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Last Updated :2024/12/21



School of Medicine
Lecturer/Senior Assistant Professor

Profile2000.4-2004.3. 細胞内寄生性病原体に対する遺伝子治療・DNAワクチン療法に関する研究に従事 2004.4-2006.9. マラリア原虫に対するワクチン開発に関する研究に従事 2006.10-細胞内寄生性病原体に対する感染防御機構とそのエスケープ機構、およびこれらの基盤に基づく新しいワクチン構築に関する研究に従事

Researcher information

■ Degree
  • 博士(医学), 九州大学
■ Field Of Study
  • Life sciences, Immunology, Immunology
  • Life sciences, Bacteriology, Bacteriology(includes Mycology)
  • Life sciences, Parasitology, Parasitology (includes Sanitary Zoology)

Career

■ Career
  • 01 Oct. 2006
    福岡大学医学部・助手
  • 01 Apr. 2004 - 30 Sep. 2006
    長崎大学熱帯医学研究所・COE研究員
  • 01 Apr. 2002 - 31 Mar. 2004
    日本学術振興会・特別研究員
■ Educational Background
  • Kyushu University, 医学系学府, 病態医学専攻

Research activity information

■ Paper
  • Chlamydia pneumoniae infection-induced endoplasmic reticulum stress causes fatty acid-binding protein 4 secretion in murine adipocytes
    Nirwana Fitriani Walenna; Yusuke Kurihara; Bin Chou; Kazunari Ishii; Toshinori Soejima; Kenji Hiromatsu
    J. Biol. Chem., 28 Feb. 2020, 295(9):2713 - 2723, Refereed
  • Chlamydia trachomatis targets mitochondrial dynamics to promote intracellular survival and proliferation.
    Kurihara Y; Itoh R; Shimizu A; Walenna NF; Chou B; Ishii K; Soejima T; Fujikane A; Hiromatsu K
    Cell Microbiol., 12 Oct. 2018
  • Chlamydia pneumoniae exploits adipocyte lipid chaperone FABP4 to facilitate fat mobilization and intracellular growth in murine adipocytes
    Nirwana Fitriani Walenna; Yusuke Kurihara; Bin Chou; Kazunari Ishii; Toshinori Soejima; Ryota Itoh; Akinori Shimizu; Takeshi Ichinohe; Kenji Hiromatsu
    Biochemical and Biophysical Research Communications, 01 Jan. 2018, 495(1):353 - 359
  • Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus.
    Masui S; Nabeshima S; Ajisaka K; Yamauchi K; Itoh R; Ishii K; Soejima T; Hiromatsu K
    Evid Based Complement Alternat Med., 2017
  • Pancreatic fistulae secondary to trypsinogen activation by Pseudomonas aeruginosa infection after pancreatoduodenectomy
    Kanefumi Yamashita; Takamitsu Sasaki; Ryota Itoh; Daisuke Kato; Naoya Hatano; Toshinori Soejima; Kazunari Ishii; Tadaomi Takenawa; Kenji Hiromatsu; Yuichi Yamashita
    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Jun. 2015, 22(6):454 - 462
  • Chlamydia pneumoniae harness host NLRP3 inflammasome-mediated caspase-1 activation for optimal intracellular growth in murine macrophages
    Ryota Itoh; Issaku Murakami; Bin Chou; Kazunari Ishii; Toshinori Soejima; Toshihiko Suzuki; Kenji Hiromatsu
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2014, 452(3):689 - 694
  • Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models.
    Fujii Y; Kaneko S; Nzou SM; Mwau M; Njenga SM; Tanigawa C; Kimotho J; Mwangi AW; Kiche I; Matsumoto S; Niki M; Osada-Oka M; Ichinose Y; Inoue M; Itoh M; Tachibana H; Ishii K; Tsuboi T; Yoshida LM; Mondal D; Haque R; Hamano S; Changoma M; Hoshi T; Kamo K; Karama M; Miura M; Hirayama K
    PLoS Negl Trop Dis., 31 Jul. 2014, 8(7)
  • Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells
    Emi Sato; Shinichi Imafuku; Kazunari Ishii; Ryota Itoh; Bin Chou; Toshinori Soejima; Juichiro Nakayama; Kenji Hiromatsu
    JOURNAL OF DERMATOLOGICAL SCIENCE, Jun. 2013, 70(3):166 - 172
  • Antiangiogenic Tumor Therapy by DNA Vaccine Inducing Aquaporin-1-Specific CTL Based on Ubiquitin-Proteasome System in Mice
    Bin Chou; Kenji Hiromatsu; Shinji Okano; Kazunari Ishii; Xuefeng Duan; Tohru Sakai; Shigeo Murata; Keiji Tanaka; Kunisuke Himeno
    JOURNAL OF IMMUNOLOGY, Aug. 2012, 189(4):1618 - 1626
  • Topical vitamin D-3 analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions
    E. Sato-Deguchi; S. Imafuku; B. Chou; K. Ishii; K. Hiromatsu; J. Nakayama
    BRITISH JOURNAL OF DERMATOLOGY, Jul. 2012, 167(1):77 - 84
  • ユビキチン化DNA ワクチンによるCD8+ T 細胞の誘導
    石井 一成; 廣松 賢治
    臨床免疫・アレルギー科, 2012, 58(1):105 - 111
  • Human leukocyte antigen class I polymorphisms influence the mild clinical manifestation of Plasmodium falciparum infection in Ghanaian children
    Akiko Yamazaki; Michio Yasunami; Michael Ofori; Hitomi Horie; Mihoko Kikuchi; Gideon Helegbe; Akiko Takaki; Kazunari Ishii; Ahmeddin Hassan Omar; Bartholomew D. Akanmori; Kenji Hirayama
    HUMAN IMMUNOLOGY, Oct. 2011, 72(10):881 - 888, Refereed
  • The involvement of immunoproteasomes in induction of MHC class I-restricted immunity targeting Toxoplasma SAG1
    Ishii K; Hisaeda H; Duan X; Imai T; Sakai T; Fehling HJ; Murata S; Chiba T; Tanaka K; Hamano S; Sano M; Yano A; Himeno K
    Microbes Infect., Apr. 2006, 8(4):1045 - 53, Refereed
  • A novel DNA vaccine based on ubiquitin-proteasome pathway targeting 'self'-antigens expressed in melanoma/melanocyte.
    Zhang M; Obata C; Hisaeda H; Ishii K; Murata S; Chiba T; Tanaka K; Li Y; Furue M; Chou B; Imai T; Duan X; Himeno K
    Gene Ther., Jul. 2005, 12(13):1049 - 57., Refereed
  • WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation.
    Takeda A; Hamano S; Shiraishi H; Yoshimura T; Ogata H; Ishii K; Ishibashi T; Yoshimura A; Yoshida H
    Int Immunol., 2005, 17(7):889 - 97, Refereed
  • Ubiquitin-fusion degradation pathway plays an indispensable role in naked DNA vaccination with a chimeric gene encoding a syngeneic cytotoxic T lymphocyte epitope of melanocyte and green fluorescent protein.
    Zhang M; Ishii K; Hisaeda H; Murata S; Chiba T; Tanaka K; Li Y; Obata C; Furue M; Himeno K
    Immunology, 2004, 112:567 - 74, Refereed
  • Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.
    Onishi K; Li Y; Ishii K; Hisaeda H; Tang L; Duan X; Dainichi T; Maekawa Y; Katunuma N; Himeno K
    Microbes Infect., 2004, 6:468 - 74, Refereed
  • IL-18 gene therapy develops Th1-type immune responses in Leishmania major-infected BALB/c mice: is the effect mediated by the CpG signaling TLR9?
    Li Y; Ishii K; Hisaeda H; Hamano S; Zhang M; Nakanishi K; Yoshimoto T; Hemmi H; Takeda K; AkiraI S; Iwakura Y; Himeno K
    Gene Ther., 2004, 11:941 - 8, Refereed
  • Hyperproduction of Proinflammatory Cytokines by WSX-1-Deficient NKT Cells in Concanavalin A-Induced Hepatitis
    Yamanaka A; Hamano S; Miyazaki Y; Ishii K; Takeda A; Mak TW; Himeno K; Yoshimura A; Yoshida H
    J Immunol., 2004, 172:3590 - 6, Refereed
  • Chemical peeling with salicylic acid in polyethylene glycol vehicle suppresses skin tumour development in hairless mice
    T Dainichi; S Ueda; M Isoda; T Koga; N Kinukawa; Y Nose; K Ishii; S Amano; Horii, I; M Furue
    BRITISH JOURNAL OF DERMATOLOGY, May 2003, 148(5):906 - 912, Refereed
  • WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production.
    Hamano S; Himeno K; Miyazaki Y; Ishii K; Yamanaka A; Takeda A; Zhang M; Hisaeda H; Mak TW; Yoshimura A; Yoshida H
    Immunity, 2003, 19:657 - 67, Refereed
  • Identification of a ubiquitin family protein as a novel neutrophil chemotactic factor.
    Owhashi M; Taoka Y; Ishii K; Nakazawa S; Uemura H; Kambara H
    Biochem Biophys Res Commun., 2003, 309:533 - 9, Refereed
  • Gene gun-based co-immunization of merozoite surface protein-1 cDNA with IL-12 expression plasmid confers protection against lethal Plasmodium yoelii in A/J mice.
    Sakai T; Hisaeda H; Nakano Y; Zhang M; Takashima M; Ishii K; Maekawa Y; Matsumoto S; Nitta Y; Miyazaki J; Yamamoto S; Himeno K
    Vaccine. (2003,:1432-44), 2003, 21:1432 - 44, Refereed
  • A convenient cancer vaccine therapy with in vivo transfer of interleukin 12 expression plasmid using gene gun technology after priming with irradiated carcinoma cells.
    Nishitani MA; Sakai T; Ishii K; Zhang M; Nakano Y; Nitta Y; Miyazaki J; Kanayama HO; Kagawa S; Himeno K
    Cancer Gene Ther., 2002, 9:156 - 63, Refereed
  • Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response.
    Dainichi T; Maekawa Y; Ishii K; Zhang T; Nashed BF; Sakai T; Takashima M; Himeno K
    Infect Immun., 2001, 69:7380 - 6, Refereed
  • Treatment with cathepsin L inhibitor potentiates Th2-type immune response in Leishmania major-infected BALB/c mice.
    Zhang T; Maekawa Y; Sakai T; Nakano Y; Ishii K; Hisaeda H; Dainichi T; Asao T; Katunuma N; Himeno K
    Int Immunol., 2001, 13:975 - 82
  • Splenic cathepsin l is maturated from the proform by interferon-gamma after immunization with exogenous antigens.
    Zhang T; Maekawa Y; Sakai T; Nakano Y; Ishii K; Hisaeda H; Kominami E; Katunuma N; Asao T; Himeno K
    Biochem Biophys Res Commun., 2001, 283:499 - 506
  • Molecular cloning of a cystatin from parasitic intestinal nematode, Nippostrongylus brasiliensis.
    Dainichi T; Maekawa Y; Ishii K; Himeno K
    J Med Invest., 2001, 48:81 - 7, Refereed
  • Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice
    Sakai T; Hisaeda H; Nakano Y; Ishikawa H; Maekawa Y; Ishii K; Nitta Y; Miyazaki J; Himeno K
    Immunology., 2000, 99:615 - 24, Refereed
  • Different cytokines are required for induction and maintenance of the Th2 type response in DBA/2 mice resistant to infection with Leishmania major.
    Nashed BF; Maekawa Y; Takashima M; Zhang T; Ishii K; Dainichi T; Ishikawa H; Sakai T; Hisaeda H; Himeno K
    Microbes Infect., 2000, 2:1435 - 43
  • DNA immunization with Plasmodium falciparum serine repeat antigen: regulation of humoral immune response by coinoculation of cytokine expression plasmid.
    Sakai T; Horii T; Hisaeda H; Zhang M; Ishii K; Nakano Y; Maekawa Y; Izumi K; Nitta Y; Miyazaki J; Himeno K
    Parasitol Int., 1999, 48:27 - 33, Refereed
■ Lectures, oral presentations, etc.
  • 2020年6-8月の福岡大学の病院職員におけるSARS-CoV-2抗体保有状況の報告
    SAKAMOTO Atsuhiko; ITOH Ryota; YOSHIMURA Michinobu; SAKIHARA Eishi; KATO Yoshifumi; HIYOSHI Tetsuya; MASUI Shinta; ISHII Kazunari; HIROMATSU Kenji; NABESHIMA Shigeki
    第21回日本病院総合診療医学会総会, 26 Sep. 2020
■ Affiliated academic society
  • 日本免疫学会
  • 日本寄生虫学会
  • 日本熱帯医学会