Jun. 2021
Genes and Environment, Best Paper Award 2020

Jun. 2015
日本毒性学会, 田邊賞
倉岡功

Nov. 2007
日本環境変異原学会, 奨励賞
倉岡功

Novel plasmids for the fluorescence-based evaluation of DNA mismatch repair in human cells
Arato Takedachi; Erina Matsuishi; Shouji Mizusaki; Tomoki Nagasawa; Ryosuke Fujikane; Masumi Hidaka; Shigenori Iwai; Isao Kuraoka
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Apr. 2022, Refereed
Corresponding

Arabidopsis thaliana endonuclease V is a ribonuclease specific for inosine-containing single-stranded RNA.
Megumi Endo; Jung In Kim; Narumi Aoki Shioi; Shigenori Iwai; Isao Kuraoka
Open biology, Oct. 2021
Corresponding

Acetaldehyde induces NER repairable mutagenic DNA lesions.
Yuina Sonohara; Reine Takatsuka; Chikahide Masutani; Shigenori Iwai; Isao Kuraoka
Carcinogenesis, 21 Sep. 2021, Refereed
Corresponding

Effects of acetaldehyde-induced DNA lesions on DNA metabolism
Haruka Tsuruta; Yuina Sonohara; Kosuke Tohashi; Narumi Aoki Shioi; Shigenori Iwai; Isao Kuraoka
Genes and Environment, Jan. 2020, Refereed
Corresponding

Nucleotide excision repair genes shaping embryonic development
Sofia J. Araújo; Isao Kuraoka
Open Biology, 30 Oct. 2019, Refereed
Corresponding

Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase.
Wu J; Samara NL; Kuraoka I; Yang W
Mol Cell, 03 Oct. 2019, Refereed

Acetaldehyde forms covalent GG intrastrand crosslinks in DNA.
Sonohara Y; Yamamoto J; Tohashi K; Takatsuka R; Matsuda T; Iwai S; Kuraoka I
Scientific reports, 24 Jan. 2019, Refereed
Corresponding

Alternative excision repair of topoisomerase inhibitor-induced DNA damage
Isao Kuraoka
The Nucleus, Dec. 2018, Refereed
Corresponding

Oligo swapping method for in vitro DNA repair substrate containing a single DNA lesion at a specific site.
Yukutake M; Hayashida M; Shioi Aoki N; Kuraoka I
Genes and Environment, 12 Nov. 2018, Refereed
Corresponding

Fluorescence detection of DNA mismatch repair in human cells.
Ito S; Shiraishi M; Tsuchihashi K; Takatsuka R; Yamamoto J; Kuraoka I; Iwai S
Scientific reports, 15 Aug. 2018, Refereed

An assay to detect DNA-damaging agents that induce nucleotide excision-repairable DNA lesions in living human cells
Reine Takatsuka; Shunsuke Ito; Shigenori Iwai; Isao Kuraoka
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, Aug. 2017, Refereed
Corresponding

Facile preparation of a fluorescent probe to detect the cellular ability of nucleotide excision repair
Hana Tawarahara; Isao Kuraoka; Shigenori Iwai
ANALYTICAL BIOCHEMISTRY, Jun. 2017, Refereed

Inosine-specific ribonuclease activity of natural variants of human endonuclease V
Jung In Kim; Kosuke Tohashi; Shigenori Iwai; Isao Kuraoka
FEBS LETTERS, Dec. 2016, Refereed
Corresponding

Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3 '-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease
Junpei Yamamoto; Chiaki Takahata; Isao Kuraoka; Kouji Hirota; Shigenori Iwai
MOLECULES, Jun. 2016, Refereed

FEN1 participates in repair of the 5 '-phosphotyrosyl terminus of DNA single-strand breaks
Yukiko Kametani; Chiaki Takahata; Takashi Narita; Kiyoji Tanaka; Shigenori Iwai; Isao Kuraoka
CARCINOGENESIS, Jan. 2016, Refereed
Corresponding

Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression
Gemma A. Barron; Marie Goua; Isao Kuraoka; Giovanna Bermano; Shigenori Iwai; Paul Kong Thoo Lin
CHEMICO-BIOLOGICAL INTERACTIONS, Dec. 2015, Refereed

Diversity of endonuclease V: From DNA repair to RNA editing
Isao Kuraoka
Biomolecules, 24 Sep. 2015, Refereed
Corresponding

Epigenetic modifications in DNA could mimic oxidative DNA damage: A double-edged sword
Shinsuke Ito; Isao Kuraoka
DNA REPAIR, Aug. 2015, Refereed
Corresponding

Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex
Chiaki Takahata; Yuji Masuda; Arato Takedachi; Kiyoji Tanaka; Shigenori Iwai; Isao Kuraoka
CARCINOGENESIS, Aug. 2015, Refereed
Corresponding

5-carboxylcytosine G base pairs are mismatch mimicking-base pairs
Toshihiro Shibutani; Shigenori Iwai; Isao Kuraoka
DNA REPAIR, Apr. 2015

The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability
Jean-Hugues Guervilly; Arato Takedachi; Valeria Naim; Sarah Scaglione; Charly Chawhan; Yoann Lovera; Emmanuelle Despras; Isao Kuraoka; Patricia Kannouche; Filippo Rosselli; Pierre-Henri L. Gaillard
MOLECULAR CELL, Jan. 2015, Refereed

The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability
Jean-Hugues Guervilly; Arato Takedachi; Valeria Naim; Sarah Scaglione; Charly Chawhan; Yoann Lovera; Emmanuelle Despras; Isao Kuraoka; Patricia Kannouche; Filippo Rosselli; Pierre-Henri L. Gaillard
MOLECULAR CELL, Jan. 2015, Refereed

SLX4複合体SUMOリガーゼであり複製ストレス応答およびゲノム安定性の維持に寄与する
竹立新人; Jean-Hugues Guervilly; 倉岡功; Pierre-Henri L. Gaillard
ライフサイエンス 新着論文レビュー, Jan. 2015

An in vitro method for detecting genetic toxicity based on inhibition of RNA synthesis by DNA lesions
Yuina Sonohara; Shigenori Iwai; Isao Kuraoka
Genes and Environment, 2015, Refereed
Corresponding

Frequencies of mutagenic translesion DNA synthesis over cisplatin-guanine intra-strand crosslinks in lacZ plasmids propagated in human cells
Yoshihiro Fujikawa; Masanobu Kawanishi; Isao Kuraoka; Takashi Yagi
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, Aug. 2014, Refereed

Fluorescence detection of cellular nucleotide excision repair of damaged DNA
Tatsuya Toga; Isao Kuraoka; Shun Watanabe; Eiji Nakano; Seiji Takeuchi; Chikako Nishigori; Kaoru Sugasawa; Shigenori Iwai
SCIENTIFIC REPORTS, Jul. 2014, Refereed

Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication.
Toshihiro Shibutani; Shinsuke Ito; Mariko Toda; Rie Kanao; Leonard B Collins; Marika Shibata; Miho Urabe; Haruhiko Koseki; Yuji Masuda; James A Swenberg; Chikahide Masutani; Fumio Hanaoka; Shigenori Iwai; Isao Kuraoka
Scientific reports, 09 Jun. 2014, Refereed
Corresponding

An RNA synthesis inhibition assay for detecting toxic substances using click chemistry
Yukiko Kametani; Shigenori Iwai; Isao Kuraoka
JOURNAL OF TOXICOLOGICAL SCIENCES, Apr. 2014, Refereed
Corresponding

A transfection reporter for the prevention of false-negative results in molecular beacon experiments
Tatsuya Toga; Isao Kuraoka; Akira Yasui; Shigenori Iwai
ANALYTICAL BIOCHEMISTRY, Sep. 2013, Refereed

Human endonuclease V is a ribonuclease specific for inosine-containing RNA
Yoko Morita; Toshihiro Shibutani; Nozomi Nakanishi; Kazuko Nishikura; Shigenori Iwai; Isao Kuraoka
NATURE COMMUNICATIONS, Aug. 2013, Refereed
Corresponding

Establishment of a human cell line stably overexpressing mouse Nip45 and characterization of Nip45 subcellular localization
Kohtaro Hashiguchi; Masumi Ozaki; Isao Kuraoka; Hisato Saitoh
Biochemical and Biophysical Research Communications, 04 Jan. 2013, Refereed

Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase: implications for bypass RNA synthesis on oxidative DNA lesions
Nozomi Nakanishi; Atsushi Fukuoh; Dongchon Kang; Shigenori Iwai; Isao Kuraoka
MUTAGENESIS, Jan. 2013, Refereed
Corresponding

Miscoding properties of 8-chloro-2′-deoxyguanosine, a hypochlorous acid-induced DNA adduct, catalysed by human DNA polymerases
Akira Sassa; Nagisa Kamoshita; Tomonari Matsuda; Yuji Ishii; Isao Kuraoka; Takehiko Nohmi; Toshihiro Ohta; Masamitsu Honma; Manabu Yasui
Mutagenesis, Jan. 2013, Refereed

Strand breakage of a (6-4) photoproduct-containing DNA at neutral pH and its repair by the ERCC1-XPF protein complex
Norihito Arichi; Junpei Yamamoto; Chiaki Takahata; Emi Sano; Yuji Masuda; Isao Kuraoka; Shigenori Iwai
ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, Refereed

Effects of 5 ',8-Cyclodeoxyadenosine Triphosphates on DNA Synthesis
Naoto Kamakura; Junpei Yamamoto; Philip J. Brooks; Shigenori Iwai; Isao Kuraoka
CHEMICAL RESEARCH IN TOXICOLOGY, Dec. 2012, Refereed
Corresponding

When and Where Polymerases Encounter DNA Lesions
KURAOKA Isao
Environmental Mutagen Research, 20 May 2012

Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication
Chandanamali Punchihewa; Akira Inoue; Asami Hishiki; Yoshihiro Fujikawa; Michele Connelly; Benjamin Evison; Youming Shao; Richard Heath; Isao Kuraoka; Patrick Rodrigues; Hiroshi Hashimoto; Masanobu Kawanishi; Mamoru Sato; Takashi Yagi; Naoaki Fujii
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2012, Refereed

Xeroderma pigmentosum group F protein binds to Eg5 and is required for proper mitosis: implications for XP-F and XFE
Li Jing Tan; Masafumi Saijo; Isao Kuraoka; Takashi Narita; Chiaki Takahata; Shigenori Iwai; Kiyoji Tanaka
GENES TO CELLS, Mar. 2012, Refereed

A method for detecting genetic toxicity using the RNA synthesis response to DNA damage
Yoko Morita; Shigenori Iwai; Isao Kuraoka
JOURNAL OF TOXICOLOGICAL SCIENCES, Oct. 2011, Refereed
Corresponding

Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex
Katsuyoshi Horibata; Masafumi Saijo; Mui N. Bay; Li Lan; Isao Kuraoka; Philip J. Brooks; Masamitsu Honma; Takehiko Nohmi; Akira Yasui; Kiyoji Tanaka
GENES TO CELLS, Jan. 2011, Refereed

Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana.
Sayo Kashiwagi; Isao Kuraoka; Yoshie Fujiwara; Kenichi Hitomi; Quen J Cheng; Jill O Fuss; David S Shin; Chikahide Masutani; John A Tainer; Fumio Hanaoka; Shigenori Iwai
Journal of nucleic acids, 20 Sep. 2010, Refereed

MMXD, a TFIIH-Independent XPD-MMS19 Protein Complex Involved in Chromosome Segregation
Shinsuke Ito; Li Jing Tan; Daisuke Andoh; Takashi Narita; Mineaki Seki; Yasuhiro Hirano; Keiko Narita; Isao Kuraoka; Yasushi Hiraoka; Kiyoji Tanaka
MOLECULAR CELL, Aug. 2010, Refereed

A non-isotopic assay uses bromouridine and RNA synthesis to detect DNA damage responses.
Mayu Hasegawa; Shigenori Iwai; Isao Kuraoka
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, Jun. 2010, Refereed
Corresponding

Fluorescent probes for the analysis of DNA strand scission in base excision repair
Naoyuki Matsumoto; Tatsuya Toga; Ryosuke Hayashi; Kaoru Sugasawa; Katsuo Katayanagi; Hiroshi Ide; Isao Kuraoka; Shigenori Iwai
NUCLEIC ACIDS RESEARCH, Apr. 2010, Refereed

Polymerization by DNA polymerase eta is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: implications for cytotoxic effects in nucleotide excision repair-negative tumor cells.
Shotaro Chijiwa; Chikahide Masutani; Fumio Hanaoka; Shigenori Iwai; Isao Kuraoka
Carcinogenesis, Mar. 2010, Refereed
Corresponding

DNA conformation-dependent activities of human mitochondrial RNA polymerase
Atsushi Fukuoh; Kippei Ohgaki; Hinako Hatae; Isao Kuraoka; Yoshimasa Aoki; Takeshi Uchiumi; Howard T. Jacobs; Dongchon Kang
GENES TO CELLS, Aug. 2009, Refereed

Expression of an X-family DNA polymerase, pol lambda, in the respiratory epithelium of non-small cell lung cancer patients with habitual smoking.
Ohba T; Kometani T; Shoji F; Yano T; Yoshino I; Taguchi K; Kuraoka I; Oda S; Maehara Y
Mutation research, Jun. 2009, Refereed

Fluorescence detection of the endonuclease III reaction using modified oligonucleotides.
Matsumoto N; Hayashi R; Himoto M; Kuraoka I; Morita S; Hagiwara F; Katayanagi K; Ide H; Iwai S
Nucleic acids symposium series (2004), 2009, Refereed

Effects of DNA Lesions on Transcription Elongation by RNA Polymerases
Kuraoka Isao
Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 20 Aug. 2008

Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair
Isao Kuraoka; Shinsuke Ito; Tadashi Wada; Mika Hayashida; Lily Lee; Masafumi Saijo; Yoshimichi Nakatsu; Megumi Matsumoto; Tsukasa Matsunaga; Hiroshi Handa; Jun Qin; Yoshihiro Nakatani; Kiyoji Tanaka
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2008, Refereed
Lead

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
Tsuyoshi Ikura; Satoshi Tashiro; Akemi Kakino; Hiroki Shima; Naduparambil Jacob; Ravindra Amunugarna; Kristine Yoder; Shunsuke Izumi; Isao Kuraoka; Kiyoji Tanaka; Hiroshi Kimura; Masae Tkura; Shuichi Nishikubo; Takashi Ito; Akihiko Muto; Kiyoshi Miyagawa; Shunichi Takeda; Richard Fishel; Kazuhiko Igarashi; Kenji Kamiya
MOLECULAR AND CELLULAR BIOLOGY, Oct. 2007, Refereed

RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor MIS
Isao Kuraoka; Kyoko Suzuki; Shinsuke Ito; Mika Hayashida; Joan Seah Mei Kwei; Takahisa Ikegami; Hiroshi Handa; Yusaku Nakabeppu; Kiyoji Tanaka
DNA REPAIR, Jun. 2007, Refereed
Lead

Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly
Masanobu Kawanishi; Kazuki Matsukawa; Isao Kuraoka; Takeji Takamura-Enya; Yukari Totsuka; Yasuko Matsumoto; Masahiko Watanabe; Yue Zou; Kiyoji Tanaka; Takashi Sugimura; Keiji Wakabayashi; Takashi Yagi
CHEMICAL RESEARCH IN TOXICOLOGY, Apr. 2007, Refereed

XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: Implications for Cockayne syndrome in XP-G/CS patients
Shinsuke Ito; Isao Kuraoka; Pierre Chymkowitch; Emmanuel Compe; Arato Takedachi; Chie Ishigami; Frederic Coin; Jean-Marc Egly; Kiyoji Tanaka
MOLECULAR CELL, Apr. 2007, Refereed

[DNA repair as a determinant of tumour chemosensitivity].
Oda S; Kuraoka I; Maehara Y
Gan to kagaku ryoho. Cancer & chemotherapy, Mar. 2007, Refereed

CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome
Regina Groisman; Isao Kuraoka; Odile Chevallier; No Gaye gaye; Thierry Magnaldo; Kiyoji Tanaka; Alexei F. Kisselev; Annick Harel-Bellan; Yoshihiro Nakatani
GENES & DEVELOPMENT, Jun. 2006, Refereed

Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality
R Yonemasu; M Minami; Y Nakatsu; M Takeuchi; Kuraoka, I; Y Matsuda; Y Higashi; H Kondoh; K Tanaka
DNA REPAIR, Apr. 2005, Refereed

Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome
K Horibata; Y Iwamoto; Kuraoka, I; NGJ Jaspers; A Kurimasa; M Oshimura; M Ichihashi; K Tanaka
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2004, Refereed

Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCCl, and TFIIH
M Saijo; T Matsuda; Kuraoka, I; K Tanaka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2004, Refereed

Blockage of RNA polymerase II at a cyclobutane pyrimidine dimer and 6-4 photoproduct
JSM Kwei; Kuraoka, I; K Horibata; M Ubukata; E Kobatake; S Iwai; H Handa; K Tanaka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2004, Refereed

A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis
N Inukai; Y Yamaguchi; Kuraoka, I; T Yamada; S Kamijo; J Kato; K Tanaka; H Handa
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2004, Refereed

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
R Groisman; J Polanowska; Kuraoka, I; J Sawada; M Saijo; R Drapkin; AF Kisselev; K Tanaka; Y Nakatani
CELL, May 2003, Refereed

Effects of endogenous DNA base lesions on transcription elongation by mammalian RNA polymerase II - Implications for transcription-coupled DNA repair and transcriptional mutagenesis
Kuraoka, I; M Endou; Y Yamaguchi; T Wada; H Handa; K Tanaka
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2003, Refereed
Lead

Oxygen free radical damage to DNA. Translesion synthesis by human DNA polymerase eta and resistance to exonuclease action at cyclopurine deoxynuelcoside residues.
Kuraoka, I; P Robins; C Masutani; F Hanaoka; D Gasparutto; J Cadet; RD Wood; T Lindahl
JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2001, Refereed
Lead

Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair/recombination nuclease
Kuraoka, I; WR Kobertz; RR Ariza; M Biggerstaff; JM Essigmann; RD Wood
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2000, Refereed
Lead

Removal of oxygen free-radical-induced 5 ',8-purine cyclodeoxynucleosides from DNA by the nucleotide excisicon-repair pathway in human cells
Kuraoka, I; C Bender; A Romieu; J Cadet; RD Wood; T Lindahl
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 2000, Refereed
Lead

RuvAB-mediated branch migration does not involve extensive DNA opening within the RuvB hexamer
H George; Kuraoka, I; DA Nauman; WR Kobertz; RD Wood; SC West
CURRENT BIOLOGY, Jan. 2000, Refereed

DNA damage recognition and nucleotide excision repair in mammalian cells
RD Wood; SJ Araujo; RR Ariza; DP Batty; M Biggerstaff; E Evans; PH Gaillard; D Gunz; B Koberle; Kuraoka, I; JG Moggs; JK Sandall; MKK Shivji
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2000, Refereed

Resonance assignments, solution structure, and backbone dynamics of the DNA- and RPA-binding domain of human repair factor XPA
T Ikegami; Kuraoka, I; M Saijo; N Kodo; Y Kyogoku; K Morikawa; K Tanaka; M Shirakawa
JOURNAL OF BIOCHEMISTRY, Mar. 1999, Refereed

Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA
T Ikegami; Kuraoka, I; M Saijo; N Kodo; Y Kyogoku; K Morikawa; K Tanaka; M Shirakawa
NATURE STRUCTURAL BIOLOGY, Aug. 1998, Refereed

Relationship of the xeroderma pigmentosum group E DNA repair defect to the chromatin and DNA binding proteins UV-DDB and replication protein A
VR Otrin; Kuraoka, I; T Nardo; M McLenigan; APM Eker; M Stefanini; AS Levine; RD Wood
MOLECULAR AND CELLULAR BIOLOGY, Jun. 1998, Refereed

Mutations in the XPD gene leading to Xeroderma pigmentosum symptoms
T Kobayashi; Kuraoka, I; M Saijo; Y Nakatsu; A Tanaka; Y Someda; S Fukuro; K Tanaka
HUMAN MUTATION, 1997, Refereed

Sequential binding of DNA repair proteins RPA and ERCC1 to XPA in vitro
M Saijo; Kuraoka, I; C Masutani; F Hanaoka; K Tanaka
NUCLEIC ACIDS RESEARCH, Dec. 1996, Refereed

Implications of the zinc-finger motif found in the DNA-binding domain of the human XPA protein
EH Morita; T Ohkubo; Kuraoka, I; M Shirakawa; K Tanaka; K Morikawa
GENES TO CELLS, May 1996, Refereed

Identification of a damaged-DNA binding domain of the XPA protein.
Kuraoka I; Morita EH; Saijo M; Matsuda T; Morikawa K; Shirakawa M; Tanaka K
Mutation research, Jan. 1996, Refereed
Lead

ENHANCEMENT OF DAMAGE-SPECIFIC DNA-BINDING OF XPA BY INTERACTION WITH THE ERCC1 DNA-REPAIR PROTEIN
A NAGAI; M SAIJO; KURAOKA, I; T MATSUDA; N KODO; Y NAKATSU; T MIMAKI; M MINO; M BIGGERSTAFF; RD WOOD; A SIJBERS; JHJ HOEIJMAKERS; K TANAKA
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 1995, Refereed

DNA-REPAIR PROTEIN XPA BINDS REPLICATION PROTEIN-A (RPA)
T MATSUDA; M SAIJO; KURAOKA, I; T KOBAYASHI; Y NAKATSU; A NAGAI; T ENJOJI; C MASUTANI; K SUGASAWA; F HANAOKA; A YASUI; K TANAKA
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1995, Refereed

The XPA protein is a zinc metalloprotein with an ability to recognize various kinds of DNA damage.
Asahina H; Kuraoka I; Shirakawa M; Morita EH; Miura N; Miyamoto I; Ohtsuka E; Okada Y; Tanaka K
Mutation research, Nov. 1994, Refereed

RNAに起こる変異シグニチャーを考える
光岡和真、松本朱音、吉田彩、倉岡功
Radiation Biology Research communication, Sep. 2022, Refereed
Corresponding

遺伝情報維持におけるDNAとRNAのコミュニケーション
KAZUKI Matsubara; TAKUTO Kuga; TAKEDACHI Arato; KURAOKA Isao
放射線生物研究, 12 Mar. 2021, Refereed
Corresponding

RATIONAL DESIGN AND DEVELOPMENT OF ANTI-VENOM DRUGS FOR SNAKEBITES BASED ON THE ENDOGENOUS INHIBITORS FROM JAPANESE VIPER
Ayaka Ogura; Yoshifumi Zaitsu; Keizo Hiraishi; Isao Kuraoka; R. Manjunatha Kini; Narumi Shioi Aoki
TOXICON, Mar. 2019

SPECIFICITY OF ENDOGENOUS INHIBITOR FOR THE SNAKE NEUROTOXIN TRIFLIN: INTERACTION AND STRUCTURE ANALYSIS
Narumi Shioi; Takashi Tadokoro; Yaopeng Hu; Lin Hai Kurahara; Keizo Hiraishi; Katsumi Maenaka; Isao Kuraoka; Shigeyuki Terada
TOXICON, Feb. 2019

化学賞 DNA修復機構の発見 : 遺伝情報を安定に維持するためのしくみ (2015年ノーベル賞を読み解く)
倉岡 功
化学 = Chemistry, Dec. 2015

RNAポリメラーゼ転写伸長反応におけるDNA損傷の影響
中西 望; 倉岡 功
放射線生物研究, Mar. 2010

Effects of endogeneous DNA base lesions on transcription elongation by mammalian RNA polymerase II :
KURAOKA Isao; TANAKA kiyoji
Journal of radiation research, 2002

ヒトヌクレチオド除去修復機構によって修復されるDNA酸化損傷とその生物学的意義 : 第12回公開シンポジウム : 活性酸素の分子病態学
KURAOKA Isao; Isao Kuraoka; Institute of Molecular and Cellular Biology Osaka University
Environmental mutagen research communications, 22 Dec. 2001

Identification of a damaged-DNA binding domain of the XPA protein
Kuraoka, I; EH Morita; M Saijo; T Matsuda; K Morikawa; M Shirakawa; K Tanaka
MUTATION RESEARCH-DNA REPAIR, Jan. 1996

NUCLEOTIDE EXCISION-REPAIR DEFECT AND CARCINOGENESIS IN XPA-KNOCKED OUT MICE
K TANAKA; Y NAKATSU; M SAIJO; KURAOKA, I; T MATSUDA; T KOBAYASHI; H MURAI; H NAKANE
JOURNAL OF CELLULAR BIOCHEMISTRY, Mar. 1995

DNA修復 変異と発がんの抑制機構 ヒト色素性乾皮症の分子生物学
倉岡 功; 松田 外志朗; 田中 亀代次
細胞工学, Aug. 1994

Characterization of a DNA-binding domain of the XPA protein : Characterization of a DNA-binding domain of the XPA protein
Kuraoka Isao; Matsuda Tosirou; Saijo Masafumi; Tanaka Kiyoji
Journal of radiation research, 1994

Structure and function of the recombinant XPAC protein with a zinc-finger motif : Structure and function of the recombinant XPAC protein with a zinc-finger motif
Kuraoka Isao; Asahina Hirosi; Shirakawa Masahiko; Morikawa Kotsuke; Tanaka Kiyoji
Journal of radiation research, 1993

新版 放射線医科学 ―生体と放射線・電磁波・超音波
大西 武雄
医療科学社, 10 Nov. 2016
9784860034818

Assaying for the dual incisions of nucleotide excision repair using DNA with a lesion at a specific site.
Shivji MK; Moggs JG; Kuraoka I; Wood RD
2006

Assays for transcription elongation by RNA polymerase II using oligo(dC)-tailed template with single DNA damage.
Kuraoka I; Tanaka K
2006

Dual-incision assays for nucleotide excision repair using DNA with a lesion at a specific site.
Shivji MK; Moggs JG; Kuraoka I; Wood RD
1999

貨幣の謎

ヒトヌクレオチド除去修復で修復される DNA 損傷の探索
倉岡 功
日本環境変異原学会大会第４７回大会, 02 Nov. 2019

ヒトヌクレオチド除去修復によって修復されるDNA損傷の解析
倉岡 功
日本放射線影響学会第61回大会, 07 Nov. 2018

Acetaldehyde is one of the most potent groups of Toxins
Yuina Sonohara; Shigenori Iwai; Isao Kuraoka
The 19th EU-IST Congress, 22 Sep. 2018

An assay to detect DNA-damaging agents that induce NER-able DNA lesions in living human cells
The 12th INTERNATIONAL CONFERENCE & 5th ASIAN CONGRESS ON ENVIRONMENTAL MUTAGENS, 13 Nov. 2017

ヌクレオチド除去修復システムによって修復されるDNA損傷の検出アッセイ
日本環境変異原学会大会プログラム・要旨集, 06 Nov. 2017

New assay to detect DNA-damaging agents in water pollution using DNA enzyme functions.
Yukiko Suematsu; Mika Yukutake; Narumi Shioi; Isao Kuraoka
第5回 水科学ならびに水資源に関する国際会議, 08 Aug. 2017

A study of a novel nucleotide excision-repairable DNA lesion
6th US-Japan DNA repair meeting, 18 May 2017

メチルシトシンの酸化体におけるDNA障害
KURAOKA ISAO
日本環境変異原学会大会プログラム・要旨集, 24 Nov. 2015

ヒトDNAエンドヌクレアーゼVは,イノシンを含むRNAを切断するリボヌクレアーゼである。
KURAOKA ISAO
日本遺伝学会大会プログラム・予稿集, 10 Sep. 2015

ヒトEndonuclease Vにおけるイノシン化RNA切断活性の機能解析
KIM JUNGIN; IWAI SHIGENORI; KURAOKA ISAO
日本RNA学会年会要旨集, 15 Jul. 2015

P-038 RNA合成阻害に基づいたin vitroにおけるDNA損傷検出法の構築(ポスターセッション,ゲノム変異の生成と抑制 : 分子メカニズムの理解からレギュラトリーサイエンスへ)
Sonohara Yuina; Iwai Shigenori; Kuraoka Isao
日本環境変異原学会大会プログラム・要旨集, 2015, 日本環境変異原学会

P-009 ヒトエンドヌクレアーゼVの機能的解析(ポスターセッション,ゲノム変異の生成と抑制 : 分子メカニズムの理解からレギュラトリーサイエンスへ)
KIM JUNGIN; Iwai Shigenori; Kuraoka Isao
日本環境変異原学会大会プログラム・要旨集, 2015, 日本環境変異原学会

S1-4 メチルシトシンの酸化体におけるDNA障害(シンポジウム1 酸化ストレスによる生物影響,ゲノム変異の生成と抑制 : 分子メカニズムの理解からレギュラトリーサイエンスへ)
Kuraoka Isao
日本環境変異原学会大会プログラム・要旨集, 2015, 日本環境変異原学会

ヒトエンドヌクレアーゼVはRNA修復に関与する
KURAOKA ISAO
日本生化学会大会(Web), 2015

5‐メチルシトシンの酸化誘導体における複製システムの障害
KURAOKA ISAO
日本放射線影響学会大会講演要旨集, 17 Sep. 2014

ヒトEndonuclease VはiRNA切断酵素である。
KURAOKA ISAO; IWAI SHIGENORI
日本RNA学会年会要旨集, 23 Jul. 2014

P-079 ヒト細胞抽出液を用いたヌクレオチド除去修復検出系の再構築(ポスターセッション,遺伝毒性と発がん : メカニズムを基軸とするリスク評価)
Sonohara Yuina; Iwai Shigenori; Kuraoka Isao
日本環境変異原学会大会プログラム・要旨集, 2014, 日本環境変異原学会

P-078 Human EEPD1はヌクレアーゼ活性を有する(ポスターセッション,遺伝毒性と発がん : メカニズムを基軸とするリスク評価)
Okada Kenji; Iwai Shigenori; Kuraoka Isao
日本環境変異原学会大会プログラム・要旨集, 2014, 日本環境変異原学会

P-011 イノシンを含むRNAの新たな検出方法の確立(ポスターセッション,遺伝毒性と発がん : メカニズムを基軸とするリスク評価)
Matsuda Yukie; Iwai Shigenori; Kuraoka Isao
日本環境変異原学会大会プログラム・要旨集, 2014, 日本環境変異原学会

O-16 メチルシトシン酸化誘導体が導く複製機構の障害(一般講演3,遺伝毒性と発がん : メカニズムを基軸とするリスク評価)
Kuraoka Isao; Shibutani Toshihiro; Iwai Shigenori
日本環境変異原学会大会プログラム・要旨集, 2014, 日本環境変異原学会

ヒトエンドヌクレアーゼVの機能解析(損傷認識とその応答)
KURAOKA ISAO
日本放射線影響学会大会講演要旨集, 01 Oct. 2013

P-063 Click chemistryを用いた転写反応系用いたDNA損傷検出法の構築(ポスターセッション)
Kametani Yukiko; Iwai Shigenori; Kuraoka Isao
日本環境変異原学会大会プログラム・要旨集, 2013, 日本環境変異原学会

P-075 高度好熱菌由来のエンドヌクレアーゼV(Endo V)の機能解析(ポスターセッション)
Matsuda Yukie; Iwai Shigenori; Kuraoka Isao
日本環境変異原学会大会プログラム・要旨集, 2013, 日本環境変異原学会

P-002 ヒト細胞における3-ニトロベンズアントロンおよびシスプラチンDNA付加体のTLS/変異解析(ポスターセッション,安全・安心のための知的ネットワークの構築:分子生物学的からレギュラトリーサイエンスまで)
Fujikawa Yoshihiro; Higashigaki Yuka; Kawanishi Masanobu; Takamura Takeji; Kuraoka Isao; Yagi Takashi
日本環境変異原学会大会プログラム・要旨集, 2011, 日本環境変異原学会

損傷DNAを鋳型にしたRNA伸長反応と変異の分子メカニズム
KURAOKA ISAO
日本環境変異原学会大会プログラム・要旨集, 29 Oct. 2010

RNAポリメラーゼ転写伸長反応におけるDNA損傷の影響
中西 望; 倉岡 功
放射線生物研究, Mar. 2010, 放射線生物研究会

MMXD:染色体分配に関与するTFIIH非依存性XPDタンパク質複合体
田中亀代次; 伊藤伸介; TAN Li Jing; 安藤大輔; 成田央; 関峰秋; 平野泰弘; 成田圭子; 倉岡功; 平岡泰
生化学, 2010

S1-2 損傷DNAを鋳型にしたRNA伸長反応と変異の分子メカニズム(シンポジウム1:DNA変異からRNAへ-異常RNAとRNAサーベイランス機構-)
Kuraoka Isao
日本環境変異原学会大会プログラム・要旨集, 2010, 日本環境変異原学会

P-033 転写反応を用いたDNA損傷検出系の構築(ポスターセッション)
Morita Yoko; Iwai Shigenori; Kuraoka Isao
日本環境変異原学会大会プログラム・要旨集, 2010, 日本環境変異原学会

転写における色素性乾皮症G群蛋白質の機能
KURAOKA ISAO
日本放射線影響学会大会講演要旨集, 01 Nov. 2009

P-032 DNA修復蛋白質抗体を用いた蛍光抗体法による遺伝毒性評価(ポスターセッション)
Kuraoka Isao; Ojima Yoshihiro; Taya Masahito; Iwai Shigenori
日本環境変異原学会大会プログラム・要旨集, 2009, 日本環境変異原学会

転写およびスプライシングに関与する修復蛋白質XAB2複合体の単離
KURAOKA ISAO; TANAKA KIYOJI
日本放射線影響学会大会講演要旨集, 01 Nov. 2008

P-149 環形動物多毛類生物由来のYファミリーDNAポリメラーゼイータの単離(ポスターセッション)
Kashiwagi Sayo; Kuraoka Isao; Hitomi Kenichi; Fuss Jill; Cheng Quen; Shin Dave S.; Hanaoka Fumio; Tainer John A.; Iwai Shigenori
日本環境変異原学会大会プログラム・要旨集, 2008, 日本環境変異原学会

P-009 ヒトRNAポリメラーゼII転写反応におけるメチル化DNA損傷の影響(ポスターセッション)
Kuraoka Isao; Tanaka Kiyoji
日本環境変異原学会大会プログラム・要旨集, 2008, 日本環境変異原学会

色素性乾皮症G群蛋白質は基本転写因子TFIIH複合体の安定化する
KURAOKA ISAO; ITO SHINSUKE; TAKETATE ARATO; ISHIGAMI TOMOE; TANAKA KIYOJI
日本放射線影響学会大会講演要旨集, 01 Nov. 2007

色素性乾皮症G群蛋白質は基本転写因子TFIIHと複合体を形成する。
KURAOKA ISAO; ITO NOBUSUKE; TAKEDACHI ARATO; TANAKA KIYOJI
家族性腫よう, 15 May 2007

EN-01 ヒト細胞におけるDNA損傷のヌクレオチド除去修復機構に関する研究
KURAOKA Isao
日本環境変異原学会大会プログラム・要旨集, 2007, 日本環境変異原学会

P150 色素性乾皮症G群蛋白質は基本転写因子TFIIHと複合体を形成する
KURAOKA Isao; ITO Shinsuke; TAKEDACHI Arato; ISIGAMI Chie; TANAKA Kiyoji
日本環境変異原学会大会プログラム・要旨集, 2007, 日本環境変異原学会

W2-5 RNAポリメラーゼIIは転写因子SII存在下で酸化DNA損傷8-oxoGを乗り越える(ワークショップ(2) : 損傷乗り越えDNA合成と変異)
Kuraoka Isao; Suzuki Kyoko; Tan Li Jin; Ito Shinsuke; Tanaka Kiyoji
日本環境変異原学会大会プログラム・要旨集, 2006, 日本環境変異原学会

P061 RNAポリメラーゼIIは転写因子SII存在下で酸化DNA損傷8-oxoGを乗り越える(ポスターセッション)
Kuraoka Isao; Suzuki Kyoko; Tan Li Jin; Ito Shinsuke; Tanaka Kiyoji
日本環境変異原学会大会プログラム・要旨集, 2006, 日本環境変異原学会

RNA polymerase IIがDNA損傷に遭遇したときの停止機構の解析
KURAOKA ISAO; SEAH M K; HORIBATA KATSUYOSHI; UBUKATA MANABU; KOBATAKE ERI; IWAI SHIGENORI; HANDA HIROSHI; TANAKA KIYOJI
日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2004

モンシロチョウの蛋白によって生じた損傷を持つDNAの修復・変異・複製
川西優喜; 松川和樹; 高村岳樹; 戸塚ゆ加里; 倉岡功; 田中亀代次; 大橋英治; 大森治夫; ZOU Y
大阪府立大学先端科学研究所放射線総合科学研究センター 平成15年度 放射線施設共同利用報告書, 2004

O6-1 DNA損傷によるRNAポリメラーゼ転写反応障害の考察(一般口演(6) : DNA損傷)
Kuraoka Isao; Horibata Katsuyoshi; Hayashida Mika; Tanaka Kiyoji
日本環境変異原学会大会プログラム・要旨集, 2004, 日本環境変異原学会

ヒトRNAポリメラーゼIIの転写伸長反応におけるDNA損傷の影響
KURAOKA ISAMU; TANAKA KIYOTSUGU
日本放射線影響学会大会講演要旨集, 23 Aug. 2002

ヒトヌクレオチド除去修復機構によって修復されるDNA酸化損傷とその生物学的意義
KURAOKA ISAO
環境変異原研究, 22 Dec. 2001

機能生物化学特論Ⅰ
99 Apr. 2018
福岡大学

生体の化学
99 Apr. 2017

放射化学実験
99 Apr. 2017
福岡大学

機能生物化学実験
99 Apr. 2017
福岡大学

放射化学
99 Apr. 2017
福岡大学

生物化学C
99 Apr. 2017
福岡大学

生物化学B
99 Apr. 2017
福岡大学

化学A
福岡大学

日本生化学会

THE JAPANESE CANCER ASSOCIATION

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

THE JAPAN RADIATION RESEARCH SOCIETY

THE JAPANESE ENVIRONMENTAL MUTAGEN SOCIETY

化学合成ＤＮＡを用いた細胞のミスマッチ修復能の蛍光検出
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Osaka University
01 Apr. 2020 - 31 Mar. 2023

クラスターDNA損傷の構造変化および修復機構の解明
日本学術振興会, 科学研究費助成事業 基盤研究(B), 基盤研究(B)
福岡大学
01 Apr. 2019 - 31 Mar. 2023

転写と共役したDNA鎖切断修復機構の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
01 Apr. 2016 - 31 Mar. 2019

i-RNA切断酵素によるイノシン化RNAの分子制御機構の解析
文部科学省, 科学研究費補助金(挑戦的萌芽研究), 挑戦的萌芽研究
2014 - 2015

トポイソメラーゼ阻害剤により生じたDNA損傷の修復機構の解明
文部科学省, 科学研究費補助金(基盤研究(B)), 基盤研究(B)
2013 - 2015

ヒト細胞の活性状態を規定する工学パラメータの策定と細胞寿命評価
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Osaka University
01 Apr. 2010 - 31 Mar. 2013

なぜマイクロサテライトは変化するのか?
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
National Hospital Organization, Kyushu Cancer Center
2010 - 2012

ミトコンドリアRNAポリメラーゼ転写反応における酸化DNA損傷の影響
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), 基盤研究(C)
Osaka University
2010 - 2012

化学合成DNAセンサーを用いたDNA修復の検出および解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Osaka University
2009 - 2011

転写を阻害するDNA損傷の細胞応答機構とその異常疾患の分子遺伝学的解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S)
Osaka University
2005 - 2009

DNA複製を障害する抗癌剤の作用メカニズムの解明と治療への応用
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Department of Clinical Research, National Hospital Organization National Kyushu Cancer Center
2007 - 2008

マイクロサテライト不安定性はミスマッチ修復異常のみによってもたらされているか?
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Department of Clinical Research, National Hospital Organization National Kyushu Cancer Center
2007 - 2008

転写伸長機構におけるRNAポリメラーゼIIのDNA損傷回避機構の解析
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), 基盤研究(C)
2007 - 2008

停止したRNAポリメラーゼIIに結合するDNA修復因子の検索
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), 基盤研究(C)
2005 - 2006

DNA損傷におけるRNAポリメラーゼII伸長反応の生化学的解析
文部科学省, 科学研究費補助金(若手研究(B)), 若手研究(B)
2003 - 2004

転写とヌクレオチド除去修復機構を共役する新規蛋白質複合体の解析
日本学術振興会, 科学研究費助成事業, 特定領域研究
大阪大学
2000 - 2004

基本転写とDNA修復機構に異常をもつ遺伝疾患の分子遺伝学的解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A)
Osaka University
1999 - 2001

DNAは傷つき、そして癒される。
others
24 Feb. 2018