A combination study of benzyloxyphenyl NCX inhibitor and its insensitive Slc8a1 mutation knock-in mouse reveals NCX1-specific physiological functions
Masahiro Kuwahara; Tomo Kita; Takayuki Nemoto; Yasuharu Shinoda; Tomohiro Komatsu; Satomi Kita; Takahiro Iwamoto
Biochemical and Biophysical Research Communications, Sep. 2025

Perineural treatment with anti-TNF-α antibody ameliorates persistent allodynia and edema in novel mouse models with complex regional pain syndrome.
Shiho Shibata; Hideaki Tagashira; Takayuki Nemoto; Satomi Kita; Tomo Kita; Yasuharu Shinoda; Kouzaburo Akiyoshi; Ken Yamaura; Takahiro Iwamoto
Journal of pharmacological sciences, Sep. 2023, 153(1):1 - 11

YM-244769, a highly potent Na+/Ca2+ exchange inhibitor, efficiently protects renal ischemia-reperfusion injury mice
Nemoto T.; Gotoh Y.; Kuwahara M.; Kita T.; Shinoda Y.; Kita S.; Iwamoto T.
JJSMgR, Jun. 2023, 41(2):66 - 72, Refereed

Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes.
Hideaki Tagashira; Md Shenuarin Bhuiyan; Yasuharu Shinoda; Ichiro Kawahata; Tomohiro Numata; Kohji Fukunaga
Journal of pharmacological sciences, Feb. 2023, 151(2):128 - 133

Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin.
Kazuya Matsuo; Yasuharu Shinoda; Nona Abolhassani; Yusaku Nakabeppu; Kohji Fukunaga
Frontiers in psychiatry, 2022, 13:859198 - 859198

Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress.
An Cheng; Yi-Fei Wang; Yasuharu Shinoda; Ichiro Kawahata; Tetsunori Yamamoto; Wen-Bin Jia; Hanae Yamamoto; Tomohiro Mizobata; Yasushi Kawata; Kohji Fukunaga
Acta pharmacologica Sinica, 02 May 2021, 43(3):552 - 562

Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress
Yifei Wang; Yasuharu Shinoda; An Cheng; Ichiro Kawahata; Kohji Fukunaga
Biomedicines, 22 Jan. 2021, 9(2):110 - 110, Refereed

An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3
Naoya Fukui; Hanae Yamamoto; Moe Miyabe; Yuki Aoyama; Kunihiro Hongo; Tomohiro Mizobata; Ichiro Kawahata; Yasushi Yabuki; Yasuharu Shinoda; Kohji Fukunaga; Yasushi Kawata
Journal of Biological Chemistry, Jan. 2021, 296:100663 - 100663

T-type Ca²⁺ channel enhancer SAK3 administration improves the BPSD-like behaviors in App^{NL−G-F/NL−G-F} knock-in mice
Degawa, T.; Kawahata, I.; Izumi, H.; Shinoda, Y.; Fukunaga, K.
Journal of Pharmacological Sciences, 2021, 146(1):1 - 9, Refereed

Ligand Bound Fatty Acid Binding Protein 7 (FABP7) Drives Melanoma Cell Proliferation Via Modulation of Wnt/β-Catenin Signaling
Umaru, B.A.; Kagawa, Y.; Shil, S.K.; Arakawa, N.; Pan, Y.; Miyazaki, H.; Kobayashi, S.; Yang, S.; Cheng, A.; Wang, Y.; Shinoda, Y.; Kiniwa, Y.; Okuyama, R.; Fukunaga, K.; Owada, Y.
Pharmaceutical Research, 2021, 38(3):479 - 490, Refereed

Wildtype σ1 receptor and the receptor agonist improve ALS-associated mutation-induced insolubility and toxicity
Yasuharu Shinoda; Yudai Haga; Koichiro Akagawa; Kohji Fukunaga
Journal of Biological Chemistry, 18 Dec. 2020, 295(51):17573 - 17587, Refereed
Lead

Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA(A)Receptor
Yasushi Yabuki; Jiaqi Liu; Ichiro Kawahata; Hisanao Izumi; Yasuharu Shinoda; Kohei Koga; Shinya Ueno; Norifumi Shioda; Kohji Fukunaga
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Aug. 2020, 21(15):5525 - 5525, Refereed

Analysis of binding affinity and docking of novel fatty acid-binding protein (FABP) ligands
Yasuharu Shinoda; Yifei Wang; Tetsunori Yamamoto; Hiroyuki Miyachi; Kohji Fukunaga
JOURNAL OF PHARMACOLOGICAL SCIENCES, Aug. 2020, 143(4):264 - 271, Refereed
Lead

SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App(NL-G-F/NL-G-F) Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling
Hisanao Izumi; Ichiro Kawahata; Yasuharu Shinoda; Fred J. Helmstetter; Kohji Fukunaga
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Jun. 2020, 21(11):3833 - 3833, Refereed

Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice
Hidaka Haga; Ryo Yamada; Hisanao Izumi; Yasuharu Shinoda; Ichiro Kawahata; Hiroyuki Miyachi; Kohji Fukunaga
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, Apr. 2020, 191:172891 - 172891, Refereed

Crucial Role of Dopamine D2 Receptor Signaling in Nicotine-Induced Conditioned Place Preference
Gofarana Wilar; Yasuharu Shinoda; Toshikuni Sasaoka; Kohji Fukunaga
MOLECULAR NEUROBIOLOGY, Dec. 2019, 56(12):7911 - 7928, Refereed

Combined citicoline and docosahexaenoic acid treatment improves cognitive dysfunction following transient brain ischemia
Efi Nakazaki; Yasushi Yabuki; Hisanao Izumi; Yasuharu Shinoda; Fumiko Watanabe; Yukihiro Hishida; Ayako Kamimura; Kohji Fukunaga
JOURNAL OF PHARMACOLOGICAL SCIENCES, Apr. 2019, 139(4):319 - 324, Refereed

Development of FABP3 ligands that inhibit arachidonic acid-induced alpha-synuclein oligomerization
An Cheng; Yasuharu Shinoda; Tetsunori Yamamoto; Hiroyuki Miyachi; Kohji Fukunaga
BRAIN RESEARCH, Mar. 2019, 1707:190 - 197, Refereed

KY-226 Protects Blood-brain Barrier Function Through the Akt/FoxO1 Signaling Pathway in Brain Ischemia
Meiling Sun; Yasuharu Shinoda; Kohji Fukunaga
NEUROSCIENCE, Feb. 2019, 399:89 - 102, Refereed

Neuroprotective effects of protein tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice
Meiling Sun; Hisanao Izumi; Yasuharu Shinoda; Kohji Fukunaga
BRAIN RESEARCH, Sep. 2018, 1694:1 - 12, Refereed

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in &ITApp&IT Knock-in Mice
Hisanao Izumi; Yasuharu Shinoda; Takashi Saito; Takaomi C. Saido; Keita Sato; Yasushi Yabuki; Yotaro Matsumoto; Yoshitomi Kanemitsu; Yoshihisa Tomioka; Nona Abolhassani; Yusaku Nakabeppu; Kohji Fukunaga
NEUROSCIENCE, May 2018, 377:87 - 97, Refereed

Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect
Satoru Tamura; Maiko Okada; Shigeaki Kato; Yasuharu Shinoda; Norifumi Shioda; Kohji Fukunaga; Kumiko Ui-Tei; Minoru Ueda
SCIENTIFIC REPORTS, Feb. 2018, 8(1), Refereed

Acute Treatment with T-Type Calcium Channel Enhancer SAK3 Reduces Cognitive Impairments Caused by Methimazole-Induced Hypothyroidism Via Activation of Cholinergic Signaling
Noreen Husain; Yasushi Yabuki; Yasuharu Shinoda; Kohji Fukunaga
PHARMACOLOGY, 2018, 101(5-6):309 - 321, Refereed

Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain
Gofarana Wilar; Kusnandar Anggadiredja; Yasuharu Shinoda; Kohji Fukunaga
PHARMACOLOGY, 2018, 102(3-4):223 - 232, Refereed

trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway
Yusuke Hirata; Miki Takahashi; Yuki Kudoh; Kuniyuki Kano; Hiroki Kawana; Kumiko Makide; Yasuharu Shinoda; Yasushi Yabuki; Kohji Fukunaga; Junken Aoki; Takuya Noguchi; Atsushi Matsuzawa
JOURNAL OF BIOLOGICAL CHEMISTRY, May 2017, 292(20):8174 - 8185, Refereed

Combined Memantine and Donepezil Treatment Improves Behavioral and Psychological Symptoms of Dementia-Like Behaviors in Olfactory Bulbectomized Mice
Yasushi Yabuki; Kazuya Matsuo; Koga Hirano; Yasuharu Shinoda; Shigeki Moriguchi; Kohji Fukunaga
PHARMACOLOGY, 2017, 99(3-4):160 - 171, Refereed

Corticosteroids Mediate Heart Failure-Induced Depression through Reduced sigma 1-Receptor Expression
Yasuharu Shinoda; Hideaki Tagashira; Md. Shenuarin Bhuiyan; Hideyuki Hasegawa; Hiroshi Kanai; Chen Zhang; Feng Han; Kohji Fukunaga
PLOS ONE, Oct. 2016, 11(10):e0163992 - e0163992, Refereed
Lead

Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain
Rie Kusano; Kousuke Fujita; Yasuharu Shinoda; Yuko Nagaura; Hiroshi Kiyonari; Takaya Abe; Toshio Watanabe; Yasuhisa Matsui; Masahiro Fukaya; Hiroyuki Sakagami; Tatsuya Sato; Jun-ichi Funahashi; Motoko Ohnishi; Shinri Tamura; Takayasu Kobayashi
FEBS LETTERS, Oct. 2016, 590(20):3606 - 3615, Refereed

Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction
Yasuharu Shinoda; Hideaki Tagashira; Md. Shenuarin Bhuiyan; Hideyuki Hasegawa; Hiroshi Kanai; Kohji Fukunaga
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2016, 131(3):172 - 183, Refereed
Lead

Alzheimer disease therapeutics candidate, SAK3 improves the cognitive functions through inhibition of amyloid beta accumulation in APP23 mice.
Hisanao Izumi; Yasushi Yabuki; Yasuharu Shinoda; Kohji Fukunaga
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Jun. 2016, 19:253 - 254, Refereed

Memory Improvement by Yokukansankachimpihange and Atractylenolide III in the Olfactory Bulbectomized Mice
Hisanao Izumi; Yuzuru Sasaki; Yasushi Yabuki; Yasuharu Shinoda; Nina Fujita; Satoshi Yomoda; Kohji Fukunaga
Advances in Alzheimer's Disease, 2016, 05(02):35 - 45, Refereed

Dehydroepiandrosterone administration improves memory deficits following transient brain ischemia through sigma-1 receptor stimulation
Yasushi Yabuki; Yasuharu Shinoda; Hisanao Izumi; Tatuya Ikuno; Norifumi Shioda; Kohji Fukunaga
BRAIN RESEARCH, Oct. 2015, 1622:102 - 113, Refereed

Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis
Hideaki Tagashira; Yasuharu Shinoda; Norifumi Shioda; Kohji Fukunaga
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Dec. 2014, 1840(12):3320 - 3334, Refereed

Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites
Yasuharu Shinoda; Kohsuke Fujita; Satoko Saito; Hiroyuki Matsui; Yusuke Kanto; Yuko Nagaura; Kohji Fukunaga; Shinri Tamura; Takayasu Kobayashi
FEBS LETTERS, Sep. 2012, 586(19):3024 - 3029, Refereed
Lead

Pathophysiological Roles and Therapeutic Potential in Neurodegenerative Diseases
Shinoda Y.; Nemoto T.; Iwamoto T.
Med Bullet Fukuoka Univ., May 2023, 50(1):43 - 48, Refereed

Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels
Kohji Fukunaga; Hisanao Izumi; Yasushi Yabuki; Yasuharu Shinoda; Norifumi Shioda; Feng Han
JOURNAL OF PHARMACOLOGICAL SCIENCES, Feb. 2019, 139(2):51 - 58, Refereed

Sigma-1受容体の生理機能と筋萎縮性側索硬化症との関連
Fukunaga, K.; Shinoda, Y.
Seikagaku, 2017, 89(1):106 - 110, Refereed
Last

The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis
Kohji Fukunaga; Yasuharu Shinoda; Hideaki Tagashira
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jan. 2015, 127(1):36 - 41, Refereed

北米神経科学学会

Japanese Association of Cardiovascular Pharmacology

JAPANESE SOCIETY FOR CHEMICAL BIOLOGY

THE JAPANESE SOCIETY FOR NEUROCHEMISTRY

THE JAPANESE BIOCHEMICAL SOCIETY

THE JAPANESE PHARMACOLOGICAL SOCIETY

THE PHARMACEUTICAL SOCIETY OF JAPAN

腸管平滑筋/カハール介在細胞NCX1の多面的腸管運動制御機構の解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2025 - 31 Mar. 2028

ミクログリアサブセット制御異常に基づく複合性局所疼痛症候群発症機序の解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2024 - 31 Mar. 2027

肺動脈性肺高血圧発症におけるNCX1/NCX2の相反する制御機序の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2023 - 31 Mar. 2026

マクロファージNCX1輸送制御に基づく血管新生機序の解明
日本学術振興会, 科学研究費助成事業, 若手研究
福岡大学
01 Apr. 2023 - 31 Mar. 2026

遠位尿細管特異的遺伝子改変マウスを駆使した急性腎障害機序の解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2022 - 31 Mar. 2025

シグマ１受容体変異を伴う筋萎縮性側索硬化症の病態解明と創薬
日本学術振興会, 科学研究費助成事業, 若手研究
東北大学
01 Apr. 2020 - 31 Mar. 2023

自閉症スペクトラム症のミトコンドリア障害と治療薬開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Tohoku University
01 Apr. 2019 - 31 Mar. 2022

心不全を誘導する筋小胞体Ｃａ制御異常のメカニズムとシグマー１受容体の役割の検討
日本学術振興会, 科学研究費助成事業, 特別研究員奨励費
東北大学
25 Apr. 2014 - 31 Mar. 2017