Menahydroquinone-4 may play a key role in regulating CCL5 expression induced by epidermal growth factor receptor inhibitors
Shotaro Goto; Shuichi Setoguchi; Daisuke Watase; Hirofumi Yamakawa; Ayano Yamada; Mitsuhisa Koga; Koichi Matsuo; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Scientific Reports, 13 Dec. 2023, 13(1)

Cationic Ester Prodrugs of Curcumin with N,N-dimethyl Amino Acid Promoieties Improved Poor Water Solubility and Intestinal Absorption
Mariko Hirano-Kusuda; Shuichi Setoguchi; Mitsuhisa Koga; Shotaro Goto; Ayano Yamada; Daisuke Watase; Nami Nagata-Akaho; Yoshiharu Karube; Kazuhisa Matsunaga; Jiro Takata
Pharmaceutical Research, 20 Apr. 2023, Refereed

Delivery of the reduced form of vitamin K2(20) to NIH/3T3 cells partially protects against rotenone induced cell death
Erina Toki; Shotaro Goto; Shuichi Setoguchi; Kazuki Terada; Daisuke Watase; Hirofumi Yamakawa; Ayano Yamada; Mitsuhisa Koga; Kaori Kubota; Katsunori Iwasaki; Yoshiharu Karube; Kazuhisa Matsunaga; Jiro Takata
Scientific Reports, 18 Nov. 2022, 12(1), Refereed

Cationic N,N-Dimethylglycine Ester Prodrug of 2R-α-Tocotrienol Promotes Intestinal Absorption via Efficient Self-Micellization with Intrinsic Bile Acid Anion.
Watase D; Setoguchi S; Nagata-Akaho N; Goto S; Yamakawa H; Yamada A; Koga M; Karube Y; Matsunaga K; Takata J
Molecules, Apr. 2022, 27(9):2727 - 2727, Refereed

Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K2(20), on All-Trans Retinoic Acid-Resistant HL60 Cell Line.
Hirofumi Yamakawa; Shuichi Setoguchi; Shotaro Goto; Daisuke Watase; Kazuki Terada; Nami Nagata-Akaho; Erina Toki; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Pharmaceutics, 20 May 2021, 13(5), Refereed

Changes in the Penetration Rate of Biosimilar Infliximab Within Japan Using a Japanese Claims Database.
Matsumoto T; Tsuchiya T; Hirano T; Laurent T; Matsunaga K; Takata J
Clinicoecon Outcomes Res., Feb. 2021, 13:145 - 153, Refereed

Ester derivatives of phyllohydroquinone effectively deliver the active form of vitamin K1 topically, owing to their non-photosensitivity.
Shotaro Goto; Shuichi Setoguchi; Nami Nagata-Akaho; Kazuki Terada; Daisuke Watase; Hirofumi Yamakawa; Erina Toki; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 01 Dec. 2020, 155:105519 - 105519, Refereed

Evaluation of photostability and phototoxicity of esterified derivatives of ubiquinol-10 and their application as prodrugs of reduced coenzyme Q10 for topical administration.
Shuichi Setoguchi; Nami Nagata-Akaho; Shotaro Goto; Hirofumi Yamakawa; Daisuke Watase; Kazuki Terada; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
BioFactors (Oxford, England), Nov. 2020, 46(6):983 - 994, Refereed

Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study.
Kazuki Terada; Ayumi Murata; Erina Toki; Shotaro Goto; Hirofumi Yamakawa; Shuichi Setoguchi; Daisuke Watase; Mitsuhisa Koga; Jiro Takata; Kazuhisa Matsunaga; Yoshiharu Karube
Molecules (Basel, Switzerland), 14 Sep. 2020, 25(18), Refereed

Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions.
Shuichi Setoguchi; Ryoji Hidaka; Nami Nagata-Akaho; Daisuke Watase; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Molecules (Basel, Switzerland), 27 Jan. 2020, 25(3), Refereed

Prodrugs for Skin Delivery of Menahydroquinone-4, an Active Form of Vitamin K₂₍₂₀₎, Could Overcome the Photoinstability and Phototoxicity of Vitamin K₂₍₂₀₎.
Goto S; Setoguchi S; Yamakawa H; Watase D; Terada K; Matsunaga K; Karube Y; Takata J
International journal of molecular sciences, May 2019, 20(10):2548 - 2548, Refereed

Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors
Kazuki Terada; Keisuke Migita; Yukari Matsushima; Yumi Sugimoto; Chiaki Kamei; Taichi Matsumoto; Masayoshi Mori; Kazuhisa Matsunaga; Jiro Takata; Yoshiharu Karube
PLOS ONE, 17 Dec. 2018, 13(12):e0209250, Refereed

The Kampo medicine Yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.
Terada K; Matsushima Y; Matsunaga K; Takata J; Karube Y; Ishige A; Chiba K
Bosnian journal of basic medical sciences, Aug. 2018, 18(3):224 - 233, Refereed

Antitumor Effects and Delivery Profiles of Menahydroquinone-4 Prodrugs with Ionic or Nonionic Promoiety to Hepatocellular Carcinoma Cells.
Shuichi Setoguchi; Daisuke Watase; Kazuhisa Matsunaga; Hirofumi Yamakawa; Shotaro Goto; Kazuki Terada; Kenji Ohe; Munechika Enjoji; Yoshiharu Karube; Jiro Takata
Molecules, Jul. 2018, 23(7):1738 - 1738, Refereed

Effect of orally ingested diosgenin into diet on skin collagen content in a low collagen skin mouse model and its mechanism of action
Akinori Haratake; Daisuke Watase; Shuichi Setoguchi; Nami Nagata-Akaho; Kazuhisa Matsunaga; Jiro Takata
LIFE SCIENCES, Apr. 2017, 174:77 - 82, Refereed

Evaluation of pharmacokinetics and the stability of daptomycin in serum at various temperatures
Chika Ogami; Yasuhiro Tsuji; Hidefumi Kasai; Yoichi Hiraki; Yoshihiro Yamamoto; Kazuhisa Matsunaga; Yoshiharu Karube; Hideto To
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Apr. 2017, 57:38 - 43, Refereed

Mechanism Underlying Linezolid-induced Thrombocytopenia in a Chronic Kidney Failure Mouse Model.
Nishijo N; Tsuji Y; Matsunaga K; Kutsukake M; Okazaki F; Fukumori S; Kasai H; Hiraki Y; Sakamaki I; Yamamoto Y; Karube Y; To H
J Pharmacol Pharmacother., Mar. 2017, 8(1):8 - 13, Refereed

The nature of the white opaque substance within colorectal neoplastic epithelium as visualized by magnifying endoscopy with narrow-band imaging.
Endosc Int Open., Nov. 2016, Refereed

【増刊号 消化管拡大内視鏡診断2016】主題研究 拡大内視鏡により視覚化される白色不透明物質
八尾建史; 上尾哲也; 遠城寺宗近; 久部高司; 今村健太郎; 松永和久; 植木敏晴; 田邉寛; 岩下明德
胃と腸, May 2016, 51(5):711 - 726, Refereed

Analysis of renal function during telaprevir-based triple therapy for chronic hepatitis C
Motoyuki Kohjima; Miho Kurokawa; Munechika Enjoji; Tsuyoshi Yoshimoto; Tsukasa Nakamura; Tomoko Ohashi; Kunitaka Fukuizumi; Naohiko Harada; Yusuke Murata; Kazuhisa Matsunaga; Masaki Kato; Kazuhiro Kotoh; Makoto Nakamuta
EXPERIMENTAL AND THERAPEUTIC MEDICINE, May 2016, 11(5):1781 - 1787, Refereed

Intracellular mechanisms underlying lipid accumulation (white opaque substance) in gastric epithelial neoplasms: A pilot study of expression profiles of lipid-metabolism-associated genes
Munechika Enjoji; Motoyuki Kohjima; Kensei Ohtsu; Kazuhisa Matsunaga; Yusuke Murata; Makoto Nakamuta; Kentaro Imamura; Hiroshi Tanabe; Akinori Iwashita; Takashi Nagahama; Kenshi Yao
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Apr. 2016, 31(4):776 - 781, Refereed

Pharmacokinetics of Paradol Analogues Orally Administered to Rats.
Shuichi Setoguchi; Daisuke Watase; Nami Nagata-Akaho; Akinori Haratake; Kazuhisa Matsunaga; Jiro Takata
Journal of agricultural and food chemistry, 09 Mar. 2016, 64(9):1932 - 7, Refereed

Lipid is absorbed in the stomach by epithelial neoplasms (adenomas and early cancers): a novel functional endoscopy technique.
Kensei Ohtsu; Kenshi Yao; Kazuhisa Matsunaga; Takashi Nagahama; Takao Kanemitsu; Yu Matsushima; Motochika Yasaka; Yoichiro Ono; Shoko Fujiwara; Takashi Hisabe; Yasuhiro Takaki; Fumihito Hirai; Toshiyuki Matsui; Teruyo Hanada; Kentaro Imamura; Hiroshi Tanabe; Akinori Iwashita; Toshio Shimokawa
Endoscopy international open, Aug. 2015, 3(4):E318-22, Refereed

Menahydroquinone-4 prodrug: a promising candidate of anti-hepatocellular carcinoma agent
Enjoji M; Watase D; Matsunaga K; Kusuda M; Nagata-Akaho N; Karube Y; Takata J
Diseases, Jul. 2015, 3:150 - 158, Refereed

Effects of oral administration of collagen peptides on skin collagen content and its underlying mechanism using a newly developed low collagen skin mice model
Akinori Haratake; Daisuke Watase; Takuya Fujita; Shuichi Setoguchi; Kazuhisa Matsunaga; Jiro Takata
JOURNAL OF FUNCTIONAL FOODS, Jun. 2015, 16:174 - 182, Refereed

Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma
Shuichi Setoguchi; Daisuke Watase; Kazuhisa Matsunaga; Misa Matsubara; Yohei Kubo; Mariko Kusuda; Nami Nagata-Akaho; Munechika Enjoji; Manabu Nakashima; Morishige Takeshita; Yoshiharu Karube; Jiro Takata
CANCER PREVENTION RESEARCH, Feb. 2015, 8(2):129 - 138, Refereed

Relationship between the Acyl Chain Length of Paradol Analogues and Their Antiobesity Activity following Oral Ingestion
Akinori Haratake; Daisuke Watase; Shuichi Setoguchi; Kazuki Terada; Kazuhisa Matsunaga; Jiro Takata
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Jul. 2014, 62(26):6166 - 6174, Refereed

Orally administered sphingomyelin in bovine milk is incorporated into skin sphingolipids and is involved in the water-holding capacity of hairless mice
Yuko Haruta-Ono; Shuichi Setoguchi; Hiroshi M. Ueno; Satoshi Higurashi; Noriko Ueda; Ken Kato; Tadao Saito; Kazuhisa Matsunaga; Jiro Takata
JOURNAL OF DERMATOLOGICAL SCIENCE, Oct. 2012, 68(1):56 - 62, Refereed

NPC1L1 inhibitor ezetimibe is a reliable therapeutic agent for non-obese patients with nonalcoholic fatty liver disease
Munechika Enjoji; Kazuyuki Machida; Motoyuki Kohjima; Masaki Kato; Kazuhiro Kotoh; Kazuhisa Matsunaga; Manabu Nakashima; Makoto Nakamuta
LIPIDS IN HEALTH AND DISEASE, Mar. 2010, 9:29, Refereed

Preparation and in vivo evaluation of a water-soluble prodrug for 2R-gamma-tocotrienol and as a two-step prodrug for 2,7,8-trimethyl-2S-(beta-carboxyethyl)-6-hydroxychroman (S-gamma-CEHC) in rat
Nami Akaho; Jiro Takata; Takeshi Fukushima; Kazuhisa Matsunaga; Akihiro Hattori; Ryoji Hidaka; Kosuke Fukui; Miyako Yoshida; Toshihiro Fujioka; Yoshiharu Karube; Kazuhiro Imai
DRUG METABOLISM AND DISPOSITION, Sep. 2007, 35(9):1502 - 1510, Refereed

精神科・一般病院グループ実習の試み
KAMIMURA Hidetoshi; MATSUNAGA Kazuhisa; TAKATA Jiro; KARUBE Yoshiharu
Jpn. J. Pharm. Health Care Sci., Oct. 2005, 31(10):851 - 858, Refereed

Technetium labeling of dextran incorporating cysteamine as a ligand
K Matsunaga; K Hara; T Imamura; T Fujioka; J Takata; Y Karube
NUCLEAR MEDICINE AND BIOLOGY, Apr. 2005, 32(3):279 - 285, Refereed
Lead

Antiproliferative constituents from umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica
Miyako Yoshida; Masahiro Fuchigami; Tsuneatsu Nagao; Hikaru Okabe; Kazuhisa Matsunaga; Jiro Takata; Yoshiharu Karube; Ryota Tsuchihashi; Junei Kinjo; Kunihide Mihashi; Toshihiro Fujioka
Biological and Pharmaceutical Bulletin, 2005, 28(1):173 - 175, Refereed

The behavior of dihydropyrazine with DNA strand-breakage activity in vivo
T Yamaguchi; H Nomura; K Matsunaga; S Ito; J Takata; Y Karube
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 2003, 26(11):1523 - 1527, Refereed

Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice
K Mishima; T Tanaka; FL Pu; N Egashira; K Iwasaki; R Hidaka; K Matsunaga; J Takata; Y Karube; M Fujiwara
NEUROSCIENCE LETTERS, Jan. 2003, 337(1):56 - 60

Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC
J Takata; R Hidaka; A Yamasaki; A Hattori; T Fukushima; M Tanabe; K Matsunaga; Y Karube; K Imai
JOURNAL OF LIPID RESEARCH, Dec. 2002, 43(12):2196 - 2204

Delivery systems for antioxidant nutrients
J Takata; K Matsunaga; Y Karube
TOXICOLOGY, Nov. 2002, 180(2):183 - 193, Refereed

Tumor scintigraphy by the method for subtracting the initial image with technetium-99m labeled antibody
Y Karube; K Katsuno; S Ito; K Matsunaga; J Takata; M Kuroki; M Murakami; Y Matsuoka
ANNALS OF NUCLEAR MEDICINE, Dec. 1999, 13(6):407 - 413

Prodrugs for systemic bioreductive activation-independent delivery of phyllohydroquinone, an active form of phylloquinone (Vitamin K-1) 1: Preparation and in vitro evaluation
J Takata; Y Karube; K Matsunaga; M Hanada; R Hidaka; Y Matsushima
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Dec. 1999, 22(12):1347 - 1354, Refereed

Prodrug for bioreductive activation-independent delivery of menaquinone-4 : Human liver enzymatic activation and its action in warfarin-poisoned human liver. (共著)
J Takata; Y Karube; M Hanada; K Matsunaga; H Iwasaki
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 1999, 22(2):172 - 178, Refereed

Inhibition of neuronal dopamine uptake by some antiallergic drugs. (共著)
K Matsunaga; T Sato; H Shuto; Y Tsuruta; K Suemaru; Y Gomita; R Oishi
EUROPEAN JOURNAL OF PHARMACOLOGY, Jun. 1998, 350(2-3):165 - 169, Refereed
Lead

Enhancement of serotonergic neural activity contributes to cyclosporine-induced tremors in mice. (共著)
H Shuto; Y Kataoka; A Kanaya; K Matsunaga; M Sueyasu; R Oishi
EUROPEAN JOURNAL OF PHARMACOLOGY, Jan. 1998, 341(1):33 - 37, Refereed

Potentiation of L-dopa-induced behavioral excitement by histamine H1-receptor antagonists in mice. (共著)
T Sato; K Suemaru; K Matsunaga; S Hamaoka; Y Gomita; R Oishi
JAPANESE JOURNAL OF PHARMACOLOGY, May 1996, 71(1):81 - 84, Refereed

Tumor-specific accumulation of 125I-labeled mouse-human chimeric anti-CEA antibody in a xenografted human cancer model demonstrated by whole-body autoradiography and immunostaining
Masatora Hanmo; Masahide Kuroki; Kazuhisa Matsunaga; Jiro Takata; Yoshiharu Karube; Tarumi Senba; Masaaki Murakami; Fumiko Arakawa; Motohisa Kuwahara; Hiroaki Ozaki; Yuji Matsuoka; Masatoshi Okazaki; Hidetoshi Kanda
Nuclear Medicine and Biology, 1996, 23(6):821 - 826, Refereed

Radioimmunoscintigraphy using technetium-99m-labeled parental mouse and mouse-human chimeric antibodies to carcinoembryonic antigen in athymic nude mice bearing tumor
Yoshiharu Karube; Kentaro Katsuno; Jiro Takata; Kazuhisa Matsunaga; Masatora Haruno; Masahide Kuroki; Fumiko Arakawa; Yuji Matsuoka; Hidetoshi Kanda
Nuclear Medicine and Biology, 1996, 23(6):753 - 759, Refereed

Bioreductive activation-independent delivery of menahydroquinone-4 via prodrug and its action in warfarin-poisoned rat liver. (共著)
Pharm. Sci., 1996, 2:571 - 576, Refereed

Vitamin K prodrugs : 2. Water-soluble prodrugs of menahydroquinone-4 for systemic site-specific delivery. (共著)
J Takata; Y Karube; M Hanada; K Matsunaga; Y Matsushima; T Sendo; R Oishi
PHARMACEUTICAL RESEARCH, Dec. 1995, 12(12):1973 - 1979, Refereed

Vitamin K prodrugs : 1, Synthesis of amino acid esters of menahydroquinone-4 and enzymatic reconversion to an active form. (共著)
J TAKATA; Y KARUBE; M HANADA; K MATSUNAGA; Y MATSUSHIMA; T SENDO; T AOYAMA
PHARMACEUTICAL RESEARCH, Jan. 1995, 12(1):18 - 23, Refereed

Ubiquinol-10エステル誘導体化によるUbiquinol-10及びUbiquinone-10の光不安定性と光毒性の克服及び表皮角化細胞への送達性
山川 博文; 後藤 将太朗; 瀬戸口 修一; 渡瀬 大輔; 寺田 一樹; 土岐 衣梨奈; 古賀 允久; 松永 和久; 加留部 善晴; 高田 二郎
ビタミン, Apr. 2020, 94(4):285 - 285

ロテノン誘発性ミトコンドリア機能障害に対するジプラシドンの効果
村田 亜侑美; 土岐 衣梨奈; 寺田 一樹; 後藤 将太朗; 松永 和久; 山川 博文; 渡瀬 大輔; 瀬戸口 修一; 古賀 允久; 高田 二郎; 加留部 善晴
日本薬学会年会要旨集, Mar. 2020, 140年会:26Q - am100S

Instability of daptomycin in serum at various temperatures may affect its pharmacokinetics
Chika Ogami; Yasuhiro Tsuji; Hidefumi Kasai; Yoshihiro Yamamoto; Kazuhisa Matsunaga; Yoshiharu Karube; Hideto To
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, Nov. 2017, 50:S75 - S76

活性型メナキノン-4の肝細胞がん中への新規送達法による抗がん効果の増強
高田二郎; 瀬戸口修一; 渡瀬大輔; 松永和久; 楠田真理子; 長田(赤穂)菜美; 遠城寺宗近; 中島学; 竹下盛重; 加留部善晴
Research, 15 Jun. 2016, 21(2):23 - 27

Antiproliferative Constituents from Umbelliferae Plants.Ⅸ.New Triterpenoid Glycosides from the Fruits of Bupleurum rotundifolium
Toshihiro Fujioka; Keisuke Yoshida; Hiroko Shibao; Tsuneatsu Nagao; Miyako Yoshida; Kazuhisa Matsunaga; Jiro Takata; Yoshiharu Karube; Yukiko Iwase; Hikaru Okabe; Kunihide Mihashi
CHEMICAL & PHARMACEUTICAL BULLETIN, Dec. 2006, 54(12):1694 - 1704

水溶性ビタミンKプロドラッグの骨粗鬆症予防効果に関する研究
第16回総合健康推進財団研究報告書, Feb. 2002

製剤化のサイエンス改訂11版
MATSUNAGA Kazuhisa; KOGA Mitsuhisa; SETOGUCHI Shuichi, Joint work, 第3部第3章ターゲティング1,2
ネオメディカル, Mar. 2020

製剤化のサイエンス改訂10版
TAKATA Jiro; MATSUNAGA Kazuhisa, Joint work, 第3部第3章ターゲティング
ネオメディカル, Mar. 2020

製剤化のサイエンス改訂9版
TAKATA Jiro; MATSUNAGA Kazuhisa, Joint work, 第3部第3章ターゲティング
ネオメディカル, Mar. 2019
9784904634264

放射線・放射性物質の薬学利用
KARUBE Yoshiharu; TAKATA Jiro; MATSUNAGA Kazuhisa, Joint work
廣川鉄男事務所, Feb. 2018
9784908996054

VITAMIN K2 - VITAL FOR HEALTH AND WELLBEING
MATSUNAGA Kazuhisa; ENJOJI Munechika; KARUBE Yoshiharu; TAKATA Jiro, Joint work, Chapter 17
Intech, Mar. 2017, Refereed
9789535130192

製剤化のサイエンス改訂8版
TAKATA Jiro; MATSUNAGA Kazuhisa, Joint work, 第3部第3章ターゲティング
ネオメディカル, Mar. 2017
9784904634202

薬学における放射線・放射性物質の利用 第4版
KARUBE Yoshiharu; TAKATA Jiro; MATSUNAGA Kazuhisa, Joint work
KYOTO HIROKAWA, Mar. 2016

製剤化のサイエンス改訂7版
TAKATA Jiro; MATSUNAGA Kazuhisa, Joint work
ネオメディカル, Mar. 2015
9784904634059

製剤化のサイエンス改訂6版
Joint work
ネオメディカル, Mar. 2013
9784904634059

趣味の文具箱 vol.23
Contributor, 106-107
Aug. 2012
9784777924691

製剤化のサイエンス改訂5版
Joint work
ネオメディカル, Mar. 2012
9784904634059

薬学における放射線・放射性物質の利用 第3版
KARUBE Yoshiharu; TAKATA Jiro; MATSUNAGA Kazuhisa, Joint work
KYOTO HIROKAWA, Feb. 2012

ビタミンEのパラダイムシフトとアンチエイジング化粧品
松永和久; 長田(赤穂)菜美; 田二郎
シーエムシー出版 (月刊バイオインダストリー), Aug. 2010

趣味の文具箱 vol.16
Contributor, 64-67
Mar. 2010
9784777915835

薬学における 放射線・放射性物質の利用 第2版
塩井誠次郎; 加留部善晴; 高田二郎; 松永和久; 赤穂菜美; 楠田真理子; 渡瀬大輔, Joint work
京都廣川書店, Jan. 2010

薬学における放射線・放射性物質の利用
KARUBE Yoshiharu; TAKATA Jiro; MATSUNAGA Kazuhisa, Joint work
KYOTO HIROKAWA, Feb. 2009

薬学生のための放射線・放射性物質
廣川書店, Dec. 2007

Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma
International Drug Discovery Science and Technology Japan 2017 (Osaka), Jul. 2017

ピロー包装開封後保存で、崩壊性が変化した口腔内崩壊錠の一例
松永和久; 犬山智香子; 瀬戸口修一; 加留部善晴; 高田二郎
日本薬学会第134年会, 30 Mar. 2014

ビタミンEカチオン性エステル誘導体の消化管吸収に及ぼす胆汁酸アニオンの役割
KUSUDA Mariko; AKAHO Nami; MATSUNAGA Kazuhisa; KARUBE Yoshiharu; TAKATA Jiro
第25回ビタミンE研究会, 24 Jan. 2014

ビタミンE誘導体の消化管吸収に関する研究
KUSUDA Mariko; AKAHO Nami; MATSUNAGA Kazuhisa; KARUBE Yoshiharu; TAKATA Jiro
2013年度日本ビタミン学会近畿・中国四国・九州沖縄地区合同大会, 06 Sep. 2013

肝細胞癌再発予防薬としてのメナハイドロキノン-4 プロドラッグの投与設計と動態比較
KUSUDA Mariko; AKAHO Nami; MATSUNAGA Kazuhisa; KARUBE Yoshiharu; TAKATA Jiro
2013年度日本ビタミン学会近畿・中国四国・九州沖縄地区合同大会, 06 Sep. 2013

メナヒドロキノン-4コハク酸エステルによる肝細胞がんに対する活性型ビタミンKの効率的な送達ならびに増殖抑制
KUSUDA Mariko; AKAHO Nami; MATSUNAGA Kazuhisa; KARUBE Yoshiharu; TAKATA Jiro
第65回日本ビタミン学会大会, 18 May 2013

LIPID IS ABSORBED BY EPITHELIAL NEOPLASIA (ADENOMA AND EARLY CANCER) IN THE STOMACH: A NOVEL FINDING
K. Ohtsu; K. Yao; K. Matsunaga; T. Nagahama; T. Kanemitsu; M. Yasaka; S. Fujiwara; F. Hirai; T. Mastui; T. Hanada; A. Iwashita; N. Uedo
20th United European Gastroenterology Week, Oct. 2012

マウスにおける骨髄抑制状態の定量的検出法の確立
KUSUDA Mariko; AKAHO Nami; MATSUNAGA Kazuhisa; TAKATA Jiro; KARUBE Yoshiharu
医療薬学フォーラム2012 第20回クリニカルファーマシーシンポジウム, 15 Jul. 2012

クリープメータを用いた口腔内崩壊錠の崩壊特性の検討
MATSUNAGA Kazuhisa; TAKATA Jiro; KARUBE Yoshiharu
日本薬剤学会第27年会, 24 May 2012

肝細胞癌細胞におけるビタミンKサイクル依存性および非依存性の活性型ビタミンK送達法の比較
KUSUDA Mariko; AKAHO Nami; MATSUNAGA Kazuhisa; KARUBE Yoshiharu; TAKATA Jiro
日本薬剤学会第27年会, 24 May 2012

骨髄抑制モデルマウスによる骨髄抑制軽減物質の探索
KUSUDA Mariko; AKAHO Nami; MATSUNAGA Kazuhisa; TAKATA Jiro; KARUBE Yoshiharu
第28回日本薬学会九州支部大会, 11 Dec. 2011

活性型ビタミンK送達システムによる肝細胞癌再発抑制剤の開発
KUSUDA Mariko; AKAHO Nami; MATSUNAGA Kazuhisa; KARUBE Yoshiharu; TAKATA Jiro
日本ビタミン学会 第63回大会, 05 Jun. 2011

DRG-targeted gene therapy for sensory neuronopathies in mouse models of diabetes
Kazuhisa Matsunaga; Tomoya Terashima; Lawrence Chan; Kazuhiro Oka
Cell and Gene Therapy 2010 Conference, 18 Nov. 2010

Derivatives of vitamin K design to enhance Menahydroquinone-4 (MKH) accumulation in hepatocellular carcinoma (HCC) cells
KUSUDA Mariko; WATASE Daisuke; AKAHO Nami; MATSUNAGA Kazuhisa; NAKASHIMA Manabu; ENJOJI Munechika; KARUBE Yoshiharu; TAKATA Jiro
The 69th Annual Meeting of the Japanese Cancer Association, 24 Sep. 2010

BIOREDUCTIVE ACTIVATION-INDEPENDENT DELIVERY SYSTEM OF MENAHYDROQUINONE-4 AS EFFECTIVE AND SAFE ANTITUMOR AGENTS
MATSUNAGA Kazuhisa; AKAHO Nami; KUSUDA Mariko; NAKASHIMA Manabu; ENJOJI Munechika; TAKESHITA Morishige; KARUBE Yoshiharu; TAKATA Jiro
Asian Federation for Pharmaceutical Sciences 2009, 17 Oct. 2009

Antitumor activity of menahydroquinone derivatives against nonhepatic tumor cells
MATSUNAGA Kazuhisa; AKAHO Nami; KUSUDA Mariko; NAKASHIMA Manabu; ENJOJI Munechika; TAKESHITA Morishige; KARUBE Yoshiharu; TAKATA Jiro
The 68th Annual Meeting of the Japanese Cancer Association, 03 Oct. 2009

脂溶性ビタミン類の水溶性誘導体化による新規機能性化合物
Innovation JAPAN 2009, 18 Sep. 2009

Hepatocellular carcinoma cell specific delivery system of menahydroquinone-4 for antitumor drugs
Kazuhisa Matsunaga; Yuji Trio; Mariko Kusuda; Morishige Takeshita; Manabu Nakashima; Yoshiharu Karube; Jiro Takata
第67回日本癌学会学術総会, 29 Oct. 2008

Antitumor activity of derivatives of menahydroquinone, an active form of menatetrenone
MATSUNAGA Kazuhisa; NAKASHIMA Manabu; TAKESHITA Morishige; KARUBE Yoshiharu; TAKATA Jiro
The 66th Annual Meeting of the Japanese Cancer Association, 03 Oct. 2007

プロテアーゼ抵抗性プリオン蛋白発現に及ぼす海藻由来水溶性多糖成分の影響
福岡大; 薬; 長崎大; 医; 酒井恵子; 吉田都; 西田教行; 松永和久; 山内淳史; 高田二郎; 加留部善晴; 片岡泰文; 片峰茂; 藤岡稔大
日本薬学会第１２５年会, 30 Mar. 2005

製剤学
福岡大学

同位体化学
福岡大学

同位体医療薬学
福岡大学

物理薬剤学
福岡大学

薬物送達学
福岡大学

放射実習
福岡大学

製剤実習
福岡大学

The Academy of Pharmaceutical Science and Technology, Japan

The Vitamin Society of Japan

Japanese Cancer Association

The Pharmaceutical Society of Japan

イソプレニル基を有するビタミン類の誘導体化による新規治療薬の開発
日本学術振興会, 科学研究費助成事業, 若手研究(B)
福岡大学
2002 - 2004

糖類の標識デザインとその機能性製剤の調製に関する研究
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
2001 - 2002

5515078, 虚血性障害抑制剤

US 8,242,302 B2, Inhibitor of Ischemic Disorders

4040082, ビタミンＫヒドロキノン誘導体を用いる癌治療剤および再発予防剤

2005-119989, 新規1,4-ベンゼンジオールカルボン酸エステル誘導体又はその塩、その製造方法及びそれを含有する皮膚外用剤

2005-119990, 皮膚外用剤

2005-119991, 皮膚外用剤

EP1446095, SKIN PREPARATION COMPRISING A TOCOPHEROL DERIVATIVE FOR EXTERNAL APPLICATION

2004-002277, 皮膚外用剤

2004-002278, 皮膚外用剤

6,599,933 B2, Tocotrienol derivative, process for producing the same and γ-CEHC delivering agent

2003-104945, ２，３－ジメトキシ－５－メチル－１，４－ジヒドロキシベンゼン誘導体およびその製造方法

2002-332231, γ－CEHC送達剤

2002-255809, 水溶性6-クロマノールカルボン酸エステル誘導体を含む経口投与剤

2002-80475, トコトリエノール誘導体及びその製造方法

新規万年筆用インクに関する技術指導
informant
01 Sep. 2016