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Last Updated :2025/05/11

Akinori Shimizu

School of Medicine
Lecturer/Senior Assistant Professor

Researcher information

■ Degree
  • 博士（理学）, 筑波大学
■ Research Keyword
  • Golgi apparatus
  • Endoplasmic reticulum
  • Organelle
  • Mitochondrion
  • Reverse genetics
  • Genetic engineering
  • Chlamydia sp.
  • NLRP inflammasomes
■ Field Of Study
  • Life sciences, Molecular biology, Immunity
  • Life sciences, Laboratory animal science, Microbiology
  • Life sciences, Molecular biology, Molecular biology
  • Life sciences, Cell biology, Cell biology

Career

■ Career
  • 01 Apr. 2016
    Fukuoka University, Department of Microbiology and Immunology, Faculty of Medicine, assistant professor
■ Educational Background
  • 01 Apr. 2014 - 31 Mar. 2016
    University of Tsukuba, Graduate School of Life and Environmental Sciences, Doctoral's Program in Biological Sciences
  • 01 Apr. 2011 - 31 Mar. 2014
    University of Tsukuba, Graduate School of Life and Environmental Sciences, Master's Program in Biological Sciences
  • 01 Apr. 2007 - 31 Mar. 2011
    University of Tsukuba, School of Life and Environmental Sciences, College of Biological Sciences

Research activity information

■ Award
  • 25 Mar. 2016
    筑波大学大学院 生命環境科学研究科, 研究科長表彰
    ミトコンドリアにコードされたtRNA(Lys)に点突然変異を有するミトコンドリア病モデルマウスの作出及び病態解析, Others
    清水 章文
  • Dec. 2015
    日本ミトコンドリア学会, 若手優秀発表賞
    ミトコンドリアコードのtRNAに病原性突然変異を有するミトコンドリア病モデルマウスの作出及び病態解析, Japan society
    清水 章文;三藤 崇行;榎 俊慧;小笠原 絵美;橋爪 脩;長島 瑠子;石川 香;中田 和人;林 純一
  • 25 Mar. 2014
    筑波大学大学院 生命環境科学研究科 生物科学専攻, 専攻長表彰
    ミトコンドリアtRNA遺伝子に病原性突然変異を有するミトコンドリア病モデルマウスの作出, Others
    清水 章文
  • Dec. 2012
    日本ミトコンドリア学会, 研究奨励賞
    マウス培養細胞を用いた病原性突然変異型mtDNAを有する新規mito-miceの作出, Japan society
    清水章文;木場隆介;中田和人;林純一
■ Paper
  • Chlamydia trachomatis targets mitochondrial dynamics to promote intracellular survival and proliferation.
    Yusuke Kurihara; Ryota Itoh; Akinori Shimizu; Nirwana Fitriani Walenna; Bin Chou; Kazunari Ishii; Toshinori Soejima; Aya Fujikane; Kenji Hiromatsu
    Cellular Microbiology, 12 Oct. 2018, 21(1):e12962, Refereed
  • Chlamydia pneumoniae exploits adipocyte lipid chaperone FABP4 to facilitate fat mobilization and intracellular growth in murine adipocytes
    Nirwana Fitriani Walenna; Yusuke Kurihara; Bin Chou; Kazunari Ishii; Toshinori Soejima; Ryota Itoh; Akinori Shimizu; Takeshi Ichinohe; Kenji Hiromatsu
    Biochemical and Biophysical Research Communications, 01 Jan. 2018, 495(1):353 - 359, Refereed
  • Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice
    Akinori Shimizu; Haruna Tani; Gaku Takibuchi; Kaori Ishikawa; Ryota Sakurazawa; Takafumi Inoue; Tetsuo Hashimoto; Kazuto Nakada; Keizo Takenaga; Jun-Ichi Hayashi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2017, 493(1):252 - 257, Refereed
  • Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging
    Jun-Ichi Hayashi; Osamu Hashizume; Kaori Ishikawa; Akinori Shimizu
    CURRENT OPINION IN GENETICS & DEVELOPMENT, Jun. 2016, 38:63 - 67, Refereed
  • Mouse somatic mutation orthologous to MELAS A3302G mutation in the mitochondrial tRNA(Leu(UUR)) gene confers respiration defects
    Akinori Shimizu; Shunkei Enoki; Kaori Ishikawa; Takayuki Mito; Kanae Obata; Ruriko Nagashima; Hiromichi Yonekawa; Kazuto Nakada; Jun-Ichi Hayashi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2015, 467(4):1097 - 1102, Refereed
  • 核コードのGCAT遺伝子とSHMT2遺伝子のエピジェネティック制御がヒトの加齢にともなうミトコンドリア呼吸欠損を誘発する.
    清水章文; 橋爪 脩; 三藤崇行; 林 純一
    細胞工学, Nov. 2015, 34(11):1078 - 1079
  • Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects (vol 5, 10434, 2015)
    Osamu Hashizume; Sakiko Ohnishi; Takayuki Mito; Akinori Shimizu; Kaori Ishikawa; Kazuto Nakada; Manabu Soda; Hiroyuki Mano; Sumie Togayachi; Hiroyuki Miyoshi; Keisuke Okita; Jun-Ichi Hayashi
    SCIENTIFIC REPORTS, Oct. 2015, 5:14591, Refereed
  • A somatic T15091C mutation in the Cytb gene of mouse mitochondrial DNA dominantly induces respiration defects
    Chisato Hayashi; Gaku Takibuchi; Akinori Shimizu; Takayuki Mito; Kaori Ishikawa; Kazuto Nakada; Jun-Ichi Hayashi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2015, 463(4):1021 - 1027, Refereed
  • G7731A mutation in mouse mitochondrial tRNA(LYs) regulates late-onset disorders in transmitochondrial mice
    Akinori Shimizu; Takayuki Mito; Osamu Hashizume; Hiromichi Yonekawa; Kaori Ishikawa; Kazuto Nakada; Jun-ichi Hayashi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2015, 459(1):66 - 70, Refereed
  • Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA(Lys) gene
    Akinori Shimizu; Takayuki Mito; Chisato Hayashi; Emi Ogasawara; Ryusuke Koba; Issei Negishi; Keizo Takenaga; Kazuto Nakada; Jun-Ichi Hayashi
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2014, 111(8):3104 - 3109, Refereed
  • Selection of Rodent Species Appropriate for mtDNA Transfer to Generate Transmitochondrial Mito-Mice Expressing Mitochondria! Respiration Defects
    Shunkei Enoki; Akinori Shimizu; Chisato Hayashi; Hirotake Imanishi; Osamu Hashizume; Kazuyuki Mekada; Hitoshi Suzuki; Tetsuo Hashimoto; Kazuto Nakada; Jun-Ichi Hayashi
    EXPERIMENTAL ANIMALS, Jan. 2014, 63(1):21 - 30, Refereed
  • Mitochondrial DNA Mutations in Mutator Mice Confer Respiration Defects and B-Cell Lymphoma Development
    Takayuki Mito; Yoshiaki Kikkawa; Akinori Shimizu; Osamu Hashizume; Shun Katada; Hirotake Imanishi; Azusa Ota; Yukina Kato; Kazuto Nakada; Jun-Ichi Hayashi
    PLOS ONE, Feb. 2013, 8(2):e55789, Refereed
  • Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development
    Osamu Hashizume; Akinori Shimizu; Mutsumi Yokota; Atsuko Sugiyama; Kazuto Nakada; Hiroyuki Miyoshi; Makiko Itami; Miki Ohira; Hiroki Nagase; Keizo Takenaga; Jun-Ichi Hayashi
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2012, 109(26):10528 - 10533, Refereed
  • Nuclear but Not Mitochondrial DNA Involvement in Respiratory Complex I Defects Found in Senescence-Accelerated Mouse Strain, SAMP8
    Hirotake Imanishi; Mutsumi Yokota; Masayuki Mori; Akinori Shimizu; Kazuto Nakada; Jun-Ichi Hayashi
    EXPERIMENTAL ANIMALS, Jul. 2011, 60(4):397 - 404, Refereed
■ Lectures, oral presentations, etc.
  • ミトコンドリアコードのtRNAに病原性突然変異を有するミトコンドリア病モデルマウスの作出及び病態解析
    清水章文; 三藤崇行; 小笠原絵美; 竹永啓三; 石川香; 中田和人; 林純一
    第38回日本分子生物学会年会, Dec. 2015
  • ミトコンドリアコードのtRNAに病原性突然変異を有するミトコンドリア病モデルマウスの作出及び病態解析
    清水章文; 三藤崇行; 小笠原絵美; 竹永啓三; 石川香; 中田和人; 林純一
    第38回日本分子生物学会年会, Dec. 2015
  • ミトコンドリアゲノムに病原性突然変異を有するミトコンドリア病モデルマウスの作出及び病態解析
    清水章文; 三藤崇行; 小笠原絵美; 石川香; 中田和人; 林純一
    YoungMito, Jul. 2015, 中田和人
  • ミトコンドリアtRNA遺伝子に突然変異を有する新奇ミトコンドリア病モデルマウスの樹立
    清水章文; 三藤崇行; 林千彩音; 小笠原絵美; 竹永啓三; 石川香; 中田和人; 林純一
    日本ミトコンドリア学会第14回年会, Dec. 2014
  • ミトコンドリアtRNA遺伝子に突然変異を有するミトコンドリア病モデルマウスの樹立
    清水章文; 三藤崇行; 林千彩音; 小笠原絵美; 木場隆介; 根岸一星; 竹永啓三; 中田和人; 林純一
    第61回日本実験動物学会総会, May 2014
  • マウス培養細胞を用いた病原性突然変異を有する新規mito-miceの作出
    清水章文; 木場隆介; 中田和人; 林純一
    日本ミトコンドリア学会第12回年会, Dec. 2012