Association of T cell infiltration and morphological change of thymus gland with the aggravation of pulmonary emphysema in testosterone deficiency.
Kentaro Aono; Junichi Matsumoto; Taichi Matsumoto; Mitsuhisa Koga; Keisuke Migita; Koji Tominaga; Shinsuke Nakagawa; Atsushi Yamauchi
Biochemistry and biophysics reports, Jul. 2023, 34:101489 - 101489

Effects of fasudil on blood-brain barrier integrity.
Kei Sato; Shinsuke Nakagawa; Yoichi Morofuji; Yuki Matsunaga; Takashi Fujimoto; Daisuke Watanabe; Tsuyoshi Izumo; Masami Niwa; Fruzsina R Walter; Judit P Vigh; Ana Raquel Santa-Maria; Maria A Deli; Takayuki Matsuo
Fluids and barriers of the CNS, 03 Jun. 2022, 19(1):43 - 43

Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer.
Yoichi Morofuji; Shinsuke Nakagawa; Kenta Ujifuku; Takashi Fujimoto; Kaishi Otsuka; Masami Niwa; Keisuke Tsutsumi
Pharmaceuticals (Basel, Switzerland), 26 Jan. 2022, 15(2)

脳毛細血管内皮細胞におけるMAP kinase経路とペリサイト、アストロサイトのクロストークが造影剤誘発性血液脳関門障害に関与する
松永 裕希; 中川 慎介; 諸藤 陽一; 堀江 信貴; 出雲 剛; 陶山 一彦; 松尾 孝之
脳血管内治療, Nov. 2021, 6(Suppl.):S126 - S126

急性期脳梗塞治療としてのファスジル動注療法の可能性
佐藤 慧; 諸藤 陽一; 中川 慎介; 藤本 隆史; 松永 裕希; 堀江 信貴; 出雲 剛; 松尾 孝之
脳血管内治療, Nov. 2021, 6(Suppl.):S134 - S134

Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes.
Daisuke Watanabe; Shinsuke Nakagawa; Yoichi Morofuji; Andrea E Tóth; Monika Vastag; Jun Aruga; Masami Niwa; Mária A Deli
Pharmaceutics, 16 Sep. 2021, 13(9)

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction
Takata F; Nakagawa S; Matsumoto J; Dohgu S
Front Cell Neurosci., 13 Sep. 2021, 15:661838, Refereed

MAP Kinase Pathways in Brain Endothelial Cells and Crosstalk with Pericytes and Astrocytes Mediate Contrast-Induced Blood-Brain Barrier Disruption.
Yuki Matsunaga; Shinsuke Nakagawa; Yoichi Morofuji; Shinya Dohgu; Daisuke Watanabe; Nobutaka Horie; Tsuyoshi Izumo; Masami Niwa; Fruzsina R Walter; Ana Raquel Santa-Maria; Maria A Deli; Takayuki Matsuo
Pharmaceutics, 17 Aug. 2021, 13(8)

FTY720 Exacerbates Blood-Brain Barrier Dysfunction Induced by IgG Derived from Patients with NMO and MOG Disease.
Shunsuke Yoshimura; Shinsuke Nakagawa; Toshiyuki Takahashi; Keiko Tanaka; Akira Tsujino
Neurotoxicity research, Aug. 2021, 39(4):1300 - 1309

Testosterone deficiency promotes the development of pulmonary emphysema in orchiectomized mice exposed to elastase.
Kentaro Aono; Junichi Matsumoto; Shinsuke Nakagawa; Taichi Matsumoto; Mitsuhisa Koga; Keisuke Migita; Koji Tominaga; Yuna Sakai; Atsushi Yamauchi
Biochemical and biophysical research communications, 18 Jun. 2021, 558:94 - 101

Biology of Pericytes – Recent Advances: Role of Pericytes in Brain Metastasis
Yoichi Morofuji; Shinsuke Nakagawa; Takashi Fujimoto; Susumu Yamaguchi; Kenta Ujifuku; Takayuki Matsuo
Stem Cell Biology and Regenerative Medicine, 2021, :75 - 98

Exploration of Pericyte-Derived Factors Implicated in Lung Cancer Brain Metastasis Protection: A Pilot Messenger RNA Sequencing Using the Blood-Brain Barrier In Vitro Model
Kenta Ujifuku; Takashi Fujimoto; Kei Sato; Yoichi Morofuji; Hideki Muto; Hiroshi Masumoto; Shinsuke Nakagawa; Masami Niwa; Takayuki Matsuo
CELLULAR AND MOLECULAR NEUROBIOLOGY, Nov. 2020, Refereed

Defective Function of the Blood–Brain Barrier in a Stroke-Prone Spontaneously Hypertensive Rat: Evaluation in an In Vitro Cell Culture Model
Shinsuke Nakagawa; Hiroki Ohara; Masami Niwa; Kazuo Yamagata; Toru Nabika
Cellular and Molecular Neurobiology, 09 Jul. 2020, Refereed
Lead

Comparison of the rate of dedifferentiation with increasing passages among cell sources for an in vitro model of the blood-brain barrier.
Takashi Fujimoto; Yoichi Morofuji; Shinsuke Nakagawa; Andrej Kovac; Nobutaka Horie; Tsuyoshi Izumo; Masami Niwa; Takayuki Matsuo; William A Banks
Journal of neural transmission (Vienna, Austria : 1996), 07 May 2020, 127(8):1117 - 1124, Refereed

Drug Development for Central Nervous System Diseases Using In vitro Blood-brain Barrier Models and Drug Repositioning.
Yoichi Morofuji; Shinsuke Nakagawa
Current pharmaceutical design, 2020, 26(13):1466 - 1485, Refereed
Last

Pericytes Suppress Brain Metastasis from Lung Cancer In Vitro.
Takashi Fujimoto; Shinsuke Nakagawa; Yoichi Morofuji; Daisuke Watanabe; Kenta Ujifuku; Nobutaka Horie; Tsuyoshi Izumo; Masami Niwa; William A Banks; Maria A Deli; Takayuki Matsuo
Cellular and molecular neurobiology, Jan. 2020, 40(1):113 - 121, Refereed

Sphingosine 1-Phosphate Signaling Is Involved in Impaired Blood–Brain Barrier Function in Ischemia–Reperfusion Injury
NAKAGAWA Shinsuke
Molecular Neurobiology, Dec. 2019, 57(3):1594 - 1606, Refereed

In vitro analysis of drugs that improve hyperglycemia-induced blood-brain barrier dysfunction.
Ryoma Kayano; Yoichi Morofuji; Shinsuke Nakagawa; Shuji Fukuda; Daisuke Watanabe; Hiroki Ozawa; Masami Niwa; Takayuki Matsuo
Biochemical and biophysical research communications, 10 Sep. 2018, 503(3):1885 - 1890, Refereed

Lysophosphatidic acid receptor, LPA6, regulates endothelial blood-brain barrier function: Implication for hepatic encephalopathy
Kayo Masago; Yasuyuki Kihara; Keisuke Yanagida; Fumie Hamano; Shinsuke Nakagawa; Masami Niwa; Takao Shimizu
Biochemical and Biophysical Research Communications, 02 Jul. 2018, 501(4):1048 - 1054, Refereed

Glucagon-Like Peptide-1 Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells Under Basal and Hyperglycemia Conditions
Shuji Fukuda; Shinsuke Nakagawa; Rie Tatsumi; Yoichi Morofuji; Tomonori Takeshita; Kentaro Hayashi; Kunihiko Tanaka; Takayuki Matsuo; Masami Niwa
JOURNAL OF MOLECULAR NEUROSCIENCE, Jun. 2016, 59(2):211 - 219, Refereed

Candesartan Improves Ischemia-Induced Impairment of the Blood-Brain Barrier In Vitro
Gohei So; Shinsuke Nakagawa; Yoichi Morofuji; Takeshi Hiu; Kentaro Hayashi; Kunihiko Tanaka; Kazuhiko Suyama; Maria A. Deli; Izumi Nagata; Takayuki Matsuo; Masami Niwa
CELLULAR AND MOLECULAR NEUROBIOLOGY, May 2015, 35(4):563 - 572, Refereed

Cilostazol attenuates ischemia-reperfusion-induced blood-brain barrier dysfunction enhanced by advanced glycation endproducts via transforming growth factor-β1 signaling.
Tomonori Takeshita; Shinsuke Nakagawa; Rie Tatsumi; Gohei So; Kentaro Hayashi; Kunihiko Tanaka; Maria A. Deli; Izumi Nagata; Masami Niwa
MOLECULAR AND CELLULAR NEUROSCIENCE, May 2014, 60:1 - 9, Refereed

Hepatocyte growth factor enhances the barrier function in primary cultures of rat brain microvascular endothelial cells
Narumi Yamada; Shinsuke Nakagawa; Shoji Horai; Kunihiko Tanaka; Maria A. Deli; Hiroshi Yatsuhashi; Masami Niwa
MICROVASCULAR RESEARCH, Mar. 2014, 92:41 - 49, Refereed

Initial Contact of Glioblastoma Cells with Existing Normal Brain Endothelial Cells Strengthen the Barrier Function via Fibroblast Growth Factor 2 Secretion: A New In Vitro Blood-Brain Barrier Model
Keisuke Toyoda; Kunihiko Tanaka; Shinsuke Nakagawa; Dinh Ha Duy Thuy; Kenta Ujifuku; Kensaku Kamada; Kentaro Hayashi; Takayuki Matsuo; Izumi Nagata; Masami Niwa
CELLULAR AND MOLECULAR NEUROBIOLOGY, May 2013, 33(4):489 - 501, Refereed

Cilostazol Strengthens Barrier Integrity in Brain Endothelial Cells
Shoji Horai; Shinsuke Nakagawa; Kunihiko Tanaka; Yoichi Morofuji; Pierre-Oliver Couraud; Maria A. Deli; Masaki Ozawa; Masami Niwa
CELLULAR AND MOLECULAR NEUROBIOLOGY, Mar. 2013, 33(2):291 - 307, Refereed

Infection of human pericytes by HIV-1 disrupts the integrity of the blood-brain barrier
Shinsuke Nakagawa; Victor Castro; Michal Toborek
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, Dec. 2012, 16(12):2950 - 2957, Refereed

Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood-brain barrier penetration models
Eve Hellinger; Szilvia Veszelka; Andrea E. Toth; Fruzsina Walter; Agnes Kittel; Monika Laura Bakk; Karoly Tihanyi; Viktor Hada; Shinsuke Nakagawa; Thuy Dinh Ha Duy; Masami Niwa; Maria A. Deli; Monika Vastag
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Oct. 2012, 82(2):340 - 351, Refereed

Patented in vitro blood-brain barrier models in CNS drug discovery
Andrea Tóth; Szilvia Veszelka; Shinsuke Nakagawa; Masami Niwa; Mária A. Deli
Recent Patents on CNS Drug Discovery, May 2011, 6(2):107 - 118, Refereed

Transient expression of iron transport proteins in the capillary of the developing rat brain.
Yang WM; Jung KJ; Lee MO; Lee YS; Lee YH; Nakagawa S; Niwa M; Cho SS; Kim DW
Cellular and Molecular Neurobiology., Jan. 2011, 31(1):727 - 735, Refereed

Pitavastatin Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells
Yoichi Morofuji; Shinsuke Nakagawa; Gohei So; Takeshi Hiu; Shoji Horai; Kentaro Hayashi; Kunihiko Tanaka; Kazuhiko Suyama; Maria A. Deli; Izumi Nagata; Masami Niwa
CELLULAR AND MOLECULAR NEUROBIOLOGY, Jul. 2010, 30(5):727 - 735

Development of a Novel Cell-based Assay to Evaluate the Malignant Potential of Cancer In Vitro
Chiasa Hirakawa; Kunihiko Tanaka; Yoshihiro Takaya; Shinsuke Nakagawa; Yasufumi Kataoka; Yutaka Tagawa; Masami Niwa
ANTICANCER RESEARCH, Jul. 2009, 29(7):2541 - 2545

Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood-Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice
Tsuyoshi Nishioku; Shinya Dohgu; Fuyuko Takata; Tomoaki Eto; Naoko Ishikawa; Kota B. Kodama; Shinsuke Nakagawa; Atsushi Yamauchi; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, May 2009, 29(3):309 - 316, Refereed

A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes
Shinsuke Nakagawa; Maria A. Deli; Hiroko Kawaguchi; Takeshi Shimizudani; Takanori Shimono; Agnes Kittel; Kunihiko Tanaka; Masami Niwa
NEUROCHEMISTRY INTERNATIONAL, Mar. 2009, 54(3-4):253 - 263

Effect of pitavastatin on the blood-brain barrier (BBB) in vitro
Yoichi Morofuji; Shinsuke Nakagawa; Shoji Horai; Tkanori Shimono; Kentaro Hayashi; Maria Deli; Izumi Nagata; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109:94P - 94P, Refereed

Effect of cilostazol on blood-brain barrier (BBB) functions in vitro
Shoji Horai; Shinsuke Nakagawa; Youichi Morofuji; Tkanori Shimono; Maria Deli; Hiroki Ozawa; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109:93P - 93P, Refereed

DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats
Shin Miyazaki; Takashi Yanagida; Kana Nunome; Shizuma Ishikawa; Masatoshi Inden; Yoshihisa Kitamura; Shinsuke Nakagawa; Takahiro Taira; Kosaku Hirota; Masami Niwa; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
JOURNAL OF NEUROCHEMISTRY, Jun. 2008, 105(6):2418 - 2434, Refereed

Adverse effect of cyclosporin a on barrier functions of cerebral microvascular endothelial cells after hypoxia-reoxygenation damage in vitro
Shinya Dohgu; Tsuyoshi Nishioku; Noriko Sumi; Fuyuko Takata; Shinsuke Nakagawa; Mikihiko Naito; Takashi Tsuruo; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, Nov. 2007, 27(7):889 - 899, Refereed

Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells
Shinsuke Nakagawa; Maria A. Deli; Shinobu Nakao; Masaru Honda; Kentaro Hayashi; Ryota Nakaoke; Yasufumi Kataoka; Masami Niwa
CELLULAR AND MOLECULAR NEUROBIOLOGY, Sep. 2007, 27(6):687 - 694, Refereed

Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier
Fuyuko Takata; Shinya Dohgu; Atsushi Yamauchi; Noriko Sumi; Shinsuke Nakagawa; Mikihiko Naito; Takashi Tsuruo; Hideki Shuto; Yasufumi Kataoka
CELLULAR AND MOLECULAR NEUROBIOLOGY, May 2007, 27(3):317 - 328, Refereed

Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5
M Honda; S Nakagawa; K Hayashi; N Kitagawa; K Tsutsumi; Nagata, I; M Niwa
CELLULAR AND MOLECULAR NEUROBIOLOGY, Mar. 2006, 26(2):109 - 118, Refereed

Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production
S Dohgu; F Takata; A Yamauchi; S Nakagawa; T Egawa; M Naito; T Tsuruo; Y Sawada; M Niwa; Y Kataoka
BRAIN RESEARCH, Mar. 2005, 1038(2):208 - 215, Refereed

Effects of hypoxia on endothelial/pericytic co-culture model of the blood-brain barrier
K Hayashi; S Nakao; R Nakaoke; S Nakagawa; N Kitagawa; M Niwa
REGULATORY PEPTIDES, Dec. 2004, 123(1-3):77 - 83, Refereed

Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes
S Dohgu; A Yamauchi; S Nakagawa; F Takata; M Kai; T Egawa; M Naito; T Tsuruo; Y Sawada; M Niwa; Y Kataoka
EUROPEAN JOURNAL OF PHARMACOLOGY, Nov. 2004, 505(1-3):51 - 59, Refereed

Contrast media increase vascular endothelial permeability by inhibiting nitric-oxide production
W Furuta; A Yamauchi; S Dohgu; S Nakagawa; T Sendo; K Makino; R Oishi; Y Kataoka
INVESTIGATIVE RADIOLOGY, Jan. 2002, 37(1):13 - 19, Refereed

急性期脳梗塞治療としてのファスジル動注療法の可能性
諸藤陽一; 中川慎介; 藤本隆史; 佐藤慧; 松永裕希; 堀江信貴; 出雲剛; 松尾孝之
脳血管内治療(Web), 2020, 5(Supplement)

Industrial Info. in vitro血液脳関門再構成モデル「BBBキット」を用いた薬理学的研究
渡邉 大祐; 中川 慎介; 蓬莱 彰士; 丹羽 正美
細胞, Aug. 2016, 48(8):400 - 402

実験技術 脳毛細血管のin vitroでの再現 血液脳関門(BBB)構成細胞の単離とin vitro BBBモデルの再構築
中川 慎介; 丹羽 正美
日本薬理学雑誌, Mar. 2014, 143(3):137 - 143

[Isolation of cells constituting the blood-brain barrier and reconstruction of the in vitro BBB model].
Nakagawa S; Niwa M
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Mar. 2014, 143(3):137 - 143, Refereed

Effect of HGF and TGF-beta on barrier functions in rat brain capillary endothelial cells
Shinsuke Nakagawa; Narumi Yamada; Tomonori Takeshita; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124:190P - 190P

血液脳関門 血液脳関門in vitro再構成モデル(BBBキット)と機能解明への活用
中川 慎介; Deli Maria A; Thuy Dinh Ha Duy; 相良 真由美; 田中 邦彦; 丹羽 正美
脳循環代謝, Jul. 2013, 24(2):71 - 74

Cilostazol protects the BBB against AGE-related ischemia via TGF-beta signaling
Shinsuke Nakagawa; Tomonori Takeshita; Thuy Dhin; Rie Tatsumi; Kentaro Hayashi; Kunihiko Tanaka; Izumi Nagata; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121:219P - 219P

Blood-brain barrier as a tumor microenvironment
Kunihiko Tanaka; Keisuke Toyoda; Shinsuke Nakagawa; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121:25P - 25P

Infection of human pericytes by HIV-1 disrupts the integrity of the blood-brain barrier
Michal Toborek; Shinsuke Nakagawa
FASEB JOURNAL, Apr. 2012, 26

Cilostazol rescues the BBB from AGE-related Ischemic insult
Tomonori Takeshita; Rie Tatsumi; Shinsuke Nakagawa; Nobutaka Horie; Kentaro Hayashi; Kazuhiko Suyama; Kunihiko Tanaka; Izumi Nagata; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118:142P - 142P

The effects of candesartan on the blood-brain barrier
Gohei So; Shinsuke Nakagawa; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:141P - 141P

Comparison between in vitro-BBB effects of HGF and TGF-beta
Narumi Yamada; Shinsuke Nakagawa; Gohei So; Thuy Dinh Ha Duy; Rie Tatsumi; Kunihiko Tanaka; Maria A. Deli; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:200P - 200P

Pituitary adenylate cyclase activating polypeptide (PACAP) enhances blood-brain barrier (BBB) functions of rat brain microvascular endothelial cells in vitro
Shinsuke Nakagawa; Kenzou Hazama; Shoji Horai; Narumi Yamada; Yasufumi Kataoka; Maria A. Deli; Masami Niwa
JOURNAL OF MOLECULAR NEUROSCIENCE, Nov. 2010, 42(3):303 - 303

【血液脳関門 分子機序から病態まで】 血液脳関門再構成モデルと機能解明への活用
中川 慎介; 田中 邦彦; 田川 泰; 丹羽 正美
分子脳血管病, Jul. 2010, 9(3):265 - 273

Development of ready-to-use 24-well type BBB Kit (TM)
Shinsuke Nakagawa; Maria Deli; Thuy Dinh; Mayumi Sagara; Narumi Yamada; Kunihiko Tanaka; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:189P - 189P

Evaluation of the brain metastatic potency of cancer cells with BBB Kit
Kunihiko Tanaka; Shinsuke Nakagawa; Yutaka Tagawa; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:120P - 120P

Development of in vitro monkey BBB model
Shinsuke Nakagawa; Maria Deli; Thuy Dinh; Mayumi Sagara; Narumi Yamada; Kunihiko Tanaka; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:91P - 91P

血液－脳関門透過性に対して薬物乱用が及ぼす影響の in vitro 評価
池田理恵; 和田光弘; 中川慎介; 丹羽正美; 中島憲一郎
日本臨床化学会九州支部会誌, 2010, 20:10 - 11, Refereed

カンデサルタンが血液脳関門に与える影響と脳梗塞治療への応用の可能性
宗剛平; 中川慎介; 諸藤陽一; 林健太郎; 陶山一彦; 永田泉; 丹羽正美
脳循環代謝, Nov. 2009, 21(1):147 - 147

血液脳関門に対するシロスタゾールの作用
蓬莱彰士; 中川慎介; 諸藤陽一; 下野貴宣; 片岡泰文; DELI Maria A; 小澤寛樹; 丹羽正美
日本薬理学会西南部会プログラム/抄録集, Mar. 2009, 133(3):35P - 35P

スタチン(HMG-CoA還元酵素阻害薬)が血液脳関門(blood-brain barrier)に与える影響
諸藤陽一; 中川慎介; 蓬莱彰士; 林健太郎; 北川直毅; 陶山一彦; 永田泉; 丹羽正美
日本薬理学会西南部会プログラム/抄録集, Mar. 2009, 133(3):35P - 35P

キーワード解説 血液脳関門(BBB)
中川 慎介; 丹羽 正美
日本薬理学雑誌, Mar. 2009, 133(3):170 - 172

[Blood-Brain Barrier (BBB)].
Nakagawa S; Niwa M
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Mar. 2009, 133(3):170 - 172, Refereed

Functional impact of RIMs on gating of voltage-dependent Ca2+channels
Junichi Matsumoto; Noriko Sumi; Tsuyoshi Nishioku; Shinya Dohgu; Shinsuke Nakagawa; Atsushi Yamauchi; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109:159P - 159P

Tissue Plasminogen Activator Enhances the Hypoxia/reoxygenation-induced Impairment of the Blood-brain Barrier in a Primary Culture of Rat Brain Endothelial Cells
Takeshi Hiu; Sinsuke Nakagawa; Kentaro Hayashi; Naoki Kitagawa; Keisuke Tsutsumi; Junichi Kawakubo; Masaru Honda; Kazuhiko Suyama; Izumi Nagata; Masami Niwa
CELLULAR AND MOLECULAR NEUROBIOLOGY, Dec. 2008, 28(8):1139 - 1146

tPAの血液脳関門に与える影響 in vitro虚血モデルを用いて
日宇健; 中川慎介; 林健太郎; 諸藤陽一; 北川直毅; 堤圭介; 陶山一彦; 永田泉; 丹羽正美
脳循環代謝, Nov. 2008, 20(1):156 - 156

スタチン(HMG-CoA還元酵素阻害薬)が血液脳関門(BBB)に与える影響
諸藤陽一; 中川慎介; 蓬莱彰士; 林健太郎; 北川直毅; 陶山一彦; 永田泉; 丹羽正美
日本脳神経外科学会総会抄録集(CD-ROM), Oct. 2008, 67回:2J - 07

血液脳関門 in vitro 再構成モデル
中川 慎介; 丹羽 正美
日本薬理学雑誌, 01 May 2008, 131(5):392 - 393

最近の話題 血液脳関門in vitro再構成モデル
中川 慎介; 丹羽 正美
日本薬理学雑誌, May 2008, 131(5):392 - 393

アドレノメデュリンによる脳血管周皮細胞ペリサイトの弛緩作用 脳微細循環調節機構の解明を目指して
原田 枝理子; 高田 芙友子; 湧川 朝也; 西奥 剛; 角 典子; 児玉 耕太; 山内 淳史; 中川 慎介; 首藤 英樹; 丹羽 正美; 片岡 泰文
日本薬理学雑誌, Mar. 2008, 131(3):48p - 48p

tPAの血液脳関門に与える影響 in vitro虚血モデルを用いて
日宇健; 中川慎介; 林健太郎; 北川直毅; 堤圭介; 諸藤陽一; 陶山一彦; 永田泉; 丹羽正美
脳卒中, Mar. 2008, 30(2):360 - 360

Involvement of the activated microglia in the induction of blood-brain barrier dysfunction
Noriko Sumi; Tsuyoshi Nishioku; Kotoe Asano; Junichi Matsumoto; Shinsuke Nakagawa; Atsushi Yamauchi; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:126P - 126P

Time-course of morphological alterations of pericytes in the blood-brain barrier disruption
Naoko Ishikawa; Tsuyoshi Nishioku; Noriko Sumi; Hiromi Nakanishi; Atsushi Yamauchi; Shinsuke Nakagawa; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:127P - 127P

Tissue plasminogen activator enhances an increase in permeability of blood-brain barrier during hypoxic condition in vitro
Takeshi Hiu; Shinsuke Nakagawa; Kentaro Hayashi; Naoki Kitagawa; Youichi Morofuji; Izumi Nagata; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:109P - 109P

A new BBB model: testing specific functions
Shinsuke Nakagawa; A. Maria Deli; Hiroko Kawaguchi; Takeshi Shimizudani; Takanori Shimono; Makiko Yamaguchi; Yasufumi Kataoka; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:235P - 235P

Involvement of brain pericytes in tacrolimus (TCL)-induced dysfunction of the blood-brain barrier (BBB)
Fuyuko Takata; Eriko Harada; Shinsuke Nakagawa; Tomoya Wakigawa; Sachiyo Hashiguchi; Atsushi Yamauchi; Hideki Shuto; Maria A. Deli; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:51P - 51P

The comprehensive expression analysis of claudin family, in heterogenous clones from cultured human colon cancer cell line
Yoshihiro Takaya; Kunihiko Tanaka; Shinsuke Nakagawa; Yasuko Yamashita; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:104P - 104P

血液脳関門 (Blood-brain barrier) in vitro 再構成系モデルの開発
中川慎介; 丹羽正美
バイオインダストリー, 2008, 25(8):73 - 82

血液脳関門を通過するための通行手形を見つけるために
中川慎介; 丹羽正美
ファルマシア, 2008, 44(99):900 - 900

Protective effect of adrenomedullin on lipopolysaccharide-induced blood-brain barrier dysfunction
Noriko Sumi; Tsuyoshi Nishioku; Fuyuko Takata; Atsushi Yamauchi; Shinsuke Nakagawa; Maria A. Deli; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103:178P - 178P

Relaxation of cultured rat brain pericytes after stimulation with adrenomedullin
Hiroyuki Takahashi; Fuyuko Takata; Tsuyoshi Nishioku; Atsushi Yamauchi; Noriko Sumi; Shinsuke Nakagawa; Maria A. Deli; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103:178P - 178P

BBB kit: Blood-brain-barrier in vitro reconstruction model
Shinsuke Nakagawa; Maria A. Dell; Shinobu Nakao-Nishioku; Kentaro Hayashi; Ryota Nakaoke; Yasufumi Kataoka; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103:57P - 57P

Involvement of microglia in the induction of blood-brain barrier dysfunction
Kenji Miyao; Tsuyoshi Nishioku; Fuyuko Takata; Noriko Sumi; Atsushi Yamauchi; Shinsuke Nakagawa; Maria A. Deli; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103:177P - 177P

Significance of the transepithelial electrical resistance (TEER) measurement on cancer cells.
Kunihiko Tanaka; Yoshihiro Takaya; Shinsuke Nakagawa; Yutaka Tagawa; Masami Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103:159P - 159P

Evaluation of pentosan polysulfate for the permeability of blood-brain barrier
M Hagihara; H Shuto; F Takata; S Shirabe; S Nakagawa; MA Deli; M Niwa; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 100:200P - 200P

Regulation of the blood brain barrier function with 17 beta-estradiol
C Hirakawa; F Takata; H Shuto; S Nakagawa; MA Deli; M Niwa; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 100:202P - 202P

Effect of pituitary adenylate cyclase activating polypeptide (PACAP) on the tight junctions of the blood-brain barrier (BBB)
K Hazama; S Nakagawa; K Tanaka; F Takata; MA Deli; Y Kataoka; M Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 100:85P - 85P

Hepatocyte growth factor (HGF) enhances barrier function of the blood-brain barrier (BBB)
S Nakagawa; K Hazama; K Tanaka; S Dohgu; F Takata; MA Deli; Y Kataoka; M Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 100:203P - 203P

【グリア細胞 その新しい展開】 グリア細胞と脳疾患 脳虚血
丹羽 正美; 山下 康子; 中川 慎介
Clinical Neuroscience, Feb. 2005, 23(2):212 - 215

Expression of tight junction proteins (TJs) as adhesion structure in endothelial/epithelial cells and transendothelial electrical resistance (TEER)
S Nakagawa; K Tanaka; Y Takaya; S Dohgu; Y Kataoka; MA Deli; M Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, 97:131P - 131P

The brain pericyte-derived transforming growth factor-beta (TGF-beta) upregulates the blood-brain barrier function
F Takata; S Dohgu; A Yamauchi; N Sumi; S Nakagawa; M Niwa; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, 97:213P - 213P

Cyclosporin A induces dysfunction of the blood-brain barrier by inhibiting adrenomedullin signal transduction in mouse brain endothelial cells
N Sumi; S Dohgu; A Yamauchi; F Takata; S Nakagawa; M Niwa; Y Kataoka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, 97:213P - 213P

【脳浮腫の基礎と臨床 最新の研究から】 血液脳関門の構造と機能
中川 慎介; 丹羽 正美
ICUとCCU, Jul. 2004, 28(7):471 - 483

An in vitro model of the blood-brain barrier with human peripheral microvascular endothelial cells
S Nakagawa; S Dohgu; Y Kataoka; M Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94:287P - 287P

Effects of cocultured pericytes on the blood-brain barrier (BBB) functions in vitro BBB models
S Nakagawa; S Nakao; MA Deli; Y Kataoka; S Katamine; M Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94:89P - 89P

Pentosan polysulphate strengthens blood-brain barrier (BBB) functions in vitro.
S Nakao; R Nakaoke; S Nakagawa; Y Yamashita; Y Kataoka; S Katamine; M Niwa
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, 91:221P - 221P

薬物の脳内移行検定システムの開発:血液脳関門in vitro再構築系(BBBキット)
中桶 了太; 中尾 しのぶ; 林 健太郎; 中川 慎介; 片岡 泰文; 丹羽 正美
応用薬理, Aug. 2002, 62(4):68 - 71

Establishment of in vitro human blood-brain barrier (BBB) model with human peripheral microvessel Endothelial cells (HMVEC)
S Nakagawa; S Dohgu; A Yamauchi; M Niwa; Y Kataoka; R Oishi
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, 88:283P - 283P

造影剤イオキサグレートによる血管内皮細胞透過性高進における一酸化窒素の役割
古田 和歌子; 中川 慎介; 千堂 年昭; 片岡 泰文; 大石 了三
日本薬理学雑誌, Mar. 2001, 117(3):71P - 71P

造影剤による血管内皮細胞透過性亢進における一酸化窒素の役割
古田 和歌子; 中川 慎介; 住村 智子; 千堂 年昭; 片岡 泰文; 大石 了三
日本薬学会年会要旨集, Mar. 2001, 121年会(3):79 - 79

モデル動物の作製と利用－循環器疾患2021 ＜下巻＞
Others, 第Ⅳ部 第2章 第６節 In vitro 血液脳関門（Blood-brain barrier, BBB）モデル
株式会社エル・アイ・シー, 24 Dec. 2021

Biology of Pericytes – Recent Advances
Yoichi Morofuji; Shinsuke Nakagawa; Takashi Fujimoto; Susumu Yamaguchi; Kenta Ujifuku; Takayuki Matsuo, Others, Role of Pericytes in Brain Metastasis.
Humana Press, 2021

The Neurology of AIDS, Third Edition
Michal Toborek; Ibolya E. Andras; Cetewayo S. Rashid; Yu Zhong; Nakagawa S, Others, 3.2. Endothelial cell biology and HIV-1 infection
Oxford university press, 01 Dec. 2011

脳卒中易発症性高血圧自然発症ラット（SHRSP）由来in vitro BBB モデルの再構築と機能評価
中川慎介; 大原浩貴; 有賀純; 丹羽正美; 山形一雄; 並河徹
第93回日本薬理学会年会, 16 Mar. 2020

脳虚血再灌流障害に対するプロブコールの保護作用とSphingosine-1-phosphateの関与
中川 慎介; 有賀 純
第29回日本循環薬理学会 第55回高血圧関連疾患モデル学会合同学会, 29 Nov. 2019

重症くも膜下出血における early brain injury に寄与する遺伝子について
荒井 信彦; 高橋 里史; 小池 一成; 水谷 克洋; 中川 慎介; 秋山 武記; 堀口 崇; 吉田 一成
第62回日本脳循環代謝学会学術集会, 29 Nov. 2019

血液脳関門機能を調節するペリサイトへのスフィンゴシ-1-リン酸の作用.
中川 慎介; 有賀 純
第92回薬理学会年会, 14 Mar. 2019

血液脳関門機能を調節するペリサイトへのスフィンゴシ-1-リン酸の作用
中川 慎介; 有賀 純
第92回薬理学会年会, Mar. 2019

血液脳関門in vitroモデル及び中枢神経疾患治療薬の開発
諸藤 陽一; 中川 慎介; 藤本 隆史; 佐藤 慧; 堀江 信貴; 出雲 剛; 案田 岳夫; William A. Banks; 松尾 孝之
日本脳神経外科学会第77回学術総会, Oct. 2018

Role of Pericytes in brain metastasis formation.
Takashi Fujimoto; Yoichi Morofuji; Daisuke Watanabe; Shinsuke Nakagawa; Kenta Ujifuku; Tsuyoshi Izumo; Takeo Anda; Takayuki Matsuo
Sep. 2018

Roles of sphingosine 1-phosphate in blood-brain barrier using in vitro and in vivo ischemia-reperfusion injury model.
NAKAGAWA Shinsuke
18th World Congress of Basic and Clinical Pharmacology, Jul. 2018

新しく開発したハイスループットスクリーニングアッセイが同定したベルベリンの血液脳関門保護薬としての可能性
鈴木 裕貴; 角家 健; 中川 慎介; 遠藤 健; Takeshi Endo; 松居 祐樹; 袁 儒非; 浅野 毅; 岩崎 倫政
第41回日本神経科学大会, Jul. 2018

WKY/IzmとSHRSP/Izmの血液脳関門機能比較：In vitro BBBモデルを用いた検討
中川慎介; 大原浩貴; 有賀純; 山形一雄; 並河徹
第53回高血圧関連疾患モデル学会, 24 Nov. 2017

血液脳関門の成り立ちとその病態
中川慎介
第122回日本解剖学会総会・学術集会, 28 Mar. 2017

血液脳関門の虚血再灌流障害におけるスフィンゴシン1-リン酸の役割
中川慎介; 有賀純
第90回薬理学会年会, 15 Mar. 2017

創薬支援ツールBBBキットの大学発ベンチャー起業
丹羽正美; 中川慎介; 渡邊大祐
第90回薬理学会年会, 15 Mar. 2017

スフィンゴシン1-リン酸経路の抑制は虚血再灌流による血液脳関門機能障害を軽減する
中川慎介; 有賀純
Stroke 2016, 14 Apr. 2016

がんの脳転移機序と血液脳関門（BBB）の関連性の検討
藤本 隆史; 諸藤 陽一; 中川 慎介; 佐藤 慧; 氏福 健太; 出雲 剛; 案田 岳夫; 松尾 孝之
日本脳神経外科学会第77回学術総会, 10 Oct. 2010

BBBキットを用いた脳転移能の評価
第83回日本薬理学会年会, 2010

Evaluation of the brain metastatic potency of cancer cells with BBB Kit
2010

BBBキットを用いた肺癌細胞の脳転移能評価
第62回日本薬理学会西南部会, 2009

BBBキットによる肺癌脳転移能の評価
第68回日本癌学会学術総会, 2009

Evaluation of the brain metastatic potencies of lung cancer cells with BBB Kit
8th Cerebral Vascular Biology International Conference, 2009

Evaluation of the brain metastatic potency of lung cancer cells using BBB Kit
2009

Evaluation of the brain metastatic potency of lung cancer with BBB Kit
2009

Evaluation of the brain metastatic potencies of lung cancer cells with BBB Kit
2009

Hepatocyte Growth Factor (HGF) Enhances Barrier Function of Rat Brain Microvascular Endothelial Cells
The sixth Cerebral Vascular Biology 2005, 2005

GENETIC HYPERTENSION-RELATED BBB DYSFUNCTION
The seventh symposium on "Signal Transduction in the Blood-Brain Barriers", 2004

Esterblishment of in vitro human blood-brain barrier (BBB) model with human
The sixth symposium on "Signal Transduction in the Blood-Brain Barriers", 2003

薬理学
長崎大学 医学部

THE JAPANESE PHARMACOLOGICAL SOCIETY

Society for Hypertension Related Disease Model Research

The Japanese Society of Cerebral Blood Flow and Metabolism

THE JAPANESE SOCIETY FOR NEUROCHEMISTRY

THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

分子標的薬による血液脳関門機能障害の発症機序解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2024 - 31 Mar. 2027

新規肺特異的疑似毛細血管壁モデルによるARDS病態解明と治療開発
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
長崎大学
01 Apr. 2022 - 31 Mar. 2026

灌流型3次元血液脳関門モデルを用いた中枢神経系疾患治療薬の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Nagasaki University
27 Oct. 2020 - 31 Mar. 2026

血液脳関門モデルを用いた造影剤脳症の作用機序解明と治療法探求
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
長崎大学
01 Apr. 2022 - 31 Mar. 2025

アンドロゲンを核とする内分泌系－肺－脳の臓器連関異常化によるCOPD病態増悪機構
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2021 - 31 Mar. 2024

ドラッグリポジショニングによる中枢神経疾患治療薬の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
Nagasaki University
01 Apr. 2020 - 31 Mar. 2023

VCP化合物の最適化による新規神経保護薬の開発
日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
北海道大学
01 Apr. 2020 - 31 Mar. 2023

脳ペリサイトの機能変化による細胞間クロストーク異常と脳血管障害の進展
日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
長崎大学
01 Apr. 2020 - 31 Mar. 2023

Rho kinase阻害薬fasudilが血液脳関門に与える影響とメカニズム解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
Nagasaki University
01 Apr. 2019 - 31 Mar. 2022

Rho kinase阻害薬fasudilが血液脳関門に与える影響とメカニズム解明
基盤研究 (C)
Apr. 2019 - Mar. 2021

脊髄損傷に対する新規神経保護薬の開発、研究代表者
基盤研究 (C)
Apr. 2017 - Mar. 2019

脊髄損傷に対する新規神経保護薬の開発
基盤研究（C）
2017 - 2019

リゾリン脂質制御に基づく新規脳血管保護法の開発
基盤研究（C）
2017 - 2019

遺伝的脳卒中モデルラットの血液脳関門は脆弱かーインビトロ再構築技術を用いた検討
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
Nihon University
01 Apr. 2015 - 31 Mar. 2018

Zicファミリーによる血管再生制御技術の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research
Nagasaki University
01 Apr. 2015 - 31 Mar. 2017

スフィンゴシン１リン酸による血液能関門（BBB）機能制御の解明
基盤研究（C）
2014 - 2016

実験的脳虚血病態における血液脳関門（ＢＢＢ）構成細胞の相互作用解析
若手研究(B)
2012 - 2013

中枢神経作用薬の創薬スクリーニング系としての血液脳関門再構成系病態モデルの確立
基盤研究 (C)
Apr. 2010 - Mar. 2012

病態血液脳関門におけるペリサイトの役割解明
若手研究 (B)
2009 - 2010

中枢神経作用薬の創薬スクリーニング系としての血液脳関門再構成系病態モデルの確立
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
Nagasaki University
2006 - 2007

レーザー細胞破壊技術を用いた寄生蠕虫感染型幼虫の特殊細胞・器官の機能と役割の検証
日本学術振興会, 科学研究費助成事業 萌芽研究, 萌芽研究
長崎大学
2006 - 2007

-

WO2016-148213, JP2016058406, 血液脳関門透過性ペプチド
武内 敏秀, 永井 義隆, 中川 慎介, 丹羽 正美, 道具 伸也, 片岡 泰文, 高田 芙友子

特許第5113332号, 特開2007-166915, 特願2005-364636, 血液脳関門インヴィトロ・モデル、病態血液脳関門インヴィトロ・モデル、及びこれを用いた薬物スクリーニング方法、病態血液脳関門機能解析方法、病因解析方法
デリ, アンナ, マリア, 中川 慎介, 丹羽 正美

特許第5105905号, 特開2008-212062, 特願2007-054326, 複数種類の細胞の立体的な配置の凍結保存方法及び凍結保存細胞の解凍方法
中川 慎介, 下野 貴宣