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Last Updated :2025/01/05
Department of Phatmaceutics
Professor
Profile2008- Engaged in Studies on the Creation of Lead Compounds Toward Drug Discovery 1986- Engaged in research on Heterocyclic Enaminonitriles 2000- Engaged in research on Aromatic Nitro Compounds and Pyrazol-3-one Derivatives 2004-2005 Engaged in research on Dihydropyrazine Derivatives
Career
■ Career
- 01 Apr. 2013
Fukuoka University Professor - 01 Apr. 2008
福岡大学薬学部 准教授 - 01 Apr. 2007
福岡大学薬学部 講師 - 01 Apr. 1986
Research Associate, Faculty of Pharmaceutical Sciences, Fukuoka University
- 1986
Kyushu University, Graduate School, Division of Pharmaceutical Sciences, Organic Chemistry - 1984
Fukuoka University, Faculty of Pharmaceutical Science, 製薬化学科
Research activity information
■ Paper
■ Lectures, oral presentations, etc.
■ Affiliated academic society
■ Industrial Property Rights
- Applications of 4-alkynylated pyrazol-3-ones: Synthesis of pyrazol-4-yl furan- and/or thiophene-2-carboxylates
Takafumi Fujita; Fumi Okabe-Nakahara; Hiroshi Maruoka; Eiichi Masumoto
Synthetic Communications, 31 Jul. 2024, 54(16):1321 - 1331, Refereed - Spiro Heterocycles: Synthesis and Application of Spiro Pyrazol-3-one Derivatives
MASUMOTO Eiichi; MARUOKA Hiroshi
HETEROCYCLES, Apr. 2022, 104(4):623 - 653, Refereed - Synthesis of Benzimidazoles, Benzoxazoles and Benzothiazole by the Reaction of 2-Amino-4,5-dihydro-3-furancarbonitrile and o-Substituted Anilines in the Catalysis of Trimetylamine Hydrochloride
Okabe-NAKAHARA Fumi; NAGABUCHI Hayate; Masumoto Eiichi; MARUOKA Hiroshi
HETEROCYCLES, 02 Sep. 2021, 102(11):2207 - 2214, Refereed - Synthesis and Reaction of Novel Spiro Pyrazol-3-ones Containing Oxirane Moiety
NAGABUCHI Hayate; MASUMOTO Eiichi; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
HETEROCYCLES, Jul. 2021, 102(7):1354 - 1373, Refereed - Synthesis and Evaluation for Biological Activities of 2-Thio-Acylated Thiazoles Containing Pyrazole Moiety
MASUMOTO Eiichi; KASHIGE Nobuhiro; NAGABUCHI Hayate; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
HETEROCYCLES, 30 Jan. 2020, 98(12):1736 - 1746, Refereed - A Convenient Approach to the Synthesis of Novel Tricyclic Fused Furo[2,3-b]pyridine Derivatives
OKABE-NAKAHARA Fumi; NAGABUCHI Hayate; Masumoto Eiichi; MARUOKA Hiroshi; YAMAGATA Kenji
HETEROCYCLES, Jul. 2019, 98(7):966 - 976, Refereed - An Efficient Three-Component Synthesis of Novel Spiro[pyrazole-4,2'-quinazoline] Derivatives
NAGABUCHI Hayate; MASUMOTO Eiichi; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
HETEROCYCLES, Jun. 2019, 98(6):845 - 862, Refereed - Synthesis and DNA Cleavage Activity of Novel Spiro[cyclobutathiazole-4,4'-pyrazole] Derivatives
MASUMOTO Eiichi; NAGABUCHI Hayate; KASHIGE Nobuhiro; OKABE-NAKAHARA Fumi; MIAKE Fumio; YAMAGATA Kenji; MARUOKA Hiroshi
HETEROCYCLES, May 2019, 99(1):669 - 679, Refereed - Synthesis and DNA Cleavage Activity of Novel Spiro Pyrazol-3-ones Containing Isoxazoline Moiety
MASUMOTO Eiichi; SHIROUZU Emi; KASHIGE Nobuhiro; OKABE-NAKAHARA Fumi; MIAKE Fumio; YAMAGATA Kenji; MARUOKA Hiroshi
HETEROCYCLES, Jul. 2018, 96(7):1289 - 1300, Refereed - Erratum: Synthesis of novel angular and linear fused [5-6-5] heterocycles by the reaction of Methyl Cyano-(3-Cyano-4,5-Dihydro-2(3H)-Furanylidene) Acetate with hydrazines and dimethylformamide dimethyl acetal (Heterocycles (2018) 96 (664) DOI: 10.3987/COM-17-13861)
Fumi Okabe-Nakahara; Eiichi Masumoto; Hiroshi Maruoka; Kenji Yamagata
Heterocycles, 2018, 96(6):1169 - One-pot three-component synthesis of novel pyrazole-2,3-pyrroledicarboxylic acid 2,3-diesters
Emi Shirouzu; Eiichi Masumoto; Fumi Okabe-Nakahara; Kenji Yamagata; Hiroshi Maruoka
Heterocycles, 2018, 96(2):233 - 253, Refereed - Synthesis of novel angular and linear fused [5-6-5] heterocycles by the reaction of methyl cyano-(3-Cyano-4,5-dihydro-2(3H-furanylidene)acetate with hydrazines and dimethylformamide dimethyl acetal
Fumi Okabe-Nakahara; Eiichi Masumoto; Hiroshi Maruoka; Kenji Yamagata
Heterocycles, 2018, 96(4):664 - 676, Refereed - Amino Acid Metabolomics Using LC-MS/MS: Assessment of Cancer-Cell Resistance in a Simulated Tumor Microenvironment
Ryoko Tomita; Kenichiro Todoroki; Hiroshi Maruoka; Hideyuki Yoshida; Toshihiro Fujioka; Manabu Nakashima; Masatoshi Yamaguchi; Hitoshi Nohta
ANALYTICAL SCIENCES, Aug. 2016, 32(8):893 - 900, Refereed - SYNTHESIS AND DNA CLEAVAGE ACTIVITY OF FUNCTIONALIZED PYRAZOL-3-ONES CONTAINING OXIME ESTER
Eiichi Masumoto; Nobuhiro Kashige; Fumi Okabe; Fumio Miake; Kenji Yamagata; Hiroshi Maruoka
HETEROCYCLES, Jul. 2016, 92(7):1293 - 1306, Refereed - CHEMICAL REACTIVITY AND APPLICATION OF 4-ALKYLIDENE-3H-PYRAZOL-3-ONES: SYNTHESIS AND ANTIFUNGAL ACTIVITY OF POLYSUBSTITUTED PYRAZOLES
Hiroshi Maruoka; Masataka Hokao; Nobuhiro Kashige; Eiichi Masumoto; Fumi Okabe; Reiko Tanaka; Fumio Miake; Toshihiro Fujioka; Kenji Yamagata
HETEROCYCLES, Apr. 2016, 93(1):362 - 377, Refereed - A Divergent Synthesis of Spiropyrazole Derivatives Containing Iminolactone and/or Cyclic Imide Moiety
Eiichi Masumoto; Hiroshi Maruoka; Fumi Okabe; Toshihiro Fujioka; Kenji Yamagata
JOURNAL OF HETEROCYCLIC CHEMISTRY, Jan. 2015, 52(1):48 - 53, Refereed - A DIVERSITY-ORIENTED APPROACH TO 1H-PYRAZOLE-4,5-DIOLS, 4-HYDROXY-3H-PYRAZOL-3-ONES, AND PHENYLHYDRAZONES FROM KEY INTERMEDIATE 4-ACETYLOXY-3H-PYRAZOL-3-ONE
Eiichi Masumoto; Fumi Okabe; Toshihiro Fujioka; Kenji Yamagata; Hiroshi Maruoka
HETEROCYCLES, Nov. 2014, 89(11):2572 - 2587, Refereed - Assessment of the Efficacy of Anticancer Drugs by Amino Acid Metabolomics Using Fluorescence Derivatization-HPLC
Ryoko Tomita; Kenichiro Todoroki; Kazuyuki Machida; Sho Nishida; Hiroshi Maruoka; Hideyuki Yoshida; Toshihiro Fujioka; Manabu Nakashima; Masatoshi Yamaguchi; Hitoshi Nohta
ANALYTICAL SCIENCES, Jul. 2014, 30(7):751 - 758, Refereed - AN EFFICIENT SYNTHETIC ROUTE TOWARDS NOVEL FURO- AND THIENO-TRIAZOLOPYRIDINES
Kazuhiro Tomoike; Hiroshi Maruoka; Fumi Okabe; Eiichi Masumoto; Toshihiro Fujioka; Kenji Yamagata
HETEROCYCLES, Apr. 2014, 89(4):1025 - 1034, Refereed - AN APPROACH TO THE SYNTHESIS OF NOVEL DIHYDROINDOLES BEARING ELECTRON-WITHDRAWING GROUPS AT C-2 POSITION
Fumi Okabe; Hiroshi Maruoka; Masaru Takasu; Eiichi Masumoto; Toshihiro Fujioka; Kenji Yamagata
HETEROCYCLES, Jan. 2014, 88(1):675 - 687, Refereed - SYNTHESIS OF DIHYDROOXEPINS BY THE CYCLOADDITION OF 2-AMINO-4,5-DIHYDRO-3-FURANCARBONITRILES WITH DIMETHYL ACETYLENEDICARBOXYLATE
Fumi Okabe; Hiroshi Maruoka; Eiichi Masumoto; Toshihiro Fujioka; Kenji Yamagata
HETEROCYCLES, Nov. 2013, 87(11):2361 - 2368, Refereed - Synthesis and Biological Activity of Some New Pyrazole Copper(II) Complexes
Hiroshi Maruoka; Sho Nishida; Nobuhiro Kashige; Yuki Yoshimura; Masahiko Omori; Ryoko Tomita; Eiichi Masumoto; Fumi Okabe; Fumio Miake; Kenji Yamagata; Toshihiro Fujioka
JOURNAL OF HETEROCYCLIC CHEMISTRY, Sep. 2012, 49(5):1218 - 1223, Refereed - A Novel Synthesis of 4-Pyridazineacetic Acids via Ring Expansion of N-Cyanomethylated 3-Pyrazoline-4-acetic Acids
MASUMOTO Eiichi; MARUOKA Hiroshi; OKABE Fumi; NISHIDA Sho; TOMITA Ryoko; FUJIOKA Toshihiro; YAMAGATA Kenji
J. Heterocycl. Chem., Jul. 2012, 49(4):893 - 899, Refereed - Dihydrofurans: Synthesis and Reactivity of 2-Amino-4,5-dihydro-3-furancarbonitriles
MARUOKA Hiroshi; OKABE Fumi; YAMAGATA Kenji
Adv. Chem. Res., May 2012, 15:79 - 102, Refereed - Synthesis and biological activities of some new thiazolidine derivatives containing pyrazole ring system
Sho Nishida; Hiroshi Maruoka; Yuki Yoshimura; Takao Goto; Ryoko Tomita; Eiichi Masumoto; Fumi Okabe; Kenji Yamagata; Toshihiro Fujioka
JOURNAL OF HETEROCYCLIC CHEMISTRY, Mar. 2012, 49(2):303 - 309, Refereed - A Divergent Synthesis of Dihydropyridazinones, N-Substituted Dihydropyrazoles, and O-Substituted Pyrazoles
Eiichi Masumoto; Hiroshi Maruoka; Fumi Okabe; Sho Nishida; Yuki Yoshimura; Toshihiro Fujioka; Kenji Yamagata
JOURNAL OF HETEROCYCLIC CHEMISTRY, Jan. 2011, 48(1):96 - 104, Refereed - A CONVENIENT APPROACH TO THE SYNTHESIS OF FURO- AND THIENO-[3,2-c]PYRIDINE DERIVATIVES
Hiroshi Maruoka; Fumi Okabe; Keishi Yamasaki; Eiichi Masumoto; Toshihiro Fujioka; Kenji Yamagata
HETEROCYCLES, Dec. 2010, 82(1):867 - 880, Refereed - SYNTHESIS OF DIHYDROINDOLES AND TETRAHYDROQUINOLINES BY THE INTRAMOLECULAR DIELS-ALDER REACTION OF N-ALKENYLATED 2-ACYLAMINO-3-FURANCARBONITRILES
Hiroshi Maruoka; Fumi Okabe; Yoshimichi Koutake; Eiichi Masumoto; Toshihiro Fujioka; Kenji Yamagata
HETEROCYCLES, Jun. 2010, 81(6):1467 - 1484, Refereed - SYNTHESIS OF FUSED THIOPYRANTHIONE AND THIOPHENE DERIVATIVES FROM 4,5-DIHYDRO-3-THIOPHENE(AND-3-FURAN)-CARBONITRILES HAVING AN ACTIVE METHYLENE GROUP AT C-2 POSITION
Hiroshi Maruoka; Fumi Okabe; Keishi Yamasaki; Eiichi Masumoto; Toshihiro Fujioka; Kenji Yamagata
HETEROCYCLES, Mar. 2010, 81(3):675 - 688, Refereed - A SIMPLE APPROACH TO THE SYNTHESIS OF FUROFURANS AND FUROPYRROLES USING 3-PHENACYLATED TETRAHYDRO-2-IMINO-3-FURANCARBONITRILES
Hiroshi Maruoka; Fumi Okabe; Eiichi Masumoto; Toshihiro Fujioka; Kenji Yamagata
HETEROCYCLES, Jan. 2010, 80(1):637 - 644, Refereed - DIELS-ALDER REACTION OF 2-(CYCLIC AMINO)-SUBSTITUTED 3-FURANCARBONITRILES WITH MALEIMIDES TO PHTHALIMIDES
Hiroshi Maruoka; Fumi Okabe; Yoshimichi Koutake; Toshihiro Fujioka; Kenji Yamagata
HETEROCYCLES, Jan. 2009, 77(1):617 - 628, Refereed - Ring Transformation of Spirocyclopropanepyrazoles into Pyrano[2,3-c]pyrazoles
MARUOKA Hiroshi; MASUMOTO Eiichi; EISHIMA Takafumi; OKABE Fumi; NISHIDA Sho; YOSHIMURA YUKI; FUJIOKA Toshihiro; YAMAGATA KENJI
J. Heterocycl. Chem., 2009, 46(4):782 - 787, Refereed - Synthesis and Antifungal Activity of Spiro [cyclopropane-1,4 '-pyrazol-3-one] Derivatives
Hiroshi Maruoka; Nobuhiro Kashige; Takafumi Eishima; Fumi Okabe; Reiko Tanaka; Toshihiro Fujioka; Fumio Miake; Kenji Yamagata
JOURNAL OF HETEROCYCLIC CHEMISTRY, Nov. 2008, 45(6):1883 - 1887, Refereed - Synthesis and reactions of N-methyl-4-(methylthio)thieno[2,3-d]-pyrimidinium salts
Hiroshi Maruoka; Fumi Okabe; Kenji Yamagata
JOURNAL OF HETEROCYCLIC CHEMISTRY, Sep. 2008, 45(5):1503 - 1508, Refereed - An efficient synthesis of 4-alkoxy-5,6-dihydro-furo (and -thieno)[2,3-d]pyrimidines using zinc chloride/triethylamine reagent system
Hiroshi Maruoka; Fumi Okabe; Kenji Yamagata
JOURNAL OF HETEROCYCLIC CHEMISTRY, Mar. 2008, 45(2):541 - 545, Refereed - Ring-opening reaction of 2-amino-4,5-dihydro-3-furancarbonitriles with carboxylic acids under solvent-free conditions
Hiroshi Maruoka; Fumi Okabe; Kenji Yamagata
SYNTHETIC COMMUNICATIONS, 2008, 38(4):559 - 566, Refereed - A novel synthesis of indole derivatives by the reaction of N-arylhydroxamic acids with malononitrile
Yukihiko Tomioka; Kimiko Ohkubo; Hiroshi Maruoka
JOURNAL OF HETEROCYCLIC CHEMISTRY, Mar. 2007, 44(2):419 - 424, Refereed - 有機合成化学から創薬へのアプローチ
Maruoka Hiroshi
Pharmaceutical bulletin of Fukuoka University, Jan. 2007, 7(1):48 - 52 - Synthesis of substituted 3-pyrrolidinecarbonitriles
Hiroshi Maruoka; Fumi Okabe; Kenji Yamagata
JOURNAL OF HETEROCYCLIC CHEMISTRY, Jan. 2007, 44(1):201 - 203, Refereed - A novel sodium iodide-promoted ring transformation of 2-amino-4,5-dihydro-3-furancarbonitriles to 2-pyrrolidinones and dihydropyrans
Hiroshi Maruoka; Fumi Okabe; Kenji Yamagata
HETEROCYCLES, 2007, 74:383 - 396, Refereed - Synthesis of 1-acyl-1,2-dihydro-3H-pyrazol-3-ones via Lewis acid-mediated rearrangement of 3-acyloxypyrazoles
Hiroshi Maruoka; Kenji Yamagata; Fumi Okabe; Yukihiko Tomioka
JOURNAL OF HETEROCYCLIC CHEMISTRY, Jul. 2006, 43(4):859 - 865, Refereed - Synthesis of new dihydropyrazines with DNA strand-breakage activity
H Maruoka; N Kashige; F Miake; T Yamaguchi
CHEMICAL & PHARMACEUTICAL BULLETIN, Oct. 2005, 53(10):1359 - 1361, Refereed - Synthesis of 2-amino-4,5-dihydro-3-methanesulfonylfurans (and -thiophenes)
K Yamagata; F Okabe; H Maruoka; Y Tagawa
JOURNAL OF HETEROCYCLIC CHEMISTRY, Jul. 2005, 42(5):955 - 958, Refereed - A novel synthesis of 2,3-dihydro-1H-thieno[3,4-b]pyrroles via ring transformation of cyclic sulfonium ylides by titanium(IV) chloride-triethylamine system
H Maruoka; K Yamagata; F Okabe; Y Tomioka
JOURNAL OF HETEROCYCLIC CHEMISTRY, May 2005, 42(4):717 - 721, Refereed - Synthesis of 1-acyl-2-oxo-3-pyrrolidinecarbonitriles by the reaction of 2-acylamino-4,5-dihydro-3-furancarbonitriles with sodium iodide
K Yamagata; F Okabe; H Maruoka; Y Tagawa
JOURNAL OF HETEROCYCLIC CHEMISTRY, May 2005, 42(4):543 - 549, Refereed - Synthesis of Dihydrothieno[2,3-b]pyridines Based on Titanium(IV) Chloride-Mediated Michael Reactions of 2-Amino-4,5-dihydro-3-thiophenecarbonitriles with α,β-Unsaturated Ketones
H Maruoka; M Yamazaki; Y Tomioka
JOURNAL OF HETEROCYCLIC CHEMISTRY, Jul. 2004, 41(4):641 - 646, Refereed - Reactions of nitroarenes with secondary and tertiary carbanions bearing both a leaving group and electron-withdrawing group: An approach to dihydronaphth [2,1-c]isoxazole N-oxides and dihydroisoxazolo[4,3-f]quinoline N-oxides
H Maruoka; Y Tomioka
JOURNAL OF HETEROCYCLIC CHEMISTRY, Nov. 2003, 40(6):1051 - 1057, Refereed - Synthesis and 1,3-dipolar cycloaddition reactions of N-aryl-C,C-dimethoxycarbonylnitrones
Y Tomioka; C Nagahiro; Y Nomura; H Maruoka
JOURNAL OF HETEROCYCLIC CHEMISTRY, Jan. 2003, 40(1):121 - 127, Refereed - Synthesis of Dihydrofuro[2,3-b]pyridines by the Reaction of 2-Amino-4,5-dihydro-3-furancarbonitriles with α,β-Unsaturated Carbonyl Compounds
H Maruoka; M Yamazaki; Y Tomioka
JOURNAL OF HETEROCYCLIC CHEMISTRY, Jul. 2002, 39(4):743 - 749, Refereed - Synthesis of 3,4-dihydro-2H-thiopyrans by the reaction of 4,5-dihydrothiophenium-1-bis[ethoxy(and methoxy)carbonyl]methylides with sodium iodide
H Maruoka; K Yamagata; M Yamazaki
JOURNAL OF HETEROCYCLIC CHEMISTRY, Jan. 2002, 39(1):217 - 220, Refereed - Synthesis of 5,6-dihydrothieno(and furo)pyrimidines bearing an active methine group at the 4-position
H Maruoka; K Yamagata; M Yamazaki
JOURNAL OF HETEROCYCLIC CHEMISTRY, Jan. 2001, 38(1):269 - 274, Refereed - Studies on the Reactions of 2-Amino-4,5-dihydro-3-furan(and -3-thiophene)carbonitriles mainly with Nucleophilic Reagents.
Hiroshi Maruoka
福岡大学薬学紀要, 1998, 22:1 - 12 - SYNTHESIS OF 3-ACYL-5,6-DIHYDRO-2-PHENYLTHIENO(-FURO-)[2,3-D]PYRIMIDIN-4(3H)-ONES
H MARUOKA; K YAMAGATA; M YAMAZAKI
LIEBIGS ANNALEN DER CHEMIE, Oct. 1994, (10):993 - 997, Refereed - A Convenient One-Pot Synthesis of Ethyl 4-Amino-2,3-dihydrothieno[2,3-b]pyridine-5-carboxylates
Hiroshi Maruoka; Kenji Yamagata; Motoyoshi Yamazaki
Liebigs Ann.Chem., 1993, :1269 - 1271, Refereed - Reactions of Ethyl N-2-(3-Cyano-4,5-dihydro-2-furyl)carbamates with Sodium Iodide
Hiroshi Maruoka; Kenji Yamagata; Motoyoshi Yamazaki
Liebigs Ann.Chem., 1993, :625 - 627, Refereed - RING-OPENING OF 2-ACYLAMINO-4,5-DIHYDRO-3-FURANCARBONITRILES BY USE OF TITANIUM(IV) CHLORIDE
H MARUOKA; K YAMAGATA; M YAMAZAKI
HETEROCYCLES, Nov. 1990, 31(11):2011 - 2023, Refereed - RING CONVERSION OF 2-AMINO-4,5-DIHYDRO-3-FURANCARBONITRILES CATALYZED BY HALIDE-IONS
K YAMAGATA; H MARUOKA; Y HASHIMOTO; M YAMAZAKI
HETEROCYCLES, Jan. 1989, 29(1):5 - 9, Refereed - CONVERSION OF (-)-LIMONEN-10-OL TO 11-DEOXYPROSTAGLANDIN
H SUEMUNE; H MARUOKA; S SAEKI; K SAKAI
CHEMICAL & PHARMACEUTICAL BULLETIN, Nov. 1986, 34(11):4629 - 4634, Refereed
■ Lectures, oral presentations, etc.
- ピラゾール-プロパルギルアルコール誘導体の反応一般性について：新規4-ヒドロキシピラゾール誘導体の合成研究
Takafumi Fujita; Fumi Okabe-Nakahara; Hiroshi Maruoka; Eiichi Masumoto
第50回反応と合成の進歩シンポジウム, 27 Oct. 2024 - 三環系縮合pyrido[2,3-d]pyrimidine誘導体の合成研究
岡部-中原 史; 小林 真里; 藤田 崇史; 益本 英一; 丸岡 博
日本薬学会第144年会, 31 Mar. 2024 - 三環系縮合pyazolo[3,4-b]pyridine誘導体の合成研究
岡部-中原 史; 清水 菜々子; 井手 彩夏; 加峯 綾乃; 藤田 崇史; 益本 英一; 丸岡 博
日本薬学会第144年会, 31 Mar. 2024 - 三環系縮合pyazolo[3,4-b]pyridine誘導体の合成研究
岡部-中原 史; 今田 みのり; 藤田 崇史; 益本 英一; 丸岡 博
日本薬学会第144年会, 31 Mar. 2024 - 三環系縮合pyrrolo[2,3-b]pyridine誘導体の合成研究
岡部-中原 史; 自見 紗矢子; 藤田 崇史; 益本 英一; 丸岡 博
日本薬学会第144年会, 31 Mar. 2024 - 新規スピロ[ベンゾオキサジン-2,4'-ピラゾール]誘導体の合成研究
益本 英一; 堀岡 麻衣; 藤田 崇史; 岡部-中原 史; 丸岡 博
日本薬学会第144年会, 31 Mar. 2024 - ピラゾール-プロパルギルアルコール類の環変換反応を利用した新規 4-ヒドロキシピラゾール誘導体の合成研究 (3)
藤田 崇史; 益本 英一; 岡部-中原 史; 丸岡 博
日本薬学会第144年会, 31 Mar. 2024 - 三環系縮合imidazo[1,2-a]pyridine誘導体の合成研究
OKABE-NAKAHARA Fumi; MIHARA Yuuna; MASUMOTO Eiichi; MARUOKA Hiroshi
日本薬学会第143年会, 26 Mar. 2023 - 新規スピロ-1,3,4-オキサジアゾール-ピラゾロン誘導体の合成研究
MASUMOTO Eiichi; IHARA Kazutoshi; SEKI Hanae; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
日本薬学会第143年会, 26 Mar. 2023 - 4-ヒドロキシピラゾール類を鍵化合物とする新規ヘテロ環連結ピラゾール誘導体の合成研究
MASUMOTO Eiichi; SHINDO Saori; KOBAYASHI Kouhei; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
日本薬学会第143年会, 26 Mar. 2023 - Furo-pyrrolo-azepine 類の合成研究
Okabe-NAKAHARA Fumi; YOSHIDA Kaname; OOTSUKA Sari; SAISYOUJI Masahiro; NAGABUCHI Hayate; Masumoto Eiichi; MARUOKA Hiroshi
日本薬学会第142年会, 27 Mar. 2022, 日本薬学会 - ピラゾール-プロパルギルアルコール類の環変換反応を利用した新規4-ヒドロキシピラゾール誘導体の合成研究（２）
MASUMOTO Eiichi; HARADA Yurie; MINAMI Ruriko; NAGABUCHI Hayate; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
日本薬学会第142年会, 27 Mar. 2022 - スピロ-エポキシ-ピラゾール-3-オン誘導体の合成と反応に関する研究
NAGABUCHI Hayate; Masumoto Eiichi; HIKITA Mayu; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
日本薬学会第141年会, 27 Mar. 2021 - 新規スピロ[ピラゾール-4,2′-キナゾリン]-5,4′-ジオン誘導体の合成研究
MASUMOTO Eiichi; NAGABUCHI Hayate; MIKURIYA Azusa; CHIJIIWA Risa; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
日本薬学会第141年会, 27 Mar. 2021, 日本薬学会 - ピラゾール-4,5-ジオン類とメチルケトン類のアルドール反応について：新規スピロ[イソオキサゾリン-5,4'-ピラゾール]誘導体の合成研究（３）
SHIROUZU Emi; MASUMOTO Eiichi; NAGABUCHI Hayate; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
日本薬学会第140年会, 28 Mar. 2020 - ピラゾール－プロパルギルアルコール類の環変換反応を利用した新規4－ヒドロキシピラゾール誘導体の合成研究
MASUMOTO Eiichi; UMENO Koki; KAZUYOSHI Yoshiro; NAGABUCHI Hayate; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
日本薬学会第140年会, 26 Mar. 2020, 日本薬学会 - ピラゾール-4-エナミンを鍵化合物としたピラゾール-チアゾリジン誘導体の合成
NAGABUCHI Hayate; KASHIGE Nobuhiro; MASUMOTO Eiichi; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
日本薬学会第140年会, 26 Mar. 2020 - Synthetic Studies of Novel Spiro Pyrazol-3-ones Containing Quinazoline and/or Oxirane Moiety
NAGABUCHI Hayate; MASUMOTO Eiichi; OKABE-NAKAHARA Fumi; MARUOKA Hiroshi
The 21st European Symposium on Organic Chemistry, 16 Jul. 2019 - 新規ピラゾール-チアゾール誘導体の合成と生物活性評価について
MASUMOTO Eiichi; KASHIGE Nobuhiro; OKABE-NAKAHARA Fumi; MIAKE Fumio; YAMAGATA Kenji; MARUOKA Hiroshi
日本薬学会第139年会, 21 Mar. 2019, 日本薬学会 - 多置換スピロ[ピラゾール-4,2'-キナゾリン]誘導体の合成（２）
NAGABUCHI Hayate; MASUMOTO Eiichi; OKBE-NAKAHARA Fumi; YAMAGATA Kenji; MARUOKA Hiroshi
日本薬学会第139年会, 21 Mar. 2019, 日本薬学会 - 三環系縮合 furo[2,3-b]pyridine 誘導体の合成
NAKAHARA Fumi; Inoue Tatsunari; Matsuoka Yumi; Masumoto Eiichi; MARUOKA Hiroshi; YAMAGATA KENJI
日本薬学会第139年会, 21 Mar. 2019 - 新規スピロ[イソオキサゾリン-5,4'-ピラゾール]誘導体の合成と生物活性評価について
SHIROUZU Emi; MASUMOTO Eiichi; KASHIGE Nobuhiro; OKABE-NAKAHARA Fumi; MIAKE Fumio; YAMAGATA Kenji; MARUOKA Hiroshi
第３５回日本薬学会九州支部大会, 17 Nov. 2018, 日本薬学会日本薬学会九州支部 - ピラゾール-4,5-ジオン類、2-アミノベンゾフェノン類および酢酸アンモニウムを用 いた三成分連結反応による新規スピロ[ピラゾール-4,2'-キナゾリン]誘導体の合成 研究
Masumoto Eiichi; OKABE-NAKAHARA Fumi; YAMAGATA KENJI; MARUOKA Hiroshi
日本薬学会第138年会, 27 Mar. 2018, 日本薬学会 - 新規スピロ[シクロブタチアゾール-4,4’-ピラゾール]誘導体の合成研究
Masumoto Eiichi; OKABE-NAKAHARA Fumi; YAMAGATA KENJI; MARUOKA Hiroshi
日本薬学会第138年会, 27 Mar. 2018, 日本薬学会 - Methyl Cyano-(3-cyanofuranylidene)acetate 、hydrazine類およびdimethylformamide dimethyl acetal との反応による新規 angular および linear [5-6-5] 縮合ヘテロ環化合物の合成
NAKAHARA Fumi; Masumoto Eiichi; MARUOKA Hiroshi; YAMAGATA KENJI
日本薬学会第138年会, 27 Mar. 2018, 日本薬学会 - 2-Amino-4,5-dihydro-3-furancarbonitrileとPhenylenediamine類のドミノ反応を利用した新規Benzimidazole誘導体の合成
NAKAHARA Fumi; Nagabuchi Hayate; Shiba Yasuko; Masumoto Eiichi; MARUOKA Hiroshi; YAMAGATA KENJI
日本薬学会第138年会, 27 Mar. 2018, 日本薬学会 - 三成分連結反応による新規スピロ[ジヒドロピリジン-4,4'-ピラゾール-3'-オン]誘導体の合成研究」
SHIROUZU Emi; MASUMOTO Eiichi; NAKAHARA Fumi; YAMAGATA KENJI; MARUOKA Hiroshi
47th Congress of Heterocyclic Chemistry, 26 Oct. 2017 - 超原子価ヨウ素試薬を用いた新規スピロピラゾール-3-オン誘導体の合成
Masumoto Eiichi; Shirouzu Emi; NAKAHARA Fumi; YAMAGATA KENJI; MARUOKA Hiroshi
日本薬学会第137年会, 25 Mar. 2017 - Novel Pyrazole Metal Complexes: Synthesis and Reactions of Trisspiro(3H-pyrazole-3-one) Derivative
MARUOKA Hiroshi; KASHIGE Nobuhiro; TOMITA Ryoko; Masumoto Eiichi; MIAKE Fumio; YAMAGATA Kenji; FUJIOKA Toshihiro
The 19th European Symposium on Organic Chemistry, 13 Jul. 2015 - Synthesis and Reactions of 4-Acyloxy-3H-pyrazol-3-ones: Biological Activities of Novel Synthesized Compounds
Masumoto Eiichi; MARUOKA Hiroshi; KASHIGE Nobuhiro; OKABE Fumi; MIAKE Fumio; FUJIOKA Toshihiro; YAMAGATA KENJI
The 19th European Symposium on Organic Chemistry, 13 Jul. 2015 - トリススピロ（3H-ピラゾール-3-オン）誘導体の合成と反応
MARUOKA Hiroshi; ESAKI Ayaka; NISHIDA Sho; TOMITA Ryoko; FUJIOKA Toshihiro
The 135th Pharmaceutical Society of Japan, 27 Mar. 2015, The Pharmaceutical Society of Japan - LC-MS/MSによるアミノ酸メタボロミクス ー低酸素・栄養飢餓状態で培養した大腸がん細胞DLD1についてー
TOMITA Ryoko; NISHIDA Sho; HAYAMA Tadashi; TODOROKI Kenichiro; YOSHIDA Hideyuki; MARUOKA Hiroshi; NAKASHIMA Manabu; NOHTA Hitoshi; YAMAGUCHI Masatoshi; FUJIOKA Toshihiro
日本薬学会第135年会, 27 Mar. 2015 - Angular型およびLinear型[5-6-5]三環系縮合ヘテロ環化合物の合成
TOMOIKE Kazuhiro; OKABE Fumi; MARUOKA Hiroshi; Masumoto Eiichi; FUJIOKA Toshihiro; YAMAGATA KENJI
日本薬学会第135年会, 27 Mar. 2015 - オキシムを有する新規ピラゾール誘導体の合成研究
Masumoto Eiichi; MARUOKA Hiroshi; OKABE Fumi; FUJIOKA Toshihiro; YAMAGATA KENJI
第40回反応と合成の進歩シンポジウム, 10 Nov. 2014 - Angular型三環系[5-6-5]縮合ヘテロ環化合物の合成
TOMOIKE Kazuhiro; OKABE Fumi; MARUOKA Hiroshi; Masumoto Eiichi; FUJIOKA Toshihiro; YAMAGATA KENJI
44th Congress of Heterocyclic Chemistry, 10 Sep. 2014 - 腫瘍細胞増殖抑制成分の探索〜ユーカリ（Eucalyptus globulus）の葉に含まれる活性成分について〜
西田翔; 田中麻衣子; 久米沙智美; 敷島友喜; 石田拓也; 富田陵子; 丸岡博; 益本英一; 岡部史; 山方健司; 神村英利; 藤岡稔大
日本薬学会第134年会, 29 Mar. 2014 - Synthesis and Evaluation for Biological Activities of Some New Pyrazole-Thiazolidine Derivatives
MARUOKA Hiroshi; KASHIGE Nobuhiro; NISHIDA Sho; TOMITA Ryoko; TANAKA Reiko; MIAKE Fumio; YAMAGATA Kenji; FUJIOKA Toshihiro
The 18th European Symposium on Organic Chemistry, 11 Jul. 2013 - A Divergent Synthesis of 4-Pyridazineacetic Acids and Spiropyrazoles Starting from 1H-Pyrazol-4-acetic Acids
MASUMOTO Eiichi; MARUOKA Hiroshi; OKABE Fumi; FUJIOKA Toshihiro; YAMAGATA Kenji
The 18th European Symposium on Organic Chemistry, 11 Jul. 2013 - 新規1,2,4-triazolo[1,5-a]pyridine類の合成
TOMOIKE Kazuhiro; OKABE Fumi; MARUOKA Hiroshi; Masumoto Eiichi; FUJIOKA Toshihiro; YAMAGATA KENJI
日本薬学会第133年会, 30 Mar. 2013 - 2-アミノフラン類の分子内Diels-Alder反応を利用したindoline誘導体合成
TAKASU Masaru; OKABE Fumi; MARUOKA Hiroshi; Masumoto Eiichi; FUJIOKA Toshihiro; YAMAGATA KENJI
日本薬学会第133年会, 30 Mar. 2013 - 4-アセチルオキシピラゾール-3-オンを鍵化合物とする新規ピラゾール-4,5-ジオール、4-ヒドロキシピラゾール-3-オンおよびフェニルヒドラゾン誘導体の合成
Masumoto Eiichi; MARUOKA Hiroshi; OKABE Fumi; FUJIOKA Toshihiro; YAMAGATA KENJI
日本薬学会第133年会, 28 Mar. 2013 - アミノ酸メタボロミクスを用いた抗がん剤の治療効果判定法の開発 (3)
TOMITA Ryoko; NISHIDA Sho; MARUOKA Hiroshi; Todoroki Kenichiro; NAKASHIMA Manabu; NOHTA Hitoshi; YAMAGUCHI Masatoshi; YAMAGATA Kenji; FUJIOKA Toshihiro
The 133rd Annual Meeting of the Pharmaceutical Society of Japan, 28 Mar. 2013 - カキ (Diospyros kaki) の生活習慣病改善作用に関する検討
TOMITA Ryoko; ODA Naoko; NISHIDA Sho; MARUOKA Hiroshi; Masumoto Eiichi; OKABE Fumi; YAMAGATA KENJI; FUJIOKA Toshihiro
日本薬学会第132年会, 30 Mar. 2012 - 2-アミノフラン誘導体とマレイミド類とのDiels-Alder反応を利用した新規N-アリールフタルイミド誘導体の合成
TAKASU Masaru; OKABE Fumi; MARUOKA Hiroshi; Masumoto Eiichi; FUJIOKA Toshihiro; YAMAGATA KENJI
日本薬学会第132回年会, 30 Mar. 2012 - タカナ (Brassica juncea var. integrifolia) の生活習慣病改善作用に関する基礎的検討
NISHIDA Sho; HIGASHI Yurina; HAMASAKI Maya; TOMITA Ryoko; MARUOKA Hiroshi; Masumoto Eiichi; OKABE Fumi; YAMAGATA KENJI; KAWASAKI Youichi; OGIHARA Hiroyuki; OGIHARA Kazutoshi; FUJIOKA Toshihiro
The 132nd Annual Meeting of the Pharmaceutical Society of Japan, 30 Mar. 2012 - Synthesis and Evaluation for Biological Activities of Some New Thiazolidine Derivatives Containing Pyrazole Ring System
MARUOKA Hiroshi; NISHIDA Sho; KASHIGE Nobuhiro; YOSHIMURA Yuki; GOTO Takao; TOMITA Ryoko; Masumoto Eiichi; OKABE Fumi; TANAKA Reiko; MIAKE Fumio; YAMAGATA KENJI; FUJIOKA Toshihiro
17th European Synposium on Organic Chemistry, 12 Jul. 2011 - 新規トリス(3H-ピラゾール-3-オン) 誘導体の抗糖尿病活性について
NISHIDA Sho; SEKI Mika; TOMITA Ryoko; MARUOKA Hiroshi; Masumoto Eiichi; OKABE Fumi; YAMAGATA Kenji; FUJIOKA Toshihiro
日本薬学会第131年会, 31 Mar. 2011 - ピラゾール誘導体のシアノメチル化反応とスピロ-ピラゾール誘導体合成への応用
Masumoto Eiichi; Maruoka Hiroshi; Okabe Fumi; Nishida Sho; Tomita Ryoko; Fujioka Toshihiro; Yamagta Kenji
第27回日本薬学会九州支部大会, 11 Dec. 2010 - 新規ピラゾール-チアゾリジン誘導体の抗悪性腫瘍および抗糖尿病効果の検討
GOTOU Takao; HIRANO Tatsuya; OUMORI Masahiko; YOSHIMURA Yuki; MARUOKA Hiroshi; NISHIDA Sho; MASUMOTO Eiichi; OKABE Fumi; YAMAGATA Kenji; FUJIOKA Toshihiro
日本薬学会第130年会, 30 Mar. 2010 - 抗糖尿病効果成分の探索-オクラ、ゴーヤ、ユーカリおよびドクダミについて〜
HIRANO Tatsuya; YOSHIMURA Yuki; NISHIDA Sho; MARUOKA Hiroshi; MASUMOTO Eiichi; OKABE Fumi; YAMAGATA Kenji; FUJIOKA Toshihiro
日本薬学会第130年会, 30 Mar. 2010 - 新規イソインドール、イソベンゾフラン、インドールおよびキノリン類の合成研究
KOUTAKE Yoshimichi; OKABE Fumi; MARUOKA Hiroshi; MASUMOTO Eiichi; FUJIOKA Toshihiro; YAMAGATA Kenji
日本薬学会第130年会, 28 Mar. 2010 - 新規縮合チオフェン、チオピランおよびピリジン誘導体の合成研究
YAMASAKI Keishi; OKABE Fumi; MARUOKA Hiroshi; MASUMOTO Eiichi; FUJIOKA Toshihiro; YAMAGATA Kenji
日本薬学会第130年会, 28 Mar. 2010 - ピラゾール誘導体のシアノメチル化反応とピリダジノン誘導体合成への応用
MASUMOTO Eiichi; MARUOKA Hiroshi; OKABE Fumi; YOSHIMURA Yuki; NISHIDA Sho; FUJIOKA Toshihiro; YAMAGATA Kenji
第26回日本薬学会九州支部大会, 13 Dec. 2009 - 新規ピラゾール誘導体とそのナトリウム塩および銅錯体の腫瘍細胞に及ぼす影響（その２）
OMORIMasahiko; YOSHIMURA Yuki; NISHIDA Sho; MARUOKA Hiroshi; KASHIGE Nobuhiro; MASUMOTO Eiichi; OKABE Fumi; MIAKE Fumio; YAMAGATA Kenji; FUJIOKA Toshihiro
第26回日本薬学会九州支部大会, 12 Dec. 2009 - ピラゾール-チアゾリジン誘導体の合成および腫瘍細胞に対する増殖抑制効果の検討（その２）
GOTO Takao; HIRANO Tatsuya; OMORI Masahiko; YOSHIMURA Yuki; NISHIDA Sho; MARUOKA Hiroshi; MASUMOTO Eiichi; OKABE Fumi; YAMAGATA Kenji; FUJIOKA Toshihiro
第26回日本薬学会九州支部大会, 12 Dec. 2009 - 青汁原料ケールの抗糖尿病効果
NISHIDA Sho; YOSHIMURA Yuki; MARUOKA Hiroshi; SUZUKI Asahi; FUJIOKA Toshihiro
第11回応用薬理シンポジウム, 19 Sep. 2009 - Features and Applications of Reactions of 4-Ylidene-3H-pyrazol-3-ones: Synthesis and Antifungal Activity of New Pyrazole Derivatives
MARUOKA Hiroshi; MASUMOTO Eiichi; HOKAO Masataka; KASHIGE Nobuhiro; OKABE Fumi; NISHIDA Sho; YOSHIMURA Yuki; YOSHIMURA Yuki; MIAKE Fumio; FUJIOKA Toshihiro; YAMAGATA KENJi
The 16th European Symposium on Organic Chemistry, 14 Jul. 2009 - 新規ジヒドロチオフェンおよびジヒドロフラン縮合ヘテロ環化合物の合成
YAMASAKI Keishi; OKABE Fumi; MARUOKA Hiroshi; FUJIOKA Toshihiro; YAMAGATA Kenji
日本薬学会第129年会, 28 Mar. 2009 - Diels-Alder反応を利用した2-ジ置換アミノ-3-フランカルボニトリル類からジヒドロイソインドールおよびジヒドロインドール類の合成
KOUTAKE Yoshimichi; OKABE Fumi; MARUOKA Hiroshi; FUJIOKA Toshihiro; YAMAGATA Kenji
日本薬学会第129年会, 28 Mar. 2009 - 4-アルキリデン-3H-ピラゾール-3-オン類から合成された新規ピラゾール誘導体の抗真菌活性について
HOKAO Masataka; MARUOKA Hiroshi; KASHIGE Nobuhiro; OKABE Fumi; NISHIDA Sho; YOSHIMURA Yuki; TANAKA Reiko; MIAKE Fumio; FUJIOKA Toshihiro; YAMAGATA Kenji
日本薬学会第129年会, 27 Mar. 2009 - スピロシクロプロパンピラゾロン類から合成された新規ピラゾール誘導体の抗真菌活性について
EIICHI Masumoto; MARUOKA Hiroshi; KASHIGE Nobuhiro; OKABE Fumi; NISHIDA Sho; YOSHIMURA Yuki; TANAKA Reiko; MIAKE Fumio; FUJIOKA Toshihiro; YAMAGATA Kenji
日本薬学会第129年会, 27 Mar. 2009 - ピラゾロン-チアゾリジン誘導体の合成および腫瘍細胞に対する増殖抑制効果の検討
GOTO Takao; HIRANO Tatsuya; OMORI Masahiko; YOSHIMURA Yuki; NISHIDA Sho; MARUOKA Hiroshi; OKABE Fumi; YAMAGATA Kenji; FUJIOKA Toshihiro
日本薬学会第129年会, 26 Mar. 2009 - 新規ピラゾール誘導体とそのナトリウム塩および銅錯体の腫瘍細胞に及ぼす影響
OMORI Masahiko; YOSHIMURA Yuki; NISHIDA Sho; MARUOKA Hiroshi; OKABE Fumi; YAMAGATA Kenji; FUJIOKA Toshihiro
日本薬学会第129年会, 26 Mar. 2009 - フェンタニルを用いた鎮痛効果の日周リズムを考慮した投薬設計法の開発（その２）
NAKAO Keisuke; YOSHIMURA Yuki; NISHIDA Sho; YOSHIDA Miyako; MARUOKA Hiroshi; OKABE Fumi; YAMAGATA Kenji; FUJIOKA Toshihiro
日本薬学会第129年会, 26 Mar. 2009 - 「こんにゃくパウダー」の生活習慣病に及ぼす影響
SOGA Shigetada; YOSHIMURA Yuki; NISHIDA Sho; MARUOKA Hiroshi; OKABE Fumi; YAMAGATA Kenji; ISHIBASHI Wataru; FUJIOKA Toshihiro
日本薬学会第129年会, 26 Mar. 2009 - フェンタニルを用いた鎮痛効果の日周リズムを考慮した投薬設計法の開発
NAKAO Keisuke; YOSHIMURA Yuki; NISHIDA Sho; YOSHIDA Miyako; MARUOKA Hiroshi; OKABE Fumi; YAMAGATA Kenji; MISHIMA Ken-Ichi; FUJIWARA Michihiro; FUJIOKA Toshihiro
第２５回日本薬学会九州支部大会, 07 Dec. 2008 - 新規ジヒドロピリダジノンおよびピラゾール誘導体の合成
MASUMOTO Eiichi; MARUOKA Hiroshi; OKABE Fumi; YOSHIMURA YUKI; FUJIOKA Toshihiro; YAMAGATA KENJI
第３８回複素環化学討論会, 22 Nov. 2008 - 4-アルキリデン-3H-ピラゾール-3-オン類の性質と反応：新規ピラゾール誘導体の合成
HOKAO Masataka; MARUOKA Hiroshi; OKABE Fumi; YOSHIMURA YUKI; FUJIOKA Toshihiro; YAMAGATA KENJI
第３８回複素環化学討論会, 22 Nov. 2008
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