RAD52-mediated repair of DNA double-stranded breaks at inactive centromeres leads to subsequent apoptotic cell death.
Gen Maruta; Hisanori Maeoka; Toshiyuki Tsunoda; Kozaburo Akiyoshi; Satoshi Takagi; Senji Shirasawa; Shuhei Ishikura
Nucleic acids research, 27 Nov. 2024, 52(21):12961 - 12975

Inhibitory Effect of Pyra-Metho-Carnil on the Differentiation and Maturation of Macrophages in Normal and Cancer Microenvironments.
Takanori Kitaguchi; Taichi Matsumoto; Kazumasa Yoshida; Yuriko Hamaguchi; Gen Maruta; Hisanori Maeoka; Shuhei Ishikura; Michitaka Nakano; Yusuke Ishida; Fumihito Hirai; Mikiko Aoki; Shohta Kodama; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2024, 44(8):3557 - 3565

Inhibitory Effect of Pyra–Metho–Carnil on Cancer Spheroid Growth Through Decrease in Glycolysis-associated Molecules
KAZUMASA YOSHIDA; KENSUKE NISHI; SHUHEI ISHIKURA; TAICHI MATSUMOTO; KAZUHIKO NAKABAYASHI; RYO YAZAKI; TAKASHI OHSHIMA; MASAHIKO SUENAGA; SENJI SHIRASAWA; TOSHIYUKI TSUNODA
Anticancer Research, 26 Jul. 2023, 43(8):3717 - 3726

Death domain-associated protein DAXX regulates non-coding RNA transcription at the centromere through the transcription regulator ZFAT.
Shuhei Ishikura; Kazumasa Yoshida; Toshiyuki Tsunoda; Senji Shirasawa
The Journal of biological chemistry, 23 Sep. 2022, 298(11):102528 - 102528

Cryptotanshinone suppresses tumorigenesis by inhibiting lipogenesis and promoting reactive oxygen species production in KRAS‑activated pancreatic cancer cells.
Tokio Terado; Chul Jang Kim; Akiyo Ushio; Kahori Minami; Yukihiro Tambe; Susumu Kageyama; Akihiro Kawauchi; Toshiyuki Tsunoda; Senji Shirasawa; Hiroyuki Tanaka; Hirokazu Inoue
International journal of oncology, Sep. 2022, 61(3)

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis.
Kensuke Nishi; Shohei Yoshimoto; Soichiro Nishi; Tatsuro Nishi; Ryushiro Nishi; Takayuki Tanaka; Toshiyuki Tsunoda; Kazuaki Imai; Hiroaki Tanaka; Osamu Hotta; Ayaki Tanaka; Kenji Hiromatsu; Senji Shirasawa; Takashi Nakagawa; Takafumi Yamano
International journal of molecular sciences, 16 Aug. 2022, 23(16)

Standardized Methods Using EUS-guided Fine-needle Biopsy and a Minimal Medium Creates Three Pancreatic Cancer Organoids.
Yusuke Ishida; Toshiyuki Tsunoda; Yoshihiro Hamada; Naoaki Tsuchiya; Takehiko Koga; Takanori Kitaguchi; Keisuke Matsumoto; Shinji Matsumoto; Takahide Sasaki; Ryo Nakashima; Fuminori Ishii; Masatoshi Kajiwara; Senji Shirasawa; Suguru Hasegawa; Fumihito Hirai
Anticancer research, Aug. 2022, 42(8):4103 - 4109

Cancer Spheroid Proliferation Is Suppressed by a Novel Low-toxicity Compound, Pyra-Metho-Carnil, in a Context-independent Manner.
Kazumasa Yoshida; Kensuke Nishi; Shuhei Ishikura; Kazuhiko Nakabayashi; Ryo Yazaki; Takashi Ohshima; Masahiko Suenaga; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Aug. 2022, 42(8):3993 - 4001

Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.
Kensuke Nishi; Shohei Yoshimoto; Soichiro Nishi; Tatsuro Nishi; Ryushiro Nishi; Toshiyuki Tsunoda; Hiromitsu Morita; Hiroaki Tanaka; Osamu Hotta; Susumu Yasumasu; Kenji Hiromatsu; Senji Shirasawa; Takashi Nakagawa; Takafumi Yamano
In vivo (Athens, Greece), 2022, 36(5):2357 - 2364

Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment.
Imai K; Yamano T; Nishi S; Nishi R; Nishi T; Tanaka H; Tsunoda T; Yoshimoto S; Tanaka A; Hiromatsu K; Shirasawa S; Nakagawa T; Nishi K
Viruses, 2022, 14(5):907 - 907, Refereed

Fibroblast-Induced Paradoxical PI3K Pathway Activation in PTEN-Competent Colorectal Cancer: Implications for Therapeutic PI3K/mTOR Inhibition.
Conciatori F; Salvati E; Ciuffreda L; Shirasawa S; Falcone I; Cognetti F; Ferretti G; Zeuli M; Del Bufalo D; Bazzichetto C; Milella M
Front. Oncol., 2022, 12:862806, Refereed

The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes.
Ishikura S; Nagai M; Tsunoda T; Nishi K; Tanaka Y; Koyanagi M; Shirasawa S
J. Cell Biochem., 2021, 122(6):626 - 638, Refereed

Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.
Hanada K; Kawada K; Nishikawa G; Toda K; Maekawa H; Nishikawa Y; Masui H; Hirata W; Okamoto M; Kiyasu Y; Honma S; Ogawa R; Mizuno R; Itatani Y; Miyoshi H; Sasazuki T; Shirasawa S; Taketo MM; Obama K; Sakai Y
Cancer Lett., 2021, 522:129 - 141, Refereed

Effects of Aspergillus fumigatus Conidia on Apoptosis and Proliferation in an In Vitro Model of the Lung Microenvironment.
Kushima H; Tsunoda T; Matsumoto T; Kinoshita Y; Izumikawa K; Shirasawa S; Fujita M; Ishii H
Microorganisms, 2021, 9(7):1435, Refereed

Growth Suppression of Cancer Spheroids With Mutated KRAS by Low-toxicity Compounds from Natural Products.
Hashimoto S; Nagai M; Nishi K; Ishikura S; Nakabayashi K; Yazaki R; Ohshima T; Suenaga M; Shirasawa S; Tsunoda T
Anticancer Res., 2021, 41(8):4061 - 4070, Refereed

Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1.
Kandasamy P; Zlobec I; Nydegger DT; Giménez JP; Bhardwaj R; Shirasawa S; Tsunoda T; Hediger MA
Mol. Oncol., 2021, 15(10):2782 - 2800, Refereed

CENP-B promotes the centromeric localization of ZFAT to control transcription of non-coding RNA.
Ishikura S; Yoshida K; Hashimoto S; Nakabayashi K; Tsunoda T; Shirasawa S
J. Biol. Chem., 2021, :101213 - 101213, Refereed

Mutant KRAS Promotes NKG2D+ T Cell Infiltration and CD155 Dependent Immune Evasion.
Nishi K; Ishikura S; Umebayashi M; Morisaki T; Inozume T; Kinugasa T; Aoki M; Nimura S; Swain A; Yoshida Y; Hasegawa S; Nabeshima K; Sakata T; Shirasawa S; Tsunoda T
Anticancer Res., 2020, 40(8):4663 - 4674, Refereed

MK615 Suppresses Hypoxia Tolerance by Up-regulation of E-cadherin in Colorectal Cancer Cells With Mutant KRAS.
Nishi K; Tsunoda T; Uchida Y; Sueta T; Sawatsubashi M; Yamano T; Hashiguchi Y; Swain A; Shirasawa S; Sakata T
Anticancer Res., 2020, 40(8):4687 - 4694, Refereed

In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
Wong CC; Xu J; Bian X; Wu JL; Kang W; Qian Y; Li W; Chen H; Gou H; Liu D; Yat Luk ST; Zhou Q; Ji F; Chan LS; Shirasawa S; Sung JJ; Yu J
Gastroenterology, 2020, 159(6):2163 - 2180, Refereed

Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90.
Ernst A; Hennel R; Krombach J; Kapfhammer H; Brix N; Zuchtriegel G; Uhl B; Reichel CA; Frey B; Gaipl US; Winssinger N; Shirasawa S; Sasazuki T; Sperandio M; Belka C; Lauber K
Front. Oncol., 2020, 10:1668, Refereed

ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B-H4K8ac-BRD4 axis.
Ishikura S; Nakabayashi K; Nagai M; Tsunoda T; Shirasawa S
Nucleic Acids Res., 2020, 48(19):10848 - 10866, Refereed

BRAF status modulates Interelukin-8 expression through a CHOP-dependent mechanism in colorectal cancer.
Conciatori F; Bazzichetto C; Amoreo CA; Sperduti I; Donzelli S; Diodoro MG; Buglioni S; Falcone I; Shirasawa S; Blandino G; Ferretti G; Cognetti F; Milella M; Ciuffreda L
Commun. Biol., 2020, 3(1):546, Refereed

Next Generation Lipophilic Bisphosphonate Shows Antitumor Effect in Colorectal Cancer In Vitro and In Vivo.
Baranyi M; Rittler D; Molnár E; Shirasawa S; Jalsovszky I; Varga IK; Hegedűs L; Németh A; Dank M; Aigner C; Tóvári J; Tímár J; Hegedűs B; Garay T
Pathol. Oncol. Res., 2020, 26(3):1957 - 1969, Refereed

Targeting the KRAS oncogene: Synthesis, physicochemical and biological evaluation of novel G-quadruplex DNA binders.
D'Aria F; D'Amore VM; Leva FSD; Amato J; Caterino M; Russomanno P; Salerno S; Barresi E; De Leo M; Marini AM; Taliani S; Da Settimo F; Salgado GF; Pompili L; Zizza P; Shirasawa S; Novellino E; Biroccio A; Marinelli L; Giancola C
Eur. J. Pharm. Sci., 2020, 149:105337, Refereed

A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells.
Yuuga Sawata; Taiji Matsukawa; Satoshi Doi; Toshiyuki Tsunoda; Nagisa Arikawa; Natsumi Matsunaga; Koichiro Ohnuki; Senji Shirasawa; Yojiro Kotake
Molecular and cellular biochemistry, Dec. 2019, 462(1-2):25 - 31

A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells.
Sawata Y; Matsukawa T; Doi S; Tsunoda T; Arikawa N; Matsunaga N; Ohnuki K; Shirasawa S; Kotake Y
Dec. 2019, 462(1-2):25 - 31, Refereed

Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation.
Charitou T; Srihari S; Lynn MA; Jarboui MA; Fasterius E; Moldovan M; Shirasawa S; Tsunoda T; Ueffing M; Xie J; Xin J; Wang X; Proud CG; Boldt K; Al-Khalili Szigyarto C; Kolch W; Lynn DJ
Br. J. Cancer, 2019, 121(1):37 - 50, Refereed

Zfat is indispensable for the development of erythroid cells in the fetal liver.
Doi K; Tsunoda T; Koyanagi M; Tanaka Y; Yamano S; Fujikane A; Nishi K; Ishikura S; Shirasawa S
Anticancer Res., 2019, 39(8):4495 - 4502, Refereed

Acquisition of resistance to vemurafenib leads to interleukin-10 production through an aberrant activation of Akt in a melanoma cell line.
Takashi Inozume; Toshiyuki Tsunoda; Takashi Morisaki; Kazutoshi Harada; Seiji Shirasawa; Tatsuyoshi Kawamura
The Journal of dermatology, Dec. 2018, 45(12):1434 - 1439, Refereed

Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells
Byong Hoon Yoo; Iman Aftab Khan; Ananda Koomson; Pramod Gowda; Takehiko Sasazuki; Senji Shirasawa; Shashi Gujar; Kirill V. Rosen
Autophagy, 02 Jan. 2018, 14(1):134 - 151, Refereed

The long noncoding RNA OIP5-AS1 is involved in the regulation of cell proliferation
Madoka Naemura; Masahide Kuroki; Toshiyuki Tsunoda; Nagisa Arikawa; Yuuga Sawata; Senji Shirasawa; Yojiro Kotake
Anticancer Research, 01 Jan. 2018, 38(1):77 - 81, Refereed

A novel resveratrol derivative selectively inhibits the proliferation of colorectal cancer cells with KRAS mutation.
Okamoto H; Matsukawa T; Doi S; Tsunoda T; Sawata Y; Naemura M; Ohnuki K; Shirasawa S; Kotake Y
Mol. Cell Biochem., 2018, 442(1-2):39 - 45, Refereed

Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models.
Del Curatolo A; Conciatori F; Cesta Incani U; Bazzichetto C; Falcone I; Corbo V; D'Agosto S; Eramo A; Sette G; Sperduti I; De Luca T; Marabese M; Shirasawa S; De Maria R; Scarpa A; Broggini M; Del Bufalo D; Cognetti F; Milella M; Ciuffreda L
J. Exp. Clin. Cancer Res., 2018, 37(1):140, Refereed

Growth Suppression of Human Colorectal Cancer Cells with Mutated KRAS by 3-Deaza-cytarabine in 3D Floating Culture.
Luo H; Nishi K; Ishikura S; Swain A; Morishige N; Yazaki R; Ohshima T; Shirasawa S; Tsunoda T
Anticancer Res., 2018, 38(7):4247 - 4256, Refereed

In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer.
Wei R; Wong JPC; Lyu P; Xi X; Tong O; Zhang SD; Yuen HF; Shirasawa S; Kwok HF
J. Cell Mol. Med., 2018, 22(9):4097 - 4105, Refereed

Zfat expression in ZsGreen reporter gene knock-in mice: Implications for a novel function of Zfat in definitive erythropoiesis.
Tsunoda T; Doi K; Ishikura S; Luo H; Nishi K; Matsuzaki H; Koyanagi M; Tanaka Y; Okamura T; Shirasawa S
Int. J. Mol. Med., 2018, 42(5):2595 - 2603, Refereed

MACC1 regulates Fas mediated apoptosis through STAT1/3-Mcl-1 signaling in solid cancers
Harikrishnan Radhakrishnan; Katharina Ilm; Wolfgang Walther; Senji Shirasawa; Takehiko Sasazuki; Peter T. Daniel; Bernhard Gillissen; Ulrike Stein
CANCER LETTERS, Sep. 2017, 403:231 - 245, Refereed

Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS
Kensuke Nishi; Hao Luo; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Lauren Wills; George S. Baillie; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
ANTICANCER RESEARCH, Jul. 2017, 37(7):3833 - 3839, Refereed

An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.
Kensuke Nishi; Hao Luo; Kazuhiko Nakabayashi; Keiko Doi; Shuhei Ishikura; Yuri Iwaihara; Yasuhiro Yoshida; Kumpei Tanisawa; Tomio Arai; Seijiro Mori; Motoji Sawabe; Masaaki Muramatsu; Masashi Tanaka; Toshifumi Sakata; Senji Shirasawa; Toshiyuki Tsunoda
Anticancer research, Jul. 2017, 37(7):3855 - 3862, Refereed

MEK162 Enhances Antitumor Activity of 5-Fluorouracil and Trifluridine in KRAS-mutated Human Colorectal Cancer Cell Lines
Jun Gong; Yuan Chen; Lixin Yang; Raju Pillai; Senji Shirasawa; Marwan Fakih
ANTICANCER RESEARCH, Jun. 2017, 37(6):2831 - 2838, Refereed

Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae
Murugan Kalimutho; Amanda L. Bain; Bipasha Mukherjee; Purba Nag; Devathri M. Nanayakkara; Sarah K. Harten; Janelle L. Harris; Goutham N. Subramanian; Debottam Sinha; Senji Shirasawa; Sriganesh Srihari; Sandeep Burma; Kum Kum Khanna
MOLECULAR ONCOLOGY, May 2017, 11(5):470 - 490, Refereed

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1
Hirotada Tajiri; Takehito Uruno; Takahiro Shirai; Daisuke Takaya; Shigeki Matsunaga; Daiki Setoyama; Mayuki Watanabe; Mutsuko Kukimoto-Niino; Kounosuke Oisaki; Miho Ushijima; Fumiyuki Sanematsu; Teruki Honma; Takaho Terada; Eiji Oki; Senji Shirasawa; Yoshihiko Maehara; Dongchon Kang; Jean-Francois Cote; Shigeyuki Yokoyama; Motomu Kanai; Yoshinori Fukui
CELL REPORTS, May 2017, 19(5):969 - 980, Refereed

ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line.
Nishi K. Iwaihara; Y. Tsunoda; T. Doi; K; Sakata; T. Shirasawa; S. Ishikura S
Cell Death Dis., 2017, 8(12):3218 - 3218, Refereed

Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells
Shuhei Ishikura; Toshiyuki Tsunoda; Kazuhiko Nakabayashi; Keiko Doi; Midori Koyanagi; Keiko Hayashi; Tomoko Kawai; Yoko Tanaka; Yuri Iwaihara; Hao Luo; Kensuke Nishi; Tadashi Okamura; Senji Shirasawa
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, Nov. 2016, 1859(11):1398 - 1410, Refereed

Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase
Kosuke Toda; Kenji Kawada; Masayoshi Iwamoto; Susumu Inamoto; Takehiko Sasazuki; Senji Shirasawa; Suguru Hasegawa; Yoshiharu Sakai
NEOPLASIA, Nov. 2016, 18(11):654 - 665, Refereed

Oncogenic Ras influences the expression of multiple lncRNAs
Yojiro Kotake; Madoka Naemura; Kyoko Kitagawa; Hiroyuki Niida; Toshiyuki Tsunoda; Senji Shirasawa; Masatoshi Kitagawa
CYTOTECHNOLOGY, Aug. 2016, 68(4):1591 - 1596, Refereed

The Nuclear Zinc Finger Protein Zfat Maintains Fox01 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway
Shuhei Ishikura; Yuri Iwaihara; Yoko Tanaka; Hao Luo; Kensuke Nishi; Keiko Doi; Midori Koyanagi; Tadashi Okamura; Toshiyuki Tsunoda; Senji Shirasawa
JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2016, 291(29):15282 - 15291, Refereed

Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells
Hao Luo; Masayo Umebayashi; Keiko Doi; Takashi Morisaki; Senji Shirasawa; Toshiyuki Tsunoda
ANTICANCER RESEARCH, Jul. 2016, 36(7):3585 - 3589, Refereed

DBA Lectin Binds to Highly Proliferative Mouse Erythroleukemia Cells
Anthony Swain; Kasem Kulkeaw; Yuka Tanaka; Yoichi Nakanishi; Senji Shirasawa; Daisuke Sugiyama
ANTICANCER RESEARCH, Jul. 2016, 36(7):3625 - 3633, Refereed

In Hyperthermia Increased ERK and WNT Signaling Suppress Colorectal Cancer Cell Growth
Michael Bordonaro; Senji Shirasawa; Darina L. Lazarova
CANCERS, May 2016, 8(5):pii:E49, Refereed

Synthesis of New Congeners of 1-methyl-3-aminoisoquinolines, Evaluation of Their Cytotoxic Activity, In Silico and In Vitro Study of Their Molecular Targets as PDE4B
Gennady B. Lapa; Toshiyuki Tsunoda; Senji Shirasawa; Maria A. Baryshnikova; Gregory G. Evseev; Daria A. Afanasyeva; Elena A. Chigorina
CHEMICAL BIOLOGY & DRUG DESIGN, Apr. 2016, 87(4):575 - 582, Refereed

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells
Maria Goulielmaki; Evangelos Koustas; Eirini Moysidou; Margarita Vlassi; Takehiko Sasazuki; Senji Shirasawa; George Zografos; Eftychia Oikonomou; Alexander Pintzas
ONCOTARGET, Feb. 2016, 7(8):9188 - 9221, Refereed

EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer
Philip D. Dunne; Sonali Dasgupta; Jaine K. Blayney; Darragh G. McArt; Keara L. Redmond; Jessica-Anne Weir; Conor A. Bradley; Takehiko Sasazuki; Senji Shirasawa; Tingting Wang; Supriya Srivastava; Chee Wee Ong; Ken Arthur; Manuel Salto-Tellez; Richard H. Wilson; Patrick G. Johnston; Sandra Van Schaeybroeck
CLINICAL CANCER RESEARCH, Jan. 2016, 22(1):230 - 242, Refereed

ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture
Madoka Naemura; Toshiyuki Tsunoda; Yasutoshi Inoue; Haruna Okamoto; Senji Shirasawa; Yojiro Kotake
MOLECULAR AND CELLULAR BIOCHEMISTRY, Jan. 2016, 412(1-2):141 - 146, Refereed

Embryonic Hematopoietic Progenitor Cells Reside in Muscle before Bone Marrow Hematopoiesis
Yuka Tanaka; Tomoko Inoue-Yokoo; Kasem Kulkeaw; Chiyo Yanagi-Mizuochi; Senji Shirasawa; Yoichi Nakanishi; Daisuke Sugiyama
PLOS ONE, Sep. 2015, 10(9):e0138621, Refereed

Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells
Byong Hoon Yoo; Anna Zagryazhskaya; Yongling Li; Ananda Koomson; Iman Aftab Khan; Takehiko Sasazuki; Senji Shirasawa; Kirill V Rosen
AUTOPHAGY, Aug. 2015, 11(8):1230 - 1246, Refereed

Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells
Yuri Iwaihara; Shuhei Ishikura; Keiko Doi; Toshiyuki Tsunoda; Takahiro Fujimoto; Tadashi Okamura; Senji Shirasawa
ANTICANCER RESEARCH, Aug. 2015, 35(8):4419 - 4423, Refereed

Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules
Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Yuri Iwaihara; Hiromasa Hidesima; Hao Luo; Yumiko Hirose; Senji Shirasawa
ANTICANCER RESEARCH, Aug. 2015, 35(8):4453 - 4459, Refereed

Apoptosis-inducing Factor, Mitochondrion-associated 2, Regulates Klf1 in a Mouse Erythroleukemia Cell Line
Naoko Kojima; Yuka Tanaka; Kasem Kulkeaw; Yoichi Nakanishi; Senji Shirasawa; Daisuke Sugiyama
ANTICANCER RESEARCH, Aug. 2015, 35(8):4493 - 4499, Refereed

Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT
Naoya Tochio; Takashi Umehara; Kazuhiko Nakabayashi; Misao Yoneyama; Kengo Tsuda; Mikako Shirouzu; Seizo Koshiba; Satoru Watanabe; Takanori Kigawa; Takehiko Sasazuki; Senji Shirasawa; Shigeyuki Yokoyama
Journal of Structural and Functional Genomics, 15 Jun. 2015, 16(2):55 - 65, Refereed

Zfat-Deficient CD4(+)CD8(+) Double-Positive Thymocytes Are Susceptible to Apoptosis With Deregulated Activation of p38 and JNK
Shuhei Ishikura; Masahiro Ogawa; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Yoko Tanaka; Toshiyuki Tsunoda; Hiromasa Hideshima; Tadashi Okamura; Senji Shirasawa
JOURNAL OF CELLULAR BIOCHEMISTRY, Jan. 2015, 116(1):149 - 157, Refereed

Regulation of F-18-FDG Accumulation in Colorectal Cancer Cells with Mutated KRAS
Masayoshi Iwamoto; Kenji Kawada; Yuji Nakamoto; Yoshiro Itatani; Susumu Inamoto; Kosuke Toda; Hiroyuki Kimura; Takehiko Sasazuki; Senji Shirasawa; Hiroaki Okuyama; Masahiro Inoue; Suguru Hasegawa; Kaori Togashi; Yoshiharu Sakai
JOURNAL OF NUCLEAR MEDICINE, Dec. 2014, 55(12):2038 - 2044, Refereed

Competition between human cells by entosis
Qiang Sun; Tianzhi Luo; Yixin Ren; Oliver Florey; Senji Shirasawa; Takehiko Sasazuki; Douglas N. Robinson; Michael Overholtzer
CELL RESEARCH, Nov. 2014, 24(11):1299 - 1310, Refereed

The Roles of ZFAT in Thymocyte Differentiation and Homeostasis of Peripheral Naive T-Cells
Keiko Doi; Shuhei Ishikura; Senji Shirasawa
ANTICANCER RESEARCH, Aug. 2014, 34(8):4489 - 4495, Refereed

Resveratrol Induces Luminal Apoptosis of Human Colorectal Cancer HCT116 Cells in Three-dimensional Culture
Toshiyuki Tsunoda; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yuri Iwaihara; Senji Shirasawa
ANTICANCER RESEARCH, Aug. 2014, 34(8):4551 - 4555, Refereed

Dok2 Likely Down-regulates Klf1 in Mouse Erythroleukemia Cells
Yuka Tanaka; Kasem Kulkeaw; Tomoko Inoue; Keai Sinn Tan; Yoichi Nakanishi; Senji Shirasawa; Daisuke Sugiyama
ANTICANCER RESEARCH, Aug. 2014, 34(8):4561 - 4567, Refereed

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer
Sandra Van Schaeybroeck; Murugan Kalimutho; Philip D. Dunne; Robbie Carson; Wendy Allen; Puthen V. Jithesh; Keara L. Redmond; Takehiko Sasazuki; Senji Shirasawa; Jaine Blayney; Paolo Michieli; Cathy Fenning; Heinz-Josef Lenz; Mark Lawler; Daniel B. Longley; Patrick G. Johnston
CELL REPORTS, Jun. 2014, 7(6):1940 - 1955, Refereed

KRAS mutation confers resistance to antibody-dependent cellular cytotoxicity of cetuximab against human colorectal cancer cells
Yusuke Nakadate; Yasuo Kodera; Yuka Kitamura; Senji Shirasawa; Taro Tachibana; Tomohide Tamura; Fumiaki Koizumi
INTERNATIONAL JOURNAL OF CANCER, May 2014, 134(9):2146 - 2155, Refereed

Adrenomedullin is a therapeutic target in colorectal cancer
Liangjing Wang; Manish Gala; Masayoshi Yamamoto; Maria S. Pino; Hirotoshi Kikuchi; Daniel S. Shue; Senji Shirasawa; Thomas R. Austin; Maureen P. Lynch; Bo R. Rueda; Lawrence R. Zukerberg; Daniel C. Chung
INTERNATIONAL JOURNAL OF CANCER, May 2014, 134(9):2041 - 2050, Refereed

p120RasGAP Is a Mediator of Rho Pathway Activation and Tumorigenicity in the DLD1 Colorectal Cancer Cell Line
Shawna L. Organ; Josephine Hai; Nikolina Radulovich; Christopher B. Marshall; Lisa Leung; Takehiko Sasazuki; Senji Shirasawa; Chang-Qi Zhu; Roya Navab; Mitsuhiko Ikura; Ming-Sound Tsao
PLOS ONE, Jan. 2014, 9(1):e86103, Refereed

Zfat-Deficiency Results in a Loss of CD3ζ Phosphorylation with Dysregulation of ERK and Egr Activities Leading to Impaired Positive Selection
Masahiro Ogawa; Tadashi Okamura; Shuhei Ishikura; Keiko Doi; Hiroshi Matsuzaki; Yoko Tanaka; Takeharu Ota; Kunihiro Hayakawa; Harumi Suzuki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
PLoS ONE, 03 Oct. 2013, 8(10):e76254, Refereed

Roles of ZFAT in Haematopoiesis, Angiogenesis and Cancer Development
Toshiyuki Tsunoda; Senji Shirasawa
ANTICANCER RESEARCH, Jul. 2013, 33(7):2833 - 2837, Refereed

Molecular Hierarchy of Heparin-Binding EGF-like Growth Factor-Regulated Angiogenesis in Triple-Negative Breast Cancer
Fusanori Yotsumoto; Eriko Tokunaga; Eiji Oki; Yoshihiko Maehara; Hiromi Yamada; Kyoko Nakajima; Sung Ouk Nam; Kohei Miyata; Midori Koyanagi; Keiko Doi; Senji Shirasawa; Masahide Kuroki; Shingo Miyamoto
MOLECULAR CANCER RESEARCH, May 2013, 11(5):506 - 517, Refereed

MDR1 C3435T Polymorphism and Interaction with Environmental Factors in Risk of Parkinson's Disease: A Case-control Study in Japan
Chikako Kiyohara; Yoshihiro Miyake; Midori Koyanagi; Takahiro Fujimoto; Senji Shirasawa; Keiko Tanaka; Wakaba Fukushima; Satoshi Sasaki; Yoshio Tsuboi; Tatsuo Yamada; Tomoko Oeda; Hiroyuki Shimada; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yishio Hirota; Masaki Nagai
DRUG METABOLISM AND PHARMACOKINETICS, Apr. 2013, 28(2):138 - 143, Refereed

Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux
Hiroshi Matsuzaki; Takahiro Fujimoto; Masatoshi Tanaka; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2013, 433(3):322 - 326, Refereed

Tespa1 protein is phosphorylated in response to store-operated calcium entry
Takahiro Fujimoto; Hiroshi Matsuzaki; Masatoshi Tanaka; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2013, 434(1):162 - 165, Refereed

Identification of Mutant K-Ras-dependent Phenotypes Using a Panel of Isogenic Cell Lines
Steffan Vartanian; Carolyn Bentley; Matthew J. Brauer; Li Li; Senji Shirasawa; Takehiko Sasazuki; Jung-Sik Kim; Pete Haverty; Eric Stawiski; Zora Modrusan; Todd Waldman; David Stokoe
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2013, 288(4):2403 - 2413, Refereed

Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney
Takahiro Fujimoto; Senji Shirasawa
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Dec. 2012, 30(6):1287 - 1293, Refereed

High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells
Tomohiro Kozako; Akiyoshi Aikawa; Teruhisa Shoji; Takahiro Fujimoto; Makoto Yoshimitsu; Senji Shirasawa; Hiroaki Tanaka; Shin-ichiro Honda; Hiroshi Shimeno; Naomichi Arima; Shinji Soeda
INTERNATIONAL JOURNAL OF CANCER, Nov. 2012, 131(9):2044 - 2055, Refereed

Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA
Pat Gulhati; Yekaterina Y. Zaytseva; Joseph D. Valentino; Payton D. Stevens; Ji Tae Kim; Takehiko Sasazuki; Senji Shirasawa; Eun Y. Lee; Heidi L. Weiss; Jianli Dong; Tianyan Gao; B. Mark Evers
CARCINOGENESIS, Sep. 2012, 33(9):1782 - 1790, Refereed

Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation
Georgia Ikonomou; Vassiliki Kostourou; Senji Shirasawa; Takehiko Sasazuki; Martina Samiotaki; George Panayotou
JOURNAL OF PROTEOMICS, Sep. 2012, 75(17):5356 - 5369, Refereed

Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells
Hiu-Fung Yuen; Olga Abramczyk; Grant Montgomery; Ka-Kui Chan; Yu-Han Huang; Takehiko Sasazuki; Senji Shirasawa; Srivastava Gopesh; Kwok-Wah Chan; Dean Fennell; Pasi Janne; Mohamed El-Tanani; James T. Murray
BIOSCIENCE REPORTS, Aug. 2012, 32(4):413 - 422, Refereed

ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response
Keiko Doi; Takahiro Fujimoto; Tadashi Okamura; Masahiro Ogawa; Yoko Tanaka; Yasumasa Mototani; Motohito Goto; Takeharu Ota; Hiroshi Matsuzaki; Masahide Kuroki; Toshiyuki Tsunoda; Takehiko Sasazuki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2012, 425(1):107 - 112, Refereed

Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model
Toshiyuki Tsunoda; Takeharu Ota; Takahiro Fujimoto; Keiko Doi; Yoko Tanaka; Yasuhiro Yoshida; Masahiro Ogawa; Hiroshi Matsuzaki; Masato Hamabashiri; Darren R. Tyson; Masahide Kuroki; Shingo Miyamoto; Senji Shirasawa
MOLECULAR CANCER, Jul. 2012, 11(1):46, Refereed

KRAS Up-regulates the Expression of miR-181a, miR-200c and miR-210 in a Three-dimensional-specific Manner in DLD-1 Colorectal Cancer Cells
Takeharu Ota; Keiko Doi; Takahiro Fujimoto; Yoko Tanaka; Masahiro Ogawa; Hiroshi Matsuzaki; Masahide Kuroki; Shingo Miyamoto; Senji Shirasawa; Toshiyuki Tsunoda
ANTICANCER RESEARCH, Jun. 2012, 32(6):2271 - 2275, Refereed

ALPK2 is Crucial for Luminal Apoptosis and DNA Repair-related Gene Expression in a Three-dimensional Colonic-crypt Model
Yasuhiro Yoshida; Toshiyuki Tsunoda; Keiko Doi; Takahiro Fujimoto; Yoko Tanaka; Takeharu Ota; Masahiro Ogawa; Hiroshi Matsuzaki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
ANTICANCER RESEARCH, Jun. 2012, 32(6):2301 - 2308, Refereed

Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling
Ning Liu; Masaki Matsumoto; Kyoko Kitagawa; Yojiro Kotake; Sayuri Suzuki; Senji Shirasawa; Keiichi I. Nakayama; Makoto Nakanishi; Hiroyuki Niida; Masatoshi Kitagawa
EMBO JOURNAL, May 2012, 31(10):2365 - 2377, Refereed

Important Role of Epiregulin in Inflammatory Responses during Corneal Epithelial Wound Healing
Yuan Zhang; Takeshi Kobayashi; Yasuhito Hayashi; Ryuji Yoshioka; Atsushi Shiraishi; Senji Shirasawa; Shigeki Higashiyama; Yuichi Ohashi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Apr. 2012, 53(4):2414 - 2423, Refereed

Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes
Hiroshi Matsuzaki; Takahiro Fujimoto; Takeharu Ota; Masahiro Ogawa; Toshiyuki Tsunoda; Keiko Doi; Masato Hamabashiri; Masatoshi Tanaka; Senji Shirasawa
FEBS OPEN BIO, 2012, 2:255 - 259, Refereed

Oncogenic ras-induced Down-regulation of Pro-apoptotic Protease Caspase-2 Is Required for Malignant Transformation of Intestinal Epithelial Cells
Byong Hoon Yoo; Yanfei Wang; Mete Erdogan; Takehiko Sasazuki; Senji Shirasawa; Laurent Corcos; Kanaga Sabapathy; Kirill V. Rosen
JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2011, 286(45):38894 - 38903, Refereed

Identification of independent risk loci for Graves' disease within the MHC in the Japanese population
Kazuhiko Nakabayashi; Atsushi Tajima; Ken Yamamoto; Atsushi Takahashi; Kenichiro Hata; Yasuo Takashima; Midori Koyanagi; Hirofumi Nakaoka; Takashi Akamizu; Naofumi Ishikawa; Sumihisa Kubota; Shiro Maeda; Tatsuhiko Tsunoda; Michiaki Kubo; Naoyuki Kamatani; Yusuke Nakamura; Takehiko Sasazuki; Senji Shirasawa
JOURNAL OF HUMAN GENETICS, Nov. 2011, 56(11):772 - 778, Refereed

APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population
Chikako Kiyohara; Yoshihiro Miyake; Midori Koyanagi; Takahiro Fujimoto; Senji Shirasawa; Keiko Tanaka; Wakaba Fukushima; Satoshi Sasaki; Yoshio Tsuboi; Tatsuo Yamada; Tomoko Oeda; Takami Miki; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yoshio Hirota; Masaki Nagai
JOURNAL OF NEURAL TRANSMISSION, Sep. 2011, 118(9):1335 - 1344, Refereed

BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
Eleni Makrodouli; Eftychia Oikonomou; Michal Koc; Ladislav Andera; Takehiko Sasazuki; Senji Shirasawa; Alexander Pintzas
MOLECULAR CANCER, Sep. 2011, 10:118, Refereed

KRAS-induced Actin-interacting Protein: A Potent Target for Obesity, Diabetes and Cancer
Takahiro Fujimoto; Senji Shirasawa
ANTICANCER RESEARCH, Jul. 2011, 31(7):2413 - 2417, Refereed

Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population
Chikako Kiyohara; Yoshihiro Miyake; Midori Koyanagi; Takahiro Fujimoto; Senji Shirasawa; Keiko Tanaka; Wakaba Fukushima; Satoshi Sasaki; Yoshio Tsuboi; Tatsuo Yamada; Tomoko Oeda; Hiroyuki Shimada; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yoshio Hirota; Masaki Nagai
BMC NEUROLOGY, Jul. 2011, 11(1):89, Refereed

Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells
Toshiyuki Tsunoda; Yasuo Takashima; Yasuhiro Yoshida; Keiko Doi; Yoko Tanaka; Takahiro Fujimoto; Takashi Machida; Takeharu Ota; Midori Koyanagi; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
ANTICANCER RESEARCH, Jul. 2011, 31(7):2453 - 2459, Refereed

KRAS-mediated Up-regulation of RRM2 Expression Is Essential for the Proliferation of Colorectal Cancer Cell Lines
Yasuhiro Yoshida; Toshiyuki Tsunoda; Keiko Doi; Yoko Tanaka; Takahiro Fujimoto; Takashi Machida; Takeharu Ota; Midori Koyanagi; Yasuo Takashima; Takehiko Sasazuki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
ANTICANCER RESEARCH, Jul. 2011, 31(7):2535 - 2539, Refereed

KRAS-induced actin-interacting protein regulates inositol 1,4,5-trisphosphate-receptor-mediated calcium release
Takahiro Fujimoto; Takashi Machida; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Masahide Kuroki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2011, 408(2):214 - 217, Refereed

The Solute Carrier Family 15A4 Regulates TLR9 and NOD1 Functions in the Innate Immune System and Promotes Colitis in Mice
Shigemi Sasawatari; Tadashi Okamura; Eiji Kasumi; Kaori Tanaka-Furuyama; Rieko Yanobu-Takanashi; Senji Shirasawa; Norihiro Kato; Noriko Toyama-Sorimachi
GASTROENTEROLOGY, May 2011, 140(5):1513 - 1525, Refereed

Determination of the critical region of KRAS-induced actin-interacting protein for the interaction with inositol 1,4,5-trisphosphate receptor
Takahiro Fujimoto; Takashi Machida; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Masahide Kuroki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2011, 408(2):282 - 286, Refereed

KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells
Takahiro Fujimoto; Takashi Machida; Yoko Tanaka; Toshiyuki Tsunoda; Keiko Doi; Takeharu Ota; Tadashi Okamura; Masahide Kuroki; Senji Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2011, 407(2):438 - 443, Refereed

ZFAT IS A CRITICAL MOLECULE FOR CELL SURVIVAL IN MOUSE EMBRYONIC FIBROBLASTS
Keiko Doi; Takahiro Fujimoto; Midori Koyanagi; Toshiyuki Tsunoda; Yoko Tanaka; Yasuhiro Yoshida; Yasuo Takashima; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
CELLULAR & MOLECULAR BIOLOGY LETTERS, Mar. 2011, 16(1):89 - 100, Refereed

Oncogenic Kras Promotes Chemotherapy-Induced Growth Factor Shedding via ADAM17
Sandra Van Schaeybroeck; Joan N. Kyula; Audrey Fenton; Catherine S. Fenning; Takehiko Sasazuki; Senji Shirasawa; Daniel B. Longley; Patrick G. Johnston
CANCER RESEARCH, Feb. 2011, 71(3):1071 - 1080, Refereed

Case-Control Study of Eczema Associated with IL13 Genetic Polymorphisms in Japanese Children
Yoshihiro Miyake; Chikako Kiyohara; Midori Koyanagi; Takahiro Fujimoto; Senji Shirasawa; Keiko Tanaka; Satoshi Sasaki; Yoshio Hirota
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2011, 154(4):328 - 335, Refereed

Pancreatic Hypertrophy in Ki-ras-Induced Actin-Interacting Protein Gene Knockout Mice
Kyoko Miyasaka; Takahiro Fujimoto; Takako Kawanami; Soichi Takiguchi; Atsuo Jimi; Akihiro Funakoshi; Senji Shirasawa
PANCREAS, Jan. 2011, 40(1):79 - 83, Refereed

ZFAT is essential for endothelial cell assembly and the branch point formation of capillary-like structures in an angiogenesis model
Yasuhiro Yoshida; Toshiyuki Tsunoda; Yasuo Takashima; Takahiro Fujimoto; Keiko Doi; Takehiko Sasazuki; Masahide Kuroki; Akinori Iwasaki; Senji Shirasawa
CELLULAR & MOLECULAR BIOLOGY LETTERS, Dec. 2010, 15(4):541 - 550, Refereed

LRRIC2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson's disease: A case-control study in Japan
Yoshihiro Miyake; Yoshio Tsuboi; Midori Koyanagi; Takahiro Fujimoto; Senji Shirasawa; Chikako Kiyohara; Keiko Tanaka; Wakaba Fukushima; Satoshi Sasaki; Tatsuo Yamada; Tomoko Oeda; Takami Miki; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yoshio Hirota; Masaki Nagai
JOURNAL OF THE NEUROLOGICAL SCIENCES, Oct. 2010, 297(1-2):15 - 18, Refereed

GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population
C. Kiyohara; Y. Miyake; M. Koyanagi; T. Fujimoto; S. Shirasawa; K. Tanaka; W. Fukushima; S. Sasaki; Y. Tsuboi; T. Yamada; T. Oeda; T. Miki; N. Kawamura; N. Sakae; H. Fukuyama; Y. Hirota; M. Nagai
PARKINSONISM & RELATED DISORDERS, Aug. 2010, 16(7):447 - 452

Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands
Toshiyuki Tsunoda; Yasuo Takashima; Yoko Tanaka; Takahiro Fujimoto; Keiko Doi; Yumiko Hirose; Midori Koyanagi; Yasuhiro Yoshida; Tadashi Okamura; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2010, 107(32):14199 - 14204, Refereed

Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus
Federica Di Nicolantonio; Sabrina Arena; Josep Tabernero; Stefano Grosso; Francesca Molinari; Teresa Macarulla; Mariangela Russo; Carlotta Cancelliere; Davide Zecchin; Luca Mazzucchelli; Takehiko Sasazuki; Senji Shirasawa; Massimo Geuna; Milo Frattini; Jose Baselga; Margherita Gallicchio; Stefano Biffo; Alberto Bardelli
JOURNAL OF CLINICAL INVESTIGATION, Aug. 2010, 120(8):2858 - 2866, Refereed

4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors
Qing-Bai She; Ensar Halilovic; Qing Ye; Wei Zhen; Senji Shirasawa; Takehiko Sasazuki; David B. Solit; Neal Rosen
CANCER CELL, Jul. 2010, 18(1):39 - 51, Refereed

Three-dimensionally Specific Inhibition of DNA Repair-Related Genes by Activated KRAS in Colon Crypt Model
Toshiyuki Tsunoda; Yasuo Takashima; Takahiro Fujimoto; Midori Koyanagi; Yasuhiro Yoshida; Keiko Doi; Yoko Tanaka; Tanaka; Masahide Kuroki; Takehiko Sasazuki; Senji Shirasawa
NEOPLASIA, May 2010, 12(5):397 - U5, Refereed

Osteoblast-specific Factor 2 Expression in Prostate Cancer-associated Stroma: Identification Through Microarray Technology
Bungo Furusato; Toshiyuki Tsunoda; Syed Shaheduzzaman; Martin E. Nau; Maryanne Vahey; Gyorgy Petrovics; David G. McLeod; Seiji Naito; Senji Shirasawa; Shiv Srivastava; Isabell A. Sesterhenn
UROLOGY, Apr. 2010, 75(4):768 - 772, Refereed

Recent advances in the association studies of autoimmune thyroid disease and the functional characterization of AITD-related transcription factor ZFAT.
Nakabayashi K; Shirasawa S
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2010, 33(2):66 - 72, Refereed

Oncogenic KRAS and BRAF Differentially Regulate Hypoxia-inducible Factor-1 alpha and-2 alpha in Colon Cancer
Hirotoshi Kikuchi; Maria S. Pino; Min Zeng; Senji Shirasawa; Daniel C. Chung
CANCER RESEARCH, Nov. 2009, 69(21):8499 - 8506, Refereed

The Increased Expression of Periostin During Early Stages of Prostate Cancer and Advanced Stages of Cancer Stroma
Toshiyuki Tsunoda; Bunjo Furusato; Yasuo Takashima; Suma Ravulapalli; Albert Dobi; Shiv Srivastava; David G. McLeod; Isabell A. Sesterhenn; David K. Ornstein; Senji Shirasawa
PROSTATE, Sep. 2009, 69(13):1398 - 1403, Refereed

Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-RaSG13D
Alessandro Palmioli; Elena Sacco; Cristina Airoldi; Federica Di Nicolantonio; Annalisa D'Urzo; Senji Shirasawa; Takehiko Sasazuki; Alessandro Di Domizio; Luca De Gioia; Enzo Martegani; Alberto Bardelli; Francesco Peri; Marco Vanoni
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2009, 386(4):593 - 597, Refereed

Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers
Kazuhiko Nakabayashi; Gen Komaki; Atsushi Tajima; Tetsuya Ando; Mayuko Ishikawa; Junko Nomoto; Kenichiro Hata; Akira Oka; Hidetoshi Inoko; Takehiko Sasazuki; Senji Shirasawa
JOURNAL OF HUMAN GENETICS, Sep. 2009, 54(9):531 - 537, Refereed

TGF-beta Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a beta-Catenin-independent Pathway
Patty Trobridge; Sue Knoblaugh; M. Kay Washington; Nina M. Munoz; Karen D. Tsuchiya; Andres Rojas; Xiaoling Song; Cornelia M. Ulrich; Takehiko Sasazuki; Senji Shirasawa; William M. Grady
GASTROENTEROLOGY, May 2009, 136(5):1680 - 1688, Refereed

[Genome-wide association studies: recent advances and future directions].
Nakabayashi K; Tajima A; Shirasawa S
Nihon rinsho. Japanese journal of clinical medicine, Mar. 2009, 67(3):469 - 476, Refereed

ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells
Takahiro Fujimoto; Keiko Doi; Midori Koyanagi; Toshiyuki Tsunoda; Yasuo Takashima; Yasuhiro Yoshida; Takehiko Sasazuki; Senji Shirasawa
FEBS LETTERS, Feb. 2009, 583(3):568 - 572, Refereed

Altered Energy Homeostasis and Resistance to Diet-Induced Obesity in KRAP-Deficient Mice
Takahiro Fujimoto; Kyoko Miyasaka; Midori Koyanagi; Toshiyuki Tsunoda; Iwai Baba; Keiko Doi; Minoru Ohta; Norihiro Kato; Takehiko Sasazuki; Senji Shirasawa
PLOS ONE, Jan. 2009, 4(1):e4240, Refereed

Oncogenic ras-induced downregulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells.
Yoo BH; Woo X; Li Y; Haniff M; Sasazuki T; Shirasawa S; Eskelinen EL; Rosen KV
J. Biol. Chem., 2009, 285(8):5438 - 5449, Refereed

Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2
Nicole Fehrenbacher; Lone Bastholm; Thomas Kirkegaard-Sorensen; Bo Rafn; Trine Bottzauw; Christina Nielsen; Ekkehard Weber; Senji Shirasawa; Tuula Kallunki; Marja Jaattela
CANCER RESEARCH, Aug. 2008, 68(16):6623 - 6633, Refereed

Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: The role of p53 and p21
Jose M. Escandell; Pawan Kaler; M. Carmen Recio; Takehiko Sasazuki; Senji Shirasawa; Leonard Augenlicht; Jose-Luis Rios; Lidija Klampfer
BIOCHEMICAL PHARMACOLOGY, Jul. 2008, 76(2):198 - 207, Refereed

Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts
S. Shahrzad; S. Shirasawa; T. Sasazuki; J. W. Rak; B. L. Coomber
ONCOGENE, Jun. 2008, 27(26):3729 - 3738, Refereed

TATA box-binding protein-associated factor 12 is important for RAS-induced transformation properties of colorectal cancer cells
Angeliki Voulgari; Stella Voskou; Laszlo Tora; Irwin Davidson; Takehiko Sasazuki; Senji Shirasawa; Alexander Pintzas
MOLECULAR CANCER RESEARCH, Jun. 2008, 6(6):1071 - 1083, Refereed

ZFAT expression in B and T lymphocytes and identification of ZFAT-regulated genes
Midori Koyanagi; Kazuhiko Nakabayashi; Takahiro Fujimoto; Ning Gu; Iwai Baba; Yasuo Takashima; Keiko Doi; Haruhito Harada; Norihiro Kato; Takehiko Sasazuki; Senji Shirasawa
GENOMICS, May 2008, 91(5):451 - 457, Refereed

Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma
Steven Yea; Goutham Narla; Xiao Zhao; Rakhi Garg; Sigal Tal-Kremer; Eldad Hod; Augusto Villanueva; Johnny Loke; Mirko Tarocchi; Kunihara Akita; Senji Shirasawa; Takehiko Sasazuki; John A. Martignetti; Josep M. Llovet; Scott L. Friedman
GASTROENTEROLOGY, May 2008, 134(5):1521 - 1531, Refereed

Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q
F. Takeuchi; Y. Ochiai; M. Serizawa; K. Yanai; N. Kuzuya; H. Kajio; S. Honjo; N. Takeda; Y. Kaburagi; K. Yasuda; S. Shirasawa; T. Sasazuki; N. Kato
JOURNAL OF HUMAN GENETICS, Apr. 2008, 53(4):314 - 324, Refereed

HDAC2 deficiency sensitizes colon cancer cells to TNF alpha-induced apoptosis through inhibition of NF-kappa B activity
Pawan Kaler; Takehiko Sasazuki; Senji Shirasawa; Leonard Augenlicht; Lidija Klampfer
EXPERIMENTAL CELL RESEARCH, Apr. 2008, 314(7):1507 - 1518, Refereed

Functional analysis of ZFAT through specific siRNA against ZFAT in Ba/F3 cell line.
Midori Koyanagi; Keiko Doi; Takahiro Fujimoto; Toshiyuki Tsunoda; Yasuo Takashima; Senji Shirasawa
Medical Bulletin of Fukuoka University, 2008, 35(4):187 - 191, Refereed

Analysis of KRAP expression and localization, and genes regulated by KRAP in a human colon cancer cell line
Takahiro Fujimoto; Midori Koyanagi; Iwai Baba; Kazuhiko Nakabayashi; Norihiro Kato; Takehiko Sasazuki; Senji Shirasawa
JOURNAL OF HUMAN GENETICS, Dec. 2007, 52(12):978 - 984, Refereed

Histone deacetylase inhibitors induce cell death selectively in cells that Harbor activated kRasV12: The role of signal transducers and activators of transcription 1 and p21
Lidija Klampfer; Jie Huang; Senji Shirasawa; Takehiko Sasazuki; Leonard Augenlicht
CANCER RESEARCH, Sep. 2007, 67(18):8477 - 8485, Refereed

Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo
Mathieu Derouet; Xue Wu; Linda May; Byong Hoon Yoo; Takehiko Sasazuki; Senji Shirasawa; Janusz Rak; Kirill V. Rosen
NEOPLASIA, Jul. 2007, 9(7):536 - 545, Refereed

Search of type 2 diabetes susceptibility gene on chromosome 20q
F. Takeuchi; K. Yanai; H. Inomata; N. Kuzuya; H. Kajio; S. Honjo; N. Takeda; Y. Kaburagi; K. Yasuda; S. Shirasawa; T. Sasazuki; N. Kato
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2007, 357(4):1100 - 1106, Refereed

Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells
Faiy H. Psahoulia; Sophy Moumtzi; Michael L. Roberts; Takehiko Sasazuki; Senji Shirasawa; Alexander Pintzas
CARCINOGENESIS, May 2007, 28(5):1021 - 1031, Refereed

Transcriptional control of the human high mobility group A1 gene: Basal and oncogenic Ras-regulated expression
Isabelle Cleynen; Christel Huysmans; Takehiko Sasazuki; Senji Shirasawa; Wim Van de Ven; Kristel Peeters
CANCER RESEARCH, May 2007, 67(10):4620 - 4629, Refereed

STAT1-independent inhibition of cyclooxygenase-2 expression by IFN gamma; a common pathway of IFN gamma-mediated gene repression but not gene activation
L. Klampfer; J. Huang; P. Kaler; T. Sasazuki; S. Shirasawa; L. Augenlicht
ONCOGENE, Mar. 2007, 26(14):2071 - 2081, Refereed

ゲノムワイド解析による摂食障害遺伝子の探索と今後の課題(パネルディスカッション : 肥満・摂食障害の分子機構,2006年,第47回日本心身医学会総会(東京))
Nakabayashi Kazuhiko; Shirasawa Senji
Japanese Journal of Psychosomatic Medicine, 2007, 47(4):259 - 264

Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells
Aparna V. Sarthy; Susan E. Morgan-Lappe; Dorothy Zakula; Lawrence Vernetti; Mark Schurdak; Jeremy C. L. Packer; Mark G. Anderson; Senji Shirasawa; Takehiko Sasazuki; Stephen W. Fesik
MOLECULAR CANCER THERAPEUTICS, Jan. 2007, 6(1):269 - 276, Refereed

Detachment-induced upregulation of XIAP and cIAP2 delays anoikis of intestinal epithelial cells
Z. Liu; H. Li; X. Wu; B. H. Yoo; S. R. Yan; A. W. Stadnyk; T. Sasazuki; S. Shirasawa; E. C. LaCasse; R. G. Korneluk; K. V. Rosen
ONCOGENE, Dec. 2006, 25(59):7680 - 7690, Refereed

Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells
F Teraishi; W Guo; LD Zhang; FQ Dong; JJ Davis; T Sasazuki; S Shirasawa; JS Liu; BL Fang
CANCER RESEARCH, Jun. 2006, 66(12):6072 - 6079

Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm
ZP Liu; HB Li; M Derouet; A Berezkin; T Sasazuki; S Shirasawa; K Rosen
JOURNAL OF BIOLOGICAL CHEMISTRY, May 2006, 281(21):14738 - 14747

KRAS(D13) promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand
N Smakman; DJM van den Wollenberg; SG Elias; T Sasazuki; S Shirasawa; RC Hoeben; IHMB Rinkes; O Kranenblug
CANCER RESEARCH, May 2006, 66(10):5403 - 5408

Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells
S Sugiyama; K Nakabayashi; Baba, I; T Sasazuki; S Shirasawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2005, 337(1):271 - 274

Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
LP Cheng; OA Samad; Y Xu; R Mizuguchi; P Luo; S Shirasawa; M Goulding; QF Ma
NATURE NEUROSCIENCE, Nov. 2005, 8(11):1510 - 1515

Ischemia-induced K-ras mutations in human colorectal cancer cells: Role of microenvironmental regulation of MSH2 expression
S Shahrzad; L Quayle; C Stone; C Plumb; S Shirasawa; JW Rak; BL Coomber
CANCER RESEARCH, Sep. 2005, 65(18):8134 - 8141

Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway
KG Drosopoulos; ML Roberts; L Cermak; T Sasazuki; S Shirasawa; L Andera; A Pintzas
JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2005, 280(24):22856 - 22867

Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis
L Klampfer; LA Swaby; H Huang; T Sasazuki; S Shirasawa; L Augenlicht
ONCOGENE, Jun. 2005, 24(24):3932 - 3941

A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities
Y Kochi; R Yamada; A Suzuki; JB Harley; S Shirasawa; T Sawada; SC Bae; S Tokuhiro; XT Chang; A Sekine; A Takahashi; T Tsunoda; Y Ohnishi; KM Kaufman; CSP Kang; CW Kang; S Otsubo; W Yumura; A Mimori; T Koike; Y Nakamura; T Sasazuki; K Yamamoto
NATURE GENETICS, May 2005, 37(5):478 - 485

Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease
H Hiratani; DW Bowden; S Ikegami; S Shirasawa; A Shimizu; Y Iwatani; T Akamizu
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, May 2005, 90(5):2898 - 2903

Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells
RW Caron; A Yacoub; C Mitchell; XY Zhu; Y Hong; T Sasazuki; S Shirasawa; MP Hagan; S Grant; P Dent
CELL CYCLE, Mar. 2005, 4(3):456 - 464, Refereed

Mapping of the critical region of mitogene-inducible gene-6 for NK-κB activation.
R Mabuchi; T Sasazuki; S Shirasawa
ONCOLOGY REPORTS, Mar. 2005, 13(3):473 - 476

H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent
RW Caron; A Yacoub; XY Zhu; C Mitchell; SI Han; T Sasazuki; S Shirasawa; MP Hagan; S Grant; P Dent
MOLECULAR CANCER THERAPEUTICS, Feb. 2005, 4(2):243 - 255

Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells
CB Pollock; S Shirasawa; T Sasazuki; W Kolch; AS Dhillon
CANCER RESEARCH, Feb. 2005, 65(4):1244 - 1250

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival
RW Caron; A Yacoub; M Li; XY Zhu; C Mitchell; Y Hong; W Hawkins; T Sasazuki; S Shirasawa; AP Kozikowski; PA Dennis; MP Hagan; S Grant; P Dent
MOLECULAR CANCER THERAPEUTICS, Feb. 2005, 4(2):257 - 270

Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis
JL Yu; L May; Lhotak, V; S Shahrzad; S Shirasawa; JI Weitz; BL Coomber; N Mackman; JW Rak
BLOOD, Feb. 2005, 105(4):1734 - 1741

Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese
H Nawata; S Shirasawa; N Nakashima; E Araki; J Hashiguchi; S Miyake; T Yamauchi; K Hamaguchi; H Yoshimatsu; H Takeda; H Fukushima; T Sasahara; K Yamaguchi; N Sonoda; T Sonoda; M Matsumoto; Y Tanaka; H Sugimoto; H Tsubouchi; T Inoguchi; T Yanase; N Wake; K Narazaki; T Eto; F Umeda; M Nakazaki; J Ono; T Asano; Y Ito; S Akazawa; Hazegawa, I; N Takasu; M Shinohara; T Nishikawa; S Nagafuchi; T Okeda; K Eguchi; M Iwase; M Ishikawa; M Aoki; N Keicho; N Kato; K Yasuda; K Yamamoto; T Sasazuki
JOURNAL OF HUMAN GENETICS, Nov. 2004, 49(11):629 - 634, Refereed

Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity
S Shichijo; N Keicho; HT Long; T Quy; NC Phi; LD Ha; VV Ban; S Itoyama; CJ Hu; N Komatsu; T Kirikae; F Kirikae; S Shirasawa; M Kaji; T Fukuda; M Sata; T Kuratsuji; K Itoh; T Sasazuki
TISSUE ANTIGENS, Nov. 2004, 64(5):600 - 607, Refereed

In vitro visualization of respiratory neuron activity in the newborn mouse ventral medulla
H Onimaru; A Arata; S Arata; S Shirasawa; ML Cleary
DEVELOPMENTAL BRAIN RESEARCH, Nov. 2004, 153(2):275 - 279, Refereed

SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease
S Shirasawa; H Harada; K Furugaki; T Akamizu; N Ishikawa; K Ito; K Ito; H Tamai; K Kuma; S Kubota; H Hiratani; T Tsuchiya; Baba, I; M Ishikawa; M Tanaka; K Sakai; M Aoki; K Yamamoto; T Sasazuki
HUMAN MOLECULAR GENETICS, Oct. 2004, 13(19):2221 - 2231, Refereed

Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage
S Shirasawa; S Sugiyama; Baba, I; J Inokuchi; S Sekine; K Ogino; Y Kawamura; T Dohi; M Fujimoto; T Sasazuki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2004, 101(38):13921 - 13926, Refereed

B lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse
N Asano; M Fujimoto; N Yazawa; S Shirasawa; M Hasegawa; H Okochi; K Tamaki; TF Tedder; S Sato
AMERICAN JOURNAL OF PATHOLOGY, Aug. 2004, 165(2):641 - 650

Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression
L Klampfer; J Huang; T Sasazuki; S Shirasawa; L Augenlicht
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2004, 279(35):36680 - 36688, Refereed

Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
LP Cheng; A Arata; R Mizuguchi; Y Qian; A Karunaratne; PA Gray; S Arata; S Shirasawa; M Bouchard; P Luo; CL Chen; M Busslinger; M Goulding; H Onimaru; QF Ma
NATURE NEUROSCIENCE, May 2004, 7(5):510 - 517, Refereed

P38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor
XM Qi; J Tang; R Pramanik; RM Schultz; S Shirasawa; T Sasazuki; JH Han; G Chen
JOURNAL OF BIOLOGICAL CHEMISTRY, May 2004, 279(21):22138 - 22144, Refereed

Association of the T-cell regulatory gene CTLA4 with Graves’ disease and autoimmune thyroid disease in the Japanese
K Furugaki; S Shirasawa; N Ishikawa; K Ito; K Ito; S Kubota; K Kuma; H Tamai; T Akamizu; H Hiratani; M Tanaka; T Sasazuki
JOURNAL OF HUMAN GENETICS, Mar. 2004, 49(3):166 - 168, Refereed

Polycomb group suppressor of zeste 12 links heterochromatin protein 1 alpha and enhancer of zeste 2
K Yamamoto; M Sonoda; J Inokuchi; S Shirasawa; T Sasazuki
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2004, 279(1):401 - 406, Refereed

Deregulated expression of KRAP, a novel gene encoding actin-interacting protein, in human colon cancer cells
J Inokuchi; M Komiya; Baba, I; S Naito; T Sasazuki; S Shirasawa
JOURNAL OF HUMAN GENETICS, Jan. 2004, 49(1):46 - 52

Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/- mice
MA Parisi; AE Baldessari; MHK Iida; CM Clarke; B Doggett; S Shirasawa; RP Kapur
GASTROENTEROLOGY, Nov. 2003, 125(5):1428 - 1440

Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression
L Klampfer; J Huang; G Corner; J Mariadason; D Arango; T Sasazuki; S Shirasawa; L Augenlicht
JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2003, 278(47):46278 - 46287, Refereed

Inhibition of interferon gamma signaling by the short chain fatty acid butyrate
L Klampfer; J Huang; T Sasazuki; S Shirasawa; L Augenlicht
MOLECULAR CANCER RESEARCH, Sep. 2003, 1(11):855 - 862, Refereed

Met receptor overexpression and oncogenic Ki-ras mutation cooperate to enhance tumorigenicity of colon cancer cells in vivo
IS Long; K Han; M Li; S Shirasawa; T Sasazuki; M Johnston; MS Tsao
MOLECULAR CANCER RESEARCH, Mar. 2003, 1(5):393 - 401

A novel mechanism of nuclear factor ・B activation through the binding between inhibitor of nuclear factor-・Bτ and the processed NH2-terminal region of Mig-6
T Tsunoda; J Inokuchi; Baba, I; K Okumura; S Naito; T Sasazuki; S Shirasawa
CANCER RESEARCH, Oct. 2002, 62(20):5668 - 5671

Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1
Y Qian; S Shirasawa; CL Chen; LP Cheng; QF Ma
GENES & DEVELOPMENT, May 2002, 16(10):1220 - 1233

Congenital central hypoventilation syndrome: a novel mutation of the RET gene in an isolated case
M Kanai; C Numakura; A Sasaki; E Shirahata; K Akaba; M Hashimoto; H Hasegawa; S Shirasawa; K Hayasaka
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, Apr. 2002, 196(4):241 - 246

The impact of oncogenes on tumor maintenance
Shirasawa S; Sasazuki T
Oncogene-Directed Therapies (Rak JW. Ed., Human Press Inc., Totowa), 2002, :229 - 243

Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3
Y Qian; B Fritzsch; S Shirasawa; CL Chen; YJ Choi; QF Ma
GENES & DEVELOPMENT, Oct. 2001, 15(19):2533 - 2545

Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q133 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese
K Sakai; S Shirasawa; N Ishikawa; K Ito; H Tamai; K Kuma; T Akamizu; M Tanimura; K Furugaki; K Yamamoto; T Sasazuki
HUMAN MOLECULAR GENETICS, Jun. 2001, 10(13):1379 - 1386

cDNA array analyses of K-Ras-induced gene transcription
GG Habets; M Knepper; J Sumortin; YJ Choi; T Sasazuki; S Shirasawa; G Bollag
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT F, RAS FAMILY I, 2001, 332:245 - 260

Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells
Baba, I; S Shirasawa; R Iwamoto; K Okumura; T Tsunoda; M Nishioka; K Fukuyama; K Yamamoto; E Mekada; T Sasazuki
CANCER RESEARCH, Dec. 2000, 60(24):6886 - 6889

Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19(ARF)
S Ries; C Biederer; D Woods; O Shifman; S Shirasawa; T Sasazuki; M McMahon; M Oren; F McCormick
CELL, Oct. 2000, 103(2):321 - 330

Rnx deficiency results in congenital central hypoventilation
S Shirasawa; A Arata; H Onimaru; KA Roth; GA Brown; S Horning; S Arata; K Okumura; T Sasazuki; SJ Korsmeyer
NATURE GENETICS, Mar. 2000, 24(3):287 - 290

Targeted disruption of the K-Ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis
H Allgayer; H Wang; S Shirasawa; T Sasazuki; D Boyd
BRITISH JOURNAL OF CANCER, Aug. 1999, 80(12):1884 - 1891

Activated Ki-ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells
K Okumura; S Shirasawa; M Nishioka; T Sasazuki
CANCER RESEARCH, May 1999, 59(10):2445 - 2450

Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
F Okada; JW Rak; B St Croix; B Lieubeau; M Kaya; L Roncari; S Shirasawa; T Sasazuki; RS Kerbel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 1998, 95(7):3609 - 3614

MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line
CJ Savoie; N Kamikawaji; T Sudo; M Furuse; S Shirasawa; T Tana; T Sasazuki
CANCER LETTERS, Jan. 1998, 123(2):193 - 197

Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells
M Ohmori; S Shirasawa; M Furuse; K Okumura; T Sasazuki
CANCER RESEARCH, Nov. 1997, 57(21):4714 - 4717

Suppression of serum-induced c-jun expression by activated Ki-ras in human colon cancer cells
M Furuse; S Shirasawa; K Okumura; M Ohmori; T Sasazuki
JAPANESE JOURNAL OF HUMAN GENETICS, Sep. 1997, 42(3):409 - 416

Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon
S Shirasawa; AMR Yunker; KA Roth; GA Brown; S Horning; SJ Korsmeyer
NATURE MEDICINE, Jun. 1997, 3(6):646 - 650

MUTANT RAS ONCOGENES UP-REGULATE VEGF/VPF EXPRESSION - IMPLICATIONS FOR INDUCTION AND INHIBITION OF TUMOR ANGIOGENESIS
J RAK; Y MITSUHASHI; L BAYKO; J FILMUS; S SHIRASAWA; T SASAZUKI; RS KERBEL
CANCER RESEARCH, Oct. 1995, 55(20):4575 - 4580

ALTERED GROWTH OF HUMAN COLON CANCER CELL-LINES DISRUPTED AT ACTIVATED KI-RAS
S SHIRASAWA; M FURUSE; N YOKOYAMA; T SASAZUKI
SCIENCE, Apr. 1993, 260(5104):85 - 88

P53 GENE-MUTATIONS IN COLORECTAL TUMORS FROM PATIENTS WITH FAMILIAL POLYPOSIS-COLI
S SHIRASAWA; K URABE; Y YANAGAWA; K TOSHITANI; T IWAMA; T SASAZUKI
CANCER RESEARCH, Jun. 1991, 51(11):2874 - 2878

Znフィンガータンパク質Zfatのセントロメアへの局在
石倉 周平; 中林 一彦; 白澤 専二
日本生化学会大会プログラム・講演要旨集, Sep. 2018, 91回:[1P - 241]

新規レスベラトロール誘導体は大腸癌細胞三次元増殖を抑制する
澤田 悠賀; 松川 泰治; 土井 聡; 角田 俊之; 岡本 春奈; 苗村 円佳; 田原 圭一郎; 有川 和沙; 松岡 耕平; 原田 正樹; 大貫 宏一郎; 白澤 専二; 神武 洋二郎
生命科学系学会合同年次大会, Dec. 2017, 2017年度:[3P - 1297]

消化器癌に対する遺伝子療法の抗腫瘍抗体による標的化
Shirasawa S; Nabeshima K; Kuroki M; Tachibana K; Yamashita Y; Sakisaka S; Iwamoto T; Saku K; Hiromatsu K; Saito T; Miyamoto S; Tamura K; Hara S
MEXT-Supported Program for the Strategic Research Foundation at Private Universities: Central Research Institute for Advanced Molecular Medicine, Fukuoka University - Overview Reports, 2013, 1(1):107 - 181

癌・生活習慣病・免疫関連疾患の病因・病態解明と分子標的療法開発／消化器癌に対する遺伝子療法の抗腫瘍抗体による標的化
Shirasawa S; Nabeshima K; Kuroki M; Tachibana K; Yamashita Y; Sakisaka S; Iwamoto T; Saku K; Hiromatsu K; Saito T; Miyamoto S; Tamura K; Hara S
Annual Reports of Central Research Center for Advanced Molecular Medicine, Fukuoka University, 2011, 1(1):53 - 108

Translational regulation of hypoxia-inducible factor-1 alpha and 2 alpha by mutant oncogenes in colon cancer
Hirotoshi Kikuchi; Maria S. Pino; Min Zeng; Senji Shirasawa; Hiroyuki Konno; Daniel C. Chung
CANCER RESEARCH, Apr. 2010, 70

バイオ治療法研究会

日本癌学会

新規抗腫瘍薬を利用した腫瘍免疫微小環境におけるKRAS制御機構の解明と制御法開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2021 - 31 Mar. 2024

大腸癌細胞塊における生体内類似変異KRAS制御シグナルの解明及び阻害剤の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2018 - 31 Mar. 2021

変異KRASが制御する微小環境と発癌分子機構の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2015 - 31 Mar. 2018

肺癌における変異ＫＲＡＳ制御末梢分泌型ｍｉｃｒｏＲＮＡの解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2015

免疫疾患関連転写因子ＺＦＡＴのコンディショナルノックアウトマウスを用いた機能解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2015

変異ＫＲＡＳを起点とした大腸癌フィールドエフェクトの解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
Fukuoka University
01 Apr. 2012 - 31 Mar. 2015

自己免疫疾患関連転写制御因子の生命機能における基盤的研究
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
Fukuoka University
2009 - 2012

糖尿病の遺伝素因に基づいた創薬に関する試験研究
Jul. 2006 - Mar. 2010

ゲノムネットワークプロジェクト
Jun. 2006 - May 2009

ゲノムネットワークプロジェクト
Jun. 2006 - May 2009

自己免疫性甲状腺疾患を中心とした自己免疫疾患関連遺伝子の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas
Research Institute, International Medical Center of Japan
2005 - 2009

オーダーメイド医療実現化プロジェクト
Apr. 2006 - Mar. 2008

自己免疫疾患関連遺伝子ZFAT及びZFATに制御される免疫疾患関連遺伝子群の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
2005 - 2008

タンパク3000プロジェクト
Apr. 2006 - Mar. 2007

自己免疫性甲状腺疾患の疾患感受性遺伝子の同定
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas
2002 - 2004

自己免疫性甲状腺疾患(橋本病)の疾患感受性遺伝子の同定とその機能解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A)
2000 - 2003

変異Ki-Rasにより発現制御される癌関連遺伝子の同定・機能解析
日本学術振興会, 科学研究費助成事業, 特定領域研究(C)
国立国際医療センター(研究所)
2001 - 2001

胸腺におけるT細胞レパトワ決定機構の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)
KYUSHU UNIVERSITY
1999 - 2001

変異Ki-Rasにより発現制御される新規がん関連遺伝子の単離機能解析
日本学術振興会, 科学研究費助成事業, 特定領域研究(C)
九州大学
2000 - 2000

橋本病における疾患感受性遺伝子の同定
日本学術振興会, 科学研究費助成事業, 特定領域研究(C)
九州大学
2000 - 2000

CD4^+CD8^+胸腺細胞特異的単クローン抗体のリガンドの同定とその機能解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
KYUSHU UNIVERSITY
1999 - 2000

遺伝子標的法を用いた新規がん関連遺伝子の同定および機能解析
日本学術振興会, 科学研究費助成事業, 特定領域研究(A)
九州大学
1999 - 1999

自己免疫性甲状腺疾患の遺伝因子の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B).
KYOTO UNIVERSITY
1998 - 1999

アメリカ大陸を中心としたがん研究先進グループとの研究交流
日本学術振興会, 科学研究費助成事業, 特定領域研究(A)
東京大学
1997 - 1999

胸腺内T細胞分化におけるTCR・MHC/ペプチド複合体相互作用の生化学的解析
日本学術振興会, 科学研究費助成事業, 重点領域研究
九州大学
1997 - 1997

HLA結合ペプチドライブラリーを用いた癌特異的T細胞の誘導及び癌抗原群の解明
日本学術振興会, 科学研究費助成事業, 重点領域研究
九州大学
1997 - 1997

ヒト免疫モデルマウス(マウスMHC,CD4欠損ヒトCD4,HLA導入)の樹立-ヒト免疫応答の再現-
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C)
KYUSHU UNIVERSITY
1996 - 1997

HLAを利用したアレルギー反応の特異的抑制療法開発のための基礎研究
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A)
Kyushu University
1995 - 1997

HLA結合性ペプチドライブラリーを用いた癌特異的T細胞の誘導及び癌抗原群の同定
日本学術振興会, 科学研究費助成事業, 重点領域研究
九州大学
1996 - 1996

HLA多重遺伝子族による免疫応答および疾患感受性制御の分子機構の解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for international Scientific Research
KYUSHU UNIVERSITY
1993 - 1995

8,580,562, PCT/JP2008/66155, ZFAT遺伝子発現制御RNA
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特許第5294344号, 特願2010-527642, 白血病治療用医薬組成物
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PCT/JP2010/066864, イノシトール－１，４，５－トリスリン酸受容体結合タンパク質およびそれを含むトランスジェニック非ヒト哺乳動物
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特許第4296016号, 特願2003-084650, エピレグリン遺伝子欠損動物およびその利用方法
白澤専二, 笹月健彦

国際公開WO2007/010999, KRAP遺伝子変異による脂質代謝および糖代謝改変動物、改変方法および改変剤
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