Invariant and Diverse NKT Cells Regulate Bacterial Clearance and Pathology in Chlamydial Genital Tract Infection in Mice
Kazunari Ishii; Toshinori Soejima; Yoshiki Ohnishi; Ryo Ozuru; Ryota Itoh; Bin Chou; Michinobu Yoshimura; Akinori Shimizu; Yusuke Kurihara; Atsuhiko Sakamoto; Kenji Hiromatsu
Pathogens, 15 Nov. 2025, 14(11):1166, Refereed
Lead

FABP4-dependent fatty acid oxidation-fueled mitochondrial ROS induces the mobilization of cellular iron and facilitates Trypanosoma cruzi proliferation in murine adipocytes
Kazunari Ishii; Yusuke Kurihara; Michinobu Yoshimura; Nirwana Fitriani Walenna; Akinori Shimizu; Ryo Ozuru; Kenji Hiromatsu
mBio, 08 Oct. 2025, Refereed
Lead

Mitochondrial ROS–ER Stress Axis Governs IL-10 Production in Neutrophils and Regulates Inflammation in Murine Chlamydia pneumoniae Lung Infection
Bin Chou; Kazunari Ishii; Yusuke Kurihara; Akinori Shimizu; Michinobu Yoshimura; Ryo Ozuru; Ryota Itoh; Atsuhiko Sakamoto; Kenji Hiromatsu
Cells, 29 Sep. 2025, Refereed
Lead

Mycobacterium abscessus resides within lipid droplets and acquires a dormancy-like phenotype in adipocytes
Yusuke Kurihara; Akinori Shimizu; Ryo Ozuru; Michinobu Yoshimura; Bin Chou; Ryota Itoh; Kazunari Ishii; Yuko Hirota; Satoshi Takagi; Masaki Fujita; Masahiro Inoue; Kenji Hiromatsu
Biochemical and Biophysical Research Communications, Apr. 2025, Refereed

The appearance of anti-spike receptor binding domain immunoglobulin G4 responses after repetitive immunization with messenger RNA-based COVID-19 vaccines
Michinobu Yoshimura; Atsuhiko Sakamoto; Ryo Ozuru; Yusuke Kurihara; Ryota Itoh; Kazunari Ishii; Akinori Shimizu; Bin Chou; Shigeki Nabeshima; Kenji Hiromatsu
International Journal of Infectious Diseases, Feb. 2024, 139:1 - 5, Refereed

Insufficient anti-spike RBD IgA responses after triple vaccination with intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2
Michinobu Yoshimura; Atsuhiko Sakamoto; Ryo Ozuru; Yusuke Kurihara; Ryota Itoh; Kazunari Ishii; Akinori Shimizu; Bin Chou; Yusuke Sechi; Aya Fujikane; Shigeki Nabeshima; Kenji Hiromatsu
Heliyon, Jan. 2024, Refereed

Chlamydia pneumoniae Lung Infection in Mice Induces Fatty Acid-Binding Protein 4-Dependent White Adipose Tissue Pathology.
Yusuke Kurihara; Nirwana Fitriani Walenna; Kazunari Ishii; Toshinori Soejima; Bin Chou; Michinobu Yoshimura; Ryo Ozuru; Akinori Shimizu; Ryota Itoh; Masato Furuhashi; Gökhan S Hotamisligil; Kenji Hiromatsu
Journal of immunology (Baltimore, Md. : 1950), 15 Apr. 2023, 210(8):1086 - 1097, Refereed

Acceptance of Murine Islet Allografts Without Immunosuppression in Inguinal Subcutaneous White Adipose Tissue Pretreated With bFGF.
Yuki Nakafusa; Naoyoshi Nitta; Kazunari Ishii; Naoto Shirasu; Takahiro Iwamoto; Takayuki Nemoto; Masafumi Nakamura; Masafumi Goto; Hiroo Iwata; Masaru Taniguchi; Yohichi Yasunami
Diabetes, 01 Aug. 2022, 71(8):1721 - 1734, Refereed

Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan.
Atsuhiko Sakamoto; Michinobu Yoshimura; Ryota Itoh; Ryo Ozuru; Kazunari Ishii; Yusuke Sechi; Shigeki Nabeshima; Kenji Hiromatsu
Vaccines, 24 May 2022, 10(6), Refereed

Chlamydia pneumoniae infection-induced endoplasmic reticulum stress causes fatty acid-binding protein 4 secretion in murine adipocytes
Nirwana Fitriani Walenna; Yusuke Kurihara; Bin Chou; Kazunari Ishii; Toshinori Soejima; Kenji Hiromatsu
J. Biol. Chem., 28 Feb. 2020, 295(9):2713 - 2723, Refereed

Chlamydia trachomatis targets mitochondrial dynamics to promote intracellular survival and proliferation.
Kurihara Y; Itoh R; Shimizu A; Walenna NF; Chou B; Ishii K; Soejima T; Fujikane A; Hiromatsu K
Cell Microbiol., 12 Oct. 2018, Refereed

Chlamydia pneumoniae exploits adipocyte lipid chaperone FABP4 to facilitate fat mobilization and intracellular growth in murine adipocytes
Nirwana Fitriani Walenna; Yusuke Kurihara; Bin Chou; Kazunari Ishii; Toshinori Soejima; Ryota Itoh; Akinori Shimizu; Takeshi Ichinohe; Kenji Hiromatsu
Biochemical and Biophysical Research Communications, 01 Jan. 2018, 495(1):353 - 359, Refereed

Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus
Shinta Masui; Shigeki Nabeshima; Kazuhiko Ajisaka; Kei Yamauchi; Ryuta Itoh; Kazunari Ishii; Toshinori Soejima; Kenji Hiromatsu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, Refereed

Pancreatic fistulae secondary to trypsinogen activation by Pseudomonas aeruginosa infection after pancreatoduodenectomy
Kanefumi Yamashita; Takamitsu Sasaki; Ryota Itoh; Daisuke Kato; Naoya Hatano; Toshinori Soejima; Kazunari Ishii; Tadaomi Takenawa; Kenji Hiromatsu; Yuichi Yamashita
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Jun. 2015, 22(6):454 - 462, Refereed

Chlamydia pneumoniae harness host NLRP3 inflammasome-mediated caspase-1 activation for optimal intracellular growth in murine macrophages.
Ryota Itoh; Issaku Murakami; Bin Chou; Kazunari Ishii; Toshinori Soejima; Toshihiko Suzuki; Kenji Hiromatsu
Biochem. Biophys. Res. Commun., Sep. 2014, 452(3):689 - 694, Refereed

Serological Surveillance Development for Tropical Infectious Diseases Using Simultaneous Microsphere-Based Multiplex Assays and Finite Mixture Models
Yoshito Fujii; Satoshi Kaneko; Samson Muuo Nzou; Matilu Mwau; Sammy M. Njenga; Chihiro Tanigawa; James Kimotho; Anne Wanjiru Mwangi; Ibrahim Kiche; Sohkichi Matsumoto; Mamiko Niki; Mayuko Osada-Oka; Yoshio Ichinose; Manabu Inoue; Makoto Itoh; Hiroshi Tachibana; Kazunari Ishii; Takafumi Tsuboi; Lay Myint Yoshida; Dinesh Mondal; Rashidul Haque; Shinjiro Hamano; Mwatasa Changoma; Tomonori Hoshi; Ken-ichi Kamo; Mohamed Karama; Masashi Miura; Kenji Hirayama
PLOS NEGLECTED TROPICAL DISEASES, Jul. 2014, 8(7), Refereed

Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells
Emi Sato; Shinichi Imafuku; Kazunari Ishii; Ryota Itoh; Bin Chou; Toshinori Soejima; Juichiro Nakayama; Kenji Hiromatsu
JOURNAL OF DERMATOLOGICAL SCIENCE, Jun. 2013, 70(3):166 - 172, Refereed

Antiangiogenic Tumor Therapy by DNA Vaccine Inducing Aquaporin-1-Specific CTL Based on Ubiquitin-Proteasome System in Mice
Bin Chou; Kenji Hiromatsu; Shinji Okano; Kazunari Ishii; Xuefeng Duan; Tohru Sakai; Shigeo Murata; Keiji Tanaka; Kunisuke Himeno
JOURNAL OF IMMUNOLOGY, Aug. 2012, 189(4):1618 - 1626, Refereed

Topical vitamin D-3 analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions
E. Sato-Deguchi; S. Imafuku; B. Chou; K. Ishii; K. Hiromatsu; J. Nakayama
BRITISH JOURNAL OF DERMATOLOGY, Jul. 2012, 167(1):77 - 84, Refereed

ユビキチン化DNA ワクチンによるCD8+ T 細胞の誘導
石井 一成; 廣松 賢治
臨床免疫・アレルギー科, 2012, 58(1):105 - 111

Human leukocyte antigen class I polymorphisms influence the mild clinical manifestation of Plasmodium falciparum infection in Ghanaian children
Akiko Yamazaki; Michio Yasunami; Michael Ofori; Hitomi Horie; Mihoko Kikuchi; Gideon Helegbe; Akiko Takaki; Kazunari Ishii; Ahmeddin Hassan Omar; Bartholomew D. Akanmori; Kenji Hirayama
HUMAN IMMUNOLOGY, Oct. 2011, 72(10):881 - 888, Refereed

The involvement of immunoproteasomes in induction of MHC class I-restricted immunity targeting Toxoplasma SAG1
K Ishii; H Hisaeda; XF Duan; T Imai; T Sakai; HJ Fehling; S Murata; T Chiba; K Tanaka; S Hamano; M Sano; A Yano; K Himeno
MICROBES AND INFECTION, Apr. 2006, 8(4):1045 - 1053, Refereed
Lead

A novel DNA vaccine based on ubiquitin-proteasome pathway targeting 'self'-antigens expressed in melanoma/melanocyte
M Zhang; C Obata; H Hisaeda; K Ishii; S Murata; T Chiba; K Tanaka; Y Li; M Furue; B Chou; T Imai; Duan, X; K Himeno
GENE THERAPY, Jul. 2005, 12(13):1049 - 1057, Refereed

WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation
A Takeda; S Hamano; H Shiraishi; T Yoshimura; H Ogata; K Ishii; T Ishibashi; A Yoshimura; H Yoshida
INTERNATIONAL IMMUNOLOGY, Jul. 2005, 17(7):889 - 897, Refereed

Ubiquitin-fusion degradation pathway plays an indispensable role in naked DNA vaccination with a chimeric gene encoding a syngeneic cytotoxic T lymphocyte epitope of melanocyte and green fluorescent protein
MX Zhang; K Ishii; H Hisaeda; S Murata; T Chiba; K Tanaka; Y Li; C Obata; M Furue; K Himeno
IMMUNOLOGY, Aug. 2004, 112(4):567 - 574, Refereed

IL-18 gene therapy develops Th1-type immune responses in Leishmania major-infected BALB/c mice: is the effect mediated by the CpG signaling TLR9?
Y Li; K Ishii; H Hisaeda; S Hamano; M Zhang; K Nakanishi; T Yoshimoto; H Hemmi; K Takeda; S Akira; Y Iwakura; K Himeno
GENE THERAPY, Jun. 2004, 11(11):941 - 948, Refereed

Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection
K Onishi; Y Li; K Ishii; H Hisaeda; LJ Tang; XF Duan; T Dainichi; Y Maekawa; N Katunuma; K Himeno
MICROBES AND INFECTION, Apr. 2004, 6(5):468 - 474, Refereed

Hyperproduction of proinflammatory Cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis
A Yamanaka; S Hamano; Y Miyazaki; K Ishii; A Takeda; TW Mak; K Himeno; A Yoshimura; H Yoshida
JOURNAL OF IMMUNOLOGY, Mar. 2004, 172(6):3590 - 3596, Refereed

WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production
S Hamano; K Himeno; Y Miyazaki; K Ishii; A Yamanaka; A Takeda; M Zhang; H Hisaeda; TW Mak; A Yoshimura; H Yoshida
IMMUNITY, Nov. 2003, 19(5):657 - 667, Refereed

Identification of a ubiquitin family protein as a novel neutrophil chemotactic factor
M Owhashi; Y Taoka; K Ishii; S Nakazawa; H Uemura; H Kambara
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2003, 309(3):533 - 539, Refereed

Chemical peeling with salicylic acid in polyethylene glycol vehicle suppresses skin tumour development in hairless mice
T Dainichi; S Ueda; M Isoda; T Koga; N Kinukawa; Y Nose; K Ishii; S Amano; Horii, I; M Furue
BRITISH JOURNAL OF DERMATOLOGY, May 2003, 148(5):906 - 912, Refereed

Gene gun-based co-immunization of merozoite surface protein-1 cDNA with IL-12 expression plasmid confers protection against lethal Plasmodium yoelii in A/J mice
T Sakai; H Hisaeda; Y Nakano; MX Zhang; M Takashima; K Ishii; Y Maekawa; S Matsumoto; Y Nitta; J Miyazaki; S Yamamoto; K Himeno
VACCINE, Mar. 2003, 21(13-14):1432 - 1444, Refereed

A convenient cancer vaccine therapy with in vivo transfer of interleukin 12 expression plasmid using gene gun technology after priming with irradiated carcinoma cells
M Nishitani; T Sakai; K Ishii; MX Zhang; Y Nakano; Y Nitta; J Miyazaki; H Kanayama; S Kagawa; K Himeno
CANCER GENE THERAPY, Feb. 2002, 9(2):156 - 163, Refereed

Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response
T Dainichi; Y Maekawa; K Ishii; TQ Zhang; BF Nashed; T Sakai; M Takashima; K Himeno
INFECTION AND IMMUNITY, Dec. 2001, 69(12):7380 - 7386, Refereed

Treatment with cathepsin L inhibitor potentiates T(h)2-type immune response in Leishmania major-infected BALB/c mice
T Zhang; Y Maekawa; T Sakai; Y Nakano; K Ishii; H Hisaeda; T Dainichi; T Asao; N Katunuma; K Himeno
INTERNATIONAL IMMUNOLOGY, Aug. 2001, 13(8):975 - 982, Refereed

Selenic cathepsin L is maturated from the proform by interferon-gamma after immunization with exogenous antigens
TQ Zhang; Y Maekawa; T Sakai; Y Nakano; K Ishii; H Hisaeda; E Kominami; N Katunuma; T Asao; K Himeno
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2001, 283(2):499 - 506, Refereed

Molecular cloning of a cystatin from parasitic intestinal nematode, Nippostrongylus brasiliensis.
Dainichi T; Maekawa Y; Ishii K; Himeno K
J Med Invest., 2001, 48(1):81 - 7, Refereed

Different cytokines are required for induction and maintenance of the Th2 type response in DBA/2 mice resistant to infection with Leishmania major
BF Nashed; Y Maekawa; M Takashima; TQ Zhang; K Ishii; T Dainichi; H Ishikawa; T Sakai; H Hisaeda; K Himeno
MICROBES AND INFECTION, Oct. 2000, 2(12):1435 - 1443, Refereed

Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice
T Sakai; H Hisaeda; Y Nakano; H Ishikawa; Y Maekawa; K Ishii; Y Nitta; J Miyazaki; K Himeno
IMMUNOLOGY, Apr. 2000, 99(4):615 - 624, Refereed

DNA immunization with Plasmodium falciparum serine repeat antigen: regulation of humoral immune response by coinoculation of cytokine expression plasmid.
Sakai T; Horii T; Hisaeda H; Zhang M; Ishii K; Nakano Y; Maekawa Y; Izumi K; Nitta Y; Miyazaki J; Himeno K
Parasitol Int., 1999, 48:27 - 33, Refereed

2020年6-8月の福岡大学の病院職員におけるSARS-CoV-2抗体保有状況の報告
SAKAMOTO Atsuhiko; ITOH Ryota; YOSHIMURA Michinobu; SAKIHARA Eishi; KATO Yoshifumi; HIYOSHI Tetsuya; MASUI Shinta; ISHII Kazunari; HIROMATSU Kenji; NABESHIMA Shigeki
第21回日本病院総合診療医学会総会, 26 Sep. 2020

日本臨床寄生虫学会

日本細菌学会

日本免疫学会

日本寄生虫学会

日本熱帯医学会

脂質代謝に着目したトリパノソーマ感染機構・シャーガス病病態形成の分子基盤
日本学術振興会, 科学研究費助成事業, 基盤研究(C)
福岡大学
01 Apr. 2022 - 31 Mar. 2025

クラミジア感染マウスモデルにおけるCD1免疫応答の基礎研究
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
2008 - 2010

CD8陽性T細胞を軸とする新規クラミジアワクチン開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B)
Fukuoka University
2008 - 2009

臍帯血造血幹細胞移植免疫不全マウスを用いたヒトマラリアモデルの作製
日本学術振興会, 科学研究費助成事業, 萌芽研究
長崎大学
2005 - 2006