Sep. 2023
Traditional and Kampo medicine誌, Top Cited Award 2022 In Traditional and Kampo medicine
Effects of two kinds of Kampo-hozai, ninjinyoeito and kamikihito, on mental disorder-like behaviors in senescence-accelerated mouse- prone 8 mice
Marika Hirata, Chise Taniguchi, Takuya Watanabe, Toru Horikawa, Yufuko Akizuki, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki

04 Sep. 2021
和漢医薬学会, 和漢医薬学会 学術貢献賞
易怒性・攻撃性に対して抑制効果を示す漢方薬の作用機序探索, Japan society
渡辺拓也

Aug. 2018
公益社団法人日本薬学会薬理系薬学部会, 生体機能と創薬シンポジウム優秀発表賞
発達障害で認められる社会性行動障害の治療を目的とした漢方薬の探索, Japan society
渡辺拓也

Jan. 2012
上原記念生命科学財団, 海外留学助成ポストドクトラルフェローシップ
Publisher

Ninjinyoeito ameliorates anorexia and changes in peptide YY and ghrelin levels of cisplatin-treated mice
Akinobu Hatae; Takuya Watanabe; Chise Taniguchi; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Neuropeptides, Oct. 2024, 107:102464 - 102464, Refereed
Corresponding

精神安定作用を示す加味逍遙散と加味帰脾湯の作用点の違い
渡辺 拓也
ファルマシア, Aug. 2024, 60(8):797 - 797
Lead

Location analysis of presynaptically active and silent synapses in single-cultured hippocampal neurons
Otoya Kitaoka; Kohei Oyabu; Kaori Kubota; Takuya Watanabe; Satoru Kondo; Teppei Matsui; Shutaro Katsurabayashi; Katsunori Iwasaki
13 Dec. 2023

The Effects of Ninjinyoeito on Impaired Spatial Memory and Prefrontal Cortical Synaptic Plasticity through α-Amino-3-hydroxy-5-4-isoxazole Propionic Acid Receptor Subunit in a Rat Model with Cerebral Ischemia and β-Amyloid Injection
Masaki Nagao; Akinobu Hatae; Kazuma Mine; Soichiro Tsutsumi; Hiroya Omori; Marika Hirata; Maaya Arimatsu; Chise Taniguchi; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Evidence-Based Complementary and Alternative Medicine, 30 Sep. 2023, 2023:1 - 10

Ninjinyoeito Prevents Onset of Depression-Like Behavior and Reduces Hippocampal iNOS Expression in Senescence-Accelerated Mouse Prone 8 Mice
Chise Taniguchi; Takuya Watanabe; Marika Hirata; Akinobu Hatae; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Evidence-Based Complementary and Alternative Medicine, 09 Aug. 2023, 2023:1 - 9, Refereed
Corresponding

Astrocyte Ca2+ signaling is facilitated in Scn1a+/− mouse model of Dravet syndrome
Kouya Uchino; Yasuyoshi Tanaka; Wakana Ikezawa; Masanobu Deshimaru; Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Katsunori Iwasaki; Shinichi Hirose
Biochemical and Biophysical Research Communications, Feb. 2023, 643:169 - 174

Kamishoyosan Alleviates Anxiety-like Behavior in a Premenstrual Syndrome Rat Model
Hikari Iba-Tanaka; Takuya Watanabe; Kyoka Harada; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Evidence-Based Complementary and Alternative Medicine, 14 Oct. 2022, 2022:1 - 8, Refereed

Establishment of autaptic culture with human induced pluripotent stem cell-derived astrocytes
Uchino K; Tanaka Y; Kawaguchi S; Kubota K; Watanabe T; Katsurabayashi S; Hirose S; Iwasaki K
iScience, Aug. 2022, 25(8):104762 - 104762, Refereed

Ninjinyoeito reduces β‐amyloid_25–35‐induced axon damage via nerve growth factor
Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Katsunori Iwasaki
Traditional & Kampo Medicine, 21 Jun. 2022, 9(2):89 - 97

Sansoninto attenuates aggressive behavior and increases levels of homovanillic acid, a dopamine metabolite, in social isolation-reared mice
Takuya Watanabe; Hikari Iba; Hiroshi Moriyama; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of Traditional and Complementary Medicine, May 2022, 12(3):243 - 249, Refereed
Lead

Ninjinyoeito exerts an antidepressant-like effect by enhancing the central noradrenergic system
Soichiro Tsutsumi; Takuya Watanabe; Akinobu Hatae; Marika Hirata; Hiroya Omori; Chise Taniguchi; Masaki Nagao; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Traditional & Kampo Medicine, 03 Apr. 2022, 9(1):25 - 31, Refereed
Corresponding

Kamishoyosan potentiates pentobarbital-induced sleep in socially isolated, ovariectomized mice
Nobuaki Egashira; Yu Goto; Hikari Iba; Rikako Kawanaka; Ryota Takahashi; Chise Taniguchi; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of Ethnopharmacology, 05 Dec. 2021, 281:114585 - 114585, Refereed

Behavioral profile in a Dctn1G71A knock-in mouse model of Perry disease
Manami Deshimaru; Takayasu Mishima; Takuya Watanabe; Kaori Kubota; Mana Hosoi; Mariko Kinoshita-Kawada; Junichi Yuasa-Kawada; Maiko Ikeda; Masayoshi Mori; Yusuke Murata; Takaya Abe; Munechika Enjoji; Hiroshi Kiyonari; Shohta Kodama; Shinsuke Fujioka; Katsunori Iwasaki; Yoshio Tsuboi
Neuroscience Letters, 01 Nov. 2021, 764:136234 - 136234, Refereed

Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats
Nobuaki Egashira; Yu Goto; Ryota Takahashi; Hikari Iba; Shota Yamamoto; Takuya Watanabe; Kaori Kubota; Takehiro Kawashiri; Chise Taniguchi; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of Pharmacological Sciences, Sep. 2021, 147(1):114 - 117, Refereed

The novel mitochondria activator, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), promotes the development of hippocampal neuronal morphology
Shutaro Katsurabayashi; Kohei Oyabu; Kaori Kubota; Takuya Watanabe; Tomohisa Nagamatsu; Norio Akaike; Katsunori Iwasaki
Biochemical and Biophysical Research Communications, 30 Jun. 2021, 560:146 - 151, Refereed

Effects of two kinds of Kampo-hozai, ninjinyoeito and kamikihito, on mental disorder-like behaviors in senescence-accelerated mouse-prone 8 mice
Marika Hirata; Chise Taniguchi; Takuya Watanabe; Toru Horikawa; Yufuko Akizuki; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Traditional & Kampo Medicine, 15 Jun. 2021, 8(2):176 - 180, Refereed
Corresponding

Inhibitory synaptic transmission is impaired at higher extracellular Ca 2+ concentrations in Scn1a +/- mouse model of Dravet syndrome
Kouya Uchino; Hiroyuki Kawano; Yasuyoshi Tanaka; Yuna Adaniya; Ai Asahara; Masanobu Deshimaru; Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Katsunori Iwasaki; Shinichi Hirose
Scientific reports, 20 May 2021, 11(1):10634 - 10634, Refereed

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
Manami Deshimaru; Mariko Kinoshita-Kawada; Kaori Kubota; Takuya Watanabe; Yasuyoshi Tanaka; Saito Hirano; Fumiyoshi Ishidate; Masaki Hiramoto; Mitsuru Ishikawa; Yoshinari Uehara; Hideyuki Okano; Shinichi Hirose; Shinsuke Fujioka; Katsunori Iwasaki; Junichi Yuasa-Kawada; Takayasu Mishima; Yoshio Tsubo
International Journal of Molecular Sciences, 13 Apr. 2021, 22(8):3985, Refereed

マウスのガラス玉覆い隠し行動に対するメマンチン塩酸塩OD錠「ニプロ」の抑制効果
長尾昌紀; 射場日佳里; 弟子丸眞実; 内野鉱也; 平田茉莉花; 堤宗一朗; 渡辺拓也; 岩崎克典
医学と薬学, Feb. 2021, 78(2):143 - 148, Refereed

Valproic acid-exposed astrocytes impair inhibitory synapse formation and function
Kotomi Takeda; Takuya Watanabe; Kohei Oyabu; Shuntaro Tsukamoto; Yuki Oba; Takafumi Nakano; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Scientific reports, 08 Jan. 2021, 11(1):23 - 23, Refereed
Corresponding

A Japanese herbal medicine attenuates anxiety-like behavior through GABA A receptor and brain-derived neurotrophic factor expression in a rat model of premenstrual syndrome
Hikari Iba; Takuya Watanabe; Saori Motomura; Kyoka Harada; Haruka Uesugi; Takenori Shibahara; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of pharmacological sciences, Jan. 2021, 145(1):140 - 149, Refereed
Corresponding

Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus
Motokazu Uchigashima; Kohtarou Konno; Emily Demchak; Amy Cheung; Takuya Watanabe; David G Keener; Manabu Abe; Timmy Le; Kenji Sakimura; Toshikuni Sasaoka; Takeshi Uemura; Yuka Imamura Kawasawa; Masahiko Watanabe; Kensuke Futai
Elife, 23 Dec. 2020, 9:e59545, Refereed

Presynaptically silent synapses are modulated by the density of surrounding astrocytes
Kohei Oyabu; Kotomi Takeda; Hiroyuki Kawano; Kaori Kubota; Takuya Watanabe; N Charles Harata; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of pharmacological sciences, Oct. 2020, 144(2):76 - 82, Refereed

Neuroligin3 splice isoforms shape inhibitory synaptic function in the mouse hippocampus.
Uchigashima, M; Leung, M; Watanabe, T; Cheung, A; Le, T; Pallat, S; Dinis, A; Watanabe, M; Kawasawa, Y. I; Futai, K
The Journal of biological chemistry, 19 Jun. 2020, 295(25):8589 - 8595, Refereed

Oligodendrocytes upregulate blood-brain barrier function through mechanisms other than the PDGF-BB/PDGFRα pathway in the barrier-tightening effect of oligodendrocyte progenitor cells.
Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Takuro Iwao; Atsushi Yamauchi; Yasufumi Kataoka
Neuroscience Letters, Oct. 2019, 715:134594 - 134594

Effect of yokukansan and yokukansankachimpihange on aggressive behavior, 5-HT receptors and arginine vasopressin expression in social isolation-reared mice
Iba H; Watanabe T; Matsuzawa K; Saimiya M; Tanaka M; Moriyama H; Kubota K; Katsurabayashi S; Iwasaki K
Biological and Pharmaceutical Bulletin, Sep. 2019, 42(12):2009 - 2015, Refereed
Corresponding

Hippocampal neurons in direct contact with astrocytes exposed to amyloid β25-35 exhibit reduced excitatory synaptic transmission
Kohei Oyabu; Hiroki Kiyota; Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Katsunori Iwasaki
IBRO Reports, Jul. 2019, 7:34 - 41, Refereed

Effect of Lactobacillus paracasei A221‐fermented ginseng on impaired spatial memory in a rat model with cerebral ischemia and β‐amyloid injection
Masaki Nagao; Satoshi Yamano; Naoki Imagawa; Kentaro Igami; Toshitsugu Miyazaki; Hisatomi Ito; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Traditional & Kampo Medicine, May 2019, 6(2):96 - 104, Refereed

Extract of Yokukansan improves anxiety-like behavior and increases serum brain-derived neurotrophic factor in rats with cerebral ischemia combined with amyloid-β42 peptide
Ai Nogami-Hara; Kaori Kubota; Kotaro Takasaki; Takuya Watanabe; Nobuaki Egahira; Hikari Iba; Risako Fujikawa; Shutaro Katsurabayashi; Funda Bolukbasi Hatip; Izzettin Hatip-Al-Khatib; Katsunori Iwasaki
Journal of Traditional Chinese Medicine, 15 Feb. 2019, 39(1):50 - 58, Refereed

不眠に処方される漢方薬の作用機序
岩崎克典; 長尾昌紀; 森山博史; 渡辺拓也
Progress in Medicine, Oct. 2018, 38(10):13 - 19

The Japanese Angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia
Ai Nogami-Hara; Masaki Nagao; Kotaro Takasaki; Nobuaki Egashira; Risako Fujikawa; Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Funda Bolukbasi Hatip; Izzettin Hatip-Al-Khatib; Katsunori Iwasaki
Journal of Ethnopharmacology, 25 Mar. 2018, 214:190 - 196, Refereed

Behavioral defects in a DCTN1G71A transgenic mouse model of Perry syndrome
Takayasu Mishima; Manami Deshimaru; Takuya Watanabe; Kaori Kubota; Mariko Kinoshita-Kawada; Junichi Yuasa-Kawada; Kotaro Takasaki; Yoshinari Uehara; Shozo Jinno; Katsunori Iwasaki; Yoshio Tsuboi
Neuroscience Letters, Feb. 2018, 666:98 - 103

The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D2 and 5-HT2A receptors: Implications for obsessive–compulsive disorder
Nobuaki Egashira; Naoki Kubota; Yu Goto; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
Pharmacology Biochemistry and Behavior, 01 Feb. 2018, 165:9 - 13, Refereed

Astrocytes with previous chronic exposure to amyloid β-peptide fragment 1-40 suppress excitatory synaptic transmission.
Hiroyuki Kawano; Kohei Oyabu; Hideaki Yamamoto; Kei Eto; Yuna Adaniya; Kaori Kubota; Takuya Watanabe; Ayumi Hirano-Iwata; Junichi Nabekura; Shutaro Katsurabayashi; Katsunori Iwasaki
Journal of neurochemistry, Dec. 2017, 143(6):624 - 634, Refereed

The Traditional Japanese Herbal Medicine Hachimijiogan Elicits Neurite Outgrowth Effects in PC12 Cells and Improves Cognitive in AD Model Rats via Phosphorylation of CREB
Kaori Kubota; Haruka Fukue; Hitomi Sato; Kana Hashimoto; Aya Fujikane; Hiroshi Moriyama; Takuya Watanabe; Shutaro Katsurabayashi; Mosaburo Kainuma; Katsunori Iwasaki
FRONTIERS IN PHARMACOLOGY, Nov. 2017, 8

アリピプラゾール錠・OD錠・散・内服液「ニプロ」のマウスを用いた抗精神病効果の検討
長尾昌紀; 森山博史; 大藪康平; 安谷屋友菜; 胸元 芳; 渡辺拓也; 岩崎克典
新薬と臨床, Jun. 2017, 66(5):611 - 620, Refereed

Effect of hachimijiogan on memory impairment induced by beta-amyloid combined with cerebral ischemia in rats.
Hiroshi Moriyama; Takayasu Mishima; Mosaburo Kainuma; Takuya Watanabe; Masaki Nagao; Kotaro Takasaki; Kaori Kubota; Shutaro Katsurabayashi; Yoshio Tsuboi; Katsunori Iwasaki
Traditional & Kampo Medicine, 03 Apr. 2017, 4(1):51 - 54, Refereed

Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer's disease rat model
Hiroshi Moriyama; Takuya Watanabe; Kotaro Takasaki; Masaki Nagao; Kaori Kubota; Shutaro Katsurabayashi; Nobuaki Egashira; Katsunori I
Traditional & Kampo Medicine, 03 Apr. 2017, 4(1):38 - 45, Refereed

Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats
Nobuaki Egashira; Hikari Iba; Haruna Kuwano; Rikako Kawanaka; Masaki Nagao; Hiroshi Moriyama; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki
JOURNAL OF PHARMACOLOGICAL SCIENCES, Aug. 2016, 131(4):279 - 283, Refereed

神経栄養因子の補充療法に替わる抑肝散による認知症治療法の構築
Kaori Kubota; Takuya Watanabe; Shutaro Katsurabayashi; Katsunori Iwasaki
BIO Clinica, Apr. 2016, 31(4):87 - 92

アルツハイマー型認知症モデルラットの空間認知障害に対するドネペジルと抑肝散の併用効果
角田菜緒; 長尾昌紀; 森山博史; 呼和哈斯; 古賀冴華; 窪田香織; 渡辺拓也; 桂林秀太郎; 岩崎克典
臨牀と研究, 2016, 93(12):1659 - 1660

Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture
Marta Esteves da Silva; Max Adrian; Philipp Schatzle; Joanna Lipka; Takuya Watanabe; Sukhee Cho; Kensuke Futai; Corette J. Wierenga; Lukas C. Kapitein; Casper C. Hoogenraad
CELL REPORTS, Nov. 2015, 13(5):933 - 943, Refereed

Nifedipine Prevents Sodium Caprate-Induced Barrier Dysfunction in Human Epidermal Keratinocyte Cultures
Yoshihiro Uchino; Junichi Matsumoto; Takuya Watanabe; Masato Hamabashiri; Takashi Tsuchiya; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2015, 38(6):926 - 929, Refereed

Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons
Wenjie Mao; Takuya Watanabe; Sukhee Cho; Jeffrey L. Frost; Tina Truong; Xiaohu Zhao; Kensuke Futai
EUROPEAN JOURNAL OF NEUROSCIENCE, Apr. 2015, 41(8):1025 - 1035, Refereed

Tumor necrosis factor-α reduces beta-amyloid accumulation primarily by lowering cellular prion protein levels in a brain endothelial cell line
Yuki Yasutaka; Takuya Watanabe; Akio Nakashima; Junichi Matsumoto; Koujiro Futagami; Atsushi Yamauchi; Yasufumi Kataoka
FEBS LETTERS, Jan. 2015, 589(2):263 - 268, Refereed

Injection of specific amyloid-beta oligomers (beta(1-40):beta(1-42)=10:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis
Mehmet Bulent Ozdemir; Cagdas Erdogan; Katsunori Iwasaki; Takuya Watanabe; Shin Ishikane; Michihiro Fujiwara
NEUROLOGICAL RESEARCH, Oct. 2013, 35(8):798 - 803, Refereed

Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden
Takuya Watanabe; Kotaro Takasaki; Norito Yamagata; Michihiro Fujiwara; Katsunori Iwasaki
Neuroscience Letters, 01 Mar. 2013, 536:74 - 79, Refereed

Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4
WATANABE Takuya; DOHGU Shinya; TAKATA Fuyuko; NAKASHIMA Akio; FUTAGAMI Kojiro; YAMAUCHI Atsushi; KATAOKA Yasufumi
Biological & Pharmaceutical Bulletin, Jan. 2013, 36(3):492 - 495, Refereed

Atorvastatin stimulates neuroblastoma cells to induce neurite outgrowth by increasing cellular prion protein expression
WATANABE Takuya; NAKASHIMA Akio; YAMAUCHI Atsushi; KATAOKA Yasufumi
Neuroscience letters, 07 Dec. 2012, 531(2):114 - 119, Refereed

Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis
Tsuyoshi Nishioku; Shinya Dohgu; Mitsuhisa Koga; Takashi Machida; Takuya Watanabe; Teppei Miura; Kousuke Tsumagari; Mariko Terasawa; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF INFLAMMATION-LONDON, Nov. 2012, 9(1):44, Refereed

Cholinergic Involvement and Synaptic Dynamin 1 Expression in Yokukansan-mediated Improvement of Spatial Memory in a Rat Model of Early Alzheimer's Disease.
Naoki Uchida; Kotaro Takasaki; Yuri Sakata; Ai Nogami; Hiroshi Oishi; Takuya Watanabe; Taro Shindo; Nobuaki Egashira; Kaori Kubota; Shutaro Katsurabayashi; Kenichi Mishima; Michihiro Fujiwara; Ryoji Nishimura; Katsunori Iwasaki
Phytotherapy research, Aug. 2012, 27(7):966 - 972

Involvement of the cellular prion protein in the migration of brain microvascular endothelial cells
Takuya Watanabe; Yuki Yasutaka; Tsuyoshi Nishioku; Sae Kusakabe; Koujiro Futagami; Atsushi Yamauchi; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Jun. 2011, 496(2):121 - 124, Refereed

Partial hepatectomy aggravates cyclosporin A-induced neurotoxicity by lowering the function of the blood-brain barrier in mice
Atsushi Yamauchi; Shinya Dohgu; Fuyuko Takata; Takuya Watanabe; Tsuyoshi Nishioku; Junich Matsumoto; Yuka Ohkubo; Hideki Shuto; Yasufumi Kataoka
LIFE SCIENCES, Mar. 2011, 88(11-12):529 - 534, Refereed

Disruption of the blood-brain barrier in collagen-induced arthritic mice
Tsuyoshi Nishioku; Atsushi Yamauchi; Fuyuko Takata; Takuya Watanabe; Koki Furusho; Hideki Shuto; Shinya Dohgu; Yasufumi Kataoka
NEUROSCIENCE LETTERS, Oct. 2010, 482(3):208 - 211, Refereed

Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1.
Dohgu S; Takata F; Matsumoto J; Oda M; Harada E; Watanabe T; Nishioku T; Shuto H; Yamauchi A; Kataoka Y
Microvasc Res., Oct. 2010, 81(1):103 - 7, Refereed

Cyclosporin A induces hyperpermeability of the blood-brain barrier by inhibiting autocrine adrenomedullin-mediated up-regulation of endothelial barrier function
Shinya Dohgu; Noriko Sumi; Tsuyoshi Nishioku; Fuyuko Takata; Takuya Watanabe; Mikihiko Naito; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
EUROPEAN JOURNAL OF PHARMACOLOGY, Oct. 2010, 644(1-3):5 - 9, Refereed

Development of an Ultra-Rapid Diagnostic Method Based on Heart-Type Fatty Acid Binding Protein Levels in the CSF of CJD Patients
Yuki Matsui; Katsuya Satoh; Kazuo Mutsukura; Takuya Watanabe; Noriyuki Nishida; Hideo Matsuda; Masaichi Sugino; Susumu Shirabe; Katsumi Eguchi; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, Oct. 2010, 30(7):991 - 999, Refereed

Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
Watanabe T; Iwasaki K; Takasaki K; Yamagata N; Fujino M; Nogami A; Ii M; Katsurabayashi S; Mishima K; Fujiwara M
J Neurosci Res., Jun. 2010, 88(9):1908 - 17, Refereed

Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood-Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia
Noriko Sumi; Tsuyoshi Nishioku; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Hideki Shuto; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, Mar. 2010, 30(2):247 - 253, Refereed

Disruption of the blood-brain barrier in collagen-induced arthritic mice
Koki Furusho; Tsuyoshi Nishioku; Teppei Miura; Ayano Tomita; Shinya Dohgu; Fuyuko Takata; Takuya Watanabe; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112(3):108P - 108P, Refereed

Therapeutic Time Window of Cannabidiol Treatment on Delayed Ischemic Damage via High-Mobility Group Box1-Inhibiting Mechanism
Kazuhide Hayakawa; Keiichi Irie; Kazunori Sano; Takuya Watanabe; Sei Higuchi; Makiko Enoki; Takafumi Nakano; Kazuhiko Harada; Shin Ishikane; Tomoaki Ikeda; Masayuki Fujioka; Kensuke Orito; Katsunori Iwasaki; Kenichi Mishima; Michihiro Fujiwara
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2009, 32(9):1538 - 1544, Refereed

Decreased acetylcholine release as correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease
Takuya Watanabe; Norito Yamagata; Kotaro Takasaki; Kazunori Sano; Kazuhide Hayakawa; Shutaro Katsurabayashi; Nobuaki Egashira; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
BRAIN RESEARCH, Jan. 2009, 1249:222 - 228, Refereed

Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats
Takuy Watanabe; Katsunori Iwasaki; Shin Ishikane; Tetsuya Naitou; Yoshitaka Yoshimitsu; Norito Yamagata; Mehmeto Biflent Ozdemir; Kotaro Takasaki; Nobuaki Egashira; Kenichi Mishinia; Michihiro Fujiwara
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jan. 2008, 106(1):84 - 91, Refereed

Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats
Katsunori Iwasaki; Nobuaki Egashira; Izzettin Hatip-Al-Khatib; Yuki Akiyoshi; Takashi Arai; Yuki Takayaki; Takuya Watanabe; Kenichi Mishima; Michihiro Fujiwara
BRAIN RESEARCH, Jun. 2006, 1097(1):216 - 223, Refereed

Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice
N Egashira; K Iwasaki; A Takashima; T Watanabe; H Kawabe; T Matsuda; K Mishima; S Chidori; R Nishimura; M Fujiwara
BRAIN RESEARCH, Oct. 2005, 1059(1):7 - 12

老化促進モデルSAMP8マウスの活動量と脳乳酸の機能に関する基礎研究
谷口知世; 渡辺拓也; 平田茉莉花; 波多江旺信; 井手菜々子; 窪田香織; 桂林秀太郎; 岩崎克典
日本薬理学雑誌, 2023, 158(Supplement)

シスプラチン誘発マウス疲労様行動に対する人参養栄湯の効果
波多江旺信; 渡辺拓也; 平田茉莉花; 谷口知世; 延原奈美; 窪田香織; 桂林秀太郎; 岩崎克典
日本薬理学雑誌, 2023, 158(Supplement)

老化促進マウスSAMP8の悪臭回避行動低下と嗅覚経路障害に関する研究
平田茉莉花; 渡辺拓也; 渡辺拓也; 村田雄介; 村田雄介; 谷口知世; 波多江旺信; 宮路えりか; 山下真由; 窪田香織; 窪田香織; 桂林秀太郎; 岩崎克典; 岩崎克典
日本薬学会年会要旨集(Web), 2022, 142nd

老化促進モデルSAMP8マウスのうつ様行動とiNOS発現に対する人参養栄湯の効果
谷口知世; 渡辺拓也; 渡辺拓也; 平田茉莉花; 石橋裕基; 柿西晴夏; 窪田香織; 窪田香織; 桂林秀太郎; 岩崎克典; 岩崎克典
日本薬理学雑誌, 2022, 157(Supplement)

老化促進マウスSAMP8の嗅覚障害に対する人参養栄湯の効果
平田茉莉花; 渡辺拓也; 渡辺拓也; 谷口知世; 波多江旺信; 宮路えりか; 山下真由; 窪田香織; 窪田香織; 桂林秀太郎; 岩崎克典; 岩崎克典
日本薬学会九州支部大会講演要旨集, 2021, 38th

卵巣摘出ラットの不安様行動に対する加味逍遥散および柴胡加竜骨牡蛎湯の改善作用
谷口知世; 江頭伸昭; 射場日佳里; 川中理香子; 長尾昌紀; 渡辺拓也; 渡辺拓也; 窪田香織; 窪田香織; 桂林秀太郎; 岩崎克典; 岩崎克典
和漢医薬学会学術大会要旨集, 2018, 35th

更年期障害モデルラットにおける不安行動に対する加味逍遥散および柴胡加竜骨牡蛎湯の作用
谷口知世; 江頭伸昭; 射場日佳里; 川中理香子; 長尾昌紀; 渡辺拓也; 渡辺拓也; 窪田香織; 窪田香織; 桂林秀太郎; 岩崎克典; 岩崎克典
和漢医薬学会学術大会要旨集, 2017, 34th

Brain pericytes facilitate insulin-induced phosphorylation of Akt in the hypothalamic neuronal cells
Hiroyuki Takahashi; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Atsushi Yamauchi; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:189P - 189P

老化促進モデルマウスの行動変容に対する人参養栄湯の効果～フレイル予防を目指して～
渡辺拓也
第40回和漢医薬学会学術大会, 27 Aug. 2023

バルプロ酸暴露アストロサイトのシナプス形成・伝達に対する影響
渡辺 拓也; 武田 琴水; 大藪 康平; 内野 鉱也; 窪田 香織; 桂林 秀太郎; 岩崎 克典
日本薬学会第１４２年会, 27 Mar. 2022, 日本薬学会

易怒性・攻撃性に対して抑制効果を示す漢方薬の作用機序探索
第３８回和漢医薬学会学術大会 学術貢献賞受賞講演, 04 Sep. 2021, 和漢医薬学会

発達障害で認められる社会性行動障害の治療を目的とした漢方薬の探索
渡辺拓也; 射場日佳里; 松澤香奈絵; 川井 優; 才宮万季; 冨高真弘; 入佐紘司; 窪田香織; 桂林秀太郎; 岩崎克典
生体機能と創薬シンポジウム２０１８, 24 Aug. 2018, 公益社団法人日本薬学会薬理系薬学部会

アルツハイマー病モデル動物の空間記憶障害における八味地黄丸の効果
渡辺拓也; 岩崎克典
医療薬学フォーラム２０１７, 02 Jul. 2017, 公益社団法人日本薬学会医療薬科学部会

日本薬理学会

日本小児科学会

Society for Neuroscience

日本神経精神薬理学会

日本薬学会

和漢医薬学会

高齢者疲労感の病態解明を目的とした漢方「補剤」の作用機序研究
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
Apr. 2023 - Mar. 2026

アルツハイマー病の早期嗅覚障害への介入が認知機能障害発症に与える影響の基礎研究
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
Apr. 2023 - Mar. 2026

アンドロゲンシグナルから捉えるCOPD病態の解析と治療薬の探索
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
Apr. 2022 - Mar. 2025

自閉症モデルマウス由来アストロサイトによる興奮性シナプス伝達増強の分子機序解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
Apr. 2020 - Mar. 2023

がん関連疲労に対する漢方補剤の有効性に関する基礎研究
公益財団法人 臨床研究奨励基金, コメディカル臨床研究助成, コメディカル臨床研究助成
Nov. 2021 - Oct. 2022

胎児期バルプロ酸暴露誘発自閉症スペクトラム障害におけるアストロサイト分泌因子異常
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
Apr. 2017 - Mar. 2020

尿酸-P2X7受容体-GSK3β経路によるパーキンソン病の発症・進展制御機構
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
Oct. 2015 - Mar. 2018

自閉症病態解明を目的としたオリゴデンドロサイト前駆細胞のシナプス分子基盤解析
公益財団法人 臨床研究奨励基金, 研究助成寄附金
Oct. 2014 - Mar. 2016

P2X7受容体を介した尿酸のパーキンソン病発症・進展抑制効果
グラクソ・スミスクライン株式会社, GSKジャパン研究助成
Oct. 2014 - Mar. 2016

抑制性神経細胞特異的シナプス局在分子の同定と機能解析によるASD発症機序解明
公益財団法人小児医学研究振興財団, 研究助成金, 研究助成金
Mar. 2012 - Mar. 2013