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Last Updated :2024/03/03

藤田 孝之

医学科
教授

プロフィール日本内科学会 総合内科専門医 日本循環器学会 循環器専門医 日本老年医学会 老年科専門医 日本高血圧学会 高血圧専門医 日本生理学会 評議員 日本薬理学会 学術評議員 Fellow of the American College of Physicians (FACP) Fellow of the American Heart Association (FAHA)

研究者情報

■ 学位
  • 博士(医学)
■ 研究キーワード
  • 心疾患
  • EPAC
  • 高血圧
  • p53
  • 分子心臓病態学
  • 自律神経
  • 心機能制御
  • 生理学
  • カテコラミン
  • cAMP
  • 分子
  • 循環器・高血圧
  • シグナル伝達
■ 研究分野
  • ライフサイエンス, 循環器内科学
  • ライフサイエンス, 医療薬学
  • ライフサイエンス, 生理学

研究活動情報

■ 論文
  • Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation.
    Taro Hiromi; Utako Yokoyama; Daisuke Kurotaki; Al Mamun; Ryo Ishiwata; Yasuhiro Ichikawa; Hiroshi Nishihara; Masanari Umemura; Takayuki Fujita; Shota Yasuda; Tomoyuki Minami; Motohiko Goda; Keiji Uchida; Shinichi Suzuki; Ichiro Takeuchi; Munetaka Masuda; Richard M Breyer; Tomohiko Tamura; Yoshihiro Ishikawa
    Arteriosclerosis, thrombosis, and vascular biology, 2020年04月23日, 査読有り, 通常論文
  • Fibulin-1 integrates subendothelial extracellular matrices and contributes to anatomical closure of the ductus arteriosus
    Ito S; Yokoyama U; Nakakoji T; Cooley M; Sasaki T; Hatano S; Kato Y; Saito J; Nicho N; Iwasaki S; Umemura M; Fujita T; Masuda M; Aso T; Ishikawa T
    Arteriosclerosis, Thrombosis, and Vascular Biology, 2020年, 査読有り, 通常論文
  • Prostaglandin E2 receptor EP4 regulates cell migration via Orai1.
    Osawa K; Umemura M; Nakakaji R; Tanaka R; Islam RM; Nagasako A; Fujita T; Yokoyama U; Koizumi T; Mitsudo K; Ishikawa Y
    Cancer science, 2019年11月, 査読有り, 通常論文
  • Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism.
    Cell Death Dis., 2019年07月, 査読有り, 通常論文, 責任著者
  • Correction to: Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.
    Huiling Jin; Takayuki Fujita; Meihua Jin; Reiko Kurotani; Yuko Hidaka; Wenqian Cai; Kenji Suita; Rajesh Prajapati; Chen Liang; Yoshiki Ohnuki; Yasumasa Mototani; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Satoshi Okumura; Yoshihiro Ishikawa
    The journal of physiological sciences : JPS, 2019年05月
  • Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration.
    Yuko Kato; Utako Yokoyama; Takayuki Fujita; Masanari Umemura; Tetsuo Kubota; Yoshihiro Ishikawa
    The journal of physiological sciences : JPS, 2019年03月, 査読有り, 通常論文
  • Reactive Fibrosis Precedes Doxorubicin-induced Heart Failure through Sterile Inflammation, and Pioglitazone Reduces Early Cardiac Remodelling
    Tanaka R; Umemura M; Narikawa M; Hikichi M; Osawa K; Fujita T; Yokoyama U; Ishigami T; Kimura K; Tamura K; Ishikawa Y
    ESC Heart Failure. in press, 2019年, 査読有り, 通常論文
  • Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways.
    Narikawa M; Umemura M; Tanaka R; Hikichi M; Nagasako A; Fujita T; Yokoyama U; Ishigami T; Kimura K; Tamura K; Ishikawa Y
    PloS one, 2019年, 査読有り, 通常論文
  • Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice.
    Rajesh Prajapati; Takayuki Fujita; Kenji Suita; Takashi Nakamura; Wenqian Cai; Yuko Hidaka; Masanari Umemura; Utako Yokoyama; Björn C Knollmann; Satoshi Okumura; Yoshihiro Ishikawa
    Circ J., 2019年01月, 査読有り, 通常論文, 責任著者
  • Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling.
    Narikawa M; Umemura M; Tanaka R; Fujita T; Yokoyama U; Ishigami T; Kimura K; Tamura K; Ishikawa Y
    Scientific reports, 2018年12月01日, 査読有り, 通常論文
  • Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor.
    Umemura M; Islam MR; Fukumura H; Sato I; Kawabata Y; Matsuo K; Nakakaji R; Nagasako A; Ohtake M; Fujita T; Yokoyama U; Nakayama T; Eguchi H; Ishikawa Y
    Cancer science, 2018年10月, 査読有り, 通常論文
  • A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm.
    Mamun A; Yokoyama U; Saito J; Ito S; Hiromi T; Umemura M; Fujita T; Yasuda S; Minami T; Goda M; Uchida K; Suzuki S; Masuda M; Ishikawa Y
    Physiological reports, 2018年09月, 査読有り, 通常論文
  • Alternating magnetic field enhances cytotoxicity of Compound C.
    Akimoto T; Umemura M; Nagasako A; Ohtake M; Fujita T; Yokoyama U; Eguchi H; Yamamoto T; Ishikawa Y
    Cancer science, 2018年08月, 査読有り, 通常論文
  • Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice
    Kenji Suita; Takayuki Fujita; Wenqian Cai; Yuko Hidaka; Huiling Jin; Rajesh Prajapati; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Björn C. Knollmann; Satoshi Okumura; Yoshihiro Ishikawa
    Pflugers Archiv European Journal of Physiology, 2018年06月01日, 査読有り, 通常論文
  • Hydrostatic pressure suppresses fibrotic changes via Akt/GSK-3 signaling in human cardiac fibroblasts
    Ryo Tanaka; Masanari Umemura; Masatoshi Narikawa; Takayuki Fujita; Utako Yokoyama; Tomoaki Ishigami; Kazuo Kimura; Kouichi Tamura; Yoshihiro Ishikawa
    Physiological Reports, 2018年05月01日, 査読有り, 通常論文
  • Epac activation inhibits IL-6-induced cardiac myocyte dysfunction
    Huiling Jin; Takayuki Fujita; Meihua Jin; Reiko Kurotani; Yuko Hidaka; Wenqian Cai; Kenji Suita; Rajesh Prajapati; Chen Liang; Yoshiki Ohnuki; Yasumasa Mototani; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Satoshi Okumura; Yoshihiro Ishikawa
    Journal of Physiological Sciences, 2018年01月01日, 査読有り, 通常論文
  • Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus
    Junichi Saito; Utako Yokoyama; Naoki Nicho; Yun-Wen Zheng; Yasuhiro Ichikawa; Satoko Ito; Masanari Umemura; Takayuki Fujita; Shuichi Ito; Hideki Taniguchi; Toshihide Asou; Munetaka Masuda; Yoshihiro Ishikawa
    PLoS ONE, 2018年01月01日, 査読有り, 通常論文
  • Treatment of oral cancer using magnetized paclitaxel
    Rina Nakakaji; Masanari Umemura; Kenji Mitsudo; Jeong-Hwan Kim; Yujiro Hoshino; Itaru Sato; Takatsugu Masuda; Masahiro Yamamoto; Mitomu Kioi; Toshiyuki Koizumi; Takayuki Fujita; Utako Yokoyama; Masaki Iida; Motohiko Sato; Hiroshi Sato; Shoko Murofushi; Sayaka Shibata; Ichio Aoki; Haruki Eguchi; Iwai Tohnai; Yoshihiro Ishikawa
    Oncotarget, 2018年, 査読有り, 通常論文
  • The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity
    Masanari Umemura; Jeong-Hwan Kim; Haruki Aoyama; Yujiro Hoshino; Hidenobu Fukumura; Rina Nakakaji; Itaru Sato; Makoto Ohtake; Taisuke Akimoto; Masatoshi Narikawa; Ryo Tanaka; Takayuki Fujita; Utako Yokoyama; Masataka Taguri; Satoshi Okumura; Motohiko Sato; Haruki Eguchi; Yoshihiro Ishikawa
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2017年08月, 査読有り, 通常論文
  • Transient receptor potential cation 3 channel regulates melanoma proliferation and migration
    Kayoko Oda; Masanari Umemura; Rina Nakakaji; Ryo Tanaka; Itaru Sato; Akane Nagasako; Chiaki Oyamada; Erdene Baljinnyam; Mayumi Katsumata; Lai-Hua Xie; Masatoshi Narikawa; Yukie Yamaguchi; Taisuke Akimoto; Makoto Ohtake; Takayuki Fujita; Utako Yokoyama; Kousaku Iwatsubo; Michiko Aihara; Yoshihiro Ishikawa
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2017年07月, 査読有り, 通常論文
  • Cardiac overexpression of Epacl in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway
    Huiling Jin; Takayuki Fujita; Meihua Jin; Reiko Kurotani; Iyuki Namekata; Shogo Hamaguchi; Yuko Hidaka; Wenqian Cai; Kenji Suita; Yoshiki Ohnuki; Yasumasa Mototani; Kouichi Shiozawa; Rajesh Prajapati; Chen Liang; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Hikaru Tanaka; Satoshi Okumura; Yoshihiro Ishikawa
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2017年07月, 査読有り, 通常論文
  • Arterial graft with elastic layer structure grown from cells
    Utako Yokoyama; Yuta Tonooka; Ryoma Koretake; Taisuke Akimoto; Yuki Gonda; Junichi Saito; Masanari Umemura; Takayuki Fujita; Shinya Sakuma; Fumihito Arai; Makoto Kaneko; Yoshihiro Ishikawa
    SCIENTIFIC REPORTS, 2017年03月, 査読有り, 通常論文
  • Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment
    Makoto Ohtake; Masanari Umemura; Itaru Sato; Taisuke Akimoto; Kayoko Oda; Akane Nagasako; Jeong-Hwan Kim; Takayuki Fujita; Utako Yokoyama; Tomohiro Nakayama; Yujiro Hoshino; Mai Ishiba; Susumu Tokura; Masakazu Hara; Tomoya Muramoto; Sotoshi Yamada; Takatsugu Masuda; Ichio Aoki; Yasushi Takemura; Hidetoshi Murata; Haruki Eguchi; Nobutaka Kawahara; Yoshihiro Ishikawa
    Scientific Reports, 2017年02月20日, 査読有り, 通常論文
  • The role of Epac in the heart
    Takayuki Fujita; Masanari Umemura; Utako Yokoyama; Satoshi Okumura; Yoshihiro Ishikawa
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2017年02月, 査読有り, 通常論文
  • Vidarabine, an Anti-Herpes Virus Agent, Protects Against the Development of Heart Failure With Relatively Mild Side-Effects on Cardiac Function in a Canine Model of Pacing-Induced Dilated Cardiomyopathy
    Takashi Nakamura; Takayuki Fujita; Megumi Kishimura; Kenji Suita; Yuko Hidaka; Wenqian Cai; Masanari Umemura; Utako Yokoyama; Masami Uechi; Yoshihiro Ishikawa
    CIRCULATION JOURNAL, 2016年12月, 査読有り, 通常論文
  • Glutamate Promotes Contraction of the Rat Ductus Arteriosus
    Shujiro Fujita; Utako Yokoyama; Ryo Ishiwata; Rika Aoki; Kenji Nagao; Daiki Masukawa; Masanari Umemura; Takayuki Fujita; Shiho Iwasaki; Shigeru Nishimaki; Kazuo Seki; Shuichi Ito; Yoshio Goshima; Toshihide Asou; Munetaka Masuda; Yoshihiro Ishikawa
    CIRCULATION JOURNAL, 2016年11月, 査読有り, 通常論文
  • Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction
    Wenqian Cai; Takayuki Fujita; Yuko Hidaka; Huiling Jin; Kenji Suita; Rajesh Prajapati; Chen Liang; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Satoshi Okumura; Yoshihiro Ishikawa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016年06月, 査読有り, 通常論文
  • Role of phosphodiesterase 4 expression in the Epac1 signaling-dependent skeletal muscle hypertrophic action of clenbuterol
    Yoshiki Ohnuki; Daisuke Umeki; Yasumasa Mototani; Kouichi Shiozawa; Megumi Nariyama; Aiko Ito; Naoya Kawamura; Yuka Yagisawa; Huiling Jin; Wenqian Cai; Kenji Suita; Yasutake Saeki; Takayuki Fujita; Yoshihiro Ishikawa; Satoshi Okumura
    Physiological Reports, 2016年05月01日, 査読有り, 通常論文
  • Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles
    Itaru Sato; Masanari Umemura; Kenji Mitsudo; Hidenobu Fukumura; Jeong-Hwan Kim; Yujiro Hoshino; Hideyuki Nakashima; Mitomu Kioi; Rina Nakakaji; Motohiko Sato; Takayuki Fujita; Utako Yokoyama; Satoshi Okumura; Hisashi Oshiro; Haruki Eguchi; Iwai Tohnai; Yoshihiro Ishikawa
    SCIENTIFIC REPORTS, 2016年04月, 査読有り, 通常論文
  • Decreased serum osmolality promotes ductus arteriosus constriction
    Rika Aoki; Utako Yokoyama; Yasuhiro Ichikawa; Masataka Taguri; Shun Kumagaya; Ryo Ishiwata; Chiharu Yanai; Shujiro Fujita; Masanari Umemura; Takayuki Fujita; Satoshi Okumura; Motohiko Sato; Susumu Minamisawa; Toshihide Asou; Munetaka Masuda; Shiho Iwasaki; Shigeru Nishimaki; Kazuo Seki; Shumpei Yokota; Yoshihiro Ishikawa
    CARDIOVASCULAR RESEARCH, 2014年11月, 査読有り, 通常論文
  • Effects of Protein Kinase A on the Phosphorylation Status and Transverse Stiffness of Cardiac Myofibrils
    Yoshiki Ohnuki; Takenori Yamada; Yasumasa Mototani; Daisuke Umeki; Kouichi Shiozawa; Takayuki Fujita; Yasutake Saeki; Satoshi Okumura
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013年11月, 査読有り, 通常論文
  • Role of Masseter Muscle beta(2)-Adrenergic Signaling in Regulation of Muscle Activity, Myosin Heavy Chain Transition, and Hypertrophy
    Yoshiki Ohnuki; Daisuke Umeki; Wenqian Cai; Nobuhiko Kawai; Yasumasa Mototani; Kouichi Shiozawa; Hui-Ling Jin; Takayuki Fujita; Eiji Tanaka; Yasutake Saeki; Satoshi Okumura
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013年09月, 査読有り, 通常論文
  • Effects of Chronic Akt/mTOR Inhibition by Rapamycin on Mechanical Overload-Induced Hypertrophy and Myosin Heavy Chain Transition in Masseter Muscle
    Daisuke Umeki; Yoshiki Ohnuki; Yasumasa Mototani; Kouichi Shiozawa; Takayuki Fujita; Yoshiki Nakamura; Yasutake Saeki; Satoshi Okumura
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013年08月, 査読有り, 通常論文
  • The Prostanoid EP4 Receptor and Its Signaling Pathway
    Utako Yokoyama; Kousaku Iwatsubo; Masanari Umemura; Takayuki Fujita; Yoshihiro Ishikawa
    PHARMACOLOGICAL REVIEWS, 2013年07月, 査読有り, 通常論文
  • Low-dose thromboxane A(2) receptor stimulation promotes closure of the rat ductus arteriosus with minimal adverse effects
    Tomohiro Yokota; Takashi Aida; Yasuhiro Ichikawa; Takayuki Fujita; Utako Yokoyama; Susumu Minamisawa
    PEDIATRIC RESEARCH, 2012年08月, 査読有り, 通常論文
  • Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight
    Yunzhe Bai; Takashi Tsunematsu; Qibin Jiao; Yoshiki Ohnuki; Yasumasa Mototani; Kouichi Shiozawa; Meihua Jin; Wenqian Cai; Hui-Ling Jin; Takayuki Fujita; Yasuhiro Ichikawa; Kenji Suita; Reiko Kurotani; Utako Yokoyama; Motohiko Sato; Kousaku Iwatsubo; Yoshihiro Ishikawa; Satoshi Okumura
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012年08月, 査読有り, 通常論文
  • Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells
    Hidenobu Fukumura; Motohiko Sato; Kyouhei Kezuka; Itaru Sato; Xianfeng Feng; Satoshi Okumura; Takayuki Fujita; Utako Yokoyama; Haruki Eguchi; Yoshihiro Ishikawa; Tomoyuki Saito
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2012年05月, 査読有り, 通常論文
  • Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation
    Utako Yokoyama; Ryo Ishiwata; Mei-Hua Jin; Yuko Kato; Orie Suzuki; Huiling Jin; Yasuhiro Ichikawa; Syun Kumagaya; Yuzo Katayama; Takayuki Fujita; Satoshi Okumura; Motohiko Sato; Yukihiko Sugimoto; Hiroki Aoki; Shinichi Suzuki; Munetaka Masuda; Susumu Minamisawa; Yoshihiro Ishikawa
    PLOS ONE, 2012年05月, 査読有り, 通常論文
  • The Roles of Cytochrome P450 in Ischemic Heart Disease
    Motohiko Sato; Utako Yokoyama; Takayuki Fujita; Satoshi Okumura; Yoshihioro Ishikawa
    CURRENT DRUG METABOLISM, 2011年07月, 査読有り, 通常論文
  • Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca2+-dependent manner
    Takayuki Fujita; Kouji Otsu; An Oshikawa; Hideaki Hori; Hitoshi Kitamura; Takaaki Ito; Satoshi Umemura; Susumu Minamisawa; Yoshihiro Ishikawa
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2006年01月, 査読有り, 通常論文
  • Nicotinic acetylcholine receptor alpha(7) regulates cAMP signal within lipid rafts
    J Oshikawa; Y Toya; T Fujita; M Egawa; J Kawabe; S Umemura; Y Ishikawa
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2003年09月, 査読有り, 通常論文
  • Ischemic preconditioning prevents ischemia-induced beta-adrenergic receptor sequestration
    K Iwatsubo; Y Toya; T Fujita; T Ebina; C Schwencke; S Minamisawa; S Umemura; Y Ishikawa
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2003年08月, 査読有り, 通常論文
  • Characterization of beta-adrenergic receptor sequestration by newly developed whole cell binding assays.
    Iwatsubo K; Tao Y; Onda T; Toya Y; Schwencke C; Fujita T; Ebina T; Iwamoto T; Hori H; Minamisawa S; Umemura S; Ishikawa Y
    Journal of cardiovascular pharmacology, 2003年01月, 査読有り, 通常論文
■ MISC
  • 生体侵襲とショックの基礎病態学、今 急性と慢性 心不全はどこがちがうのか?
    石川 義弘; 藤田 孝之; 梅村 将就; 横山 詩子
    Shock: 日本Shock学会雑誌, 2019年02月, 査読無し, 通常論文
  • Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation
    Yuko Kato; Utako Yokoyama; Chiharu Yanai; Rina Ishige; Daisuke Kurotaki; Masanari Umemura; Takayuki Fujita; Tetsuo Kubota; Satoshi Okumura; Masataka Sata; Tomohiko Tamura; Yoshihiro Ishikawa
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2015年12月, 査読無し, 通常論文
  • Norepinephrine-induced adrenergic activation strikingly increased the atrial fibrillation duration through (β1- and α1-adrenergic receptor-mediated signaling in mice
    Kenji Suita; Takayuki Fujita; Nozomi Hasegawa; Wenqian Cai; Huiling Jin; Yuko Hidaka; Rajesh Prajapati; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Motohiko Sato; Satoshi Okumura; Satoshi Okumura; Yoshihiro Ishikawa
    PLoS ONE, 2015年07月, 査読無し, 通常論文
  • Protective Effects of Clenbuterol against Dexamethasone-Induced Masseter Muscle Atrophy and Myosin Heavy Chain Transition
    Daisuke Umeki; Yoshiki Ohnuki; Yasumasa Mototani; Kouichi Shiozawa; Kenji Suita; Takayuki Fujita; Yoshiki Nakamura; Yasutake Saeki; Satoshi Okumura
    PLOS ONE, 2015年06月, 査読無し, 通常論文
  • 心肥大と心不全
    石川義弘; 藤田孝之; 梅村将就; 横山詩子
    日本病態生理学会雑誌, 2015年05月20日, 査読無し, 通常論文
  • Oscillation of cAMP and Ca2+ in cardiac myocytes: a systems biology approach
    Takehisa Kamide; Satoshi Okumura; Samik Ghosh; Yoko Shinoda; Yasumasa Mototani; Yoshiki Ohnuki; Huiling Jin; Wenqian Cai; Kenji Suita; Itaru Sato; Masanari Umemura; Takayuki Fujita; Utako Yokoyama; Motohiko Sato; Kazuharu Furutani; Hiroaki Kitano; Yoshihiro Ishikawa
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2015年03月, 査読無し, 通常論文
  • Coupling of β1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes
    Takashi Tsunematsu; Satoshi Okumura; Satoshi Okumura; Yasumasa Mototani; Yoshiki Ohnuki; Huiling Jin; Wenqian Cai; Kenji Suita; Itaru Sato; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Motohiko Sato; Takayuki Fujita; Yoshihiro Ishikawa
    Biochemical and Biophysical Research Communications, 2015年03月, 査読無し, 通常論文
  • Role of cyclic AMP sensor Epac1 in masseter muscle hypertrophy and myosin heavy chain transition induced by β2-adrenoceptor stimulation
    Yoshiki Ohnuki; Daisuke Umeki; Daisuke Umeki; Yasumasa Mototani; Huiling Jin; Wenqian Cai; Kouichi Shiozawa; Kenji Suita; Yasutake Saeki; Takayuki Fujita; Yoshihiro Ishikawa; Satoshi Okumura; Satoshi Okumura
    Journal of Physiology, 2014年12月, 査読無し, 通常論文
  • Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses
    Satoshi Okumura; Takayuki Fujita; Wenqian Cai; Meihua Jin; Iyuki Namekata; Yasumasa Mototani; Huiling Jin; Yoshiki Ohnuki; Yayoi Tsuneoka; Reiko Kurotani; Kenji Suita; Yuko Kawakami; Shogo Hamaguchi; Takaya Abe; Hiroshi Kiyonari; Takashi Tsunematsu; Yunzhe Bai; Sayaka Suzuki; Yuko Hidaka; Masanari Umemura; Yasuhiro Ichikawa; Utako Yokoyama; Motohiko Sato; Fumio Ishikawa; Hiroko Izumi-Nakaseko; Satomi Adachi-Akahane; Hikaru Tanaka; Yoshihiro Ishikawa
    JOURNAL OF CLINICAL INVESTIGATION, 2014年06月, 査読無し, 通常論文
  • Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells
    Itaru Sato; Itaru Sato; Masanari Umemura; Kenji Mitsudo; Mitomu Kioi; Hideyuki Nakashima; Toshinori Iwai; Xianfeng Feng; Kayoko Oda; Akiyoshi Miyajima; Ayako Makino; Maki Iwai; Takayuki Fujita; Utako Yokoyama; Satoshi Okumura; Motohiko Sato; Haruki Eguchi; Iwai Tohnai; Yoshihiro Ishikawa
    Journal of Physiological Sciences, 2014年05月, 査読無し, 通常論文
  • Three-dimensional multilayers of smooth muscle cells as a new experimental model for vascular elastic fiber formation studies
    Ryo Ishiwata; Utako Yokoyama; Michiya Matsusaki; Yoshiya Asano; Koji Kadowaki; Yasuhiro Ichikawa; Masanari Umemura; Takayuki Fujita; Susumu Minamisawa; Hiroshi Shimoda; Mitsuru Akashi; Yoshihiro Ishikawa
    ATHEROSCLEROSIS, 2014年04月, 査読無し, 通常論文
  • Protection of Cardiomyocytes from the Hypoxia-Mediated Injury by a Peptide Targeting the Activator of G-Protein Signaling 8
    Motohiko Sato; Masahiro Hiraoka; Hiroko Suzuki; Miho Sakima; Abdullah Al Mamun; Yukiko Yamane; Takayuki Fujita; Utako Yokoyama; Satoshi Okumura; Yoshihiro Ishikawa
    PLOS ONE, 2014年03月, 査読無し, 通常論文
  • Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration
    Masanari Umemura; Erdene Baljinnyam; Stefan Feske; Mariana S. De Lorenzo; Lai-Hua Xie; Xianfeng Feng; Kayoko Oda; Ayako Makino; Takayuki Fujita; Utako Yokoyama; Mizuka Iwatsubo; Suzie Chen; James S. Goydos; Yoshihiro Ishikawa; Kousaku Iwatsubo
    PLOS ONE, 2014年02月, 査読無し, 通常論文
  • Pharmacological inhibition of STAT 3 protect heart from lipopolysaccharide-induced cardiac dysfunction through the inhibition of Jak2/STAT3/iNOS signaling
    Jin Huiling; Satoshi Okumura; Jin Meihua; Cai Wenqian; Kenji Suita; Takashi Tsunematsu; Bai Yunzhe; Takayuki Fujita; Yoshihiro Ishikawa
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013年, 査読無し, 通常論文
  • TCTP/Fortilin regulates survival of carcinoma cells and cardiomyocytes
    Takayuki Fujita; Wenqian Cai; Yuko Hidaka; Huiling Jin; Meihua Jin; Kenji Suita; Yoshihiro Ishikawa
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013年, 査読無し, 通常論文
  • Epac1 pathway plays an important role for the development of heart failure through the activation of PKA
    Cai Wenqian; Satoshi Okumura; Takayuki Fujita; Jin Meihua; Kenji Suita; Jin Huiling; Yuko Hidaka; Yoshihiro Ishikawa
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013年, 査読無し, 通常論文
  • Vidarabine, an anti-herpesvirus agent, prevents atrial fibrillation in mice
    Kenji Suite; Cai Wenqian; Jin Huiling; Jin Meihua; Takayuki Fujita; Satoshi Okumura; Yoshihiro Ishikawa
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013年, 査読無し, 通常論文
  • The function of Store-operated Ca2+ entry(SOCE)in melanoma
    Masanari Umemura; Takayuki Fujita; Utako Yokoyama; Yoshihiro Ishikawa; Kousaku Iwatsubo
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013年, 査読無し, 通常論文
  • Disruption of Epaci Decreases Phosphorylation of Phospholamban and Protects the Heart Against Stresses
    Satoshi Okumura; Meihua Jin; Yoshiki Ohnuki; Iyuki Namekata; Reiko Kurotani; Takayuki Fujita; Hui-Ling Jin; Weniqian Cai; Yunzhe Bai; Kenji Suita; Takashi Tsunematsu; Hikaru Tanaka; Yoshihiro Ishikawa
    CIRCULATION, 2012年11月, 査読無し, 通常論文
  • Stimulation of thromboxane A(2) receptor induced the constriction and remodeling of the ductus arteriosus in the rat
    Tomohiro Yokota; Takashi Aida; Ryosuke Shiraishi; Yasuhiro Ichikawa; Takayuki Fujita; Utako Yokoyama
    FASEB JOURNAL, 2012年04月, 査読無し, 通常論文
  • Apoptosis in Heart Failure: The role of the β-adrenergic receptor-mediated signaling pathway and p53-mediated signaling pathway in the apoptosis of cardiomyocytes
    Takayuki Fujita; Yoshihiro Ishikawa
    Circulation Journal, 2011年08月, 査読無し, 通常論文
■ 共同研究・競争的資金等の研究課題
  • 高リスク心疾患に対する栄養・加齢・幹細胞の炎症への影響と組織再生能評価
    挑戦的研究(萌芽)
    横浜市立大学
    2021年07月09日 - 2024年03月31日
  • 高リスク心筋梗塞に対する運動介入効果による加齢への影響と組織再生能評価
    挑戦的研究(萌芽)
    横浜市立大学
    2018年06月29日 - 2023年03月31日
  • 交感神経による有害作用の選択的遮断等による,安全な心疾患治療の確立についての検討
    基盤研究(C)
    2019年04月01日 - 2022年03月31日
  • 循環制御におけるホメオスタシスの破綻予測
    基盤研究(C)
    横浜市立大学
    2018年07月18日 - 2021年03月31日
  • 新規cAMP標的分子“EPAC”の動脈硬化発症における役割
    基盤研究(C)
    横浜市立大学
    2016年04月01日 - 2019年03月31日
  • 新規cAMP標的分子 EPAC の高血圧発症における役割
    基盤研究(C)
    横浜市立大学
    2013年04月01日 - 2016年03月31日
  • 自律神経による心機能制御の分子メカニズム
    基盤研究(B)
    横浜市立大学
    2012年04月01日 - 2016年03月31日
  • 心筋細胞シグナルパスウェイ制御機構と神経性調節の統合的解明
    新学術領域研究(研究領域提案型)
    横浜市立大学
    2010年04月01日 - 2015年03月31日
  • 新たなp53機能制御タンパク"Fortilin"を介した心疾患制御の可能性
    若手研究(B)
    横浜市立大学
    2009年 - 2011年