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Last Updated :2026/04/05

Ryota Tsuchihashi
Department of Phatmaceutics
Lecturer/Senior Assistant Professor
Research activity information
■ Award
■ Paper
■ Industrial Property Rights
■ Paper
- Two New Triterpene Glycosides in the Roots of Uraria crinita
KINJO Junei; OKAWA Masafumi
Chem Pharm Bull, Feb. 2019, 67(2):159 - 162, Refereed - Seven new resin glycosides from the seeds of Quamoclit × multifida
KINJO Junei; TSUCHIHASHI Ryota; OKAWA Masafumi
J Nat Med, Jan. 2019, 72(3):11 - 22, Refereed - Role of vasopressin V1a receptor in ∆9-tetrahydrocannabinol-induced cataleptic immobilization in mice
KINJO Junei; TSUCHIHASHI Ryota
Psychopharmacology, 2017, 2017:3475 - 3483, Refereed - Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (IV): phenanthroindolizidine alkaloids from Tylophora tanakae leaves
NAKANO Daisuke; TSUCHIHASHI Ryota; OKAWA Masafumi; KINJO Junei
J Nat Med, 2015, 69(3):397 - 401, Refereed - Analysis of Seasonal Variation in the Amounts of Phytochemicals in Kudzu (Pueraria lobata) Leaves Using HPLC with Evaporative Light Scattering Detection
TSUCHIHASHI Ryota; NAKANO Daisuke; OKAWA Masafumi; KINJO Junei
International Journal of Plant Biology and Research, 2015, 3(1):397 - 401, Refereed - Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (III)
KINJO Junei; NAKANO Daisuke; TSUCHIHASHI Ryota; OKAWA Masafumi
J Nat Med, Sep. 2013, 67(4):894 - 903 - Screening of chemotherapeutic candidates from plants against ATL (II): apoptosis of antiproliferactive principle (24,25-dihydrowithanolide D) and structure-activity relationships with withanolides isolated from solanaceous plants
KINJO Junei; NAKANO Daisuke; OKAWA Masafumi; TSUCHIHASHI Ryota
J Nat Med., Feb. 2013, 67(2):415 - 420, Refereed - 腸内細菌による配糖体の加水分解と代謝活性化
KINJO Junei; TSUCHIHASHI Ryota
腸内細菌学雑誌, Nov. 2012, 26(11):223 - 233, Refereed - Screening of promising chemotherapeutic candidates against human adult T-cell leukemia/lymphoma from plants: active principles from Physalis pruinosa and structure-activity relationships with withanolides.
NAKANO Daisuke; ISHITSUKA KENJI; TSUCHIHASHI Ryota; OKAWA Masafumi; TAMURA Kazuo; KINJO Junei
J Nat Med., Jul. 2011, 65(3-4):559 - 567, Refereed - Development of an enzyme-linked immunosorbent assay to determine puerarin and its aglycone daidzein
B. Pongkitwitoon; S. Sakamoto; H. Tanaka; TSUCHIHASHI Ryota; KINJO Junei; S. Morimoto; W. Putalun
J. Nat. Med., Feb. 2011, 65(1):31 - 36, Refereed - Expression, Purification, and Characterization of Anti-Plumbagin Single-Chain Variable Fragment Antibody in Sf9 Insect Cell
Seiichi Sakamoto; Futoshi Taura; Ryota Tsuchihashi; Waraporn Putalun; Junei Kinjo; Hiroyuki Tanaka; Satoshi Morimoto
HYBRIDOMA, Dec. 2010, 29(6):481 - 488, Refereed - Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside
Niiho Y; Nakajima Y; Yamazaki T; Okamoto M; Tsuchihashi R; Kodera M; Kinjo J; Nohara T
Journal of Natural Medicines, Jun. 2010, 64(3):313 - 320, Refereed - Enzyme-Linked Immunosorbent Assay for Total Isoflavonoids in Pueraria candollei Using Anti-Puerarin and Anti-Daidzin Polyclonal Antibodies
Benyakan Pongkitwitoon; Seiichi Sakamoto; Hiroyuki Tanaka; Ryota Tsuchihashi; Junei Kinjo; Satoshi Morimoto; Waraporn Putalun
PLANTA MEDICA, May 2010, 76(8):831 - 836, Refereed - Development of sensitivity-improved fluorescence-linked immunosorbent assay using a fluorescent single-domain antibody against the bioactive naphthoquinone, plumbagin
Seiichi Sakamoto; Futoshi Taura; Benyakan Pongkitwitoon; Waraporn Putalun; Ryota Tsuchihashi; Junei Kinjo; Hiroyuki Tanaka; Satoshi Morimoto
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Apr. 2010, 396(8):2955 - 2963, Refereed - Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress
Sano K; Koushi E; Irie K; Higuchi S; Tsuchihashi R; Kinjo J; Egashira N; Oishi R; Uchida N; Nagai H; Nishimura R; Tanaka H; Morimoto S; Mishima K; Iwasaki K; Fujiwara M
Biol Pharm Bull., Dec. 2009, 32(12):2065 - 2067, Refereed - Three new diterpenoids from the fruit of Vitex agnus-castus
Ono M; Nagasawa Y; Ikeda T; Tsuchihashi R; Okawa M; Kinjo J; Yoshimitsu H; Nohara T
Chem Pharm Bull, Oct. 2009, 57(10):1132 - 1135 - Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains
Ryota Tsuchihashi; Mitsuru Kodera; Seiichi Sakamoto; Yoshijiro Nakajima; Takashi Yamazaki; Yujiro Niiho; Toshihiro Nohara; Junei Kinjo
JOURNAL OF NATURAL MEDICINES, Jul. 2009, 63(3):254 - 260, Refereed - Construction and expression of specificity-improved single-chain variable fragments against the bioactive naphthoquinone, plumbagin.
Sakamoto S; Taura F; Putalun W; Pongkitwitoon B; Tsuchihashi R; Morimoto S; Kinjo J; Shoyama Y; Tanaka H
Biol Pharm Bull., Mar. 2009, 32(3):434 - 439, Refereed - Microbial metabolism of soy isoflavones by human intestinal bacterial strains
Ryota Tsuchihashi; Seiichi Sakamoto; Mitsuru Kodera; Toshihiro Nohara; Junei Kinjo
Journal of Natural Medicines, Sep. 2008, 62(4):456 - 460, Refereed - Three New Monoterpenoids from the Fruit of Genipa americana
M.Ono; N. Ishimatsu; C. Masuoka; H. Yoshimitsu; R. Tsuchihashi; M. Okawa; J. Kinjo; T. Ikeda; T. Nohara
Chem. Pharm. Bull., Apr. 2007, 55(4):632 - 634, Refereed - Hepatoprotective Constituents in Plants 15. Protective Effects of Natural-Occurring Flavonoids and Miscellaneous Phenolic Compounds on an HepG2 Cell Cytotoxicity Assay
J. Kinjo; M. Hitoshi; R. Tsuchihashi; Y. Korematsu; M. Miyakoshi; T. Murakami; D. Araho; K. Mizutani; T. Tanaka; G. Nonaka; T. Nohara; M. Okawa; H. Okabe
Journal of Natural Medicines, Jan. 2006, 60(1):36 - 41, Refereed - Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica
Miyako YOSHIDA; Masahiro FUCHIGAMI; Tsuneatsu NAGAO; Hikaru OKABE; Kazuhisa MATSUNAGA; Jiro TAKATA; Yoshiharu KARUBE; Ryota TSUCHIHASHI; Junei KINJO; Kunihide MIHASHI; Toshihiro FUJIOKA
Biol. Pharm. Bull., Jan. 2005, 28(1):173 - 175, Refereed - Antiproliferative constituents from umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica
Miyako Yoshida; Masahiro Fuchigami; Tsuneatsu Nagao; Hikaru Okabe; Kazuhisa Matsunaga; Jiro Takata; Yoshiharu Karube; Ryota Tsuchihashi; Junei Kinjo; Kunihide Mihashi; Toshihiro Fujioka
Biological and Pharmaceutical Bulletin, 2005, 28(1):173 - 175, Refereed - Soy Isoflavone Metabolites Isolated from Human Urine
TSUCHIHASHI Ryota; KINJO Junei
Natural Medicines, Apr. 2004, 58(2):71 - 75, Refereed - Interactions of Phytoestrogens with Estrogen Receptors a and b (III). Estrogenic Activities of Soy Isoflavone Aglycones and Their Metabolites Isolated from Human Urine
KINJO Junei; TSUCHIHASHI Ryota
Biol. Pharm. Bull., Feb. 2004, 27(2):185 - 188, Refereed - HPLC Profile Analysis of Hepatoprotective Oleanene-Glucuronides in Several Soybean Processed Foods
TSUCHIHASHI Ryota; KINJO Junei
Natural Medicines, Dec. 2003, 57(6):242 - 245, Refereed - Hepatoprotective Constituents in Plants 14. Effects of Soyasapogenol B, Sophoradiol, and Their Glucuronides on the Cytotoxicity of tert-Butyl Hydroperoxide to HepG2 Cells
KINJO Junei; TSUCHIHASHI Ryota; OKAWA Masafumi
Biol. Pharm. Bull., Sep. 2003, 26(9):1357 - 1360, Refereed - Hepatopritective Constituents in Plants 14. Effects of Soyasapogenol B, Sophoradiol, and Thei Glucuronodes on the Cytotoxicity of tert- Butyl Hydroperoxide to HepG2 Cells. J.Kinho, T. Hirakawa, R. Tsuchihashi, T. Nagao. M. Okawa, T.Nohara, H. Okabe,
Bio. Pharm. Bull., 2003, 26(9):1357 - 1360 - Five triterpene glycosides from Oxytropis myriophylla
M Okawa; R Yamaguchi; H Delger; R Tsuchihashi; T Nohara; J Kinjo; S Isoda; Y Ida
CHEMICAL & PHARMACEUTICAL BULLETIN, Aug. 2002, 50(8):1097 - 1099, Refereed - Five Triterpene Glycosides from Oxytropis myriophylla M. Okawa, R. Yamaguchi, H. Delger, R. Tsuchihashi, T. Nohara, J. Kinjo, S. Isoda, Y. Ida,
Chem. Pharm. Bull., 2002, 50(8):1097 - 1099
- 食用豆および大豆加工食品中の活性成分
KINJO Junei; TSUCHIHASHI Ryota, Joint work, 226-238
薬用食品の開発-薬用・有用植物の機能性食品素材への応用-、シーエムシー出版, Jan. 2007
- 腸内細菌による代謝研究(16)ヒト腸内細菌によるクロシンの代謝研究
日本生薬学会第66回年会(東京都), Sep. 2019 - 腸内細菌による代謝研究 (15) ヒト腸内細菌による淡竹葉フラボノイドの代謝研究
日本薬学会第139年会 (千葉市), Mar. 2019 - 大豆の生長段階における成分変化に関する研究―多変量解析法(主成分分析)をもちいて
日本生薬学会第65回年会(広島市), Sep. 2018 - ヒト腸内細菌株による代謝研究(14) -ヒト腸内細菌に よるクワの葉フラボノイドの代謝研究
日本薬学会第138年会 (金沢市), Mar. 2018 - ヒト腸内細菌株による代謝研究(13) ―Kaempferol配糖体の代謝研究―
日本生薬学会第64回年会(船橋市), Sep. 2017 - 葛花の新規イソフラボン配糖体に関する研究(2)
Mar. 2017 - 抱合化によるフィトケミカルの代謝活性化について
KINJO Junei; TSUCHIHASHI Ryota
平成22年度生理学研究所研究会 糖鎖機能研究会・・・分子レベルでの解明を目指して, 02 Jul. 2010 - ヒト腸内細菌による代謝活性化研究 -「酒毒を解す」生薬・葛花に含まれるイソフラボンの肝保護作用について -
土橋良太; 金城順英; 野原稔弘; 中島嘉次郎; 山崎 律; 新甫勇次郎
第17回天然薬物の開発と応用シンポジウム, 14 Nov. 2008 - Soy Isoflavone Metabolites from Human Urine
TSUCHIHASHI Ryota; OKAWA Masafumi; KINJO Junei
2006' International Symposium for Pharmaceutical in Beijing, 11 Oct. 2006
■ Industrial Property Rights
