Translationally controlled tumor protein interacts with connexin 43 and facilitates intercellular coupling between cardiomyocytes
Yaopeng Hu; Wenqian Cai; Yuko Hidaka; Keizo Hiraishi; Jiehui Cang; Masanari Umemura; Utako Yokoyama; Björn C. Knollmann; Yoshihiro Ishikawa; Takayuki Fujita
Frontiers in Cell and Developmental Biology, 20 Mar. 2025, 13, Refereed

Resistance exercise has an antihypertensive effect comparable to that of aerobic exercise in hypertensive patients: a meta-analysis of randomized controlled trials
Hidetaka Morita; Makiko Abe; Yasunori Suematsu; Yoshinari Uehara; Rie Koyoshi; Kanta Fujimi; Akihito Ideishi; Kohei Takata; Yuta Kato; Tetsuo Hirata; Eiji Yahiro; Natsumi Morito; Ken Kitajima; Atsushi Satoh; Chikara Yoshimura; Shintaro Ishida; Shota Okutsu; Koji Takahashi; Yukiko Shinohara; Takashi Sakaguchi; Shiori Katsuki; Kazuhiro Tada; Takako Fujii; Shunsuke Funakoshi; Yaopeng Hu; Tomonori Satoh; Hirofumi Ohnishi; Keisuke Okamura; Hiroyuki Mizuno; Kimika Arakawa; Kei Asayama; Toshio Ohtsubo; Tomoaki Ishigami; Shigeru Shibata; Takayuki Fujita; Masanori Munakata; Mitsuru Ohishi; Atsuhiro Ichihara; Tomohiro Katsuya; Masashi Mukoyama; Hiromi Rakugi; Koichi Node; Hisatomi Arima; Shin-ichiro Miura
Hypertension Research, 28 Nov. 2024, 48(2):733 - 743, Refereed

Differences in the effects of exercise on blood pressure depending on the physical condition of the subject and the type of exercise: a systematic review and meta-analysis
Yasunori Suematsu; Hidetaka Morita; Makiko Abe; Yoshinari Uehara; Rie Koyoshi; Kanta Fujimi; Akihito Ideishi; Kohei Takata; Yuta Kato; Tetsuo Hirata; Eiji Yahiro; Natsumi Morito; Ken Kitajima; Yuiko Yano; Atsushi Satoh; Chikara Yoshimura; Shintaro Ishida; Shota Okutsu; Koji Takahashi; Yukiko Shinohara; Takashi Sakaguchi; Shiori Katsuki; Kazuhiro Tada; Takako Fujii; Shunsuke Funakoshi; Yaopeng Hu; Tomonori Satoh; Hirofumi Ohnishi; Keisuke Okamura; Hiroyuki Mizuno; Kimika Arakawa; Kei Asayama; Toshio Ohtsubo; Tomoaki Ishigami; Shigeru Shibata; Takayuki Fujita; Masanori Munakata; Mitsuru Ohishi; Atsuhiro Ichihara; Tomohiro Katsuya; Masashi Mukoyama; Hiromi Rakugi; Koichi Node; Hisatomi Arima; Shin-ichiro Miura
Hypertension Research, 01 Nov. 2024, 48(2):720 - 732, Refereed

Long-Term Tracking of the Effects of Colostrum-Derived Lacticaseibacillus rhamnosus Probio-M9 on Gut Microbiota in Mice with Colitis-Associated Tumorigenesis.
Feiyan Zhao; Keizo Hiraishi; Xiaodong Li; Yaopeng Hu; Daibo Kojima; Zhihong Sun; Heping Zhang; Lin-Hai Kurahara
Biomedicines, 27 Feb. 2024, 12(3), Refereed

The Role of TRPM4 in Cardiac Electrophysiology and Arrhythmogenesis
Yaopeng Hu; Jiehui Cang; Keizo Hiraishi; Takayuki Fujita; Ryuji Inoue
International Journal of Molecular Sciences, 22 Jul. 2023, 24(14):11798 - 11798, Refereed

Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension.
Keizo Hiraishi; Lin Hai Kurahara; Kaori Ishikawa; Tetsuhiko Go; Naoya Yokota; Yaopeng Hu; Takayuki Fujita; Ryuji Inoue; Katsuya Hirano
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2022, 58:50 - 62, Refereed

Theoretical Investigation of the Mechanism by which A Gain-of-Function Mutation of the TRPM4 Channel Causes Conduction Block
Yaopeng Hu; Qin Li; Yanghua Shen; Takayuki Fujita; Xin Zhu; Ryuji Inoue
International Journal of Molecular Sciences, 07 Aug. 2021, 22(16):8513, Refereed

An Arrhythmic Mutation E7K Facilitates TRPM4 Channel Activation via Enhanced PIP2 Interaction
Yaopeng Hu; Qin Li; Lin-Hai Kurahara; Narumi Shioi; Keizo Hiraishi; Takayuki Fujita; Xin Zhu; Ryuji Inoue
Cells, 22 Apr. 2021, 10(5):983, Refereed

Inhibitory Effects of Breast Milk-Derived Lactobacillus rhamnosus Probio-M9 on Colitis-Associated Carcinogenesis by Restoration of the Gut Microbiota in a Mouse Model
Haiyan Xu; Keizo Hiraishi; Lin-Hai Kurahara; Yuko Nakano-Narusawa; Xiaodong Li; Yaopeng Hu; Yoko Matsuda; Heping Zhang; Katsuya Hirano
Nutrients, 30 Mar. 2021, 13(4):1143, Refereed

Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation.
Yaopeng Hu; Daniela Ross Kaschitza; Maria Essers; Prakash Arullampalam; Takayuki Fujita; Hugues Abriel; Ryuji Inoue
Pflugers Archiv : European journal of physiology, 04 Jan. 2021, Refereed

過剰なTRPM4チャネルの活性が伝導速度とAP形状に変化を及ぼす可能性の検討 コンピュータシミュレーション研究(Excessive TRPM4 channel activity may change conduction velocities and AP shapes: a computer simulation study)
李 欽; 朱 欣; 胡 耀鵬; 沈 文楓; 井上 隆司
心電図, Feb. 2020, 40(Suppl.2):S - 52

TRPM4チャネルと心血管の生理・病態生理
井上隆司; 胡耀鵬; 沼田朋大
医学のあゆみ, 07 Sep. 2019, 270(10):954 - 960

徐脈性不整脈遺伝子変異TRPM4-E7Kチャネルの数理モデルシミュレーション
胡 耀鵬; 平石 敬三; 倉原 琳; 沼田 朋大; 井上 隆司
日本生理学雑誌, Feb. 2019, 81(1):4 - 4

Daikenchuto (DaJianZhongTang) ameliorates intestinal fibrosis by activating myofibroblast TRPA1 channel
Keizo Hiraishi; Lin-Hai Kurahara; Miho Sumiyoshi; Yao-Peng Hu; Kaori Koga; Miki Onitsuka; Daibo Kojima; Lixia Yue; Hidetoshi Takedatsu; Yu-Wen Jian; Ryuji Inoue
World Journal of Gastroenterology, 21 Sep. 2018, 24(35):4036 - 4053, Refereed

TRPM7‐mediated spontaneous Ca2+ entry regulates the proliferation and differentiation of human leukemia cell line K562
Kiriko Takahashi; Chisato Umebayashi; Tomohiro Numata; Akira Honda; Jun Ichikawa; Yaopeng Hu; Ken Yamaura; Ryuji Inoue
Physiological Reports, 23 Jul. 2018, 6(14):e13796, Refereed

Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease
Lin Hai Kurahara; Keizo Hiraishi; Yaopeng Hu; Kaori Koga; Miki Onitsuka; Mayumi Doi; Kunihiko Aoyagi; Hidetoshi Takedatsu; Daibo Kojima; Yoshitaka Fujihara; Yuwen Jian; Ryuji Inoue
Cellular and Molecular Gastroenterology and Hepatology, 08 Feb. 2018, 5(3):299 - 318, Refereed

Uncovering the arrhythmogenic potential of TRPM4 activation in atrial-derived HL-1 cells using novel recording and numerical approaches
Yaopeng Hu; Yubin Duan; Ayako Takeuchi; Lin Hai-Kurahara; Jun Ichikawa; Keizo Hiraishi; Tomohiro Numata; Hiroki Ohara; Gentaro Iribe; Michio Nakaya; Masayuki X. Mori; Satoshi Matsuoka; Genshan Ma; Ryuji Inoue
CARDIOVASCULAR RESEARCH, Aug. 2017, 113(10):1243 - 1255, Refereed

共培養系を用いた線維芽細胞による心房興奮伝播制御機構の検討
胡 耀鵬; 平石 敬三; 倉原 琳; 市川 純; 沼田 朋大; 井上 隆司
日本生理学雑誌, Feb. 2017, 79(1):28 - 28

アンギオテンシン(AG)II処置によるBa誘発性心筋細胞異常興奮亢進の分子機構
胡 耀鵬; 朱 欣; 井上 隆司
日本生理学雑誌, Mar. 2016, 78(2):36 - 36

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds
Seishiro Sawamura; Masahiko Hatano; Yoshinori Takada; Kyosuke Hino; Tetsuya Kawamura; Jun Tanikawa; Hiroshi Nakagawa; Hideharu Hase; Akito Nakao; Mitsuru Hirano; Rachapun Rotrattanadumrong; Shigeki Kiyonaka; Masayuki X. Mori; Motohiro Nishida; Yaopeng Hu; Ryuji Inoue; Ryu Nagata; Yasuo Mori
MOLECULAR PHARMACOLOGY, Mar. 2016, 89(3):348 - 363, Refereed

Significant contribution of TRPC6 channelmediated Ca2+ influx to the pathogenesis of Crohn's disease fibrotic stenosis
Lin Hai Kurahara; Keizo Hiraishi; Miho Sumiyoshi; Mayumi Doi; Yaopeng Hu; Kunihiko Aoyagi; Yuwen Jian; Ryuji Inoue
Journal of Smooth Muscle Research, 2016, 52(1):78 - 92, Refereed

Intestinal Myofibroblast TRPC6 Channel May Contribute to Stenotic Fibrosis in Crohn's Disease
Lin Hai Kurahara; Miho Sumiyoshi; Kunihiko Aoyagi; Keizo Hiraishi; Kyoko Nakajima; Midori Nakagawa; Yaopeng Hu; Ryuji Inoue
INFLAMMATORY BOWEL DISEASES, Mar. 2015, 21(3):496 - 506, Refereed

TRPチャネルを介した心不整脈発生機序
井上隆司; 胡耀鵬
実験医学, Feb. 2014, 32(4):534 - 539, Refereed

Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin dependent kinase Ⅱ
Juan Shi; Naomi Geshi; Shinichi Takahashi; Shigeki Kiyonaka; Jun Ichikawa; Yaopeng Hu; Yasuo Mori; Yushi Ito; Ryuji Inoue
JOURNAL OF PHYSIOLOGY-LONDON, Jun. 2013, 591(11):2851 - 2866, Refereed

Lipid-mediated mechanisms involved in the mechanical activation of TRPC6 and TRPV4 channels in the vascular tone regulation
Ryuji Inoue; Yaopeng Hu; Yubin Duan; Kyohei Itsuki
Mechanically Gated Channels and their Regulation, 01 Jan. 2012, :281 - 301, Refereed

Efficiently tracking of stem cells in vivo using different kinds of superparamagnetic iron oxide in swine with myocardial infarction
Ma Gen-shan; Qi Chun-mei; Liu Nai-feng; Shen Cheng-xing; Chen Zhong; Liu Xiao-jun; Hu Yao-peng; Zhang Xiao-li; Teng Gao-jun; Ju Sheng-hong; Ma Ming; Tang Yao-liang
CHINESE MEDICAL JOURNAL, Apr. 2011, 124(8):1199 - 1204, Refereed

Identification and differentiation of magnetically labeled mesenchymal stem cells in vivo in swines with myocardial infarction
Chun-mei Qi; Gen-shan Ma; Nai-feng Liu; Cheng-xing Shen; Zhong Chen; Xiao-jun Liu; Yao-peng Hu; Xiao-li Zhang; Ji-yuan Chen; Sheng-hong Ju; Yao-liang Tang
INTERNATIONAL JOURNAL OF CARDIOLOGY, Jan. 2009, 131(3):417 - 419, Refereed

Transplantation of magnetically labeled mesenchymal stem cells improves cardiac function in a swine myocardial infarction model
QI Chun-mei; MA Gen-shan; LIU Nai-feng; SHEN Cheng-xing; CHEN Zhong; LIU Xiao-jun; HU Yao-peng; ZHANG Xiao-li; TENG Gao-jun; JU Sheng-hong; MA Ming; TANG Yao-liang
Chinese Medical Journal, Jan. 2008, 121(6):544 - 550, Refereed

TRPM4チャネルと心血管の生理・病態生理—Physiological and pathophysiological significance of cardiovascular TRPM4 channels inferred from atomic structure and numerical simulation—第1土曜特集 TRPチャネルのすべて ; TRPMチャネル
井上 隆司; 胡 耀鵬; 沼田 朋大
医学のあゆみ, 07 Sep. 2019, 270(10):954 - 959

SPECIFICITY OF ENDOGENOUS INHIBITOR FOR THE SNAKE NEUROTOXIN TRIFLIN: INTERACTION AND STRUCTURE ANALYSIS
Narumi Shioi; Takashi Tadokoro; Yaopeng Hu; Lin Hai Kurahara; Keizo Hiraishi; Katsumi Maenaka; Isao Kuraoka; Shigeyuki Terada
TOXICON, Feb. 2019, 158:S34 - S34

徐脈性不整脈遺伝子変異TRPM4-E7Kチャネルの数理モデルシミュレーション
胡耀鵬; 平石敬三; 倉原琳; 沼田朋大; 井上隆司
日本生理学雑誌(Web), 2019, 81(1)

共培養系を用いた線維芽細胞による心房興奮伝播制御機構の検討
胡耀鵬; 平石敬三; 倉原琳; 市川純; 沼田朋大; 井上隆司
日本生理学雑誌(Web), 2017, 79(1)

Post-translational mechanisms for cardiovascular TRPC6 channel regulation and their physiological/pathophysiological implications.
Ryuji Inoue; Jun Ichikawa; Lin Kurahara; Hu Yaopeng; Akira Honda
JOURNAL OF VASCULAR RESEARCH, 2014, 51:7 - 7

Altered PIP2 sensitivity may underlie the arrhythmogenicity of mutant TRPM4 channel
Ryuji Inoue; Yaopeng Hu; Yasushi Okamura; Masayuki Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124:59P - 59P

The pathophysiological implications of TRP channels in cardiac arrhythmia
Ryuji Inoue; Yubin Duan; Yaopeng Hu; Jun Ichikawa, Joint work, Chapter 4
InTech, Feb. 2012
9789535101260

Lipid-mediated mechanisms involved in the mechanical activation of TRPC6 and TRPV4 channels in the vascular tone regulation
Ryuji Inoue; Yaopeng Hu; Yubin Duan; Kyohei Itsuki, Joint work, 281- 300
Springer Verlag, Germany, 2012
9789400750722

TRPM4 チャネルによる不整脈誘発機構の統合的な検討
胡耀鵬; 平石敬三; 倉傑輝; 李欽, 朱欣; 井上隆司; 藤田孝之
第101回日本生理学会, 30 Mar. 2024

プルキンエ線維におけるTRPM4チャネルの機能亢進型変異による、不整脈誘発機構の解明
胡耀鵬; 平石敬三; 倉傑輝; 李欽, 朱欣; 井上隆司; 藤田孝之
第74回西日本生理学会, 21 Oct. 2023

TRPM4チャネル変異体による不整脈誘発機構の検討：実験と数理モデルに基づいたアプローチ
胡耀鵬; 李欽; 沈揚華; 藤田孝之; 朱欣; 井上隆司
第13回トランスポーター研究会九州部会シンポジウム II, 05 Aug. 2023

機能亢進型 TRPM4チャネル変異体による不整脈誘発機構の検討
胡耀鵬; 李欽; 藤田孝之; 朱欣; 井上隆司
第100回日本生理学会, 14 Mar. 2023

実験と数理モデルに基づいた TRPM4チャネル変異体の徐脈性不整脈誘発機構の検討
胡 耀鵬; 李 欽; 沈 掦華; 藤田 孝之; 朱 欣; 井上 隆司
第99回日本生理学会大会, 18 Mar. 2022

CaMKIIを介したTRPM4チャンネル過剰活性化の催不整脈の理論的考察
胡 耀鵬; Kaschitza; Daniela Ross; Essers, Maria; Arullampalam Prakash; 崔 媛媛; Abriel, Hugues; 井上 隆司
第97回 日本生理学会大会, 19 Mar. 2020

Quantitative evaluation of the role of CaMKII-mediated TRPM4 regulation in arrhythmogenicity
Yaopeng Hu; Daniela Ross Kaschitza; Maria Essers; Prakash Arullampalam; Yuanyuan Cui; Hugues Abriel; Ryuji Inoue
第70回 西日本生理学会, 01 Nov. 2019

Investigation of CaMKII-mediated TRPM4 regulation in arrhythmogenicity
Hu, Yaopeng; Kaschitza; Daniela Ross; Essers, Maria; Inoue, Ryuji; Abriel, Hugues
11th International BioMedical Transporters Conference, 07 Aug. 2019

徐脈性不整遺伝子変異 TRPM4 -E7K チャネルの数理モデシミュレーョン
胡 耀鵬; 平石敬三; 倉原 琳; 沼田朋大; 井上隆司
第 69 回西日本生理学会, 05 Oct. 2018

Multi-hierarchical analysis of TRPM4 arrhythmogenicity by experimental and numerical approaches
Hu Yaopeng; Shen Yanghua; Hiraishi Keizo; Kurahara Lin Hai; Ichikawa Jun; Numata Tomohiro; Qiu Feng; Shen Wenfeng; Zhu Xin; Inoue Ryuji
The 95st Annual Meeting of the Physiology Society of Japan, 30 Mar. 2018

Numerical Model-Based Investigation on the Role of Transient Receptor Potential Melastatin Subfamily Member 4 (TRPM4) Channel in Cardiac Arrhythmogenicity
Yaopeng Hu; Keizo Hiraishi; Lin-Hai Kurahara; Jun Ichikawa; Tomohiro Numata; Xin Zhu; Ryuji Inoue
39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 15 Jul. 2017

TRPM4 channel and its significant implications in arrhythmogenicity
Yaopeng Hu; Yanghua Shen; Keizo Hiraishi; Lin-Hai Kurahara; Jun Ichikawa; Tomohiro Numata; Feng Qiu; Wenfeng Shen; Xin Zhu; Ryuji Inoue
第32回 心電情報処理ワークショップ, 10 Jun. 2017

An arrhythmic mutation modifies TRPM4 channel gating via altered PIP2 sensitivity
Hu Y; Kurahara LH; Shioi N; Hiraishi K; Ichikawa J; Numata T; Okamura Y; Inoue R
The 93rd Annual Meeting of the Physiological Society of Japan, 24 Mar. 2016

アンギオテンシン（AG）II 処置によるBa 誘発性心 筋細胞異常興奮亢進の分子機構
胡耀鵬,朱欣; 井上隆司
第66回 西日本生理学会, 10 Oct. 2015

Does activation of TRPM4 contribute to the pathophysiological automaticity of HL-1 atrial cardiomyocyte model?
Yaopeng Hu; Ryuji Inoue; Xin Zhu; Tomohiro Numata
NIPS International Workshop TRPs and SOCs ~Unconventional Ca2+ Physiology~, 04 Jun. 2015, Masayuki X. Mori (Kyoto University) and Motohiro Nishida (NIPS)

不整脈型変異E7Kが引き起こすTRPM4チャネルのPIP2感受性変化と活性亢進機構
胡 耀鵬; 岡村 康司; 森 誠之; 井上 隆司
第24回日本循環薬理学会, 05 Dec. 2014

催不整脈性変異によるTRPM4 チャネルPIP2 感受性変化の動力学的解析
胡 耀鵬; 倉原 琳; 市川 純; 岡村康司; 森 誠 之; 井上隆司
第65回西日本生理学会, 23 Oct. 2014

Mutagenic and post-translational modifications of the mechanosensitivity of reno-cardiovascular TRPC6 channel
Inoue, R; Jian, Z; Ichikwa, J; Nakagawa, M; Kurahara, L; Hu Y
The 2nd International Symposium of Mechanobiology, 22 May 2014

Altered PIP2 sensitivity may underlie the arrhythmogenicity of mutant TRPM4 channel
Inoue R., Hu Y; Okamura Y; Mori M
第87回日本薬理学会年会JPS シンポジウム, 21 Mar. 2014

Reno-pathogenic mutations and PKG-mediated phosphorylation alter TRPC6 mechanosensitivity.
Inoue R; Ichikawa J; Nakagawa M; Kurahara R; Hu Y
KPS-PSJ symposium (FAOPS Joint Symposium), 18 Mar. 2014

Enhanced PIP2 sensitivity of human TRPM4 channel with an arrhythmic mutation
Hu Yaopeng; Kurahara Rin; Okamura Yasushi; Mori Masayuki; Inoue Ryuji
第91回日本生理学会大会, 17 Mar. 2014

心リモデリング時に発現増加するTRPM4チャネルの催不整脈の定量的の検討
胡耀鵬; 段玉斌; 倉原琳; 市川純; 井上隆司
第23回日本循環薬理学会, 06 Dec. 2013

PIP2によるTRPM4チャネルの制御機構―催不整脈性異体を手がかりとした解析
胡耀鵬; 岡村康司; 森誠之; 井上隆司
2013「心血管輸送分子の構造・機能・病態の統合的研究戦略」(生理研研究会), 27 Nov. 2013

催不整脈性遺伝子変異によるTRPM4チャネルPIP2感受性の変化
胡耀鵬; 岡村康司; 森誠之; 井上隆司
第64回西日本生理学会, 19 Oct. 2013

Arrhythmogenic significance of TRPM4 channel evaluated by a new experimental approach
Ryuji Inoue; Yaopeng Hu; Yubin Duan; Lin Hai; Jun Ichikawa
International Conference of Physiological Sciences, 02 Nov. 2012

TRPM4チャネル発現増加による不整脈誘発機構の検討
胡耀鵬; 段玉斌; 倉原琳; 市川純; 井上隆司
第63回西日本生理学会, 19 Oct. 2012

TRPM4チャネルの催不整脈性の再検討
胡耀鵬; 段玉斌; 市川純; 倉原琳; 井上隆司
第8回TRPチャネル研究会（生理研研究会）, 14 Jun. 2012

Investigation on the arrhythmogenecity of Nav1.5-TRPM4 channel complex
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists
Fukuoka University
Apr. 2020 - Mar. 2023

Quantitative investigation of CaMKII-mediated TRPM4 regulation in atrial remodeling-associated arrhythmias
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B)
Fukuoka University
Apr. 2017 - Mar. 2020