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Last Updated :2024/12/21
School of Medicine
Lecturer/Senior Assistant Professor
Profile1. Microscopic morphology of human head hair and its correlation to successful MTDNA amplification and detection of heteroplasmy. 2. The improvement of a method for analyzing multiple drugs of abuse. 3. A new solid phase microextraction method using vaporization equilibrium. 4. Fast GC-CI-MS/MS method development to create a comprehensive drug database for rapid and sensitive forensic toxicological analysis.
Career
■ Career
- 01 Apr. 2011
Assistant Professor - Fukuoka University, Faculty of Medicine, Department of Forensic Medicine - 01 Jun. 2003 - 28 Feb. 2011
Senior Criminalist - Los Angeles Department of Medical Examiner-Coroner - 01 Nov. 2001 - 30 Apr. 2003
Research Assistant - California State University, Los Angeles, Department of Criminalistics - 01 Jul. 1998 - 30 Jun. 2000
Assistant Language Teacher (English) with the Japan Exchange and Teaching (JET) Program
Research activity information
■ Award
- 06 Jul. 2012
The Society of Forensic Toxicologists, Inc., Leo Dal Cortivo/Young Forensic Toxicologist Award for Best Platform Presentation of SOFT 2012 by a Young Forensic Toxicologist
A Toxicological Approach to Confirm the Inhalation of Pyrolysis Products in Burned Cadavers Using Headspace Solid-phase Microextraction and Cryogenic Gas Chromatography-Mass Spectrometry - 01 May 1998
Magna Cum Laude Graduate - 01 Aug. 1993
Erlanger Textile Merit Scholar
- A validated method for the separation of ethyl glucoside isomers by gas chromatography-tandem mass spectrometry and quantitation in human whole blood and urine
Brian Waters
Journal of Chromatography B, 2022 - Giant intracranial arteriovenous malformation as a possibility of epileptic seizures in a case of drowning
Brian Waters
Legal Medicine, 2022 - Diagnostic meaning of urinary ethyl glucoside concentrations in relationship to alcoholic beverage consumption
Brian Waters
Legal Medicine, 2022 - A comparative study of pleural effusion in water area, water temperature and postmortem interval in forensic autopsy cases of drowning.
Akiko Ishigami; Masayuki Kashiwagi; Yuko Ishida; Kenji Hara; Mizuho Nosaka; Aya Matsusue; Hiroki Yamamoto; Brian Waters; Toshikazu Kondo; Shin-Ichi Kubo
Scientific reports, 02 Nov. 2021, 11(1):21528 - 21528, Refereed - Effects of putrefaction on the quantitative analyses of diphenhydramine in blood and tissues: model experiments by the routine matrix-matched calibration method and standard addition method with different internal standards
Keiko Kudo; Kanju Saka; Brian Waters; Kenji Hara; Aya Matsusue; Masayuki Kashiwagi; Shin-ichi Kubo
FORENSIC TOXICOLOGY, Jul. 2021, 39(2):437 - 450, Refereed - A large interhemispheric glioependymal cyst associated with partial defect of the corpus callosum in an elderly man
Mio Takayama; Masayuki Kashiwagi; Kenji Hara; Aya Matsusue; Brian Waters; Shin-ichi Kubo
Neuropathology, 01 Oct. 2020, 40(5):496 - 500 - 法医剖検例における脳脊髄液中カテコラミン濃度およびMAOA遺伝子プロモーター領域のVNTR多型の関連
松末 綾; 石川 隆紀; 池田 知哉; 谷 直人; Brian Waters; 原 健二; 柏木 正之; 高山 みお; 久保 真一
日本法医学雑誌, Aug. 2020, 74(1):56 - 56 - VNTR polymorphism in the monoamine oxidase A promoter region and cerebrospinal fluid catecholamine concentrations in forensic autopsy cases
Brian Waters
Neuroscience Letters, Feb. 2019, 701:71 - 76, Refereed - Fatal accidental asphyxia in the reverse jack-knife position on a chair with wheels
Brian Waters
Legal Medicine, 2019 - Organ distribution of endogenous p-cresol in hemodialysis patients
Brian Waters
Journal of Medical Investigation, 2019, 66:81 - 85, Refereed - 体液中覚醒剤濃度とCYP2D6遺伝子多型の関連
松末 綾; 石川 隆紀; 池田 知哉; 道上 知美; Waters Brian; 原 健二; 高山 みお; 池松 夏紀; 柏木 正之; 久保 真一
日本法医学雑誌, Dec. 2018, 72(2):327 - 327 - Association between cytochrome P450 2D6 polymorphisms and body fluid methamphetamine concentrations in Japanese forensic autopsy cases
Brian Waters
Forensic Science International, Aug. 2018, 289:33 - 39, Refereed - DRD2/ANKK1 gene polymorphisms in forensic autopsies of methamphetamine intoxication fatalities
Brian Waters
Legal Medicine, Jul. 2018, 33:6 - 9, Refereed - Effects of PCR inhibitors on mRNA expression for human blood identification
Shusaku Matsumura; Aya Matsusue; Brian Waters; Masayuki Kashiwagi; Kenji Hara; Shin-ichi Kubo
Legal Medicine, 01 May 2018, 32:113 - 119 - Diagnostic meaning of blood p-cresol concentration in forensic autopsy cases.
Ikematsu N; Kashiwagi M; Hara K; Waters B; Matsusue A; Takayama M; Kubo SI
Leg Med, 2018, 34:27 - 35, Refereed - An unusual case of suicide by methanol ingestion.
Waters B; Hara K; Ikematsu N; Takayama M; Matsusue A; Kashiwagi M; Kubo SI
Forensic Sci Int., 2018, 289:e9 - e14, Refereed - Tissue Distribution of Suvorexant in Three Forensic Autopsy Cases
Brian Waters
Journal of Analytical Toxicology, 2018, 42(4):276 - 283, Refereed - A modified direct-heating headspace solid-phase microextraction method for drug screening with urine samples
Brian Waters
Forensic Toxicology, 2018, 36(1):225 - 228, Refereed - Subarachnoid hemorrhage in a Japanese cocaine abuser: Cocaine-related sudden death.
Takayama M; Waters B; Fujii H; Hara K; Kashiwagi M; Matsusue A; Ikematsu N; Kubo S
Leg Med., 2018, 32:43 - 47, Refereed - Quantitation of tetrodotoxin in postmortem specimens using SPE and HILIC LC-MS/MS: Tissue distribution of a forensic autopsy case.
Waters B; Hara K; Ikematsu N; Takayama M; Matsusue A; Kashiwagi M; Kubo S
Jpn J Forensic Sci Tech., 2018, 23(2):125 - 131, Refereed - Giant intracranial arteriovenous malformation as the focus of epileptic seizures
Brian Waters
Neuropathology, 2018, 38(2):185 - 191 - Basal subarachnoid hemorrhage by rupture of arteriovenous malformation at the cerebellopontine angle
Mio Takayama; Masayuki Kashiwagi; Kenji Hara; Aya Matsusue; Brian Waters; Natsuki Ikematsu; Shin-ichi Kubo
NEUROPATHOLOGY, Oct. 2017, 37(5):441 - 445 - An autopsy case of serotonin syndrome induced by illegal antipsychotics
Mio Takayama; Brian Waters; Kenji Hara; Masayuki Kashiwagi; Aya Matsusue; Hiroshi Fujii; Natsuki Ikematsu; Shin-ichi Kubo
ROMANIAN JOURNAL OF LEGAL MEDICINE, Sep. 2017, 25(3):260 - 265 - A report of novel psychoactive substances in forensic autopsy cases and a review of fatal cases in the literature
Shin-ichi Kubo; Brian Waters; Kenji Hara; Tatsushige Fukunaga; Kazuya Ikematsu
LEGAL MEDICINE, May 2017, 26:79 - 85, Refereed - Volatile Hydrocarbon Analysis in Blood by Headspace Solid-Phase Microextraction: The Interpretation of VHC Patterns in Fire-Related Incidents
Brian Waters; Kenji Hara; Natsuki Ikematsu; Mio Takayama; Masayuki Kashiwagi; Aya Matsusue; Shin-ichi Kubo
JOURNAL OF ANALYTICAL TOXICOLOGY, May 2017, 41(4):300 - 306 - 正座が原因と考えられた肺血栓塞栓症の１剖検例．
MATSUSUE Aya; KUBO Shin-Ichi; KASHIWAGI Masayuki; HARA Kenji; WATERS Brian; TAKAYAMA Mio
法医学の実際と研究, 2017, 60:155 - 160 - 法医剖検例における血中カフェイン濃度の概要．
MATSUSUE Aya; KUBO Shin-Ichi; KASHIWAGI Masayuki; HARA Kenji; WATERS Brian; TAKAYAMA Mio
日本アルコール・薬物医学会雑誌, 2017, 52(6):297 - 305 - Simple regioisomeric differentiation of 2-, 3- and 4-methyl-α-pyrrolidinobutiophenones by gas chromatography–mass spectrometry using bromination.
Hiroshi Fujii; Brian Waters; Kenji Hara; Masayuki Kashiwagi; Aya Matsusue; Shin-ichi Kubo
FORENSIC TOXICOLOGY, Jan. 2017, 35(1):162 - 166 - Association between cerebrospinal fluid dopamine concentrations and catechol-O-methyltransferase gene polymorphisms in forensic autopsy cases of methamphetamine abusers
Aya Matsusue; Takaki Ishikawa; Tomomi Michiue; Brian Waters; Kenji Hara; Masayuki Kashiwagi; Mio Takayama; Natsuki Ikematsu; Shin-ichi Kubo
FORENSIC SCIENCE INTERNATIONAL, Jan. 2017, 270:159 - 164 - Quantification of immunohistochemical findings of neurofibrillary tangles and senile plaques for a diagnosis of dementia in forensic autopsy cases
Mio Takayama; Masayuki Kashiwagi; Aya Matsusue; Brian Waters; Kenji Hara; Natsuki Ikematsu; Shin-ichi Kubo
LEGAL MEDICINE, Sep. 2016, 22:82 - 89 - Application of mRNA Expression Analysis to Human Blood Identification in Degenerated Samples that were False-negative by Immunochromatography
Shusaku Matsumura; Aya Matsusue; Brian Waters; Masayuki Kashiwagi; Kenji Hara; Shin-ichi Kubo
JOURNAL OF FORENSIC SCIENCES, Jul. 2016, 61(4):903 - 912 - Development of a preparation method to produce a single sample that can be applied to both LC-MS/MS and GC-MS for the screening of postmortem specimens
Kenji Hara; Brian Waters; Natsuki Ikematsu; Tomoko Tokuyasu; Hiroshi Fujii; Mio Takayama; Aya Matsusue; Masayuki Kashiwagi; Shin-ichi Kubo
LEGAL MEDICINE, Jul. 2016, 21:85 - 92 - GC-PCI-MS/MS and LC-ESI-MS/MS databases for the detection of 104 psychotropic compounds (synthetic cannabinoids, synthetic cathinones, phenethylamine derivatives)
Brian Waters; Natsuki Ikematsu; Kenji Hara; Hiroshi Fujii; Tomoko Tokuyasu; Mio Takayama; Aya Matsusue; Masayuki Kashiwagi; Shin-ichi Kubo
LEGAL MEDICINE, May 2016, 20:1 - 7 - The global distribution of the p.R1193Q polymorphism in the SCN5A gene
Aya Matsusue; Isao Yuasa; Kazuo Umetsu; Nori Nakayashiki; Koji Dewa; Hiroaki Nishimukai; Masayuki Kashiwagi; Kenji Hara; Brian Waters; Mio Takayama; Natsuki Ikematsu; Shin-ichi Kubo
LEGAL MEDICINE, Mar. 2016, 19(19):72 - 76 - An unexpected death due to massive ascites and a giant mucinous ovarian cystadenoma
Brian Waters
Legal Medicine, 2016 - Quantification of neuropathological findings by image data for the diagnosis of dementia in forensic autopsy cases.
Takayama Mio; Kashiwagi Masayuki; Matsusue Aya; Waters Brian; Hara Kenji; Ikematsu Natsuki; Kubo Shin-ichi
Journal of Medical Investigation, 2016, 63(1-2):114 - 118 - 薬毒物検査によるケトン体分析システムの提案–法医剖検例における病態補助診断として
法医学の実際と研究, 2016, 59:21 - 27 - Quantification of neuropathological findings by image data for the diagnosis of dementia in forensic autopsy cases.
TAKAYAMA Mio; KASHIWAGI Masayuki; MATSUSUE Aya; WATERS Brian; HARA Kenji; IKEMATSU Natsuki; KUBO Shin-Ichi
J Med Invest, 2016, 63(1):114 - 118 - カフェイン飲料・製剤の過剰摂取によるカフェイン中毒事故の1剖検例
TAKAYAMA Mio; WATERS Brian; HARA Kenji; KASHIWAGI Masayuki; MATSUSUE Aya; IKEMATSU Natsuki; KUBO Shin-Ichi
日本アルコール・薬物医学会雑誌, 2016, 51(3):228 - 233 - Direct-heating headspace solid-phase microextraction for the screening of illicit drugs
Hiroshi Fujii; Brian Waters; Kenji Hara; Masayuki Kashiwagi; Aya Matsusue; Mio Takayama; Shin-ichi Kubo
Forensic Toxicology, 01 Jan. 2015, 33(1):61 - 68 - 強皮症の1剖検例：心肥大の発生機序の検討
TAKAYAMA Mio; KASHIWAGI Masayuki; HARA Kenji; MATSUSUE Aya; WATERS Brian; IKEMATSU Natsuki; KUBO Shin-Ichi
法医学の実際と研究, 2015 - 食道・胃破裂を認めた解熱鎮痛剤中毒死の１剖検例
TAKAYAMA Mio; WATERS Brian; HARA Kenji; MATSUSUE Aya; KASHIWAGI Masayuki; KUBO Shin-Ichi
法医学の実際と研究, 2014 - Immunohistochemical investigation of the coma blister and its pathogenesis
Brian Waters
Journal of Medical Investigation, 2013 - Combination of a short middle-bore capillary column with a thicker stationary phase and a short narrow-bore separation column with a thinner stationary phase for the rapid screening of non-volatile drugs by gas chromatography-mass spectrometry
Brian Waters
Forensic Toxicology, 2013 - Methamphetamine and amphetamine concentrations in survivors of body-packer syndrome in Japan
Brian Waters
Forensic Science International, 2013 - Application of high-throughput chiral analysis of amphetamines by GC-MS to whole blood specimens
Brian Waters
Forensic Toxicology, 2013 - Diagnostic implications of urinary liver-type fatty acid-binding protein and 8-hydroxy-2 '-deoxyguanosine in forensic autopsy cases
Brian Waters
Legal Medicine, 2013 - アンモニアガス曝露による事故死例：皮膚損傷の免疫組織化学的検討
TAKAYAMA Mio; KASHIWAGI Masayuki; HARA Kenji; MATSUSUE Aya; WATERS Brian; TAKAMOTO Mutsuo; KUBO Shin-Ichi
法医学の実際と研究, 2013 - Renal immunohistochemical investigation for the differentiation of the cause of multiple trauma fatalities
Brian Waters
Legal Medicine, 2012 - An autopsy case of sudden unexpected nocturnal death syndrome with R1193Q polymorphism in the SCN5A gene
Brian Waters
Legal Medicine, 2012
- 覚醒剤摂取症例におけるCOMT遺伝子多型と脳脊髄液中ドパミン濃度の関連
松末 綾; 石川 隆紀; 道上 知美; Waters Brian; 原 健二; 高山 みお; 池松 夏紀; 柏木 正之; 久保 真一
日本法医学雑誌, Dec. 2017, 71(2):165 - 165 - 覚醒剤中毒死症例におけるDRD2/ANKK1遺伝子多型解析
松末 綾; 石川 隆紀; 道上 知美; Waters Brian; 原 健二; 高山 みお; 池松 夏紀; 柏木 正之; 久保 真一
日本法医学雑誌, May 2017, 71(1):87 - 87
- An autopsy case of dissection of the aorta found in a relatively young male without arteriosclerosis.
The 12th Indo Pacific Association of Law, Medicine and Science Congress, 2016 - Preliminary testing of drug analysis in urine by a direct-heating headspace solid-phase microextraction method.
The 12th Indo Pacific Association of Law, Medicine and Science Congress, 2016 - The meaning of blood ketone bodies in forensic autopsy cases.
Der 94. Jahrestagung der Deutschen Gesellschaft fur Rechtmedizin, 2016 - An autopsy case of a giant intracranial arteriovenous malformation.
Der 94. Jahrestagung der Deutschen Gesellschaft fur Rechtmedizin, 2016 - 巨大脳動静脈奇形を認めた頭部外傷の1剖検例．
第100次日本法医学会学術全国集会, 2016 - mRNAを用いた血液証明に対するPCR阻害物質の影響．
第100次日本法医学会学術全国集会, 2016 - A method for the quantitation of tetrodotoxin in postmortem specimens using SPE and HILIC LC-MS/MS.
第100次日本法医学会学術全国集会, 2016 - 法医剖検例における血中ケトン体の意義．
第100次日本法医学会学術全国集会, 2016 - Quantification of immunohistochemical findings of neurofibrillary tangles and senile plaques by image data for a diagnosis of dementia in forensic autopsy cases.
第100次日本法医学会学術全国集会, 2016 - 中国人特異的アレルの検索
日本DNA多型学会第25回学術集会, 2016 - Evaluation of a preparation method that can be applied to both LC-MS/MS and GC-MS for the screening of postmortem specimens.
日本医用マススペクトル学会, 2016 - 覚醒剤摂取症例におけるCOMT遺伝子多型と脳脊髄液中ドパミン濃度の関連．
第66回日本法医学会学術九州地方集会, 2016 - 正座が原因と考えられた肺動脈血栓塞栓症の１剖検例．
第66回日本法医学会学術九州地方集会, 2016 - 突然死に対する新生児マススクリーニング対象疾患遺伝子の網羅的検索．
第66回日本法医学会学術九州地方集会, 2016
- Society of Forensic Toxicologists
- 日本法医学会
- 日本法医中毒学会
- The International Association of Forensic Toxicologists
- 覚醒剤の毒性発現の個人差に影響する遺伝的要因の解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2022 - 31 Mar. 2025 - 覚醒剤の毒性発現に関与する遺伝子の特定と死因究明への応用
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2019 - 31 Mar. 2023 - 尿毒素としての腸内細菌産生フェニルアセチルグルタミンの法医剖検診断の意義の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2019 - 31 Mar. 2023 - 新規動脈硬化診断指標：LC―MS／MSイソプロスタン分析法の臨床的意義の確立
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2017 - 31 Mar. 2020 - 数時間前の飲酒の証明に挑戦する：新たな飲酒マーカー・腸管を経由した酒類成分の探索
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory)
Fukuoka University
30 Jun. 2017 - 31 Mar. 2019 - 乳幼児突然死の原因究明にむけて：遺伝的背景の検討と新たな遺伝子診断法の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
21 Oct. 2015 - 31 Mar. 2018 - インスリン大量投与による死亡例の剖検診断：インスリン製剤の検出法の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2016 - 心臓突然死の迅速な遺伝子診断法の開発：致死性不整脈原因遺伝子変異の探索のために
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2016 - 死因究明のための体組織からの高感度・迅速薬物スクリーニング・システムの開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2015 - 高温気化固相マイクロ抽出法の開発：血中薬物ＧＣ－ＭＳ分析の迅速化を目指して
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2014 - 薬毒物関連死の剖検診断の新たな展開に向けて:遺伝学的背景の検討
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Fukuoka University
2009 - 2011
