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Last Updated :2024/11/01



Department of Phatmaceutics
Assistant Lecturer/Assistant professor

Researcher information

■ Degree
  • 薬学博士, 福岡大学
■ Research Keyword
  • Chronic Obstructive Pulmonary Disease
  • エクソソーム
  • 血液脳関門
■ Field Of Study
  • Life sciences, Clinical pharmacy, Medical pharmacy
  • Life sciences, Pharmacology, Pharmacology in pharmacy

Career

■ Career
  • 01 Oct. 2017
    Fukuoka University, Faculty of Pharmaceutical Sciences, Research Associate
  • 01 Sep. 2015 - 31 Aug. 2017
    University of Washington, Postdoctoral Researcher
  • 01 Apr. 2009 - 31 Aug. 2015
    Fukuoka university, Faculty of Pharmaceutical Sciences, Research associate

Research activity information

■ Paper
  • Association of T cell infiltration and morphological change of thymus gland with the aggravation of pulmonary emphysema in testosterone deficiency.
    Kentaro Aono; Junichi Matsumoto; Taichi Matsumoto; Mitsuhisa Koga; Keisuke Migita; Koji Tominaga; Shinsuke Nakagawa; Atsushi Yamauchi
    Biochemistry and biophysics reports, Jul. 2023, 34:101489 - 101489
  • Bortezomib Increased Vascular Permeability by Decreasing Cell-Cell Junction Molecules in Human Pulmonary Microvascular Endothelial Cells.
    Taichi Matsumoto; Junichi Matsumoto; Yuka Matsushita; Moeno Arimura; Kentaro Aono; Mikiko Aoki; Kazuki Terada; Masayoshi Mori; Yutaka Haramaki; Takuya Imatoh; Atsushi Yamauchi; Keisuke Migita
    International journal of molecular sciences, 29 Jun. 2023, 24(13)
  • Senescence in brain pericytes attenuates blood-brain barrier function in vitro: A comparison of serially passaged and isolated pericytes from aged rat brains.
    Takuro Iwao; Fuyuko Takata; Junichi Matsumoto; Yuki Goto; Hisataka Aridome; Miho Yasunaga; Miki Yokoya; Yasufumi Kataoka; Shinya Dohgu
    Biochemical and biophysical research communications, 19 Feb. 2023, 645:154 - 163
  • Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice.
    Takuro Iwao; Fuyuko Takata; Junichi Matsumoto; Hisataka Aridome; Miho Yasunaga; Miki Yokoya; Yasufumi Kataoka; Shinya Dohgu
    PloS one, 2023, 18(2):e0281946
  • Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
    Taira Matsuo; Rie Komori; Minami Nakatani; Shiori Ochi; Aya Yokota-Nakatsuma; Junichi Matsumoto; Fuyuko Takata; Shinya Dohgu; Yasuhiro Ishihara; Kouichi Itoh
    International journal of molecular sciences, 12 Jul. 2022, 23(14)
  • Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction
    Takata F; Nakagawa S; Matsumoto J; Dohgu S
    Front Cell Neurosci., 13 Sep. 2021, 15:661838, Refereed
  • Testosterone deficiency promotes the development of pulmonary emphysema in orchiectomized mice exposed to elastase.
    Aono K; Matsumoto J; Nakagawa S; Matsumoto T; Koga M; Migita K; Tominaga K; Sakai Y; Yamauchi A
    Biochem Biophys Res Commun., 18 Jun. 2021, 558:94 - 101, Refereed
  • Serum amyloid A-induced blood-brain barrier dysfunction associated with decreased claudin-5 expression in rat brain endothelial cells and its inhibition by high-density lipoprotein in vitro
    Matsumoto J; Dohgu S; Takata F; Iwao T; Kimura I; Tomohiro M; Aono K; Kataoka Y; Yamauchi A
    Neurosci Lett., 22 Sep. 2020, 738:13552 - 135352, Refereed
    Lead
  • Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis.
    Sheng L; Stewart T; Yang D; Thorland E; Soltys D; Aro P; Khrisat T; Xie Z; Li N; Liu Z; Tian C; Bercow M; Matsumoto J; Zabetian CP; Peskind E; Quinn JF; Shi M; Zhang J
    Acta Neuropathol Commun., 08 Jul. 2020, 8(1):102, Refereed
  • Oncostatin-M-Reactive Pericytes Aggravate Blood-Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro.
    Takata F; Dohgu S; Sakaguchi S; Sakai K; Yamanaka G; Iwao T; Matsumoto J; Kimura I; Sezaki Y; Tanaka Y; Yamauchi A; Kataoka Y
    Neuroscience, Nov. 2019, 422:12 - 20, Refereed
  • Oligodendrocytes upregulate blood-brain barrier function through mechanisms other than the PDGF-BB/PDGFRα pathway in the barrier-tightening effect of oligodendrocyte progenitor cells
    Kimura I; Dohgu S; Takata F; Matsumoto J; Watanabe T; Iwao T; Yamauchi A; Kataoka Y
    Neurosci Lett., 13 Oct. 2019, 715:134594 - 134594, Refereed
  • Monomeric α-synuclein induces blood-brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro
    Dohgu S; Takata F; Matsumoto J; Kimura I; Yamauchi A; Kataoka Y
    Microvasc Res, 15 May 2019, 124:61 - 66, Refereed
  • Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells
    Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Yohei Kawahara; Megumi Nishihira; Shohei Sakada; Takuya Saisho; Atsushi Yamauchi; Yasufumi Kataoka
    Neurosci Lett., 16 Feb. 2019, 16(694):9 - 13, Refereed
  • Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro.
    Takata F; Dohgu S; Matsumoto J; Machida T; Sakaguchi S; Kimura I; Yamauchi A; Kataoka Y
    J Cell Biochem., Nov. 2018, 119(11):9055 - 9063
  • TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways
    Junichi Matsumoto; Shinya Dohgu; Fuyuko Takata; Takashi Machida; Funda F. Bölükbaşi Hatip; Izzettin Hatip-Al-Khatib; Atsushi Yamauchi; Yasufumi Kataoka
    Brain Research, 01 Aug. 2018, 1692:34 - 44
  • Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson’s disease.
    Nakashima A; Yamauchi A; Matsumoto J; Dohgu S; Takata F; Koga M; Fukae J; Tsuboi Y; Kataoka Y
    Behav Pharmacol, 25 May 2018, 30(1):89 - 94
  • Transmission of alpha-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease?
    Junichi Matsumoto; Tessandra Stewart; Lifu Sheng; Na Li; Kristin Bullock; Ning Song; Min Shi; William A. Banks; Jing Zhang
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, Sep. 2017, 5(1):71, Refereed
  • Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model
    Takashi Machida; Fuyuko Takata; Junichi Matsumoto; Tomoyuki Miyamura; Ryosuke Hirata; Ikuya Kimura; Yasufumi Kataoka; Shinya Dohgu; Atsushi Yamauchi
    PLOS ONE, May 2017, 12(5):e0177447
  • ROLE OF THROMBIN-PAR1-PKC theta/delta AXIS IN BRAIN PERICYTES IN THROMBIN-INDUCED MMP-9 PRODUCTION AND BLOOD-BRAIN BARRIER DYSFUNCTION IN VITRO
    Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Ikuya Kimura; Mariko Koga; Keiko Nakamoto; Atsushi Yamauchi; Yasufumi Kataoka
    NEUROSCIENCE, May 2017, 350:146 - 157, Refereed
  • The transport mechanism of extracellular vesicles at the blood-brain barrier.
    Matsumoto J; Stewart T; Banks WA; Zhang J
    Curr Pharm Des, 2017, 23(40):6206 - 6214, Refereed
  • Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood-brain barrier in vitro
    Takashi Machida; Fuyuko Takata; Junichi Matsumoto; Hisayo Takenoshita; Ikuya Kimura; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
    NEUROSCIENCE LETTERS, Jul. 2015, 599:109 - 114
  • Nifedipine Prevents Sodium Caprate-Induced Barrier Dysfunction in Human Epidermal Keratinocyte Cultures
    Yoshihiro Uchino; Junichi Matsumoto; Takuya Watanabe; Masato Hamabashiri; Takashi Tsuchiya; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2015, 38(6):926 - 929, Refereed
  • Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons
    Hiroyuki Takahashi; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2015, 457(4):532 - 537
  • Tumor necrosis factor-α reduces beta-amyloid accumulation primarily by lowering cellular prion protein levels in a brain endothelial cell line.
    Yasutaka Y; Watanabe T; Nakashima A; Matsumoto J; Futagami K; Yamauchi A; Kataoka Y
    FEBS Lett, Dec. 2014, Refereed
  • Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation
    Junichi Matsumoto; Fuyuko Takata; Takashi Machida; Hiroyuki Takahashi; Yuki Soejima; Miho Funakoshi; Koujiro Futagami; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
    NEUROSCIENCE LETTERS, Aug. 2014, 578:133 - 138, Refereed
  • Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells
    Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Takashi Machida; Shuji Kaneshima; Mai Matsuo; Shinya Sakaguchi; Yuki Takeshige; Atsushi Yamauchi; Yasufumi Kataoka
    Biochemical and Biophysical Research Communications, 19 Apr. 2013, 433(4):586 - 590, Refereed
  • In Vitro Blood-Brain Barrier Models Using Brain Capillary Endothelial Cells Isolated from Neonatal and Adult Rats Retain Age-Related Barrier Properties
    Fuyuko Takata; Shinya Dohgu; Atsushi Yamauchi; Junichi Matsumoto; Takashi Machida; Kayoko Fujishita; Keisuke Shibata; Youichi Shinozaki; Kaoru Sato; Yasufumi Kataoka; Schuichi Koizumi
    PLoS ONE, 31 Jan. 2013, 8(1):e55166, Refereed
  • Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells
    Junichi Matsumoto; Shinya Dohgu; Fuyuko Takata; Tsuyoshi Nishioku; Noriko Sumi; Takashi Machida; Hiroyuki Takahashi; Atsushi Yamauchi; Yasufumi Kataoka
    NEUROSCIENCE LETTERS, Aug. 2012, 524(1):45 - 48, Refereed
  • Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro.
    Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Hiroyuki Takahashi; Takashi Machida; Tomoya Wakigawa; Eriko Harada; Haruki Miyaji; Mitsuhisa Koga; Tsuyoshi Nishioku; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF NEUROINFLAMMATION, Aug. 2011, 8(8):106, Refereed
  • Partial hepatectomy aggravates cyclosporin A-induced neurotoxicity by lowering the function of the blood-brain barrier in mice
    Atsushi Yamauchi; Shinya Dohgu; Fuyuko Takata; Takuya Watanabe; Tsuyoshi Nishioku; Junich Matsumoto; Yuka Ohkubo; Hideki Shuto; Yasufumi Kataoka
    LIFE SCIENCES, Mar. 2011, 88(11-12):529 - 534, Refereed
  • Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1
    Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Masatoshi Oda; Eriko Harada; Takuya Watanabe; Tsuyoshi Nishioku; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
    MICROVASCULAR RESEARCH, Jan. 2011, 81(1):103 - 107, Refereed
  • Medication use as a risk factor for inpatient falls in an acute care hospital: a case-crossover study
    Hideki Shuto; Osamu Imakyure; Junichi Matsumoto; Takashi Egawa; Ying Jiang; Masaaki Hirakawa; Yasufumi Kataoka; Takashi Yanagawa
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, May 2010, 69(5):535 - 542
  • Tumor necrosis factor-α mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells
    Tsuyoshi Nishioku; Junichi Matsumoto; Shinya Dohgu; Noriko Sumi; Kenji Miyao; Fuyuko Takata; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
    Journal of Pharmacological Sciences, 2010, 112(2):251 - 254, Refereed
  • Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia.
    Sumi N; Nishioku T; Takata F; Matsumoto J; Watanabe T; Shuto H; Yamauchi A; Dohgu S; Kataoka Y
    Cellular and molecular neurobiology., Mar. 2009, 30(2):247 - 253
■ MISC
  • COPDモデルマウスにおけるリポキシンA4に対するエストロゲンの影響
    冨永 宏治; 青野 健太郎; 松本 純一; 古賀 允久; 山内 淳史; 江川 孝; 片岡 泰文
    日本薬学会年会要旨集, Mar. 2020, 140年会:26Q - pm097
  • Nicotinic acetylcholine receptors modulate TNF-alpha-induced MMP-9 release from brain pericytes
    Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124:209P - 209P
  • Adenosine stimulates brain pericytes to release matrix metalloproteinase-9 through A3 adenosine receptor
    Makoto Shougakiuchi; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Yui Yamamoto; Haruka Aikawa; Satomi Nagata; Shinya Dohgu; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121:215P - 215P
  • Brain pericyte-derived soluble factors induce the blood-brain barrier dysfunction under pathological conditions
    Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Hiroyuki Takahashi; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121:25P - 25P
  • Alpha7 nicotinic acetylcholine receptor mediates MMP-9 release from brain pericytes
    Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takashi Machida; Atsushi Noriyuki; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121:215P - 215P
  • Brain pericytes contribute to the blood-brain barrier disruption induced by thrombin
    Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hisayo Takenoshita; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121:214P - 214P
  • Brain pericytes-specific TNF-alpha-induced MMP-9 release is mediated by ROS and delayed activation of ERK1/2 and Akt
    Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Haruki Miyaji; Yui Sonogi; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118:111P - 111P
  • Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-alpha, releasing matrix metalloproteinase-9 and migrating in vitro
    Fuyuko Takata; Shinya Dohgu; Junichi Matsumoto; Takashi Machida; Hiroyuki Takahashi; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118:112P - 112P
  • Brain pericytes prevent migration of the inflammatory cells across the blood-brain barrier
    Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Takashi Machida; Natsuko Ichiki; Natsuko Seki; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118:111P - 111P
  • Brain pericytes among BBB cells possess the most sensitive machinery of TNF-a - MMP-9 pathway due to high expression levels of TNF-R2 and long-lasting activation of ERK1/2 and Akt
    Haruki Miyaji; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Yui Sonogi; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:186P - 186P
  • TNF-alpha-induced release of IL-6 from brain pericytes through JAK/STAT signaling pathway
    Sayaka Tao; Junichi Matsumoto; Fuyuko Takata; Hiroyuki Takahashi; Manami Kawaguchi; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:176P - 176P
  • Brain pericytes release matrix metalloproteinase-9 in response to brain endothelial cells-derived ectonucleotidase CD39/ENTPDase1 under hypoxia/aglycemia condition
    Tatsuya Furuno; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Tomo Nanri; Atsushi Yamauchi; Shinya Dohgu; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:140P - 140P
  • Brain pericytes prevents migration of the inflammatory cells across the blood-brain barrier
    Natsuko Ichiki; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Hiroyuki Takahashi; Natsuko Seki; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:242P - 242P
  • Brain pericytes facilitate insulin-induced phosphorylation of Akt in the hypothalamic neuronal cells
    Hiroyuki Takahashi; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Takuya Watanabe; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115:189P - 189P
  • BBB hyperpermeability to sodium fluorescein in obese mice with impaired glucose tolerance induced by high-fat diet
    Fuyuko Takata; Shinya Dohgu; Takashi Obara; Junichi Matsumoto; Tsuyoshi Nishioku; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:127P - 127P
  • Calcineurin/NFAT signaling regulates MMP-9 expression in brain pericytes
    Takashi Machida; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Tatsuya Fruno; Shuji Kaneshima; Takuya Watanabe; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:55P - 55P
  • Reactive oxygen species (ROS)-mediated regulation of MMP-9 expression in the brain pericytes
    Kousuke Matsumoto; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Natsuko Ichiki; Sayaka Tao; Haruki Miyaji; Tsuyoshi Nishioku; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112:189P - 189P
  • Functional impact of RIMs on gating of voltage-dependent Ca2+channels
    Junichi Matsumoto; Noriko Sumi; Tsuyoshi Nishioku; Shinya Dohgu; Shinsuke Nakagawa; Atsushi Yamauchi; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109:159P - 159P
  • Involvement of the activated microglia in the induction of blood-brain barrier dysfunction
    Noriko Sumi; Tsuyoshi Nishioku; Kotoe Asano; Junichi Matsumoto; Shinsuke Nakagawa; Atsushi Yamauchi; Hideki Shuto; Masami Niwa; Yasufumi Kataoka
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106:126P - 126P
■ Lectures, oral presentations, etc.
  • 精巣摘出によるテストステロン欠乏はPPE誘発の肺気腫形成を加速させる
    青野 健太郎; 坂井 優菜; 松本 純一; 松本 太一; 三好 利奈; 右田 啓介; 道具 伸也; 山内 淳史
    日本薬学会第141年会, 26 Mar. 2021, 日本薬学会
  • テストステロン補充は精巣摘出マウスにおけるPPE誘発の肺気腫形成を抑制する
    坂井 優菜; 青野 健太郎; 松本 純一; 松本 太一; 三好 利奈; 右田 啓介; 道具 伸也; 山内 淳史
    日本薬学会第141年会, 26 Mar. 2021, 日本薬学会
  • ボルテゾミブはタイトジャンクションの破綻を介して血管透過性を亢進する
    松本 太一; 坂田 歩美; 松本 純一; 森山 英恵; 小野 和彦; 山内 淳史; 右田 啓介; 原 周司
    日本薬学会第141年会, 26 Mar. 2021, 日本薬学会
  • 加熱式たばこPloom TECH抽出物による血液脳関門障害
    道具 伸也; 木村 郁哉; 江口 夏海; 力武 真衣; 高田 芙友子; 松本 純一; 岩尾 卓朗; 片岡 泰文
    日本薬学会第141年会, 26 Mar. 2021, 日本薬学会
  • シクロスポリンによる脳ペリサイトのαシヌクレインオリゴマー分解促進
    道具 伸也; 横谷 みき; 高田 芙友子; 松本 純一; 岩尾 卓朗; 佐野 和憲; 片岡 泰文
    第94回日本薬理学会年会, 08 Mar. 2021, 日本薬理学会
  • 脳ペリサイトはアストロサイトのNa+依存性グルタミン酸取り込みを促進的に調節する
    高田 芙友子; 坂井 研太; 岩尾 卓朗; 松本 純一; 片岡 泰文; 山内 淳史; 道具 伸也
    第94回日本薬理学会年会, 08 Mar. 2021, 日本薬理学会
  • 血液脳関門(BBB)を介したドコサヘキサエン酸の脳移行は加齢マウスにおいて減少する。
    岩尾 卓朗; 髙田 芙友子; 松本 純一; 片岡 泰文; 道具 伸也
    第94回日本薬理学会年会, 08 Mar. 2021, 日本薬理学会
  • 精巣摘出マウスにおけるテストステロン欠乏はエラスターゼ気管支内投与後の死亡率 とアンチプロテアーゼの発現プロファイルに変化を与える
    青野 健太郎; 松本 純一; 三好 利奈; 坂井 優菜; 中川 慎介; 道具 伸也; 山内 淳史
    第73回日本薬理学会西南部会, 21 Nov. 2020, 日本薬理学会
  • 加齢により血液脳関門(BBB)を介したドコサヘキサエン酸の脳移行は減少する。
    岩尾 卓朗; 髙田 芙友子; 松本 純一; 片岡 泰文; 道具 伸也
    第73回日本薬理学会西南部会, 21 Nov. 2020, 日本薬理学会
  • COPDモデルマウスにおけるリポキシンA4に対するエストロゲンの影響
    冨永 宏治; 青野 健太郎; 松本 純一; 古賀 允久; 山内 淳史; 江川 孝; 片岡 泰文
    日本薬学会第140年会, 25 Mar. 2020, 日本薬学会
  • 脳ペリサイトによるα-シヌクレインオリゴマーの細胞内取り込み機構
    横谷 みき; 道具 伸也; 高田 芙友子; 松本 純一; 岩尾 卓朗; 山内 淳史; 佐野 和憲; 片岡 泰文
    日本薬学会第140年会, 25 Mar. 2020, 日本薬学会
  • Serum amyloid AはTLRsを介して脳ペリサイトの炎症応答を調節する
    松本 純一; 道具 伸也; 高田 芙友子; 岩尾 卓朗; 友廣 美咲; 平田 由佳; 青野 健太郎; 山内 淳史; 片岡 泰文
    日本薬学会第140年会, 25 Mar. 2020, 日本薬学会
  • Toll様受容体を介した脳ペリサイト特異的なαシヌクレインによる炎症性メディエーター産生
    道具 伸也; 秋月 美波; 小林 篤史; 盛田 隼矢; 高田 芙友子; 松本 純一; 岩尾 卓朗; 山内 淳史; 佐野 和憲; 片岡 泰文
    第93回日本薬理学会年会, 16 Mar. 2020, 日本薬理学会
  • Serum amyloid Aによる血液脳関門障害とHigh density lipoproteinによる抑制作用
    松本純一; 道具伸也; 高田芙友子; 岩尾卓朗; 友廣美咲; 片岡泰文; 山内淳史
    第72回日本薬理学会西南部会, 16 Nov. 2019, 日本薬理学会
  • An interaction between thrombin and pericytes mediates the blood-brain barrier dysfunction in obesity-associated diabetes.
    Fuyuko Takata; Shinya Dohgu; Takashi Machida; Junichi Matsumoto; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
    cerebral vascular biology,, 28 Nov. 2018
  • Lowered PDGF-BB/PDGFRb signaling between brain endothelial cells and pericyte contributes to the blood-brain barrier disruption induced by oxygen-glucose deprivation.
    Ikuya Kimura; Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Wakana Yoshida; Aya Yoshimatsu; Haruka Tanaka; Atsushi Yamauchi; Yasufumi Kataoka
    Cerebral Vascular Biology, 28 Nov. 2017
  • α-Synuclein-reactive pericytes contribute to the blood-brain barrier dysfunction through the release of inflammatory cytokines in vitro.
    Shinya Dohgu; Fuyuko Takata; Junichi Matsumoto; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
    Cerebral Vascular Biology, 28 Nov. 2017
  • 脳血管内皮細胞-ペリサイト細胞間PDGF-BB/PDGFRbシグナル減弱が低酸素・低グルコース誘発性血液脳関門機能障害に関与する
    木村郁哉; 道具伸也; 高田芙友子; 松本純一; 吉田若菜; 吉松あや; 田中春花; 山内淳史; 片岡泰文
    第70回日本薬理学会西南部会, Nov. 2017, 日本薬理学会
  • 脳微小血管内皮細胞の7 nAChR活性化は、TNF-α刺激による密着結合蛋白量及び障壁能の低下を抑制する
    木村郁哉; 道具伸也; 高田芙友子; 松本純一; 川原庸平; 西平恵; 坂田昇平; 最初拓也; 片岡泰文; 山内淳史
    第90回日本薬理学会年会, 17 Mar. 2017, 日本薬理学会
  • TNF-α-stimulated brain pericytes activate microglia to induce inflammation at the neurovascular unit
    Fuyuko Takata-Tsuji; Shinya Dohgu; Junichi Matsumoto; Ikuya Kimura; Atsushi Yamauchi; Yasufumi Kataoka
    19th International Symposium on signal transduction at the Blood-Brain Barriers, 14 Sep. 2016
  • AMPK活性化を介したメトホルミンの血液脳関門機能強化作用
    高田芙友子; 道具伸也; 松本純一; 町田崇; 山内淳史; 片岡泰文
    第3回日本くすりと糖尿病学会学術集会, 02 Nov. 2014
■ Affiliated academic society
  • 日本薬学会
  • 日本薬理学会
■ Research Themes
  • 慢性閉塞性肺疾患COPD併存うつ病の治療薬による原疾患増悪ジレンマのメカニズム
    日本学術振興会, 科学研究費助成事業, 基盤研究(C)
    福岡大学
    01 Apr. 2024 - 31 Mar. 2027
  • アンドロゲンシグナルから捉えるCOPD病態の解析と治療薬の探索
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
    福岡大学
    01 Apr. 2022 - 31 Mar. 2025
  • アンドロゲンを核とする内分泌系-肺-脳の臓器連関異常化によるCOPD病態増悪機構
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
    福岡大学
    01 Apr. 2021 - 31 Mar. 2024
  • 血管透過性亢進に起因するボルテゾミブ誘発性肺障害の発症機序解明
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
    Fukuoka University
    01 Apr. 2021 - 31 Mar. 2024
  • 腸炎症に起因した脳ペリサイト異常化が駆動する脳内αシヌクレインの凝集・蓄積亢進
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
    Fukuoka University
    01 Apr. 2019 - 31 Mar. 2022
  • エクソソームが駆動する慢性閉塞性肺疾患の血液脳関門病変化と薬剤中枢性副作用
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists
    Fukuoka University
    01 Apr. 2019 - 31 Mar. 2022
  • 肥満症による末梢慢性炎症の脳内伝播過程において「鍵」となる脳ペリサイトの病変化
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
    Fukuoka University
    01 Apr. 2014 - 31 Mar. 2018
  • 生活習慣病に起因する腸内細菌叢の変調・異常と脳内β-amyloid動態障害の解明
    ヤクルト・バイオサイエンス研究財団, 研究助成金
    01 Apr. 2015 - 31 Mar. 2016
  • 慢性閉塞性肺疾患の血液脳関門病変化とレニン・アンジオテンシン系阻害薬の保護作用
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), 基盤研究(C)
    Fukuoka University
    01 Apr. 2012 - 31 Mar. 2015
  • 脳ペリサイト産生シクロフィリンAによる脳インスリン抵抗性形成と糖尿病進展
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B)
    Fukuoka University
    2011 - 2013
  • 脳ペリサイト機能異常に起因した脳神経血管機構破綻による肥満症の進展
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B)
    Fukuoka University
    2009 - 2010