Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation.
Taro Hiromi; Utako Yokoyama; Daisuke Kurotaki; Al Mamun; Ryo Ishiwata; Yasuhiro Ichikawa; Hiroshi Nishihara; Masanari Umemura; Takayuki Fujita; Shota Yasuda; Tomoyuki Minami; Motohiko Goda; Keiji Uchida; Shinichi Suzuki; Ichiro Takeuchi; Munetaka Masuda; Richard M Breyer; Tomohiko Tamura; Yoshihiro Ishikawa
Arteriosclerosis, thrombosis, and vascular biology, 23 Apr. 2020, 40(6):ATVBAHA120314297 - 1573, Refereed

Fibulin-1 integrates subendothelial extracellular matrices and contributes to anatomical closure of the ductus arteriosus
Ito S; Yokoyama U; Nakakoji T; Cooley M; Sasaki T; Hatano S; Kato Y; Saito J; Nicho N; Iwasaki S; Umemura M; Fujita T; Masuda M; Aso T; Ishikawa T
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, in press, Refereed

Prostaglandin E₂ receptor EP4 regulates cell migration via Orai1.
Osawa K; Umemura M; Nakakaji R; Tanaka R; Islam RM; Nagasako A; Fujita T; Yokoyama U; Koizumi T; Mitsudo K; Ishikawa Y
Cancer science, Nov. 2019, Refereed

Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism.
Cell Death Dis., Jul. 2019, 18;10(8):549., Refereed
Corresponding

Correction to: Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.
Huiling Jin; Takayuki Fujita; Meihua Jin; Reiko Kurotani; Yuko Hidaka; Wenqian Cai; Kenji Suita; Rajesh Prajapati; Chen Liang; Yoshiki Ohnuki; Yasumasa Mototani; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Satoshi Okumura; Yoshihiro Ishikawa
The journal of physiological sciences : JPS, May 2019, 69(3):557 - 557

Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration.
Yuko Kato; Utako Yokoyama; Takayuki Fujita; Masanari Umemura; Tetsuo Kubota; Yoshihiro Ishikawa
The journal of physiological sciences : JPS, Mar. 2019, 69(2):175 - 184, Refereed

Reactive Fibrosis Precedes Doxorubicin-induced Heart Failure through Sterile Inflammation, and Pioglitazone Reduces Early Cardiac Remodelling
Tanaka R; Umemura M; Narikawa M; Hikichi M; Osawa K; Fujita T; Yokoyama U; Ishigami T; Kimura K; Tamura K; Ishikawa Y
ESC Heart Failure. in press, 2019, Refereed

Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways.
Narikawa M; Umemura M; Tanaka R; Hikichi M; Nagasako A; Fujita T; Yokoyama U; Ishigami T; Kimura K; Tamura K; Ishikawa Y
PloS one, 2019, 14(9):e0221940, Refereed

Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice.
Rajesh Prajapati; Takayuki Fujita; Kenji Suita; Takashi Nakamura; Wenqian Cai; Yuko Hidaka; Masanari Umemura; Utako Yokoyama; Björn C Knollmann; Satoshi Okumura; Yoshihiro Ishikawa
Circ J., Jan. 2019, 83(2):295 - 303, Refereed
Corresponding

Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling.
Masatoshi Narikawa; Masanari Umemura; Ryo Tanaka; Takayuki Fujita; Utako Yokoyama; Tomoaki Ishigami; Kazuo Kimura; Kouichi Tamura; Yoshihiro Ishikawa
Scientific Reports, 01 Dec. 2018, 8(1):6277, Refereed

Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor.
Umemura M; Islam MR; Fukumura H; Sato I; Kawabata Y; Matsuo K; Nakakaji R; Nagasako A; Ohtake M; Fujita T; Yokoyama U; Nakayama T; Eguchi H; Ishikawa Y
Cancer science, Oct. 2018, 110(1):356 - 365, Refereed

A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm.
Mamun A; Yokoyama U; Saito J; Ito S; Hiromi T; Umemura M; Fujita T; Yasuda S; Minami T; Goda M; Uchida K; Suzuki S; Masuda M; Ishikawa Y
Physiological reports, Sep. 2018, 6(18):e13878 - e13878, Refereed

Alternating magnetic field enhances cytotoxicity of Compound C.
Akimoto T; Umemura M; Nagasako A; Ohtake M; Fujita T; Yokoyama U; Eguchi H; Yamamoto T; Ishikawa Y
Cancer science, Aug. 2018, 109(11):3483 - 3493, Refereed

Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice
Kenji Suita; Takayuki Fujita; Wenqian Cai; Yuko Hidaka; Huiling Jin; Rajesh Prajapati; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Björn C. Knollmann; Satoshi Okumura; Yoshihiro Ishikawa
Pflugers Archiv European Journal of Physiology, 01 Jun. 2018, 470(6):923 - 935, Refereed

Hydrostatic pressure suppresses fibrotic changes via Akt/GSK-3 signaling in human cardiac fibroblasts
Ryo Tanaka; Masanari Umemura; Masatoshi Narikawa; Takayuki Fujita; Utako Yokoyama; Tomoaki Ishigami; Kazuo Kimura; Kouichi Tamura; Yoshihiro Ishikawa
Physiological Reports, 01 May 2018, 6(9):e13687, Refereed

Epac activation inhibits IL-6-induced cardiac myocyte dysfunction
Huiling Jin; Takayuki Fujita; Meihua Jin; Reiko Kurotani; Yuko Hidaka; Wenqian Cai; Kenji Suita; Rajesh Prajapati; Chen Liang; Yoshiki Ohnuki; Yasumasa Mototani; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Satoshi Okumura; Yoshihiro Ishikawa
Journal of Physiological Sciences, 01 Jan. 2018, 68(1):77 - 87, Refereed

Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus
Junichi Saito; Utako Yokoyama; Naoki Nicho; Yun-Wen Zheng; Yasuhiro Ichikawa; Satoko Ito; Masanari Umemura; Takayuki Fujita; Shuichi Ito; Hideki Taniguchi; Toshihide Asou; Munetaka Masuda; Yoshihiro Ishikawa
PLoS ONE, 01 Jan. 2018, 13(1):e0190871, Refereed

Treatment of oral cancer using magnetized paclitaxel
Rina Nakakaji; Masanari Umemura; Kenji Mitsudo; Jeong-Hwan Kim; Yujiro Hoshino; Itaru Sato; Takatsugu Masuda; Masahiro Yamamoto; Mitomu Kioi; Toshiyuki Koizumi; Takayuki Fujita; Utako Yokoyama; Masaki Iida; Motohiko Sato; Hiroshi Sato; Shoko Murofushi; Sayaka Shibata; Ichio Aoki; Haruki Eguchi; Iwai Tohnai; Yoshihiro Ishikawa
Oncotarget, 2018, 9(21):15591 - 15605, Refereed

The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity
Masanari Umemura; Jeong-Hwan Kim; Haruki Aoyama; Yujiro Hoshino; Hidenobu Fukumura; Rina Nakakaji; Itaru Sato; Makoto Ohtake; Taisuke Akimoto; Masatoshi Narikawa; Ryo Tanaka; Takayuki Fujita; Utako Yokoyama; Masataka Taguri; Satoshi Okumura; Motohiko Sato; Haruki Eguchi; Yoshihiro Ishikawa
JOURNAL OF PHARMACOLOGICAL SCIENCES, Aug. 2017, 134(4):203 - 210, Refereed

Transient receptor potential cation 3 channel regulates melanoma proliferation and migration
Kayoko Oda; Masanari Umemura; Rina Nakakaji; Ryo Tanaka; Itaru Sato; Akane Nagasako; Chiaki Oyamada; Erdene Baljinnyam; Mayumi Katsumata; Lai-Hua Xie; Masatoshi Narikawa; Yukie Yamaguchi; Taisuke Akimoto; Makoto Ohtake; Takayuki Fujita; Utako Yokoyama; Kousaku Iwatsubo; Michiko Aihara; Yoshihiro Ishikawa
JOURNAL OF PHYSIOLOGICAL SCIENCES, Jul. 2017, 67(4):497 - 505, Refereed

Cardiac overexpression of Epacl in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway
Huiling Jin; Takayuki Fujita; Meihua Jin; Reiko Kurotani; Iyuki Namekata; Shogo Hamaguchi; Yuko Hidaka; Wenqian Cai; Kenji Suita; Yoshiki Ohnuki; Yasumasa Mototani; Kouichi Shiozawa; Rajesh Prajapati; Chen Liang; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Hikaru Tanaka; Satoshi Okumura; Yoshihiro Ishikawa
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Jul. 2017, 108:170 - 180, Refereed

Arterial graft with elastic layer structure grown from cells
Utako Yokoyama; Yuta Tonooka; Ryoma Koretake; Taisuke Akimoto; Yuki Gonda; Junichi Saito; Masanari Umemura; Takayuki Fujita; Shinya Sakuma; Fumihito Arai; Makoto Kaneko; Yoshihiro Ishikawa
SCIENTIFIC REPORTS, Mar. 2017, 7(1):140, Refereed

Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment
Makoto Ohtake; Masanari Umemura; Itaru Sato; Taisuke Akimoto; Kayoko Oda; Akane Nagasako; Jeong-Hwan Kim; Takayuki Fujita; Utako Yokoyama; Tomohiro Nakayama; Yujiro Hoshino; Mai Ishiba; Susumu Tokura; Masakazu Hara; Tomoya Muramoto; Sotoshi Yamada; Takatsugu Masuda; Ichio Aoki; Yasushi Takemura; Hidetoshi Murata; Haruki Eguchi; Nobutaka Kawahara; Yoshihiro Ishikawa
Scientific Reports, 20 Feb. 2017, 7:42783, Refereed

The role of Epac in the heart
Takayuki Fujita; Masanari Umemura; Utako Yokoyama; Satoshi Okumura; Yoshihiro Ishikawa
CELLULAR AND MOLECULAR LIFE SCIENCES, Feb. 2017, 74(4):591 - 606, Refereed

Vidarabine, an Anti-Herpes Virus Agent, Protects Against the Development of Heart Failure With Relatively Mild Side-Effects on Cardiac Function in a Canine Model of Pacing-Induced Dilated Cardiomyopathy
Takashi Nakamura; Takayuki Fujita; Megumi Kishimura; Kenji Suita; Yuko Hidaka; Wenqian Cai; Masanari Umemura; Utako Yokoyama; Masami Uechi; Yoshihiro Ishikawa
CIRCULATION JOURNAL, Dec. 2016, 80(12):2496 - +, Refereed

Glutamate Promotes Contraction of the Rat Ductus Arteriosus
Shujiro Fujita; Utako Yokoyama; Ryo Ishiwata; Rika Aoki; Kenji Nagao; Daiki Masukawa; Masanari Umemura; Takayuki Fujita; Shiho Iwasaki; Shigeru Nishimaki; Kazuo Seki; Shuichi Ito; Yoshio Goshima; Toshihide Asou; Munetaka Masuda; Yoshihiro Ishikawa
CIRCULATION JOURNAL, Nov. 2016, 80(11):2388 - 2396, Refereed

Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction
Wenqian Cai; Takayuki Fujita; Yuko Hidaka; Huiling Jin; Kenji Suita; Rajesh Prajapati; Chen Liang; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Satoshi Okumura; Yoshihiro Ishikawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2016, 475(1):1 - 7, Refereed

Role of phosphodiesterase 4 expression in the Epac1 signaling-dependent skeletal muscle hypertrophic action of clenbuterol
Yoshiki Ohnuki; Daisuke Umeki; Yasumasa Mototani; Kouichi Shiozawa; Megumi Nariyama; Aiko Ito; Naoya Kawamura; Yuka Yagisawa; Huiling Jin; Wenqian Cai; Kenji Suita; Yasutake Saeki; Takayuki Fujita; Yoshihiro Ishikawa; Satoshi Okumura
Physiological Reports, 01 May 2016, 4(10), Refereed

Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles
Itaru Sato; Masanari Umemura; Kenji Mitsudo; Hidenobu Fukumura; Jeong-Hwan Kim; Yujiro Hoshino; Hideyuki Nakashima; Mitomu Kioi; Rina Nakakaji; Motohiko Sato; Takayuki Fujita; Utako Yokoyama; Satoshi Okumura; Hisashi Oshiro; Haruki Eguchi; Iwai Tohnai; Yoshihiro Ishikawa
SCIENTIFIC REPORTS, Apr. 2016, 6:24629, Refereed

Decreased serum osmolality promotes ductus arteriosus constriction
Rika Aoki; Utako Yokoyama; Yasuhiro Ichikawa; Masataka Taguri; Shun Kumagaya; Ryo Ishiwata; Chiharu Yanai; Shujiro Fujita; Masanari Umemura; Takayuki Fujita; Satoshi Okumura; Motohiko Sato; Susumu Minamisawa; Toshihide Asou; Munetaka Masuda; Shiho Iwasaki; Shigeru Nishimaki; Kazuo Seki; Shumpei Yokota; Yoshihiro Ishikawa
CARDIOVASCULAR RESEARCH, Nov. 2014, 104(2):326 - 336, Refereed

Effects of Protein Kinase A on the Phosphorylation Status and Transverse Stiffness of Cardiac Myofibrils
Yoshiki Ohnuki; Takenori Yamada; Yasumasa Mototani; Daisuke Umeki; Kouichi Shiozawa; Takayuki Fujita; Yasutake Saeki; Satoshi Okumura
JOURNAL OF PHARMACOLOGICAL SCIENCES, Nov. 2013, 123(3):279 - 283, Refereed

Role of Masseter Muscle beta(2)-Adrenergic Signaling in Regulation of Muscle Activity, Myosin Heavy Chain Transition, and Hypertrophy
Yoshiki Ohnuki; Daisuke Umeki; Wenqian Cai; Nobuhiko Kawai; Yasumasa Mototani; Kouichi Shiozawa; Hui-Ling Jin; Takayuki Fujita; Eiji Tanaka; Yasutake Saeki; Satoshi Okumura
JOURNAL OF PHARMACOLOGICAL SCIENCES, Sep. 2013, 123(1):36 - 46, Refereed

Effects of Chronic Akt/mTOR Inhibition by Rapamycin on Mechanical Overload-Induced Hypertrophy and Myosin Heavy Chain Transition in Masseter Muscle
Daisuke Umeki; Yoshiki Ohnuki; Yasumasa Mototani; Kouichi Shiozawa; Takayuki Fujita; Yoshiki Nakamura; Yasutake Saeki; Satoshi Okumura
JOURNAL OF PHARMACOLOGICAL SCIENCES, Aug. 2013, 122(4):278 - 288, Refereed

The Prostanoid EP4 Receptor and Its Signaling Pathway
Utako Yokoyama; Kousaku Iwatsubo; Masanari Umemura; Takayuki Fujita; Yoshihiro Ishikawa
PHARMACOLOGICAL REVIEWS, Jul. 2013, 65(3):1010 - 1052, Refereed

Low-dose thromboxane A(2) receptor stimulation promotes closure of the rat ductus arteriosus with minimal adverse effects
Tomohiro Yokota; Takashi Aida; Yasuhiro Ichikawa; Takayuki Fujita; Utako Yokoyama; Susumu Minamisawa
PEDIATRIC RESEARCH, Aug. 2012, 72(2):129 - 136, Refereed

Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight
Yunzhe Bai; Takashi Tsunematsu; Qibin Jiao; Yoshiki Ohnuki; Yasumasa Mototani; Kouichi Shiozawa; Meihua Jin; Wenqian Cai; Hui-Ling Jin; Takayuki Fujita; Yasuhiro Ichikawa; Kenji Suita; Reiko Kurotani; Utako Yokoyama; Motohiko Sato; Kousaku Iwatsubo; Yoshihiro Ishikawa; Satoshi Okumura
JOURNAL OF PHARMACOLOGICAL SCIENCES, Aug. 2012, 119(4):381 - 389, Refereed

Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells
Hidenobu Fukumura; Motohiko Sato; Kyouhei Kezuka; Itaru Sato; Xianfeng Feng; Satoshi Okumura; Takayuki Fujita; Utako Yokoyama; Haruki Eguchi; Yoshihiro Ishikawa; Tomoyuki Saito
JOURNAL OF PHYSIOLOGICAL SCIENCES, May 2012, 62(3):251 - 257, Refereed

Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation
Utako Yokoyama; Ryo Ishiwata; Mei-Hua Jin; Yuko Kato; Orie Suzuki; Huiling Jin; Yasuhiro Ichikawa; Syun Kumagaya; Yuzo Katayama; Takayuki Fujita; Satoshi Okumura; Motohiko Sato; Yukihiko Sugimoto; Hiroki Aoki; Shinichi Suzuki; Munetaka Masuda; Susumu Minamisawa; Yoshihiro Ishikawa
PLOS ONE, May 2012, 7(5):e36724, Refereed

The Roles of Cytochrome P450 in Ischemic Heart Disease
Motohiko Sato; Utako Yokoyama; Takayuki Fujita; Satoshi Okumura; Yoshihioro Ishikawa
CURRENT DRUG METABOLISM, Jul. 2011, 12(6):526 - 532, Refereed

Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca2+-dependent manner
Takayuki Fujita; Kouji Otsu; An Oshikawa; Hideaki Hori; Hitoshi Kitamura; Takaaki Ito; Satoshi Umemura; Susumu Minamisawa; Yoshihiro Ishikawa
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, Jan. 2006, 10(1):216 - 224, Refereed

Nicotinic acetylcholine receptor alpha(7) regulates cAMP signal within lipid rafts
J Oshikawa; Y Toya; T Fujita; M Egawa; J Kawabe; S Umemura; Y Ishikawa
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, Sep. 2003, 285(3):C567 - C574, Refereed

Ischemic preconditioning prevents ischemia-induced beta-adrenergic receptor sequestration
K Iwatsubo; Y Toya; T Fujita; T Ebina; C Schwencke; S Minamisawa; S Umemura; Y Ishikawa
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Aug. 2003, 35(8):923 - 929, Refereed

Characterization of beta-adrenergic receptor sequestration by newly developed whole cell binding assays.
Iwatsubo K; Tao Y; Onda T; Toya Y; Schwencke C; Fujita T; Ebina T; Iwamoto T; Hori H; Minamisawa S; Umemura S; Ishikawa Y
Journal of cardiovascular pharmacology, Jan. 2003, 41 Suppl 1:S53 - 6, Refereed

生体侵襲とショックの基礎病態学、今 急性と慢性 心不全はどこがちがうのか?
石川 義弘; 藤田 孝之; 梅村 将就; 横山 詩子
Shock: 日本Shock学会雑誌, Feb. 2019, 33(2):34 - 39

Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation
Yuko Kato; Utako Yokoyama; Chiharu Yanai; Rina Ishige; Daisuke Kurotaki; Masanari Umemura; Takayuki Fujita; Tetsuo Kubota; Satoshi Okumura; Masataka Sata; Tomohiko Tamura; Yoshihiro Ishikawa
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Dec. 2015, 35(12):2617 - 2625

Norepinephrine-induced adrenergic activation strikingly increased the atrial fibrillation duration through (β1- and α1-adrenergic receptor-mediated signaling in mice
Kenji Suita; Takayuki Fujita; Nozomi Hasegawa; Wenqian Cai; Huiling Jin; Yuko Hidaka; Rajesh Prajapati; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Satoshi Okumura; Yoshihiro Ishikawa
PLOS ONE, Jul. 2015, 10(7)

Protective Effects of Clenbuterol against Dexamethasone-Induced Masseter Muscle Atrophy and Myosin Heavy Chain Transition
Daisuke Umeki; Yoshiki Ohnuki; Yasumasa Mototani; Kouichi Shiozawa; Kenji Suita; Takayuki Fujita; Yoshiki Nakamura; Yasutake Saeki; Satoshi Okumura
PLOS ONE, Jun. 2015, 10(6)

心肥大と心不全
石川義弘; 藤田孝之; 梅村将就; 横山詩子
日本病態生理学会雑誌, 20 May 2015, 24(1):28 - 38

Oscillation of cAMP and Ca2+ in cardiac myocytes: a systems biology approach
Takehisa Kamide; Satoshi Okumura; Samik Ghosh; Yoko Shinoda; Yasumasa Mototani; Yoshiki Ohnuki; Huiling Jin; Wenqian Cai; Kenji Suita; Itaru Sato; Masanari Umemura; Takayuki Fujita; Utako Yokoyama; Motohiko Sato; Kazuharu Furutani; Hiroaki Kitano; Yoshihiro Ishikawa
JOURNAL OF PHYSIOLOGICAL SCIENCES, Mar. 2015, 65(2):195 - 200

Coupling of β1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes
Takashi Tsunematsu; Satoshi Okumura; Yasumasa Mototani; Yoshiki Ohnuki; Huiling Jin; Wenqian Cai; Kenji Suita; Itaru Sato; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Takayuki Fujita; Yoshihiro Ishikawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2015, 458(3):531 - 535

Role of cyclic AMP sensor Epac1 in masseter muscle hypertrophy and myosin heavy chain transition induced by β2-adrenoceptor stimulation
Yoshiki Ohnuki; Daisuke Umeki; Yasumasa Mototani; Huiling Jin; Wenqian Cai; Kouichi Shiozawa; Kenji Suita; Yasutake Saeki; Takayuki Fujita; Yoshihiro Ishikawa; Satoshi Okumura
JOURNAL OF PHYSIOLOGY-LONDON, Dec. 2014, 592(24):5461 - 5475

Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses
Satoshi Okumura; Takayuki Fujita; Wenqian Cai; Meihua Jin; Iyuki Namekata; Yasumasa Mototani; Huiling Jin; Yoshiki Ohnuki; Yayoi Tsuneoka; Reiko Kurotani; Kenji Suita; Yuko Kawakami; Shogo Hamaguchi; Takaya Abe; Hiroshi Kiyonari; Takashi Tsunematsu; Yunzhe Bai; Sayaka Suzuki; Yuko Hidaka; Masanari Umemura; Yasuhiro Ichikawa; Utako Yokoyama; Motohiko Sato; Fumio Ishikawa; Hiroko Izumi-Nakaseko; Satomi Adachi-Akahane; Hikaru Tanaka; Yoshihiro Ishikawa
JOURNAL OF CLINICAL INVESTIGATION, Jun. 2014, 124(6):2785 - 2801

Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells
Itaru Sato; Masanari Umemura; Kenji Mitsudo; Mitomu Kioi; Hideyuki Nakashima; Toshinori Iwai; Xianfeng Feng; Kayoko Oda; Akiyoshi Miyajima; Ayako Makino; Maki Iwai; Takayuki Fujita; Utako Yokoyama; Satoshi Okumura; Motohiko Sato; Haruki Eguchi; Iwai Tohnai; Yoshihiro Ishikawa
JOURNAL OF PHYSIOLOGICAL SCIENCES, May 2014, 64(3):177 - 183

Three-dimensional multilayers of smooth muscle cells as a new experimental model for vascular elastic fiber formation studies
Ryo Ishiwata; Utako Yokoyama; Michiya Matsusaki; Yoshiya Asano; Koji Kadowaki; Yasuhiro Ichikawa; Masanari Umemura; Takayuki Fujita; Susumu Minamisawa; Hiroshi Shimoda; Mitsuru Akashi; Yoshihiro Ishikawa
ATHEROSCLEROSIS, Apr. 2014, 233(2):590 - 600

Protection of Cardiomyocytes from the Hypoxia-Mediated Injury by a Peptide Targeting the Activator of G-Protein Signaling 8
Motohiko Sato; Masahiro Hiraoka; Hiroko Suzuki; Miho Sakima; Abdullah Al Mamun; Yukiko Yamane; Takayuki Fujita; Utako Yokoyama; Satoshi Okumura; Yoshihiro Ishikawa
PLOS ONE, Mar. 2014, 9(3)

Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration
Masanari Umemura; Erdene Baljinnyam; Stefan Feske; Mariana S. De Lorenzo; Lai-Hua Xie; Xianfeng Feng; Kayoko Oda; Ayako Makino; Takayuki Fujita; Utako Yokoyama; Mizuka Iwatsubo; Suzie Chen; James S. Goydos; Yoshihiro Ishikawa; Kousaku Iwatsubo
PLOS ONE, Feb. 2014, 9(2)

Pharmacological inhibition of STAT 3 protect heart from lipopolysaccharide-induced cardiac dysfunction through the inhibition of Jak2/STAT3/iNOS signaling
Jin Huiling; Satoshi Okumura; Jin Meihua; Cai Wenqian; Kenji Suita; Takashi Tsunematsu; Bai Yunzhe; Takayuki Fujita; Yoshihiro Ishikawa
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, 63:S179 - S179

TCTP/Fortilin regulates survival of carcinoma cells and cardiomyocytes
Takayuki Fujita; Wenqian Cai; Yuko Hidaka; Huiling Jin; Meihua Jin; Kenji Suita; Yoshihiro Ishikawa
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, 63:S76 - S76

Epac1 pathway plays an important role for the development of heart failure through the activation of PKA
Cai Wenqian; Satoshi Okumura; Takayuki Fujita; Jin Meihua; Kenji Suita; Jin Huiling; Yuko Hidaka; Yoshihiro Ishikawa
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, 63:S180 - S180

Vidarabine, an anti-herpesvirus agent, prevents atrial fibrillation in mice
Kenji Suite; Cai Wenqian; Jin Huiling; Jin Meihua; Takayuki Fujita; Satoshi Okumura; Yoshihiro Ishikawa
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, 63:S120 - S120

The function of Store-operated Ca2+ entry(SOCE)in melanoma
Masanari Umemura; Takayuki Fujita; Utako Yokoyama; Yoshihiro Ishikawa; Kousaku Iwatsubo
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, 63:S74 - S74

Disruption of Epaci Decreases Phosphorylation of Phospholamban and Protects the Heart Against Stresses
Satoshi Okumura; Meihua Jin; Yoshiki Ohnuki; Iyuki Namekata; Reiko Kurotani; Takayuki Fujita; Hui-Ling Jin; Weniqian Cai; Yunzhe Bai; Kenji Suita; Takashi Tsunematsu; Hikaru Tanaka; Yoshihiro Ishikawa
CIRCULATION, Nov. 2012, 126(21)

Stimulation of thromboxane A(2) receptor induced the constriction and remodeling of the ductus arteriosus in the rat
Tomohiro Yokota; Takashi Aida; Ryosuke Shiraishi; Yasuhiro Ichikawa; Takayuki Fujita; Utako Yokoyama
FASEB JOURNAL, Apr. 2012, 26

Apoptosis in Heart Failure: The role of the β-adrenergic receptor-mediated signaling pathway and p53-mediated signaling pathway in the apoptosis of cardiomyocytes
Takayuki Fujita; Yoshihiro Ishikawa
CIRCULATION JOURNAL, Aug. 2011, 75(8):1811 - 1818

高リスク心疾患に対する栄養・加齢・幹細胞の炎症への影響と組織再生能評価
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory)
Yokohama City University
09 Jul. 2021 - 31 Mar. 2024

高リスク心筋梗塞に対する運動介入効果による加齢への影響と組織再生能評価
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory)
Yokohama City University
29 Jun. 2018 - 31 Mar. 2023

交感神経による有害作用の選択的遮断等による，安全な心疾患治療の確立についての検討
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
01 Apr. 2019 - 31 Mar. 2022

循環制御におけるホメオスタシスの破綻予測
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Yokohama City University
18 Jul. 2018 - 31 Mar. 2021

新規cAMP標的分子“EPAC”の動脈硬化発症における役割
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Yokohama City University
01 Apr. 2016 - 31 Mar. 2019

新規cAMP標的分子 EPAC の高血圧発症における役割
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Yokohama City University
01 Apr. 2013 - 31 Mar. 2016

自律神経による心機能制御の分子メカニズム
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Yokohama City University
01 Apr. 2012 - 31 Mar. 2016

心筋細胞シグナルパスウェイ制御機構と神経性調節の統合的解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Yokohama City University
01 Apr. 2010 - 31 Mar. 2015

新たなp53機能制御タンパク"Fortilin"を介した心疾患制御の可能性
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B)
Yokohama City University
2009 - 2011