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Last Updated :2026/09/12

Takanaga Shirai

Department of Sports Science/Department of Health and Exercise Science
Assistant Lecturer/Assistant professor

Researcher information

■ Degree
  • Ph.D.(Health and Sorts Science), University of Tsukuba, Apr. 2021
■ Research Keyword
  • Mitochondria
  • Exerkine
  • Skeletal muscle
  • Exercise Physiology
  • Sports Science
■ Field Of Study
  • Life sciences, Sports science, 運動生理学

Career

■ Career
  • Jun. 2026 - Present
    University of Tsukuba, Faculty of Health and Sport Sciences, 客員研究員
  • Apr. 2026 - Present
    Fukuoka University, Division of Physical Education, 助教
  • Apr. 2026 - Present
    福岡大学, スポーツ科学部, 助教
  • Apr. 2023 - Mar. 2026
    独立行政法人日本学術振興会PD(神奈川大学)
  • Apr. 2022 - Mar. 2026
    成城大学, 社会イノベーション学部, 非常勤講師
  • Sep. 2021 - Mar. 2026
    法政大学, リベラルアーツセンター, 兼任講師
  • Apr. 2022 - Mar. 2023
    筑波大学, 体育系, 研究員
  • Apr. 2020 - Mar. 2022
    独立行政法人日本学術振興会DC2(筑波大学)
  • Apr. 2017 - Mar. 2018
    筑波大学, 体育系, 非常勤研究員
■ Educational Background
  • Mar. 2018 - Mar. 2021
    University of Tsukuba, 人間総合科学研究科, 体育科学専攻
  • Apr. 2015 - Mar. 2017
    University of Tsukuba, Graduate School of Comprehensive Human Sciences, 体育学専攻
  • Apr. 2014 - Mar. 2015
    University of Tsukuba, School of Health and Physical Education
  • 2010 - 2014
    Oita University, 教育福祉科学部, スポーツ健康分野
■ Member History
  • 2022 - Present
    Athleticoomics リサーチユニット, 筑波大学
  • 2022 - Present
    評議員, 日本運動生理学会
  • 2023
    事務局長, 第31回日本運動生理学会大会(つくば大会)

Research activity information

■ Award
  • 2026
    The Physiological Society, Physiological Reports Top viewed article *Among work published between 1 January 2024 - 31 December 2024.
  • Mar. 2025
    法政大学, 学生が選ぶベストティーチャー賞(教養部門)2024年
  • 2025
    第38回日本トレーニング科学会 若手研究奨励賞
  • 2024
    第37回日本トレーニング科学会 若手研究奨励賞(共同研究者)
  • 2024
    日本運動生理学会 第25回奨励賞
  • 2022
    The Physiological Society, Physiological Reports Most Cited Article *Among work published between 1 January 2022 - 31 December 2022.
  • 2022
    The Physiological Society, Physiological Reports Top Downloaded Article *Among work published between 1 January 2022 - 31 December 2022.
  • 2021
    The Physiological Society, Physiological Reports Top Downloaded Article *Among work published between 1 January 2021 - 31 December 2021.
  • 2020
    FEBS press, FEBS Open Bio Top Downloaded Article *Among work published between 1 January 2019 - 31 December 2020.
  • Sep. 2019
    日本体力医学会, 国際学術交流奨励賞
  • Sep. 2018
    日本体力医学会, 国際学術交流奨励賞
  • Sep. 2018
    日本体力医学会, 大塚スポーツ医・科学賞 奨励賞
■ Paper
  • Conserved skeletal muscle transcriptomic responses to pacing strategies in Thoroughbred horses.
    Kenya Takahashi; Kazutaka Mukai; Takanaga Shirai; Yusaku Ebisuda; Fumi Sugiyama; Toshinobu Yoshida; Hideo Hatta; Yu Kitaoka
    Biology open, 03 Jul. 2026
  • Effect of Denervation on Skeletal Muscle Mitochondria in Heterozygous mtDNA Mutator Mice.
    Takanaga Shirai; Hideto Hanakita; Kohei Takeda; Yu Kitaoka; Kaori Ishikawa; Kazuto Nakada; Tohru Takemasa
    FASEB bioAdvances, Feb. 2026, 8(2):e70088
  • Exercise modality-dependent mitochondrial respiratory capacity in satellite cells and conditioned serum-induced responses in cultured myotubes.
    Takanaga Shirai; Hayato Shinkai; Riku Tanimura; Kazuki Uemichi; Shunsuke Sugiyama; Kohei Takeda; Yu Kitaoka; Tohru Takemasa
    Experimental physiology, Jan. 2026, 111(1):226 - 239
  • Combined effects of high-intensity interval training in the form of swimming exercise and rapamycin-sensitive mTORC1 inhibition on mitochondrial adaptations in mouse skeletal muscles.
    Kazuki Uemichi; Takanaga Shirai; Hayato Shinkai; Ryoto Iwai; Tomohiro Iwata; Shunsuke Sugiyama; Tohru Takemasa
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 01 Jan. 2026, 51:1 - 18
  • Effect of Muscle Contraction Under Caloric Restriction on Irisin and FGF21 Secretion in Mice
    Riku Tanimura; Hiroyuki Watanabe; Takanaga Shirai; Kazuki Uemichi; Tomohiro Iwata; Tohru Takemasa
    PHYSIOLOGICAL RESEARCH, Dec. 2025, 74(6):969 - 980
  • Unilateral electrical stimulation of mice induces transcriptional response in stimulated leg with limited effect on non-stimulated contralateral leg.
    Takanaga Shirai; Kazuki Uemichi; Tohru Takemasa; Yu Kitaoka
    Experimental physiology, Sep. 2025, 110(9):1197 - 1202
  • Combined effects of mechanical overload and high-intensity interval training on skeletal muscle hypertrophy in male mice.
    Hayato Shinkai; Takanaga Shirai; Kazuki Uemichi; Ryoto Iwai; Tomohiro Iwata; Riku Tanimura; Shunsuke Sugiyama; Tohru Takemasa
    Physiological reports, Sep. 2025, 13(17):e70542
  • Transcriptomic responses of equine skeletal muscle to acute exercise in a hot environment.
    Kenya Takahashi; Takanaga Shirai; Kazutaka Mukai; Yusaku Ebisuda; Fumi Sugiyama; Toshinobu Yoshida; Yu Kitaoka
    Physiological genomics, 01 Aug. 2025, 57(8):450 - 455
  • Functional compounds oleuropein and hydroxytyrosol in olive leaves attenuate chronic kidney disease-induced muscle atrophy
    Takanaga Shirai; Akari Endo; Tohru Takemasa; Hitoshi Miyazaki
    The Journal of Nutritional Physiology, Jul. 2025
  • Development of Detection Method Using Dried Blood Spot with Next-Generation Sequencing and LabDroid for Gene Doping Control.
    Kiyoshi Maehara; Atsushi Hirokawa; Hinata Watanabe; Norihiro Otani; Jiawei Wan; Takanaga Shirai; Tohru Takemasa; Koichi Watanabe; Takeki Nishi; Ken Sato; Suzuka Shimmura; Kieu D M Nguyen; Yoichiro Takahashi; Takehito Sugasawa
    International journal of molecular sciences, 26 Jun. 2025, 26(13)
  • Systemic effect of combined functional overload and endurance-type swimming exercise on whole body metabolism in mice.
    Takanaga Shirai; Kazuki Uemichi; Ryoto Iwai; Hayato Shinkai; Tomohiro Iwata; Riku Tanimura; Shunsuke Sugiyama; Tohru Takemasa
    American journal of physiology. Endocrinology and metabolism, 01 May 2025, 328(5):E695-E710
  • Endurance swimming exacerbates mitochondrial myopathy in mice with high mtDNA deletions.
    Sho Hanada; Kaori Ishikawa; Takanaga Shirai; Tohru Takemasa; Kazuto Nakada
    Mitochondrion, Mar. 2025, 81:102010 - 102010
  • Effect of spermidine intake on overload-induced skeletal muscle hypertrophy in male mice.
    Tomohiro Iwata; Takanaga Shirai; Riku Tanimura; Ryoto Iwai; Tohru Takemasa
    Physiological reports, Feb. 2025, 13(3):e70209
  • Maslinic Acid Supplementation Suppressed Early Onset Muscle Soreness and Systemic Fatigue after Full Marathon: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Katsuyuki Tokinoya; Takanaga Shirai; Kazuki Uemichi; Shusaku Murata; Yuki Yamauchi; Shotaro Murata; Tohru Takemasa
    Journal of nutritional science and vitaminology, 2025, 71(5):448 - 455
  • Differential responses to acute endurance exercise-induced signaling protein phosphorylation and abundance alterations in whole murine gastrocnemius muscle and isolated myofibers.
    Kazuki Uemichi; Takanaga Shirai; Shunsuke Sugiyama; Tohru Takemasa
    Current research in physiology, 2025, 8:100173 - 100173
  • Effect of spermidine intake on skeletal muscle regeneration after chemical injury in male mice.
    Tomohiro Iwata; Takanaga Shirai; Kazuki Uemichi; Riku Tanimura; Tohru Takemasa
    Physiological reports, Oct. 2024, 12(20):e70092
  • Effects of maslinic acid supplementation on exercise-induced inflammation and oxidative stress in water polo athletes: A randomized, double-blind, crossover, and placebo-controlled trial.
    Takanaga Shirai; Kanae Myoenzono; Eiskue Kawai; Yuki Yamauchi; Keito Suzuki; Seiji Maeda; Hideki Takagi; Tohru Takemasa
    Journal of the International Society of Sports Nutrition, Dec. 2023, 20(1):2239196 - 2239196
  • The effect of serum from calorie-restricted mouse on mTOR signaling in C2C12 myotubes.
    Takanaga Shirai; Tomohiro Iwata; Kazuki Uemichi; Riku Tanimura; Ryoto Iwai; Tohru Takemasa
    The Journal of endocrinology, 01 Nov. 2023, 259(2)
  • Effects of the order of endurance and high-intensity interval exercise in combined training on mouse skeletal muscle metabolism.
    Takanaga Shirai; Kazuki Uemichi; Tohru Takemasa
    American journal of physiology. Regulatory, integrative and comparative physiology, 01 Nov. 2023, 325(5):R593-R603
  • Combined effects of functional overload and denervation on skeletal muscle mass and its regulatory proteins in mice.
    Kazuki Uemichi; Takanaga Shirai; Tohru Takemasa
    Physiological reports, May 2023, 11(9):e15689
  • The role of the mechanistic target of rapamycin complex 1 in the regulation of mitochondrial adaptation during skeletal muscle atrophy under denervation or calorie restriction in mice.
    Kazuki Uemichi; Takanaga Shirai; Ryunosuke Matsuno; Tomohiro Iwata; Riku Tanimura; Tohru Takemasa
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 01 Mar. 2023, 48(3):241 - 255
  • Effects of lactate administration on hypertrophy and mTOR signaling activation in mouse skeletal muscle.
    Takanaga Shirai; Yu Kitaoka; Kazuki Uemichi; Katsuyuki Tokinoya; Kohei Takeda; Tohru Takemasa
    Physiological reports, Aug. 2022, 10(16):e15436
  • Effects of exercise intensity on white adipose tissue browning and its regulatory signals in mice.
    Riku Tanimura; Leo Kobayashi; Takanaga Shirai; Tohru Takemasa
    Physiological reports, Mar. 2022, 10(5):e15205
  • Effect of the order of concurrent training combined with resistance and high-intensity interval exercise on mTOR signaling and glycolytic metabolism in mouse skeletal muscle.
    Takanaga Shirai; Hideto Hanakita; Kazuki Uemichi; Tohru Takemasa
    Physiological reports, Mar. 2021, 9(5):e14770
  • Effect of mechanistic/mammalian target of rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy.
    Kazuki Uemichi; Takanaga Shirai; Hideto Hanakita; Tohru Takemasa
    Physiological reports, Mar. 2021, 9(5):e14789
  • Effect of endurance exercise duration on muscle hypertrophy induced by functional overload.
    Takanaga Shirai; Tsubasa Obara; Tohru Takemasa
    FEBS open bio, Jan. 2021, 11(1):85 - 94
  • Maslinic Acid Promotes Hypertrophy Induced by Functional Overload in Mouse Skeletal Muscle.
    Takanaga Shirai; Kazuki Uemichi; Kakeru Kubota; Yuki Yamauchi; Tohru Takemasa
    Journal of nutritional science and vitaminology, 2021, 67(5):317 - 322
  • Effect of lactate administration on mouse skeletal muscle under calorie restriction.
    Takanaga Shirai; Kazuki Uemichi; Yuki Hidaka; Yu Kitaoka; Tohru Takemasa
    Current research in physiology, 2021, 4:202 - 208
  • Denervation-induced muscle atrophy suppression in renalase-deficient mice via increased protein synthesis.
    Katsuyuki Tokinoya; Takanaga Shirai; Yuya Ota; Tohru Takemasa; Kazuhiro Takekoshi
    Physiological reports, Aug. 2020, 8(15):e14475
  • The order of concurrent training affects mTOR signaling but not mitochondrial biogenesis in mouse skeletal muscle.
    Takanaga Shirai; Yuki Aoki; Kohei Takeda; Tohru Takemasa
    Physiological reports, Apr. 2020, 8(7):e14411
■ MISC
  • Effect of acute high-intensity contractions on irisin expression in mouse skeletal muscles and blood
    Sep. 2022, 28(2):17 - 22
  • Effects of mechanistic/mammalian target of rapamycin complex 1 inhibition on mitochondrial dynamics-related responses induced by resistance exercise in mouse skeletal muscle
    Sep. 2022, 28(2):23 - 32
  • The effects of calorie restriction on functional overload-induced muscle hypertrophy in mice
    May 2022, 28(1):7 - 12
  • 代償性過負荷により肥大した骨格筋に対するカロリー制限の影響—Effects of caloric restriction on muscle hypertrophy induced by functional overload
    永瀨 麻梨凜; 白井 隆長; 北岡 祐; 武田 紘平; 武政 徹
    日本運動生理学雑誌 / 日本運動生理学会事務局 [編], Mar. 2021, 28(1):1 - 8, Refereed
  • 運動による新規骨格筋適応メカニズムの解明 : 細胞外マトリックスは制御因子となるか—ELUCIDATION OF NOVEL SKELETAL MUSCLE ADAPTATION MECHANISM BY EXERCISE : DOES EXTRACELLULAR MATRIX REGULATE SKELETAL MUSCLE ADAPTATION
    武政 徹; 白井 隆長
    若手研究者のための健康科学研究助成成果報告書 = Research-aid report, Apr. 2020, 35:73 - 79
■ Affiliated academic society
  • European College of Sport Science
  • 日本体力医学会
  • 日本運動生理学会
■ Research Themes
  • 加齢に伴う骨格筋ミトコンドリア機能低下に対する運動効果のレナラーゼ分子機構の解明
    日本学術振興会, 科学研究費助成事業, 基盤研究(B)
    横浜国立大学
    01 Apr. 2026 - 31 Mar. 2030
  • エクサカインの分泌動態を指標とした新規運動処方の開発
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists
    Kanagawa University
    01 Apr. 2025 - 31 Mar. 2028
  • エクサカインに着目したサルコペニア改善療法の開発
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for JSPS Fellows
    Kanagawa University
    25 Apr. 2023 - 31 Mar. 2026
  • エクサカインがもたらす個体機能改善メカニズムの解明とその応用
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
    University of Tsukuba
    01 Apr. 2023 - 31 Mar. 2026
  • 運動様式特異的なエクサカインの機能解明とその応用
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists
    01 Apr. 2022 - 31 Mar. 2025
  • 中冨健康科学振興財団「研究助成金」
    公益財団法人 中冨健康科学振興財団
    2022 - 2023
  • 骨格筋の質的可塑性を制御する細胞外マトリックスの役割
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for JSPS Fellows
    University of Tsukuba
    24 Apr. 2020 - 31 Mar. 2022
  • YMFSスポーツチャレンジ助成 第14期生
    公益財団法人 ヤマハ発動機スポーツ振興財団
    2020 - 2021
  • 第35回若手研究者のための健康科学研究助成(一般課題)
    公益財団法人 明治安田厚生事業団
    2018 - 2019
■ Industrial Property Rights
  • 特開2024-022770, 特願2022-126100, 慢性腎臓病の予防、改善又は治療用組成物
    宮崎 均, 武政 徹, 遠藤 朱莉, 白井 隆長
  • 特許第7371851号, 特開2021-013326, 特願2019-129760, 肉体的疲労及び疲労感を予防又は改善するオレアナン型トリテルペンを含有する組成物
    鈴木 啓人, 山内 優輝, 武政 徹, 高木 英樹, 前田 清司, 妙▲圓▼園 香苗, 白井 隆長, 川合 英介