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Last Updated :2025/04/30

Naoto Shirasu

School of Medicine
Lecturer/Senior Assistant Professor

Researcher information

■ Degree
  • 博士(理学), 九州大学
■ Research Keyword
  • chimeric T-cell antigen receptor
  • gene therapy
  • cancer stem cell
  • human antibody
  • exosome
  • photoimmunotherapy
■ Field Of Study
  • Life sciences, Immunology, Immunology
  • Life sciences, Cell biology, Cell Biology
  • Life sciences, Molecular biology, Molecular Biology

Career

■ Career
  • 2011
    福岡大学医学部医学科生化学・講師
  • 2008 - 2009
    九州大学システム情報科学研究院電子デバイス工学部門・NEDO学術研究員
  • 2009
    福岡大学医学部医学科生化学・助教
  • 2007 - 2008
    株式会社IBC・プロジェクトマネージャ
  • 2005 - 2007
    米国国立衛生研究所・客員研究員
  • 2003 - 2005
    社団法人日本食品衛生協会・リサーチレジデント
■ Educational Background
  • 2000 - 2003
    Kyushu University, 理学研究院, 分子科学専攻

Research activity information

■ Award
  • 13 Dec. 2012
    平成24年度福岡県すこやか健康事業団がん研究助成金優秀賞
  • 18 Sep. 2012
    日本分子腫瘍マーカー研究会, 第32回日本分子腫瘍マーカー研究会学術奨励賞
■ Paper
  • An idea to explore: Determination of single nucleotide polymorphisms in alcohol metabolism-related genes using PCR-based assays to understand the link between an individual's genotype and phenotype
    Naoto Shirasu; Shin'ichiro Yasunaga
    Biochem Mol Biol Educ., 10 Oct. 2023, :Online ahead of print., Refereed
    Lead
  • Acceptance of Murine Islet Allografts Without Immunosuppression in Inguinal Subcutaneous White Adipose Tissue Pretreated With bFGF
    Yuki Nakafusa; Naoyoshi Nitta; Kazunari Ishii; Naoto Shirasu; Takahiro Iwamoto; Takayuki Nemoto; Masafumi Nakamura; Masafumi Goto; Hiroo Iwata; Masaru Taniguchi; Yohichi Yasunami
    Diabetes, 01 Aug. 2022, 71(8):1721 - 1734, Refereed
  • Trophic and immunomodulatory effects of adipose tissue derived stem cells in a preclinical murine model of endometriosis.
    Toyofumi Hirakawa; Fusanori Yotsumoto; Naoto Shirasu; Chihiro Kiyoshima; Daichi Urushiyama; Kenichi Yoshikawa; Kohei Miyata; Masamitsu Kurakazu; Kaori Azuma Koga; Mikiko Aoki; Kazuki Nabeshima; Kaori S Koga; Yutaka Osuga; Hiroaki Komatsu; Fuminori Taniguchi; Tasuku Harada; Shin'ichiro Yasunaga; Shingo Miyamoto
    Scientific reports, 16 May 2022, 12(1):8031 - 8031, Refereed
  • MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis.
    Chihiro Kiyoshima; Naoto Shirasu; Daichi Urushiyama; Satoshi Fukagawa; Toyofumi Hirakawa; Kenichi Yoshikawa; Daisuke Izuchi; Kohei Miyata; Masamitsu Kurakazu; Fusanori Yotsumoto; Kenji Hiromatsu; Makoto Nomiyama; Ohta Eiji; Shinichi Hirose; Yoshitoshi Ogura; Tetsuya Hayashi; Kenichiro Hata; Kazuki Nabeshima; Shin'ichiro Yasunaga; Shingo Miyamoto
    Future science OA, 15 Feb. 2021, 7(5):FSO686, Refereed
  • Establishment of human induced pluripotent stem cells derived from skin cells of a patient with Dravet syndrome.
    Yuichi Kimura; Yasuyoshi Tanaka; Naoto Shirasu; Shin'ichiro Yasunaga; Norimichi Higurashi; Shinichi Hirose
    Stem cell research, 15 Jun. 2020, 47:101857 - 101857, Refereed
  • Highly versatile cancer photoimmunotherapy using photosensitizer-conjugated avidin and biotin-conjugated targeting antibodies.
    SHIRASU Naoto; SHIBAGUCHI Hirotomo; YAMADA Hiromi; KUROKI Masahide; YASUNAGA Shin'ichiro
    Cancer Cell Int., 15 Nov. 2019, 19:299, Refereed
    Lead
  • 低線量率放射線被ばくの造血システムに対する放射線障害の解析
    大野芳典; 竹立恭子; 郭芸; 菅野雅元; 白須直人; 安永晋一郎; 大坪素秋; 瀧原義宏
    長崎医学会雑誌, Dec. 2018, 93(特集):334 - 336, Refereed
  • Establishment of a human induced stem cell line (FUi002-A) from Dravet syndrome patient carrying heterozygous R1525X mutation in SCN1A gene.
    Tanaka Y; Higurashi N; Shirasu N; Yasunaga S; Moreira KM; Okano H; Hirose S
    Stem Cell Res., 19 Jun. 2018, 31:11 - 15, Refereed
  • 【放射線生物学と放射線防護を繋ぐ組織反応研究】骨髄の組織反応
    大野 芳典; 竹立 恭子; 白須 直人; 安永 晋一郎; 瀧原 義宏
    放射線生物研究, Dec. 2017, 52(4):336 - 349, Refereed
  • 造血幹細胞の細胞周期と分化の制御におけるGemininの分子機能
    竹立 恭子; 大野 芳典; 山藤 幹茂子; 白須 直人; 大坪 素秋; 安永 晋一郎; 瀧原 義宏
    生命科学系学会合同年次大会, Dec. 2017, 2017年度:[2P - 0772], Refereed
  • Enhancement of antitumor activity by using a fully human gene encoding a single-chain fragmented antibody specific for carcinoembryonic antigen
    Hirotomo Shibaguchi; Naixiang Luo; Naoto Shirasu; Motomu Kuroki; Masahide Kuroki
    ONCOTARGETS AND THERAPY, 2017, 10:3979 - 3990, Refereed
    Lead
  • Duplex PCR-RFLP for the Simultaneous Genotyping of Single Nucleotide Polymorphisms in ADH1B and ALDH2 Genes
    Naoto Shirasu; Shin'ichiro Yasunaga
    ANALYTICAL SCIENCES, Dec. 2016, 32(12):1363 - 1366, Refereed
    Lead
  • Role of Geminin in cell fate determination of hematopoietic stem cells (HSCs).
    Yasunaga S; Ohno Y; Shirasu N; Zhang B; Suzuki-Takedachi K; Ohtsubo M; Takihara Y
    Int. J. Hematol., 15 Jul. 2016, 104(3):324 - 329, Refereed
  • CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5 (carcinoembryonic antigen))
    Shirasu N; Kuroki M
    Atlas Genet. Cytogenet. Oncol. Haematol., 2016, 20(5):243 - 249, Refereed
    Lead
  • Potent and specific antitumor effect of CEA-targeted photoimmunotherapy
    Naoto Shirasu; Hiromi Yamada; Hirotomo Shibaguchi; Motomu Kuroki; Masahide Kuroki
    INTERNATIONAL JOURNAL OF CANCER, Dec. 2014, 135(11):2697 - 2710, Refereed
    Lead
  • Simultaneous Genotyping of Single-nucleotide Polymorphisms in Alcoholism-related Genes Using Duplex and Triplex Allele-specific PCR with Two-step Thermal Cycles
    Naoto Shirasu; Masahide Kuroki
    ANALYTICAL SCIENCES, Nov. 2014, 30(11):1093 - 1096, Refereed
    Lead
  • Novel Treatment Strategies for Cancer and Their Tumor-targeting Approaches Using Antibodies Against Tumor-associated Antigens
    Masahide Kuroki; Naoto Shirasu
    ANTICANCER RESEARCH, Aug. 2014, 34(8):4481 - 4488, Refereed
  • Chimeric antigen receptor(CAR)の遺伝子導入T細胞による腫瘍の治療.
    SHIRASU Naoto; KUROKI Masahide
    臨床免疫・アレルギー科, 2014, 61(6):621 - 626, Refereed
    Lead
  • Tumor-targeted Photodynamic Therapy
    Naoto Shirasu; Sung Ouk Nam; Masahide Kuroki
    ANTICANCER RESEARCH, Jul. 2013, 33(7):2823 - 2831, Refereed
    Lead
  • Possible Therapeutic Targets Among the Molecules Involved in the Warburg Effect in Tumor Cells
    Sung Ouk Nam; Fusanori Yotsumoto; Kohei Miyata; Naoto Shirasu; Shingo Miyamoto; Masahide Kuroki
    ANTICANCER RESEARCH, Jul. 2013, 33(7):2855 - 2860, Refereed
  • Tumor-selective near-infrared-photoimmunotherapy using a human anti-CEA monoclonal antibody
    Shirasu N; Yamada H; Shibaguchi H; Kuroki Mo; Kuroki, Ma
    Mol. Tumor Marker Res., 2013, 28:27 - 28, Refereed
    Lead
  • Functional Design of Chimeric T-Cell Antigen Receptors for Adoptive Immunotherapy of Cancer: Architecture and Outcomes
    Naoto Shirasu; Masahide Kuroki
    ANTICANCER RESEARCH, Jun. 2012, 32(6):2377 - 2383, Refereed
    Lead
  • Biological Response Modifiers Used in Cancer Biotherapy
    Masahide Kuroki; Shingo Miyamoto; Takashi Morisaki; Fusanori Yotsumoto; Naoto Shirasu; Yoshie Taniguchi; Gen-Ichiro Soma
    ANTICANCER RESEARCH, Jun. 2012, 32(6):2229 - 2233, Refereed
  • Cloning of human anti-EpCAM scFv gene and construction of chimeric T-cell antigen receptor specific for EpCAM
    Shirasu N; Yamada H; Shibaguci H; Kuroki Mo; Kuroki Ma
    Mol. Tumor Marker Res., 2012, 27:63 - 64, Refereed
    Lead
  • Molecular Characterization of a Fully Human Chimeric T-Cell Antigen Receptor for Tumor-Associated Antigen EpCAM
    Naoto Shirasu; Hiromi Yamada; Hirotomo Shibaguchi; Motomu Kuroki; Masahide Kuroki
    JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2012, DOI:10.1155/2012/853879, Refereed
    Lead
  • Site-Specific Fluorescent Labeling of VAV by Sortase-Mediated Transpeptidation
    Shirasu N; Houtman JC; Yamaguchi H; Barda-Saad M; Schuck P; Samelson LE
    Peptide Science 2010, 2011, :184, Refereed
    Lead
  • Cloning of human anti-CEA scFv gene and construction of chimeric T-cell antigen receptor specific for CEA
    Shirasu N; Shibaguchi H; Kuroki Mo; Yamada H; Kuroki Ma
    Mol. Tumor Marker Res., 2011, 26:26 - 27, Refereed
    Lead
  • Construction and Molecular Characterization of Human Chimeric T-Cell Antigen Receptors Specific for Carcinoembryonic Antigen
    Naoto Shirasu; Hirotomo Shibaguci; Motomu Kuroki; Hiromi Yamada; Masahide Kuroki
    ANTICANCER RESEARCH, Jul. 2010, 30(7):2731 - 2738, Refereed
    Lead
  • Cooperative interactions at the SLP-76 complex are critical for actin polymerization
    Mira Barda-Saad; Naoto Shirasu; Maor H. Pauker; Nirit Hassan; Orly Perl; Andrea Balbo; Hiroshi Yamaguchi; Jon C. D. Houtman; Ettore Appella; Peter Schuck; Lawrence E. Samelson
    EMBO JOURNAL, Jul. 2010, 29(14):2315 - 2328, Refereed
  • Noncompetitive Immunodetection of Benzaldehyde by Open Sandwich ELISA
    Naoto Shirasu; Takeshi Onodera; Kazutaka Nagatomo; Yasuyuki Shimohigashi; Kiyoshi Toko; Kiyoshi Matsumoto
    ANALYTICAL SCIENCES, Sep. 2009, 25(9):1095 - 1100, Refereed
    Lead
  • Differential receptor binding characteristics of consecutive phenylalanines in mu-opioid specific peptide ligand endomorphin-2
    Takeshi Honda; Naoto Shirasu; Kaname Isozaki; Michiaki Kawano; Daiki Shigehiro; Yoshiro Chuman; Tsugumi Fujita; Takeru Nose; Yasuyuki Shimohigashi
    BIOORGANIC & MEDICINAL CHEMISTRY, Jun. 2007, 15(11):3883 - 3888
  • Structural analysis and identification of novel isoforms of the circadian clock gene period in the silk moth Bombyx mori
    Y Takeda; Y Chuman; N Shirasu; S Sato; A Matsushima; A Kaneki; Y Tominaga; Y Shimohigashi; M Shimohigashi
    ZOOLOGICAL SCIENCE, Sep. 2004, 21(9):903 - 915
  • Molecular cogs of the insect circadian clock
    N Shirasu; Y Shimohigashi; Y Tominaga; M Shimohigashi
    ZOOLOGICAL SCIENCE, Aug. 2003, 20(8):947 - 955, Refereed
    Lead
  • Site-directed affinity-labeling of delta opioid receptors by SNpys-containing enkephalin and dynorphin analogues
    K Isozaki; H Fukahori; T Honda; N Shirasu; K Okada; T Nose; K Sakaguchi; Y Shimohigashi
    LETTERS IN PEPTIDE SCIENCE, 2003, 10(5-6):511 - 522, Refereed
  • Specific Affinity Labeling of Delta Opioid Receptors via Thiol-disulfide Exchange Reaction.
    Fukahori H; Shirasu N; Nose T; Sakaguchi K; Costa T; Shimohigashi Y
    Peptide Science 2002, 2003, :357 - 360, Refereed
  • Discriminative disulfide-bonding affinity labeling of opioid receptor subtypes
    N Shirasu; Y Shimohigashi
    JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, Oct. 2001, 49(1-3):587 - 606, Refereed
    Lead
  • Differential Receptor Binding Characteristics of the Phenylalanine Residues at Position 3-4 of Endomorphine 2.
    Honda T; Shigehiro D; Okada K; Shirasu N; Chuman Y; Fujita T; Nose T; Sakaguchi K; Shimohigashi Y
    Peptide Science 2000, 2001, :139 - 142, Refereed
  • The Role of Deltorphin II Phenylalanine Residue in Binding to the δ Opioid Receptor.
    T Honda; N Shirasu; Y Chuman; K Okada; T Fujita; T Nose; Y Shimohigashi
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Nov. 2000, 73(11):2549 - 2552, Refereed
  • Exploration of the role of phenylalanine in the thrombin receptor tethered-ligand peptide by substitution with a series of trifluorophenylalanines
    A Matsushima; T Fujita; K Okada; N Shirasu; T Nose; Y Shimohigashi
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Nov. 2000, 73(11):2531 - 2538, Refereed
  • Synthesis of a Complete Set of L-Difluorophenylalanines, L-(F2)Phe, as Molecular Explorers for the CH/π interaction between Peptide ligand and Receptor.
    T Fujita; T Nose; A Matsushima; K Okada; D Asai; Y Yamauchi; N Shirasu; T Honda; D Shigehiro; Y Shimohigashi
    TETRAHEDRON LETTERS, Feb. 2000, 41(6):923 - 927, Refereed
  • Receptor Interaction Mode of the Phe-phenyl Group of Opioid Peptides.
    Shirasu N; Okada K; Chuman Y; Fujita T; Honda T; Shigehiro D; Nose T; Shimohigashi Y
    Peptide Science 1999, 2000, :25 - 28, Refereed
    Lead
  • Exploration of universal cysteines in the binding sites of three opioid receptor subtypes by disulfide-bonding affinity labeling with chemically activated thiol-containing dynorphin A analogs
    N Shirasu; T Kuromizu; H Nakao; Y Chuman; T Nose; T Costa; Y Shimohigashi
    JOURNAL OF BIOCHEMISTRY, Jul. 1999, 126(1):254 - 259, Refereed
    Lead
  • Affinity Labeling of Opioid Receptor Subtypes by Activated Thiol-containing Dynorphin A Analogs.
    Shirasu N; Kuromizu T; Nakao H; Chuman Y; Nose T; Costa T; Shimohigashi Y
    Peptide Science 1998, 1999, :193 - 196, Refereed
    Lead
■ MISC
  • 低線量率放射線による造血幹細胞の機能低下とその分子機序
    大野 芳典; 竹立 恭子; 郭 芸; 菅野 雅元; 白須 直人; 安永 晋一郎; 大坪 素秋; 瀧原 義宏
    日本放射線影響学会大会講演要旨集, Nov. 2018, 61回:58 - 58
  • 低線量率放射線の造血幹細胞に対する影響(Effect of low dose-rate irradiation on the hematopoietic stem cells)
    大野 芳典; 竹立 恭子; 郭 芸; 菅野 雅元; 白須 直人; 安永 晋一郎; 大坪 素秋; 瀧原 義宏
    臨床血液, Sep. 2018, 59(9):1637 - 1637
  • 低線量放射線被ばくに対する造血システムの分子応答
    大野 芳典; 竹立 恭子; 山藤 幹茂子; 郭 芸; 菅野 雅元; 白須 直人; 安永 晋一郎; 大坪 素秋; 瀧原 義宏
    広島医学, Apr. 2018, 71(4):361 - 363
  • 低線量率放射線が造血に与える影響
    大野 芳典; 竹立 恭子; 山藤 幹茂子; 郭 芸; 菅野 雅元; 白須 直人; 安永 晋一郎; 大坪 素秋; 瀧原 義宏
    生命科学系学会合同年次大会, Dec. 2017, 2017年度:[2P - 0771]
  • 低線量率放射線照射環境下における造血システムへの影響とその分子応答
    大野 芳典; 竹立 恭子; 山藤 幹茂子; 郭 芸; 菅野 雅元; 白須 直人; 安永 晋一郎; 大坪 素秋; 瀧原 義宏
    日本放射線影響学会大会講演要旨集, Oct. 2017, 60回:168 - 168
  • 低線量率被ばくに対する造血幹細胞の分子応答の解析
    大野 芳典; 竹立 恭子; 山藤 幹茂子; 郭 芸; 菅野 雅元; 白須 直人; 安永 晋一郎; 大坪 素秋; 仲 一仁; 瀧原 義宏
    日本放射線影響学会大会講演要旨集, Oct. 2016, 59回:16 - 16
  • Molecular Characterization of a Fully Human Chimeric T-Cell Antigen Receptor for Tumor-Associated Antigen EpCAM (vol 2012, 853879, 2012)
    Naoto Shirasu; Hiromi Yamada; Hirotomo Shibaguchi; Motomu Kuroki; Andmasahide Kuroki
    BIOMED RESEARCH INTERNATIONAL, 2015
  • バイオストレスの分子腫瘍学的解析について
    Kuroki M; Shibaguchi H; Yotsumoto F; Shirasu N
    Support Projects for Upgrading of Education and Research by the Ministry of Education, Culture, Sports, Science and Technology: Support Projects for Upgrading of Education and Research of One Campus Integrated University Type - Annual Report, 2012, 1(1):767 - 770
  • バイオストレスの分子腫瘍学的解析
    Kuroki M; Shibaguchi H; Yotsumoto F; Shirasu N
    Global FUP One Campus Project 6 : Research and Education Center of Control Mechanism for Bio-stress Response, 2010, 2009(1):88 - 92
  • a-helix peptides for bio-panning in the phage display method to obtain the antibodies specific for conformation-change nuclear receptors
    Okada, H; Tokunaga, T; Shirasu N; Matsushima, A; Nose, T; Shimohigashi Y
    Peptide Science 2005, 2006
  • Structural Characteristics of Drosophila Estrogen-Related Receptor Ligand Binding Domain to Capture the Peptide and Non-peptide Ligands
    Liu, X; Matsushima, A; Shirasu, N; Tominaga, Y; Shimohigashi, M; Shimohigashi, Y; Nose, T
    Peptide Science 2004, 2005
  • Triplicate Alternative Splicings that Produce Multiple Variants of the PERIOD Protein in the Silk Moth Bombyx mori by Deletion/Insertion of Peptides
    Takeda, Y; Shirasu, N; Sato, S; Matsushima, A; Chuman, Y; Tominaga, Y; Shimohigashi, M; Shimohigashi, M
    Peptide Science 2004, 2005
  • Two distinctly different isoforms with/without pentapeptide fragment in the silk moth clock protein PERIOD
    Takeda Y; Shirasu N; Sato S; Matasushima A; Chuman Y; Shimohigashi Y
    Peptide Science 2003, 2004, :473 - 476
  • The Mode of Molecular Interation of Phe-3 of Deltorphin II and Endomorphin 2 in Opioid Receptor Binding
    HONDA Takeshi; SHIGEHIRO Daiki; SHIRASU Naoto; CHUMAN Yoshiro; FUJITA Tsugumi; NOSE Takeru; SHIMOHIGASHI Yasuyuki
    Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2000, 1999:429 - 432
■ Books and other publications
  • モデル・コア・カリキュラム対応 医用生化学 ー生体物質の代謝と異常ー 2017年版
    安永 晋一郎; 黒木 政秀; 黒木 求; 瀬川 波子; 衣笠 哲史; 芝口 浩智; 白須 直人; 四元 房典, Editor, 編著
    福岡大学医学部生化学講座, 31 Mar. 2017
    9784990942601
  • モデル・コア・カリキュラム対応 医用生化学 ー生体物質の代謝と異常ー 2016年版
    安永 晋一郎; 黒木 政秀; 黒木 求; 瀬川 波子; 衣笠 哲史; 芝口 浩智; 白須 直人; 四元 房典, Editor, 編著
    福岡大学医学部生化学講座, 31 Mar. 2016
    9784990314699
  • モデル・コア・カリキュラム対応 医用生化学 ー生体物質の代謝と異常ー 2015年版
    安永 晋一郎; 黒木 政秀; 黒木 求; 瀬川 波子; 衣笠 哲史; 芝口 浩智; 白須 直人; 四元 房典, Joint work, 編著
    福岡大学医学部生化学講座, 31 Mar. 2015
    9784990314682
  • モデル・コア・カリキュラム対応 医用生化学―生体物質の代謝と異常― 2014年版
    KUROKI Masahide; KUROKI Motomu; SEGAWA Namiko; SHIBAGUCHI Hirotomo; SHIRASU Naoto; YOTSUMOTO Fusanori, Editor
    福岡大学医学部生化学教室, 2014
    9784990314675
  • モデル・コア・カリキュラム対応 医用生化学―生体物質の代謝と異常― 2013年版
    黒木政秀; 瀬川波子; 芝口浩智; 四元房典; 白須直人, Editor
    福岡大学医学部生化学教室, 2013
    9784990314668
■ Lectures, oral presentations, etc.
  • 光免疫療法の現状とこれから
    白須直人
    第27回日本バイオ治療法学会学術集会, 02 Dec. 2023
  • 飲酒関連遺伝子の一塩基多型を同時に判別する安価で迅速なduplex PCR-RFLP法の開発
    第89回日本生化学会大会, 27 Sep. 2016
  • Integrative and cooperative photoimmunotherapy for cancer using avidin-conjugated near infrared photosensitizer
    第74回日本癌学会学術総会, 09 Oct. 2015
  • Rapid and cost-effective allele-specific PCR for simultaneous genotyping of single nucleotide polymorphisms in alcohol-related genes
    Naoto Shirasu; Masahide Kuroki
    第87回日本生化学会大会, Oct. 2014
  • In vivo antitumor effect of CEA-targeted photoimmunotherapy.
    Naoto Shirasu; Hiromi Yamada; Hirotomo Shibaguchi; Motomu Kuroki; Masahide Kuroki
    第73回日本癌学会学術総会, Sep. 2014
  • CEAを標的とした抗腫瘍光免疫療法.
    SHIRASU Naoto; SHIBAGUCHI Hirotomo; KUROKI Motomu; KUROKI Masahide
    第18回日本がん免疫学会総会, Jul. 2014
  • 担癌マウスモデルにおける近赤外光線免疫療法の抗腫瘍効果.
    白須直人; 山田博美; 芝口浩智; 黒木 求; 黒木政秀
    第17回バイオ治療法研究会学術集会, Dec. 2013
  • Versatile photoimmunotherapy of cancer using avidin-conjugated near infrared photosensitizer and biotinylated antibody.
    Shirasu, N; Yamada, H; Shibaguchi, H; Kuroki, Mo; Kuroki, Ma
    第72回日本癌学会学術総会, Oct. 2013
  • IRDye700結合ヒト抗CEAモノクローナル抗体を用いた消化器癌に対する腫瘍特異的光免疫療法
    白須 直人; 山田 博美; 芝口 浩智; 黒木 求; 黒木 政秀
    第5回福岡県医学会総会, Feb. 2013
  • Photoimmunotherapy using a human anti-CEA monoclonal antibody conjugated with near-infrared photosensitizer.
    Naoto Shirasu; Hiromi Yamada; Hirotomo Shibaguchi; Motomu Kuroki; Masahide Kuroki
    第85回日本生化学会大会, Dec. 2012
  • 近赤外光線感受性物質を融合したヒト抗CEA抗体による癌の光免疫療法
    白須 直人
    平成24年度がん研究助成金贈呈式, Dec. 2012
  • 近赤外光感受性物質IRDye700DXを結合したヒト抗CEA抗体による光免疫療法の検討
    白須 直人; 山田 博美; 芝口 浩智; 黒木 求; 黒木 政秀
    第16回バイオ治療法研究会学術集会, Dec. 2012
  • Targeted photoimmunotherapy of cancer using a near-infrared photosensitizer conjugated with human anti-CEA antibody.
    Naoto Shirasu; Hiromi Yamada; Hirotomo Shibaguchi; Motomu Kuroki; Masahide Kuroki
    第71回日本癌学会学術総会, Sep. 2012
  • ヒト抗CEA抗体を用いた腫瘍選択的な近赤外光免疫療法の検討
    白須 直人; 山田 博美; 芝口 浩智; 黒木 求; 黒木 政秀
    第32回日本分子腫瘍マーカー研究会, Sep. 2012
  • ヒト抗体遺伝子を用いたEpCAM特異的キメラT細胞受容体の構築と機能解析
    白須 直人; 山田 博美; 芝口 浩智; 黒木 求; 黒木 政秀
    第15回バイオ治療法研究会学術集会, Dec. 2011
  • Construction of Human Chimeric T cell antigen receptor Specific for EpCAM.
    Naoto Shirasu; Hiromi Yamada; Hirotomo Shibaguchi; Motomu Kuroki; Masahide Kuroki
    第70回日本癌学会学術総会, Oct. 2011
  • ヒト抗EpCAM単鎖型抗体遺伝子のクローニングとキメラT細胞受容体の作製
    白須 直人; 山田 博美; 芝口 浩智; 黒木 求; 黒木 政秀
    第31回日本分子腫瘍マーカー研究会, Oct. 2011
  • Cooperative Formation of SLP-76-Containing T-Cell Signaling Complex with VAV and Nck
    Naoto Shirasu; Mira Barda-Saad; Hiroshi Yamaguchi; Andrea Balbo; Jon CD Houtman; Ettore Appella; Peter Schuck; Lawrence E Samelson
    第33回日本分子生物学会年会・第83回日本生化学会大会合同大会, Nov. 2010
  • Site-Specific Fluorescent Labeling of VAV by Sortase-Mediated Transpeptidation
    Naoto Shirasu; Jon CD Houtman; Hiroshi Yamaguchi; Mira Barda-Saad; Ettore Appella; Peter Schuck; Lawrence E Samelson
    5th International Peptide Symposium, Nov. 2010
  • Construction and Functional Analysis of Human Chimeric T Cell Antigen Receptors Specific for Carcinoembryonic Antigen
    Naoto Shirasu; Hirotomo Shibaguchi; Motomu Kuroki; Hiromi Yamada; Masahide Kuroki
    第69回日本癌学会学術総会, Sep. 2010
  • CEA特異的なヒト単鎖型抗体遺伝子のクローニングとキメラT細胞受容体の作製
    白須 直人; 芝口 浩智; 黒木 求; 山田 博美; 黒木 政秀
    第30回日本分子腫瘍マーカー研究会, Sep. 2010
■ Affiliated academic society
  • 日本癌学会
  • 日本生化学会
  • 日本ペプチド学会
■ Research Themes
  • 腫瘍細胞と腫瘍浸潤性Tregを同時標的化する光免疫療法による高効率な抗腫瘍免疫賦活化
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
    福岡大学
    Apr. 2023 - Mar. 2026
  • 腫瘍関連抗原と免疫チェックポイント分子CTLA4を同時標的化する光免疫療法の確立
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
    福岡大学
    Apr. 2020 - Mar. 2023
  • 造血幹細胞の増殖・分化制御におけるZFATとGemininの分子的クロストーク
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
    福岡大学
    Apr. 2019 - Mar. 2023
  • がんとその周辺微小環境を包括的に制御する高効率光免疫療法の確立
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
    Fukuoka University
    Apr. 2016 - Mar. 2019
  • 超音波感受性物質内封ナノリポソームを用いた非侵襲的がん超音波力学療法の実用化研究
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C)
    Fukuoka University
    Apr. 2016 - Mar. 2019
  • がんとその周辺微小環境の包括的制御を指向した高汎用性光免疫療法の開発
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B)
    Fukuoka University
    Apr. 2014 - Mar. 2016
  • 光感受性物質IR700を結合したヒト抗腫瘍抗体を用いる近赤外線免疫療法の確立
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C)
    福岡大学
    Apr. 2014 - Mar. 2015
  • 抗体エキソソーム・AbExを用いたDDSの創成と副作用のない癌治療への展開
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B)
    Fukuoka University
    Apr. 2012 - Mar. 2014
  • 概日リズムのペースメーカーホルモンPDH受容体の発現クローニング
    日本学術振興会, 科学研究費助成事業 特別研究員奨励費, 特別研究員奨励費
    九州大学
    2000 - 2002