Spatial transcriptomics of the epipharynx in long COVID identifies SARS-CoV-2 signalling pathways and the therapeutic potential of epipharyngeal abrasive therapy.
Kensuke Nishi; Shohei Yoshimoto; Takayuki Tanaka; Shoichi Kimura; Toshiyuki Tsunoda; Akira Watanabe; Kaori Teranaka; Yo Oguma; Hanako Ogawa; Takumi Kumai; Takafumi Yamano
Scientific reports, 12 Mar. 2025, 15(1):8618 - 8618

RAD52-mediated repair of DNA double-stranded breaks at inactive centromeres leads to subsequent apoptotic cell death.
Gen Maruta; Hisanori Maeoka; Toshiyuki Tsunoda; Kozaburo Akiyoshi; Satoshi Takagi; Senji Shirasawa; Shuhei Ishikura
Nucleic acids research, 27 Nov. 2024, 52(21):12961 - 12975

Inhibitory Effect of Pyra-Metho-Carnil on the Differentiation and Maturation of Macrophages in Normal and Cancer Microenvironments.
Takanori Kitaguchi; Taichi Matsumoto; Kazumasa Yoshida; Yuriko Hamaguchi; Gen Maruta; Hisanori Maeoka; Shuhei Ishikura; Michitaka Nakano; Yusuke Ishida; Fumihito Hirai; Mikiko Aoki; Shohta Kodama; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2024, 44(8):3557 - 3565

MMP-2 Regulation of Emmprin on Tumour Cells and CD73 on Fibroblasts During Tumour-Stromal Interaction.
Mikiko Aoki; Toshiyuki Tsunoda; Kaori Koga; Kazuki Nabeshima; Makoto Hamasaki
Anticancer research, Aug. 2023, 43(8):3735 - 3745

Inhibitory Effect of Pyra-Metho-Carnil on Cancer Spheroid Growth Through Decrease in Glycolysis-associated Molecules.
Kazumasa Yoshida; Kensuke Nishi; Shuhei Ishikura; Taichi Matsumoto; Kazuhiko Nakabayashi; Ryo Yazaki; Takashi Ohshima; Masahiko Suenaga; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2023, 43(8):3717 - 3726

Death domain-associated protein DAXX regulates noncoding RNA transcription at the centromere through the transcription regulator ZFAT.
Shuhei Ishikura; Kazumasa Yoshida; Toshiyuki Tsunoda; Senji Shirasawa
The Journal of biological chemistry, Nov. 2022, 298(11):102528 - 102528

Cryptotanshinone suppresses tumorigenesis by inhibiting lipogenesis and promoting reactive oxygen species production in KRAS‑activated pancreatic cancer cells.
Tokio Terado; Chul Jang Kim; Akiyo Ushio; Kahori Minami; Yukihiro Tambe; Susumu Kageyama; Akihiro Kawauchi; Toshiyuki Tsunoda; Senji Shirasawa; Hiroyuki Tanaka; Hirokazu Inoue
International journal of oncology, Sep. 2022, 61(3)

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis.
Kensuke Nishi; Shohei Yoshimoto; Soichiro Nishi; Tatsuro Nishi; Ryushiro Nishi; Takayuki Tanaka; Toshiyuki Tsunoda; Kazuaki Imai; Hiroaki Tanaka; Osamu Hotta; Ayaki Tanaka; Kenji Hiromatsu; Senji Shirasawa; Takashi Nakagawa; Takafumi Yamano
International journal of molecular sciences, 16 Aug. 2022, 23(16):9205 - 9205, Refereed

Chitinase 3-like 1, Carcinoembryonic Antigen-related Cell Adhesion Molecule 6, and Ectopic Claudin-2 in the Carcinogenic Processes of Ulcerative Colitis.
Tetsushi Kinugasa; Toshiyuki Tsunoda; Emiko Mizoguchi; Toshiyuki Okada; Tomoya Sudo; Akihiko Kawahara; Jun Akiba; Yoshito Akagi
Anticancer research, Aug. 2022, 42(8):4119 - 4127

Standardized Methods Using EUS-guided Fine-needle Biopsy and a Minimal Medium Creates Three Pancreatic Cancer Organoids.
Yusuke Ishida; Toshiyuki Tsunoda; Yoshihiro Hamada; Naoaki Tsuchiya; Takehiko Koga; Takanori Kitaguchi; Keisuke Matsumoto; Shinji Matsumoto; Takahide Sasaki; Ryo Nakashima; Fuminori Ishii; Masatoshi Kajiwara; Senji Shirasawa; Suguru Hasegawa; Fumihito Hirai
Anticancer research, Aug. 2022, 42(8):4103 - 4109

Cancer Spheroid Proliferation Is Suppressed by a Novel Low-toxicity Compound, Pyra-Metho-Carnil, in a Context-independent Manner.
Kazumasa Yoshida; Kensuke Nishi; Shuhei Ishikura; Kazuhiko Nakabayashi; Ryo Yazaki; Takashi Ohshima; Masahiko Suenaga; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2022, 42(8):3993 - 4001

Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment.
Kazuaki Imai; Takafumi Yamano; Soichiro Nishi; Ryushiro Nishi; Tatsuro Nishi; Hiroaki Tanaka; Toshiyuki Tsunoda; Shohei Yoshimoto; Ayaki Tanaka; Kenji Hiromatsu; Senji Shirasawa; Takashi Nakagawa; Kensuke Nishi
Viruses, 27 Apr. 2022, 14(5):907 - 907, Refereed

Epipharyngeal Abrasive Therapy Down-regulates the Expression of SARS-CoV-2 Entry Factors ACE2 and TMPRSS2.
Kensuke Nishi; Shohei Yoshimoto; Soichiro Nishi; Toshiyuki Tsunoda; Jun Ohno; Michinobu Yoshimura; Kenji Hiromatsu; Takafumi Yamano
In vivo (Athens, Greece), 2022, 36(1):371 - 374

Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.
Kensuke Nishi; Shohei Yoshimoto; Soichiro Nishi; Tatsuro Nishi; Ryushiro Nishi; Toshiyuki Tsunoda; Hiromitsu Morita; Hiroaki Tanaka; Osamu Hotta; Susumu Yasumasu; Kenji Hiromatsu; Senji Shirasawa; Takashi Nakagawa; Takafumi Yamano
In vivo (Athens, Greece), 2022, 36(5):2357 - 2364

Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1.
Palanivel Kandasamy; Inti Zlobec; Damian T Nydegger; Jonai Pujol-Giménez; Rajesh Bhardwaj; Senji Shirasawa; Toshiyuki Tsunoda; Matthias A Hediger
Molecular oncology, Oct. 2021, 15(10):2782 - 2800, Refereed

CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA.
Shuhei Ishikura; Kazumasa Yoshida; Sayuri Hashimoto; Kazuhiko Nakabayashi; Toshiyuki Tsunoda; Senji Shirasawa
The Journal of biological chemistry, Oct. 2021, 297(4):101213 - 101213, Refereed

Growth Suppression of Cancer Spheroids With Mutated KRAS by Low-toxicity Compounds from Natural Products.
Sayuri Hashimoto; Masayoshi Nagai; Kensuke Nishi; Shuhei Ishikura; Kazuhiko Nakabayashi; Ryo Yazaki; Takashi Ohshima; Masahiko Suenaga; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2021, 41(8):4061 - 4070, Refereed

Effects of Aspergillus fumigatus Conidia on Apoptosis and Proliferation in an In Vitro Model of the Lung Microenvironment.
Hisako Kushima; Toshiyuki Tsunoda; Taichi Matsumoto; Yoshiaki Kinoshita; Koichi Izumikawa; Senji Shirasawa; Masaki Fujita; Hiroshi Ishii
Microorganisms, 02 Jul. 2021, 9(7):1435, Refereed

The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes.
Shuhei Ishikura; Masayoshi Nagai; Toshiyuki Tsunoda; Kensuke Nishi; Yoko Tanaka; Midori Koyanagi; Senji Shirasawa
Journal of cellular biochemistry, Jun. 2021, 122(6):626 - 638, Refereed

ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B-H4K8ac-BRD4 axis.
Shuhei Ishikura; Kazuhiko Nakabayashi; Masayoshi Nagai; Toshiyuki Tsunoda; Senji Shirasawa
Nucleic acids research, 04 Nov. 2020, 48(19):10848 - 10866, Refereed

Mutant KRAS Promotes NKG2D+ T Cell Infiltration and CD155 Dependent Immune Evasion.
Kensuke Nishi; Shuhei Ishikura; Masayo Umebayashi; Takashi Morisaki; Takashi Inozume; Tetsushi Kinugasa; Mikiko Aoki; Satoshi Nimura; Anthony Swain; Yoichiro Yoshida; Suguru Hasegawa; Kazuki Nabeshima; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2020, 40(8):4663 - 4674, Refereed

MK615 Suppresses Hypoxia Tolerance by Up-regulation of E-cadherin in Colorectal Cancer Cells With Mutant KRAS.
Kensuke Nishi; Toshiyuki Tsunoda; Yoshinori Uchida; Takayuki Sueta; Motohiro Sawatsubashi; Takafumi Yamano; Yasuko Hashiguchi; Anthony Swain; Senji Shirasawa; Toshifumi Sakata
Anticancer research, Aug. 2020, 40(8):4687 - 4694, Refereed

A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells.
Yuuga Sawata; Taiji Matsukawa; Satoshi Doi; Toshiyuki Tsunoda; Nagisa Arikawa; Natsumi Matsunaga; Koichiro Ohnuki; Senji Shirasawa; Yojiro Kotake
Molecular and cellular biochemistry, Dec. 2019, 462(1-2):25 - 31

A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells.
Sawata Y; Matsukawa T; Doi S; Tsunoda T; Arikawa N; Matsunaga N; Ohnuki K; Shirasawa S; Kotake Y
Dec. 2019, 462(1-2):25 - 31, Refereed

Zfat Is Indispensable for the Development of Erythroid Cells in the Fetal Liver.
Keiko Doi; Toshiyuki Tsunoda; Midori Koyanagi; Yoko Tanaka; Shiori Yamano; Aya Fujikane; Kensuke Nishi; Shuhei Ishikura; Senji Shirasawa
Anticancer research, Aug. 2019, 39(8):4495 - 4502, Refereed

Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation.
Theodosia Charitou; Sriganesh Srihari; Miriam A Lynn; Mohamed-Ali Jarboui; Erik Fasterius; Max Moldovan; Senji Shirasawa; Toshiyuki Tsunoda; Marius Ueffing; Jianling Xie; Jin Xin; Xuemin Wang; Christopher G Proud; Karsten Boldt; Cristina Al-Khalili Szigyarto; Walter Kolch; David J Lynn
British journal of cancer, Jul. 2019, 121(1):37 - 50, Refereed

Acquisition of resistance to vemurafenib leads to interleukin-10 production through an aberrant activation of Akt in a melanoma cell line.
Takashi Inozume; Toshiyuki Tsunoda; Takashi Morisaki; Kazutoshi Harada; Seiji Shirasawa; Tatsuyoshi Kawamura
The Journal of dermatology, Dec. 2018, 45(12):1434 - 1439, Refereed

Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis.
Toshiyuki Tsunoda; Keiko Doi; Shuhei Ishikura; Hao Luo; Kensuke Nishi; Hiroshi Matsuzaki; Midori Koyanagi; Yoko Tanaka; Tadashi Okamura; Senji Shirasawa
International journal of molecular medicine, Nov. 2018, 42(5):2595 - 2603, Refereed

Growth Suppression of Human Colorectal Cancer Cells with Mutated KRAS by 3-Deaza-cytarabine in 3D Floating Culture.
Hao Luo; Kensuke Nishi; Shuhei Ishikura; Anthony Swain; Naoyuki Morishige; Ryo Yazaki; Takashi Ohshima; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Jul. 2018, 38(7):4247 - 4256, Refereed

A novel resveratrol derivative selectively inhibits the proliferation of colorectal cancer cells with KRAS mutation.
Haruna Okamoto; Taiji Matsukawa; Satoshi Doi; Toshiyuki Tsunoda; Yuuga Sawata; Madoka Naemura; Koichiro Ohnuki; Senji Shirasawa; Yojiro Kotake
Molecular and cellular biochemistry, 01 May 2018, 442(1-2):39 - 45, Refereed

The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation.
Madoka Naemura; Masahide Kuroki; Toshiyuki Tsunoda; Nagisa Arikawa; Yuuga Sawata; Senji Shirasawa; Yojiro Kotake
Anticancer research, 01 Jan. 2018, 38(1):77 - 81, Refereed

ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line.
Kensuke Nishi; Yuri Iwaihara; Toshiyuki Tsunoda; Keiko Doi; Toshifumi Sakata; Senji Shirasawa; Shuhei Ishikura
Cell death & disease, 14 Dec. 2017, 8(12):3218 - 3218, Refereed

Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS.
Kensuke Nishi; Hao Luo; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Lauren Wills; George S Baillie; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Jul. 2017, 37(7):3833 - 3839, Refereed

An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.
Kensuke Nishi; Hao Luo; Kazuhiko Nakabayashi; Keiko Doi; Shuhei Ishikura; Yuri Iwaihara; Yasuhiro Yoshida; Kumpei Tanisawa; Tomio Arai; Seijiro Mori; Motoji Sawabe; Masaaki Muramatsu; Masashi Tanaka; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Jul. 2017, 37(7):3855 - 3862, Refereed

Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells.
Shuhei Ishikura; Toshiyuki Tsunoda; Kazuhiko Nakabayashi; Keiko Doi; Midori Koyanagi; Keiko Hayashi; Tomoko Kawai; Yoko Tanaka; Yuri Iwaihara; Hao Luo; Kensuke Nishi; Tadashi Okamura; Senji Shirasawa
Biochimica et biophysica acta, Nov. 2016, 1859(11):1398 - 1410, Refereed

Oncogenic Ras influences the expression of multiple lncRNAs.
Yojiro Kotake; Madoka Naemura; Kyoko Kitagawa; Hiroyuki Niida; Toshiyuki Tsunoda; Senji Shirasawa; Masatoshi Kitagawa
Cytotechnology, Aug. 2016, 68(4):1591 - 6, Refereed

The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway.
Shuhei Ishikura; Yuri Iwaihara; Yoko Tanaka; Hao Luo; Kensuke Nishi; Keiko Doi; Midori Koyanagi; Tadashi Okamura; Toshiyuki Tsunoda; Senji Shirasawa
The Journal of biological chemistry, 15 Jul. 2016, 291(29):15282 - 91, Refereed

Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells.
Hao Luo; Masayo Umebayashi; Keiko Doi; Takashi Morisaki; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Jul. 2016, 36(7):3585 - 9, Refereed

Synthesis of New Congeners of 1-methyl-3-aminoisoquinolines, Evaluation of Their Cytotoxic Activity, In Silico and In Vitro Study of Their Molecular Targets as PDE4B.
Gennady B Lapa; Toshiyuki Tsunoda; Senji Shirasawa; Maria A Baryshnikova; Gregory G Evseev; Daria A Afanasyeva; Elena A Chigorina
Chemical biology & drug design, Apr. 2016, 87(4):575 - 82, Refereed

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells
Maria Goulielmaki; Evangelos Koustas; Eirini Moysidou; Margarita Vlassi; Takehiko Sasazuki; Senji Shirasawa; George Zografos; Eftychia Oikonomou; Alexander Pintzas
ONCOTARGET, Feb. 2016, 7(8):9188 - 9221, Refereed

Oncogenic Ras influences the expression of multiple lncRNAs.
Kotake Y; Naemura M; Kitagawa K; Niida H; Tsunoda T; Shirasawa S; Kitagawa M
Cytotechnology, 2016, 68(4):1591 - 1596, Refereed

ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture.
Madoka Naemura; Toshiyuki Tsunoda; Yasutoshi Inoue; Haruna Okamoto; Senji Shirasawa; Yojiro Kotake
Molecular and cellular biochemistry, Jan. 2016, 412(1-2):141 - 6, Refereed

Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells.
Yuri Iwaihara; Shuhei Ishikura; Keiko Doi; Toshiyuki Tsunoda; Takahiro Fujimoto; Tadashi Okamura; Senji Shirasawa
Anticancer research, Aug. 2015, 35(8):4419 - 23, Refereed

Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules.
Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Hiromasa Hidesima; Hao Luo; Yumiko Hirose; Senji Shirasawa
Anticancer research, Aug. 2015, 35(8):4453 - 9, Refereed

Zfat-deficient CD4⁺ CD8⁺ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.
Shuhei Ishikura; Masahiro Ogawa; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Yoko Tanaka; Toshiyuki Tsunoda; Hiromasa Hideshima; Tadashi Okamura; Senji Shirasawa
Journal of cellular biochemistry, Jan. 2015, 116(1):149 - 57, Refereed

Resveratrol induces luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture.
Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Senji Shirasawa
Anticancer research, Aug. 2014, 34(8):4551 - 5, Refereed

Zfat-Deficiency Results in a Loss of CD3ζ Phosphorylation with Dysregulation of ERK and Egr Activities Leading to Impaired Positive Selection
Masahiro Ogawa; Tadashi Okamura; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yoko Tanaka; Takeharu Ota; Kunihiro Hayakawa; Harumi Suzuki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
PLoS ONE, 03 Oct. 2013, 8(10):e76254, Refereed

Roles of ZFAT in Haematopoiesis, Angiogenesis and Cancer Development
Toshiyuki Tsunoda; Senji Shirasawa
ANTICANCER RESEARCH, Jul. 2013, 33(7):2833 - 2837, Refereed

ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response
Keiko Doi; Takahiro Fujimoto; Tadashi Okamura; Masahiro Ogawa; Yoko Tanaka; Yasumasa Mototani; Motohito Goto; Takeharu Ota; Hiroshi Matsuzaki; Masahide Kuroki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2012, 425(1):107 - 112, Refereed

Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model
Toshiyuki Tsunoda; Takeharu Ota; Takahiro Fujimoto; Keiko Doi; Yoko Tanaka; Yasuhiro Yoshida; Masahiro Ogawa; Hiroshi Matsuzaki; Masato Hamabashiri; Darren R. Tyson; Masahide Kuroki; Shingo Miyamoto; Senji Shirasawa
MOLECULAR CANCER, Jul. 2012, 11(1):46, Refereed

KRAS Up-regulates the Expression of miR-181a, miR-200c and miR-210 in a Three-dimensional-specific Manner in DLD-1 Colorectal Cancer Cells
Takeharu Ota; Keiko Doi; Takahiro Fujimoto; Yoko Tanaka; Masahiro Ogawa; Hiroshi Matsuzaki; Masahide Kuroki; Shingo Miyamoto; Senji Shirasawa; Toshiyuki Tsunoda
ANTICANCER RESEARCH, Jun. 2012, 32(6):2271 - 2275, Refereed

ALPK2 is Crucial for Luminal Apoptosis and DNA Repair-related Gene Expression in a Three-dimensional Colonic-crypt Model
Yasuhiro Yoshida; Toshiyuki Tsunoda; Keiko Doi; Takahiro Fujimoto; Yoko Tanaka; Takeharu Ota; Masahiro Ogawa; Hiroshi Matsuzaki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
ANTICANCER RESEARCH, Jun. 2012, 32(6):2301 - 2308, Refereed

Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes
Hiroshi Matsuzaki; Takahiro Fujimoto; Takeharu Ota; Masahiro Ogawa; Toshiyuki Tsunoda; Keiko Doi; Masato Hamabashiri; Masatoshi Tanaka; Senji Shirasawa
FEBS OPEN BIO, 2012, 2:255 - 259, Refereed

Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer
Yasuhiro Tada; Akira Yokomizo; Masaki Shiota; Toshiyuki Tsunoda; Christoph Plass; Seiji Naito
International Journal of Oncology, Sep. 2011, 39(3):727 - 733

Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells
Toshiyuki Tsunoda; Yasuo Takashima; Yasuhiro Yoshida; Keiko Doi; Yoko Tanaka; Takahiro Fujimoto; Takashi Machida; Takeharu Ota; Midori Koyanagi; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
ANTICANCER RESEARCH, Jul. 2011, 31(7):2453 - 2459, Refereed

KRAS-mediated Up-regulation of RRM2 Expression Is Essential for the Proliferation of Colorectal Cancer Cell Lines
Yasuhiro Yoshida; Toshiyuki Tsunoda; Keiko Doi; Yoko Tanaka; Takahiro Fujimoto; Takashi Machida; Takeharu Ota; Midori Koyanagi; Yasuo Takashima; Takehiko Sasazuki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
ANTICANCER RESEARCH, Jul. 2011, 31(7):2535 - 2539, Refereed

KRAS-induced actin-interacting protein regulates inositol 1,4,5-trisphosphate-receptor-mediated calcium release
Takahiro Fujimoto; Takashi Machida; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Masahide Kuroki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2011, 408(2):214 - 217, Refereed

Determination of the critical region of KRAS-induced actin-interacting protein for the interaction with inositol 1,4,5-trisphosphate receptor
Takahiro Fujimoto; Takashi Machida; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Masahide Kuroki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2011, 408(2):282 - 286, Refereed

Enhanced S100 calcium-binding protein P expression sensitizes human bladder cancer cells to cisplatin
Masaki Shiota; Toshiyuki Tsunoda; YooHyun Song; Akira Yokomizo; Yasuhiro Tada; Yoshinao Oda; Seiji Naito
BJU INTERNATIONAL, Apr. 2011, 107(7):1148 - 1153, Refereed

KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells
Takahiro Fujimoto; Takashi Machida; Yoko Tanaka; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Tadashi Okamura; Masahide Kuroki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2011, 407(2):438 - 443, Refereed

ZFAT IS A CRITICAL MOLECULE FOR CELL SURVIVAL IN MOUSE EMBRYONIC FIBROBLASTS
Keiko Doi; Takahiro Fujimoto; Midori Koyanagi; Toshiyuki Tsunoda; Yoko Tanaka; Yasuhiro Yoshida; Yasuo Takashima; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
CELLULAR & MOLECULAR BIOLOGY LETTERS, Mar. 2011, 16(1):89 - 100, Refereed

ZFAT is essential for endothelial cell assembly and the branch point formation of capillary-like structures in an angiogenesis model
Yasuhiro Yoshida; Toshiyuki Tsunoda; Yasuo Takashima; Takahiro Fujimoto; Keiko Doi; Takehiko Sasazuki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
CELLULAR & MOLECULAR BIOLOGY LETTERS, Dec. 2010, 15(4):541 - 550, Refereed

Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands
Toshiyuki Tsunoda; Yasuo Takashima; Yoko Tanaka; Takahiro Fujimoto; Keiko Doi; Yumiko Hirose; Midori Koyanagi; Yasuhiro Yoshida; Tadashi Okamura; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2010, 107(32):14199 - 14204, Refereed

Three-dimensionally Specific Inhibition of DNA Repair-Related Genes by Activated KRAS in Colon Crypt Model
Toshiyuki Tsunoda; Yasuo Takashima; Takahiro Fujimoto; Midori Koyanagi; Yasuhiro Yoshida; Keiko Doi; Yoko Tanaka; Tanaka; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
NEOPLASIA, May 2010, 12(5):397 - U5, Refereed

Osteoblast-specific Factor 2 Expression in Prostate Cancer-associated Stroma: Identification Through Microarray Technology
Bungo Furusato; Toshiyuki Tsunoda; Syed Shaheduzzaman; Martin E. Nau; Maryanne Vahey; Gyorgy Petrovics; David G. McLeod; Seiji Naito; Senji Shirasawa; Shiv Srivastava; Isabell A. Sesterhenn
UROLOGY, Apr. 2010, 75(4):768 - 772, Refereed

The Increased Expression of Periostin During Early Stages of Prostate Cancer and Advanced Stages of Cancer Stroma
Toshiyuki Tsunoda; Bunjo Furusato; Yasuo Takashima; Suma Ravulapalli; Albert Dobi; Shiv Srivastava; David G. McLeod; Isabell A. Sesterhenn; David K. Ornstein; Senji Shirasawa
PROSTATE, Sep. 2009, 69(13):1398 - 1403, Refereed

ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells
Takahiro Fujimoto; Keiko Doi; Midori Koyanagi; Toshiyuki Tsunoda; Yasuo Takashima; Yasuhiro Yoshida; Takehiko Sasazuki; Senji Shirasawa
FEBS LETTERS, Feb. 2009, 583(3):568 - 572, Refereed

Altered Energy Homeostasis and Resistance to Diet-Induced Obesity in KRAP-Deficient Mice
Takahiro Fujimoto; Kyoko Miyasaka; Midori Koyanagi; Toshiyuki Tsunoda; Iwai Baba; Keiko Doi; Minoru Ohta; Norihiro Kato; Takehiko Sasazuki; Senji Shirasawa
PLOS ONE, Jan. 2009, 4(1):e4240, Refereed

Functional analysis of ZFAT through specific siRNA against ZFAT in Ba/F3 cell line.
Midori Koyanagi; Keiko Doi; Takahiro Fujimoto; Toshiyuki Tsunoda; Yasuo Takashima; Senji Shirasawa
Medical Bulletin of Fukuoka University, 2008, 35(4):187 - 191, Refereed

Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation InVitro: Role of extracellular calcium
Darren R. Tyson; Junichi Inokuchi; Toshiyuki Tsunoda; Alice Lau; David K. Ornstein
PROSTATE, Nov. 2007, 67(15):1601 - 1613, Refereed

A novel mechanism of nuclear factor ・B activation through the binding between inhibitor of nuclear factor-・Bτ and the processed NH2-terminal region of Mig-6
Tsunoda T; Inokuchi J; Baba I; Okumura K; Naito S; Sasazuki T; Shirasawa S
Cancer Research, 2002, 62(20):5668 - 5671

新規レスベラトロール誘導体は大腸癌細胞三次元増殖を抑制する
澤田 悠賀; 松川 泰治; 土井 聡; 角田 俊之; 岡本 春奈; 苗村 円佳; 田原 圭一郎; 有川 和沙; 松岡 耕平; 原田 正樹; 大貫 宏一郎; 白澤 専二; 神武 洋二郎
生命科学系学会合同年次大会, Dec. 2017, 2017年度:[3P - 1297]

Comparative analysis of gene expression sigunatures of 3-d culture specific genes and epithelial specific genes from clinicaly localized human prostate normal and cancer specimens
Toshiyuki Tsunoda; Bungo Furusato; Seiji Naito; Suma Ravulapalli; Albert Dobi; Shiv Srivastava; Junichi Lnokuchi; Darren R. Tyson; David K. Ornstein; Isabell A. Sesterhenn
JOURNAL OF UROLOGY, Apr. 2008, 179(4):424 - 424

アスペルギルスと細菌の微生物間インタラクション解析による重複感染病態の解明と制御
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
長崎大学
01 Apr. 2023 - 31 Mar. 2026

新規抗腫瘍薬を利用した腫瘍免疫微小環境におけるKRAS制御機構の解明と制御法開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2021 - 31 Mar. 2024

EmmprinとCD73の結合阻害薬を開発するための基盤研究
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2021 - 31 Mar. 2024

接着性浸潤性大腸菌(AIEC)関連分子による炎症誘導大腸癌発症メカニズムの解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
International University of Health and Welfare
01 Apr. 2020 - 31 Mar. 2023

アスペルギルスと非結核性抗酸菌の細胞間コミュニケーションを介した難治化機序の解明
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
長崎大学
01 Apr. 2020 - 31 Mar. 2023

大腸癌細胞塊における生体内類似変異KRAS制御シグナルの解明及び阻害剤の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2018 - 31 Mar. 2021

潰瘍性大腸炎を起点とする炎症促進性因子を介した造腫瘍機械の解明と臨床応用
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2017 - 31 Mar. 2020

変異KRASが制御する微小環境と発癌分子機構の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2015 - 31 Mar. 2018

膵臓癌特異的な微小環境構築能に対する変異KRAS関連シグナル阻害剤の開発
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2016 - 31 Mar. 2017

微小乳頭状および簇出型浸潤様式の機序に関する包括的研究
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2016

肺癌における変異ＫＲＡＳ制御末梢分泌型ｍｉｃｒｏＲＮＡの解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2015

免疫疾患関連転写因子ＺＦＡＴのコンディショナルノックアウトマウスを用いた機能解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2015

変異ＫＲＡＳを起点とした大腸癌フィールドエフェクトの解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2015

3次元培養を用いた前立腺癌新規バイオマーカーの検索
日本学術振興会, 科学研究費助成事業, 若手研究(B)
九州大学
2007 - 2009