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Last Updated :2025/05/14

Makoto Takada

Department of Phatmaceutics
Associate professor

Researcher information

■ Degree
  • 博士(薬学), 長崎国際大学
■ Research Keyword
  • 質量分析
  • 液体クロマトグラフィー
  • 分析化学
■ Field Of Study
  • Life sciences, Pharmaceuticals - analytical and physicochemistry, 分析化学

Research activity information

■ Paper
  • Quantitation of Vaporized γ‐Aminobutyric Acid in Cigarette Smoke Extract From e‐Cigarettes by the Combination of HPLC‐Fluorescence Detection and Derivatization With DBD‐F
    Mitsuhiro Wada; Haruna Onodera; Makoto Takada; Suzuna Saruwatari; Junpei Mutoh; Ken Tachibana; Tadashi Hayama; Naoya Kishikawa; Naotaka Kuroda
    Luminescence, 21 Nov. 2024, 39(11)
  • Highly Sensitive Analysis for Ophthalmic Acid by PEG-Based Derivatization Method with HILIC-MS
    Nao NISHIJO; Ryoko TOMITA; Makoto TAKADA; Tadashi HAYAMA
    CHROMATOGRAPHY, 13 Sep. 2024
  • Bactericidal Efficacy of So-Called Sanitizers in Japan.
    Ryosuke Funaki; Saki Nomura; Akira Ushima; Shigeharu Oie; Makoto Takada; Mitsuhiro Wada
    Biological & pharmaceutical bulletin, Sep. 2024, 47(10):1644 - 1647
  • LC-MS/MS analysis of components in smoke from e-cigarettes that use guarana extract as the caffeine source.
    Suzuna Saruwatari; Makoto Takada; Junpei Mutoh; Naoya Kishikawa; Naotaka Kuroda; Mitsuhiro Wada
    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, May 2024, 40(5):959 - 963
  • Extremely Simple and Rapid HPLC Analysis of Tocilizumab in Human Serum with Selective Precipitation Using Alkylamine
    Makoto Takada; Ichika Watanabe; Kazuya Naito; Junpei Mutoh; Yoshihito Ohba; Tsutomu Kabashima; Mitsuhiro Wada
    Chemical and Pharmaceutical Bulletin, 01 Jan. 2023, 71(1):19 - 23, Refereed
    Lead
  • Analysis of vaporized caffeine in smoke from e-cigarettes using liquid chromatography–tandem mass spectrometry and clarification of minor components
    Makoto Takada; Suzuna Saruwatari; Yutaro Yanagita; Junpei Mutoh; Hajime Harada; Naoya Kishikawa; Takashi Kitahara; Naotaka Kuroda; Mitsuhiro Wada
    Forensic Toxicology, 2022, Refereed
    Lead
  • HPLC Fluorescence Method for Eugenols in Basil Products Derivatized with DIBI.
    Makoto Takada; Masashi Sakamoto; Haruna Yamada; Naoya Kishikawa; Junpei Mutoh; Yukihide Shiraishi; Naotaka Kuroda; Mitsuhiro Wada
    Chemical & pharmaceutical bulletin, 2022, 70(1):37 - 42, Refereed
    Lead
  • Simple Simultaneous Assay of Methotrexate and Non-Steroidal Anti-Inflammatory Drugs by HPLC
    Takada M; Ohba Y; Kabashima T; Nakashima K; Wada M
    Chromatography, Sep. 2020, 41:79 - 84, Refereed
    Lead
  • Simultaneous assay for protease activities of hepatitis C virus and human immunodeficiency virus based on fluorescence detection.
    Kabashima T; Tonooka K; Takada M; Kai M; Shibata T
    Scientific reports, Jun. 2019, 9(1):9150 - 9150, Refereed
  • Simple and rapid analysis of tocilizumab using HPLC-fluorescence detection method.
    Takada M; Ohba Y; Kamiya S; Kabashima T; Nakashima K
    Luminescence : the journal of biological and chemical luminescence, May 2019, 34(3):347 - 352, Refereed
    Lead
  • Luminol Chemiluminescence Profile of O/W Emulsions during Thermal Oxidation
    Mitsuhiro Wada; Akiko Yamaguchi; Akihiro Ogawa; Hirotsugu Kido; Shinichi Nakamura; Makoto Takada; Shigeru Kawakami; Naotaka Kuroda; Kenichiro Nakashima
    ANALYTICAL SCIENCES, Feb. 2017, 33(2):249 - 252, Refereed
  • Determination of Asperulosidic Acid and Deacetylasperulosidic Acid in Rat Plasma After Administration of Morinda citrifolia Juice
    Wada Mitsuhiro; Yamasaki Yutaro; Nakamura Shinichi; Takada Makoto; Kawakami Shigeru; Nakashima Kenichiro
    CHROMATOGRAPHY, 2016, 37(3):141 - 145, Refereed
  • Association of decreased mRNA expression of multidrug and toxin extrusion protein 1 in peripheral blood cells with the development of flutamide-induced liver injury
    Kazuhiko Nakano; Hitoshi Ando; Shinsuke Kurokawa; Keiko Hosohata; Kentarou Ushijima; Makoto Takada; Masato Tateishi; Atsushi Yonezawa; Satohiro Masuda; Kazuo Matsubara; Ken-ichi Inui; Tatsuo Morita; Akio Fujimura
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, Jun. 2015, 75(6):1191 - 1197, Refereed
  • The effect of carboxylesterase 1 (CES1) polymorphisms on the pharmacokinetics of oseltamivir in humans
    Yuki Suzaki; Naoto Uemura; Makoto Takada; Tetsuji Ohyama; Akiko Itohda; Takuya Morimoto; Hiromitsu Imai; Hajime Hamasaki; Akihiro Inano; Masakiyo Hosokawa; Masato Tateishi; Kyoichi Ohashi
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, Jan. 2013, 69(1):21 - 30, Refereed
  • Influence of Dosing Time on the Efficacy and Safety of Finasteride in Rats
    Masafumi Kumazaki; Hitoshi Ando; Kentarou Ushijima; Tomohiro Maekawa; Yuya Motosugi; Makoto Takada; Masato Tateishi; Akio Fujimura
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Aug. 2011, 338(2):718 - 723, Refereed
  • Chronopharmacology of Angiotensin II-receptor Blockers in Stroke-Prone Spontaneously Hypertensive Rats
    Yuwang Liu; Kentarou Ushijima; Masami Ohmori; Makoto Takada; Masato Tateishi; Hitoshi Ando; Akio Fujimura
    JOURNAL OF PHARMACOLOGICAL SCIENCES, Feb. 2011, 115(2):196 - 204, Refereed
  • Simple and rapid method for the determination of ethylenebisdithiocarbamate fungicides in fruits and vegetables using liquid chromatography with tandem mass spectrometry
    Tadashi Hayama; Makoto Takada
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Nov. 2008, 392(5):969 - 976, Refereed
■ Lectures, oral presentations, etc.
  • ASAP-MS法による化粧品中紫外線吸収剤の一斉分析法の開発
    吉原菜々美; 中村沙織; 岩下美悠; 岡元美樹; 高田誠; 高井伸彦; 大庭義史
    第36回日本薬学会九州支部大会, Nov. 2019
  • HPLC-Fluorescence Detection Method for Derivatized Homocysteine and Its Related Compounds with DBD-F in Human Biological Samples
    Mitsuhiro Wada; Makoto Takada; Junpei Mutoh; Tsutomu Kabashima; Kenichiro Nakashima
    The 7th Annual Conference of AnalytiX-2019, Nov. 2019
  • Simultaneous HPLC determination of Methotrexate and NSAIDs in Serum
    Kenichiro Nakashima; Makoto Takada; Tsutomu Kabashima; Mitsuhiro Wada
    The 7th Annual Conference of AnalytiX-2019, Nov. 2019
  • 迅速かつ簡便なメトトレキサートとNSAIDsの同時定量法の開発
    Makoto Takada
    Mar. 2018
  • 迅速かつ簡便な生体試料中トシリズマブHPLC蛍光検出法の開発
    Makoto Takada
    日本薬学会第139年会, Mar. 2018
  • Development and application of high-performance liquid chromatography with fluorescent detection of tocilizumab
    Makoto Takada; Seitaro Kamiya; Yoshihito Ohba; Kenichiro Nakashima
    XVII International Symposium on Luminescence Spectrometry 2016, 2016
  • 日焼け止め中紫外線吸収剤のASAP-MS分析
    中村沙織; 岩下美悠; 岡元美樹; 高田誠; 高井伸彦; 大庭義史
    第79回分析化学討論会
■ Affiliated academic society
  • JAPAN SOCIETY OF CLINICAL CHEMISTRY
  • THE PHARMACEUTICAL SOCIETY OF JAPAN
  • THE JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY
■ Research Themes
  • FRETに基づくトシリズマブの新規HPLC法の開発と薬物相互作用解明への応用
    日本学術振興会, 科学研究費助成事業, 若手研究
    山陽小野田市立山口東京理科大学
    01 Apr. 2020 - 31 Mar. 2024