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Last Updated :2024/03/03

白澤 専二

医学科
教授

プロフィール1989 -1993  九州大学生体防御医学研究所遺伝学部門 博士課程(笹月健彦教授) 1993.3     九州大学生体防御医学研究所遺伝学部門 博士課程修了 医学博士 1993.4 -1993.9 九州大学生体防御医学研究所遺伝学部門 助手 1993.10-1996.3 アメリカワシントン大学ハワードヒューズ医学研究所(Stanley J.Korsmeyer教授)にて博士号取得後、研究員 1996.4 -2001  九州大学生体防御医学研究所遺伝学部門 助手 2001 -2005  国立国際医療センター研究所臨床病理研究部 部長 2006 -現在  福岡大学医学部細胞生物学 教授

研究者情報

■ 学位
  • 医学博士, 九州大学
  • M.D.Ph.D., Kyushu University
■ 研究キーワード
  • 肥満・糖尿病
  • ZFAT遺伝子
  • 血球系細胞分化
  • T細胞分化
  • KRAS遺伝子
  • 大腸癌
  • 発癌の分子機構
■ 研究分野
  • ライフサイエンス, 実験病理学, 実験病理学
  • ライフサイエンス, 医化学, 人類遺伝学
  • ライフサイエンス, 分子生物学, 分子生物学
  • ライフサイエンス, 細胞生物学, 細胞生物学

経歴

■ 経歴
  • 2006年04月
    福岡大学医学部細胞生物学 教授
  • 2001年04月 ー 2006年03月
    国立国際医療センター研究所臨床病理研究部 部長
  • 1996年04月 ー 2001年03月
    九州大学生体防御医学研究所遺伝学部 助手
  • 1993年10月 ー 1996年03月
    米国ワシントン大学医学部ハワードヒューズ医学研究所 ポスドク
  • 1987年04月 ー 1989年03月
    九州大学医学部附属病院 研修医
■ 学歴
  • 九州大学, 医学部
  • 九州大学大学院, 医学系研究科

研究活動情報

■ 論文
  • Inhibitory Effect of Pyra–Metho–Carnil on Cancer Spheroid Growth Through Decrease in Glycolysis-associated Molecules
    KAZUMASA YOSHIDA; KENSUKE NISHI; SHUHEI ISHIKURA; TAICHI MATSUMOTO; KAZUHIKO NAKABAYASHI; RYO YAZAKI; TAKASHI OHSHIMA; MASAHIKO SUENAGA; SENJI SHIRASAWA; TOSHIYUKI TSUNODA
    Anticancer Research, 2023年07月26日
  • Death domain-associated protein DAXX regulates non-coding RNA transcription at the centromere through the transcription regulator ZFAT.
    Shuhei Ishikura; Kazumasa Yoshida; Toshiyuki Tsunoda; Senji Shirasawa
    The Journal of biological chemistry, 2022年09月23日
  • Cryptotanshinone suppresses tumorigenesis by inhibiting lipogenesis and promoting reactive oxygen species production in KRAS‑activated pancreatic cancer cells.
    Tokio Terado; Chul Jang Kim; Akiyo Ushio; Kahori Minami; Yukihiro Tambe; Susumu Kageyama; Akihiro Kawauchi; Toshiyuki Tsunoda; Senji Shirasawa; Hiroyuki Tanaka; Hirokazu Inoue
    International journal of oncology, 2022年09月
  • Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis.
    Kensuke Nishi; Shohei Yoshimoto; Soichiro Nishi; Tatsuro Nishi; Ryushiro Nishi; Takayuki Tanaka; Toshiyuki Tsunoda; Kazuaki Imai; Hiroaki Tanaka; Osamu Hotta; Ayaki Tanaka; Kenji Hiromatsu; Senji Shirasawa; Takashi Nakagawa; Takafumi Yamano
    International journal of molecular sciences, 2022年08月16日
  • Standardized Methods Using EUS-guided Fine-needle Biopsy and a Minimal Medium Creates Three Pancreatic Cancer Organoids.
    Yusuke Ishida; Toshiyuki Tsunoda; Yoshihiro Hamada; Naoaki Tsuchiya; Takehiko Koga; Takanori Kitaguchi; Keisuke Matsumoto; Shinji Matsumoto; Takahide Sasaki; Ryo Nakashima; Fuminori Ishii; Masatoshi Kajiwara; Senji Shirasawa; Suguru Hasegawa; Fumihito Hirai
    Anticancer research, 2022年08月
  • Cancer Spheroid Proliferation Is Suppressed by a Novel Low-toxicity Compound, Pyra-Metho-Carnil, in a Context-independent Manner.
    Kazumasa Yoshida; Kensuke Nishi; Shuhei Ishikura; Kazuhiko Nakabayashi; Ryo Yazaki; Takashi Ohshima; Masahiko Suenaga; Senji Shirasawa; Toshiyuki Tsunoda
    Anticancer research, 2022年08月
  • Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.
    Kensuke Nishi; Shohei Yoshimoto; Soichiro Nishi; Tatsuro Nishi; Ryushiro Nishi; Toshiyuki Tsunoda; Hiromitsu Morita; Hiroaki Tanaka; Osamu Hotta; Susumu Yasumasu; Kenji Hiromatsu; Senji Shirasawa; Takashi Nakagawa; Takafumi Yamano
    In vivo (Athens, Greece), 2022年
  • Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment.
    Imai K; Yamano T; Nishi S; Nishi R; Nishi T; Tanaka H; Tsunoda T; Yoshimoto S; Tanaka A; Hiromatsu K; Shirasawa S; Nakagawa T; Nishi K
    Viruses, 2022年, 査読有り, 通常論文
  • Fibroblast-Induced Paradoxical PI3K Pathway Activation in PTEN-Competent Colorectal Cancer: Implications for Therapeutic PI3K/mTOR Inhibition.
    Conciatori F; Salvati E; Ciuffreda L; Shirasawa S; Falcone I; Cognetti F; Ferretti G; Zeuli M; Del Bufalo D; Bazzichetto C; Milella M
    Front. Oncol., 2022年, 査読有り, 通常論文
  • The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes.
    Ishikura S; Nagai M; Tsunoda T; Nishi K; Tanaka Y; Koyanagi M; Shirasawa S
    J. Cell Biochem., 2021年, 査読有り, 通常論文
  • Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.
    Hanada K; Kawada K; Nishikawa G; Toda K; Maekawa H; Nishikawa Y; Masui H; Hirata W; Okamoto M; Kiyasu Y; Honma S; Ogawa R; Mizuno R; Itatani Y; Miyoshi H; Sasazuki T; Shirasawa S; Taketo MM; Obama K; Sakai Y
    Cancer Lett., 2021年, 査読有り, 通常論文
  • Effects of Aspergillus fumigatus Conidia on Apoptosis and Proliferation in an In Vitro Model of the Lung Microenvironment.
    Kushima H; Tsunoda T; Matsumoto T; Kinoshita Y; Izumikawa K; Shirasawa S; Fujita M; Ishii H
    Microorganisms, 2021年, 査読有り, 通常論文
  • Growth Suppression of Cancer Spheroids With Mutated KRAS by Low-toxicity Compounds from Natural Products.
    Hashimoto S; Nagai M; Nishi K; Ishikura S; Nakabayashi K; Yazaki R; Ohshima T; Suenaga M; Shirasawa S; Tsunoda T
    Anticancer Res., 2021年, 査読有り, 通常論文
  • Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1.
    Kandasamy P; Zlobec I; Nydegger DT; Giménez JP; Bhardwaj R; Shirasawa S; Tsunoda T; Hediger MA
    Mol. Oncol., 2021年, 査読有り, 通常論文
  • CENP-B promotes the centromeric localization of ZFAT to control transcription of non-coding RNA.
    Ishikura S; Yoshida K; Hashimoto S; Nakabayashi K; Tsunoda T; Shirasawa S
    J. Biol. Chem., 2021年, 査読有り, 通常論文
  • Mutant KRAS Promotes NKG2D+ T Cell Infiltration and CD155 Dependent Immune Evasion.
    Nishi K; Ishikura S; Umebayashi M; Morisaki T; Inozume T; Kinugasa T; Aoki M; Nimura S; Swain A; Yoshida Y; Hasegawa S; Nabeshima K; Sakata T; Shirasawa S; Tsunoda T
    Anticancer Res., 2020年, 査読有り, 通常論文
  • MK615 Suppresses Hypoxia Tolerance by Up-regulation of E-cadherin in Colorectal Cancer Cells With Mutant KRAS.
    Nishi K; Tsunoda T; Uchida Y; Sueta T; Sawatsubashi M; Yamano T; Hashiguchi Y; Swain A; Shirasawa S; Sakata T
    Anticancer Res., 2020年, 査読有り, 通常論文
  • In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
    Wong CC; Xu J; Bian X; Wu JL; Kang W; Qian Y; Li W; Chen H; Gou H; Liu D; Yat Luk ST; Zhou Q; Ji F; Chan LS; Shirasawa S; Sung JJ; Yu J
    Gastroenterology, 2020年, 査読有り, 通常論文
  • Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90.
    Ernst A; Hennel R; Krombach J; Kapfhammer H; Brix N; Zuchtriegel G; Uhl B; Reichel CA; Frey B; Gaipl US; Winssinger N; Shirasawa S; Sasazuki T; Sperandio M; Belka C; Lauber K
    Front. Oncol., 2020年, 査読有り, 通常論文
  • ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B-H4K8ac-BRD4 axis.
    Ishikura S; Nakabayashi K; Nagai M; Tsunoda T; Shirasawa S
    Nucleic Acids Res., 2020年, 査読有り, 通常論文
  • BRAF status modulates Interelukin-8 expression through a CHOP-dependent mechanism in colorectal cancer.
    Conciatori F; Bazzichetto C; Amoreo CA; Sperduti I; Donzelli S; Diodoro MG; Buglioni S; Falcone I; Shirasawa S; Blandino G; Ferretti G; Cognetti F; Milella M; Ciuffreda L
    Commun. Biol., 2020年, 査読有り, 通常論文
  • Next Generation Lipophilic Bisphosphonate Shows Antitumor Effect in Colorectal Cancer In Vitro and In Vivo.
    Baranyi M; Rittler D; Molnár E; Shirasawa S; Jalsovszky I; Varga IK; Hegedűs L; Németh A; Dank M; Aigner C; Tóvári J; Tímár J; Hegedűs B; Garay T
    Pathol. Oncol. Res., 2020年, 査読有り, 通常論文
  • Targeting the KRAS oncogene: Synthesis, physicochemical and biological evaluation of novel G-quadruplex DNA binders.
    D'Aria F; D'Amore VM; Leva FSD; Amato J; Caterino M; Russomanno P; Salerno S; Barresi E; De Leo M; Marini AM; Taliani S; Da Settimo F; Salgado GF; Pompili L; Zizza P; Shirasawa S; Novellino E; Biroccio A; Marinelli L; Giancola C
    Eur. J. Pharm. Sci., 2020年, 査読有り, 通常論文
  • A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells.
    Yuuga Sawata; Taiji Matsukawa; Satoshi Doi; Toshiyuki Tsunoda; Nagisa Arikawa; Natsumi Matsunaga; Koichiro Ohnuki; Senji Shirasawa; Yojiro Kotake
    Molecular and cellular biochemistry, 2019年12月
  • A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells.
    Sawata Y; Matsukawa T; Doi S; Tsunoda T; Arikawa N; Matsunaga N; Ohnuki K; Shirasawa S; Kotake Y
    2019年12月, 査読有り, 通常論文
  • Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation.
    Charitou T; Srihari S; Lynn MA; Jarboui MA; Fasterius E; Moldovan M; Shirasawa S; Tsunoda T; Ueffing M; Xie J; Xin J; Wang X; Proud CG; Boldt K; Al-Khalili Szigyarto C; Kolch W; Lynn DJ
    Br. J. Cancer, 2019年, 査読有り, 通常論文
  • Zfat is indispensable for the development of erythroid cells in the fetal liver.
    Doi K; Tsunoda T; Koyanagi M; Tanaka Y; Yamano S; Fujikane A; Nishi K; Ishikura S; Shirasawa S
    Anticancer Res., 2019年, 査読有り, 通常論文
  • Acquisition of resistance to vemurafenib leads to interleukin-10 production through an aberrant activation of Akt in a melanoma cell line.
    Takashi Inozume; Toshiyuki Tsunoda; Takashi Morisaki; Kazutoshi Harada; Seiji Shirasawa; Tatsuyoshi Kawamura
    The Journal of dermatology, 2018年12月, 査読有り, 通常論文
  • Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells
    Byong Hoon Yoo; Iman Aftab Khan; Ananda Koomson; Pramod Gowda; Takehiko Sasazuki; Senji Shirasawa; Shashi Gujar; Kirill V. Rosen
    Autophagy, 2018年01月02日, 査読有り, 通常論文
  • The long noncoding RNA OIP5-AS1 is involved in the regulation of cell proliferation
    Madoka Naemura; Masahide Kuroki; Toshiyuki Tsunoda; Nagisa Arikawa; Yuuga Sawata; Senji Shirasawa; Yojiro Kotake
    Anticancer Research, 2018年01月01日, 査読有り, 通常論文
  • A novel resveratrol derivative selectively inhibits the proliferation of colorectal cancer cells with KRAS mutation.
    Okamoto H; Matsukawa T; Doi S; Tsunoda T; Sawata Y; Naemura M; Ohnuki K; Shirasawa S; Kotake Y
    Mol. Cell Biochem., 2018年, 査読有り, 通常論文
  • Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models.
    Del Curatolo A; Conciatori F; Cesta Incani U; Bazzichetto C; Falcone I; Corbo V; D'Agosto S; Eramo A; Sette G; Sperduti I; De Luca T; Marabese M; Shirasawa S; De Maria R; Scarpa A; Broggini M; Del Bufalo D; Cognetti F; Milella M; Ciuffreda L
    J. Exp. Clin. Cancer Res., 2018年, 査読有り, 通常論文
  • Growth Suppression of Human Colorectal Cancer Cells with Mutated KRAS by 3-Deaza-cytarabine in 3D Floating Culture.
    Luo H; Nishi K; Ishikura S; Swain A; Morishige N; Yazaki R; Ohshima T; Shirasawa S; Tsunoda T
    Anticancer Res., 2018年, 査読有り, 通常論文
  • In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer.
    Wei R; Wong JPC; Lyu P; Xi X; Tong O; Zhang SD; Yuen HF; Shirasawa S; Kwok HF
    J. Cell Mol. Med., 2018年, 査読有り, 通常論文
  • Zfat expression in ZsGreen reporter gene knock-in mice: Implications for a novel function of Zfat in definitive erythropoiesis.
    Tsunoda T; Doi K; Ishikura S; Luo H; Nishi K; Matsuzaki H; Koyanagi M; Tanaka Y; Okamura T; Shirasawa S
    Int. J. Mol. Med., 2018年, 査読有り, 通常論文
  • MACC1 regulates Fas mediated apoptosis through STAT1/3-Mcl-1 signaling in solid cancers
    Harikrishnan Radhakrishnan; Katharina Ilm; Wolfgang Walther; Senji Shirasawa; Takehiko Sasazuki; Peter T. Daniel; Bernhard Gillissen; Ulrike Stein
    CANCER LETTERS, 2017年09月, 査読有り, 通常論文
  • Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS
    Kensuke Nishi; Hao Luo; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Lauren Wills; George S. Baillie; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
    ANTICANCER RESEARCH, 2017年07月, 査読有り, 通常論文
  • An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.
    Kensuke Nishi; Hao Luo; Kazuhiko Nakabayashi; Keiko Doi; Shuhei Ishikura; Yuri Iwaihara; Yasuhiro Yoshida; Kumpei Tanisawa; Tomio Arai; Seijiro Mori; Motoji Sawabe; Masaaki Muramatsu; Masashi Tanaka; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
    Anticancer research, 2017年07月, 査読有り, 通常論文
  • MEK162 Enhances Antitumor Activity of 5-Fluorouracil and Trifluridine in KRAS-mutated Human Colorectal Cancer Cell Lines
    Jun Gong; Yuan Chen; Lixin Yang; Raju Pillai; Senji Shirasawa; Marwan Fakih
    ANTICANCER RESEARCH, 2017年06月, 査読有り, 通常論文
  • Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae
    Murugan Kalimutho; Amanda L. Bain; Bipasha Mukherjee; Purba Nag; Devathri M. Nanayakkara; Sarah K. Harten; Janelle L. Harris; Goutham N. Subramanian; Debottam Sinha; Senji Shirasawa; Sriganesh Srihari; Sandeep Burma; Kum Kum Khanna
    MOLECULAR ONCOLOGY, 2017年05月, 査読有り, 通常論文
  • Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1
    Hirotada Tajiri; Takehito Uruno; Takahiro Shirai; Daisuke Takaya; Shigeki Matsunaga; Daiki Setoyama; Mayuki Watanabe; Mutsuko Kukimoto-Niino; Kounosuke Oisaki; Miho Ushijima; Fumiyuki Sanematsu; Teruki Honma; Takaho Terada; Eiji Oki; Senji Shirasawa; Yoshihiko Maehara; Dongchon Kang; Jean-Francois Cote; Shigeyuki Yokoyama; Motomu Kanai; Yoshinori Fukui
    CELL REPORTS, 2017年05月, 査読有り, 通常論文
  • ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line.
    Nishi K. Iwaihara; Y. Tsunoda; T. Doi; K; Sakata; T. Shirasawa; S. Ishikura S
    Cell Death Dis., 2017年, 査読有り, 通常論文
  • Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells
    Shuhei Ishikura; Toshiyuki Tsunoda; Kazuhiko Nakabayashi; Keiko Doi; Midori Koyanagi; Keiko Hayashi; Tomoko Kawai; Yoko Tanaka; Yuri Iwaihara; Hao Luo; Kensuke Nishi; Tadashi Okamura; Senji Shirasawa
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2016年11月, 査読有り, 通常論文
  • Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase
    Kosuke Toda; Kenji Kawada; Masayoshi Iwamoto; Susumu Inamoto; Takehiko Sasazuki; Senji Shirasawa; Suguru Hasegawa; Yoshiharu Sakai
    NEOPLASIA, 2016年11月, 査読有り, 通常論文
  • Oncogenic Ras influences the expression of multiple lncRNAs
    Yojiro Kotake; Madoka Naemura; Kyoko Kitagawa; Hiroyuki Niida; Toshiyuki Tsunoda; Senji Shirasawa; Masatoshi Kitagawa
    CYTOTECHNOLOGY, 2016年08月, 査読有り, 通常論文
  • Oncogenic Ras influences the expression of multiple lncRNAs
    Yojiro Kotake; Madoka Naemura; Kyoko Kitagawa; Hiroyuki Niida; Toshiyuki Tsunoda; Senji Shirasawa; Masatoshi Kitagawa
    CYTOTECHNOLOGY, 2016年08月, 査読有り, 通常論文
  • The Nuclear Zinc Finger Protein Zfat Maintains Fox01 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway
    Shuhei Ishikura; Yuri Iwaihara; Yoko Tanaka; Hao Luo; Kensuke Nishi; Keiko Doi; Midori Koyanagi; Tadashi Okamura; Toshiyuki Tsunoda; Senji Shirasawa
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2016年07月, 査読有り, 通常論文
  • Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells
    Hao Luo; Masayo Umebayashi; Keiko Doi; Takashi Morisaki; Senji Shirasawa; Toshiyuki Tsunoda
    ANTICANCER RESEARCH, 2016年07月, 査読有り, 通常論文
  • DBA Lectin Binds to Highly Proliferative Mouse Erythroleukemia Cells
    Anthony Swain; Kasem Kulkeaw; Yuka Tanaka; Yoichi Nakanishi; Senji Shirasawa; Daisuke Sugiyama
    ANTICANCER RESEARCH, 2016年07月, 査読有り, 通常論文
  • In Hyperthermia Increased ERK and WNT Signaling Suppress Colorectal Cancer Cell Growth
    Michael Bordonaro; Senji Shirasawa; Darina L. Lazarova
    CANCERS, 2016年05月, 査読有り, 通常論文
  • Synthesis of New Congeners of 1-methyl-3-aminoisoquinolines, Evaluation of Their Cytotoxic Activity, In Silico and In Vitro Study of Their Molecular Targets as PDE4B
    Gennady B. Lapa; Toshiyuki Tsunoda; Senji Shirasawa; Maria A. Baryshnikova; Gregory G. Evseev; Daria A. Afanasyeva; Elena A. Chigorina
    CHEMICAL BIOLOGY & DRUG DESIGN, 2016年04月, 査読有り, 通常論文
  • BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells
    Maria Goulielmaki; Evangelos Koustas; Eirini Moysidou; Margarita Vlassi; Takehiko Sasazuki; Senji Shirasawa; George Zografos; Eftychia Oikonomou; Alexander Pintzas
    ONCOTARGET, 2016年02月, 査読有り, 通常論文
  • EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer
    Philip D. Dunne; Sonali Dasgupta; Jaine K. Blayney; Darragh G. McArt; Keara L. Redmond; Jessica-Anne Weir; Conor A. Bradley; Takehiko Sasazuki; Senji Shirasawa; Tingting Wang; Supriya Srivastava; Chee Wee Ong; Ken Arthur; Manuel Salto-Tellez; Richard H. Wilson; Patrick G. Johnston; Sandra Van Schaeybroeck
    CLINICAL CANCER RESEARCH, 2016年01月, 査読有り, 通常論文
  • ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture
    Madoka Naemura; Toshiyuki Tsunoda; Yasutoshi Inoue; Haruna Okamoto; Senji Shirasawa; Yojiro Kotake
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2016年01月, 査読有り, 通常論文
  • Embryonic Hematopoietic Progenitor Cells Reside in Muscle before Bone Marrow Hematopoiesis
    Yuka Tanaka; Tomoko Inoue-Yokoo; Kasem Kulkeaw; Chiyo Yanagi-Mizuochi; Senji Shirasawa; Yoichi Nakanishi; Daisuke Sugiyama
    PLOS ONE, 2015年09月, 査読有り, 通常論文
  • Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells
    Byong Hoon Yoo; Anna Zagryazhskaya; Yongling Li; Ananda Koomson; Iman Aftab Khan; Takehiko Sasazuki; Senji Shirasawa; Kirill V Rosen
    AUTOPHAGY, 2015年08月, 査読有り, 通常論文
  • Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells
    Yuri Iwaihara; Shuhei Ishikura; Keiko Doi; Toshiyuki Tsunoda; Takahiro Fujimoto; Tadashi Okamura; Senji Shirasawa
    ANTICANCER RESEARCH, 2015年08月, 査読有り, 通常論文
  • Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules
    Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Hiromasa Hidesima; Hao Luo; Yumiko Hirose; Senji Shirasawa
    ANTICANCER RESEARCH, 2015年08月, 査読有り, 通常論文
  • Apoptosis-inducing Factor, Mitochondrion-associated 2, Regulates Klf1 in a Mouse Erythroleukemia Cell Line
    Naoko Kojima; Yuka Tanaka; Kasem Kulkeaw; Yoichi Nakanishi; Senji Shirasawa; Daisuke Sugiyama
    ANTICANCER RESEARCH, 2015年08月, 査読有り, 通常論文
  • Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT
    Naoya Tochio; Takashi Umehara; Kazuhiko Nakabayashi; Misao Yoneyama; Kengo Tsuda; Mikako Shirouzu; Seizo Koshiba; Satoru Watanabe; Takanori Kigawa; Takehiko Sasazuki; Senji Shirasawa; Shigeyuki Yokoyama
    Journal of Structural and Functional Genomics, 2015年06月15日, 査読有り, 通常論文
  • Zfat-Deficient CD4(+)CD8(+) Double-Positive Thymocytes Are Susceptible to Apoptosis With Deregulated Activation of p38 and JNK
    Shuhei Ishikura; Masahiro Ogawa; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Yoko Tanaka; Toshiyuki Tsunoda; Hiromasa Hideshima; Tadashi Okamura; Senji Shirasawa
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2015年01月, 査読有り, 通常論文
  • Regulation of F-18-FDG Accumulation in Colorectal Cancer Cells with Mutated KRAS
    Masayoshi Iwamoto; Kenji Kawada; Yuji Nakamoto; Yoshiro Itatani; Susumu Inamoto; Kosuke Toda; Hiroyuki Kimura; Takehiko Sasazuki; Senji Shirasawa; Hiroaki Okuyama; Masahiro Inoue; Suguru Hasegawa; Kaori Togashi; Yoshiharu Sakai
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  • Competition between human cells by entosis
    Qiang Sun; Tianzhi Luo; Yixin Ren; Oliver Florey; Senji Shirasawa; Takehiko Sasazuki; Douglas N. Robinson; Michael Overholtzer
    CELL RESEARCH, 2014年11月, 査読有り, 通常論文
  • The Roles of ZFAT in Thymocyte Differentiation and Homeostasis of Peripheral Naive T-Cells
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    ANTICANCER RESEARCH, 2014年08月, 査読有り, 通常論文
  • Resveratrol Induces Luminal Apoptosis of Human Colorectal Cancer HCT116 Cells in Three-dimensional Culture
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    ANTICANCER RESEARCH, 2014年08月, 査読有り, 通常論文
  • Dok2 Likely Down-regulates Klf1 in Mouse Erythroleukemia Cells
    Yuka Tanaka; Kasem Kulkeaw; Tomoko Inoue; Keai Sinn Tan; Yoichi Nakanishi; Senji Shirasawa; Daisuke Sugiyama
    ANTICANCER RESEARCH, 2014年08月, 査読有り, 通常論文
  • ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer
    Sandra Van Schaeybroeck; Murugan Kalimutho; Philip D. Dunne; Robbie Carson; Wendy Allen; Puthen V. Jithesh; Keara L. Redmond; Takehiko Sasazuki; Senji Shirasawa; Jaine Blayney; Paolo Michieli; Cathy Fenning; Heinz-Josef Lenz; Mark Lawler; Daniel B. Longley; Patrick G. Johnston
    CELL REPORTS, 2014年06月, 査読有り, 通常論文
  • KRAS mutation confers resistance to antibody-dependent cellular cytotoxicity of cetuximab against human colorectal cancer cells
    Yusuke Nakadate; Yasuo Kodera; Yuka Kitamura; Senji Shirasawa; Taro Tachibana; Tomohide Tamura; Fumiaki Koizumi
    INTERNATIONAL JOURNAL OF CANCER, 2014年05月, 査読有り, 通常論文
  • Adrenomedullin is a therapeutic target in colorectal cancer
    Liangjing Wang; Manish Gala; Masayoshi Yamamoto; Maria S. Pino; Hirotoshi Kikuchi; Daniel S. Shue; Senji Shirasawa; Thomas R. Austin; Maureen P. Lynch; Bo R. Rueda; Lawrence R. Zukerberg; Daniel C. Chung
    INTERNATIONAL JOURNAL OF CANCER, 2014年05月, 査読有り, 通常論文
  • p120RasGAP Is a Mediator of Rho Pathway Activation and Tumorigenicity in the DLD1 Colorectal Cancer Cell Line
    Shawna L. Organ; Josephine Hai; Nikolina Radulovich; Christopher B. Marshall; Lisa Leung; Takehiko Sasazuki; Senji Shirasawa; Chang-Qi Zhu; Roya Navab; Mitsuhiko Ikura; Ming-Sound Tsao
    PLOS ONE, 2014年01月, 査読有り, 通常論文
  • Zfat-Deficiency Results in a Loss of CD3ζ Phosphorylation with Dysregulation of ERK and Egr Activities Leading to Impaired Positive Selection
    Masahiro Ogawa; Tadashi Okamura; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yoko Tanaka; Takeharu Ota; Kunihiro Hayakawa; Harumi Suzuki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
    PLoS ONE, 2013年10月03日, 査読有り, 通常論文
  • Roles of ZFAT in Haematopoiesis, Angiogenesis and Cancer Development
    Toshiyuki Tsunoda; Senji Shirasawa
    ANTICANCER RESEARCH, 2013年07月, 査読有り, 通常論文
  • Molecular Hierarchy of Heparin-Binding EGF-like Growth Factor-Regulated Angiogenesis in Triple-Negative Breast Cancer
    Fusanori Yotsumoto; Eriko Tokunaga; Eiji Oki; Yoshihiko Maehara; Hiromi Yamada; Kyoko Nakajima; Sung Ouk Nam; Kohei Miyata; Midori Koyanagi; Keiko Doi; Senji Shirasawa; Masahide Kuroki; Shingo Miyamoto
    MOLECULAR CANCER RESEARCH, 2013年05月, 査読有り, 通常論文
  • MDR1 C3435T Polymorphism and Interaction with Environmental Factors in Risk of Parkinson's Disease: A Case-control Study in Japan
    Chikako Kiyohara; Yoshihiro Miyake; Midori Koyanagi; Takahiro Fujimoto; Senji Shirasawa; Keiko Tanaka; Wakaba Fukushima; Satoshi Sasaki; Yoshio Tsuboi; Tatsuo Yamada; Tomoko Oeda; Hiroyuki Shimada; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yishio Hirota; Masaki Nagai
    DRUG METABOLISM AND PHARMACOKINETICS, 2013年04月, 査読有り, 通常論文
  • Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux
    Hiroshi Matsuzaki; Takahiro Fujimoto; Masatoshi Tanaka; Senji Shirasawa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013年04月, 査読有り, 通常論文
  • Tespa1 protein is phosphorylated in response to store-operated calcium entry
    Takahiro Fujimoto; Hiroshi Matsuzaki; Masatoshi Tanaka; Senji Shirasawa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013年04月, 査読有り, 通常論文
  • Identification of Mutant K-Ras-dependent Phenotypes Using a Panel of Isogenic Cell Lines
    Steffan Vartanian; Carolyn Bentley; Matthew J. Brauer; Li Li; Senji Shirasawa; Takehiko Sasazuki; Jung-Sik Kim; Pete Haverty; Eric Stawiski; Zora Modrusan; Todd Waldman; David Stokoe
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013年01月, 査読有り, 通常論文
  • Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney
    Takahiro Fujimoto; Senji Shirasawa
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2012年12月, 査読有り, 通常論文
  • High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells
    Tomohiro Kozako; Akiyoshi Aikawa; Teruhisa Shoji; Takahiro Fujimoto; Makoto Yoshimitsu; Senji Shirasawa; Hiroaki Tanaka; Shin-ichiro Honda; Hiroshi Shimeno; Naomichi Arima; Shinji Soeda
    INTERNATIONAL JOURNAL OF CANCER, 2012年11月, 査読有り, 通常論文
  • Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA
    Pat Gulhati; Yekaterina Y. Zaytseva; Joseph D. Valentino; Payton D. Stevens; Ji Tae Kim; Takehiko Sasazuki; Senji Shirasawa; Eun Y. Lee; Heidi L. Weiss; Jianli Dong; Tianyan Gao; B. Mark Evers
    CARCINOGENESIS, 2012年09月, 査読有り, 通常論文
  • Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation
    Georgia Ikonomou; Vassiliki Kostourou; Senji Shirasawa; Takehiko Sasazuki; Martina Samiotaki; George Panayotou
    JOURNAL OF PROTEOMICS, 2012年09月, 査読有り, 通常論文
  • Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells
    Hiu-Fung Yuen; Olga Abramczyk; Grant Montgomery; Ka-Kui Chan; Yu-Han Huang; Takehiko Sasazuki; Senji Shirasawa; Srivastava Gopesh; Kwok-Wah Chan; Dean Fennell; Pasi Janne; Mohamed El-Tanani; James T. Murray
    BIOSCIENCE REPORTS, 2012年08月, 査読有り, 通常論文
  • ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response
    Keiko Doi; Takahiro Fujimoto; Tadashi Okamura; Masahiro Ogawa; Yoko Tanaka; Yasumasa Mototani; Motohito Goto; Takeharu Ota; Hiroshi Matsuzaki; Masahide Kuroki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012年08月, 査読有り, 通常論文
  • Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model
    Toshiyuki Tsunoda; Takeharu Ota; Takahiro Fujimoto; Keiko Doi; Yoko Tanaka; Yasuhiro Yoshida; Masahiro Ogawa; Hiroshi Matsuzaki; Masato Hamabashiri; Darren R. Tyson; Masahide Kuroki; Shingo Miyamoto; Senji Shirasawa
    MOLECULAR CANCER, 2012年07月, 査読有り, 通常論文
  • KRAS Up-regulates the Expression of miR-181a, miR-200c and miR-210 in a Three-dimensional-specific Manner in DLD-1 Colorectal Cancer Cells
    Takeharu Ota; Keiko Doi; Takahiro Fujimoto; Yoko Tanaka; Masahiro Ogawa; Hiroshi Matsuzaki; Masahide Kuroki; Shingo Miyamoto; Senji Shirasawa; Toshiyuki Tsunoda
    ANTICANCER RESEARCH, 2012年06月, 査読有り, 通常論文
  • ALPK2 is Crucial for Luminal Apoptosis and DNA Repair-related Gene Expression in a Three-dimensional Colonic-crypt Model
    Yasuhiro Yoshida; Toshiyuki Tsunoda; Keiko Doi; Takahiro Fujimoto; Yoko Tanaka; Takeharu Ota; Masahiro Ogawa; Hiroshi Matsuzaki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
    ANTICANCER RESEARCH, 2012年06月, 査読有り, 通常論文
  • Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling
    Ning Liu; Masaki Matsumoto; Kyoko Kitagawa; Yojiro Kotake; Sayuri Suzuki; Senji Shirasawa; Keiichi I. Nakayama; Makoto Nakanishi; Hiroyuki Niida; Masatoshi Kitagawa
    EMBO JOURNAL, 2012年05月, 査読有り, 通常論文
  • Important Role of Epiregulin in Inflammatory Responses during Corneal Epithelial Wound Healing
    Yuan Zhang; Takeshi Kobayashi; Yasuhito Hayashi; Ryuji Yoshioka; Atsushi Shiraishi; Senji Shirasawa; Shigeki Higashiyama; Yuichi Ohashi
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012年04月, 査読有り, 通常論文
  • Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes
    Hiroshi Matsuzaki; Takahiro Fujimoto; Takeharu Ota; Masahiro Ogawa; Toshiyuki Tsunoda; Keiko Doi; Masato Hamabashiri; Masatoshi Tanaka; Senji Shirasawa
    FEBS OPEN BIO, 2012年, 査読有り, 通常論文
  • Oncogenic ras-induced Down-regulation of Pro-apoptotic Protease Caspase-2 Is Required for Malignant Transformation of Intestinal Epithelial Cells
    Byong Hoon Yoo; Yanfei Wang; Mete Erdogan; Takehiko Sasazuki; Senji Shirasawa; Laurent Corcos; Kanaga Sabapathy; Kirill V. Rosen
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011年11月, 査読有り, 通常論文
  • Identification of independent risk loci for Graves' disease within the MHC in the Japanese population
    Kazuhiko Nakabayashi; Atsushi Tajima; Ken Yamamoto; Atsushi Takahashi; Kenichiro Hata; Yasuo Takashima; Midori Koyanagi; Hirofumi Nakaoka; Takashi Akamizu; Naofumi Ishikawa; Sumihisa Kubota; Shiro Maeda; Tatsuhiko Tsunoda; Michiaki Kubo; Naoyuki Kamatani; Yusuke Nakamura; Takehiko Sasazuki; Senji Shirasawa
    JOURNAL OF HUMAN GENETICS, 2011年11月, 査読有り, 通常論文
  • APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population
    Chikako Kiyohara; Yoshihiro Miyake; Midori Koyanagi; Takahiro Fujimoto; Senji Shirasawa; Keiko Tanaka; Wakaba Fukushima; Satoshi Sasaki; Yoshio Tsuboi; Tatsuo Yamada; Tomoko Oeda; Takami Miki; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yoshio Hirota; Masaki Nagai
    JOURNAL OF NEURAL TRANSMISSION, 2011年09月, 査読有り, 通常論文
  • BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
    Eleni Makrodouli; Eftychia Oikonomou; Michal Koc; Ladislav Andera; Takehiko Sasazuki; Senji Shirasawa; Alexander Pintzas
    MOLECULAR CANCER, 2011年09月, 査読有り, 通常論文
  • KRAS-induced Actin-interacting Protein: A Potent Target for Obesity, Diabetes and Cancer
    Takahiro Fujimoto; Senji Shirasawa
    ANTICANCER RESEARCH, 2011年07月, 査読有り, 通常論文
  • Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population
    Chikako Kiyohara; Yoshihiro Miyake; Midori Koyanagi; Takahiro Fujimoto; Senji Shirasawa; Keiko Tanaka; Wakaba Fukushima; Satoshi Sasaki; Yoshio Tsuboi; Tatsuo Yamada; Tomoko Oeda; Hiroyuki Shimada; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yoshio Hirota; Masaki Nagai
    BMC NEUROLOGY, 2011年07月, 査読有り, 通常論文
  • Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells
    Toshiyuki Tsunoda; Yasuo Takashima; Yasuhiro Yoshida; Keiko Doi; Yoko Tanaka; Takahiro Fujimoto; Takashi Machida; Takeharu Ota; Midori Koyanagi; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
    ANTICANCER RESEARCH, 2011年07月, 査読有り, 通常論文
  • KRAS-mediated Up-regulation of RRM2 Expression Is Essential for the Proliferation of Colorectal Cancer Cell Lines
    Yasuhiro Yoshida; Toshiyuki Tsunoda; Keiko Doi; Yoko Tanaka; Takahiro Fujimoto; Takashi Machida; Takeharu Ota; Midori Koyanagi; Yasuo Takashima; Takehiko Sasazuki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
    ANTICANCER RESEARCH, 2011年07月, 査読有り, 通常論文
  • KRAS-induced actin-interacting protein regulates inositol 1,4,5-trisphosphate-receptor-mediated calcium release
    Takahiro Fujimoto; Takashi Machida; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Masahide Kuroki; Senji Shirasawa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011年05月, 査読有り, 通常論文
  • The Solute Carrier Family 15A4 Regulates TLR9 and NOD1 Functions in the Innate Immune System and Promotes Colitis in Mice
    Shigemi Sasawatari; Tadashi Okamura; Eiji Kasumi; Kaori Tanaka-Furuyama; Rieko Yanobu-Takanashi; Senji Shirasawa; Norihiro Kato; Noriko Toyama-Sorimachi
    GASTROENTEROLOGY, 2011年05月, 査読有り, 通常論文
  • Determination of the critical region of KRAS-induced actin-interacting protein for the interaction with inositol 1,4,5-trisphosphate receptor
    Takahiro Fujimoto; Takashi Machida; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Masahide Kuroki; Senji Shirasawa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011年05月, 査読有り, 通常論文
  • KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells
    Takahiro Fujimoto; Takashi Machida; Yoko Tanaka; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Tadashi Okamura; Masahide Kuroki; Senji Shirasawa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011年04月, 査読有り, 通常論文
  • ZFAT IS A CRITICAL MOLECULE FOR CELL SURVIVAL IN MOUSE EMBRYONIC FIBROBLASTS
    Keiko Doi; Takahiro Fujimoto; Midori Koyanagi; Toshiyuki Tsunoda; Yoko Tanaka; Yasuhiro Yoshida; Yasuo Takashima; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
    CELLULAR & MOLECULAR BIOLOGY LETTERS, 2011年03月, 査読有り, 通常論文
  • Oncogenic Kras Promotes Chemotherapy-Induced Growth Factor Shedding via ADAM17
    Sandra Van Schaeybroeck; Joan N. Kyula; Audrey Fenton; Catherine S. Fenning; Takehiko Sasazuki; Senji Shirasawa; Daniel B. Longley; Patrick G. Johnston
    CANCER RESEARCH, 2011年02月, 査読有り, 通常論文
  • Case-Control Study of Eczema Associated with IL13 Genetic Polymorphisms in Japanese Children
    Yoshihiro Miyake; Chikako Kiyohara; Midori Koyanagi; Takahiro Fujimoto; Senji Shirasawa; Keiko Tanaka; Satoshi Sasaki; Yoshio Hirota
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2011年, 査読有り, 通常論文
  • Pancreatic Hypertrophy in Ki-ras-Induced Actin-Interacting Protein Gene Knockout Mice
    Kyoko Miyasaka; Takahiro Fujimoto; Takako Kawanami; Soichi Takiguchi; Atsuo Jimi; Akihiro Funakoshi; Senji Shirasawa
    PANCREAS, 2011年01月, 査読有り, 通常論文
  • ZFAT is essential for endothelial cell assembly and the branch point formation of capillary-like structures in an angiogenesis model
    Yasuhiro Yoshida; Toshiyuki Tsunoda; Yasuo Takashima; Takahiro Fujimoto; Keiko Doi; Takehiko Sasazuki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
    CELLULAR & MOLECULAR BIOLOGY LETTERS, 2010年12月, 査読有り, 通常論文
  • LRRIC2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson's disease: A case-control study in Japan
    Yoshihiro Miyake; Yoshio Tsuboi; Midori Koyanagi; Takahiro Fujimoto; Senji Shirasawa; Chikako Kiyohara; Keiko Tanaka; Wakaba Fukushima; Satoshi Sasaki; Tatsuo Yamada; Tomoko Oeda; Takami Miki; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yoshio Hirota; Masaki Nagai
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2010年10月, 査読有り, 通常論文
  • GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population
    C. Kiyohara; Y. Miyake; M. Koyanagi; T. Fujimoto; S. Shirasawa; K. Tanaka; W. Fukushima; S. Sasaki; Y. Tsuboi; T. Yamada; T. Oeda; T. Miki; N. Kawamura; N. Sakae; H. Fukuyama; Y. Hirota; M. Nagai
    PARKINSONISM & RELATED DISORDERS, 2010年08月, 査読無し, 通常論文
  • Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands
    Toshiyuki Tsunoda; Yasuo Takashima; Yoko Tanaka; Takahiro Fujimoto; Keiko Doi; Yumiko Hirose; Midori Koyanagi; Yasuhiro Yoshida; Tadashi Okamura; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010年08月, 査読有り, 通常論文
  • Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus
    Federica Di Nicolantonio; Sabrina Arena; Josep Tabernero; Stefano Grosso; Francesca Molinari; Teresa Macarulla; Mariangela Russo; Carlotta Cancelliere; Davide Zecchin; Luca Mazzucchelli; Takehiko Sasazuki; Senji Shirasawa; Massimo Geuna; Milo Frattini; Jose Baselga; Margherita Gallicchio; Stefano Biffo; Alberto Bardelli
    JOURNAL OF CLINICAL INVESTIGATION, 2010年08月, 査読有り, 通常論文
  • 4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors
    Qing-Bai She; Ensar Halilovic; Qing Ye; Wei Zhen; Senji Shirasawa; Takehiko Sasazuki; David B. Solit; Neal Rosen
    CANCER CELL, 2010年07月, 査読有り, 通常論文
  • Three-dimensionally Specific Inhibition of DNA Repair-Related Genes by Activated KRAS in Colon Crypt Model
    Toshiyuki Tsunoda; Yasuo Takashima; Takahiro Fujimoto; Midori Koyanagi; Yasuhiro Yoshida; Keiko Doi; Yoko Tanaka; Tanaka; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
    NEOPLASIA, 2010年05月, 査読有り, 通常論文
  • Osteoblast-specific Factor 2 Expression in Prostate Cancer-associated Stroma: Identification Through Microarray Technology
    Bungo Furusato; Toshiyuki Tsunoda; Syed Shaheduzzaman; Martin E. Nau; Maryanne Vahey; Gyorgy Petrovics; David G. McLeod; Seiji Naito; Senji Shirasawa; Shiv Srivastava; Isabell A. Sesterhenn
    UROLOGY, 2010年04月, 査読有り, 通常論文
  • Recent advances in the association studies of autoimmune thyroid disease and the functional characterization of AITD-related transcription factor ZFAT.
    Nakabayashi K; Shirasawa S
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2010年, 査読有り, 通常論文
  • Oncogenic KRAS and BRAF Differentially Regulate Hypoxia-inducible Factor-1 alpha and-2 alpha in Colon Cancer
    Hirotoshi Kikuchi; Maria S. Pino; Min Zeng; Senji Shirasawa; Daniel C. Chung
    CANCER RESEARCH, 2009年11月, 査読有り, 通常論文
  • The Increased Expression of Periostin During Early Stages of Prostate Cancer and Advanced Stages of Cancer Stroma
    Toshiyuki Tsunoda; Bunjo Furusato; Yasuo Takashima; Suma Ravulapalli; Albert Dobi; Shiv Srivastava; David G. McLeod; Isabell A. Sesterhenn; David K. Ornstein; Senji Shirasawa
    PROSTATE, 2009年09月, 査読有り, 通常論文
  • Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-RaSG13D
    Alessandro Palmioli; Elena Sacco; Cristina Airoldi; Federica Di Nicolantonio; Annalisa D'Urzo; Senji Shirasawa; Takehiko Sasazuki; Alessandro Di Domizio; Luca De Gioia; Enzo Martegani; Alberto Bardelli; Francesco Peri; Marco Vanoni
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009年09月, 査読有り, 通常論文
  • Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers
    Kazuhiko Nakabayashi; Gen Komaki; Atsushi Tajima; Tetsuya Ando; Mayuko Ishikawa; Junko Nomoto; Kenichiro Hata; Akira Oka; Hidetoshi Inoko; Takehiko Sasazuki; Senji Shirasawa
    JOURNAL OF HUMAN GENETICS, 2009年09月, 査読有り, 通常論文
  • TGF-beta Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a beta-Catenin-independent Pathway
    Patty Trobridge; Sue Knoblaugh; M. Kay Washington; Nina M. Munoz; Karen D. Tsuchiya; Andres Rojas; Xiaoling Song; Cornelia M. Ulrich; Takehiko Sasazuki; Senji Shirasawa; William M. Grady
    GASTROENTEROLOGY, 2009年05月, 査読有り, 通常論文
  • [Genome-wide association studies: recent advances and future directions].
    Nakabayashi K; Tajima A; Shirasawa S
    Nihon rinsho. Japanese journal of clinical medicine, 2009年03月, 査読有り, 通常論文
  • ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells
    Takahiro Fujimoto; Keiko Doi; Midori Koyanagi; Toshiyuki Tsunoda; Yasuo Takashima; Yasuhiro Yoshida; Takehiko Sasazuki; Senji Shirasawa
    FEBS LETTERS, 2009年02月, 査読有り, 通常論文
  • Altered Energy Homeostasis and Resistance to Diet-Induced Obesity in KRAP-Deficient Mice
    Takahiro Fujimoto; Kyoko Miyasaka; Midori Koyanagi; Toshiyuki Tsunoda; Iwai Baba; Keiko Doi; Minoru Ohta; Norihiro Kato; Takehiko Sasazuki; Senji Shirasawa
    PLOS ONE, 2009年01月, 査読有り, 通常論文
  • Oncogenic ras-induced downregulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells.
    Yoo BH; Woo X; Li Y; Haniff M; Sasazuki T; Shirasawa S; Eskelinen EL; Rosen KV
    J. Biol. Chem., 2009年, 査読有り, 通常論文
  • Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2
    Nicole Fehrenbacher; Lone Bastholm; Thomas Kirkegaard-Sorensen; Bo Rafn; Trine Bottzauw; Christina Nielsen; Ekkehard Weber; Senji Shirasawa; Tuula Kallunki; Marja Jaattela
    CANCER RESEARCH, 2008年08月, 査読有り, 通常論文
  • Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: The role of p53 and p21
    Jose M. Escandell; Pawan Kaler; M. Carmen Recio; Takehiko Sasazuki; Senji Shirasawa; Leonard Augenlicht; Jose-Luis Rios; Lidija Klampfer
    BIOCHEMICAL PHARMACOLOGY, 2008年07月, 査読有り, 通常論文
  • Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts
    S. Shahrzad; S. Shirasawa; T. Sasazuki; J. W. Rak; B. L. Coomber
    ONCOGENE, 2008年06月, 査読有り, 通常論文
  • TATA box-binding protein-associated factor 12 is important for RAS-induced transformation properties of colorectal cancer cells
    Angeliki Voulgari; Stella Voskou; Laszlo Tora; Irwin Davidson; Takehiko Sasazuki; Senji Shirasawa; Alexander Pintzas
    MOLECULAR CANCER RESEARCH, 2008年06月, 査読有り, 通常論文
  • ZFAT expression in B and T lymphocytes and identification of ZFAT-regulated genes
    Midori Koyanagi; Kazuhiko Nakabayashi; Takahiro Fujimoto; Ning Gu; Iwai Baba; Yasuo Takashima; Keiko Doi; Haruhito Harada; Norihiro Kato; Takehiko Sasazuki; Senji Shirasawa
    GENOMICS, 2008年05月, 査読有り, 通常論文
  • Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma
    Steven Yea; Goutham Narla; Xiao Zhao; Rakhi Garg; Sigal Tal-Kremer; Eldad Hod; Augusto Villanueva; Johnny Loke; Mirko Tarocchi; Kunihara Akita; Senji Shirasawa; Takehiko Sasazuki; John A. Martignetti; Josep M. Llovet; Scott L. Friedman
    GASTROENTEROLOGY, 2008年05月, 査読有り, 通常論文
  • Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q
    F. Takeuchi; Y. Ochiai; M. Serizawa; K. Yanai; N. Kuzuya; H. Kajio; S. Honjo; N. Takeda; Y. Kaburagi; K. Yasuda; S. Shirasawa; T. Sasazuki; N. Kato
    JOURNAL OF HUMAN GENETICS, 2008年04月, 査読有り, 通常論文
  • HDAC2 deficiency sensitizes colon cancer cells to TNF alpha-induced apoptosis through inhibition of NF-kappa B activity
    Pawan Kaler; Takehiko Sasazuki; Senji Shirasawa; Leonard Augenlicht; Lidija Klampfer
    EXPERIMENTAL CELL RESEARCH, 2008年04月, 査読有り, 通常論文
  • Functional analysis of ZFAT through specific siRNA against ZFAT in Ba/F3 cell line.
    Midori Koyanagi; Keiko Doi; Takahiro Fujimoto; Toshiyuki Tsunoda; Yasuo Takashima; Senji Shirasawa
    Medical Bulletin of Fukuoka University, 2008年, 査読有り, 通常論文
  • Analysis of KRAP expression and localization, and genes regulated by KRAP in a human colon cancer cell line
    Takahiro Fujimoto; Midori Koyanagi; Iwai Baba; Kazuhiko Nakabayashi; Norihiro Kato; Takehiko Sasazuki; Senji Shirasawa
    JOURNAL OF HUMAN GENETICS, 2007年12月, 査読有り, 通常論文
  • Histone deacetylase inhibitors induce cell death selectively in cells that Harbor activated kRasV12: The role of signal transducers and activators of transcription 1 and p21
    Lidija Klampfer; Jie Huang; Senji Shirasawa; Takehiko Sasazuki; Leonard Augenlicht
    CANCER RESEARCH, 2007年09月, 査読有り, 通常論文
  • Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo
    Mathieu Derouet; Xue Wu; Linda May; Byong Hoon Yoo; Takehiko Sasazuki; Senji Shirasawa; Janusz Rak; Kirill V. Rosen
    NEOPLASIA, 2007年07月, 査読有り, 通常論文
  • Search of type 2 diabetes susceptibility gene on chromosome 20q
    F. Takeuchi; K. Yanai; H. Inomata; N. Kuzuya; H. Kajio; S. Honjo; N. Takeda; Y. Kaburagi; K. Yasuda; S. Shirasawa; T. Sasazuki; N. Kato
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007年06月, 査読有り, 通常論文
  • Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells
    Faiy H. Psahoulia; Sophy Moumtzi; Michael L. Roberts; Takehiko Sasazuki; Senji Shirasawa; Alexander Pintzas
    CARCINOGENESIS, 2007年05月, 査読有り, 通常論文
  • Transcriptional control of the human high mobility group A1 gene: Basal and oncogenic Ras-regulated expression
    Isabelle Cleynen; Christel Huysmans; Takehiko Sasazuki; Senji Shirasawa; Wim Van de Ven; Kristel Peeters
    CANCER RESEARCH, 2007年05月, 査読有り, 通常論文
  • STAT1-independent inhibition of cyclooxygenase-2 expression by IFN gamma; a common pathway of IFN gamma-mediated gene repression but not gene activation
    L. Klampfer; J. Huang; P. Kaler; T. Sasazuki; S. Shirasawa; L. Augenlicht
    ONCOGENE, 2007年03月, 査読有り, 通常論文
  • ゲノムワイド解析による摂食障害遺伝子の探索と今後の課題(パネルディスカッション : 肥満・摂食障害の分子機構,2006年,第47回日本心身医学会総会(東京))
    中林 一彦; 白澤 専二
    心身医学, 2007年
  • Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells
    Aparna V. Sarthy; Susan E. Morgan-Lappe; Dorothy Zakula; Lawrence Vernetti; Mark Schurdak; Jeremy C. L. Packer; Mark G. Anderson; Senji Shirasawa; Takehiko Sasazuki; Stephen W. Fesik
    MOLECULAR CANCER THERAPEUTICS, 2007年01月, 査読有り, 通常論文
  • Detachment-induced upregulation of XIAP and cIAP2 delays anoikis of intestinal epithelial cells
    Z. Liu; H. Li; X. Wu; B. H. Yoo; S. R. Yan; A. W. Stadnyk; T. Sasazuki; S. Shirasawa; E. C. LaCasse; R. G. Korneluk; K. V. Rosen
    ONCOGENE, 2006年12月, 査読有り, 通常論文
  • Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells
    F Teraishi; W Guo; LD Zhang; FQ Dong; JJ Davis; T Sasazuki; S Shirasawa; JS Liu; BL Fang
    CANCER RESEARCH, 2006年06月, 査読無し, 通常論文
  • Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm
    ZP Liu; HB Li; M Derouet; A Berezkin; T Sasazuki; S Shirasawa; K Rosen
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006年05月, 査読無し, 通常論文
  • KRAS(D13) promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand
    N Smakman; DJM van den Wollenberg; SG Elias; T Sasazuki; S Shirasawa; RC Hoeben; IHMB Rinkes; O Kranenblug
    CANCER RESEARCH, 2006年05月, 査読無し, 通常論文
  • Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells
    S Sugiyama; K Nakabayashi; Baba, I; T Sasazuki; S Shirasawa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005年11月, 査読無し, 通常論文
  • Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
    LP Cheng; OA Samad; Y Xu; R Mizuguchi; P Luo; S Shirasawa; M Goulding; QF Ma
    NATURE NEUROSCIENCE, 2005年11月, 査読無し, 通常論文
  • Ischemia-induced K-ras mutations in human colorectal cancer cells: Role of microenvironmental regulation of MSH2 expression
    S Shahrzad; L Quayle; C Stone; C Plumb; S Shirasawa; JW Rak; BL Coomber
    CANCER RESEARCH, 2005年09月, 査読無し, 通常論文
  • Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway
    KG Drosopoulos; ML Roberts; L Cermak; T Sasazuki; S Shirasawa; L Andera; A Pintzas
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005年06月, 査読無し, 通常論文
  • Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis
    L Klampfer; LA Swaby; H Huang; T Sasazuki; S Shirasawa; L Augenlicht
    ONCOGENE, 2005年06月, 査読無し, 通常論文
  • A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities
    Y Kochi; R Yamada; A Suzuki; JB Harley; S Shirasawa; T Sawada; SC Bae; S Tokuhiro; XT Chang; A Sekine; A Takahashi; T Tsunoda; Y Ohnishi; KM Kaufman; CSP Kang; CW Kang; S Otsubo; W Yumura; A Mimori; T Koike; Y Nakamura; T Sasazuki; K Yamamoto
    NATURE GENETICS, 2005年05月, 査読無し, 通常論文
  • Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease
    H Hiratani; DW Bowden; S Ikegami; S Shirasawa; A Shimizu; Y Iwatani; T Akamizu
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005年05月, 査読無し, 通常論文
  • Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells
    RW Caron; A Yacoub; C Mitchell; XY Zhu; Y Hong; T Sasazuki; S Shirasawa; MP Hagan; S Grant; P Dent
    CELL CYCLE, 2005年03月, 査読有り, 通常論文
  • Mapping of the critical region of mitogene-inducible gene-6 for NK-κB activation.
    Mabuchi R; Sasazuki T; Shirasawa S
    Oncol. Rep., 2005年03月, 査読無し, 通常論文
  • H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent
    RW Caron; A Yacoub; XY Zhu; C Mitchell; SI Han; T Sasazuki; S Shirasawa; MP Hagan; S Grant; P Dent
    MOLECULAR CANCER THERAPEUTICS, 2005年02月, 査読無し, 通常論文
  • Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells
    CB Pollock; S Shirasawa; T Sasazuki; W Kolch; AS Dhillon
    CANCER RESEARCH, 2005年02月, 査読無し, 通常論文
  • Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival
    RW Caron; A Yacoub; M Li; XY Zhu; C Mitchell; Y Hong; W Hawkins; T Sasazuki; S Shirasawa; AP Kozikowski; PA Dennis; MP Hagan; S Grant; P Dent
    MOLECULAR CANCER THERAPEUTICS, 2005年02月, 査読無し, 通常論文
  • Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis
    JL Yu; L May; Lhotak, V; S Shahrzad; S Shirasawa; JI Weitz; BL Coomber; N Mackman; JW Rak
    BLOOD, 2005年02月, 査読無し, 通常論文
  • Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese
    H Nawata; S Shirasawa; N Nakashima; E Araki; J Hashiguchi; S Miyake; T Yamauchi; K Hamaguchi; H Yoshimatsu; H Takeda; H Fukushima; T Sasahara; K Yamaguchi; N Sonoda; T Sonoda; M Matsumoto; Y Tanaka; H Sugimoto; H Tsubouchi; T Inoguchi; T Yanase; N Wake; K Narazaki; T Eto; F Umeda; M Nakazaki; J Ono; T Asano; Y Ito; S Akazawa; Hazegawa, I; N Takasu; M Shinohara; T Nishikawa; S Nagafuchi; T Okeda; K Eguchi; M Iwase; M Ishikawa; M Aoki; N Keicho; N Kato; K Yasuda; K Yamamoto; T Sasazuki
    JOURNAL OF HUMAN GENETICS, 2004年11月, 査読有り, 通常論文
  • Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity
    S Shichijo; N Keicho; HT Long; T Quy; NC Phi; LD Ha; VV Ban; S Itoyama; CJ Hu; N Komatsu; T Kirikae; F Kirikae; S Shirasawa; M Kaji; T Fukuda; M Sata; T Kuratsuji; K Itoh; T Sasazuki
    TISSUE ANTIGENS, 2004年11月, 査読有り, 通常論文
  • In vitro visualization of respiratory neuron activity in the newborn mouse ventral medulla
    H Onimaru; A Arata; S Arata; S Shirasawa; ML Cleary
    DEVELOPMENTAL BRAIN RESEARCH, 2004年11月, 査読有り, 通常論文
  • SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease
    S Shirasawa; H Harada; K Furugaki; T Akamizu; N Ishikawa; K Ito; K Ito; H Tamai; K Kuma; S Kubota; H Hiratani; T Tsuchiya; Baba, I; M Ishikawa; M Tanaka; K Sakai; M Aoki; K Yamamoto; T Sasazuki
    HUMAN MOLECULAR GENETICS, 2004年10月, 査読有り, 通常論文
  • Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage
    S Shirasawa; S Sugiyama; Baba, I; J Inokuchi; S Sekine; K Ogino; Y Kawamura; T Dohi; M Fujimoto; T Sasazuki
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004年09月, 査読有り, 通常論文
  • B lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse
    N Asano; M Fujimoto; N Yazawa; S Shirasawa; M Hasegawa; H Okochi; K Tamaki; TF Tedder; S Sato
    AMERICAN JOURNAL OF PATHOLOGY, 2004年08月, 査読無し, 通常論文
  • Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression
    L Klampfer; J Huang; T Sasazuki; S Shirasawa; L Augenlicht
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004年08月, 査読有り, 通常論文
  • Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
    LP Cheng; A Arata; R Mizuguchi; Y Qian; A Karunaratne; PA Gray; S Arata; S Shirasawa; M Bouchard; P Luo; CL Chen; M Busslinger; M Goulding; H Onimaru; QF Ma
    NATURE NEUROSCIENCE, 2004年05月, 査読有り, 通常論文
  • P38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor
    XM Qi; J Tang; R Pramanik; RM Schultz; S Shirasawa; T Sasazuki; JH Han; G Chen
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004年05月, 査読有り, 通常論文
  • Association of the T-cell regulatory gene CTLA4 with Graves’ disease and autoimmune thyroid disease in the Japanese
    Furugaki K; Shirasawa S; Isikawa N; Ito K; Ito K; Kubota S; Kuma K; Tamai H; Akamizu T; Hiratani H; Tanaka M; Sasazuki T
    J. Hum. Gent., 2004年03月, 査読有り, 通常論文
  • Polycomb group suppressor of zeste 12 links heterochromatin protein 1 alpha and enhancer of zeste 2
    K Yamamoto; M Sonoda; J Inokuchi; S Shirasawa; T Sasazuki
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004年01月, 査読有り, 通常論文
  • Deregulated expression of KRAP, a novel gene encoding actin-interacting protein, in human colon cancer cells
    J Inokuchi; M Komiya; Baba, I; S Naito; T Sasazuki; S Shirasawa
    JOURNAL OF HUMAN GENETICS, 2004年01月, 査読無し, 通常論文
  • Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/- mice
    MA Parisi; AE Baldessari; MHK Iida; CM Clarke; B Doggett; S Shirasawa; RP Kapur
    GASTROENTEROLOGY, 2003年11月, 査読無し, 通常論文
  • Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression
    L Klampfer; J Huang; G Corner; J Mariadason; D Arango; T Sasazuki; S Shirasawa; L Augenlicht
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003年11月, 査読有り, 通常論文
  • Inhibition of interferon gamma signaling by the short chain fatty acid butyrate
    L Klampfer; J Huang; T Sasazuki; S Shirasawa; L Augenlicht
    MOLECULAR CANCER RESEARCH, 2003年09月, 査読有り, 通常論文
  • Met receptor overexpression and oncogenic Ki-ras mutation cooperate to enhance tumorigenicity of colon cancer cells in vivo
    IS Long; K Han; M Li; S Shirasawa; T Sasazuki; M Johnston; MS Tsao
    MOLECULAR CANCER RESEARCH, 2003年03月, 査読無し, 通常論文
  • A novel mechanism of nuclear factor ・B activation through the binding between inhibitor of nuclear factor-・Bτ and the processed NH2-terminal region of Mig-6
    Tsunoda T; Inokuchi J; Baba I; Okumura K; Naito S; Sasazuki T; Shirasawa S
    Cancer Research, 2002年10月, 査読無し, 通常論文
  • Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1
    Y Qian; S Shirasawa; CL Chen; LP Cheng; QF Ma
    GENES & DEVELOPMENT, 2002年05月, 査読無し, 通常論文
  • Congenital central hypoventilation syndrome: a novel mutation of the RET gene in an isolated case
    M Kanai; C Numakura; A Sasaki; E Shirahata; K Akaba; M Hashimoto; H Hasegawa; S Shirasawa; K Hayasaka
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2002年04月, 査読無し, 通常論文
  • The impact of oncogenes on tumor maintenance
    Shirasawa S; Sasazuki T
    Oncogene-Directed Therapies (Rak JW. Ed., Human Press Inc., Totowa), 2002年, 査読無し, 通常論文
  • Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3
    Y Qian; B Fritzsch; S Shirasawa; CL Chen; YJ Choi; QF Ma
    GENES & DEVELOPMENT, 2001年10月, 査読無し, 通常論文
  • Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q133 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese
    K Sakai; S Shirasawa; N Ishikawa; K Ito; H Tamai; K Kuma; T Akamizu; M Tanimura; K Furugaki; K Yamamoto; T Sasazuki
    HUMAN MOLECULAR GENETICS, 2001年06月, 査読無し, 通常論文
  • cDNA array analyses of K-Ras-induced gene transcription
    GG Habets; M Knepper; J Sumortin; YJ Choi; T Sasazuki; S Shirasawa; G Bollag
    REGULATORS AND EFFECTORS OF SMALL GTPASES, PT F, RAS FAMILY I, 2001年, 査読無し, 通常論文
  • Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells
    Baba, I; S Shirasawa; R Iwamoto; K Okumura; T Tsunoda; M Nishioka; K Fukuyama; K Yamamoto; E Mekada; T Sasazuki
    CANCER RESEARCH, 2000年12月, 査読無し, 通常論文
  • Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19(ARF)
    S Ries; C Biederer; D Woods; O Shifman; S Shirasawa; T Sasazuki; M McMahon; M Oren; F McCormick
    CELL, 2000年10月, 査読無し, 通常論文
  • Rnx deficiency results in congenital central hypoventilation
    S Shirasawa; A Arata; H Onimaru; KA Roth; GA Brown; S Horning; S Arata; K Okumura; T Sasazuki; SJ Korsmeyer
    NATURE GENETICS, 2000年03月, 査読無し, 通常論文
  • Targeted disruption of the K-Ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis
    H Allgayer; H Wang; S Shirasawa; T Sasazuki; D Boyd
    BRITISH JOURNAL OF CANCER, 1999年08月, 査読無し, 通常論文
  • Activated Ki-ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells
    K Okumura; S Shirasawa; M Nishioka; T Sasazuki
    CANCER RESEARCH, 1999年05月, 査読無し, 通常論文
  • Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
    F Okada; JW Rak; B St Croix; B Lieubeau; M Kaya; L Roncari; S Shirasawa; T Sasazuki; RS Kerbel
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998年03月, 査読無し, 通常論文
  • MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line
    CJ Savoie; N Kamikawaji; T Sudo; M Furuse; S Shirasawa; T Tana; T Sasazuki
    CANCER LETTERS, 1998年01月, 査読無し, 通常論文
  • Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells
    M Ohmori; S Shirasawa; M Furuse; K Okumura; T Sasazuki
    CANCER RESEARCH, 1997年11月, 査読無し, 通常論文
  • Suppression of serum-induced c-jun expression by activated Ki-ras in human colon cancer cells
    M Furuse; S Shirasawa; K Okumura; M Ohmori; T Sasazuki
    JAPANESE JOURNAL OF HUMAN GENETICS, 1997年09月, 査読無し, 通常論文
  • Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon
    S Shirasawa; AMR Yunker; KA Roth; GA Brown; S Horning; SJ Korsmeyer
    NATURE MEDICINE, 1997年06月, 査読無し, 通常論文
  • MUTANT RAS ONCOGENES UP-REGULATE VEGF/VPF EXPRESSION - IMPLICATIONS FOR INDUCTION AND INHIBITION OF TUMOR ANGIOGENESIS
    J RAK; Y MITSUHASHI; L BAYKO; J FILMUS; S SHIRASAWA; T SASAZUKI; RS KERBEL
    CANCER RESEARCH, 1995年10月, 査読無し, 通常論文
  • ALTERED GROWTH OF HUMAN COLON CANCER CELL-LINES DISRUPTED AT ACTIVATED KI-RAS
    S SHIRASAWA; M FURUSE; N YOKOYAMA; T SASAZUKI
    SCIENCE, 1993年04月, 査読無し, 通常論文
  • P53 GENE-MUTATIONS IN COLORECTAL TUMORS FROM PATIENTS WITH FAMILIAL POLYPOSIS-COLI
    S SHIRASAWA; K URABE; Y YANAGAWA; K TOSHITANI; T IWAMA; T SASAZUKI
    CANCER RESEARCH, 1991年06月, 査読無し, 通常論文
■ MISC
  • Znフィンガータンパク質Zfatのセントロメアへの局在
    石倉 周平; 中林 一彦; 白澤 専二
    日本生化学会大会プログラム・講演要旨集, 2018年09月, 査読無し, 通常論文
  • 新規レスベラトロール誘導体は大腸癌細胞三次元増殖を抑制する
    澤田 悠賀; 松川 泰治; 土井 聡; 角田 俊之; 岡本 春奈; 苗村 円佳; 田原 圭一郎; 有川 和沙; 松岡 耕平; 原田 正樹; 大貫 宏一郎; 白澤 専二; 神武 洋二郎
    生命科学系学会合同年次大会, 2017年12月, 査読無し, 通常論文
  • 消化器癌に対する遺伝子療法の抗腫瘍抗体による標的化
    白澤専二; 鍋島一樹; 黒木政秀; 立花克郎; 山下裕一; 向坂彰太郎; 岩本隆宏; 朔啓二郎; 廣松賢治; 斉藤喬雄; 宮本新吾; 田村和夫; 原 周司
    私立大学戦略的基盤形成支援事業報告書 福岡大学基盤研究機関先端分子医学研究所 平成20-24年度, 2013年, 査読無し, 通常論文
  • 癌・生活習慣病・免疫関連疾患の病因・病態解明と分子標的療法開発/消化器癌に対する遺伝子療法の抗腫瘍抗体による標的化
    白澤専二; 鍋島一樹; 黒木政秀; 立花克郎; 山下裕一; 向坂彰太郎; 岩本隆宏; 朔啓二郎; 廣松賢治; 斉藤喬雄; 宮本新吾; 田村和夫; 原 周司
    先端分子医学研究センター 2009年度年報, 2011年, 査読無し, 通常論文
  • Translational regulation of hypoxia-inducible factor-1 alpha and 2 alpha by mutant oncogenes in colon cancer
    Hirotoshi Kikuchi; Maria S. Pino; Min Zeng; Senji Shirasawa; Hiroyuki Konno; Daniel C. Chung
    CANCER RESEARCH, 2010年04月, 査読無し, 通常論文
■ 所属学協会
  • バイオ治療法研究会
  • 日本癌学会
■ 共同研究・競争的資金等の研究課題
  • 新規抗腫瘍薬を利用した腫瘍免疫微小環境におけるKRAS制御機構の解明と制御法開発
    基盤研究(C)
    福岡大学
    2021年04月01日 - 2024年03月31日
  • 大腸癌細胞塊における生体内類似変異KRAS制御シグナルの解明及び阻害剤の開発
    基盤研究(C)
    福岡大学
    2018年04月01日 - 2021年03月31日
  • 変異KRASが制御する微小環境と発癌分子機構の解明
    基盤研究(C)
    福岡大学
    2015年04月01日 - 2018年03月31日
  • 肺癌における変異KRAS制御末梢分泌型microRNAの解析
    若手研究(B)
    福岡大学
    2012年04月01日 - 2015年03月31日
  • 免疫疾患関連転写因子ZFATのコンディショナルノックアウトマウスを用いた機能解析
    基盤研究(C)
    福岡大学
    2012年04月01日 - 2015年03月31日
  • 変異KRASを起点とした大腸癌フィールドエフェクトの解明
    基盤研究(C)
    福岡大学
    2012年04月01日 - 2015年03月31日
  • 自己免疫疾患関連転写制御因子の生命機能における基盤的研究
    基盤研究(B)
    福岡大学
    2009年 - 2012年
  • 糖尿病の遺伝素因に基づいた創薬に関する試験研究
    2006年07月 - 2010年03月
  • ゲノムネットワークプロジェクト
    2006年06月 - 2009年05月
  • ゲノムネットワークプロジェクト
    2006年06月 - 2009年05月
  • ゲノムネットワークプロジェクト
    2006年06月 - 2009年05月
  • 自己免疫性甲状腺疾患を中心とした自己免疫疾患関連遺伝子の解明
    特定領域研究
    国立国際医療センター(研究所)
    2005年 - 2009年
  • オーダーメイド医療実現化プロジェクト
    2006年04月 - 2008年03月
  • 自己免疫疾患関連遺伝子ZFAT及びZFATに制御される免疫疾患関連遺伝子群の解明
    基盤研究(B)
    2005年 - 2008年
  • タンパク3000プロジェクト
    2006年04月 - 2007年03月
  • 自己免疫性甲状腺疾患の疾患感受性遺伝子の同定
    特定領域研究
    2002年 - 2004年
  • 自己免疫性甲状腺疾患(橋本病)の疾患感受性遺伝子の同定とその機能解析
    基盤研究(A)
    2000年 - 2003年
  • 変異Ki-Rasにより発現制御される癌関連遺伝子の同定・機能解析
    特定領域研究(C)
    国立国際医療センター(研究所)
    2001年 - 2001年
  • 胸腺におけるT細胞レパトワ決定機構の解明
    基盤研究(B)
    九州大学
    1999年 - 2001年
  • 変異Ki-Rasにより発現制御される新規がん関連遺伝子の単離機能解析
    特定領域研究(C)
    九州大学
    2000年 - 2000年
  • 橋本病における疾患感受性遺伝子の同定
    特定領域研究(C)
    九州大学
    2000年 - 2000年
  • CD4^+CD8^+胸腺細胞特異的単クローン抗体のリガンドの同定とその機能解析
    基盤研究(C)
    九州大学
    1999年 - 2000年
  • 遺伝子標的法を用いた新規がん関連遺伝子の同定および機能解析
    特定領域研究(A)
    九州大学
    1999年 - 1999年
  • 自己免疫性甲状腺疾患の遺伝因子の解明
    基盤研究(B)
    京都大学
    1998年 - 1999年
  • アメリカ大陸を中心としたがん研究先進グループとの研究交流
    特定領域研究(A)
    東京大学
    1997年 - 1999年
  • 胸腺内T細胞分化におけるTCR・MHC/ペプチド複合体相互作用の生化学的解析
    重点領域研究
    九州大学
    1997年 - 1997年
  • HLA結合ペプチドライブラリーを用いた癌特異的T細胞の誘導及び癌抗原群の解明
    重点領域研究
    九州大学
    1997年 - 1997年
  • ヒト免疫モデルマウス(マウスMHC,CD4欠損ヒトCD4,HLA導入)の樹立-ヒト免疫応答の再現-
    基盤研究(C)
    九州大学
    1996年 - 1997年
  • HLAを利用したアレルギー反応の特異的抑制療法開発のための基礎研究
    基盤研究(A)
    九州大学
    1995年 - 1997年
  • HLA結合性ペプチドライブラリーを用いた癌特異的T細胞の誘導及び癌抗原群の同定
    重点領域研究
    九州大学
    1996年 - 1996年
  • HLA多重遺伝子族による免疫応答および疾患感受性制御の分子機構の解明
    国際学術研究
    九州大学
    1993年 - 1995年
■ 産業財産権
  • 8,580,562, PCT/JP2008/66155, ZFAT遺伝子発現制御RNA, 白澤専二, 藤本崇宏, 角田俊之, 土井佳子, 小柳 緑
  • 特許第5294344号, 特願2010-527642, 白血病治療用医薬組成物, 白澤専二, 藤本崇宏, 角田俊之, 土井佳子, 小柳緑
  • PCT/JP2010/066864, イノシトール-1,4,5-トリスリン酸受容体結合タンパク質およびそれを含むトランスジェニック非ヒト哺乳動物, 藤本崇宏, 白澤専二
  • 特許第4296016号, 特願2003-084650, エピレグリン遺伝子欠損動物およびその利用方法, 白澤専二, 笹月健彦
  • 国際公開WO2007/010999, KRAP遺伝子変異による脂質代謝および糖代謝改変動物、改変方法および改変剤, 白澤専二, 藤本崇宏