):741 - 4, Refereed

Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimaeric enzymes.
K Matsuura; A Hara; Y Deyashiki; H Iwasa; T Kume; S Ishikura; H Shiraishi; Y Katagiri
The Biochemical journal, 01 Dec. 1998, 336 ( Pt 2):429 - 36, Refereed

Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA.
H Shiraishi; S Ishikura; K Matsuura; Y Deyashiki; M Ninomiya; S Sakai; A Hara
The Biochemical journal, 01 Sep. 1998, 334 ( Pt 2):399 - 405, Refereed

Properties and tissue distribution of mouse monomeric carbonyl reductase.
S Ishikura; Y Yamamoto; K Matsuura; J Wei; M E Hodes; A Hara
Biological & pharmaceutical bulletin, Aug. 1998, 21(8):879 - 81, Refereed
Lead

Activation of human liver 3alpha-hydroxysteroid dehydrogenase by clofibrate derivatives.
K Matsuura; A Hara; M Kato; Y Deyashiki; Y Miyabe; S Ishikura; T Sugiyama; Y Katagiri
The Journal of pharmacology and experimental therapeutics, Jun. 1998, 285(3):1096 - 103, Refereed

日本生化学会

セントロメアDNA損傷修復におけるZFATの役割とB細胞リンパ腫との関連の解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2023 - 31 Mar. 2026

ZfatによるセントロメアノンコーディングRNA転写制御機構とガンとの関連の解明
日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
福岡大学
01 Apr. 2020 - 31 Mar. 2023

可溶性インスリン受容体による血中インスリンの不活化と糖尿病
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B)
01 Apr. 2012 - 31 Mar. 2014

神経ステロイド代謝酵素を標的とする医薬品の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Gifu Pharmaceutical University
1999 - 2001